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Found 562 with Last Name = 'stauffer' and Initial = 'tm'
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169371(1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclopropylmethyl-...)
Affinity DataKi:  0.170nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169377(1-[4-(3'-Cyano-biphenyl-4-yl)-1-propyl-piperidin-4...)
Affinity DataKi:  0.310nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331916((S)-2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihy...)
Affinity DataKi:  0.400nMAssay Description:Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169374(1-[4-(3'-Cyano-biphenyl-4-yl)-1-(2-methoxy-ethyl)-...)
Affinity DataKi:  0.410nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331917((R)-N-(2-hydroxy-1-phenylethyl)-2-(2-oxo-4-pheneth...)
Affinity DataKi:  0.440nMAssay Description:Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169390(1-[4-(3'-Cyano-biphenyl-4-yl)-1-isopropyl-piperidi...)
Affinity DataKi:  0.450nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169389(1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclopentyl-piperi...)
Affinity DataKi:  0.630nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168805(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)
Affinity DataKi:  0.840nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168812(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)
Affinity DataKi:  0.880nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169393(1-(4-Chloro-3-trifluoromethyl-phenyl)-3-[4-(3'-cya...)
Affinity DataKi:  0.980nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168825(1-(3-Chloro-4-fluoro-phenyl)-3-[2-(3'-cyano-biphen...)
Affinity DataKi:  0.980nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331914(2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroq...)
Affinity DataKi:  1nMAssay Description:Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50236065((R)-3-(2-(1-(3-fluoro-5-methylphenyl)-2-methylprop...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]IL8 from human CXCR2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168791(1-(3-Chloro-phenyl)-3-[2-(3'-cyano-biphenyl-4-yl)-...)
Affinity DataKi:  1.10nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168800(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)
Affinity DataKi:  1.20nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169382(1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclohexyl-piperid...)
Affinity DataKi:  1.20nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331913(2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroq...)
Affinity DataKi:  1.30nMAssay Description:Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169376(1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4...)
Affinity DataKi:  1.40nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169396(1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4...)
Affinity DataKi:  1.40nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169386(1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4...)
Affinity DataKi:  1.5nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50236057((R)-3-(2-(1-(3-fluoro-4-methoxyphenyl)-2-methylpro...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [125I]IL8 from human CXCR2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331911((S)-2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihy...)
Affinity DataKi:  1.70nMAssay Description:Antagonist activity at adenosien A2B receptor in human HMC-1 cells assessed as inhibition of NECA-induced IL-8 release after 6 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50236066((R)-3-(2-(1-(3,5-difluorophenyl)propylamino)-3,4-d...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [125I]IL8 from human CXCR2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50236050((R)-3-(2-(1-(3-cyano-5-fluorophenyl)propylamino)-3...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [125I]IL8 from human CXCR2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50236064((R)-3-(2-(1-(3,5-difluorophenyl)-2-methylpropylami...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [125I]IL8 from human CXCR2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50236068((R)-3-(2-(1-(3-cyano-5-methylphenyl)propylamino)-3...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [125I]IL8 from human CXCR2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169387(CHEMBL366703 | N-(4'-{4-[3-(3,5-Dichloro-phenyl)-u...)
Affinity DataKi:  2.10nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169388(1-(3,5-Dichloro-phenyl)-3-[1-methanesulfonyl-4-(4-...)
Affinity DataKi:  2.20nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169398(1-[4-(3'-Cyano-biphenyl-4-yl)-1-methyl-piperidin-4...)
Affinity DataKi:  2.20nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168823(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)
Affinity DataKi:  2.40nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329367(2-(3-cyanobenzamido)-N-isopropyl-3-(3-methoxypropy...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]SCH58261 from human recombinant A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168802(1-[2-(3'-Cyano-biphenyl-4-yl)-4-methylamino-butyl]...)
Affinity DataKi:  2.60nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169370(1-[4-(3'-Cyano-biphenyl-4-yl)-1-ethyl-piperidin-4-...)
Affinity DataKi:  2.60nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169392(1-[4-(3'-Chloro-biphenyl-4-yl)-1-methyl-piperidin-...)
Affinity DataKi:  2.60nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331917((R)-N-(2-hydroxy-1-phenylethyl)-2-(2-oxo-4-pheneth...)
Affinity DataKi:  2.80nMAssay Description:Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50236059((R)-3-(2-(1-(3-fluoro-5-methylphenyl)propylamino)-...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [125I]IL8 from human CXCR2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168810(1-[2-(3'-Cyano-biphenyl-4-yl)-4-cyclopentylamino-b...)
Affinity DataKi:  3nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168810(1-[2-(3'-Cyano-biphenyl-4-yl)-4-cyclopentylamino-b...)
Affinity DataKi:  3nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50169391(1-(3,5-Dichloro-phenyl)-3-[1-methyl-4-(4-pyridin-3...)
Affinity DataKi:  3.10nMAssay Description:Ability to displace [125-I]-MCH()0.5 nM from human MCH1R(2.5 uM) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329364(2-(3-cyanobenzamido)-N,N-diethyl-1-(3-methoxypropy...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]SCH58261 from human recombinant A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50248433(2-(cyclopropylamino)-7-(2,6-difluorobenzyl)-9-(3-m...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]SCH-58261 from human recombinant adenosine A2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50329367(2-(3-cyanobenzamido)-N-isopropyl-3-(3-methoxypropy...)
Affinity DataKi:  4.30nMAssay Description:Antagonist activity at rat A2A receptor by cAMP functional assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168799(1-[2-(3'-Cyano-biphenyl-4-yl)-4-ethylamino-butyl]-...)
Affinity DataKi:  4.30nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50236062((R)-2-hydroxy-N,N-dimethyl-3-(2-(2-methyl-1-(3-met...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [125I]IL8 from human CXCR2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331914(2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroq...)
Affinity DataKi:  4.5nMAssay Description:Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50236052((R)-3-(2-(cyclopropyl(3,5-difluorophenyl)methylami...)
Affinity DataKi:  4.5nMAssay Description:Displacement of [125I]IL8 from human CXCR2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50236053((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [125I]IL8 from human CXCR2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Pharmacopeia Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50168797(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)
Affinity DataKi:  4.70nMAssay Description:Inhibitiory constant towards Human melanin-concentrating hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331913(2-(2-oxo-4-phenethyl-3-(thiazol-2-yl)-1,2-dihydroq...)
Affinity DataKi:  5.10nMAssay Description:Antagonist activity at human adenosine A2B receptor transfected in CHO cells assessed as inhibition of NECA-induced cAMP accumulation treated 15 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50236061((R)-3-(2-(1-(3-fluoro-4-methoxyphenyl)propylamino)...)
Affinity DataKi:  5.20nMAssay Description:Displacement of [125I]IL8 from human CXCR2 by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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