BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 51078307 CCOc1cc(ccc1OC(C)C)[C@@H](Nc1ccc2c(N)nccc2c1)C(=O)NS(=O)(=O)c1cccc(c1)S(N)(=O)=O InChI=1S/C28H31N5O7S2/c1-4-39-25-15-19(8-11-24(25)40-17(2)3)26(32-20-9-10-23-18(14-20)12-13-31-27(23)29)28(34)33-42(37,38)22-7-5-6-21(16-22)41(30,35)36/h5-17,26,32H,4H2,1-3H3,(H2,29,31)(H,33,34)(H2,30,35,36)/t26-/m1/s1 OJQSHFQBQLMRKM-AREMUKBSSA-N 50440822 CHEMBL2431602 Coagulation factor X Homo sapiens 5600 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440822&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72164699 175453139 CHEMBL2431602 ZINC96284558 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078308 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2c(N)nccc2c1)C(=O)NS(=O)(=O)c1cccc(O)c1 InChI=1S/C28H30N4O6S/c1-4-37-25-15-19(8-11-24(25)38-17(2)3)26(28(34)32-39(35,36)22-7-5-6-21(33)16-22)31-20-9-10-23-18(14-20)12-13-30-27(23)29/h5-17,26,31,33H,4H2,1-3H3,(H2,29,30)(H,32,34) NSKJHJNUMAJGCP-UHFFFAOYSA-N 50440823 CHEMBL2431597 Coagulation factor X Homo sapiens 5500 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440823&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10053298 175453140 CHEMBL2431597 ZINC43063146 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078309 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2cnccc2c1)C(=O)NS(=O)(=O)c1ccccc1 InChI=1S/C28H29N3O5S/c1-4-35-26-17-21(11-13-25(26)36-19(2)3)27(28(32)31-37(33,34)24-8-6-5-7-9-24)30-23-12-10-22-18-29-15-14-20(22)16-23/h5-19,27,30H,4H2,1-3H3,(H,31,32) SYQCWEBXGKFEOO-UHFFFAOYSA-N 50440824 CHEMBL2431590 Coagulation factor X Homo sapiens 5400 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440824&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10098156 175453141 CHEMBL2431590 ZINC96284560 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078310 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2c(N)nccc2c1)C(=O)NS(=O)(=O)c1ccccc1 InChI=1S/C28H30N4O5S/c1-4-36-25-17-20(10-13-24(25)37-18(2)3)26(28(33)32-38(34,35)22-8-6-5-7-9-22)31-21-11-12-23-19(16-21)14-15-30-27(23)29/h5-18,26,31H,4H2,1-3H3,(H2,29,30)(H,32,33) ICZUITMFGXCICW-UHFFFAOYSA-N 50440825 CHEMBL2431589 Coagulation factor X Homo sapiens 3500 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440825&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1OK 4JYU 10392348 175453142 CHEMBL2431589 ZINC96284562 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078311 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2c(N)nccc2c1)C(=O)NS(=O)(=O)c1ccc(C)cc1 InChI=1S/C29H32N4O5S/c1-5-37-26-17-21(8-13-25(26)38-18(2)3)27(29(34)33-39(35,36)23-10-6-19(4)7-11-23)32-22-9-12-24-20(16-22)14-15-31-28(24)30/h6-18,27,32H,5H2,1-4H3,(H2,30,31)(H,33,34) JMQSBZFTYXIKKK-UHFFFAOYSA-N 50440826 CHEMBL2431605 Coagulation factor X Homo sapiens 3050 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440826&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10415115 175453143 CHEMBL2431605 ZINC96284564 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078332 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2cnccc2c1)C(=O)NS(=O)(=O)c1ccccc1S(=O)(=O)CC InChI=1S/C30H33N3O7S2/c1-5-39-26-18-22(12-14-25(26)40-20(3)4)29(32-24-13-11-23-19-31-16-15-21(23)17-24)30(34)33-42(37,38)28-10-8-7-9-27(28)41(35,36)6-2/h7-20,29,32H,5-6H2,1-4H3,(H,33,34) YRIAAWIYWKODTC-UHFFFAOYSA-N 50440843 CHEMBL2431614 Coagulation factor X Homo sapiens >8000 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440843&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72164568 175453160 CHEMBL2431614 ZINC96284588 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078333 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2cnccc2c1)C(=O)NS(=O)(=O)c1ccc(cc1)S(C)(=O)=O InChI=1S/C29H31N3O7S2/c1-5-38-27-17-21(7-13-26(27)39-19(2)3)28(31-23-8-6-22-18-30-15-14-20(22)16-23)29(33)32-41(36,37)25-11-9-24(10-12-25)40(4,34)35/h6-19,28,31H,5H2,1-4H3,(H,32,33) QRBRQCGLKZWLJF-UHFFFAOYSA-N 