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Found 511 Enz. Inhib. hit(s) with Target = 'Integrin alpha-4/beta-7'
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM314067(US9610264, Compound 4)
Affinity DataIC50:  0.270nMAssay Description:The studies began by screening for the optimal protein concentrations for the method. The studies were conducted in goat anti-mouse IgG coated black ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM314059(US9610264, Compound 1)
Affinity DataIC50:  0.330nMAssay Description:The studies began by screening for the optimal protein concentrations for the method. The studies were conducted in goat anti-mouse IgG coated black ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM314070(US9610264, Compound 6)
Affinity DataIC50:  0.460nMAssay Description:The studies began by screening for the optimal protein concentrations for the method. The studies were conducted in goat anti-mouse IgG coated black ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM16839((2S)-3-{4-[(3,5-dichloropyridine-4-)amido]phenyl}-...)
Affinity DataIC50:  0.600nMT: 2°CAssay Description:M2 anti-FLAG antibody coated 96-well plates were coated with recombinant FLAG-hMAdCAM-1 contained in Dulbecco PBS. The compounds to be tested were ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM314068(US9610264, Compound 5)
Affinity DataIC50:  0.610nMAssay Description:The studies began by screening for the optimal protein concentrations for the method. The studies were conducted in goat anti-mouse IgG coated black ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM314068(US9610264, Compound 5)
Affinity DataIC50:  0.640nMAssay Description:The studies began by screening for the optimal protein concentrations for the method. The studies were conducted in goat anti-mouse IgG coated black ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM16801((2S)-2-[(2,6-dichlorophenyl)formamido]-3-[4-(2,6-d...)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of [125I]MAdCAM-Ig binding to alpha4-beta7 integrin of human RPMI-8866 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM314065(US9610264, Compound 2)
Affinity DataIC50:  0.890nMAssay Description:The studies began by screening for the optimal protein concentrations for the method. The studies were conducted in goat anti-mouse IgG coated black ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM314071(US9610264, Compound 7)
Affinity DataIC50:  0.980nMAssay Description:The studies began by screening for the optimal protein concentrations for the method. The studies were conducted in goat anti-mouse IgG coated black ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM314072(US9610264, Compound 8)
Affinity DataIC50:  1.23nMAssay Description:The studies began by screening for the optimal protein concentrations for the method. The studies were conducted in goat anti-mouse IgG coated black ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM314074(US9610264, Compound 9)
Affinity DataIC50:  1.53nMAssay Description:The studies began by screening for the optimal protein concentrations for the method. The studies were conducted in goat anti-mouse IgG coated black ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM314075(US9610264, Compound 10)
Affinity DataIC50:  1.64nMAssay Description:The studies began by screening for the optimal protein concentrations for the method. The studies were conducted in goat anti-mouse IgG coated black ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50108331(CHEMBL44204 | Pyrrolidine-1-carboxylic acid 4-((S)...)
Affinity DataIC50:  1.90nMAssay Description:Alpha4-beta7 integrin binding affinity was determined in duplicate by a radioligand binding assay using [125I]-VCAM-Ig and a suspension of RPMI-8866 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM16812((2S)-2-[(2,6-dichlorophenyl)formamido]-3-[4-(5-eth...)
Affinity DataIC50:  2nMT: 2°CAssay Description:M2 anti-FLAG antibody coated 96-well plates were coated with recombinant FLAG-hMAdCAM-1 contained in Dulbecco PBS. The compounds to be tested were ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50372987(CHEMBL258255)
Affinity DataIC50:  2nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM16809((2S)-2-[(2,6-dichlorophenyl)formamido]-3-{4-[2-(2-...)
Affinity DataIC50:  2nMT: 2°CAssay Description:M2 anti-FLAG antibody coated 96-well plates were coated with recombinant FLAG-hMAdCAM-1 contained in Dulbecco PBS. The compounds to be tested were ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM16817((2S)-2-[(2,6-dichlorophenyl)formamido]-3-{4-[5-(2-...)
