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Found 144 with Last Name = 'sekioka' and Initial = 't'
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095523(CHEMBL285231 | [(S)-2-methyl-1-((S)-2-{(S)-2-methy...)
Affinity DataKi:  0.0250nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095523(CHEMBL285231 | [(S)-2-methyl-1-((S)-2-{(S)-2-methy...)
Affinity DataKi:  0.0250nMAssay Description:Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095526(CHEMBL24058 | [(S)-2-methyl-1-((S)-2-{(S)-2-methyl...)
Affinity DataKi:  0.490nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095526(CHEMBL24058 | [(S)-2-methyl-1-((S)-2-{(S)-2-methyl...)
Affinity DataKi:  0.490nMAssay Description:Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095530((S)-2-(5-amino-2-(4-fluorophenyl)-6-oxopyrimidin-1...)
Affinity DataKi:  0.520nMAssay Description:Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095530((S)-2-(5-amino-2-(4-fluorophenyl)-6-oxopyrimidin-1...)
Affinity DataKi:  0.520nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095521((S)-2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimi...)
Affinity DataKi:  0.640nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095521((S)-2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimi...)
Affinity DataKi:  0.640nMAssay Description:Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095519((S)-2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimi...)
Affinity DataKi:  1.18nMAssay Description:Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095519((S)-2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimi...)
Affinity DataKi:  1.18nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095525((S)-2-(5-amino-2-(4-fluorophenyl)-6-oxopyrimidin-1...)
Affinity DataKi:  1.37nMAssay Description:Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095525((S)-2-(5-amino-2-(4-fluorophenyl)-6-oxopyrimidin-1...)
Affinity DataKi:  1.37nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098818(2-{3-Methyl-2-[(pyridine-3-carbonyl)-amino]-butyry...)
Affinity DataKi:  1.66nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098833(2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-...)
Affinity DataKi:  2.25nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098827(2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-N-{2-...)
Affinity DataKi:  2.55nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098817(2-[2-(4-Fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-...)
Affinity DataKi:  3.35nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095527((S)-2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-N...)
Affinity DataKi:  3.59nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095527((S)-2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-N...)
Affinity DataKi:  3.59nMAssay Description:Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098830(1-{3-Methyl-2-[(pyridine-3-carbonyl)-amino]-butyry...)
Affinity DataKi:  5.10nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095520((S)-2-(5-amino-2-(4-fluorophenyl)-6-oxopyrimidin-1...)
Affinity DataKi:  6.38nMAssay Description:Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095520((S)-2-(5-amino-2-(4-fluorophenyl)-6-oxopyrimidin-1...)
Affinity DataKi:  6.38nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098823(2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-...)
Affinity DataKi:  6.76nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098826(2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-N-{2-...)
Affinity DataKi:  8.75nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098821(2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-...)
Affinity DataKi:  10.7nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095529(2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-...)
Affinity DataKi:  11.8nMAssay Description:Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095529(2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-...)
Affinity DataKi:  11.8nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098815(1-(2-Methanesulfonylamino-3-methyl-butyryl)-pyrrol...)
Affinity DataKi:  12nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095522(2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-N-[1-...)
Affinity DataKi:  12.2nMAssay Description:Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095522(2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-N-[1-...)
Affinity DataKi:  12.2nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098824(2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-...)
Affinity DataKi:  13.9nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098819(2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-...)
Affinity DataKi:  14nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095524((S)-2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimi...)
Affinity DataKi:  15.3nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095524((S)-2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimi...)
Affinity DataKi:  15.3nMAssay Description:Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098816(2-(5-Amino-6-oxo-2-pyridin-3-yl-6H-pyrimidin-1-yl)...)
Affinity DataKi:  16.6nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098828(2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-...)
Affinity DataKi:  21.2nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098832(CHEMBL282947 | N-[1-(5-tert-Butyl-[1,3,4]oxadiazol...)
Affinity DataKi:  23.5nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098822(2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-...)
Affinity DataKi:  24.8nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098814(CHEMBL277194 | N-{2-Methyl-1-[5-(1-methyl-cyclopro...)
Affinity DataKi:  26.4nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095528(2-(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-N-[1-...)
Affinity DataKi:  29.1nMAssay Description:Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098812(2-[2-(4-Fluoro-phenyl)-6-oxo-6H-pyrimidin-1-yl]-N-...)
Affinity DataKi:  43.8nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095518((S)-N-[1-(5-tert-Butyl-[1,3,4]oxadiazole-2-carbony...)
Affinity DataKi:  44.3nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50095518((S)-N-[1-(5-tert-Butyl-[1,3,4]oxadiazole-2-carbony...)
Affinity DataKi:  44.3nMAssay Description:Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098831(CHEMBL23952 | N-[1-(5-tert-Butyl-[1,3,4]oxadiazole...)
Affinity DataKi:  57.8nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098834(1-(3H-Imidazole-4-carbonyl)-2,3-dihydro-1H-indole-...)
Affinity DataKi:  79.7nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50036093(2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-...)
Affinity DataKi:  101nMAssay Description:Inhibition of human neutrophil elastase HNE, hydrolysis of MeO-Suc-Ala-Ala-Pro-Val-pNaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50036093(2-[5-Amino-2-(4-fluoro-phenyl)-6-oxo-6H-pyrimidin-...)
Affinity DataKi:  101nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098820(2-[1-(5-tert-Butyl-[1,3,4]oxadiazole-2-carbonyl)-2...)
Affinity DataKi:  114nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098836(CHEMBL24260 | N-[1-(5-tert-Butyl-[1,3,4]oxadiazole...)
Affinity DataKi:  163nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50041292((S)-1-((S)-2-Acetylamino-propionyl)-pyrrolidine-2-...)
Affinity DataKi:  210nMAssay Description:Inhibitory activity against human neutrophil elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Cortech

Curated by ChEMBL
LigandPNGBDBM50098837(2-(3H-Imidazole-4-carbonyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataKi:  309nMAssay Description:Binding constant derived from inhibition of elastase catalyzed hydrolysis of synthetic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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