50440844 CHEMBL2431613 Coagulation factor X Homo sapiens >8000 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440844&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72164567 175453161 CHEMBL2431613 ZINC96284590 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078334 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2cnccc2c1)C(=O)NS(=O)(=O)c1cccc(c1)S(C)(=O)=O InChI=1S/C29H31N3O7S2/c1-5-38-27-16-21(10-12-26(27)39-19(2)3)28(31-23-11-9-22-18-30-14-13-20(22)15-23)29(33)32-41(36,37)25-8-6-7-24(17-25)40(4,34)35/h6-19,28,31H,5H2,1-4H3,(H,32,33) OZCRTXUHVCJERL-UHFFFAOYSA-N 50440835 CHEMBL2431612 Coagulation factor X Homo sapiens >8000 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440835&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72164564 175453152 CHEMBL2431612 ZINC96284576 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078335 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2cnccc2c1)C(=O)NS(=O)(=O)c1ccccc1S(C)(=O)=O InChI=1S/C29H31N3O7S2/c1-5-38-25-17-21(11-13-24(25)39-19(2)3)28(31-23-12-10-22-18-30-15-14-20(22)16-23)29(33)32-41(36,37)27-9-7-6-8-26(27)40(4,34)35/h6-19,28,31H,5H2,1-4H3,(H,32,33) ZDPIURLELGMDQA-UHFFFAOYSA-N 50440845 CHEMBL2431611 Coagulation factor X Homo sapiens >8000 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440845&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72164445 175453162 CHEMBL2431611 ZINC96284592 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078336 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2cnccc2c1)C(=O)NS(=O)(=O)c1ccc(cc1)S(N)(=O)=O InChI=1S/C28H30N4O7S2/c1-4-38-26-16-20(6-12-25(26)39-18(2)3)27(31-22-7-5-21-17-30-14-13-19(21)15-22)28(33)32-41(36,37)24-10-8-23(9-11-24)40(29,34)35/h5-18,27,31H,4H2,1-3H3,(H,32,33)(H2,29,34,35) PYDCKOIQIUSOKE-UHFFFAOYSA-N 50440832 CHEMBL2431610 Coagulation factor X Homo sapiens >8000 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440832&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72164444 175453149 CHEMBL2431610 ZINC96284572 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078337 CCOc1cc(ccc1OC(C)C)[C@@H](Nc1ccc2cnccc2c1)C(=O)NS(=O)(=O)c1cccc(c1)S(N)(=O)=O InChI=1S/C28H30N4O7S2/c1-4-38-26-15-20(9-11-25(26)39-18(2)3)27(31-22-10-8-21-17-30-13-12-19(21)14-22)28(33)32-41(36,37)24-7-5-6-23(16-24)40(29,34)35/h5-18,27,31H,4H2,1-3H3,(H,32,33)(H2,29,34,35)/t27-/m1/s1 QHVDUHFNSHQJRC-HHHXNRCGSA-N 50440842 CHEMBL2431609 Coagulation factor X Homo sapiens >8000 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440842&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1OJ 4JYV 71627416 175453159 CHEMBL2431609 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078338 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2cnccc2c1)C(=O)NS(=O)(=O)c1cccc(c1)S(N)(=O)=O InChI=1S/C28H30N4O7S2/c1-4-38-26-15-20(9-11-25(26)39-18(2)3)27(31-22-10-8-21-17-30-13-12-19(21)14-22)28(33)32-41(36,37)24-7-5-6-23(16-24)40(29,34)35/h5-18,27,31H,4H2,1-3H3,(H,32,33)(H2,29,34,35) QHVDUHFNSHQJRC-UHFFFAOYSA-N 50440839 CHEMBL2431608 Coagulation factor X Homo sapiens >8000 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440839&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1OJ 4JYV 11758260 175453156 CHEMBL2431608 ZINC96284582 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078339 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2cnccc2c1)C(=O)NS(=O)(=O)c1ccccc1S(N)(=O)=O InChI=1S/C28H30N4O7S2/c1-4-38-24-16-20(10-12-23(24)39-18(2)3)27(31-22-11-9-21-17-30-14-13-19(21)15-22)28(33)32-41(36,37)26-8-6-5-7-25(26)40(29,34)35/h5-18,27,31H,4H2,1-3H3,(H,32,33)(H2,29,34,35) CELJOOCMAQSNFW-UHFFFAOYSA-N 50440836 CHEMBL2431607 Coagulation factor X Homo sapiens >8000 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440836&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72164443 