BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 847305 CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(Br)cc(NC(C)C)c1C InChI=1S/C21H28BrN3O2/c1-6-7-15-8-13(4)25-21(27)18(15)11-23-20(26)17-9-16(22)10-19(14(17)5)24-12(2)3/h8-10,12,24H,6-7,11H2,1-5H3,(H,23,26)(H,25,27) GSLUZKJWVUIMTB-UHFFFAOYSA-N 420308 5-Bromo-2-methyl-3-[(1-methylethyl)amino]-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]benzamide::US10478426, Example 1 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 501 US Patent 10.7270/Q2M61NMK aid1803990 US10478426 Burgess, JL; Knight, SD GLAXOSMITHKLINE LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420308&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 847306 CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc(NC(C)C)c1C)-c1ccc(nc1)N1CCN(C)CC1 InChI=1S/C31H42N6O2/c1-7-8-23-15-21(4)35-31(39)27(23)19-33-30(38)26-16-25(17-28(22(26)5)34-20(2)3)24-9-10-29(32-18-24)37-13-11-36(6)12-14-37/h9-10,15-18,20,34H,7-8,11-14,19H2,1-6H3,(H,33,38)(H,35,39) BUADPKQHLDXMLK-UHFFFAOYSA-N 420310 2-Methyl-3-[(1-methylethyl)amino]-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-5-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]benzamide::US10478426, Example 2 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 40.0 US Patent 10.7270/Q2M61NMK aid1803990 US10478426 Burgess, JL; Knight, SD GLAXOSMITHKLINE LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420310&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 847307 CC(C)Nc1cc(Br)cc(C(=O)NCc2c(Cc3ccccc3)cc(C)[nH]c2=O)c1C InChI=1S/C25H28BrN3O2/c1-15(2)28-23-13-20(26)12-21(17(23)4)24(30)27-14-22-19(10-16(3)29-25(22)31)11-18-8-6-5-7-9-18/h5-10,12-13,15,28H,11,14H2,1-4H3,(H,27,30)(H,29,31) SNUWAWGCYPMRAZ-UHFFFAOYSA-N 420312 5-Bromo-2-methyl-3-[(1-methylethyl)amino]-N-{[6-methyl-2-oxo-4-(phenylmethyl)-1,2-dihydro-3-pyridinyl]methyl}benzamide::US10478426, Example 4 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 50.0 US Patent 10.7270/Q2M61NMK aid1803990 US10478426 Burgess, JL; Knight, SD GLAXOSMITHKLINE LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420312&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 847308 CC(C)Oc1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1Cl InChI=1S/C18H20Cl2N2O3/c1-9(2)25-15-7-12(19)6-13(16(15)20)17(23)21-8-14-10(3)5-11(4)22-18(14)24/h5-7,9H,8H2,1-4H3,(H,21,23)(H,22,24) BQIRDGDOTJKBAB-UHFFFAOYSA-N 420316 2,5-Dichloro-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-[(1-methylethyl)oxy]benzamide::US10478426, Example 24 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 250 US Patent 10.7270/Q2M61NMK aid1803990 US10478426 Burgess, JL; Knight, SD GLAXOSMITHKLINE LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420316&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 847309 CCC(C)Oc1cc(Br)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C 420317 5-Bromo-3-(sec-butoxy)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide::US10478426, Example 20::US10478426, Example 44 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 13.0 US Patent 10.7270/Q2M61NMK aid1803990 US10478426 Burgess, JL; Knight, SD GLAXOSMITHKLINE LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420317&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 847310 CC(CO)Nc1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C 420319 5—Chloro-N-[(4,6-dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-[(2-hydroxy-1-methylethyl)amino]-2-methylbenzamide::US10478426, Example 26 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 1000 US Patent 10.7270/Q2M61NMK aid1803990 US10478426 Burgess, JL; Knight, SD GLAXOSMITHKLINE LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420319&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 847311 COc1cccc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C InChI=1S/C17H20N2O3/c1-10-8-11(2)19-17(21)14(10)9-18-16(20)13-6-5-7-15(22-4)12(13)3/h5-8H,9H2,1-4H3,(H,18,20)(H,19,21) PJZRSEKWQPTNFO-UHFFFAOYSA-N 50193711 CHEMBL3955846::US10478426, Example 36 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 2500 US Patent 10.7270/Q2M61NMK aid1803990 US10478426 Burgess, JL; Knight, SD GLAXOSMITHKLINE LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193711&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 118046535 375076318 CHEMBL3955846 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 847312 CCC(C)Oc1cc(Br)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C 420317 5-Bromo-3-(sec-butoxy)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methylbenzamide::US10478426, Example 20::US10478426, Example 44 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 316 US Patent 10.7270/Q2M61NMK aid1803990 US10478426 Burgess, JL; Knight, SD GLAXOSMITHKLINE LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420317&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221433 Cc1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C(O)=O)n(C)n1 InChI=1S/C21H19FN6O3/c1-11-7-17(27(2)26-11)14-9-24-21(28-10-16(20(29)30)25-19(14)28)23-8-13-12-5-6-31-18(12)4-3-15(13)22/h3-4,7,9-10H,5-6,8H2,1-2H3,(H,23,24)(H,29,30) BBUIUQSZWUHXOF-UHFFFAOYSA-N 513638 8-(1,3-dimethyl-1H-pyrazol-5-yl)-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,2-c]pyrimidine-2-carboxylic acid::US11091495, Example 1::US11220509, Example 11::US11485738, Example 1 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513638&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676956 459630872 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221434 Cc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C(O)=O InChI=1S/C22H18FN5O3/c1-12-13(3-2-7-24-12)16-10-26-22(28-11-18(21(29)30)27-20(16)28)25-9-15-14-6-8-31-19(14)5-4-17(15)23/h2-5,7,10-11H,6,8-9H2,1H3,(H,25,26)(H,29,30) GUAVZVKIUUHFGS-UHFFFAOYSA-N 513639 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(2-methylpyridin-3-yl)imidazo[1,2-c]pyrimidine-2-carboxylic acid::US11091495, Example 2::US11485738, Example 2 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513639&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139381716 459630873 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221435 Cc1ncccc1-c1cnc(NCc2c(F)ccc3occc23)n2cc(nc12)C(O)=O InChI=1S/C22H16FN5O3/c1-12-13(3-2-7-24-12)16-10-26-22(28-11-18(21(29)30)27-20(16)28)25-9-15-14-6-8-31-19(14)5-4-17(15)23/h2-8,10-11H,9H2,1H3,(H,25,26)(H,29,30) SSPXUFXDBGMUJX-UHFFFAOYSA-N 513640 5-(((5-fluorobenzofuran-4-yl)methyl)amino)-8-(2-methylpyridin-3-yl)imidazo[1,2-c]pyrimidine-2-carboxylic acid::US11091495, Example 3::US11220509, Example 12::US11485738, Example 3 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513640&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139381724 459630874 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221436 Cc1cn(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C(O)=O InChI=1S/C20H17FN6O3/c1-11-8-26(10-24-11)16-7-23-20(27-9-15(19(28)29)25-18(16)27)22-6-13-12-4-5-30-17(12)3-2-14(13)21/h2-3,7-10H,4-6H2,1H3,(H,22,23)(H,28,29) IWOYVLMCYDRTSZ-UHFFFAOYSA-N 513641 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(4-methyl-1H-imidazol-1-yl)imidazo[1,2-c]pyrimidine-2-carboxylic acid::US11091495, Example 4::US11485738, Example 4 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513641&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139371731 459630875 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221437 CC(C)n1cc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C(O)=O InChI=1S/C23H23FN6O3/c1-12(2)30-10-17(13(3)28-30)16-9-26-23(29-11-19(22(31)32)27-21(16)29)25-8-15-14-6-7-33-20(14)5-4-18(15)24/h4-5,9-12H,6-8H2,1-3H3,(H,25,26)(H,31,32) FFGXAZIAUUNVRQ-UHFFFAOYSA-N 513642 US11091495, Example 5::US11220509, Example 5::US11485738, Example 5 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513642&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787997 459630876 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221438 COc1cc(C)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C(O)=O InChI=1S/C23H20FN5O4/c1-12-7-20(32-2)25-8-14(12)16-10-27-23(29-11-18(22(30)31)28-21(16)29)26-9-15-13-5-6-33-19(13)4-3-17(15)24/h3-4,7-8,10-11H,5-6,9H2,1-2H3,(H,26,27)(H,30,31) FHBLZWLFAFLEQB-UHFFFAOYSA-N 513643 US11091495, Example 6::US11220509, Example 6::US11485738, Example 14 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513643&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788051 459630877 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221439 Cc1nc(ncc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C(O)=O)C1CC1 InChI=1S/C24H21FN6O3/c1-12-15(8-26-21(29-12)13-2-3-13)17-10-28-24(31-11-19(23(32)33)30-22(17)31)27-9-16-14-6-7-34-20(14)5-4-18(16)25/h4-5,8,10-11,13H,2-3,6-7,9H2,1H3,(H,27,28)(H,32,33) YWZARKUVOPOHRP-UHFFFAOYSA-N 513645 US11091495, Example 7::US11220509, Example 7::US11485738, Example 7 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513645&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788158 459630879 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221440 CC(C)n1ncc(c1C)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C(O)=O InChI=1S/C23H23FN6O3/c1-12(2)30-13(3)15(10-27-30)17-9-26-23(29-11-19(22(31)32)28-21(17)29)25-8-16-14-6-7-33-20(14)5-4-18(16)24/h4-5,9-12H,6-8H2,1-3H3,(H,25,26)(H,31,32) PHXVDWPQFZOJHY-UHFFFAOYSA-N 513646 US11091495, Example 8::US11220509, Example 8::US11485738, Example 8 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513646&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788169 459630880 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221441 Cc1cc(-c2cnc(NCc3c(F)ccc4occc34)n3cc(nc23)C(O)=O)n(C)n1 InChI=1S/C21H17FN6O3/c1-11-7-17(27(2)26-11)14-9-24-21(28-10-16(20(29)30)25-19(14)28)23-8-13-12-5-6-31-18(12)4-3-15(13)22/h3-7,9-10H,8H2,1-2H3,(H,23,24)(H,29,30) KFNFZDYVLRPZEK-UHFFFAOYSA-N 513647 US11091495, Example 9::US11220509, Example 9::US11485738, Example 18 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513647&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788174 459630881 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221442 Cc1cc(-c2cnc(NCc3cccc4OCCc34)n3cc(nc23)C(O)=O)n(C)n1 InChI=1S/C21H20N6O3/c1-12-8-17(26(2)25-12)15-10-23-21(27-11-16(20(28)29)24-19(15)27)22-9-13-4-3-5-18-14(13)6-7-30-18/h3-5,8,10-11H,6-7,9H2,1-2H3,(H,22,23)(H,28,29) FPURDCYUVYLRQH-UHFFFAOYSA-N 513648 US11091495, Example 10::US11220509, Example 10::US11485738, Example 10 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513648&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788023 459630882 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221443 Cc1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C(N)=O)n(C)n1 InChI=1S/C21H20FN7O2/c1-11-7-17(28(2)27-11)14-9-25-21(29-10-16(19(23)30)26-20(14)29)24-8-13-12-5-6-31-18(12)4-3-15(13)22/h3-4,7,9-10H,5-6,8H2,1-2H3,(H2,23,30)(H,24,25) SQUISAAFYLZEJH-UHFFFAOYSA-N 513649 8-(1,3-dimethyl-1H-pyrazol-5-yl)-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,2-c]pyrimidine-2-carboxamide::US11091495, Example 11::US11485738, Example 11 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513649&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 151891326 459630883 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221444 Cc1ncccc1-c1cnc(NCc2c(F)ccc3occc23)n2cc(nc12)C(N)=O InChI=1S/C22H17FN6O2/c1-12-13(3-2-7-25-12)16-10-27-22(29-11-18(20(24)30)28-21(16)29)26-9-15-14-6-8-31-19(14)5-4-17(15)23/h2-8,10-11H,9H2,1H3,(H2,24,30)(H,26,27) SMHLMPSZVTVQDP-UHFFFAOYSA-N 513650 5-(((5-fluorobenzofuran-4-yl)methyl)amino)-8-(2-methylpyridin-3-yl)imidazo[1,2-c]pyrimidine-2-carboxamide::US11091495, Example 12::US11091495, Example 22::US11220509, Example 22::US11485738, Example 12 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513650&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139381725 459630884 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221445 CC(C)n1cc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C(N)=O InChI=1S/C23H24FN7O2/c1-12(2)31-10-17(13(3)29-31)16-9-27-23(30-11-19(21(25)32)28-22(16)30)26-8-15-14-6-7-33-20(14)5-4-18(15)24/h4-5,9-12H,6-8H2,1-3H3,(H2,25,32)(H,26,27) GFMLNRBXDJUWAC-UHFFFAOYSA-N 513651 US11091495, Example 13::US11091495, Example 23::US11220509, Example 13::US11485738, Example 13 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513651&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676991 459630885 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221446 COc1cc(C)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C(O)=O InChI=1S/C23H20FN5O4/c1-12-7-20(32-2)25-8-14(12)16-10-27-23(29-11-18(22(30)31)28-21(16)29)26-9-15-13-5-6-33-19(13)4-3-17(15)24/h3-4,7-8,10-11H,5-6,9H2,1-2H3,(H,26,27)(H,30,31) FHBLZWLFAFLEQB-UHFFFAOYSA-N 513643 US11091495, Example 6::US11220509, Example 6::US11485738, Example 14 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513643&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788051 459630877 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221447 Cc1nc(ncc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C(N)=O)C1CC1 InChI=1S/C24H22FN7O2/c1-12-15(8-27-22(30-12)13-2-3-13)17-10-29-24(32-11-19(21(26)33)31-23(17)32)28-9-16-14-6-7-34-20(14)5-4-18(16)25/h4-5,8,10-11,13H,2-3,6-7,9H2,1H3,(H2,26,33)(H,28,29) DNWQZLJLDRUAIN-UHFFFAOYSA-N 513653 US11091495, Example 15::US11220509, Example 15::US11485738, Example 15 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513653&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788178 459630887 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221448 CC(C)n1ncc(c1C)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C(N)=O InChI=1S/C23H24FN7O2/c1-12(2)31-13(3)15(10-28-31)17-9-27-23(30-11-19(21(25)32)29-22(17)30)26-8-16-14-6-7-33-20(14)5-4-18(16)24/h4-5,9-12H,6-8H2,1-3H3,(H2,25,32)(H,26,27) QUZHMSFJDYPQHN-UHFFFAOYSA-N 513654 US11091495, Example 16::US11220509, Example 16::US11485738, Example 16 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513654&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787998 459630888 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221449 Cc1cn(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C(N)=O InChI=1S/C20H18FN7O2/c1-11-8-27(10-25-11)16-7-24-20(28-9-15(18(22)29)26-19(16)28)23-6-13-12-4-5-30-17(12)3-2-14(13)21/h2-3,7-10H,4-6H2,1H3,(H2,22,29)(H,23,24) WEZXQKRCSWEEJV-UHFFFAOYSA-N 513655 US11091495, Example 17::US11220509, Example 17::US11485738, Example 17 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513655&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788001 459630889 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221450 Cc1cc(-c2cnc(NCc3c(F)ccc4occc34)n3cc(nc23)C(O)=O)n(C)n1 InChI=1S/C21H17FN6O3/c1-11-7-17(27(2)26-11)14-9-24-21(28-10-16(20(29)30)25-19(14)28)23-8-13-12-5-6-31-18(12)4-3-15(13)22/h3-7,9-10H,8H2,1-2H3,(H,23,24)(H,29,30) KFNFZDYVLRPZEK-UHFFFAOYSA-N 513647 US11091495, Example 9::US11220509, Example 9::US11485738, Example 18 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513647&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788174 459630881 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221451 Cc1cc(-c2cnc(NCc3cccc4OCCc34)n3cc(nc23)C(N)=O)n(C)n1 InChI=1S/C21H21N7O2/c1-12-8-17(27(2)26-12)15-10-24-21(28-11-16(19(22)29)25-20(15)28)23-9-13-4-3-5-18-14(13)6-7-30-18/h3-5,8,10-11H,6-7,9H2,1-2H3,(H2,22,29)(H,23,24) UVKFNNHKXWKUBX-UHFFFAOYSA-N 513657 US11091495, Example 19::US11220509, Example 19::US11485738, Example 19 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513657&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787970 459630891 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221452 CNC(=O)c1cn2c(NCc3c4CCOc4ccc3F)ncc(-c3cc(C)nn3C)c2n1 InChI=1S/C22H22FN7O2/c1-12-8-18(29(3)28-12)15-10-26-22(30-11-17(21(31)24-2)27-20(15)30)25-9-14-13-6-7-32-19(13)5-4-16(14)23/h4-5,8,10-11H,6-7,9H2,1-3H3,(H,24,31)(H,25,26) CELMXBCHNYHKML-UHFFFAOYSA-N 513658 US11091495, Example 20::US11220509, Example 20::US11485738, Example 20 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513658&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788056 459630892 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221453 CN(C)C(=O)c1cn2c(NCc3c4CCOc4ccc3F)ncc(-c3cc(C)nn3C)c2n1 InChI=1S/C23H24FN7O2/c1-13-9-19(30(4)28-13)16-11-26-23(31-12-18(27-21(16)31)22(32)29(2)3)25-10-15-14-7-8-33-20(14)6-5-17(15)24/h5-6,9,11-12H,7-8,10H2,1-4H3,(H,25,26) HXSVXZFLCYWQIO-UHFFFAOYSA-N 513659 US11091495, Example 21::US11220509, Example 21::US11485738, Example 21 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 >500 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513659&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787982 459630893 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221454 Cc1ncccc1-c1cnc(NCc2c(F)ccc3occc23)n2cc(nc12)C#N