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Found 97 Enz. Inhib. hit(s) with Target = 'Caspase-2'
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM221(5-{[(5-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl...)
Affinity DataKi:  960nM ΔG°:  -34.3kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10323((S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]s...)
Affinity DataKi:  4.00E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10318((S)-5-{1-[2-(Phenoxymethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi:  4.90E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10315((S)-5-{1-[2-(Anilinomethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi:  6.50E+3nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM220(5-{[(4-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl...)
Affinity DataKi:  9.00E+3nM ΔG°:  -28.8kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM222((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  1.10E+4nM ΔG°:  -28.3kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10316((R)-5-{1-[2-(Anilinomethyl)pyrrolidinyl]sulfonyl}i...)
Affinity DataKi:  1.10E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM224((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  1.60E+4nM ΔG°:  -27.4kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM225((S)-5-5-(1-Carboxymethyl-2-oxo-ethylcarbamoyl)-thi...)
Affinity DataKi:  2.10E+4nM ΔG°:  -26.7kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10305((S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isa...)
Affinity DataKi: >2.50E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10298(1-benzyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi: >2.50E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50200932((3S)-3-[(2S)-6-(6-{5-[(3aS,6aR)-2-oxo-hexahydro-1H...)
Affinity DataKi:  2.90E+4nMAssay Description:Inhibition of human caspase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM223((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  3.00E+4nM ΔG°:  -25.8kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM219(5-({[(5-{[(2S)-1-carboxy-4-{[(2-chlorophenyl)methy...)
Affinity DataKi:  3.00E+4nM ΔG°:  -25.8kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM227((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  3.70E+4nM ΔG°:  -25.3kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10309(5-(pyrrolidine-1-sulfonyl)-2,3-dihydro-1H-indole-2...)
Affinity DataKi: >5.00E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10297(1-methyl-5-nitro-2,3-dihydro-1H-indole-2,3-dione |...)
Affinity DataKi: >5.00E+4nMAssay Description:The substrate peptides terminating in AMC/AFC are processed by caspases with or without inhibitors, and the accumulation of AMC/AFC was assessed with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM226((S)-5-({5-[1-Carboxymethyl-3-(2-chloro-benzylsulfa...)
Affinity DataKi:  6.40E+4nM ΔG°:  -23.9kJ/molepH: 7.4 T: 2°CAssay Description:The effectiveness of compounds against the activity of human recombinant caspase-1-8 was measured using fluorometric assays. Assays were carried out ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50160974(CHEMBL366927 | [3-(2-{5-tert-Butyl-3-[(4-methyl-fu...)
Affinity DataIC50: >10nMAssay Description:Inhibitory concentration against casp-2 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50160957(CHEMBL179503 | [3-(2-{5-tert-Butyl-3-[(4-methyl-fu...)
Affinity DataIC50: >10nMAssay Description:Inhibitory concentration against casp-2 in neuronal precursor (NT2) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355101(CHEMBL1835324)
Affinity DataIC50:  22nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355110(CHEMBL1835208)
Affinity DataIC50:  41nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355111(CHEMBL1835210)
Affinity DataIC50:  41nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355109(CHEMBL1835209)
Affinity DataIC50:  46nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355103(CHEMBL1835399)
Affinity DataIC50:  50nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355094(CHEMBL1835317)
Affinity DataIC50:  50nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355102(CHEMBL1835325)
Affinity DataIC50:  60nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355099(CHEMBL1835322)
Affinity DataIC50:  86nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355112(CHEMBL1835211)
Affinity DataIC50:  108nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355097(CHEMBL1835320)
Affinity DataIC50:  136nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355098(CHEMBL1835321)
Affinity DataIC50:  150nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355107(CHEMBL1835403)
Affinity DataIC50:  163nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355093(CHEMBL1835316)
Affinity DataIC50:  219nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10284(4-Oxo-4-piperidin-1-yl-N-(1,3,4-trioxo-1,2,3,4-tet...)
Affinity DataIC50:  231nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10264(2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydro...)
Affinity DataIC50:  233nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355089(CHEMBL1835212)
Affinity DataIC50:  246nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355090(CHEMBL1835313)
Affinity DataIC50:  413nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355095(CHEMBL1835318)
Affinity DataIC50:  441nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355091(CHEMBL1835314)
Affinity DataIC50:  453nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355106(CHEMBL1835402)
Affinity DataIC50:  459nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10278(3-Chloro-N-(1,2,3,4-tetrahydro-1,3,4-trioxoisoquin...)
Affinity DataIC50:  530nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10287(Isoquinoline-1,3,4-trione 13f | N-(2-Methoxy-pheny...)
Affinity DataIC50:  537nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355108(CHEMBL1835404)
Affinity DataIC50:  573nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355111(CHEMBL1835210)
Affinity DataIC50:  635nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355092(CHEMBL1835315)
Affinity DataIC50:  772nMAssay Description:Inhibition of caspase-2 (amino acids 170 to 452) using Ac-VDVAD-AMC coumarin-120 as substrate after 20 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355098(CHEMBL1835321)
Affinity DataIC50:  781nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10280(3-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-y...)
Affinity DataIC50:  859nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355099(CHEMBL1835322)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM50355109(CHEMBL1835209)
Affinity DataIC50:  1.33E+3nMAssay Description:Inhibition of human Myc-DDK tagged caspase-2 expressed in HEK293 T17 cells using Ac-VDVAD-AMC coumarin-120 as substrate pre-incubated for 2 hrs measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Sunesis Pharmaceuticals

LigandPNGBDBM10247(1,2,3,4-tetrahydroisoquinoline-1,3,4-trione | Isoq...)
Affinity DataIC50:  1.53E+3nMAssay Description:The rate of chromogenic substrate hydrolysis was monitored by the change of absorbance at 405 nm for 3 min. Compounds were tested in duplicate. The I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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