Affinity DataIC50:  2nMT: 2°CAssay Description:M2 anti-FLAG antibody coated 96-well plates were coated with recombinant FLAG-hMAdCAM-1 contained in Dulbecco PBS. The compounds to be tested were ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM16810((2S)-2-[(2,6-dichlorophenyl)formamido]-3-(4-{5-met...)
Affinity DataIC50:  2nMT: 2°CAssay Description:M2 anti-FLAG antibody coated 96-well plates were coated with recombinant FLAG-hMAdCAM-1 contained in Dulbecco PBS. The compounds to be tested were ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50108213((S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amin...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of integrin alpha4-beta7 of human RPMI-8866 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM314077(US9610264, Compound 11)
Affinity DataIC50:  2.19nMAssay Description:The studies began by screening for the optimal protein concentrations for the method. The studies were conducted in goat anti-mouse IgG coated black ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50144751((S)-2-({((S)-1-Benzenesulfonyl-azetidin-2-yl)-[(Z)...)
Affinity DataIC50:  2.20nMAssay Description:Inhibitory activity of compound against alpha4-beta7 integrin using MAdCAM-Ig ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM314078(US9610264, Compound 12)
Affinity DataIC50:  2.45nMAssay Description:The studies began by screening for the optimal protein concentrations for the method. The studies were conducted in goat anti-mouse IgG coated black ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50116289(2-[(1-Benzenesulfonyl-pyrrolidine-2-carbonyl)-amin...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of [125I]MAdCAM-Ig binding to human integrin alpha4-beta7 of RPMI-8866 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM314079(US9610264, Compound 14)
Affinity DataIC50:  2.64nMAssay Description:The studies began by screening for the optimal protein concentrations for the method. The studies were conducted in goat anti-mouse IgG coated black ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM314080(US9610264, Compound 13)
Affinity DataIC50:  2.80nMAssay Description:The studies began by screening for the optimal protein concentrations for the method. The studies were conducted in goat anti-mouse IgG coated black ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50108338(CHEMBL288474 | Pyrrolidine-1-carboxylic acid 4-{(S...)
Affinity DataIC50:  2.80nMAssay Description:Alpha4-beta7 integrin binding affinity was determined in duplicate by a radioligand binding assay using [125I]-VCAM-Ig and a suspension of RPMI-8866 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM16802((2S)-2-[(2,6-dichlorophenyl)formamido]-3-[4-(5-met...)
Affinity DataIC50:  3nMT: 2°CAssay Description:M2 anti-FLAG antibody coated 96-well plates were coated with recombinant FLAG-hMAdCAM-1 contained in Dulbecco PBS. The compounds to be tested were ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50105377((S)-2-{[(S)-1-(3,5-Dichloro-benzenesulfonyl)-2-met...)
Affinity DataIC50:  3nMAssay Description:Antagonistic activity against VLA-4 integrin of human jurkat cells using [125I]VCAM-Ig as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM16802((2S)-2-[(2,6-dichlorophenyl)formamido]-3-[4-(5-met...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50373006(CHEMBL273183)
Affinity DataIC50:  3nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM16816((2S)-2-[(2,6-dichlorophenyl)formamido]-3-{4-[2-met...)
Affinity DataIC50:  3nMT: 2°CAssay Description:M2 anti-FLAG antibody coated 96-well plates were coated with recombinant FLAG-hMAdCAM-1 contained in Dulbecco PBS. The compounds to be tested were ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM16818((2S)-2-[(2,6-dichlorophenyl)formamido]-3-(4-{2-met...)
Affinity DataIC50:  3nMT: 2°CAssay Description:M2 anti-FLAG antibody coated 96-well plates were coated with recombinant FLAG-hMAdCAM-1 contained in Dulbecco PBS. The compounds to be tested were ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50437674(CHEMBL2408066)
Affinity DataIC50:  3nMAssay Description:Inhibition of alpha4beta7 integrin-mediated human 8866 cell adhesion to MadCAM-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50144792((S)-2-(2,6-Dichloro-benzoylamino)-3-[2-(2,6-dichlo...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of Mn2+ activated state of alpha4-beta7 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50124258(2-{[1-((S)-Benzenesulfonyl)-cyclobutanecarbonyl]-a...)
