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Found 1382 Enz. Inhib. hit(s) with Target = 'Histamine H2 receptor'
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM81543(Alpha-Dimethylhistane-alpha | CAS_195960 | NSC_195...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM81541(CAS_195530 | NSC_195530 | S-Beta-Dimethylhistamine...)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM50406642(CHEMBL72193)
Affinity DataKi:  0.708nMAssay Description:Inhibition of [125I]APT binding to histamine H2 receptor in guinea pig cerebral membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM81542(Beta-Methylhistamine | CAS_565544 | NSC_565544)
Affinity DataKi:  0.900nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM22904((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50253754(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N-m...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]tiotidine from human histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50568741(CHEMBL4875600)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor expressed in sf9 insect cell membranes co-expressing GSalphaS incubated for 60 mins by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM50406643(CHEMBL73994)
Affinity DataKi:  2.60nMAssay Description:Inhibition of [125I]APT binding to H2 receptors in guinea pig cerebral membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50601551(CHEMBL5207281)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM50404821(CHEMBL306465)
Affinity DataKi:  4nMAssay Description:In vitro inhibition of Histamine H2 receptor by measuring its ability to block the histamine-stimulated adenylate cyclase of guinea pig hippocampal h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50568740(CHEMBL4860528)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor expressed in sf9 insect cell membranes co-expressing GSalphaS incubated for 60 mins by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50315205((R)-2-(6-fluoro-3-(1-(3-methoxypyrazin-2-yl)ethyl)...)
Affinity DataKi:  4.5nMAssay Description:Inhibition of H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50601590(CHEMBL5173079)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50601567(CHEMBL5206565)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50601556(CHEMBL5200771)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM50229612(CHEMBL304608)
Affinity DataKi:  5.20nMAssay Description:Inhibition of [125I]APT binding to H2 receptors in guinea pig cerebral membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50601589(CHEMBL5176229)
Affinity DataKi:  5.20nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM50229613(ICI-125211 | Tiotidine)
Affinity DataKi:  5.60nMAssay Description:Inhibition of [125I]APT binding to H2 receptors in guinea pig cerebral membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50445613(Asenapine maleate | CHEBI:71246 | ORG-5222 | Saphr...)
Affinity DataKi:  5.70nMAssay Description:Displacement of [3H]Cimetidine from histamine H2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50445613(Asenapine maleate | CHEBI:71246 | ORG-5222 | Saphr...)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]Cimetidine from histamine H2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50601572(CHEMBL5208722)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM50404822(CHEMBL8982)
Affinity DataKi:  6.30nMAssay Description:In vitro inhibition of Histamine H2 receptor by measuring its ability to block the histamine-stimulated adenylate cyclase of guinea pig hippocampal h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM50404823(CHEMBL63299)
Affinity DataKi:  6.30nMAssay Description:In vitro inhibition of Histamine H2 receptor by measuring its ability to block the histamine-stimulated adenylate cyclase of guinea pig hippocampal h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50601577(CHEMBL5180504)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50601576(CHEMBL5184911)
Affinity DataKi:  8.10nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM86740(UR-AK24 | UR-AK57)
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM50406645(AMINOPOTENTIDINE)
Affinity DataKi:  9.80nMAssay Description:muscarinic acetylcholine receptor M3-antagonistic activity on the isolated guinea pig ileum determined by Schild plot.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50568759(CHEMBL4865965)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor expressed in sf9 insect cell membranes co-expressing GSalphaS incubated for 60 mins by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM22891(3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-y...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM50406644(CHEMBL307952)
Affinity DataKi:  12nMAssay Description:Inhibition of [125I]APT binding to histamine H2 receptor in guinea pig cerebral membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM86740(UR-AK24 | UR-AK57)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50543277(CHEMBL4642548)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]UR-DE257 from Gsalphas-coupled human H2R expressed in baculovirus infected Sf9 cells incubated for 60 mins by scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50601573(CHEMBL5208845)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50543278(CHEMBL4644794)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]UR-DE257 from Gsalphas-coupled human H2R expressed in baculovirus infected Sf9 cells incubated for 60 mins by scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50601583(CHEMBL5198795)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM86742(UR-AK64)
Affinity DataKi:  16nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50543289(CHEMBL4643501)
Affinity DataKi:  16nMAssay Description:Binding affinity to human H2R expressing Sf9 cells incubated for 60 mins by microbeta scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(RAT)
Boehringer Ingelheim Italia

Curated by PDSP Ki Database
LigandPNGBDBM7966(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Affinity DataKi:  17nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50543281(CHEMBL4644467)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]UR-DE257 from Gsalphas-coupled human H2R expressed in baculovirus infected Sf9 cells incubated for 60 mins by scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM22568(1-cyano-3-{2-[({2-[(diaminomethylidene)amino]-1,3-...)
Affinity DataKi:  18nMAssay Description:Displacement of [125I]Aminopotentidine from human recombinant histamine H2 receptor expressed in CHOK1 cells after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50568739(CHEMBL4856059)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor expressed in sf9 insect cell membranes co-expressing GSalphaS incubated for 60 mins by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50543279(CHEMBL4641916)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]UR-DE257 from Gsalphas-coupled human H2R expressed in baculovirus infected Sf9 cells incubated for 60 mins by scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50601563(CHEMBL5204599)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]UR-DE257 from human histamine H2 receptor stably expressed in baculovirus infected Sf9 cell membrane co-expressing RG-Salpha S in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50543280(CHEMBL4637893)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]UR-DE257 from Gsalphas-coupled human H2R expressed in baculovirus infected Sf9 cells incubated for 60 mins by scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50543283(CHEMBL4647775)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]UR-DE257 from Gsalphas-coupled human H2R expressed in baculovirus infected Sf9 cells incubated for 60 mins by scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM86738(UR-AK46)
Affinity DataKi:  21nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM86747(UR-AK67)
Affinity DataKi:  21nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Queen'S Medical Centre

Curated by PDSP Ki Database
LigandPNGBDBM86743(UR-AK49)
Affinity DataKi:  22nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50586669(CHEMBL5094663)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]UR-DE257 from Gsalphas-coupled human H2R expressed in Sf9 cell membranes by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM86742(UR-AK64)
Affinity DataKi:  23nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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