InChI=1S/C22H15FN6O/c1-13-15(3-2-7-25-13)18-11-27-22(29-12-14(9-24)28-21(18)29)26-10-17-16-6-8-30-20(16)5-4-19(17)23/h2-8,11-12H,10H2,1H3,(H,26,27) QRQXMDNBSDFOPU-UHFFFAOYSA-N 580138 5-(((5-fluorobenzofuran-4-yl)methyl)amino)-8-(2-methylpyridin-3-yl)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11485738, Example 22 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580138&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676961 475725994 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221455 CC(C)n1cc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H22FN7O/c1-13(2)31-12-19(14(3)29-31)18-10-27-23(30-11-15(8-25)28-22(18)30)26-9-17-16-6-7-32-21(16)5-4-20(17)24/h4-5,10-13H,6-7,9H2,1-3H3,(H,26,27) ZDBPLSPFJZAYOW-UHFFFAOYSA-N 580139 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(1-isopropyl-3-methyl-1H-pyrazol-4-yl)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11485738, Example 23 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580139&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139371257 475725995 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221456 COc1cc(C)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H19FN6O2/c1-13-7-21(31-2)26-9-16(13)18-11-28-23(30-12-14(8-25)29-22(18)30)27-10-17-15-5-6-32-20(15)4-3-19(17)24/h3-4,7,9,11-12H,5-6,10H2,1-2H3,(H,27,28) KGIVHVXEOZCXFH-UHFFFAOYSA-N 513663 US11091495, Example 24::US11220509, Example 24::US11485738, Example 24 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513663&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788151 459630895 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221457 Cc1nc(ncc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N)C1CC1 InChI=1S/C24H20FN7O/c1-13-17(9-27-22(30-13)14-2-3-14)19-11-29-24(32-12-15(8-26)31-23(19)32)28-10-18-16-6-7-33-21(16)5-4-20(18)25/h4-5,9,11-12,14H,2-3,6-7,10H2,1H3,(H,28,29) YQGZSHFBWVKMJT-UHFFFAOYSA-N 513664 US11091495, Example 25::US11220509, Example 25::US11485738, Example 25 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513664&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788100 459630896 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221458 CC(C)n1ncc(c1C)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H22FN7O/c1-13(2)31-14(3)17(11-28-31)19-10-27-23(30-12-15(8-25)29-22(19)30)26-9-18-16-6-7-32-21(16)5-4-20(18)24/h4-5,10-13H,6-7,9H2,1-3H3,(H,26,27) PHDFFMXSXCLBRI-UHFFFAOYSA-N 513665 US11091495, Example 26::US11220509, Example 26::US11485738, Example 26 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513665&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788097 459630897 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221459 Cc1cc(-c2cnc(NCc3cccc4OCOc34)n3cc(nc23)C#N)n(C)n1 InChI=1S/C20H17N7O2/c1-12-6-16(26(2)25-12)15-9-23-20(27-10-14(7-21)24-19(15)27)22-8-13-4-3-5-17-18(13)29-11-28-17/h3-6,9-10H,8,11H2,1-2H3,(H,22,23) MWBYFOVSPVFUMG-UHFFFAOYSA-N 513666 US11091495, Example 27::US11220509, Example 27::US11485738, Example 27 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 >500 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513666&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788170 459630898 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221460 Cc1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C#N)n(C)n1 InChI=1S/C21H18FN7O/c1-12-7-18(28(2)27-12)16-10-25-21(29-11-13(8-23)26-20(16)29)24-9-15-14-5-6-30-19(14)4-3-17(15)22/h3-4,7,10-11H,5-6,9H2,1-2H3,(H,24,25) WUFADHRATSOXBZ-UHFFFAOYSA-N 513667 US11091495, Example 169::US11091495, Example 228::US11091495, Example 28::US11091495, Example 78::US11091495, Example 86::US11220509, Example 169::US11485738, Example 86 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513667&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 9L0 7SI5 152324986 459630899 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221461 Cc1cc(-c2cnc(NCc3c4CCOc4ccc3Cl)n3cc(nc23)C#N)n(C)n1 InChI=1S/C21H18ClN7O/c1-12-7-18(28(2)27-12)16-10-25-21(29-11-13(8-23)26-20(16)29)24-9-15-14-5-6-30-19(14)4-3-17(15)22/h3-4,7,10-11H,5-6,9H2,1-2H3,(H,24,25) NLRGHQHTQSTZQE-UHFFFAOYSA-N 513668 US11091495, Example 29::US11220509, Example 29::US11485738, Example 29 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 >500 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513668&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787985 459630900 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221462 Cc1cc(-c2cnc(NCc3cccc4OCCc34)n3cc(nc23)C#N)n(C)n1 InChI=1S/C21H19N7O/c1-13-8-18(27(2)26-13)17-11-24-21(28-12-15(9-22)25-20(17)28)23-10-14-4-3-5-19-16(14)6-7-29-19/h3-5,8,11-12H,6-7,10H2,1-2H3,(H,23,24) LXVOSFCMKWIQOD-UHFFFAOYSA-N 513669 US11091495, Example 30::US11220509, Example 30::US11485738, Example 30 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513669&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788072 459630901 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221463 CN(C)C(=O)c1ccc(c(Cl)c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H20ClFN6O2/c1-32(2)24(34)14-3-4-16(20(26)9-14)19-12-30-25(33-13-15(10-28)31-23(19)33)29-11-18-17-7-8-35-22(17)6-5-21(18)27/h3-6,9,12-13H,7-8,11H2,1-2H3,(H,29,30) BZZOBNQFAQADBL-UHFFFAOYSA-N 513670 US11091495, Example 31::US11220509, Example 31::US11485738, Example 31 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513670&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788180 459630902 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221464 CN(C)Cc1ccc(c(C)c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H25FN6O/c1-16-10-17(14-32(2)3)4-5-19(16)22-13-30-26(33-15-18(11-28)31-25(22)33)29-12-21-20-8-9-34-24(20)7-6-23(21)27/h4-7,10,13,15H,8-9,12,14H2,1-3H3,(H,29,30) FLCIOLFIDGTRCI-UHFFFAOYSA-N 513671 US11091495, Example 173::US11091495, Example 202::US11091495, Example 223::US11091495, Example 32::US11220509, Example 223::US11485738, Example 223 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513671&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 9JL 7SI4 155788096 459630903 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221465 CN(C)Cc1ccc(c(Cl)c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H22ClFN6O/c1-32(2)13-15-3-4-17(21(26)9-15)20-12-30-25(33-14-16(10-28)31-24(20)33)29-11-19-18-7-8-34-23(18)6-5-22(19)27/h3-6,9,12,14H,7-8,11,13H2,1-2H3,(H,29,30) RGZMOVDUMVFHTI-UHFFFAOYSA-N 513672 US11091495, Example 33::US11220509, Example 33::US11485738, Example 33 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513672&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787980 459630904 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221466 CN(C)C(=O)c1ccc(c(Cl)c1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H19ClF2N6O2/c1-33(2)24(35)16-4-3-15(21(26)22(16)28)18-11-31-25(34-12-13(9-29)32-23(18)34)30-10-17-14-7-8-36-20(14)6-5-19(17)27/h3-6,11-12H,7-8,10H2,1-2H3,(H,30,31) PPHWYWUAXCJQJC-UHFFFAOYSA-N 513673 US11091495, Example 34::US11220509, Example 34::US11485738, Example 34 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513673&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788187 459630905 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221467 CN(C)C(=O)c1cc(Cl)c(cc1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H19ClF2N6O2/c1-33(2)24(35)16-7-19(26)15(8-21(16)28)18-11-31-25(34-12-13(9-29)32-23(18)34)30-10-17-14-5-6-36-22(14)4-3-20(17)27/h3-4,7-8,11-12H,5-6,10H2,1-2H3,(H,30,31) RQYHUMZYHCVXCP-UHFFFAOYSA-N 513674 US11091495, Example 35::US11220509, Example 35::US11485738, Example 35 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513674&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788109 459630906 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221468 CN(C)C(=O)c1ccc(cc1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H20F2N6O2/c1-32(2)24(34)17-4-3-14(9-21(17)27)18-11-29-25(33-13-15(10-28)31-23(18)33)30-12-19-16-7-8-35-22(16)6-5-20(19)26/h3-6,9,11,13H,7-8,12H2,1-2H3,(H,29,30) ZDIVVSQBMFUVPR-UHFFFAOYSA-N 513675 US11091495, Example 36::US11220509, Example 36::US11485738, Example 36 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513675&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788182 459630907 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221469 CN(C)Cc1ccc(c(F)c1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H21F3N6O/c1-33(2)12-14-3-4-17(23(28)22(14)27)19-11-31-25(34-13-15(9-29)32-24(19)34)30-10-18-16-7-8-35-21(16)6-5-20(18)26/h3-6,11,13H,7-8,10,12H2,1-2H3,(H,30,31) FBQCLUFNLZGWFS-UHFFFAOYSA-N 513676 US11091495, Example 37::US11220509, Example 37::US11485738, Example 37 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513676&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788083 459630908 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221470 CN(C)C(=O)c1cc(F)c(cc1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H19F3N6O2/c1-33(2)24(35)16-8-20(27)15(7-21(16)28)18-11-31-25(34-12-13(9-29)32-23(18)34)30-10-17-14-5-6-36-22(14)4-3-19(17)26/h3-4,7-8,11-12H,5-6,10H2,1-2H3,(H,30,31) WTANIBLXUWSPSF-UHFFFAOYSA-N 513677 US11091495, Example 38::US11220509, Example 38::US11485738, Example 38 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513677&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788080 459630909 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221471 CN(C)Cc1cc(F)c(cc1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H21F3N6O/c1-33(2)12-14-7-22(28)17(8-21(14)27)19-11-31-25(34-13-15(9-29)32-24(19)34)30-10-18-16-5-6-35-23(16)4-3-20(18)26/h3-4,7-8,11,13H,5-6,10,12H2,1-2H3,(H,30,31) VHOOQQHNKBRMPQ-UHFFFAOYSA-N 513678 US11091495, Example 39::US11220509, Example 39::US11485738, Example 39 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513678&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788141 459630910 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221472 CN(C)Cc1ncc(cc1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C24H21F2N7O/c1-32(2)13-21-20(26)7-14(9-28-21)17-10-29-24(33-12-15(8-27)31-23(17)33)30-11-18-16-5-6-34-22(16)4-3-19(18)25/h3-4,7,9-10,12H,5-6,11,13H2,1-2H3,(H,29,30) NYZOHWLREJEJPH-UHFFFAOYSA-N 513679 US11091495, Example 40::US11220509, Example 40::US11485738, Example 40 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513679&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788070 459630911 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221473 Cc1cc(cnn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C21H16FN7O/c1-12-6-13(8-26-28-12)16-9-24-21(29-11-14(7-23)27-20(16)29)25-10-17-15-4-5-30-19(15)3-2-18(17)22/h2-3,6,8-9,11H,4-5,10H2,1H3,(H,24,25) GFEAHOVOZGDKPN-UHFFFAOYSA-N 513680 US11091495, Example 41::US11220509, Example 41::US11485738, Example 41 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513680&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788017 459630912 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221474 CN(C)C(=O)c1ccc(c(F)c1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H19F3N6O2/c1-33(2)24(35)16-4-3-15(21(27)22(16)28)18-11-31-25(34-12-13(9-29)32-23(18)34)30-10-17-14-7-8-36-20(14)6-5-19(17)26/h3-6,11-12H,7-8,10H2,1-2H3,(H,30,31) RGJMRCLTWJSRTM-UHFFFAOYSA-N 513681 US11091495, Example 42::US11220509, Example 42::US11485738, Example 42 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513681&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788185 459630913 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221475 CN(C)C(=O)c1cc(C)c(cc1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H22F2N6O2/c1-14-8-18(25(35)33(2)3)22(28)9-17(14)20-12-31-26(34-13-15(10-29)32-24(20)34)30-11-19-16-6-7-36-23(16)5-4-21(19)27/h4-5,8-9,12-13H,6-7,11H2,1-3H3,(H,30,31) YMUFEFMSYPTSRF-UHFFFAOYSA-N 513682 US11091495, Example 43::US11220509, Example 43::US11485738, Example 43 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513682&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787971 459630914 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221476 CN(C)C(=O)c1ccc(c(C)c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H23FN6O2/c1-15-10-16(25(34)32(2)3)4-5-18(15)21-13-30-26(33-14-17(11-28)31-24(21)33)29-12-20-19-8-9-35-23(19)7-6-22(20)27/h4-7,10,13-14H,8-9,12H2,1-3H3,(H,29,30) CDNBNWUIUFKCCC-UHFFFAOYSA-N 513683 US11091495, Example 44::US11220509, Example 44::US11485738, Example 44 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513683&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788034 459630915 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221477 CN(C)C(=O)c1c(F)cc(cc1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H19F3N6O2/c1-33(2)24(35)22-19(27)7-13(8-20(22)28)16-10-30-25(34-12-14(9-29)32-23(16)34)31-11-17-15-5-6-36-21(15)4-3-18(17)26/h3-4,7-8,10,12H,5-6,11H2,1-2H3,(H,30,31) SBOLYPVWXJADNQ-UHFFFAOYSA-N 513684 US11091495, Example 45::US11220509, Example 45::US11485738, Example 45 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513684&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788018 459630916 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221478 Fc1ccc2OCCc2c1CNc1ncc(-c2ccccc2)c2nc(cn12)C#N InChI=1S/C22H16FN5O/c23-19-6-7-20-16(8-9-29-20)18(19)12-26-22-25-11-17(14-4-2-1-3-5-14)21-27-15(10-24)13-28(21)22/h1-7,11,13H,8-9,12H2,(H,25,26) YNCFEDAZGLIDEG-UHFFFAOYSA-N 513685 US11091495, Example 46::US11220509, Example 46::US11485738, Example 46 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513685&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788099 459630917 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221479 NS(=O)(=O)c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H17FN6O3S/c23-19-5-6-20-16(7-8-32-20)18(19)11-27-22-26-10-17(21-28-14(9-24)12-29(21)22)13-1-3-15(4-2-13)33(25,30)31/h1-6,10,12H,7-8,11H2,(H,26,27)(H2,25,30,31) HIYZTXIRVSPJIP-UHFFFAOYSA-N 513686 US11091495, Example 47::US11220509, Example 47::US11485738, Example 47 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513686&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788155 459630918 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221480 CN(C)S(=O)(=O)c1ccc(c(C)c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H23FN6O3S/c1-15-10-17(36(33,34)31(2)3)4-5-18(15)21-13-29-25(32-14-16(11-27)30-24(21)32)28-12-20-19-8-9-35-23(19)7-6-22(20)26/h4-7,10,13-14H,8-9,12H2,1-3H3,(H,28,29) YWKQPPBXESIUPC-UHFFFAOYSA-N 513687 US11091495, Example 48::US11220509, Example 48::US11485738, Example 48 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513687&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788140 459630919 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221481 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(CN3CCCC3=O)cc2)c2nc(cn12)C#N InChI=1S/C27H23FN6O2/c28-23-7-8-24-20(9-11-36-24)22(23)14-31-27-30-13-21(26-32-19(12-29)16-34(26)27)18-5-3-17(4-6-18)15-33-10-1-2-25(33)35/h3-8,13,16H,1-2,9-11,14-15H2,(H,30,31) QTWMEBMCPCUWIG-UHFFFAOYSA-N 513688 US11091495, Example 49::US11220509, Example 49::US11485738, Example 49 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513688&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788062 459630920 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221482 COC1CN(Cc2ccc(cc2)-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C#N)C1 InChI=1S/C27H25FN6O2/c1-35-20-15-33(16-20)13-17-2-4-18(5-3-17)22-11-30-27(34-14-19(10-29)32-26(22)34)31-12-23-21-8-9-36-25(21)7-6-24(23)28/h2-7,11,14,20H,8-9,12-13,15-16H2,1H3,(H,30,31) ITCWWKZLXUDHPA-UHFFFAOYSA-N 513689 US11091495, Example 50::US11220509, Example 50::US11485738, Example 50 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513689&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788049 459630921 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221483 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(CN3CC(F)(F)C3)cc2)c2nc(cn12)C#N InChI=1S/C26H21F3N6O/c27-22-5-6-23-19(7-8-36-23)21(22)11-32-25-31-10-20(24-33-18(9-30)13-35(24)25)17-3-1-16(2-4-17)12-34-14-26(28,29)15-34/h1-6,10,13H,7-8,11-12,14-15H2,(H,31,32) JZAOZAYCVNLZHL-UHFFFAOYSA-N 513690 US11091495, Example 51::US11220509, Example 51::US11485738, Example 51 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513690&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787977 459630922 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221484 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(CN3CC4CC4C3)cc2)c2nc(cn12)C#N InChI=1S/C28H25FN6O/c29-25-5-6-26-22(7-8-36-26)24(25)12-32-28-31-11-23(27-33-21(10-30)16-35(27)28)18-3-1-17(2-4-18)13-34-14-19-9-20(19)15-34/h1-6,11,16,19-20H,7-9,12-15H2,(H,31,32) QITBYXGVRFCEIQ-UHFFFAOYSA-N 513691 US11091495, Example 52::US11220509, Example 52::US11485738, Example 52 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513691&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788014 459630923 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221485 COC1CCN(Cc2ccc(cc2)-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C#N)C1 