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Found 1615 with Last Name = 'piwinski' and Initial = 'jj'
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332270((R)-3-((4-((6-methoxy-1-oxoisoindolin-2-yl)methyl)...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332292((R)-5-((4-(3-hydroxypyridin-2-yl)phenyl)ethynyl)-5...)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50264895(5-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)phenyl)-2...)
Affinity DataKi:  0.100nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in HEK293 cells assessed as reversal of N-alpha-methylhistamine-induced inhibition of fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM102669(CHEMBL1288726 | US8541572, 976)
Affinity DataKi:  0.100nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325003((R)-5-(4-(5-chloro-6-oxo-1,6-dihydropyridin-3-yl)p...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332265((R)-5-((2-fluorophenyl)ethynyl)-5-((6-methoxy-1-ox...)
Affinity DataKi:  0.130nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332262((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataKi:  0.140nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332289((R)-5-((4-((4-ethylpiperazin-1-yl)(hydroxyimino)me...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332288((R)-4-((4-((6-methoxy-1-oxoisoindolin-2-yl)methyl)...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332278((R)-5-((1H-indol-5-yl)ethynyl)-5-((6-methoxy-1-oxo...)
Affinity DataKi:  0.170nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332290((R)-5-((6-((4-ethylpiperazin-1-yl)(hydroxyimino)me...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332279((R)-5-((1H-indol-6-yl)ethynyl)-5-((6-methoxy-1-oxo...)
Affinity DataKi:  0.190nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50343977((2R,3R)-2,3-dihydroxy-4-(isoindolin-2-yl)-4-oxo-N-...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116083(3,5-Dichloro-N-[3-(3,4-dichloro-phenyl)-5-(3-dimet...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding to Tachykinin receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175828(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116745(CHEMBL78284 | N-{(R)-5-[4-(3-Carbamoylmethyl-2-oxo...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50325002((R)-5-((6-fluoro-1-oxoisoindolin-2-yl)methyl)-5-(4...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of TACE assessed as inhibition of pro-TNFalpha peptide cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332264((R)-5-((3-fluorophenyl)ethynyl)-5-((6-methoxy-1-ox...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175843(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332291((R)-5-((4-((hydroxyimino)(4-methylpiperazin-1-yl)m...)
Affinity DataKi:  0.220nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332263((R)-5-((4-fluorophenyl)ethynyl)-5-((6-methoxy-1-ox...)
Affinity DataKi:  0.260nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332285((R)-5-((4-((4-ethylpiperazin-1-yl)methyl)phenyl)et...)
Affinity DataKi:  0.290nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116082(3,5-Dichloro-N-(3-(3,4-dichloro-phenyl)-5-{3-[2-(2...)
Affinity DataKi:  0.300nMAssay Description:In vitro binding to Tachykinin receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116076(CHEMBL441252 | N-[5-(3-Carbamoylmethyl-2-oxo-[1,4'...)
Affinity DataKi:  0.300nMAssay Description:In vitro binding to Tachykinin receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116091(3,5-Dichloro-N-[3-(3,4-dichloro-phenyl)-5-(3-dimet...)
Affinity DataKi:  0.300nMAssay Description:In vitro binding to Tachykinin receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116722(CHEMBL263243 | N-{(R)-5-{4-[3-((R)-1-Carbamoyl-2-h...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against recombinant human tachykinin receptor 3 in CHO cells using [125I]-[MePhe]-NKB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116717(3,5-Dichloro-N-[(R)-3-(3,4-dichloro-phenyl)-2-[(Z)...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against recombinant human tachykinin receptor 3 in CHO cells using [125I]-[MePhe]-NKB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116736(CHEMBL74956 | N-{(R)-5-{4-[3-(1-Carbamoyl-1-methyl...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against recombinant human tachykinin receptor 3 in CHO cells using [125I]-[MePhe]-NKB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116745(CHEMBL78284 | N-{(R)-5-[4-(3-Carbamoylmethyl-2-oxo...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116074(CHEMBL66635 | N-[5-(3-Carbamoylmethyl-2-oxo-[1,4']...)
Affinity DataKi:  0.300nMAssay Description:In vitro binding to Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM85739(CHEMBL178372 | JTE-907 | N-(1,3-Benzodioxole-5-ylm...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity for cannabinoid receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116074(CHEMBL66635 | N-[5-(3-Carbamoylmethyl-2-oxo-[1,4']...)
Affinity DataKi:  0.400nMAssay Description:In vitro binding to Tachykinin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116745(CHEMBL78284 | N-{(R)-5-[4-(3-Carbamoylmethyl-2-oxo...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against recombinant human tachykinin receptor 3 in CHO cells using [125I]-[MePhe]-NKB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116080(3,5-Dichloro-N-{3-(3,4-dichloro-phenyl)-2-methoxyi...)
Affinity DataKi:  0.400nMAssay Description:In vitro binding to Tachykinin receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177371(2-((R)-4-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)e...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177376(4-((3,5-bis(trifluoromethyl)benzyloxy)methyl)-4-(4...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-Sar-Met Substance P from recombinant human NK1 receptor in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22542(4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175843(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175833(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50313839((R)-5-((6-chloro-1-oxoisoindolin-2-yl)methyl)-5-(4...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of TACE by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342973((2R,3R)-N-((R)-1-(4-(1H-pyrazol-1-yl)phenyl)ethyl)...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50342953((2R,3R)-2,3-dihydroxy-4-{(2R)-2-[2-(methylamino)-5...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50110653(3,5-Dichloro-N-[(R)-3-(3,4-dichloro-phenyl)-2-[(Z)...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116717(3,5-Dichloro-N-[(R)-3-(3,4-dichloro-phenyl)-2-[(Z)...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116732(3,5-Dichloro-N-{(R)-3-(3,4-dichloro-phenyl)-5-{4-[...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against recombinant human tachykinin receptor 3 in CHO cells using [125I]-[MePhe]-NKB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116733(3,5-Dichloro-N-{(R)-3-(3,4-dichloro-phenyl)-2-[(Z)...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against recombinant human tachykinin receptor 1 in CHO cells using [3H]-Sar SP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116736(CHEMBL74956 | N-{(R)-5-{4-[3-(1-Carbamoyl-1-methyl...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50116078(3,5-Dichloro-N-[3-(3,4-dichloro-phenyl)-2-methoxyi...)
Affinity DataKi:  0.400nMAssay Description:In vitro binding to Tachykinin receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50332266((R)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)-5-(...)
Affinity DataKi:  0.410nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM102890(CHEMBL1288211 | US8541572, 2283)
Affinity DataKi:  0.420nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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