BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 1322416 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)(F)F)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619410 US20230295130, Example T-34 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619410&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428875 485226716 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322420 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619411 US20230295130, Example T-35 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619411&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428876 485226717 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322424 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619412 US20230295130, Example T-36 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619412&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428877 485226718 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322428 COC(=O)Nc1ccc2c(c[nH]c2c1OC)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619413 US20230295130, Example T-37 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619413&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428878 485226719 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322436 CCOC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619418 US20230295130, Example T-42 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619418&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428883 485226724 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322440 CCOC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@@H]2CNCC(C)(C)C2)ncc1C(F)(F)F 619419 US20230295130, Example T-43 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619419&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428884 485226725 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322444 CC(C)OC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619420 US20230295130, Example T-44 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619420&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428885 485226726 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322451 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(O[C@H]2CCCN(C)C2)ncc1C(F)(F)F 619424 US20230295130, Example T-48 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619424&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428889 485226730 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322458 COC(=O)Nc1ccc2c(c[nH]c2c1C)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619428 US20230295130, Example T-52 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619428&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428891 485226732 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322469 COC(=O)Nc1ccc2c(c[nH]c2c1-c1ccccc1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619436 US20230295130, Example T-60 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619436&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428899 485226740 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322474 COCCOC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619438 US20230295130, Example T-62 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619438&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428901 485226742 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322478 COC(=O)Nc1ccc2c(c[nH]c2c1S(=O)(=O)C(C)C)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619439 US20230295130, Example T-63 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619439&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428902 485226743 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322482 COC(=O)Nc1ccc2c(c[nH]c2c1S(=O)(=O)C(C)C)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619440 US20230295130, Example T-64 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619440&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428903 485226744 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322486 COC(=O)Nc1ccc2c(c[nH]c2c1S(=O)C(C)C)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619441 US20230295130, Example T-65 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619441&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428904 485226745 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322490 COC(=O)Nc1ccc2c(c[nH]c2c1SC(C)C)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619442 US20230295130, Example T-66 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619442&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428905 485226746 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322494 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCC[C@@H]2N)ncc1C(F)(F)F 619443 US20230295130, Example T-67 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619443&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428906 485226747 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322498 COC(=O)Nc1ccc2c(c[nH]c2c1-c1cnn(C)c1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619444 US20230295130, Example T-68 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619444&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428907 485226748 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322502 COC(=O)Nc1ccc2c(c[nH]c2c1C(C)C)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619445 US20230295130, Example T-69 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619445&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428908 485226749 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322506 COC(=O)Nc1ccc2c(c[nH]c2c1C(C)=C)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619446 US20230295130, Example T-70 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619446&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428909 485226750 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322514 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1Br 619451 US20230295130, Example T-75 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619451&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428914 485226755 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322521 COC(=O)Nc1ccc2c(c[nH]c2c1Cl)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619455 US20230295130, Example T-79 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619455&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428918 485226759 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322525 COC(=O)Nc1ccc2c(c[nH]c2c1Cl)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619456 US20230295130, Example T-80 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619456&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428919 485226760 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322529 COC(=O)Nc1ccc2c(c[nH]c2c1Cl)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619457 US20230295130, Example T-81 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619457&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428920 485226761 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322533 CCOC(=O)Nc1ccc2c(c[nH]c2c1Cl)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619458 US20230295130, Example T-82 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619458&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428921 485226762 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322538 COC(=O)Nc1ccc2c(c[nH]c2c1C1COC1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619460 US20230295130, Example T-84 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619460&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428923 485226764 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322542 COC(=O)Nc1ccc2c(c[nH]c2c1OCC(F)(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1Cl 619461 US20230295130, Example T-85 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619461&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428924 485226765 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322546 