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Found 129 with Last Name = 'pollock' and Initial = 'rm'
LigandPNGBDBM92649(EPZ004777)
Affinity DataKi:  0.300nM Kd:  0.100nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM297395(US10112968, Compound D16)
Affinity DataKi:  0.300nM Kd:  0.0100nM Kon:  0.000300M-1s-1 Koff:  3.00E+6s-1Assay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM92648(EPZ004450)
Affinity DataKi:  4nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM92647(EPZ003696)
Affinity DataKi:  13nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM297394(US10112968, Compound C118)
Affinity DataKi:  13nM Kd:  1.70nM Kon:  0.0200M-1s-1 Koff:  1.20E+7s-1Assay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM92642(SAH)
Affinity DataKi:  320nM Kd:  71nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM297392(US10112968, Compound SAH)
Affinity DataKi:  320nM Kd:  71nM Kon:  0.100M-1s-1 Koff:  1.40E+6s-1Assay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM297393(US10112968, Compound C94)
Affinity DataKi:  845nM Kd:  167nM Kon:  0.200M-1s-1 Koff:  1.20E+6s-1Assay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM92646(EPZ003647)
Affinity DataKi:  845nM Kd:  167nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM92644(EPZ002446)
Affinity DataKi:  1.20E+4nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM92645(EPZ003144)
Affinity DataKi:  2.00E+4nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM92643(EPZ000004)
Affinity DataKi:  3.80E+4nMAssay Description:Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific [1-416](Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM244794(US9446064, A75)
Affinity DataIC50:  0.590nMAssay Description:An in vitro biological assay that can be used includes the steps of (1) mixing a histone substrate (e.g., an isolated histone sample for a histone or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific [1-416](Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM244792(US9446064, A5)
Affinity DataIC50:  0.590nMAssay Description:An in vitro biological assay that can be used includes the steps of (1) mixing a histone substrate (e.g., an isolated histone sample for a histone or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM297391((2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3...)
Affinity DataIC50:  0.590nMAssay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific [1-416](Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM244795(US9446064, A86)
Affinity DataIC50:  0.620nMAssay Description:An in vitro biological assay that can be used includes the steps of (1) mixing a histone substrate (e.g., an isolated histone sample for a histone or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific [1-416](Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM244791(US9446064, A3)
Affinity DataIC50:  0.730nMAssay Description:An in vitro biological assay that can be used includes the steps of (1) mixing a histone substrate (e.g., an isolated histone sample for a histone or...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM297390((2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1s,3...)
Affinity DataIC50:  0.730nMAssay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific [1-416](Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM50075098(CHEMBL3414626 | US10143704, Compound A2 | US944606...)
Affinity DataIC50:  0.740nMAssay Description:An in vitro biological assay that can be used includes the steps of (1) mixing a histone substrate (e.g., an isolated histone sample for a histone or...More data for this Ligand-Target Pair
LigandPNGBDBM50075098(CHEMBL3414626 | US10143704, Compound A2 | US944606...)
Affinity DataIC50:  0.740nMAssay Description:Test compounds were serially diluted 3 fold in DMSO for 10 points and 1 μl was plated in a 384 well microtiter plate. Positive control (100% inh...More data for this Ligand-Target Pair
LigandPNGBDBM297389((2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3...)
Affinity DataIC50:  0.740nMAssay Description:Unless otherwise indicated, assays of DOT1L enzymatic activity were performed under balanced conditions (all substrates present at concentrations equ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific [1-416](Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM244796(US9446064, A87)
Affinity DataIC50:  0.800nMAssay Description:An in vitro biological assay that can be used includes the steps of (1) mixing a histone substrate (e.g., an isolated histone sample for a histone or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific [1-416](Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM244797(US9446064, A91)
Affinity DataIC50:  2.18nMAssay Description:An in vitro biological assay that can be used includes the steps of (1) mixing a histone substrate (e.g., an isolated histone sample for a histone or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific [1-416](Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM244793(US9446064, A69)
Affinity DataIC50:  2.51nMAssay Description:An in vitro biological assay that can be used includes the steps of (1) mixing a histone substrate (e.g., an isolated histone sample for a histone or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific [1-416](Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM244798(US9446064, A93)
Affinity DataIC50:  2.92nMAssay Description:An in vitro biological assay that can be used includes the steps of (1) mixing a histone substrate (e.g., an isolated histone sample for a histone or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM178085(US10307413, Compound 188 | US10391089, Compound 18...)
Affinity DataIC50:  3nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM178085(US10307413, Compound 188 | US10391089, Compound 18...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM177922(US10307413, Compound 337 | US10391089, Compound 16...)
Affinity DataIC50:  9nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149902(CHEMBL3771372)
Affinity DataIC50:  10nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149895(CHEMBL3770000)
Affinity DataIC50:  10nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149889(CHEMBL3769571)
Affinity DataIC50:  10nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM336999(US9745291, Compound 269 | US9745291, Compound 45 |...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM176872(US10307413, Compound 44 | US10391089, Compound 44 ...)
Affinity DataIC50:  13nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM176841(US10307413, Compound 20 | US10391089, Compound 20 ...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM176815(US10307413, Compound 1 | US10391089, Compound 1 | ...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM336999(US9745291, Compound 269 | US9745291, Compound 45 |...)
Affinity DataIC50:  16nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM176872(US10307413, Compound 44 | US10391089, Compound 44 ...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM190198(EPZ008279 | US9175331, 27)
Affinity DataIC50:  20nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM177922(US10307413, Compound 337 | US10391089, Compound 16...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM336960(US9745291, Compound 6 | US9765068, Compound 6)
Affinity DataIC50:  23nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149884(CHEMBL3770973)
Affinity DataIC50:  30nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149882(CHEMBL3771083)
Affinity DataIC50:  30nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149901(CHEMBL3770820)
Affinity DataIC50:  30nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149896(CHEMBL3771013)
Affinity DataIC50:  30nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM176841(US10307413, Compound 20 | US10391089, Compound 20 ...)
Affinity DataIC50:  32nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM343824(1-(3,4-Dihydroisoquinolin-2(1H)-yl)-3-((4-(1-methy...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human full length FLAG-tagged PRMT5/human His6-tagged MEP50 expressed in baculovirus-infected Sf9 cells assessed as reduction in tritiu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM336960(US9745291, Compound 6 | US9765068, Compound 6)
Affinity DataIC50:  36nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM176815(US10307413, Compound 1 | US10391089, Compound 1 | ...)
Affinity DataIC50:  37nMAssay Description:Inhibition of PRMT5 in human Z138 cells assessed as reduction in symmetrical dimethylation of arginine containing substrate using SmD3 as substrate i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149706(CHEMBL3769652)
Affinity DataIC50:  50nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

Curated by ChEMBL
LigandPNGBDBM50149705(CHEMBL3771343)
Affinity DataIC50:  50nMAssay Description:Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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