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Found 48 with Last Name = 'perros' and Initial = 'm'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50400788(CHEMBL2203612)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483552(Lersivirine | UK-453061)
Affinity DataKi:  117nMAssay Description:Mixed non-competitive inhibition of HIV1 reverse transcriptase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50189399((S)-N-(3-(4-(2-(4-fluorophenyl)acetamido)piperidin...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50400791(CHEMBL2203619)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50400795(CHEMBL2203615)
Affinity DataIC50:  2nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50189401(CHEMBL214818 | N-((S)-3-(3-(2-methyl-1H-benzo[d]im...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50189394((S)-N-(3-(4-(3-benzyl-1H-1,2,4-triazol-1-yl)piperi...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50400794(CHEMBL2203616)
Affinity DataIC50:  6nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50189400(CHEMBL213914 | N-[(1S)-3-[2'-(2-methyl-1H-1,3-benz...)
Affinity DataIC50:  6nMAssay Description:Inhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Pfizer

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of HIV1 reverse transcriptase activity by primer extension assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50400787(CHEMBL2203613)
Affinity DataIC50:  8nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50400788(CHEMBL2203612)
Affinity DataIC50:  9nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Pfizer

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  14nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50400792(CHEMBL2203618)
Affinity DataIC50:  17nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50189397((S)-N-(3-(4-(5-benzyl-1,2,4-oxadiazol-3-yl)piperid...)
Affinity DataIC50:  20nMAssay Description:Inhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50400796(CHEMBL2203614)
Affinity DataIC50:  20nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50400790(CHEMBL2203620)
Affinity DataIC50:  21.5nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Pfizer

LigandPNGBDBM27577(5-[(3-ethyl-5-fluoro-1H-indazol-4-yl)oxy]benzene-1...)
Affinity DataIC50:  25nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Pfizer

LigandPNGBDBM27577(5-[(3-ethyl-5-fluoro-1H-indazol-4-yl)oxy]benzene-1...)
Affinity DataIC50:  32nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50189395(CHEMBL413501 | N-((S)-3-(7-(2-methyl-1H-benzo[d]im...)
Affinity DataIC50:  39nMAssay Description:Inhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50400789(CHEMBL2203621)
Affinity DataIC50:  39.7nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Pfizer

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  40nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Pfizer

LigandPNGBDBM27579(AG 1549 | CPV | Capravirine | {5-[(3,5-dichlorophe...)
Affinity DataIC50:  47nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50189393((S)-N-(3-(4-(3,5-dimethyl-4H-1,2,4-triazol-4-yl)pi...)
Affinity DataIC50:  50nMAssay Description:Inhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Pfizer

LigandPNGBDBM27576(5-[(5-fluoro-3-methyl-1H-indazol-4-yl)oxy]benzene-...)
Affinity DataIC50:  50nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Pfizer

LigandPNGBDBM27579(AG 1549 | CPV | Capravirine | {5-[(3,5-dichlorophe...)
Affinity DataIC50:  61nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027,K691N]/[588-1147,K690N](Human immunodeficiency virus type 1)
Pfizer

LigandPNGBDBM27579(AG 1549 | CPV | Capravirine | {5-[(3,5-dichlorophe...)
Affinity DataIC50:  68nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50189396((S)-N-(3-(4-(5-methyl-1,2,4-oxadiazol-3-yl)piperid...)
Affinity DataIC50:  70nMAssay Description:Inhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Pfizer

LigandPNGBDBM27578(5-{[7-(hydroxymethyl)-3-methyl-1H-indazol-4-yl]oxy...)
Affinity DataIC50:  71nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Pfizer

LigandPNGBDBM27572(5-[(3-ethyl-1H-indazol-4-yl)oxy]benzene-1,3-dicarb...)
Affinity DataIC50:  112nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483552(Lersivirine | UK-453061)
Affinity DataIC50:  118nMAssay Description:Inhibition of HIV1 reverse transcriptase activity by primer extension assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
Pfizer

LigandPNGBDBM27576(5-[(5-fluoro-3-methyl-1H-indazol-4-yl)oxy]benzene-...)
Affinity DataIC50:  145nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027,K691N]/[588-1147,K690N](Human immunodeficiency virus type 1)
Pfizer

LigandPNGBDBM27577(5-[(3-ethyl-5-fluoro-1H-indazol-4-yl)oxy]benzene-1...)
Affinity DataIC50:  183nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483552(Lersivirine | UK-453061)
Affinity DataIC50:  215nMAssay Description:Inhibition of HIV1 HXB2 reverse transcriptase K103N mutant activity by primer extension assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50189398((S)-N-(3-(4-(3-benzyl-5-methyl-4H-1,2,4-triazol-4-...)
Affinity DataIC50:  250nMAssay Description:Inhibition of [125I]MIP-1beta binding to CCR5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Pfizer

LigandPNGBDBM27571(5-[(3-methyl-1H-indazol-4-yl)oxy]benzene-1,3-dicar...)
Affinity DataIC50:  332nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027,K691N]/[588-1147,K690N](Human immunodeficiency virus type 1)
Pfizer

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  364nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027,K691N]/[588-1147,K690N](Human immunodeficiency virus type 1)
Pfizer

LigandPNGBDBM27576(5-[(5-fluoro-3-methyl-1H-indazol-4-yl)oxy]benzene-...)
Affinity DataIC50:  384nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Pfizer

LigandPNGBDBM27575(5-[(5-chloro-3-methyl-1H-indazol-4-yl)oxy]benzene-...)
Affinity DataIC50:  399nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Pfizer

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  414nMAssay Description:Inhibition of HIV1 HXB2 reverse transcriptase K103N mutant activity by primer extension assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50400793(CHEMBL2203617)
Affinity DataIC50: >1.00E+3nMAssay Description:Displacement of [125I]MIP-1beta from CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027,K691N]/[588-1147,K690N](Human immunodeficiency virus type 1)
Pfizer

LigandPNGBDBM27578(5-{[7-(hydroxymethyl)-3-methyl-1H-indazol-4-yl]oxy...)
Affinity DataIC50:  1.27E+3nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Pfizer

LigandPNGBDBM27574(5-{[3-(methoxymethyl)-1H-indazol-4-yl]oxy}benzene-...)
Affinity DataIC50:  1.67E+3nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50302396(5-(3,5-diethyl-1H-pyrazol-4-yloxy)isophthalonitril...)
Affinity DataIC50:  9.80E+3nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Pfizer

LigandPNGBDBM27573(5-({3-[(methylamino)methyl]-1H-indazol-4-yl}oxy)be...)
Affinity DataIC50: >3.00E+4nMpH: 7.8 T: 2°CAssay Description:The inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme was measured using a primer extension assay. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50302397(3-(3,5-diethyl-1H-pyrazol-4-yloxy)-5-chlorobenzoni...)
Affinity DataIC50:  3.90E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50302398(3-(3,5-diethyl-1H-pyrazol-4-yloxy)-5-methylbenzoni...)
Affinity DataIC50:  1.00E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483552(Lersivirine | UK-453061)
Affinity DataKd:  624nMAssay Description:Binding affinity to recombinant HIV1 reverse transcriptase by isothermal calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed