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Found 1191 with Last Name = 'sarau' and Initial = 'hm'
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412728(CHEMBL521523)
Affinity DataKi:  0.0316nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human cloned muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345693((3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethy...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345693((3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethy...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381654(CHEMBL2023764)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M2 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine receptor H4(GUINEA PIG)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM22904((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381654(CHEMBL2023764)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M1 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine receptor H4(GUINEA PIG)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM7966(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Affinity DataKi:  0.140nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine receptor H4(GUINEA PIG)
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM22904((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)
Affinity DataKi:  0.150nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM22904((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)
Affinity DataKi:  0.150nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50381654(CHEMBL2023764)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]-N-methyl scopolamine from muscarinic acetylcholine M3 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345693((3-endo)-3-(2-Cyano-2,2-diphenylethyl)-8,8-dimethy...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50071112(CHEMBL56835 | N-[4-(4-Acetylamino-4-phenyl-piperid...)
Affinity DataKi:  0.230nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85083(NKB [MePhe7])
Affinity DataKi:  0.310nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412340(CHEMBL540359)
Affinity DataKi:  0.316nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic acetylcholine M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345692((3-endo)-3-(2,2-Di-2-thienylethenyl)-8,8-dimethyl-...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M1 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345692((3-endo)-3-(2,2-Di-2-thienylethenyl)-8,8-dimethyl-...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M3 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Rattus norvegicus (Rat))
Smithkline Beecham

Curated by ChEMBL
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKi:  0.510nMAssay Description:Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50099628(3-[1,4']Bipiperidinyl-1'-ylmethyl-2-phenyl-quinoli...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50099638(3-(4-Isopropyl-piperazin-1-ylmethyl)-2-phenyl-quin...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50345692((3-endo)-3-(2,2-Di-2-thienylethenyl)-8,8-dimethyl-...)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]N-methyl Scopolamine from human muscarinic M2 receptor expressed in CHO cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM81942(CAS_55582 | NKA | NSC_55582 | Neurokinin alpha | S...)
Affinity DataKi:  0.740nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50052027((E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-phe...)
Affinity DataKi:  0.780nMAssay Description:Inhibition of [3H]-LTB4 binding to human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50099631(3-(4-Morpholin-4-yl-piperidin-1-ylmethyl)-2-phenyl...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50099631(3-(4-Morpholin-4-yl-piperidin-1-ylmethyl)-2-phenyl...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125 I]-[MePhe]-NKB binding to hNK-3-CHO (Chinese hamster ovary) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM81944(CAS_86933-75-7 | NKB | NSC_5311312 | neuromedin K)
Affinity DataKi:  0.810nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50042149(CHEMBL112520 | Lithium; 3-{1-hydroxy-2-[6-(3-hydro...)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]- LTB4 binding on human whole cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50099640(3-[1,4']Bipiperidinyl-1'-ylmethyl-2-phenyl-quinoli...)
Affinity DataKi:  1nMAssay Description:Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50042180(3-{1-Hydroxy-2-[6-(3-hydroxy-undec-1-enyl)-pyridin...)
Affinity DataKi:  1nMAssay Description:Binding affinity of [3H]-LTB4 to receptors on intact human polymorphonuclear leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50051293((S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinol...)
In DepthDetails PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50051293((S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinol...)
Affinity DataKi:  1nMAssay Description:Binding Affinity of [125I]-MePhe7-NKB towards Tachykinin receptor 3-CHO cell membranes(n=3-8)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50074789(3-Amino-2-phenyl-quinoline-4-carboxylic acid ((R)-...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity towards cloned human Tachykinin receptor 3 (hNK-3) expressed in CHO cells using [125I][MePhe7]-NKBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50051290(CHEMBL299377 | N-(1-{3-[1-Benzoyl-3-(3,4-dichloro-...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50099632(3-(4-Isopropyl-piperazin-1-ylmethyl)-2-phenyl-quin...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [125 I]-[MePhe]-NKB binding to hNK-3-CHO (Chinese hamster ovary) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity towards cloned human Tachykinin receptor 3 (hNK-3) expressed in CHO cells using [125I][MePhe7]-NKBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50053354((E)-3-{6-(2,6-Dichloro-phenylsulfanylmethyl)-3-[2-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of [3H]-LTB4 binding to human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50291261((S)-(+)-N-((3-[1-Benzoyl-3-(3,4-dichlorophenyl)pip...)
Affinity DataKi:  1.20nMAssay Description:Binding Affinity of [125I]-MePhe7-NKB towards Tachykinin receptor 3-CHO cell membranes(n=3-8)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50099637(3-(4-Isobutyryl-piperazin-1-ylmethyl)-2-phenyl-qui...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50099643(3-(4-Cyclohexyl-piperazin-1-ylmethyl)-2-phenyl-qui...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [125 I]-[MePhe]-NKB binding to hNK-3-CHO (Chinese hamster ovary) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50053350((E)-3-[3-[2-(4-Chloro-phenyl)-ethoxy]-6-(2,6-dichl...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [3H]-LTB4 binding to human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50053353((E)-3-[6-(2,6-Dichloro-phenylsulfanylmethyl)-3-(3-...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of [3H]-LTB4 binding to human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50051293((S)-(-)-N-(R-ethylbenzyl)-3-hydroxy-2-phenylquinol...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125 I]-[MePhe]-NKB binding to hNK-3-CHO (Chinese hamster ovary) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50099637(3-(4-Isobutyryl-piperazin-1-ylmethyl)-2-phenyl-qui...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125 I]-[MePhe]-NKB binding to hNK-3-CHO (Chinese hamster ovary) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50074791(3-Hydroxy-2-phenyl-quinoline-4-carboxylic acid ((R...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity towards cloned human Tachykinin receptor 3 (hNK-3) expressed in CHO cells using [125I][MePhe7]-NKBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50099626(3-[1,4']Bipiperidinyl-1'-ylmethyl-2-phenyl-quinoli...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [125 I]-[MePhe]-NKB binding to hNK-3-CHO (Chinese hamster ovary) membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50053355((E)-3-{6-(2,6-Dichloro-phenylsulfanylmethyl)-3-[2-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of [3H]-LTB4 binding to human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50099632(3-(4-Isopropyl-piperazin-1-ylmethyl)-2-phenyl-quin...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50053351((E)-3-{6-(2,6-Dichloro-phenylsulfanylmethyl)-3-[4-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of [3H]-LTB4 binding to human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50074785(3-(2-Hydroxy-ethoxy)-2-phenyl-quinoline-4-carboxyl...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity towards cloned human Tachykinin receptor 3 (hNK-3) expressed in CHO cells using [125I][MePhe7]-NKBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50099643(3-(4-Cyclohexyl-piperazin-1-ylmethyl)-2-phenyl-qui...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(GUINEA PIG)
Glaxosmithkline

Curated by PDSP Ki Database
LigandPNGBDBM85845(N-[(S)-1-Phenylpropyl]-2-phenyl-3-(carboxymethoxy)...)
Affinity DataKi:  1.60nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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