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Found 374 Enz. Inhib. hit(s) with Target = 'Huntingtin'
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50578375(CHEMBL4875017)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of endogenous Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by ELISA-based MS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50578380(CHEMBL4878942)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of endogenous Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by ELISA-based MS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50578377(CHEMBL4847156)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of endogenous Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by ELISA-based MS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50578376(CHEMBL4863336)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of endogenous Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by ELISA-based MS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50578378(CHEMBL4867927)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of endogenous Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by ELISA-based MS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50578379(CHEMBL4859053)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of endogenous Huntingtin protein (unknown origin) incubated for overnight in presence of MW1/MAB2166 monoclonal antibody by ELISA-based MS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50595435(CHEMBL5179682)
Affinity DataIC50:  8nMAssay Description:Inhibition of HTT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM37533((2E,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylene...)
Affinity DataIC50: <10nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM37535(CHLORTETRACYCLINE HYDROCHLORIDE | MLS000069428 | S...)
Affinity DataIC50: <10nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50595433(CHEMBL5195936)
Affinity DataIC50:  40nMAssay Description:Inhibition of HTT (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50595434(CHEMBL5175104)
Affinity DataIC50:  80nMAssay Description:Inhibition of HTT (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM32023((2E,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylene...)
Affinity DataIC50:  80nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM37536((2E,4S,4aR,5S,5aR,6S,12aS)-2-[amino(hydroxy)methyl...)
Affinity DataIC50: <100nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM37534((2E,4R,12aR)-2-[amino(hydroxy)methylene]-4,7-bis(d...)
Affinity DataIC50: <100nMAssay Description:The mutation underlying Huntington's disease is an expansion of a polyglutamine tract in the N-terminus of the protein huntingtin (htt). Under no...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM96500(MLS001157845 | N'-[(1E)-1-(1-cyclohexyl-2,4,6-trik...)
Affinity DataIC50:  450nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM96499(MLS001158344 | N'-[(1Z)-1-(1-cyclohexyl-2,4,6-trik...)
Affinity DataIC50:  452nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM96534(MLS003118514 | N-(5-chloranylthiophen-2-yl)sulfony...)
Affinity DataIC50:  462nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM96471(3-[(2E)-2-(1-cyano-2-oxo-2-phenylethylidene)hydraz...)
Affinity DataIC50:  561nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM64759(3-(furan-2-carbonyl)-4-hydroxy-1-(6-methyl-1,3-ben...)
Affinity DataIC50:  624nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM58741(2-[3-hydroxy-2-keto-4-(5-methyl-2-furoyl)-5-(4-nit...)
Affinity DataIC50:  636nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50257650(4-(2-(6-chloroquinazolin-4-ylamino)ethyl)phenol | ...)
Affinity DataIC50:  710nMAssay Description:Inhibition of Huntingtin protein aggregation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50256((5E)-1-butyl-5-[(E)-3-(2-furanyl)prop-2-enylidene]...)
Affinity DataIC50:  721nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM48867((5Z)-2,6-diketo-4-methyl-5-[[5-(4-methyl-2-nitro-p...)
Affinity DataIC50:  784nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM96419(6-chloranyl-N-[2-(2-chlorophenyl)ethyl]-5-methyl-7...)
Affinity DataIC50:  796nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM53725(MLS000035506 | N-[(5Z)-5-(4,5-dimethoxy-2-nitro-be...)
Affinity DataIC50:  848nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM90877(3-[(3-fluorobenzoyl)amino]-5-phenyl-2-thenoic acid...)
Affinity DataIC50:  859nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM53935(4-methyl-N-[(5Z)-4-oxidanylidene-5-(phenylmethylid...)
Affinity DataIC50:  879nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM61891(1-(6-Chloro-benzothiazol-2-yl)-4-(furan-2-carbonyl...)
Affinity DataIC50:  987nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM96413(6-(2-furanyl)-3-methyl-1-phenyl-4-pyrazolo[3,4-b]p...)
Affinity DataIC50:  1.01E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM96462(2-[(6E)-1-benzyl-2,4,5-triketo-6-p-anisylidene-7H-...)
Affinity DataIC50:  1.01E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM70228(3-[5-[(Z)-(5-azanylidene-7-oxidanylidene-3-propan-...)
Affinity DataIC50:  1.06E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM54149(5-(3-thienyl)-3-({[4-(trifluoromethyl)phenyl]sulfo...)
Affinity DataIC50:  1.06E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50257498(4-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-y...)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of Huntingtin protein aggregation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM46036(2-[[3-(3-keto-1,2-benzothiazol-2-yl)phenyl]sulfony...)
Affinity DataIC50:  1.10E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM46215(2-[4-[[5-(4-chlorophenyl)-6-isopropoxycarbonyl-3-k...)
Affinity DataIC50:  1.11E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50257649(4-(2-(6-bromoquinazolin-4-ylamino)ethyl)phenol | C...)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of Huntingtin protein aggregation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM96446(MLS000391903 | SMR000260936 | cid_2318621)
Affinity DataIC50:  1.12E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM60895(4-[3-[(5Z)-5-(2-furfurylidene)-4-keto-2-thioxo-thi...)
Affinity DataIC50:  1.18E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM75042((6Z)-5-imino-6-(1H-indol-3-ylmethylene)-3-(methyls...)
Affinity DataIC50:  1.19E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM66209(3-(1-benzofuran-2-carbonyl)-2-(3-chlorophenyl)-4-h...)
Affinity DataIC50:  1.19E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50430741(CHEMBL2333942)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of HD exon 1 fusion protein with 51 glutamine residues (unknown origin) aggregation expressed in Escherichia coli SURE after 16 hrs by Wes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM96523(Cefotaxime sodium salt | MLS002222330 | SMR0013072...)
Affinity DataIC50:  1.21E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM96424(5-(butylcarbamoyl)-3-(naphthalen-1-ylsulfanylmethy...)
Affinity DataIC50:  1.21E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM96519(4-chloranyl-2-[2-[4-[(4-fluorophenyl)sulfonyl-meth...)
Affinity DataIC50:  1.24E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50258237(6-bromo-4-(4-methylpiperazin-1-yl)quinazoline | CH...)
Affinity DataIC50:  1.31E+3nMAssay Description:Inhibition of Huntingtin protein aggregation by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM96417(5-(4-methyl-1-naphthalenyl)-N-(4-methylphenyl)sulf...)
Affinity DataIC50:  1.34E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM96537(1-[1-(4-chlorophenyl)cyclobutanecarbonyl]-2-methyl...)
Affinity DataIC50:  1.37E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM96536(MLS003121794 | N-[3-(difluoromethoxy)phenyl]sulfon...)
Affinity DataIC50:  1.45E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM61059(2-[5-(2,5-Dichloro-phenyl)-furan-2-yl]-6-mercapto-...)
Affinity DataIC50:  1.47E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHuntingtin(Homo sapiens (Human))
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM96507(4,5-dimethoxy-2-[({4-[(methylanilino)sulfonyl]-2-t...)
Affinity DataIC50:  1.48E+3nMMore data for this Ligand-Target Pair
In DepthDetails PCBioAssay
Displayed 1 to 50 (of 374 total ) | Next | Last >>
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