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Found 1585 with Last Name = 'wilson' and Initial = 'sj'
TargetHrh3 protein(RAT)
R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM22911(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHrh3 protein(RAT)
R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM22911(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50209809(4-(3-(dimethylamino)-1-(4-(3-(piperidin-1-yl)propo...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50346209(5-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azep...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217586(CHEMBL442080 | N-(4-(3-((methylamino)methyl)-4-(4-...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM22911(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHrh3 protein(RAT)
R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM22541(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  0.400nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217584((5-(4-(4-isopropylpiperazin-1-yl)butyl)-2-(4-(meth...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217575(4-(4-(3-((methylamino)methyl)-4-(4-(methylthio)phe...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM22542(4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50410342(CHEMBL195408)
Affinity DataKi:  0.447nMAssay Description:Mean binding affinity for human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHrh3 protein(RAT)
R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM22542(4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50371305(CHEMBL272077)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50177731(CHEMBL204872 | dimethyl-{2-[4-(3-piperidin-1-yl-pr...)
Affinity DataKi:  0.5nMAssay Description:Displacement of N-[3H]methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHrh3 protein(RAT)
R. W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM22541(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM22530(N(alpha)-Methylhistamine | N-alpha-methylhistamine...)
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217593((5-bromo-2-(4-(methylthio)phenoxy)phenyl)-N-methyl...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217592((5-(4-(4-isopropylpiperazin-1-yl)but-1-ynyl)-2-(4-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  0.560nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM22541(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)
Affinity DataKi:  0.600nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217579((5-(4-(4-fluoropiperidin-1-yl)but-1-ynyl)-2-(4-(me...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50209802(CHEMBL438490 | N,N-dimethyl-3-phenoxy-3-(4-(3-(pip...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM22911(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Affinity DataKi:  0.600nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217590((5-(4-(4-cyclopropylpiperazin-1-yl)butyl)-2-(4-(me...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50410347(CHEMBL194441)
Affinity DataKi:  0.631nMAssay Description:Mean binding affinity for human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM22904((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50206229(3-(9-(3-(piperidin-1-yl)propoxy)-1,2,3,5,6,10b-hex...)
Affinity DataKi:  0.700nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in SK-N-MC cells assessed as effect on cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216250((6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(thiophe...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50216250((6R,10bR)-9-(3-(piperidin-1-yl)propoxy)-6-(thiophe...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217572(CHEMBL393036 | N-methyl(2-(4-(methylthio)phenoxy)-...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217565((5-(4-(4-isopropyl-1,4-diazepan-1-yl)but-1-ynyl)-2...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217572(CHEMBL393036 | N-methyl(2-(4-(methylthio)phenoxy)-...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217589((6S,10bR)-6-(4-methoxyphenyl)-9-(3-(piperidin-1-yl...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50209810(CHEMBL245516 | N,N-dimethyl-3-(4-(3-(piperidin-1-y...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50209806(CHEMBL245307 | N,N-dimethyl-3-phenyl-3-(3-(3-(pipe...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50209815(3-(3-methoxyphenoxy)-N,N-dimethyl-3-(4-(3-(piperid...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity at human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50346205(5-Piperidin-1-ylmethyl-2-(3-piperidin-1-yl-propoxy...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM22904((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity to the human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50371294(CHEMBL257208)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217589((6S,10bR)-6-(4-methoxyphenyl)-9-(3-(piperidin-1-yl...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50209802(CHEMBL438490 | N,N-dimethyl-3-phenoxy-3-(4-(3-(pip...)
Affinity DataKi:  0.720nMAssay Description:Binding affinity at human histamine H3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50198598(CHEMBL396945 | N-ethyl-3-(4-(4-methoxyphenyl)-2-me...)
Affinity DataKi:  0.730nMAssay Description:Binding affinity to rat SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50410346(CHEMBL372471)
Affinity DataKi:  0.741nMAssay Description:Mean binding affinity for human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50371290(CHEMBL401683)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50217576(CHEMBL236046 | N-methyl(2-(4-(methylthio)phenoxy)-...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50371289(CHEMBL258349)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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