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Found 1549 with Last Name = 'salter-cid' and Initial = 'lm'
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM23165(CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-a...)
Affinity DataIC50:  0.00800nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by radioligand competitive binding analy...More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50169441(CHEMBL3806205)
Affinity DataIC50:  0.0100nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by radioligand competitive binding analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM258470(US9522888, 697)
Affinity DataIC50:  0.0140nMAssay Description:Displacement of [33P]-SIP from human recombinant S1P1 expressed in CHO cell membranes measured after 45 mins by radioligand competitive binding analy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239718(CHEMBL4064666 | US10214537, Example 639)
Affinity DataIC50: <0.100nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Mus musculus)
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM21958(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at gardiquimod stimulated TRL7 in mouse whole blood assessed as inhibition of IL-6 production by ELISA analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM197654(US9216972, 7)
Affinity DataIC50:  0.380nMAssay Description:Binding affinity to human S1P1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267827(CHEMBL4076794)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267796(CHEMBL4098840)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267826(CHEMBL4096145)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267804(CHEMBL4070136)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50232433(CHEMBL4068514 | US10214537, Example 619)
Affinity DataIC50:  0.5nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267806(CHEMBL4071255)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267852(CHEMBL4073562)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267852(CHEMBL4073562)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM141473(US8921368, 192)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267828(CHEMBL4078773)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267810(CHEMBL4068856)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM21958(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity at gardiquimod stimulated human TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincuba...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM141473(US8921368, 192)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267807(CHEMBL4060536)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267840(CHEMBL4062062)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267836(CHEMBL4105015)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM443496(US10660877, Example 73)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at gardiquimod stimulated human TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50168472(CHEMBL3805348 | US9765060, Compound X)
Affinity DataIC50:  0.800nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267807(CHEMBL4060536)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267837(CHEMBL4060444)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267808(CHEMBL4087655)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267808(CHEMBL4087655)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267797(CHEMBL4080797)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267826(CHEMBL4096145)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM443500(US10660877, Example 77)
Affinity DataIC50:  0.900nMAssay Description:Antagonist activity at gardiquimod stimulated human TRL7 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincuba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267848(CHEMBL4091582)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267840(CHEMBL4062062)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 8(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM442004(US10660877, Example 31)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at R848 stimulated human TRL8 overexpressed in HEK293 cells assessed as inhibition of NF kappa B/Ap-1 activation preincubated wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50035810(CHEMBL3359927)
Affinity DataIC50:  1nMAssay Description:Inhibition of JAK3 (unknown origin) by filter assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239736(CHEMBL4074315 | US10214537, Example 637)
Affinity DataIC50:  1nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267827(CHEMBL4076794)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged JAK1 (unknown origin) after 3 hrs by Caliper assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267839(CHEMBL4076823)
Affinity DataIC50:  1nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267848(CHEMBL4091582)
Affinity DataIC50:  1nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267805(CHEMBL4096795)
Affinity DataIC50:  1nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50261794(CHEMBL4065693)
Affinity DataIC50: <1nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma32P]ATP by top-count liquid scintillation counting ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50533283(CHEMBL4469521)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50509867(CHEMBL4549451)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged JAK3 (unknown origin) using fluoresceinated peptide as substrate measured after 3 hrs by electrophoresis methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM358021(7-(3-(3-(Dimethylamino)oxetan-3-yl)phenyl)-5-(1-(t...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM358021(7-(3-(3-(Dimethylamino)oxetan-3-yl)phenyl)-5-(1-(t...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50533283(CHEMBL4469521)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center (Bbrc)

Curated by ChEMBL
LigandPNGBDBM21958(2-(2,6-dimethylpyridin-4-yl)-3-isopropyl-5-(piperi...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at gardiquimod stimulated TRL7 in human PBMC cells assessed as inhibition of IL-6 production by ELISA analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239744(CHEMBL4071965 | US10214537, Example 643)
Affinity DataIC50:  1.10nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by dibutyryl cyclic adenosine 3', 5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50267798(CHEMBL4091096)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of JAK3 (unknown origin) using CSKtide as substrate after 30 mins in presence of [gamma33P]ATP by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50239752(CHEMBL4067315 | US10214537, Example 585)
Affinity DataIC50:  1.10nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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