Affinity DataIC50:  3.20nMAssay Description:Binding affinity towards VLA-4 (alpha4 beta7) receptor in human RPMI-8866 B-cell line using [125I]MAdCAM-Ig as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50108323(CHEMBL43213 | Morpholine-4-carboxylic acid 4-((S)-...)
Affinity DataIC50:  3.5nMAssay Description:Alpha4-beta7 integrin binding affinity was determined in duplicate by a radioligand binding assay using [125I]-VCAM-Ig and a suspension of RPMI-8866 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50116287((S)-2-{[(S)-1-(2-Cyano-phenyl)-pyrrolidine-2-carbo...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of [125I]MAdCAM-Ig binding to human integrin alpha4-beta7 of RPMI-8866 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50124290(3-(2'-Methoxy-biphenyl-4-yl)-2-{[1-((S)-1-methyl-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [125I]-VCAM-Ig binding to human integrin alpha4-beta7 receptor in RPMI-8866 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50373012(CHEMBL409728)
Affinity DataIC50:  4nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50437675(CHEMBL2408062)
Affinity DataIC50:  4nMAssay Description:Inhibition of alpha4beta7 integrin-mediated human 8866 cell adhesion to MadCAM-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50144755((2S)-2-[(Z)-{[(2S)-1-(benzenesulfonyl)azetidin-2-y...)
Affinity DataIC50:  4.10nMAssay Description:Inhibitory activity of compound against alpha4-beta7 integrin using MAdCAM-Ig ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50144791((S)-3-[2-(2,6-Dichloro-phenyl)-benzooxazol-5-yl]-2...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of Mn2+ activated state of alpha4-beta7 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50108343(CHEMBL43858 | Pyrrolidine-1-carboxylic acid 4-{(S)...)
Affinity DataIC50:  4.40nMAssay Description:Alpha4-beta7 integrin binding affinity was determined in duplicate by a radioligand binding assay using [125I]-VCAM-Ig and a suspension of RPMI-8866 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM314081(US9610264, Compound 15)
Affinity DataIC50:  4.67nMAssay Description:The studies began by screening for the optimal protein concentrations for the method. The studies were conducted in goat anti-mouse IgG coated black ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50124260(2-{[4-((S)-Benzenesulfonyl)-tetrahydro-thiopyran-4...)
Affinity DataIC50:  5nMAssay Description:Binding affinity towards VLA-4 (alpha4 beta7) receptor in human RPMI-8866 B-cell line using [125I]MAdCAM-Ig as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50373002(CHEMBL272966)
Affinity DataIC50:  5nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50116298(2-[(1-Benzenesulfonyl-cyclopentanecarbonyl)-amino]...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [125I]MAdCAM-Ig binding to human integrin alpha4-beta7 of RPMI-8866 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50124240(2-{[1-((S)-Benzenesulfonyl)-cyclopentanecarbonyl]-...)
Affinity DataIC50:  5nMAssay Description:Binding affinity towards VLA-4 (alpha4 beta7) receptor in human RPMI-8866 B-cell line using [125I]MAdCAM-Ig as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50124226(3-(2',6'-Dimethoxy-biphenyl-4-yl)-2-{[1-((S)-4-flu...)
Affinity DataIC50:  5nMAssay Description:Binding affinity towards VLA-4 (alpha4 beta7) receptor in human RPMI-8866 B-cell line using [125I]MAdCAM-Ig as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Kflp Biotech

US Patent
LigandPNGBDBM50124242(2-{[3-((S)-Benzenesulfonyl)-tetrahydro-furan-3-car...)
Affinity DataIC50:  5.20nMAssay Description:Binding affinity towards VLA-4 (alpha4 beta-1) receptor in human Jurkat cells using [125I]VCAM-Ig as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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