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Found 117 with Last Name = 'paschke' and Initial = 'm'
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293905((S)-4-amino-5-(4-(4-(2,4-dichloro-3-((2,4-dimethyl...)
Affinity DataIC50:  0.0500nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Cavia porcellus)
Jerini

Curated by ChEMBL
LigandPNGBDBM50074986((E)-N-({[4-Chloro-2-cyano-3-(2-methyl-quinolin-8-y...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [3H]bradykinin from guinea pig B2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293902(1-{4-methyl-3-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  0.540nMAssay Description:Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293906((S)-4-carbamimidoyl-N-(4-(1-(2,4-dichloro-3-((2,4-...)
Affinity DataIC50:  0.670nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
3B Pharmaceuticals

US Patent
LigandPNGBDBM466499(US10799605, Example 4)
Affinity DataIC50:  0.870nMAssay Description:In order to determine the binding affinity of compounds comprising a radiolabel for NTR1, a radioligand binding assay was carried out. A radioligand ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293904(1-((4-methyl-3-((2-methyl-4-(4-methyl-1H-pyrazol-5...)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293903(1-((3-((4-(5-chlorothiazol-4-yl)-2-methylquinolin-...)
Affinity DataIC50:  1.30nMAssay Description:Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293899(1-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50067301((E)-3-(6-Acetylamino-pyridin-3-yl)-N-({[2,4-dichlo...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293901(CHEMBL559565 | cyclohexanecarboxylic acid{4-methyl...)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293890(CHEMBL550827 | N-{5-chloro-4-[2-methyl-4-(2-methyl...)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293891(3-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  2.80nMAssay Description:Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
3B Pharmaceuticals

US Patent
LigandPNGBDBM466500(US10799605, Example 5)
Affinity DataIC50:  2.90nMAssay Description:In order to determine the binding affinity of compounds comprising a radiolabel for NTR1, a radioligand binding assay was carried out. A radioligand ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeurotensin receptor type 1(Homo sapiens (Human))
3B Pharmaceuticals

US Patent
LigandPNGBDBM466502(US10799605, Example 13)
Affinity DataIC50:  3nMAssay Description:In order to determine the binding affinity of compounds comprising a radiolabel for NTR1, a radioligand binding assay was carried out. A radioligand ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeurotensin receptor type 1(Homo sapiens (Human))
3B Pharmaceuticals

US Patent
LigandPNGBDBM466505(US10799605, Example 19)
Affinity DataIC50:  3.40nMAssay Description:In order to determine the binding affinity of compounds comprising a radiolabel for NTR1, a radioligand binding assay was carried out. A radioligand ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293897(1-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  3.60nMAssay Description:Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293900(CHEMBL559506 | N-{4-methyl-3-[2-methyl-4-(2-methyl...)
Affinity DataIC50:  3.80nMAssay Description:Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293899(1-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
3B Pharmaceuticals

US Patent
LigandPNGBDBM466501(US10799605, Example 12)
Affinity DataIC50:  4.90nMAssay Description:In order to determine the binding affinity of compounds comprising a radiolabel for NTR1, a radioligand binding assay was carried out. A radioligand ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293897(1-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  5.10nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
3B Pharmaceuticals

US Patent
LigandPNGBDBM466504(US10799605, Example 18)
Affinity DataIC50:  5.30nMAssay Description:In order to determine the binding affinity of compounds comprising a radiolabel for NTR1, a radioligand binding assay was carried out. A radioligand ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293900(CHEMBL559506 | N-{4-methyl-3-[2-methyl-4-(2-methyl...)
Affinity DataIC50:  5.40nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293895(CHEMBL562296 | acetic acid 5-chloro-4-[2-methyl-4-...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293888(2-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  6.5nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293891(3-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  6.60nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293886(2-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  7.5nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
3B Pharmaceuticals

US Patent
LigandPNGBDBM466499(US10799605, Example 4)
Affinity DataIC50:  7.54nMAssay Description:Ca2+ ions are usually kept at nanomolar levels in the cytosol of cells, and act in a number of signal transduction pathways as second messengers. Man...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293890(CHEMBL550827 | N-{5-chloro-4-[2-methyl-4-(2-methyl...)
Affinity DataIC50:  7.80nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293892(CHEMBL552090 | dimethyl-carbamic acid 5-chloro-4-[...)
Affinity DataIC50:  8.30nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293904(1-((4-methyl-3-((2-methyl-4-(4-methyl-1H-pyrazol-5...)
Affinity DataIC50:  8.70nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293902(1-{4-methyl-3-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  8.80nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
3B Pharmaceuticals

US Patent
LigandPNGBDBM466504(US10799605, Example 18)
Affinity DataIC50:  8.95nMAssay Description:Ca2+ ions are usually kept at nanomolar levels in the cytosol of cells, and act in a number of signal transduction pathways as second messengers. Man...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293903(1-((3-((4-(5-chlorothiazol-4-yl)-2-methylquinolin-...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293901(CHEMBL559565 | cyclohexanecarboxylic acid{4-methyl...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293892(CHEMBL552090 | dimethyl-carbamic acid 5-chloro-4-[...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293894(CHEMBL552384 | N-{5-chloro-4-[2-methyl-4-(2-methyl...)
Affinity DataIC50:  12nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
3B Pharmaceuticals

US Patent
LigandPNGBDBM466505(US10799605, Example 19)
Affinity DataIC50:  12.6nMAssay Description:Ca2+ ions are usually kept at nanomolar levels in the cytosol of cells, and act in a number of signal transduction pathways as second messengers. Man...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293896(CHEMBL552296 | N-{5-chloro-4-[2-methyl-4-(2-methyl...)
Affinity DataIC50:  14nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
3B Pharmaceuticals

US Patent
LigandPNGBDBM466502(US10799605, Example 13)
Affinity DataIC50:  17.5nMAssay Description:Ca2+ ions are usually kept at nanomolar levels in the cytosol of cells, and act in a number of signal transduction pathways as second messengers. Man...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293885(8-((3-chloro-5-(1-methyl-1H-imidazol-2-ylthio)pyri...)
Affinity DataIC50:  18nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
3B Pharmaceuticals

US Patent
LigandPNGBDBM466500(US10799605, Example 5)
Affinity DataIC50:  20nMAssay Description:Ca2+ ions are usually kept at nanomolar levels in the cytosol of cells, and act in a number of signal transduction pathways as second messengers. Man...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293880(8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-(4...)
Affinity DataIC50:  20nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
3B Pharmaceuticals

US Patent
LigandPNGBDBM466501(US10799605, Example 12)
Affinity DataIC50:  21.4nMAssay Description:Ca2+ ions are usually kept at nanomolar levels in the cytosol of cells, and act in a number of signal transduction pathways as second messengers. Man...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293894(CHEMBL552384 | N-{5-chloro-4-[2-methyl-4-(2-methyl...)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293886(2-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293884(8-[3-chloro-5-(thiazol-2-ylsulfanyl)-pyridin-4-ylm...)
Affinity DataIC50:  29nMAssay Description:Antagonist activity at B2 receptor in human HF15 cells assessed as inhibition of bradykinin-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293866(8-(3,5-dichloro-pyridin-4-ylmethoxy)-2-methyl-4-py...)
Affinity DataIC50:  32nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293893(3-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  33nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293889(3-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  36nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Jerini

Curated by ChEMBL
LigandPNGBDBM50293887(2-{5-chloro-4-[2-methyl-4-(2-methyl-2H-pyrazol-3-y...)
Affinity DataIC50:  37nMAssay Description:Displacement of [3H]bradykinin from human recombinant B2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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