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Found 136 with Last Name = 'rocher' and Initial = 'jp'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492703(CHEMBL2408158)
Affinity DataIC50:  53nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492718(CHEMBL2408008)
Affinity DataIC50:  60nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50051408(CHEMBL3337527 | US11071729, Compound 2)
Affinity DataIC50:  68nMAssay Description:Displacement of [3H]19 from human mGlu2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492724(CHEMBL2408176)
Affinity DataIC50:  77nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492705(CHEMBL2408007)
Affinity DataIC50:  90nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492726(CHEMBL2408161)
Affinity DataIC50:  108nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492704(CHEMBL2408152)
Affinity DataIC50:  262nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492721(CHEMBL2408183)
Affinity DataIC50:  316nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492733(CHEMBL2408193)
Affinity DataIC50:  364nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492720(CHEMBL2408157)
Affinity DataIC50:  390nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492731(CHEMBL2408170)
Affinity DataIC50:  669nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492716(CHEMBL2408168)
Affinity DataIC50:  675nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492707(CHEMBL2407102)
Affinity DataIC50:  769nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492714(CHEMBL2408172)
Affinity DataIC50:  1.24E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492717(CHEMBL2408165)
Affinity DataIC50:  1.29E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492719(CHEMBL2408173)
Affinity DataIC50:  1.52E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492708(CHEMBL2408184)
Affinity DataIC50:  1.55E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492729(CHEMBL2408180)
Affinity DataIC50:  1.57E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492723(CHEMBL2408192)
Affinity DataIC50:  1.61E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492702(CHEMBL2408159)
Affinity DataIC50:  1.81E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492713(CHEMBL2408174)
Affinity DataIC50:  1.90E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492710(CHEMBL2408181)
Affinity DataIC50:  2.50E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492732(CHEMBL2408160)
Affinity DataIC50:  2.62E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492722(CHEMBL2408175)
Affinity DataIC50:  2.65E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492715(CHEMBL2408169)
Affinity DataIC50:  3.00E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492725(CHEMBL2408167)
Affinity DataIC50:  3.08E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492712(CHEMBL2408178)
Affinity DataIC50:  3.99E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492730(CHEMBL2408177)
Affinity DataIC50:  4.23E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492711(CHEMBL2408179)
Affinity DataIC50:  4.50E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492735(CHEMBL2408156)
Affinity DataIC50:  4.74E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492700(CHEMBL2408163)
Affinity DataIC50:  5.38E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492728(CHEMBL2408186)
Affinity DataIC50:  5.90E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492701(CHEMBL2408162)
Affinity DataIC50:  7.18E+3nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492727(CHEMBL2408197)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492734(CHEMBL2408171)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492706(CHEMBL2408198)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Addex Therapeutics

Curated by ChEMBL
LigandPNGBDBM50492709(CHEMBL2408182)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of rat mGluR5 receptor expressed in HEK293 cells assessed as intracellular calcium flux after 170 seconds by FLIPR ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50383364(CHEMBL2029819)
Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50383365(CHEMBL2029820)
Affinity DataEC50:  64nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50383366(CHEMBL2029821)
Affinity DataEC50:  316nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50383367(CHEMBL2029822)
Affinity DataEC50:  390nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50383368(CHEMBL2029823)
Affinity DataEC50:  372nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50383369(CHEMBL2029797)
Affinity DataEC50:  42nMAssay Description:Positive allosteric modulation of human mGlu2 receptor expressed in CHO cells assessed as glutamate-induced [35S]GTPgammaS binding after 30 mins by l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50417815(CHEMBL1669391)
Affinity DataEC50:  398nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50417816(CHEMBL1669392)
Affinity DataEC50:  501nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50417817(CHEMBL1669393)
Affinity DataEC50:  631nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50417818(CHEMBL1669394)
Affinity DataEC50:  316nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50417819(CHEMBL1669395)
Affinity DataEC50:  316nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50417820(CHEMBL1669396)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50417821(CHEMBL1669397)
Affinity DataEC50:  158nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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