InChI=1S/C28H27FN6O2/c1-36-21-8-10-34(17-21)15-18-2-4-19(5-3-18)23-13-31-28(35-16-20(12-30)33-27(23)35)32-14-24-22-9-11-37-26(22)7-6-25(24)29/h2-7,13,16,21H,8-11,14-15,17H2,1H3,(H,31,32) GVDRINQOIIDDSC-UHFFFAOYSA-N 513692 US11091495, Example 53::US11220509, Example 53::US11485738, Example 53 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513692&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788148 459630924 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221486 FC1CCN(Cc2ccc(cc2)-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C#N)C1 InChI=1S/C27H24F2N6O/c28-19-7-9-34(15-19)14-17-1-3-18(4-2-17)22-12-31-27(35-16-20(11-30)33-26(22)35)32-13-23-21-8-10-36-25(21)6-5-24(23)29/h1-6,12,16,19H,7-10,13-15H2,(H,31,32) PSLHZKVMOWERSW-UHFFFAOYSA-N 513693 US11091495, Example 54::US11220509, Example 54::US11485738, Example 54 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513693&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788167 459630925 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221487 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(CN3CCC(F)(F)C3)cc2)c2nc(cn12)C#N InChI=1S/C27H23F3N6O/c28-23-5-6-24-20(7-10-37-24)22(23)13-33-26-32-12-21(25-34-19(11-31)15-36(25)26)18-3-1-17(2-4-18)14-35-9-8-27(29,30)16-35/h1-6,12,15H,7-10,13-14,16H2,(H,32,33) OSVFUMKEOIGMJL-UHFFFAOYSA-N 513694 US11091495, Example 55::US11220509, Example 55::US11485738, Example 55 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513694&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787975 459630926 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221488 Cc1nc(ccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N)N1CCOCC1 InChI=1S/C26H24FN7O2/c1-16-18(2-5-24(31-16)33-7-10-35-11-8-33)21-14-30-26(34-15-17(12-28)32-25(21)34)29-13-20-19-6-9-36-23(19)4-3-22(20)27/h2-5,14-15H,6-11,13H2,1H3,(H,29,30) HAXSHUBRFSJHHL-UHFFFAOYSA-N 513695 US11091495, Example 56::US11220509, Example 56::US11485738, Example 56 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513695&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788153 459630927 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221489 Fc1ccc2OCCc2c1CNc1ncc(-c2ccncn2)c2nc(cn12)C#N InChI=1S/C20H14FN7O/c21-16-1-2-18-13(4-6-29-18)14(16)8-24-20-25-9-15(17-3-5-23-11-26-17)19-27-12(7-22)10-28(19)20/h1-3,5,9-11H,4,6,8H2,(H,24,25) HGXPHBPWDKDDFU-UHFFFAOYSA-N 513696 US11091495, Example 57::US11220509, Example 57::US11485738, Example 57 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513696&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788000 459630928 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221490 CN(C)S(=O)(=O)c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C24H21FN6O3S/c1-30(2)35(32,33)17-5-3-15(4-6-17)19-12-27-24(31-14-16(11-26)29-23(19)31)28-13-20-18-9-10-34-22(18)8-7-21(20)25/h3-8,12,14H,9-10,13H2,1-2H3,(H,27,28) PCYOCVZDIXMWFX-UHFFFAOYSA-N 513697 US11091495, Example 58::US11220509, Example 58::US11485738, Example 58 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513697&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788121 459630929 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221491 CNS(=O)(=O)c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H19FN6O3S/c1-26-34(31,32)16-4-2-14(3-5-16)18-11-27-23(30-13-15(10-25)29-22(18)30)28-12-19-17-8-9-33-21(17)7-6-20(19)24/h2-7,11,13,26H,8-9,12H2,1H3,(H,27,28) BEOXBKXWKLTLHX-UHFFFAOYSA-N 513698 US11091495, Example 59::US11220509, Example 59::US11485738, Example 59 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513698&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788015 459630930 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221492 CN(C)c1ccc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H20FN7O/c1-30(2)21-6-3-14(10-26-21)17-11-27-23(31-13-15(9-25)29-22(17)31)28-12-18-16-7-8-32-20(16)5-4-19(18)24/h3-6,10-11,13H,7-8,12H2,1-2H3,(H,27,28) OIUVPGNVYNJGQN-UHFFFAOYSA-N 513699 US11091495, Example 60::US11220509, Example 60::US11485738, Example 60 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513699&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788159 459630931 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221493 CN(C)Cc1ccc(c(F)c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H22F2N6O/c1-32(2)13-15-3-4-17(22(27)9-15)20-12-30-25(33-14-16(10-28)31-24(20)33)29-11-19-18-7-8-34-23(18)6-5-21(19)26/h3-6,9,12,14H,7-8,11,13H2,1-2H3,(H,29,30) MLQLNAXQUYOTLN-UHFFFAOYSA-N 513700 US11091495, Example 61::US11220509, Example 61::US11485738, Example 61 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513700&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788105 459630932 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221494 Cc1ncc(F)cc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H16F2N6O/c1-12-16(6-13(23)8-26-12)18-10-28-22(30-11-14(7-25)29-21(18)30)27-9-17-15-4-5-31-20(15)3-2-19(17)24/h2-3,6,8,10-11H,4-5,9H2,1H3,(H,27,28) HFWXAOLDLCURON-UHFFFAOYSA-N 513701 US11091495, Example 62::US11220509, Example 62::US11485738, Example 62 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513701&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788139 459630933 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221495 CN(C)Cc1ccc(cc1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H22F2N6O/c1-32(2)13-16-4-3-15(9-22(16)27)19-11-29-25(33-14-17(10-28)31-24(19)33)30-12-20-18-7-8-34-23(18)6-5-21(20)26/h3-6,9,11,14H,7-8,12-13H2,1-2H3,(H,29,30) SGJOGTJTJMZXLP-UHFFFAOYSA-N 513702 US11091495, Example 63::US11220509, Example 63::US11485738, Example 85 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513702&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788038 459630934 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221496 FC(F)c1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H15F3N6O/c23-17-3-4-18-13(5-7-32-18)15(17)9-28-22-29-10-16(21-30-12(8-26)11-31(21)22)14-2-1-6-27-19(14)20(24)25/h1-4,6,10-11,20H,5,7,9H2,(H,28,29) MYKJLXMXCKCHON-UHFFFAOYSA-N 513703 US11091495, Example 64::US11220509, Example 64::US11485738, Example 64 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513703&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788013 459630935 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221497 C[C@H](O)Cn1nc(C)c(c1C)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C24H24FN7O2/c1-13(33)11-32-15(3)22(14(2)30-32)19-10-28-24(31-12-16(8-26)29-23(19)31)27-9-18-17-6-7-34-21(17)5-4-20(18)25/h4-5,10,12-13,33H,6-7,9,11H2,1-3H3,(H,27,28)/t13-/m0/s1 IVAOQLVFWWHVBQ-ZDUSSCGKSA-N 513704 US11091495, Example 65::US11220509, Example 65::US11485738, Example 65 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513704&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788066 459630936 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221498 C[C@@H](O)Cn1nc(C)c(c1C)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C24H24FN7O2/c1-13(33)11-32-15(3)22(14(2)30-32)19-10-28-24(31-12-16(8-26)29-23(19)31)27-9-18-17-6-7-34-21(17)5-4-20(18)25/h4-5,10,12-13,33H,6-7,9,11H2,1-3H3,(H,27,28)/t13-/m1/s1 IVAOQLVFWWHVBQ-CYBMUJFWSA-N 513705 US11091495, Example 66::US11220509, Example 66::US11485738, Example 66 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513705&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788110 459630937 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221499 Cc1ccc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H19FN6O/c1-13-3-4-16(14(2)28-13)19-11-27-23(30-12-15(9-25)29-22(19)30)26-10-18-17-7-8-31-21(17)6-5-20(18)24/h3-6,11-12H,7-8,10H2,1-2H3,(H,26,27) HIGOXWKPMUKWLM-UHFFFAOYSA-N 513706 US11091495, Example 67::US11220509, Example 67::US11485738, Example 67 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513706&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788012 459630938 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221500 Fc1ccc2OCCc2c1CNc1ncc(-c2cnccn2)c2nc(cn12)C#N InChI=1S/C20H14FN7O/c21-16-1-2-18-13(3-6-29-18)14(16)8-25-20-26-9-15(17-10-23-4-5-24-17)19-27-12(7-22)11-28(19)20/h1-2,4-5,9-11H,3,6,8H2,(H,25,26) UNEPUTDIPANHMW-UHFFFAOYSA-N 513707 US11091495, Example 68::US11220509, Example 68::US11485738, Example 68 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513707&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788004 459630939 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221501 Cc1ncc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C21H16FN7O/c1-12-24-7-13(8-25-12)16-9-26-21(29-11-14(6-23)28-20(16)29)27-10-17-15-4-5-30-19(15)3-2-18(17)22/h2-3,7-9,11H,4-5,10H2,1H3,(H,26,27) YUVQFUKCWVZXOX-UHFFFAOYSA-N 513708 US11091495, Example 69::US11220509, Example 69::US11485738, Example 69 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513708&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788059 459630940 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221502 Fc1ccc2OCCc2c1CNc1ncc(-c2cnc(cn2)C2CC2)c2nc(cn12)C#N InChI=1S/C23H18FN7O/c24-18-3-4-21-15(5-6-32-21)16(18)8-28-23-29-9-17(22-30-14(7-25)12-31(22)23)20-11-26-19(10-27-20)13-1-2-13/h3-4,9-13H,1-2,5-6,8H2,(H,28,29) POISDRPSNSJPRA-UHFFFAOYSA-N 513709 US11091495, Example 70::US11485738, Example 70 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513709&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788160 459630941 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221503 Cc1ncc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H18FN7O/c1-12-16(8-25-13(2)28-12)18-10-27-22(30-11-14(7-24)29-21(18)30)26-9-17-15-5-6-31-20(15)4-3-19(17)23/h3-4,8,10-11H,5-6,9H2,1-2H3,(H,26,27) NDGRAKQYTFCDKJ-UHFFFAOYSA-N 513710 US11091495, Example 71::US11220509, Example 71::US11485738, Example 71 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513710&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788131 459630942 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221504 Cc1nn(C)cc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C21H18FN7O/c1-12-17(11-28(2)27-12)16-9-25-21(29-10-13(7-23)26-20(16)29)24-8-15-14-5-6-30-19(14)4-3-18(15)22/h3-4,9-11H,5-6,8H2,1-2H3,(H,24,25) BURNSCKMTRTJLO-UHFFFAOYSA-N 513711 US11091495, Example 72::US11220509, Example 72::US11485738, Example 72 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513711&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788149 459630943 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221505 CS(=O)(=O)c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H18FN5O3S/c1-33(30,31)16-4-2-14(3-5-16)18-11-26-23(29-13-15(10-25)28-22(18)29)27-12-19-17-8-9-32-21(17)7-6-20(19)24/h2-7,11,13H,8-9,12H2,1H3,(H,26,27) OTMZQUYQWBEIIO-UHFFFAOYSA-N 513712 US11091495, Example 73::US11220509, Example 73::US11485738, Example 73 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513712&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788095 459630944 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221506 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(CN3CCCC3)cc2)c2nc(cn12)C#N InChI=1S/C27H25FN6O/c28-24-7-8-25-21(9-12-35-25)23(24)15-31-27-30-14-22(26-32-20(13-29)17-34(26)27)19-5-3-18(4-6-19)16-33-10-1-2-11-33/h3-8,14,17H,1-2,9-12,15-16H2,(H,30,31) ZXRAFGUYSHCCDE-UHFFFAOYSA-N 513713 US11091495, Example 74::US11220509, Example 74::US11485738, Example 74 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513713&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788114 459630945 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221507 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(CN3CCOCC3)cc2)c2nc(cn12)C#N InChI=1S/C27H25FN6O2/c28-24-5-6-25-21(7-10-36-25)23(24)15-31-27-30-14-22(26-32-20(13-29)17-34(26)27)19-3-1-18(2-4-19)16-33-8-11-35-12-9-33/h1-6,14,17H,7-12,15-16H2,(H,30,31) YEMHYUOUSNCKFN-UHFFFAOYSA-N 513714 US11091495, Example 75::US11220509, Example 75::US11485738, Example 75 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513714&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787999 459630946 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221508 CN(C)C(=O)c1cc(C)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H22FN7O2/c1-14-8-21(24(34)32(2)3)28-10-17(14)19-12-30-25(33-13-15(9-27)31-23(19)33)29-11-18-16-6-7-35-22(16)5-4-20(18)26/h4-5,8,10,12-13H,6-7,11H2,1-3H3,(H,29,30) LXXIUEJPNHZLJV-UHFFFAOYSA-N 513715 US11091495, Example 76::US11220509, Example 76::US11485738, Example 76 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513715&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788063 459630947 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221509 Fc1ccc2OCCc2c1CNc1ncc(C2CC2)c2nc(cn12)C#N InChI=1S/C19H16FN5O/c20-16-3-4-17-13(5-6-26-17)15(16)9-23-19-22-8-14(11-1-2-11)18-24-12(7-21)10-25(18)19/h3-4,8,10-11H,1-2,5-6,9H2,(H,22,23) VPOTVMSZBLPUBY-UHFFFAOYSA-N 513716 US11091495, Example 77::US11220509, Example 77::US11485738, Example 77 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513716&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788082 459630948 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221510 Cc1cc(-c2cnc(NCc3c(F)ccc4OCCCc34)n3cc(nc23)C#N)n(C)n1 InChI=1S/C22H20FN7O/c1-13-8-19(29(2)28-13)17-11-26-22(30-12-14(9-24)27-21(17)30)25-10-16-15-4-3-7-31-20(15)6-5-18(16)23/h5-6,8,11-12H,3-4,7,10H2,1-2H3,(H,25,26) AWZHWSXROUXLHE-UHFFFAOYSA-N 513761 US11091495, Example 122::US11220509, Example 78::US11485738, Example 122 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 >500 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513761&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788107 459630991 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221511 Cc1n[nH]cc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C20H16FN7O/c1-11-14(9-25-27-11)16-8-24-20(28-10-12(6-22)26-19(16)28)23-7-15-13-4-5-29-18(13)3-2-17(15)21/h2-3,8-10H,4-5,7H2,1H3,(H,23,24)(H,25,27) IAMONIMHFPXIFH-UHFFFAOYSA-N 513718 US11091495, Example 79::US11220509, Example 79::US11485738, Example 79 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513718&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788102 459630949 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221512 Fc1ccc2OCCc2c1CNc1ncc(-c2cnn3CCCc23)c2nc(cn12)C#N InChI=1S/C22H18FN7O/c23-18-3-4-20-14(5-7-31-20)15(18)9-25-22-26-10-17(21-28-13(8-24)12-29(21)22)16-11-27-30-6-1-2-19(16)30/h3-4,10-12H,1-2,5-7,9H2,(H,25,26) FRHGPEJXHCNFPB-UHFFFAOYSA-N 513719 US11091495, Example 80::US11220509, Example 80::US11485738, Example 80 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513719&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788054 459630950 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221513 Cc1cc(-c2cnc(NCc3c(F)ccc4sccc34)n3cc(nc23)C#N)n(C)n1 InChI=1S/C21H16FN7S/c1-12-7-18(28(2)27-12)16-10-25-21(29-11-13(8-23)26-20(16)29)24-9-15-14-5-6-30-19(14)4-3-17(15)22/h3-7,10-11H,9H2,1-2H3,(H,24,25) ZAZTYEGXVLGOOL-UHFFFAOYSA-N 513720 US11091495, Example 81::US11220509, Example 81::US11485738, Example 81 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 >500 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513720&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788108 459630951 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221514 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(cc2)S(=O)(=O)C(F)(F)F)c2nc(cn12)C#N InChI=1S/C23H15F4N5O3S/c24-19-5-6-20-16(7-8-35-20)18(19)11-30-22-29-10-17(21-31-14(9-28)12-32(21)22)13-1-3-15(4-2-13)36(33,34)23(25,26)27/h1-6,10,12H,7-8,11H2,(H,29,30) NKTNOHOGUWQKAQ-UHFFFAOYSA-N 513721 US11091495, Example 82::US11220509, Example 82::US11485738, Example 82 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513721&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787990 459630952 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221515 CN(C)Cc1ccc(c(Cl)c1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H21ClF2N6O/c1-33(2)12-14-3-4-17(22(26)23(14)28)19-11-31-25(34-13-15(9-29)32-24(19)34)30-10-18-16-7-8-35-21(16)6-5-20(18)27/h3-6,11,13H,7-8,10,12H2,1-2H3,(H,30,31) DKIXRKPUWWZSJK-UHFFFAOYSA-N 513722 US11091495, Example 83::US11220509, Example 83::US11485738, Example 83 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513722&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788069 459630953 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221516 CN(C)Cc1cc(C)c(cc1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H24F2N6O/c1-15-8-16(13-33(2)3)23(28)9-19(15)21-12-31-26(34-14-17(10-29)32-25(21)34)30-11-20-18-6-7-35-24(18)5-4-22(20)27/h4-5,8-9,12,14H,6-7,11,13H2,1-3H3,(H,30,31) XLQNMGXKIXDYJN-UHFFFAOYSA-N 513723 US11091495, Example 84::US11220509, Example 84::US11485738, Example 84 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513723&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788094 459630954 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221517 