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Found 57 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 3A4/3A5'
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using Midazolam as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490735(CHEMBL1863002 | DNDI1449875)
Affinity DataIC50:  300nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50014757((4-Chloro-phenyl)-(2-chloro-phenyl)-pyridin-3-yl-m...)
Affinity DataIC50:  600nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490750(CHEMBL2334336)
Affinity DataIC50:  600nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490748(CHEMBL1863056 | DNDI1435775)
Affinity DataIC50:  810nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485474(CHEMBL1862838 | DNDI1322027)
Affinity DataIC50:  900nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490744(CHEMBL1862905 | DNDI1467768)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490737(CHEMBL1863288 | DNDI1538112)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485473(CHEMBL1863499 | DNDI1336037)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490736(CHEMBL1863145 | DNDI1343536)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485466(CHEMBL1863004 | DNDI1335913)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485471(CHEMBL1863383 | DNDI1335912)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490742(CHEMBL1863462 | DNDI1460901)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485476(CHEMBL1863160 | DNDI1294211)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490743(CHEMBL1863046 | DNDI1434940)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490749(CHEMBL1862798 | DNDI1434923)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490753(CHEMBL1863455 | DNDI1465083)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485475(CHEMBL1863146 | DNDI1336031)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490741(CHEMBL2334337)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490751(CHEMBL1863306 | DNDI1434944)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490745(CHEMBL1863273 | DNDI1338491)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490746(CHEMBL1863393 | DNDI1388149)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490752(CHEMBL1862941 | DNDI1551253)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485468(CHEMBL1863039 | DNDI1467766)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485467(CHEMBL1863325 | DNDI1574842)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485470(CHEMBL1863007 | DNDI1342987)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485469(CHEMBL1863183 | DNDI1268111)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using testosterone as substrate preincubated for 30 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490738(CHEMBL1863131 | DNDI1490391)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490747(CHEMBL1863090 | DNDI1449876)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490740(CHEMBL1862938 | DNDI1467767)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490739(CHEMBL1862975 | DNDI1335908)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50485472(CHEMBL1863379 | DNDI1330083)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using testosterone as substrate measured for 10 to 30 mins in presence of NADPH regenerating system ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate measured for 10 to 30 mins in presence of NADPH regenerating system by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using testosterone as substrate preincubated for 30 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50490734(CHEMBL1863136 | DNDI1402165)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50305083(3-((3S,6S)-6-Isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,...)
Affinity DataIC50: >3.00E+4nMpH: 7.4 T: 2°CAssay Description:Human liver microsomes (HLMs) (0.3 mg/mL in 0.1-M potassium phosphate buffer, pH 7.4) are incubated with CYP (cytochromes P450) isozyme-selective sub...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM106203(US9695174, I-1)
Affinity DataIC50: >3.00E+4nMpH: 7.4 T: 2°CAssay Description:Human liver microsomes (HLMs) (0.3 mg/mL in 0.1-M potassium phosphate buffer, pH 7.4) are incubated with CYP (cytochromes P450) isozyme-selective sub...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM276748(US10071992, Example 3.5 | US10071992, Example 5 | ...)
Affinity DataIC50: >3.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in pooled human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50491627(CHEMBL2386145)
Affinity DataIC50: >5.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50491622(CHEMBL2386156)
Affinity DataIC50: >5.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50491626(CHEMBL2386155)
Affinity DataIC50: >5.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50568682(CHEMBL4861470)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using Midazolam as substrate measured after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50272591(CHEMBL4128835)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4/5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50491620(CHEMBL2386141)
Affinity DataIC50: >5.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50491624(CHEMBL2386149)
Affinity DataIC50: >5.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4/3A5(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50491623(CHEMBL2386150)
Affinity DataIC50: >5.00E+4nMAssay Description:Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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