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Found 123 with Last Name = 'o''donovan' and Initial = 'dh'
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50019492((+)2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020341(CLONIDINE HYDROCHLORIDE | Catapres | Clonidine HCl...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020363(CHEMBL3289551)
Affinity DataKi:  79nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020373(CHEMBL3289540)
Affinity DataKi:  141nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020343(CHEMBL3289532)
Affinity DataKi:  214nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020364(CHEMBL3289521)
Affinity DataKi:  263nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020353(CHEMBL3289522)
Affinity DataKi:  389nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020344(CHEMBL3289531)
Affinity DataKi:  513nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020370(CHEMBL3289537)
Affinity DataKi:  676nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020360(CHEMBL3289548)
Affinity DataKi:  692nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020355(CHEMBL3289543)
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020345(CHEMBL3289530)
Affinity DataKi:  1.07E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020369(CHEMBL3289536)
Affinity DataKi:  1.12E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020359(CHEMBL3289547)
Affinity DataKi:  1.32E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020342(CHEMBL3289533)
Affinity DataKi:  1.48E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020346(CHEMBL3289529)
Affinity DataKi:  1.51E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020362(CHEMBL3289550)
Affinity DataKi:  1.70E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020349(CHEMBL3289526)
Affinity DataKi:  1.74E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020348(CHEMBL3289527)
Affinity DataKi:  1.86E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020361(CHEMBL3289549)
Affinity DataKi:  2.19E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020352(CHEMBL3289523)
Affinity DataKi:  2.24E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020357(CHEMBL3289545)
Affinity DataKi:  2.34E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020358(CHEMBL3289546)
Affinity DataKi:  2.63E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020354(CHEMBL3289542)
Affinity DataKi:  3.31E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020367(CHEMBL3289535)
Affinity DataKi:  4.27E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020366(CHEMBL3289534)
Affinity DataKi:  4.37E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020365(CHEMBL3289520)
Affinity DataKi:  4.90E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020371(CHEMBL3289538)
Affinity DataKi:  8.32E+3nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020351(CHEMBL3289524)
Affinity DataKi:  1.17E+4nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020356(CHEMBL3289544)
Affinity DataKi:  1.23E+4nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020374(CHEMBL3289541)
Affinity DataKi:  1.41E+4nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020372(CHEMBL3289539)
Affinity DataKi:  1.51E+4nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020350(CHEMBL3289525)
Affinity DataKi:  1.86E+4nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50020347(CHEMBL3289528)
Affinity DataKi:  1.91E+4nMAssay Description:Displacement of [3H]RX821002 from alpha2-adrenergic receptor in prefrontal cortex of human brain after 30 mins by liquid scintillation spectrometric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM300953(N-(4-((6S,8R)-7-(2,2-difluoropropyl)-8-methyl-6,7,...)
Affinity DataIC50:  0.0398nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM300962(1-(3-fluoropropyl)-N-(3-methoxy-4-((6S,8R)-8-methy...)
Affinity DataIC50:  0.0631nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM300955(N-(4-((6S,8R)-7-(2,2-difluoroethyl)-8-methyl-6,7,8...)
Affinity DataIC50:  0.100nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM300969(BDBM300970 | N-(1-(3- fluoropropyl) azetidin-3-yl)...)
Affinity DataIC50:  0.126nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha expression in presence of cycloheximide by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM299117((6S,8R)-7-((l-fluorocyclopropyl)methyl)-6-(4-(2-(3...)
Affinity DataIC50:  0.126nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM299111(US10125135, Example 1)
Affinity DataIC50:  0.126nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548427(CHEMBL4780809)
Affinity DataIC50:  0.126nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM299115((6S,8R)-7-(2-fluoro-2-methylpropyl)-6-(4-(2-(3-(fl...)
Affinity DataIC50:  0.158nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548432(CHEMBL4785486)
Affinity DataIC50:  0.158nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM299139((6R,8R)-6-(4-(2- (3- (fluoromethyl) azetidin-1- yl...)
Affinity DataIC50:  0.158nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM300969(BDBM300970 | N-(1-(3- fluoropropyl) azetidin-3-yl)...)
Affinity DataIC50:  0.158nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ERalpha expression by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM300969(BDBM300970 | N-(1-(3- fluoropropyl) azetidin-3-yl)...)
Affinity DataIC50:  0.158nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM300994(2,2-difluoro-3- ((6S,8R)-6-(4- ((1-(3- fluoropropy...)
Affinity DataIC50:  0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM300998(N-(4-((6S,8R)- 7-(2-fluoro-2- methylpropyl)- 8-met...)
Affinity DataIC50:  0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM299144((6S,8R)-6-(2,6- difluoro-4-(2-(3- (fluoromethyl) a...)
Affinity DataIC50:  0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM300968(N-(1-(3- fluoropropyl) azetidin-3-yl)- N-methyl-6-...)
Affinity DataIC50:  0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells assessed as decrease in ER-alpha level incubated for 18 to 24 hrs by Alexa fluor 488/Hoechst sta...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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