CN(C)Cc1ccc(cc1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H22F2N6O/c1-32(2)13-16-4-3-15(9-22(16)27)19-11-29-25(33-14-17(10-28)31-24(19)33)30-12-20-18-7-8-34-23(18)6-5-21(20)26/h3-6,9,11,14H,7-8,12-13H2,1-2H3,(H,29,30) SGJOGTJTJMZXLP-UHFFFAOYSA-N 513702 US11091495, Example 63::US11220509, Example 63::US11485738, Example 85 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513702&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788038 459630934 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221518 Cc1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C#N)n(C)n1 InChI=1S/C21H18FN7O/c1-12-7-18(28(2)27-12)16-10-25-21(29-11-13(8-23)26-20(16)29)24-9-15-14-5-6-30-19(14)4-3-17(15)22/h3-4,7,10-11H,5-6,9H2,1-2H3,(H,24,25) WUFADHRATSOXBZ-UHFFFAOYSA-N 513667 US11091495, Example 169::US11091495, Example 228::US11091495, Example 28::US11091495, Example 78::US11091495, Example 86::US11220509, Example 169::US11485738, Example 86 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513667&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 9L0 7SI5 152324986 459630899 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221519 Cc1cc(ccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N)S(C)(=O)=O InChI=1S/C24H20FN5O3S/c1-14-9-16(34(2,31)32)3-4-17(14)20-12-28-24(30-13-15(10-26)29-23(20)30)27-11-19-18-7-8-33-22(18)6-5-21(19)25/h3-6,9,12-13H,7-8,11H2,1-2H3,(H,27,28) FNHUVEMKBOXZIE-UHFFFAOYSA-N 513726 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(2-methyl-4-(methylsulfonyl)phenyl)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 87::US11220509, Example 87::US11485738, Example 87 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513726&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155369138 459630956 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221520 COc1ncc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H18FN7O2/c1-12-15(8-27-22(28-12)31-2)17-10-26-21(30-11-13(7-24)29-20(17)30)25-9-16-14-5-6-32-19(14)4-3-18(16)23/h3-4,8,10-11H,5-6,9H2,1-2H3,(H,25,26) OGKQBKDNMIMPLP-UHFFFAOYSA-N 513727 US11091495, Example 88::US11220509, Example 88::US11485738, Example 88 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513727&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787994 459630957 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221521 CC(C)Oc1ncc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C24H22FN7O2/c1-13(2)34-24-29-9-17(14(3)30-24)19-11-28-23(32-12-15(8-26)31-22(19)32)27-10-18-16-6-7-33-21(16)5-4-20(18)25/h4-5,9,11-13H,6-7,10H2,1-3H3,(H,27,28) KQJCRYVVEQPVFT-UHFFFAOYSA-N 513728 US11091495, Example 89::US11220509, Example 89::US11485738, Example 89 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513728&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788048 459630958 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221522 CC(N1CCCC1)c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C28H27FN6O/c1-18(34-11-2-3-12-34)19-4-6-20(7-5-19)23-15-31-28(35-17-21(14-30)33-27(23)35)32-16-24-22-10-13-36-26(22)9-8-25(24)29/h4-9,15,17-18H,2-3,10-13,16H2,1H3,(H,31,32) NJZZEOZWMRKMKY-UHFFFAOYSA-N 513729 US11091495, Example 90::US11220509, Example 90::US11485738, Example 90 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513729&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788020 459630959 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221523 COc1cc(Cl)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H16ClFN6O2/c1-31-20-6-17(23)14(8-26-20)16-10-28-22(30-11-12(7-25)29-21(16)30)27-9-15-13-4-5-32-19(13)3-2-18(15)24/h2-3,6,8,10-11H,4-5,9H2,1H3,(H,27,28) WFYHTTBNCRIVNL-UHFFFAOYSA-N 513730 US11091495, Example 91::US11220509, Example 91::US11485738, Example 91 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513730&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788032 459630960 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221524 CC(C)n1nc(C)c(c1C)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C24H24FN7O/c1-13(2)32-15(4)22(14(3)30-32)19-11-28-24(31-12-16(9-26)29-23(19)31)27-10-18-17-7-8-33-21(17)6-5-20(18)25/h5-6,11-13H,7-8,10H2,1-4H3,(H,27,28) JCFPVARYWWHQNE-UHFFFAOYSA-N 513731 US11091495, Example 92::US11220509, Example 92::US11485738, Example 92 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513731&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788123 459630961 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221525 COc1cncc(c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H17FN6O2/c1-30-15-6-13(8-25-9-15)17-10-26-22(29-12-14(7-24)28-21(17)29)27-11-18-16-4-5-31-20(16)3-2-19(18)23/h2-3,6,8-10,12H,4-5,11H2,1H3,(H,26,27) FWWWIHODKGFTKG-UHFFFAOYSA-N 513732 US11091495, Example 93::US11220509, Example 93::US11485738, Example 93 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513732&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788120 459630962 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221526 COc1ccc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H17FN6O2/c1-30-20-5-2-13(9-25-20)16-10-26-22(29-12-14(8-24)28-21(16)29)27-11-17-15-6-7-31-19(15)4-3-18(17)23/h2-5,9-10,12H,6-7,11H2,1H3,(H,26,27) KLSNAVOANZFTRJ-UHFFFAOYSA-N 513733 US11091495, Example 94::US11220509, Example 94::US11485738, Example 94 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513733&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788019 459630963 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221527 Fc1ccc2OCCc2c1CNc1ncc(-c2cncc(c2)C#N)c2nc(cn12)C#N InChI=1S/C22H14FN7O/c23-19-1-2-20-16(3-4-31-20)18(19)11-28-22-27-10-17(14-5-13(6-24)8-26-9-14)21-29-15(7-25)12-30(21)22/h1-2,5,8-10,12H,3-4,11H2,(H,27,28) XWNVGSZJRCDLBJ-UHFFFAOYSA-N 513734 US11091495, Example 95::US11220509, Example 95::US11485738, Example 95 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513734&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050902 459630964 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221528 Cc1cncc(c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H17FN6O/c1-13-6-14(9-25-8-13)17-10-26-22(29-12-15(7-24)28-21(17)29)27-11-18-16-4-5-30-20(16)3-2-19(18)23/h2-3,6,8-10,12H,4-5,11H2,1H3,(H,26,27) NQZHCLOREJNARD-UHFFFAOYSA-N 513735 US11091495, Example 96::US11220509, Example 96::US11485738, Example 96 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513735&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788079 459630965 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221529 Fc1cncc(c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C21H14F2N6O/c22-13-5-12(7-25-8-13)16-9-26-21(29-11-14(6-24)28-20(16)29)27-10-17-15-3-4-30-19(15)2-1-18(17)23/h1-2,5,7-9,11H,3-4,10H2,(H,26,27) MGFCUBHOHMZGJB-UHFFFAOYSA-N 513736 US11091495, Example 97::US11220509, Example 97::US11485738, Example 97 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513736&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788025 459630966 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221530 Cc1ccncc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H17FN6O/c1-13-4-6-25-9-16(13)18-11-27-22(29-12-14(8-24)28-21(18)29)26-10-17-15-5-7-30-20(15)3-2-19(17)23/h2-4,6,9,11-12H,5,7,10H2,1H3,(H,26,27) KNJWUVCWHYCFIS-UHFFFAOYSA-N 513737 US11091495, Example 98::US11220509, Example 98::US11485738, Example 98 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513737&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788022 459630967 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221531 CC(C)n1cc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H20FN7O/c1-13(2)30-11-14(8-27-30)17-9-25-22(29-12-15(7-24)28-21(17)29)26-10-18-16-5-6-31-20(16)4-3-19(18)23/h3-4,8-9,11-13H,5-6,10H2,1-2H3,(H,25,26) SRZSJRHVBCIUSX-UHFFFAOYSA-N 513738 US11091495, Example 99::US11220509, Example 99::US11485738, Example 99 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513738&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788042 459630968 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221532 Fc1ccc2OCCc2c1CNc1ncc(-c2cccnc2)c2nc(cn12)C#N InChI=1S/C21H15FN6O/c22-18-3-4-19-15(5-7-29-19)17(18)11-26-21-25-10-16(13-2-1-6-24-9-13)20-27-14(8-23)12-28(20)21/h1-4,6,9-10,12H,5,7,11H2,(H,25,26) MJCGGZHEKNGFCY-UHFFFAOYSA-N 513739 US11091495, Example 100::US11220509, Example 100::US11485738, Example 100 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513739&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787981 459630969 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221533 Fc1ccc2OCCc2c1CNc1ncc(-c2cnn(Cc3cccnc3)c2)c2nc(cn12)C#N InChI=1S/C25H19FN8O/c26-22-3-4-23-19(5-7-35-23)21(22)12-30-25-29-11-20(24-32-18(8-27)15-34(24)25)17-10-31-33(14-17)13-16-2-1-6-28-9-16/h1-4,6,9-11,14-15H,5,7,12-13H2,(H,29,30) PSEGDJQRHVDTGV-UHFFFAOYSA-N 513740 US11091495, Example 101::US11220509, Example 101::US11485738, Example 101 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513740&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788138 459630970 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221534 CN(C)CCn1cc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H23FN8O/c1-30(2)6-7-31-13-15(10-28-31)18-11-26-23(32-14-16(9-25)29-22(18)32)27-12-19-17-5-8-33-21(17)4-3-20(19)24/h3-4,10-11,13-14H,5-8,12H2,1-2H3,(H,26,27) ZZGXEORREMDNQW-UHFFFAOYSA-N 513741 US11091495, Example 102::US11220509, Example 102::US11485738, Example 102 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513741&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788136 459630971 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221535 CN(C)CCCn1cc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C24H25FN8O/c1-31(2)7-3-8-32-14-16(11-29-32)19-12-27-24(33-15-17(10-26)30-23(19)33)28-13-20-18-6-9-34-22(18)5-4-21(20)25/h4-5,11-12,14-15H,3,6-9,13H2,1-2H3,(H,27,28) HHMZECFYXRJRFF-UHFFFAOYSA-N 513742 US11091495, Example 103::US11220509, Example 103::US11485738, Example 103 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513742&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788008 459630972 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221536 Cc1n[nH]c(C)c1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C21H18FN7O/c1-11-19(12(2)28-27-11)16-9-25-21(29-10-13(7-23)26-20(16)29)24-8-15-14-5-6-30-18(14)4-3-17(15)22/h3-4,9-10H,5-6,8H2,1-2H3,(H,24,25)(H,27,28) NCSVBCQCTXBRFJ-UHFFFAOYSA-N 513743 US11091495, Example 104::US11220509, Example 104::US11485738, Example 104 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 >500 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513743&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788091 459630973 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221537 Cc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H17FN6O/c1-13-15(3-2-7-25-13)18-11-27-22(29-12-14(9-24)28-21(18)29)26-10-17-16-6-8-30-20(16)5-4-19(17)23/h2-5,7,11-12H,6,8,10H2,1H3,(H,26,27) WWHYMSGEEGSWLY-UHFFFAOYSA-N 513744 US11091495, Example 105::US11220509, Example 105::US11485738, Example 105 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513744&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676929 459630974 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221538 Fc1ccc2OCCc2c1CNc1ncc(-c2cnn(c2)C2COC2)c2nc(cn12)C#N InChI=1S/C22H18FN7O2/c23-19-1-2-20-16(3-4-32-20)18(19)8-26-22-25-7-17(21-28-14(5-24)10-29(21)22)13-6-27-30(9-13)15-11-31-12-15/h1-2,6-7,9-10,15H,3-4,8,11-12H2,(H,25,26) FMLGHOHHTMVNJR-UHFFFAOYSA-N 513745 US11091495, Example 106::US11220509, Example 106::US11485738, Example 106 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513745&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788006 459630975 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221539 Fc1ccc2OCCc2c1CNc1ncc(-c2cnn(c2)C2CCOC2)c2nc(cn12)C#N InChI=1S/C23H20FN7O2/c24-20-1-2-21-17(4-6-33-21)19(20)10-27-23-26-9-18(22-29-15(7-25)12-30(22)23)14-8-28-31(11-14)16-3-5-32-13-16/h1-2,8-9,11-12,16H,3-6,10,13H2,(H,26,27) LKKATWBZSSVMRX-UHFFFAOYSA-N 513746 US11091495, Example 107::US11220509, Example 107::US11485738, Example 107 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513746&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787991 459630976 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221540 Fc1ccc2OCCc2c1CNc1ncc(-c2cnn(CC(F)(F)F)c2)c2nc(cn12)C#N InChI=1S/C21H15F4N7O/c22-17-1-2-18-14(3-4-33-18)16(17)8-28-20-27-7-15(19-30-13(5-26)10-32(19)20)12-6-29-31(9-12)11-21(23,24)25/h1-2,6-7,9-10H,3-4,8,11H2,(H,27,28) DVZAJHCWPYSJMP-UHFFFAOYSA-N 513747 US11091495, Example 108::US11220509, Example 108::US11485738, Example 108 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513747&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050912 459630977 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221541 Fc1ccc2OCCc2c1CNc1ncc(-c2cnccc2Cl)c2nc(cn12)C#N InChI=1S/C21H14ClFN6O/c22-17-3-5-25-8-14(17)16-10-27-21(29-11-12(7-24)28-20(16)29)26-9-15-13-4-6-30-19(13)2-1-18(15)23/h1-3,5,8,10-11H,4,6,9H2,(H,26,27) NJOVETZRLXEYMT-UHFFFAOYSA-N 513748 US11091495, Example 109::US11220509, Example 109::US11485738, Example 109 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513748&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788128 459630978 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221542 Cc1ncncc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C21H16FN7O/c1-12-15(7-24-11-27-12)17-9-26-21(29-10-13(6-23)28-20(17)29)25-8-16-14-4-5-30-19(14)3-2-18(16)22/h2-3,7,9-11H,4-5,8H2,1H3,(H,25,26) WRTWCLLYZVOLPM-UHFFFAOYSA-N 513749 US11091495, Example 110::US11220509, Example 110::US11485738, Example 110 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513749&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788003 459630979 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221543 Cn1nc(cc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N)C(F)(F)F InChI=1S/C21H15F4N7O/c1-31-16(6-18(30-31)21(23,24)25)14-9-28-20(32-10-11(7-26)29-19(14)32)27-8-13-12-4-5-33-17(12)3-2-15(13)22/h2-3,6,9-10H,4-5,8H2,1H3,(H,27,28) KKQYWOJEQUGBDY-UHFFFAOYSA-N 513750 US11091495, Example 111::US11220509, Example 111::US11485738, Example 111 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513750&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050908 459630980 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221544 CN(C)Cc1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H23FN6O/c1-31(2)14-16-3-5-17(6-4-16)20-12-28-25(32-15-18(11-27)30-24(20)32)29-13-21-19-9-10-33-23(19)8-7-22(21)26/h3-8,12,15H,9-10,13-14H2,1-2H3,(H,28,29) JJCZYCVSGAQWBL-UHFFFAOYSA-N 513751 US11091495, Example 112::US11091495, Example 165::US11220509, Example 165::US11485738, Example 165 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513751&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788075 459630981 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221545 COc1cc(ccn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H17FN6O2/c1-30-20-8-13(4-6-25-20)16-10-26-22(29-12-14(9-24)28-21(16)29)27-11-17-15-5-7-31-19(15)3-2-18(17)23/h2-4,6,8,10,12H,5,7,11H2,1H3,(H,26,27) JOSMIOOHLINXGW-UHFFFAOYSA-N 513752 US11091495, Example 113::US11091495, Example 218::US11220509, Example 218::US11485738, Example 113 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513752&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676980 459630982 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221546 Cn1nccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C20H16FN7O/c1-27-17(4-6-25-27)15-10-24-20(28-11-12(8-22)26-19(15)28)23-9-14-13-5-7-29-18(13)3-2-16(14)21/h2-4,6,10-11H,5,7,9H2,1H3,(H,23,24) ZBMIGKSBOCAYQM-UHFFFAOYSA-N 513753 US11091495, Example 114::US11091495, Example 157::US11220509, Example 157::US11485738, Example 157 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513753&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788092 459630983 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221547 CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C28H26FN7O2/c1-34-9-11-35(12-10-34)27(37)19-4-2-18(3-5-19)22-15-31-28(36-17-20(14-30)33-26(22)36)32-16-23-21-8-13-38-25(21)7-6-24(23)29/h2-7,15,17H,8-13,16H2,1H3,(H,31,32) AFIVAVZMDHGHDE-UHFFFAOYSA-N 513754 US11091495, Example 115::US11220509, Example 115::US11485738, Example 115 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513754&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788132 459630984 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221548 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(nc2)C2CC2)c2nc(cn12)C#N InChI=1S/C24H19FN6O/c25-20-4-6-22-17(7-8-32-22)19(20)12-29-24-28-11-18(23-30-16(9-26)13-31(23)24)15-3-5-21(27-10-15)14-1-2-14/h3-6,10-11,13-14H,1-2,7-8,12H2,(H,28,29) KRLSHLVXXMNOQV-UHFFFAOYSA-N 513755 US11091495, Example 116::US11220509, Example 116::US11485738, Example 116 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513755&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788163 459630985 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221549 