COC(=O)Nc1ccc2c(c[nH]c2c1CC(F)(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1Cl 619462 US20230295130, Example T-86 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619462&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428925 485226766 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322551 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)(F)F)-c1nc(N[C@H]2CCCNC2)ncc1Cl 619464 US20230295130, Example T-88 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619464&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428927 485226768 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322562 COC(=O)Nc1ccc2c(c[nH]c2c1OC(F)(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1Cl 619472 US20230295130, Example T-96 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619472&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428935 485226776 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322568 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)(F)F)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619475 US20230295130, Example T-100 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619475&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058673 485226779 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322573 COC(=O)N(C)c1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619477 US20230295130, Example T-102 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619477&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058705 485226781 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322577 COC(=O)N(C)c1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619477 US20230295130, Example T-102 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619477&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058705 485226781 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322582 COC(=O)Nc1ccc2c(c[nH]c2c1C1CC1(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619479 US20230295130, Example T-105 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619479&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428939 485226783 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322586 COC(=O)Nc1ccc2c(c[nH]c2c1C1CC(F)(F)C1)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619480 US20230295130, Example T-106 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619480&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428940 485226784 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322590 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619481 US20230295130, Example T-107 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619481&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428941 485226785 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322594 COC(=O)Nc1ccc2c(c[nH]c2c1OC(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619482 US20230295130, Example T-108 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619482&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428942 485226786 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322598 COC(=O)Nc1ccc2c(c[nH]c2c1OC(F)(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619483 US20230295130, Example T-109 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619483&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428943 485226787 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322610 CCOC(=O)Nc1ccc2c(c[nH]c2c1C1CC1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619492 US20230295130, Example T-127 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619492&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428950 485226796 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322614 COC(=O)Nc1ccc2c(c[nH]c2c1C1CC1)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619493 US20230295130, Example T-128 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619493&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428951 485226797 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322618 COC(=O)Nc1ccc2c(c[nH]c2c1C1CC1)-c1nc(N[C@H]2CCC(C)NC2)ncc1C(F)(F)F 619494 US20230295130, Example T-129 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619494&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428952 485226798 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322622 COC(=O)Nc1ccc2c(c[nH]c2c1C1CC1)-c1nc(N[C@H]2CC[C@@H](C)NC2)ncc1C(F)(F)F 619495 US20230295130, Example T-130 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619495&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428953 485226799 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322626 COC(=O)Nc1ccc2c(c[nH]c2c1C1CC1)-c1nc(N[C@H]2CC[C@H](C)NC2)ncc1C(F)(F)F 619496 US20230295130, Example T-131 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619496&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428954 485226800 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322630 COC(=O)Nc1ccc2c(c[nH]c2c1OC)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619497 US20230295130, Example T-132 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619497&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428955 485226801 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322635 COC(=O)Nc1ccc2c(c[nH]c2c1C(C)=O)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619499 US20230295130, Example T-134 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619499&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058666 485226803 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322639 COC(=O)Nc1ccc2c(c[nH]c2c1C(C)=O)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619500 US20230295130, Example T-135 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619500&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058721 485226804 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322643 COC(=O)Nc1ccc2c(c[nH]c2c1C(C)(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619501 US20230295130, Example T-136 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619501&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058684 485226805 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322647 COC(=O)Nc1ccc2c(c[nH]c2c1C(C)(F)F)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619502 US20230295130, Example T-137 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619502&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058688 485226806 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322651 CCOc1c(NC(=O)OC)ccc2c(c[nH]c12)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619503 US20230295130, Example T-138 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619503&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428957 485226807 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322655 COC(=O)Nc1ccc2c(c[nH]c2c1OCC(F)(F)F)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619504 US20230295130, Example T-139 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619504&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428958 485226808 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322659 COC(=O)Nc1ccc2c(c[nH]c2c1OC)-c1nc(N[C@H]2CC[C@@H](C)NC2)ncc1C(F)(F)F 619505 US20230295130, Example T-140 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619505&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428959 485226809 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322664 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619507 US20230295130, Example T-142 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619507&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428961 485226811 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322668 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CC[C@@H](C)NC2)ncc1C(F)(F)F 619508 US20230295130, Example T-143 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619508&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428962 485226812 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322674 