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Found 444 Enz. Inhib. hit(s) with Target = 'Heparanase'
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388329(CHEMBL2059500)
Affinity DataKi:  3.70nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388343(CHEMBL2059243)
Affinity DataKi:  5.5nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388341(CHEMBL2059241)
Affinity DataKi:  5.80nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388342(CHEMBL2059242)
Affinity DataKi:  6nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388331(CHEMBL2059499)
Affinity DataKi:  6.10nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388345(CHEMBL2059245)
Affinity DataKi:  6.40nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378647(CHEMBL1627122 | PI-88)
Affinity DataKi:  7.90nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388332(CHEMBL2059498)
Affinity DataKi:  8.40nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388346(CHEMBL2059246)
Affinity DataKi:  8.5nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388335(CHEMBL2059503)
Affinity DataKi:  9.10nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388336(CHEMBL2059504)
Affinity DataKi:  9.10nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388330(CHEMBL2059247)
Affinity DataKi:  10.5nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388328(CHEMBL2059505)
Affinity DataKi:  11.3nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388334(CHEMBL2059501)
Affinity DataKi:  16nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388333(CHEMBL2059502)
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388344(CHEMBL2059244)
Affinity DataKi:  22.3nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388340(CHEMBL2059510)
Affinity DataKi:  30nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388338(CHEMBL2059508)
Affinity DataKi:  111nMAssay Description:Inhibition of human recombinant heparanase after 2 to 24 hrs by WST1 dye based fondaparinux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50375292(CHEMBL407200)
Affinity DataKi:  200nMAssay Description:Inhibition of human platelet heparanase by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50375290(CHEMBL279625)
Affinity DataKi:  240nMAssay Description:Inhibition of human platelet heparanase by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50375291(CHEMBL439118)
Affinity DataKi:  280nMAssay Description:Inhibition of human platelet heparanase by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50375287(CHEMBL260220)
Affinity DataKi:  2.23E+3nMAssay Description:Inhibition of human platelet heparanase by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Mus musculus)
University Of Ferrara

Curated by ChEMBL
LigandPNGBDBM50179360(CHEMBL3040216)
Affinity DataKi:  4.80E+4nMAssay Description:Inhibition of mouse B16-BL6 cells derived heparanase using [3H]HS as substrate after 6 hrs by size exclusion chromatography based liquid scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50375287(CHEMBL260220)
Affinity DataKi:  6.83E+4nMAssay Description:Inhibition of human platelet heparanase by uncompetitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50466629(CHEMBL4280766)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant HPSE (unknown origin) using fondaparinux as substrate incubated for 3 hrs in absence of light by WST1 assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175932(1,3-bis-[4-(5,6-dimethyl-1H-benzoimidazol-2-yl)phe...)
Affinity DataIC50:  75nMAssay Description:Inhibitory activity against heparanase from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175932(1,3-bis-[4-(5,6-dimethyl-1H-benzoimidazol-2-yl)phe...)
Affinity DataIC50:  75nMAssay Description:Inhibition of recombinant heparanase catalytic stie (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50466636(CHEMBL4286441)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant HPSE (unknown origin) using fondaparinux as substrate incubated for 3 hrs in absence of light by WST1 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50431662(CHEMBL2349246)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant heparanase catalytic stie (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175936(1,3-bis(4-(6-methyl-1H-benzo[d]imidazol-2-yl)pheny...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against heparanase from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175938(1,3-bis(4-(7-methyl-1H-benzo[d]imidazol-2-yl)pheny...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against heparanase from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175931(1-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-3-(4-(7-met...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against heparanase from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50506597(CHEMBL4576477)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant HPSE GS3 (unknown origin) using fondaparinux as substrate incubated for 3 hrs in absence of light by WST1 based colorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50466651(CHEMBL4283251)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant HPSE (unknown origin) using fondaparinux as substrate incubated for 3 hrs in absence of light by WST1 assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50165669((2-{4-[2-(3-Bromo-phenylcarbamoyl)-vinyl]-2-fluoro...)
Affinity DataIC50:  200nMAssay Description:Inhibition of heparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50165660(2-(3-(5-(4-chlorophenyl)benzo[d]oxazol-2-yl)-4-(pr...)
Affinity DataIC50:  200nMAssay Description:Inhibition of heparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50165653((2-{4-[2-(3,4-Dichloro-phenylcarbamoyl)-vinyl]-2-f...)
Affinity DataIC50:  200nMAssay Description:Inhibition of heparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147546(2-(3-(5-(benzo[d][1,3]dioxol-5-yl)benzo[d]oxazol-2...)
Affinity DataIC50:  200nMAssay Description:Inhibition of heparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147546(2-(3-(5-(benzo[d][1,3]dioxol-5-yl)benzo[d]oxazol-2...)
Affinity DataIC50:  200nMAssay Description:In vivo inhibitory activity against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50147513(2-[3-[5-(4-Chloro-phenyl)-benzooxazol-2-yl]-4-(2-m...)
Affinity DataIC50:  200nMAssay Description:In vivo inhibitory activity against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50165639((2-{4-[2-(2,4-Dichloro-phenylcarbamoyl)-vinyl]-2-f...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50165660(2-(3-(5-(4-chlorophenyl)benzo[d]oxazol-2-yl)-4-(pr...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50165653((2-{4-[2-(3,4-Dichloro-phenylcarbamoyl)-vinyl]-2-f...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50165669((2-{4-[2-(3-Bromo-phenylcarbamoyl)-vinyl]-2-fluoro...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibitory concentration against human HeparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50431663(CHEMBL2349247)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant heparanase catalytic stie (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50165660(2-(3-(5-(4-chlorophenyl)benzo[d]oxazol-2-yl)-4-(pr...)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant heparanase catalytic stie (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50165639((2-{4-[2-(2,4-Dichloro-phenylcarbamoyl)-vinyl]-2-f...)
Affinity DataIC50:  200nMAssay Description:Inhibition of heparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175811(CHEMBL200215 | N-(4-{[4-(1H-benzoimidazol-2-yl)phe...)
Affinity DataIC50:  230nMAssay Description:Inhibitory activity against heparanase from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175811(CHEMBL200215 | N-(4-{[4-(1H-benzoimidazol-2-yl)phe...)
Affinity DataIC50:  230nMAssay Description:Inhibition of recombinant heparanase catalytic stie (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeparanase(Homo sapiens (Human))
Progen Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50375289(CHEMBL258980)
Affinity DataIC50:  250nMAssay Description:Inhibition of human platelet heparanaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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