COCCn1cc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H20FN7O2/c1-31-7-5-29-12-14(9-27-29)17-10-25-22(30-13-15(8-24)28-21(17)30)26-11-18-16-4-6-32-20(16)3-2-19(18)23/h2-3,9-10,12-13H,4-7,11H2,1H3,(H,25,26) LOFNQEPSCRGCDL-UHFFFAOYSA-N 513756 US11091495, Example 117::US11220509, Example 117::US11485738, Example 117 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513756&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050929 459630986 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221550 Fc1ccc2OCCc2c1CNc1ncc(-c2cnn(c2)C2CCCCO2)c2nc(cn12)C#N InChI=1S/C24H22FN7O2/c25-20-4-5-21-17(6-8-33-21)19(20)12-28-24-27-11-18(23-30-16(9-26)14-31(23)24)15-10-29-32(13-15)22-3-1-2-7-34-22/h4-5,10-11,13-14,22H,1-3,6-8,12H2,(H,27,28) SRCGBYDIZKQDAX-UHFFFAOYSA-N 513757 US11091495, Example 118::US11220509, Example 118::US11485738, Example 118 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513757&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788076 459630987 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221551 CCn1cc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C21H18FN7O/c1-2-28-11-13(8-26-28)16-9-24-21(29-12-14(7-23)27-20(16)29)25-10-17-15-5-6-30-19(15)4-3-18(17)22/h3-4,8-9,11-12H,2,5-6,10H2,1H3,(H,24,25) PXLOKXJRSWVFRW-UHFFFAOYSA-N 513758 US11091495, Example 119::US11220509, Example 119::US11485738, Example 119 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513758&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788031 459630988 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221552 Fc1ccc2OCCc2c1CNc1ncc(-c2cnn(c2)C2CCOCC2)c2nc(cn12)C#N InChI=1S/C24H22FN7O2/c25-21-1-2-22-18(5-8-34-22)20(21)12-28-24-27-11-19(23-30-16(9-26)14-31(23)24)15-10-29-32(13-15)17-3-6-33-7-4-17/h1-2,10-11,13-14,17H,3-8,12H2,(H,27,28) XIIVQYTVPLVMKJ-UHFFFAOYSA-N 513759 US11091495, Example 120::US11220509, Example 120::US11485738, Example 120 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 >500 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513759&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788040 459630989 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221553 CC(C)(O)Cn1cc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H22FN7O2/c1-23(2,32)13-30-11-14(8-28-30)17-9-26-22(31-12-15(7-25)29-21(17)31)27-10-18-16-5-6-33-20(16)4-3-19(18)24/h3-4,8-9,11-12,32H,5-6,10,13H2,1-2H3,(H,26,27) YXCILEJYVNSKQL-UHFFFAOYSA-N 513760 US11091495, Example 121::US11220509, Example 121::US11485738, Example 121 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513760&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788077 459630990 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221554 Cc1cc(-c2cnc(NCc3c(F)ccc4OCCCc34)n3cc(nc23)C#N)n(C)n1 InChI=1S/C22H20FN7O/c1-13-8-19(29(2)28-13)17-11-26-22(30-12-14(9-24)27-21(17)30)25-10-16-15-4-3-7-31-20(15)6-5-18(16)23/h5-6,8,11-12H,3-4,7,10H2,1-2H3,(H,25,26) AWZHWSXROUXLHE-UHFFFAOYSA-N 513761 US11091495, Example 122::US11220509, Example 78::US11485738, Example 122 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 >500 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513761&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788107 459630991 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221555 COc1cc(c(F)cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H16F2N6O2/c1-31-20-6-14(18(24)10-26-20)16-9-28-22(30-11-12(7-25)29-21(16)30)27-8-15-13-4-5-32-19(13)3-2-17(15)23/h2-3,6,9-11H,4-5,8H2,1H3,(H,27,28) KBHWQKQMPMAPEO-UHFFFAOYSA-N 513762 US11091495, Example 123::US11220509, Example 123::US11485738, Example 123 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513762&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788173 459630992 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221556 CCOc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H19FN6O2/c1-2-31-22-16(4-3-8-26-22)18-12-28-23(30-13-14(10-25)29-21(18)30)27-11-17-15-7-9-32-20(15)6-5-19(17)24/h3-6,8,12-13H,2,7,9,11H2,1H3,(H,27,28) DLBFMDGNSNIQBA-UHFFFAOYSA-N 513763 US11091495, Example 124::US11220509, Example 124::US11485738, Example 124 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513763&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787976 459630993 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221557 COc1cc(c(OC)cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H19FN6O3/c1-31-20-11-26-21(32-2)7-15(20)17-10-28-23(30-12-13(8-25)29-22(17)30)27-9-16-14-5-6-33-19(14)4-3-18(16)24/h3-4,7,10-12H,5-6,9H2,1-2H3,(H,27,28) XCVAPCIFZZYYCH-UHFFFAOYSA-N 513764 US11091495, Example 125::US11220509, Example 125::US11485738, Example 125 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513764&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050914 459630994 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221558 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(nc2)C(F)(F)F)c2nc(cn12)C#N InChI=1S/C22H14F4N6O/c23-17-2-3-18-14(5-6-33-18)16(17)10-30-21-29-9-15(20-31-13(7-27)11-32(20)21)12-1-4-19(28-8-12)22(24,25)26/h1-4,8-9,11H,5-6,10H2,(H,29,30) ATZNRHWOJZFKOP-UHFFFAOYSA-N 513765 US11091495, Example 126::US11220509, Example 126::US11485738, Example 126 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513765&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788183 459630995 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221559 Nc1ccc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C21H16FN7O/c22-17-2-3-18-14(5-6-30-18)16(17)10-27-21-26-9-15(12-1-4-19(24)25-8-12)20-28-13(7-23)11-29(20)21/h1-4,8-9,11H,5-6,10H2,(H2,24,25)(H,26,27) JFZRZAWOKSELHZ-UHFFFAOYSA-N 513766 US11091495, Example 127::US11220509, Example 127::US11485738, Example 127 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513766&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787986 459630996 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221560 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(nc2)C#N)c2nc(cn12)C#N InChI=1S/C22H14FN7O/c23-19-3-4-20-16(5-6-31-20)18(19)11-28-22-27-10-17(13-1-2-14(7-24)26-9-13)21-29-15(8-25)12-30(21)22/h1-4,9-10,12H,5-6,11H2,(H,27,28) ZTXVMQSYTYCODC-UHFFFAOYSA-N 513767 US11091495, Example 128::US11220509, Example 128::US11485738, Example 128 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513767&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788142 459630997 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221561 Cc1ncc(cc1N)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H18FN7O/c1-12-19(25)6-13(8-26-12)16-9-27-22(30-11-14(7-24)29-21(16)30)28-10-17-15-4-5-31-20(15)3-2-18(17)23/h2-3,6,8-9,11H,4-5,10,25H2,1H3,(H,27,28) QQAWSQZIJXYDOY-UHFFFAOYSA-N 513768 US11091495, Example 129::US11220509, Example 129::US11485738, Example 129 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513768&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788118 459630998 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221562 COc1ncc(cc1C#N)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H16FN7O2/c1-32-22-13(7-25)6-14(9-27-22)17-10-28-23(31-12-15(8-26)30-21(17)31)29-11-18-16-4-5-33-20(16)3-2-19(18)24/h2-3,6,9-10,12H,4-5,11H2,1H3,(H,28,29) MBNDUVZCCABKGK-UHFFFAOYSA-N 513769 US11091495, Example 130::US11220509, Example 130::US11485738, Example 130 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513769&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156051042 459630999 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221563 CC(=O)Nc1cc(ccn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H18FN7O2/c1-13(32)29-21-8-14(4-6-26-21)17-10-27-23(31-12-15(9-25)30-22(17)31)28-11-18-16-5-7-33-20(16)3-2-19(18)24/h2-4,6,8,10,12H,5,7,11H2,1H3,(H,27,28)(H,26,29,32) BSLHODUXHOPITF-UHFFFAOYSA-N 513770 US11091495, Example 131::US11220509, Example 131::US11485738, Example 131 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513770&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156051101 459631000 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221564 Fc1ccc2OCCc2c1CNc1ncc(-c2cncc(c2)C(F)(F)F)c2nc(cn12)C#N InChI=1S/C22H14F4N6O/c23-18-1-2-19-15(3-4-33-19)17(18)10-30-21-29-9-16(20-31-14(6-27)11-32(20)21)12-5-13(8-28-7-12)22(24,25)26/h1-2,5,7-9,11H,3-4,10H2,(H,29,30) RDFNWSIEQYEMGF-UHFFFAOYSA-N 513771 US11091495, Example 132::US11220509, Example 132::US11485738, Example 132 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 >500 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513771&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050987 459631001 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221565 CC(C)Oc1ccc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C24H21FN6O2/c1-14(2)33-22-6-3-15(10-27-22)18-11-28-24(31-13-16(9-26)30-23(18)31)29-12-19-17-7-8-32-21(17)5-4-20(19)25/h3-6,10-11,13-14H,7-8,12H2,1-2H3,(H,28,29) FGQHIQLXPWEHGC-UHFFFAOYSA-N 513772 US11091495, Example 133::US11220509, Example 133::US11485738, Example 133 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513772&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788124 459631002 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221566 Nc1ncc(cc1C(F)(F)F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H15F4N7O/c23-17-1-2-18-13(3-4-34-18)15(17)9-31-21-30-8-14(20-32-12(6-27)10-33(20)21)11-5-16(22(24,25)26)19(28)29-7-11/h1-2,5,7-8,10H,3-4,9H2,(H2,28,29)(H,30,31) QNMGGALOHIVPOS-UHFFFAOYSA-N 513773 US11091495, Example 134::US11220509, Example 134::US11485738, Example 134 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513773&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050985 459631003 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221567 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(nc2)N2CCCCC2)c2nc(cn12)C#N InChI=1S/C26H24FN7O/c27-22-5-6-23-19(8-11-35-23)21(22)15-31-26-30-14-20(25-32-18(12-28)16-34(25)26)17-4-7-24(29-13-17)33-9-2-1-3-10-33/h4-7,13-14,16H,1-3,8-11,15H2,(H,30,31) VNOSDQWLFVYWRT-UHFFFAOYSA-N 513774 US11091495, Example 135::US11220509, Example 135::US11485738, Example 135 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513774&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788009 459631004 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221568 CN1CCN(CC1)c1ccc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C27H27FN8O/c1-17-19(3-6-25(32-17)35-10-8-34(2)9-11-35)22-15-31-27(36-16-18(13-29)33-26(22)36)30-14-21-20-7-12-37-24(20)5-4-23(21)28/h3-6,15-16H,7-12,14H2,1-2H3,(H,30,31) JXCUQVXZOACSJW-UHFFFAOYSA-N 513775 US11091495, Example 136::US11220509, Example 136::US11485738, Example 136 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513775&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676932 459631005 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221569 Cc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C(N)=O InChI=1S/C22H19FN6O2/c1-12-13(3-2-7-25-12)16-10-27-22(29-11-18(20(24)30)28-21(16)29)26-9-15-14-6-8-31-19(14)5-4-17(15)23/h2-5,7,10-11H,6,8-9H2,1H3,(H2,24,30)(H,26,27) BCXVBFNEZHMBTI-UHFFFAOYSA-N 513776 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(2-methylpyridin-3-yl)imidazo[1,2-c]pyrimidine-2-carboxamide::US11091495, Example 137::US11220509, Example 137::US11485738, Example 137 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513776&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676996 459631006 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221570 CN1CCN(CC1)c1ccc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C(N)=O InChI=1S/C27H29FN8O2/c1-16-17(3-6-24(32-16)35-10-8-34(2)9-11-35)20-14-31-27(36-15-22(25(29)37)33-26(20)36)30-13-19-18-7-12-38-23(18)5-4-21(19)28/h3-6,14-15H,7-13H2,1-2H3,(H2,29,37)(H,30,31) HMXDXCDZOLIXOJ-UHFFFAOYSA-N 513777 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(2-methyl-6-(4-methylpiperazin-1-yl)pyridin-3-yl)imidazo[1,2-c]pyrimidine-2-carboxamide::US11091495, Example 138::US11220509, Example 138::US11485738, Example 138 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513777&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676923 459631007 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221571 Cc1cn(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C20H16FN7O/c1-12-9-27(11-25-12)17-8-24-20(28-10-13(6-22)26-19(17)28)23-7-15-14-4-5-29-18(14)3-2-16(15)21/h2-3,8-11H,4-5,7H2,1H3,(H,23,24) QRYIPSSFSKCWDG-UHFFFAOYSA-N 513778 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(4-methyl-1H-imidazol-1-yl)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 139::US11220509, Example 139::US11485738, Example 139 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513778&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139371908 459631008 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221572 Fc1ccc2OCCc2c1CNc1ncc(C2CCNCC2)c2nc(cn12)C#N InChI=1S/C21H21FN6O/c22-18-1-2-19-15(5-8-29-19)17(18)11-26-21-25-10-16(13-3-6-24-7-4-13)20-27-14(9-23)12-28(20)21/h1-2,10,12-13,24H,3-8,11H2,(H,25,26) USKDFXYKTAACBI-UHFFFAOYSA-N 580256 US11485738, Example 140 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 >500 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580256&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676928 475726110 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221573 Fc1ccc2OCCc2c1CNc1ncc(C2CCOCC2)c2nc(cn12)C#N InChI=1S/C21H20FN5O2/c22-18-1-2-19-15(5-8-29-19)17(18)11-25-21-24-10-16(13-3-6-28-7-4-13)20-26-14(9-23)12-27(20)21/h1-2,10,12-13H,3-8,11H2,(H,24,25) JRCAHVGSMADQHZ-UHFFFAOYSA-N 580257 US11485738, Example 141 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 >500 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580257&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676908 475726111 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221574 Fc1ccc2OCCc2c1CNc1ncc(-c2cccnn2)c2nc(cn12)C#N InChI=1S/C20H14FN7O/c21-16-3-4-18-13(5-7-29-18)14(16)9-23-20-24-10-15(17-2-1-6-25-27-17)19-26-12(8-22)11-28(19)20/h1-4,6,10-11H,5,7,9H2,(H,23,24) YNRNVHJGNIKGPW-UHFFFAOYSA-N 533500 US11220509, Example 142::US11485738, Example 142 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=533500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=533500&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221575 Cn1nncc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C19H15FN8O/c1-27-16(9-24-26-27)14-8-23-19(28-10-11(6-21)25-18(14)28)22-7-13-12-4-5-29-17(12)3-2-15(13)20/h2-3,8-10H,4-5,7H2,1H3,(H,22,23) BDIUGQUKSKTIGY-UHFFFAOYSA-N 513782 US11091495, Example 143::US11220509, Example 143::US11485738, Example 143 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513782&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788030 459631012 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221576 Cn1nc(cc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N)C1CC1 InChI=1S/C23H20FN7O/c1-30-20(8-19(29-30)13-2-3-13)17-11-27-23(31-12-14(9-25)28-22(17)31)26-10-16-15-6-7-32-21(15)5-4-18(16)24/h4-5,8,11-13H,2-3,6-7,10H2,1H3,(H,26,27) QMVWJEHSIZKLEM-UHFFFAOYSA-N 513783 US11091495, Example 144::US11220509, Example 144::US11485738, Example 144 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513783&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788098 459631013 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221577 Cc1nc(c(C)s1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C21H17FN6OS/c1-11-19(26-12(2)30-11)16-9-25-21(28-10-13(7-23)27-20(16)28)24-8-15-14-5-6-29-18(14)4-3-17(15)22/h3-4,9-10H,5-6,8H2,1-2H3,(H,24,25) RMUQMIXHRVWFLW-UHFFFAOYSA-N 513784 US11091495, Example 145::US11220509, Example 145::US11485738, Example 145 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513784&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788171 459631014 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221578 Fc1ccc2OCCc2c1CNc1ncc(-c2ccccn2)c2nc(cn12)C#N InChI=1S/C21H15FN6O/c22-17-4-5-19-14(6-8-29-19)15(17)10-25-21-26-11-16(18-3-1-2-7-24-18)20-27-13(9-23)12-28(20)21/h1-5,7,11-12H,6,8,10H2,(H,25,26) PBCKVNVBAQVRBC-UHFFFAOYSA-N 513785 US11091495, Example 146::US11220509, Example 146::US11485738, Example 146 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513785&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788130 459631015 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221579 OCc1ccc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H17FN6O2/c23-19-3-4-20-16(5-6-31-20)18(19)10-27-22-26-9-17(13-1-2-14(12-30)25-8-13)21-28-15(7-24)11-29(21)22/h1-4,8-9,11,30H,5-6,10,12H2,(H,26,27) RELJOVYVSLYYAF-UHFFFAOYSA-N 513786 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(6-(hydroxymethyl)pyridin-3-yl)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 147::US11220509, Example 147::US11485738, Example 147 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513786&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139371653 459631016 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221580 