COC(=O)Nc1ccc2c(c[nH]c2c1Cl)-c1nc(N[C@H]2CC[C@@H](C)NC2)ncc1C(F)(F)F 619511 US20230295130, Example T-146 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619511&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058706 485226815 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322680 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)(F)F)-c1nc(N[C@H]2CC[C@@H](C)NC2)ncc1C(F)(F)F 619514 US20230295130, Example T-149 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619514&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058715 485226818 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322684 COC(=O)Nc1ccc2c(c[nH]c2c1OCC(F)(F)F)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619515 US20230295130, Example T-150 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619515&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428964 485226819 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322688 COC(=O)Nc1ccc2c(c[nH]c2c1OCC(F)(F)F)-c1nc(N[C@H]2CC[C@@H](C)NC2)ncc1C(F)(F)F 619516 US20230295130, Example T-151 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619516&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428965 485226820 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322693 CCOC(=O)Nc1ccc2c(c[nH]c2c1C(C)(F)F)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 619518 US20230295130, Example T-153 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619518&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058654 485226822 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322697 COC(=O)Nc1ccc2c(c[nH]c2c1OC(F)F)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619484 US20230295130, Example T-110::US20230295130, Example T-154 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619484&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058661 485226788 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322701 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)F)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619520 US20230295130, Example T-155 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619520&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058699 485226823 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322705 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)F)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 619521 US20230295130, Example T-156 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619521&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428967 485226824 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322711 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)F)-c1nc(N[C@H]2CCCN(C)C2)ncc1C(F)(F)F 619524 US20230295130, Example T-160::US20230295130, Example T-169 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619524&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058701 485226827 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322715 CCOc1c(NC(=O)OC)ccc2c(c[nH]c12)-c1nc(N[C@H]2CCCN(C)C2)ncc1C(F)(F)F 619525 US20230295130, Example T-161 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619525&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058713 485226828 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322719 COC(=O)N(C)c1ccc2c(c[nH]c2c1Cl)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619526 US20230295130, Example T-162 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619526&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058656 485226829 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322723 COC(=O)N(C)c1ccc2c(c[nH]c2c1C(F)F)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619527 US20230295130, Example T-163 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619527&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058651 485226830 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322727 COC(=O)N(C)c1ccc2c(c[nH]c2c1C(F)(F)F)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619528 US20230295130, Example T-164 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619528&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058696 485226831 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322731 COC(=O)N(C)c1ccc2c(c[nH]c2c1OC(F)F)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619529 US20230295130, Example T-165 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619529&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058694 485226832 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322737 COC(=O)Nc1ccc2c(c[nH]c2c1Cl)-c1nc(N[C@H]2CCCN(C)C2)ncc1C(F)(F)F 619532 US20230295130, Example T-168 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619532&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058657 485226835 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322741 COC(=O)Nc1ccc2c(c[nH]c2c1C(F)F)-c1nc(N[C@H]2CCCN(C)C2)ncc1C(F)(F)F 619524 US20230295130, Example T-160::US20230295130, Example T-169 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619524&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169058701 485226827 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322289 CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1 YISMQBFJYDFMAL-AESIHLKFSA-N 139540 US10189849, staurosporine::US10307427, Staurosporine::US10329300, Staurosporine::US11091485, Compound Staurosporine::US11542261, Compound staurosporine::US20230312583, Compound staurosporine::US8889696, Staurosporine::US9051313, Staurosporine::US9586965, Control Staurosporine Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139540&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 91669270 249871008 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322293 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619377 US20230295130, Example T-01 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619377&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 162641734 485226683 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322297 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(O[C@H]2CCCNC2)ncc1C(F)(F)F 619378 US20230295130, Example T-02 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619378&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428847 485226684 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322301 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(Br)c(ccc12)N1CCCCC1=O 619379 US20230295130, Example T-03 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619379&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428848 485226685 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322305 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(Br)c(ccc12)N1CCCC1=O 619380 US20230295130, Example T-04 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619380&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428849 485226686 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322309 CN1CCC[C@@H](C1)Nc1ncc(c(n1)-c1c[nH]c2cc(ccc12)N1CCCC1=O)C(F)(F)F 619381 US20230295130, Example T-05 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619381&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428850 485226687 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322313 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(Br)c(ccc12)N1CCCOC1=O 619382 US20230295130, Example T-06 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619382&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428851 485226688 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322317 CC1(C)COC(Nc2ccc3c(c[nH]c3c2Br)-c2nc(N[C@H]3CCCNC3)ncc2C(F)(F)F)=N1 619383 US20230295130, Example T-07 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619383&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428852 485226689 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322321 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(Br)c(NC(=O)C3CC3)ccc12 619384 US20230295130, Example T-08 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619384&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428853 485226690 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322325 