OCc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H17FN6O2/c23-18-3-4-20-15(5-7-31-20)16(18)9-26-22-27-10-17(14-2-1-6-25-19(14)12-30)21-28-13(8-24)11-29(21)22/h1-4,6,10-11,30H,5,7,9,12H2,(H,26,27) GZNSVNWPLOOUOU-UHFFFAOYSA-N 513787 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(2-(hydroxymethyl)pyridin-3-yl)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 148::US11220509, Example 148::US11485738, Example 148 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513787&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139371559 459631017 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221581 CN(C)Cc1c(F)cc(cc1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H21F3N6O/c1-33(2)13-19-21(27)7-14(8-22(19)28)17-10-30-25(34-12-15(9-29)32-24(17)34)31-11-18-16-5-6-35-23(16)4-3-20(18)26/h3-4,7-8,10,12H,5-6,11,13H2,1-2H3,(H,30,31) ISXVDIQXEBGFIC-UHFFFAOYSA-N 513788 8-(4-((dimethylamino)methyl)-3,5-difluorophenyl)-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 149::US11220509, Example 149::US11485738, Example 149 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513788&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139370906 459631018 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221582 OC1CN(Cc2ccc(cc2)-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C#N)C1 InChI=1S/C26H23FN6O2/c27-23-5-6-24-20(7-8-35-24)22(23)11-30-26-29-10-21(25-31-18(9-28)13-33(25)26)17-3-1-16(2-4-17)12-32-14-19(34)15-32/h1-6,10,13,19,34H,7-8,11-12,14-15H2,(H,29,30) SNWGDJSKRNYDNU-UHFFFAOYSA-N 513789 US11091495, Example 150::US11220509, Example 150::US11485738, Example 150 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513789&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788145 459631019 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221583 OC1CCN(Cc2ccc(cc2)-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C#N)C1 InChI=1S/C27H25FN6O2/c28-24-5-6-25-21(8-10-36-25)23(24)13-31-27-30-12-22(26-32-19(11-29)15-34(26)27)18-3-1-17(2-4-18)14-33-9-7-20(35)16-33/h1-6,12,15,20,35H,7-10,13-14,16H2,(H,30,31) NZDQFKCTEQPZOT-UHFFFAOYSA-N 513790 US11091495, Example 151::US11220509, Example 151::US11485738, Example 151 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513790&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788162 459631020 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221584 CN(C)Cc1ccc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H24FN7O/c1-15-18(5-4-16(30-15)13-32(2)3)21-12-29-25(33-14-17(10-27)31-24(21)33)28-11-20-19-8-9-34-23(19)7-6-22(20)26/h4-7,12,14H,8-9,11,13H2,1-3H3,(H,28,29) KCWPHFCEOFZPQY-UHFFFAOYSA-N 513791 US11091495, Example 152::US11485738, Example 152 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513791&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788021 459631021 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221585 Fc1ccc2OCCc2c1CNc1ncc(-c2ccn(CC3CCCO3)n2)c2nc(cn12)C#N InChI=1S/C24H22FN7O2/c25-20-3-4-22-17(6-9-34-22)18(20)11-27-24-28-12-19(23-29-15(10-26)13-32(23)24)21-5-7-31(30-21)14-16-2-1-8-33-16/h3-5,7,12-13,16H,1-2,6,8-9,11,14H2,(H,27,28) PIRZDXQMMZIWOI-UHFFFAOYSA-N 533530 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(1-((tetrahydrofuran-2-yl)methyl)-1H-pyrazol-3-yl)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11220509, Example 153::US11485738, Example 153 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=533530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=533530&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221586 Fc1ccc2OCCc2c1CNc1ncc(-c2cnn(CC3CCOC3)c2)c2nc(cn12)C#N InChI=1S/C24H22FN7O2/c25-21-1-2-22-18(4-6-34-22)20(21)10-28-24-27-9-19(23-30-17(7-26)13-32(23)24)16-8-29-31(12-16)11-15-3-5-33-14-15/h1-2,8-9,12-13,15H,3-6,10-11,14H2,(H,27,28) AVAZTTCDLJIOJM-UHFFFAOYSA-N 513793 US11091495, Example 154::US11220509, Example 154::US11485738, Example 154 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513793&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787988 459631023 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221587 Cc1cc(-c2cnc(NCc3c4C(O)COc4ccc3F)n3cc(nc23)C#N)n(C)n1 InChI=1S/C21H18FN7O2/c1-11-5-16(28(2)27-11)14-8-25-21(29-9-12(6-23)26-20(14)29)24-7-13-15(22)3-4-18-19(13)17(30)10-31-18/h3-5,8-9,17,30H,7,10H2,1-2H3,(H,24,25) HFXKNOVSZHJOEP-UHFFFAOYSA-N 533532 8-(1,3-dimethyl-1H-pyrazol-5-yl)-5-(((5-fluoro-3-hydroxy-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11220509, Example 155::US11485738, Example 155 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=533532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=533532&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221588 Cn1cccc(-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C#N)c1=O InChI=1S/C22H17FN6O2/c1-28-7-2-3-15(21(28)30)17-11-26-22(29-12-13(9-24)27-20(17)29)25-10-16-14-6-8-31-19(14)5-4-18(16)23/h2-5,7,11-12H,6,8,10H2,1H3,(H,25,26) AMHPTWFBCSOPAZ-UHFFFAOYSA-N 513795 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(1-methyl-2-oxo-1,2-dihydropyridin-3-yl)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 156::US11485738, Example 156 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513795&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676965 459631025 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221589 Cn1nccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C20H16FN7O/c1-27-17(4-6-25-27)15-10-24-20(28-11-12(8-22)26-19(15)28)23-9-14-13-5-7-29-18(13)3-2-16(14)21/h2-4,6,10-11H,5,7,9H2,1H3,(H,23,24) ZBMIGKSBOCAYQM-UHFFFAOYSA-N 513753 US11091495, Example 114::US11091495, Example 157::US11220509, Example 157::US11485738, Example 157 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513753&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788092 459630983 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221590 COCCOc1ccc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C24H21FN6O3/c1-32-8-9-34-22-5-2-15(11-27-22)18-12-28-24(31-14-16(10-26)30-23(18)31)29-13-19-17-6-7-33-21(17)4-3-20(19)25/h2-5,11-12,14H,6-9,13H2,1H3,(H,28,29) QVPNALZXLPFBHR-UHFFFAOYSA-N 513797 US11091495, Example 158::US11220509, Example 158::US11485738, Example 158 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513797&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050997 459631026 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221591 CN1CCc2cc(ccc2C1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H23FN6O/c1-32-8-6-16-10-17(2-3-18(16)14-32)21-12-29-26(33-15-19(11-28)31-25(21)33)30-13-22-20-7-9-34-24(20)5-4-23(22)27/h2-5,10,12,15H,6-9,13-14H2,1H3,(H,29,30) BHPPGHQHTIQBCQ-UHFFFAOYSA-N 513798 US11091495, Example 159::US11220509, Example 159::US11485738, Example 159 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513798&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788086 459631027 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221592 CN1CCCC1c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C27H25FN6O/c1-33-11-2-3-24(33)18-6-4-17(5-7-18)21-14-30-27(34-16-19(13-29)32-26(21)34)31-15-22-20-10-12-35-25(20)9-8-23(22)28/h4-9,14,16,24H,2-3,10-12,15H2,1H3,(H,30,31) YJXSMBXBANRCDK-UHFFFAOYSA-N 513799 US11091495, Example 160::US11220509, Example 160::US11485738, Example 160 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513799&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787978 459631028 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221593 COCCOc1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H22FN5O3/c1-32-10-11-33-18-4-2-16(3-5-18)20-13-28-25(31-15-17(12-27)30-24(20)31)29-14-21-19-8-9-34-23(19)7-6-22(21)26/h2-7,13,15H,8-11,14H2,1H3,(H,28,29) MZXOMPJHIVKHRJ-UHFFFAOYSA-N 513800 US11091495, Example 161::US11220509, Example 161::US11485738, Example 161 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513800&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050906 459631029 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221594 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(cc2)C2CCCO2)c2nc(cn12)C#N InChI=1S/C26H22FN5O2/c27-22-7-8-24-19(9-11-34-24)21(22)14-30-26-29-13-20(25-31-18(12-28)15-32(25)26)16-3-5-17(6-4-16)23-2-1-10-33-23/h3-8,13,15,23H,1-2,9-11,14H2,(H,29,30) ULCAYNNEZLTPSJ-UHFFFAOYSA-N 513801 US11091495, Example 162::US11220509, Example 162::US11485738, Example 162 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513801&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788134 459631030 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221595 CN(C)CCc1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H25FN6O/c1-32(2)11-9-17-3-5-18(6-4-17)21-14-29-26(33-16-19(13-28)31-25(21)33)30-15-22-20-10-12-34-24(20)8-7-23(22)27/h3-8,14,16H,9-12,15H2,1-2H3,(H,29,30) UJORTQXRCVKJIH-UHFFFAOYSA-N 513802 US11091495, Example 163::US11220509, Example 163::US11485738, Example 163 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513802&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788074 459631031 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221596 CCOP(=O)(OCC)c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H25FN5O4P/c1-3-35-37(33,36-4-2)19-7-5-17(6-8-19)21-14-29-26(32-16-18(13-28)31-25(21)32)30-15-22-20-11-12-34-24(20)10-9-23(22)27/h5-10,14,16H,3-4,11-12,15H2,1-2H3,(H,29,30) ULCNMWAWQKJSNY-UHFFFAOYSA-N 513803 US11091495, Example 164::US11220509, Example 164::US11485738, Example 164 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513803&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050948 459631032 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221597 CN(C)Cc1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H23FN6O/c1-31(2)14-16-3-5-17(6-4-16)20-12-28-25(32-15-18(11-27)30-24(20)32)29-13-21-19-9-10-33-23(19)8-7-22(21)26/h3-8,12,15H,9-10,13-14H2,1-2H3,(H,28,29) JJCZYCVSGAQWBL-UHFFFAOYSA-N 513751 US11091495, Example 112::US11091495, Example 165::US11220509, Example 165::US11485738, Example 165 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513751&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788075 459630981 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221598 COC(=O)c1ccc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H17FN6O3/c1-32-22(31)19-4-2-13(9-26-19)16-10-27-23(30-12-14(8-25)29-21(16)30)28-11-17-15-6-7-33-20(15)5-3-18(17)24/h2-5,9-10,12H,6-7,11H2,1H3,(H,27,28) PDLWLOSONZIQQV-UHFFFAOYSA-N 513805 US11091495, Example 166::US11220509, Example 166::US11485738, Example 166 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513805&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788127 459631033 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221599 COC(=O)c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C24H18FN5O3/c1-32-23(31)15-4-2-14(3-5-15)18-11-27-24(30-13-16(10-26)29-22(18)30)28-12-19-17-8-9-33-21(17)7-6-20(19)25/h2-7,11,13H,8-9,12H2,1H3,(H,27,28) CKUPHBSZAYMVSP-UHFFFAOYSA-N 513806 US11091495, Example 167::US11220509, Example 167::US11485738, Example 167 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513806&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788122 459631034 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221600 CN1CCc2cc(ccc2C1=O)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H21FN6O2/c1-32-8-6-16-10-15(2-3-18(16)25(32)34)20-12-29-26(33-14-17(11-28)31-24(20)33)30-13-21-19-7-9-35-23(19)5-4-22(21)27/h2-5,10,12,14H,6-9,13H2,1H3,(H,29,30) BINKQLRJNWVEBR-UHFFFAOYSA-N 513807 US11091495, Example 168::US11220509, Example 168::US11485738, Example 168 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513807&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788065 459631035 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221601 COC(=O)c1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C#N)n(C)n1 InChI=1S/C22H18FN7O3/c1-29-18(7-17(28-29)21(31)32-2)15-10-26-22(30-11-12(8-24)27-20(15)30)25-9-14-13-5-6-33-19(13)4-3-16(14)23/h3-4,7,10-11H,5-6,9H2,1-2H3,(H,25,26) HTQKSDCXETZAJW-UHFFFAOYSA-N 580118 US11485738, Example 169 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580118&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156051113 475725975 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221602 CN(C)C(=O)c1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C#N)n(C)n1 InChI=1S/C23H21FN8O2/c1-30(2)22(33)18-8-19(31(3)29-18)16-11-27-23(32-12-13(9-25)28-21(16)32)26-10-15-14-6-7-34-20(14)5-4-17(15)24/h4-5,8,11-12H,6-7,10H2,1-3H3,(H,26,27) PWPLILAVZPAYIU-UHFFFAOYSA-N 513809 US11091495, Example 170::US11091495, Example 210::US11220509, Example 170::US11485738, Example 170 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513809&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676970 459631036 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221603 CN(C)C1(CC1)c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C27H25FN6O/c1-33(2)27(10-11-27)18-5-3-17(4-6-18)21-14-30-26(34-16-19(13-29)32-25(21)34)31-15-22-20-9-12-35-24(20)8-7-23(22)28/h3-8,14,16H,9-12,15H2,1-2H3,(H,30,31) NYJVWPDAWBYCFI-UHFFFAOYSA-N 513810 US11091495, Example 171::US11220509, Example 171::US11485738, Example 171 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513810&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788164 459631037 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221604 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc3C(=O)NCCc3c2)c2nc(cn12)C#N InChI=1S/C25H19FN6O2/c26-21-3-4-22-18(6-8-34-22)20(21)12-30-25-29-11-19(23-31-16(10-27)13-32(23)25)14-1-2-17-15(9-14)5-7-28-24(17)33/h1-4,9,11,13H,5-8,12H2,(H,28,33)(H,29,30) DDNCZCQKZAMSHN-UHFFFAOYSA-N 513811 US11091495, Example 172::US11220509, Example 172::US11485738, Example 172 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513811&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156051055 459631038 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221605 CN(C)Cc1ccc(c(C)c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H25FN6O/c1-16-10-17(14-32(2)3)4-5-19(16)22-13-30-26(33-15-18(11-28)31-25(22)33)29-12-21-20-8-9-34-24(20)7-6-23(21)27/h4-7,10,13,15H,8-9,12,14H2,1-3H3,(H,29,30) FLCIOLFIDGTRCI-UHFFFAOYSA-N 513671 US11091495, Example 173::US11091495, Example 202::US11091495, Example 223::US11091495, Example 32::US11220509, Example 223::US11485738, Example 223 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513671&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 9JL 7SI4 155788096 459630903 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221606 OC(=O)c1cccc(c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H16FN5O3/c24-19-4-5-20-16(6-7-32-20)18(19)11-27-23-26-10-17(21-28-15(9-25)12-29(21)23)13-2-1-3-14(8-13)22(30)31/h1-5,8,10,12H,6-7,11H2,(H,26,27)(H,30,31) YKIGHQQQYYRANS-UHFFFAOYSA-N 513813 US11091495, Example 174::US11220509, Example 174::US11485738, Example 174 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513813&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787984 459631039 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221607 Cc1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H18FN5O/c1-14-2-4-15(5-3-14)18-11-26-23(29-13-16(10-25)28-22(18)29)27-12-19-17-8-9-30-21(17)7-6-20(19)24/h2-7,11,13H,8-9,12H2,1H3,(H,26,27) SMOGNKYOJRPLBS-UHFFFAOYSA-N 513814 US11091495, Example 175::US11220509, Example 175::US11485738, Example 175 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513814&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788084 459631040 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221608 Cc1c(cccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N)C#N InChI=1S/C24H17FN6O/c1-14-15(9-26)3-2-4-17(14)20-12-29-24(31-13-16(10-27)30-23(20)31)28-11-19-18-7-8-32-22(18)6-5-21(19)25/h2-6,12-13H,7-8,11H2,1H3,(H,28,29) RJZWPKDRILLWOY-UHFFFAOYSA-N 513815 US11091495, Example 176::US11220509, Example 176::US11485738, Example 176 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513815&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788046 459631041 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221609 Cc1ccc(cc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N)C#N InChI=1S/C24H17FN6O/c1-14-2-3-15(9-26)8-18(14)20-12-29-24(31-13-16(10-27)30-23(20)31)28-11-19-17-6-7-32-22(17)5-4-21(19)25/h2-5,8,12-13H,6-7,11H2,1H3,(H,28,29) ZIPIJERVXUXJAA-UHFFFAOYSA-N 513816 US11091495, Example 177::US11220509, Example 177::US11485738, Example 177 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513816&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788166 459631042 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221610 Cc1cc(ccn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H17FN6O/c1-13-8-14(4-6-25-13)17-10-26-22(29-12-15(9-24)28-21(17)29)27-11-18-16-5-7-30-20(16)3-2-19(18)23/h2-4,6,8,10,12H,5,7,11H2,1H3,(H,26,27) BPXKZPSUOJQKKP-UHFFFAOYSA-N 513817 US11091495, Example 178::US11220509, Example 178::US11485738, Example 178 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513817&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787992 459631043 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221611 CC(O)Cn1cc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H20FN7O2/c1-13(31)10-29-11-14(7-27-29)17-8-25-22(30-12-15(6-24)28-21(17)30)26-9-18-16-4-5-32-20(16)3-2-19(18)23/h2-3,7-8,11-13,31H,4-5,9-10H2,1H3,(H,25,26) ZTFMSQSTAHJAPT-UHFFFAOYSA-N 513818 US11091495, Example 179::US11220509, Example 179::US11485738, Example 179 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513818&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788150 459631044 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221612 CN(C)C(=O)c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H21FN6O2/c1-31(2)24(33)16-5-3-15(4-6-16)19-12-28-25(32-14-17(11-27)30-23(19)32)29-13-20-18-9-10-34-22(18)8-7-21(20)26/h3-8,12,14H,9-10,13H2,1-2H3,(H,28,29) ZTQVUCDWYFVGNX-UHFFFAOYSA-N 513819 US11091495, Example 180::US11220509, Example 180::US11485738, Example 180 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513819&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787974 459631045 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221613 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(cc2)C(=O)N2CCOCC2)c2nc(cn12)C#N InChI=1S/C27H23FN6O3/c28-23-5-6-24-20(7-10-37-24)22(23)15-31-27-30-14-21(25-32-19(13-29)16-34(25)27)17-1-3-18(4-2-17)26(35)33-8-11-36-12-9-33/h1-6,14,16H,7-12,15H2,(H,30,31) FOEZFMSDBMCFGR-UHFFFAOYSA-N 513820 US11091495, Example 181::US11220509, Example 181::US11485738, Example 181 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513820&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788135 459631046 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221614 OCCn1cc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C21H18FN7O2/c22-18-1-2-19-15(3-6-31-19)17(18)10-25-21-24-9-16(13-8-26-28(11-13)4-5-30)20-27-14(7-23)12-29(20)21/h1-2,8-9,11-12,30H,3-6,10H2,(H,24,25) FWRKPJUHHIDPEE-UHFFFAOYSA-N 513821 US11091495, Example 182::US11220509, Example 182::US11485738, Example 182 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513821&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788179 459631047 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221615 OC(=O)c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H16FN5O3/c24-19-5-6-20-16(7-8-32-20)18(19)11-27-23-26-10-17(21-28-15(9-25)12-29(21)23)13-1-3-14(4-2-13)22(30)31/h1-6,10,12H,7-8,11H2,(H,26,27)(H,30,31) HBWVNXDFUHMOHQ-UHFFFAOYSA-N 513822 US11091495, Example 183::US11220509, Example 183::US11485738, Example 183 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513822&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788112 459631048 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221616 Cc1cc(ccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N)S(=O)(=O)C(F)(F)F InChI=1S/C24H17F4N5O3S/c1-13-8-15(37(34,35)24(26,27)28)2-3-16(13)19-11-31-23(33-12-14(9-29)32-22(19)33)30-10-18-17-6-7-36-21(17)5-4-20(18)25/h2-5,8,11-12H,6-7,10H2,1H3,(H,30,31) YAGRWOSMKWMLKY-UHFFFAOYSA-N 513823 US11091495, Example 184::US11220509, Example 184::US11485738, Example 184 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513823&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156051050 459631049 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221617 CNCc1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C24H21FN6O/c1-27-11-15-2-4-16(5-3-15)19-12-28-24(31-14-17(10-26)30-23(19)31)29-13-20-18-8-9-32-22(18)7-6-21(20)25/h2-7,12,14,27H,8-9,11,13H2,1H3,(H,28,29) JHUCGHRPGVOVCF-UHFFFAOYSA-N 513824 US11091495, Example 185::US11220509, Example 185::US11485738, Example 185 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513824&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787993 459631050 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221618 CNC(=O)c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C24H19FN6O2/c1-27-23(32)15-4-2-14(3-5-15)18-11-28-24(31-13-16(10-26)30-22(18)31)29-12-19-17-8-9-33-21(17)7-6-20(19)25/h2-7,11,13H,8-9,12H2,1H3,(H,27,32)(H,28,29) SGPQSSIOHDGUMV-UHFFFAOYSA-N 513825 US11091495, Example 186::US11220509, Example 186::US11485738, Example 186 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513825&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788088 459631051 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221619 Fc1ccc2OCCc2c1CNc1ncc(-c2ccccc2C#N)c2nc(cn12)C#N InChI=1S/C23H15FN6O/c24-20-5-6-21-17(7-8-31-21)18(20)11-27-23-28-12-19(16-4-2-1-3-14(16)9-25)22-29-15(10-26)13-30(22)23/h1-6,12-13H,7-8,11H2,(H,27,28) TWYPHVCCCUCUHQ-UHFFFAOYSA-N 513826 US11091495, Example 187::US11220509, Example 187::US11485738, Example 187 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513826&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050989 459631052 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221620 Fc1ccc2OCCc2c1CNc1ncc(-c2ccnc(c2)C#N)c2nc(cn12)C#N InChI=1S/C22H14FN7O/c23-19-1-2-20-16(4-6-31-20)18(19)11-28-22-27-10-17(13-3-5-26-14(7-13)8-24)21-29-15(9-25)12-30(21)22/h1-3,5,7,10,12H,4,6,11H2,(H,27,28) YPCJINHFCMZDAQ-UHFFFAOYSA-N 513827 US11091495, Example 188::US11220509, Example 188::US11485738, Example 188 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513827&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050944 459631053 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221621 CN(C)CCOc1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H25FN6O2/c1-32(2)10-12-34-19-5-3-17(4-6-19)21-14-29-26(33-16-18(13-28)31-25(21)33)30-15-22-20-9-11-35-24(20)8-7-23(22)27/h3-8,14,16H,9-12,15H2,1-2H3,(H,29,30) DAMMYUAOYACXNW-UHFFFAOYSA-N 513828 US11091495, Example 189::US11220509, Example 189::US11485738, Example 189 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513828&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788007 459631054 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221622 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(cc2)-c2nnn[nH]2)c2nc(cn12)C#N InChI=1S/C23H16FN9O/c24-19-5-6-20-16(7-8-34-20)18(19)11-27-23-26-10-17(22-28-15(9-25)12-33(22)23)13-1-3-14(4-2-13)21-29-31-32-30-21/h1-6,10,12H,7-8,11H2,(H,26,27)(H,29,30,31,32) NOEDLQUQVUAEQW-UHFFFAOYSA-N 513829 US11091495, Example 190::US11220509, Example 190::US11485738, Example 190 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513829&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 162533921 459631055 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221623 COCCOc1ncc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H20FN7O3/c1-32-6-7-34-23-28-9-14(10-29-23)17-11-26-22(31-13-15(8-25)30-21(17)31)27-12-18-16-4-5-33-20(16)3-2-19(18)24/h2-3,9-11,13H,4-7,12H2,1H3,(H,26,27) ISBXAPRIQWXGCC-UHFFFAOYSA-N 513830 US11091495, Example 191::US11220509, Example 191::US11485738, Example 191 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513830&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050911 459631056 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221624 Cc1ccc(c(C)c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C24H20FN5O/c1-14-3-4-17(15(2)9-14)20-12-28-24(30-13-16(10-26)29-23(20)30)27-11-19-18-7-8-31-22(18)6-5-21(19)25/h3-6,9,12-13H,7-8,11H2,1-2H3,(H,27,28) WGCZJLCYUXTCMO-UHFFFAOYSA-N 513831 US11091495, Example 192::US11220509, Example 192::US11485738, Example 192 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 >500 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513831&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788111 459631057 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221625 Fc1ccc2OCCc2c1CNc1ncc(-c2ccnn2C2CC2)c2nc(cn12)C#N InChI=1S/C22H18FN7O/c23-18-3-4-20-15(6-8-31-20)16(18)10-25-22-26-11-17(21-28-13(9-24)12-29(21)22)19-5-7-27-30(19)14-1-2-14/h3-5,7,11-12,14H,1-2,6,8,10H2,(H,25,26) DOUGAHKQRQYSPU-UHFFFAOYSA-N 513832 US11091495, Example 193::US11220509, Example 193::US11485738, Example 193 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513832&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788036 459631058 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221626 Cn1nccc(-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C#N)c1=O InChI=1S/C21H16FN7O2/c1-28-20(30)14(4-6-26-28)16-10-25-21(29-11-12(8-23)27-19(16)29)24-9-15-13-5-7-31-18(13)3-2-17(15)22/h2-4,6,10-11H,5,7,9H2,1H3,(H,24,25) RYCSQEVYKFGMDL-UHFFFAOYSA-N 513833 US11091495, Example 194::US11220509, Example 194::US11485738, Example 194 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513833&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787969 459631059 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221627 CN(C)Cc1cc(C)c(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H24FN7O/c1-15-8-16(13-32(2)3)28-10-19(15)21-12-30-25(33-14-17(9-27)31-24(21)33)29-11-20-18-6-7-34-23(18)5-4-22(20)26/h4-5,8,10,12,14H,6-7,11,13H2,1-3H3,(H,29,30) SMRSWCZPPVSVRD-UHFFFAOYSA-N 513834 US11091495, Example 195::US11220509, Example 195::US11485738, Example 195 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513834&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788137 459631060 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221628 CNCc1ccc(c(C)c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H23FN6O/c1-15-9-16(11-28-2)3-4-18(15)21-13-30-25(32-14-17(10-27)31-24(21)32)29-12-20-19-7-8-33-23(19)6-5-22(20)26/h3-6,9,13-14,28H,7-8,11-12H2,1-2H3,(H,29,30) ZMBBZQDNQSEFTN-UHFFFAOYSA-N 513835 US11091495, Example 196::US11220509, Example 196::US11485738, Example 196 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513835&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788147 459631061 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221629 CNCc1ccc(cc1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C24H20F2N6O/c1-28-10-15-3-2-14(8-21(15)26)18-11-29-24(32-13-16(9-27)31-23(18)32)30-12-19-17-6-7-33-22(17)5-4-20(19)25/h2-5,8,11,13,28H,6-7,10,12H2,1H3,(H,29,30) QCDMRDAMBIABOE-UHFFFAOYSA-N 513836 US11091495, Example 197::US11220509, Example 197::US11485738, Example 197 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513836&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788125 459631062 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221630 CN(C)Cc1ccc(c(c1)C#N)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H22FN7O/c1-33(2)14-16-3-4-19(17(9-16)10-28)22-13-31-26(34-15-18(11-29)32-25(22)34)30-12-21-20-7-8-35-24(20)6-5-23(21)27/h3-6,9,13,15H,7-8,12,14H2,1-2H3,(H,30,31) DFFPAXCRFUBMOA-UHFFFAOYSA-N 513837 US11091495, Example 198::US11220509, Example 198::US11485738, Example 198 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513837&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050962 459631063 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221631 CC(N(C)C)c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H25FN6O/c1-16(32(2)3)17-4-6-18(7-5-17)21-13-29-26(33-15-19(12-28)31-25(21)33)30-14-22-20-10-11-34-24(20)9-8-23(22)27/h4-9,13,15-16H,10-11,14H2,1-3H3,(H,29,30) CQYOZUOGBAKLPI-UHFFFAOYSA-N 513838 US11091495, Example 199::US11220509, Example 199::US11485738, Example 199 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513838&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155787987 459631064 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221632 CN(C)Cc1ccc(cc1C)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H25FN6O/c1-16-10-17(4-5-18(16)14-32(2)3)21-12-29-26(33-15-19(11-28)31-25(21)33)30-13-22-20-8-9-34-24(20)7-6-23(22)27/h4-7,10,12,15H,8-9,13-14H2,1-3H3,(H,29,30) HXQLCERFGIVZMJ-UHFFFAOYSA-N 513839 US11091495, Example 200::US11220509, Example 200::US11485738, Example 200 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513839&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788113 459631065 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221633 CN(C)Cc1ccc(cc1C#N)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H22FN7O/c1-33(2)14-17-4-3-16(9-18(17)10-28)21-12-30-26(34-15-19(11-29)32-25(21)34)31-13-22-20-7-8-35-24(20)6-5-23(22)27/h3-6,9,12,15H,7-8,13-14H2,1-2H3,(H,30,31) CZAAZRXLUIBAEL-UHFFFAOYSA-N 513840 US11091495, Example 201::US11220509, Example 201::US11485738, Example 201 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513840&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050905 459631066 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221634 CN(C)Cc1ccc(c(C)c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H25FN6O/c1-16-10-17(14-32(2)3)4-5-19(16)22-13-30-26(33-15-18(11-28)31-25(22)33)29-12-21-20-8-9-34-24(20)7-6-23(21)27/h4-7,10,13,15H,8-9,12,14H2,1-3H3,(H,29,30) FLCIOLFIDGTRCI-UHFFFAOYSA-N 513671 US11091495, Example 173::US11091495, Example 202::US11091495, Example 223::US11091495, Example 32::US11220509, Example 223::US11485738, Example 223 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513671&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 9JL 7SI4 155788096 459630903 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221635 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc3CNCCc3c2)c2nc(cn12)C#N InChI=1S/C25H21FN6O/c26-22-3-4-23-19(6-8-33-23)21(22)13-30-25-29-12-20(24-31-18(10-27)14-32(24)25)16-1-2-17-11-28-7-5-15(17)9-16/h1-4,9,12,14,28H,5-8,11,13H2,(H,29,30) WVAWYXLXRBQNHE-UHFFFAOYSA-N 513842 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(1,2,3,4-tetrahydroisoquinolin-6-yl)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 203::US11220509, Example 203::US11485738, Example 203 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513842&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 152329158 459631067 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221636 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(cc2)C2CCCN2)c2nc(cn12)C#N InChI=1S/C26H23FN6O/c27-22-7-8-24-19(9-11-34-24)21(22)14-31-26-30-13-20(25-32-18(12-28)15-33(25)26)16-3-5-17(6-4-16)23-2-1-10-29-23/h3-8,13,15,23,29H,1-2,9-11,14H2,(H,30,31) QFQOFKFJTAQQHV-UHFFFAOYSA-N 513843 US11091495, Example 204::US11220509, Example 204::US11485738, Example 204 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513843&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788129 459631068 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221637 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc3CNCc3c2)c2nc(cn12)C#N InChI=1S/C24H19FN6O/c25-21-3-4-22-18(5-6-32-22)20(21)12-29-24-28-11-19(23-30-17(8-26)13-31(23)24)14-1-2-15-9-27-10-16(15)7-14/h1-4,7,11,13,27H,5-6,9-10,12H2,(H,28,29) WCMWUOKIGJJBEW-UHFFFAOYSA-N 513844 US11091495, Example 205::US11220509, Example 205::US11485738, Example 205 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513844&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788050 459631069 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221638 COCCOc1ccc(c(C)c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H24FN5O3/c1-16-11-18(34-10-9-33-2)3-4-19(16)22-14-30-26(32-15-17(12-28)31-25(22)32)29-13-21-20-7-8-35-24(20)6-5-23(21)27/h3-6,11,14-15H,7-10,13H2,1-2H3,(H,29,30) DUXYHMYBFJIRAW-UHFFFAOYSA-N 513845 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(4-(2-methoxyethoxy)-2-methylphenyl)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 206::US11220509, Example 206::US11485738, Example 206 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513845&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139371008 459631070 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221639 CN(C)Cc1ccc(c(C)c1)-c1cnc(NCc2c3C(O)COc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H25FN6O2/c1-15-8-16(12-32(2)3)4-5-18(15)19-10-29-26(33-13-17(9-28)31-25(19)33)30-11-20-21(27)6-7-23-24(20)22(34)14-35-23/h4-8,10,13,22,34H,11-12,14H2,1-3H3,(H,29,30) MIACXTOAOOEYRF-UHFFFAOYSA-N 513846 8-(4-((dimethylamino)methyl)-2-methylphenyl)-5-(((5-fluoro-3-hydroxy-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 207::US11220509, Example 207::US11485738, Example 207 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513846&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676910 459631071 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221640 CNC(=O)c1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C#N)n(C)n1 InChI=1S/C22H19FN8O2/c1-25-21(32)17-7-18(30(2)29-17)15-10-27-22(31-11-12(8-24)28-20(15)31)26-9-14-13-5-6-33-19(13)4-3-16(14)23/h3-4,7,10-11H,5-6,9H2,1-2H3,(H,25,32)(H,26,27) PUUDAUWNSZGWMD-UHFFFAOYSA-N 513847 5-(2-cyano-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,2-c]pyrimidin-8-yl)-N,1-dimethyl-1H-pyrazole-3-carboxamide::US11091495, Example 208::US11091495, Example 211::US11220509, Example 208::US11485738, Example 208 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513847&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676987 459631072 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221641 CN(C)Cc1ccc(cc1C)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H25FN6O/c1-16-10-17(4-5-18(16)14-32(2)3)21-12-29-26(33-15-19(11-28)31-25(21)33)30-13-22-20-8-9-34-24(20)7-6-23(22)27/h4-7,10,12,15H,8-9,13-14H2,1-3H3,(H,29,30) HXQLCERFGIVZMJ-UHFFFAOYSA-N 