CC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619385 US20230295130, Example T-09 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619385&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428854 485226691 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322329 CC(=O)Nc1ccc2c(c[nH]c2c1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619386 US20230295130, Example T-10 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619386&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428855 485226692 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322333 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(NC(=O)C3CC3)ccc12 619387 US20230295130, Example T-11 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619387&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428856 485226693 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322337 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(Br)c(ccc12)N1CCOC1=O 619388 US20230295130, Example T-12 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619388&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428857 485226694 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322341 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(ccc12)N1CCCC1=O 619389 US20230295130, Example T-13 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619389&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428858 485226695 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322345 COC(=O)Nc1ccc2c(c[nH]c2c1P(C)(C)=O)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619390 US20230295130, Example T-14 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619390&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 163907360 485226696 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322349 CC(=O)Nc1ccc2c(c[nH]c2c1P(C)(C)=O)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619391 US20230295130, Example T-15 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619391&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 163980609 485226697 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322353 COC(=O)Nc1ccc2c(c[nH]c2c1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619392 US20230295130, Example T-16 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619392&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428859 485226698 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322357 COC(=O)Nc1ccc2c(c[nH]c2c1C1CC1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619393 US20230295130, Example T-17 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619393&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428860 485226699 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322361 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(Br)c(ccc12)N1CCC1=O 619394 US20230295130, Example T-18 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619394&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428861 485226700 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322365 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(NC2CC3(CNC3)C2)ncc1C(F)(F)F InChI=1S/C21H20BrF3N6O2/c1-33-19(32)30-14-3-2-11-12(6-27-17(11)15(14)22)16-13(21(23,24)25)7-28-18(31-16)29-10-4-20(5-10)8-26-9-20/h2-3,6-7,10,26-27H,4-5,8-9H2,1H3,(H,30,32)(H,28,29,31) TVAJQMOTNSNWDG-UHFFFAOYSA-N 619395 US20230295130, Example T-19 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619395&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428862 485226701 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322369 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCC[C@H](N)C2)ncc1C(F)(F)F 619396 US20230295130, Example T-20 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619396&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428863 485226702 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322373 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCC[C@@H](N)C2)ncc1C(F)(F)F 619397 US20230295130, Example T-21 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619397&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428864 485226703 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322377 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@@H]2CCC[C@H](N)C2)ncc1C(F)(F)F 619398 US20230295130, Example T-22 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619398&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428865 485226704 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322381 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@@H]2CCC[C@@H](N)C2)ncc1C(F)(F)F 619399 US20230295130, Example T-23 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619399&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428866 485226705 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322385 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@@H]2[C@H]3CNC[C@@H]23)ncc1C(F)(F)F 619400 US20230295130, Example T-24 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619400&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428867 485226706 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322389 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2[C@H]3CNC[C@@H]23)ncc1C(F)(F)F 619401 US20230295130, Example T-25 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619401&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428867 485226707 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322393 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(NC2C3CCNC23)ncc1C(F)(F)F 619402 US20230295130, Example T-26 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619402&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428868 485226708 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322397 COC(=O)Nc1ccc2c(c[nH]c2c1C#N)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 619403 US20230295130, Example T-27 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619403&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428869 485226709 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322401 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(NC2CC3CNCC3C2)ncc1C(F)(F)F 619404 US20230295130, Example T-28 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619404&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428870 485226710 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322405 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(N[C@H]2CCC[C@@H](O)C2)ncc1C(F)(F)F 619405 US20230295130, Example T-29::US20230295130, Example T-51 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619405&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428871 485226711 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9 1322410 COC(=O)Nc1ccc2c(c[nH]c2c1Br)-c1nc(NC2CC3(CC(N)C3)C2)ncc1C(F)(F)F InChI=1S/C22H22BrF3N6O2/c1-34-20(33)31-15-3-2-12-13(8-28-18(12)16(15)23)17-14(22(24,25)26)9-29-19(32-17)30-11-6-21(7-11)4-10(27)5-21/h2-3,8-11,28H,4-7,27H2,1H3,(H,31,33)(H,29,30,32) JICAIOWSCOLKSA-UHFFFAOYSA-N 619407 US20230295130, Example T-31 Cyclin-K/Cyclin-dependent kinase 12 Homo sapiens >500 US Patent 10.7270/Q2TB1C2B US20230295130 LI, J; LIANG, A; WU, Y; DONG, S; LI, M; NIU, C TYK MEDICINES, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=619407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=366&target=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=619407&enzyme=Cyclin-K%2FCyclin-dependent+kinase+12&column=ki&startPg=0&Increment=50&submit=Search 169428873 485226713 2 PEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTSTEPVKNS Cyclin-dependent kinase 12 CDK12_HUMAN Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978 MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPPVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPPPGMPPVGGLGRAAWMR 2I53,4NST,5EFQ,6B3E,6CKX,6TD3,7NXJ,7NXK,8BU1,8BU2,8BU3,8BU4,8BU5,8BU6,8BU7,8BU9,8BUA,8BUB,8BUC,8BUD,8BUE,8BUF,8BUG,8BUH,8BUI,8BUJ,8BUK,8BUL,8BUM,8BUN,8BUO,8BUP,8BUQ,8BUR,8BUS,8BUT Cyclin-K CCNK_HUMAN O75909 Q59FT6 Q86U16 Q96B63 Q9NNY9