513839 US11091495, Example 200::US11220509, Example 200::US11485738, Example 200 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513839&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788113 459631065 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221642 CN(C)Cc1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C#N)n(C)n1 InChI=1S/C23H23FN8O/c1-30(2)12-14-8-20(31(3)29-14)18-11-27-23(32-13-15(9-25)28-22(18)32)26-10-17-16-6-7-33-21(16)5-4-19(17)24/h4-5,8,11,13H,6-7,10,12H2,1-3H3,(H,26,27) WDAFAPSQJVMAAM-UHFFFAOYSA-N 580325 8-(3-((dimethylamino)methyl)-1-methyl-1H-pyrazol-5-yl)-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11485738, Example 210 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580325&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676982 475726179 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221643 CNCc1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C#N)n(C)n1 InChI=1S/C22H21FN8O/c1-25-9-13-7-19(30(2)29-13)17-11-27-22(31-12-14(8-24)28-21(17)31)26-10-16-15-5-6-32-20(15)4-3-18(16)23/h3-4,7,11-12,25H,5-6,9-10H2,1-2H3,(H,26,27) JQESEJAYPJNATJ-UHFFFAOYSA-N 580326 5-(((5-fluoro-2, 3-dihydrobenzofuran-4-yl)methyl)amino)-8-(1-methyl-3-((methylamino)methyl)-1H-pyrazol-5-yl)imidazo[1, 2-c]pyrimidine-2-carbonitrile::US11485738, Example 211 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580326&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676912 475726180 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221644 Cn1nc(cc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N)C#N InChI=1S/C21H15FN8O/c1-29-18(6-12(7-23)28-29)16-10-26-21(30-11-13(8-24)27-20(16)30)25-9-15-14-4-5-31-19(14)3-2-17(15)22/h2-3,6,10-11H,4-5,9H2,1H3,(H,25,26) KHCUUJBQMHEFFX-UHFFFAOYSA-N 513850 8-(3-cyano-1-methyl-1H-pyrazol-5-yl)-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 212::US11220509, Example 212::US11485738, Example 212 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513850&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139371713 459631073 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221645 Cc1cc(ccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N)[C@@H]1CCCN1 InChI=1S/C27H25FN6O/c1-16-11-17(24-3-2-9-30-24)4-5-19(16)22-14-32-27(34-15-18(12-29)33-26(22)34)31-13-21-20-8-10-35-25(20)7-6-23(21)28/h4-7,11,14-15,24,30H,2-3,8-10,13H2,1H3,(H,31,32)/t24-/m0/s1 QKETUAWXXUWCHE-DEOSSOPVSA-N 513851 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(2-methyl-4-(pyrrolidin-2-yl)phenyl)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 213::US11485738, Example 213 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513851&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050907 459631074 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221646 Cc1cc(ccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N)[C@H]1CCCN1 InChI=1S/C27H25FN6O/c1-16-11-17(24-3-2-9-30-24)4-5-19(16)22-14-32-27(34-15-18(12-29)33-26(22)34)31-13-21-20-8-10-35-25(20)7-6-23(21)28/h4-7,11,14-15,24,30H,2-3,8-10,13H2,1H3,(H,31,32)/t24-/m1/s1 QKETUAWXXUWCHE-XMMPIXPASA-N 513852 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(2-methyl-4-(pyrrolidin-2-yl)phenyl)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 214::US11485738, Example 214 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513852&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156051058 459631075 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221647 OC(=O)c1ccc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C22H15FN6O3/c23-17-2-4-19-14(5-6-32-19)16(17)10-27-22-26-9-15(20-28-13(7-24)11-29(20)22)12-1-3-18(21(30)31)25-8-12/h1-4,8-9,11H,5-6,10H2,(H,26,27)(H,30,31) VMPDLFKFCKRYRQ-UHFFFAOYSA-N 513853 5-(2-cyano-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,2-c]pyrimidin-8-yl)picolinic acid::US11091495, Example 215::US11220509, Example 215::US11485738, Example 215 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513853&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676938 459631076 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221648 CN(C)Cc1ncc(cn1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H21FN8O/c1-31(2)13-21-26-8-14(9-27-21)17-10-28-23(32-12-15(7-25)30-22(17)32)29-11-18-16-5-6-33-20(16)4-3-19(18)24/h3-4,8-10,12H,5-6,11,13H2,1-2H3,(H,28,29) OGGJAWYOWLHRHX-UHFFFAOYSA-N 513854 8-(2-((dimethylamino)methyl)pyrimidin-5-yl)-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 216::US11220509, Example 216::US11485738, Example 216 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513854&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139371000 459631077 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221649 CN(C)CCc1cccc(c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H25FN6O/c1-32(2)10-8-17-4-3-5-18(12-17)21-14-29-26(33-16-19(13-28)31-25(21)33)30-15-22-20-9-11-34-24(20)7-6-23(22)27/h3-7,12,14,16H,8-11,15H2,1-2H3,(H,29,30) FJGUSPHJPZYYAJ-UHFFFAOYSA-N 513855 8-(3-(2-(dimethylamino)ethyl)phenyl)-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 217::US11220509, Example 217::US11485738, Example 217 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513855&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139370710 459631078 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221650 Fc1ccc2OCCc2c1CNc1ncc(-c2cc[nH]c(=O)c2)c2nc(cn12)C#N InChI=1S/C21H15FN6O2/c22-17-1-2-18-14(4-6-30-18)16(17)10-26-21-25-9-15(12-3-5-24-19(29)7-12)20-27-13(8-23)11-28(20)21/h1-3,5,7,9,11H,4,6,10H2,(H,24,29)(H,25,26) JIBDHSHJRVFEIW-UHFFFAOYSA-N 580333 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(2-oxo-1,2-dihydropyridin-4-yl)imidazo[1, 2-c]pyrimidine-2-carbonitrile::US11485738, Example 218 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=580333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=580333&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 166594412 475726187 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221651 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(cc2)[C@@H]2CCCN2)c2nc(cn12)C#N InChI=1S/C26H23FN6O/c27-22-7-8-24-19(9-11-34-24)21(22)14-31-26-30-13-20(25-32-18(12-28)15-33(25)26)16-3-5-17(6-4-16)23-2-1-10-29-23/h3-8,13,15,23,29H,1-2,9-11,14H2,(H,30,31)/t23-/m0/s1 QFQOFKFJTAQQHV-QHCPKHFHSA-N 513857 US11091495, Example 219::US11220509, Example 219::US11485738, Example 219 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513857&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788156 459631079 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221652 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(cc2)[C@H]2CCCN2)c2nc(cn12)C#N InChI=1S/C26H23FN6O/c27-22-7-8-24-19(9-11-34-24)21(22)14-31-26-30-13-20(25-32-18(12-28)15-33(25)26)16-3-5-17(6-4-16)23-2-1-10-29-23/h3-8,13,15,23,29H,1-2,9-11,14H2,(H,30,31)/t23-/m1/s1 QFQOFKFJTAQQHV-HSZRJFAPSA-N 513858 US11091495, Example 220::US11220509, Example 220::US11485738, Example 220 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513858&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788055 459631080 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221653 CN1CCC1c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H23FN6O/c1-32-10-8-23(32)17-4-2-16(3-5-17)20-13-29-26(33-15-18(12-28)31-25(20)33)30-14-21-19-9-11-34-24(19)7-6-22(21)27/h2-7,13,15,23H,8-11,14H2,1H3,(H,29,30) BVFSKJWAVRMYSH-UHFFFAOYSA-N 513859 US11091495, Example 221::US11220509, Example 221::US11485738, Example 221 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513859&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788157 459631081 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221654 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(cc2)C2CC(=O)N2)c2nc(cn12)C#N InChI=1S/C25H19FN6O2/c26-20-5-6-22-17(7-8-34-22)19(20)12-29-25-28-11-18(24-30-16(10-27)13-32(24)25)14-1-3-15(4-2-14)21-9-23(33)31-21/h1-6,11,13,21H,7-9,12H2,(H,28,29)(H,31,33) DYDXHJYZMKNYFZ-UHFFFAOYSA-N 513860 US11091495, Example 222::US11220509, Example 222::US11485738, Example 222 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513860&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788016 459631082 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221655 CN(C)Cc1ccc(c(C)c1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C26H25FN6O/c1-16-10-17(14-32(2)3)4-5-19(16)22-13-30-26(33-15-18(11-28)31-25(22)33)29-12-21-20-8-9-34-24(20)7-6-23(21)27/h4-7,10,13,15H,8-9,12,14H2,1-3H3,(H,29,30) FLCIOLFIDGTRCI-UHFFFAOYSA-N 513671 US11091495, Example 173::US11091495, Example 202::US11091495, Example 223::US11091495, Example 32::US11220509, Example 223::US11485738, Example 223 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513671&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 9JL 7SI4 155788096 459630903 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221656 Cn1cc(c(n1)C#N)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C21H15FN8O/c1-29-11-16(18(7-24)28-29)15-9-26-21(30-10-12(6-23)27-20(15)30)25-8-14-13-4-5-31-19(13)3-2-17(14)22/h2-3,9-11H,4-5,8H2,1H3,(H,25,26) DAVDIQRPWGWPFS-UHFFFAOYSA-N 513862 US11091495, Example 224::US11220509, Example 224::US11485738, Example 224 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513862&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 156050909 459631083 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221657 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(cc2)C2COCCN2)c2nc(cn12)C#N InChI=1S/C26H23FN6O2/c27-22-5-6-24-19(7-9-35-24)21(22)13-31-26-30-12-20(25-32-18(11-28)14-33(25)26)16-1-3-17(4-2-16)23-15-34-10-8-29-23/h1-6,12,14,23,29H,7-10,13,15H2,(H,30,31) RQXKTZWMEAIRMB-UHFFFAOYSA-N 513863 US11091495, Example 225::US11220509, Example 225::US11485738, Example 225 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513863&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788146 459631084 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221658 Fc1ccc2OCCc2c1CNc1ncc(-c2ccc(cc2)C2CCN2)c2nc(cn12)C#N InChI=1S/C25H21FN6O/c26-21-5-6-23-18(8-10-33-23)20(21)13-30-25-29-12-19(24-31-17(11-27)14-32(24)25)15-1-3-16(4-2-15)22-7-9-28-22/h1-6,12,14,22,28H,7-10,13H2,(H,29,30) NOAQOCXJZMJAMC-UHFFFAOYSA-N 513864 US11091495, Example 226::US11220509, Example 226::US11485738, Example 226 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513864&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788144 459631085 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221659 CN1CCOCC1c1ccc(cc1)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C27H25FN6O2/c1-33-9-11-35-16-24(33)18-4-2-17(3-5-18)21-13-30-27(34-15-19(12-29)32-26(21)34)31-14-22-20-8-10-36-25(20)7-6-23(22)28/h2-7,13,15,24H,8-11,14,16H2,1H3,(H,30,31) GHGXGLCWQKLORM-UHFFFAOYSA-N 513865 US11091495, Example 227::US11220509, Example 227::US11485738, Example 227 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513865&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155788115 459631086 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221660 Cc1cc(-c2cnc(NCc3c4OCOc4ccc3F)n3cc(nc23)C#N)n(C)n1 InChI=1S/C20H16FN7O2/c1-11-5-16(27(2)26-11)14-8-24-20(28-9-12(6-22)25-19(14)28)23-7-13-15(21)3-4-17-18(13)30-10-29-17/h3-5,8-9H,7,10H2,1-2H3,(H,23,24) FOBKSISMMONNAI-UHFFFAOYSA-N 533604 US11220509, Example 228::US11485738, Example 228 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=533604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=533604&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221661 CN1CCN(CC1)C(=O)c1cc(-c2cnc(NCc3c4CCOc4ccc3F)n3cc(nc23)C#N)n(C)n1 InChI=1S/C26H26FN9O2/c1-33-6-8-35(9-7-33)25(37)21-11-22(34(2)32-21)19-14-30-26(36-15-16(12-28)31-24(19)36)29-13-18-17-5-10-38-23(17)4-3-20(18)27/h3-4,11,14-15H,5-10,13H2,1-2H3,(H,29,30) JTCGIKFKCGLAPJ-UHFFFAOYSA-N 513867 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(1-methyl-3-(4-methylpiperazine-1-carbonyl)-1H-pyrazol-5-yl)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 229::US11220509, Example 229::US11485738, Example 229 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513867&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676915 459631087 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221662 CN(C)CCn1nccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C23H23FN8O/c1-30(2)8-9-32-20(5-7-28-32)18-13-27-23(31-14-15(11-25)29-22(18)31)26-12-17-16-6-10-33-21(16)4-3-19(17)24/h3-5,7,13-14H,6,8-10,12H2,1-2H3,(H,26,27) PYPNAVIDPGTVCP-UHFFFAOYSA-N 513868 8-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-5-yl)-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 230::US11485738, Example 230 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513868&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139371722 459631088 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221663 OCCn1nccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C21H18FN7O2/c22-17-1-2-19-14(4-8-31-19)15(17)10-24-21-25-11-16(18-3-5-26-29(18)6-7-30)20-27-13(9-23)12-28(20)21/h1-3,5,11-12,30H,4,6-8,10H2,(H,24,25) FEBQMVADONDCSH-UHFFFAOYSA-N 513869 5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-8-(1-(2-hydroxyethyl)-1H-pyrazol-5-yl)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 231::US11220509, Example 231::US11485738, Example 231 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513869&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139371093 459631089 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221664 Fc1ccc2OCCc2c1CNc1ncc(-c2n[nH]cc2Br)c2nc(cn12)C#N InChI=1S/C19H13BrFN7O/c20-14-8-25-27-17(14)13-7-24-19(28-9-10(5-22)26-18(13)28)23-6-12-11-3-4-29-16(11)2-1-15(12)21/h1-2,7-9H,3-4,6H2,(H,23,24)(H,25,27) QJOCJQZOHIWCTD-UHFFFAOYSA-N 513870 8-(4-bromo-1H-pyrazol-3-yl)-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 232::US11220509, Example 232::US11485738, Example 232 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 300 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513870&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 139371710 459631090 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9 1221665 CN(C)Cc1ncc(c(C)c1F)-c1cnc(NCc2c3CCOc3ccc2F)n2cc(nc12)C#N InChI=1S/C25H23F2N7O/c1-14-17(9-29-21(23(14)27)13-33(2)3)19-11-31-25(34-12-15(8-28)32-24(19)34)30-10-18-16-6-7-35-22(16)5-4-20(18)26/h4-5,9,11-12H,6-7,10,13H2,1-3H3,(H,30,31) XMQRHCDCYAICKZ-UHFFFAOYSA-N 513871 8-(6-((dimethylamino)methyl)-5-fluoro-4-methylpyridin-3-yl)-5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)imidazo[1,2-c]pyrimidine-2-carbonitrile::US11091495, Example 233::US11220509, Example 233::US11485738, Example 233 Histone-binding protein RBBP4/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2 <100 US Patent 10.7270/Q2HQ43R4 aid1806967 US11485738 Marx, MA; Lee, MR; Bobinski, TP; Burns, AC; Arora, N; Christensen, JG; Ketcham, JM MIRATI THERAPEUTICS, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=513871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=302&target=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=513871&enzyme=Histone-binding+protein+RBBP4%2FPolycomb+protein+EED%2FPolycomb+protein+SUZ12%2FZinc+finger+protein+AEBP2&column=ki&startPg=0&Increment=50&submit=Search 155676957 459631091 4 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 2QXV,3IIW,3JPX,3JZG,3JZH,3JZN,3K26,3K27,4W2R,4X3E,5GSA,5H14,5H15,5H17,5H19,5H24,5H25,5HYN,5IJ7,5IJ8,5K0M,5LS6,5TTW,5U5H,5U5K,5U5T,5U62,5U69,5U6D,5U8A,5U8F,5WG6,5WP3,6B3W,6C23,6C24,6LO2,6SFB,6SFC,6U4Y,6V3X,6V3Y,6WKR,6YVI,6YVJ,7KSO,7KSR,7KTP,7KXT,7P3C,7P3G,7P3J,7QJG,7QJU,7QK4,7SI4,7SI5 Polycomb protein EED EED_HUMAN O75530 A8K7V5 O00149 Q6NTH2 Q7LDA5 Q7LDG8 Q86VV2 Q9UNY7 MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAVAAATASGGKSGGGSCGGGGSYSASSSSSAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTNIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSPNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVNEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPIAKPLATRNSESLHQENKPGSVKPTQTIAVKESLTTDLQTRKEKDTPNENRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESASPANEEITEEQNGTANGFSEINSKEKALETDSVSGVSKQSKKQKL 5HYN,5LS6,6C23,6C24,6WKR,7AT8,7KSO,7KSR,7KTP,7TD5 Polycomb protein SUZ12 SUZ12_HUMAN Q15022 Q96BD9 MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEEEEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEEDDEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSRMDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKRTLIRKVFNLYLSKQ 5WAI,5Y0U,6C23,6C24,6WKR,7KSO Zinc finger protein AEBP2 AEBP2_HUMAN Q6ZN18 Q59FS5 Q6ZN62 Q96BG3 MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS 2XU7,3GFC,4PBY,4PBZ,4PC0,4R7A,5FXY,5VTB,5WAI,5WAK,5XWR,5XXQ,5Y1U,6BW3,6BW4,6C23,6C24,6G16,6NQ3,6WKR,6ZRC,6ZRD,7AOA,7KSO,7KSR,7KTP,7M40,7N40,7R1D,7Y5K,7Y5L,7Y5O,7Y5U,7Y5V,8IQF,8IQG Histone-binding protein RBBP4 RBBP4_HUMAN Q09028 B2R6G9 B4DRH0 D3DPQ3 P31149 Q53H02 Q96BV9