175453153 CHEMBL2431607 ZINC96284578 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078340 CCOc1cc(ccc1OC(C)C)[C@@H](Nc1ccc2cnccc2c1)C(=O)NS(=O)(=O)c1ccccc1 InChI=1S/C28H29N3O5S/c1-4-35-26-17-21(11-13-25(26)36-19(2)3)27(28(32)31-37(33,34)24-8-6-5-7-9-24)30-23-12-10-22-18-29-15-14-20(22)16-23/h5-19,27,30H,4H2,1-3H3,(H,31,32)/t27-/m1/s1 SYQCWEBXGKFEOO-HHHXNRCGSA-N 50440838 CHEMBL2431606 Coagulation factor X Homo sapiens >8000 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440838&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72164566 175453155 CHEMBL2431606 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078341 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2c(N)nccc2c1)C(=O)NS(=O)(=O)c1ccc(O)cc1 InChI=1S/C28H30N4O6S/c1-4-37-25-16-19(5-12-24(25)38-17(2)3)26(28(34)32-39(35,36)22-9-7-21(33)8-10-22)31-20-6-11-23-18(15-20)13-14-30-27(23)29/h5-17,26,31,33H,4H2,1-3H3,(H2,29,30)(H,32,34) YAUIYXQWYKBVHU-UHFFFAOYSA-N 50440846 CHEMBL2431603 Coagulation factor X Homo sapiens >8000 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440846&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10325259 175453163 CHEMBL2431603 ZINC43063120 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078342 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2c(N)nccc2c1)C(=O)NS(=O)(=O)c1cccc(N)c1 InChI=1S/C28H31N5O5S/c1-4-37-25-15-19(8-11-24(25)38-17(2)3)26(28(34)33-39(35,36)22-7-5-6-20(29)16-22)32-21-9-10-23-18(14-21)12-13-31-27(23)30/h5-17,26,32H,4,29H2,1-3H3,(H2,30,31)(H,33,34) XGRVTTDWPRPYFC-UHFFFAOYSA-N 50440837 CHEMBL2431600 Coagulation factor X Homo sapiens >8000 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440837&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10099038 175453154 CHEMBL2431600 ZINC96284580 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078343 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2c(N)nccc2c1)C(=O)NS(=O)(=O)c1cccc(CO)c1 InChI=1S/C29H32N4O6S/c1-4-38-26-16-21(8-11-25(26)39-18(2)3)27(32-22-9-10-24-20(15-22)12-13-31-28(24)30)29(35)33-40(36,37)23-7-5-6-19(14-23)17-34/h5-16,18,27,32,34H,4,17H2,1-3H3,(H2,30,31)(H,33,35) HYICEUCVGOEDNX-UHFFFAOYSA-N 50440840 CHEMBL2431599 Coagulation factor X Homo sapiens >8000 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440840&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69641445 175453157 CHEMBL2431599 ZINC96284584 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078344 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2c(N)nccc2c1)C(=O)NS(=O)(=O)c1cccc(c1)C(N)=O InChI=1S/C29H31N5O6S/c1-4-39-25-16-19(8-11-24(25)40-17(2)3)26(33-21-9-10-23-18(14-21)12-13-32-27(23)30)29(36)34-41(37,38)22-7-5-6-20(15-22)28(31)35/h5-17,26,33H,4H2,1-3H3,(H2,30,32)(H2,31,35)(H,34,36) XMYBUOHBAIWKLS-UHFFFAOYSA-N 50440841 CHEMBL2431598 Coagulation factor X Homo sapiens >8000 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440841&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10099674 175453158 CHEMBL2431598 ZINC96284586 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078345 CCOc1cc(ccc1OC(C)C)[C@H](Nc1ccc2c(N)nccc2c1)C(=O)NS(=O)(=O)c1ccccc1 InChI=1S/C28H30N4O5S/c1-4-36-25-17-20(10-13-24(25)37-18(2)3)26(28(33)32-38(34,35)22-8-6-5-7-9-22)31-21-11-12-23-19(16-21)14-15-30-27(23)29/h5-18,26,31H,4H2,1-3H3,(H2,29,30)(H,32,33)/t26-/m0/s1 ICZUITMFGXCICW-SANMLTNESA-N 50440833 CHEMBL2431596 Coagulation factor X Homo sapiens 8200 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440833&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72164565 175453150 CHEMBL2431596 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078347 CCOc1cc(ccc1OC(C)C)[C@@H](Nc1ccc2c(N)nccc2c1)C(=O)NS(=O)(=O)c1ccccc1 InChI=1S/C28H30N4O5S/c1-4-36-25-17-20(10-13-24(25)37-18(2)3)26(28(33)32-38(34,35)22-8-6-5-7-9-22)31-21-11-12-23-19(16-21)14-15-30-27(23)29/h5-18,26,31H,4H2,1-3H3,(H2,29,30)(H,32,33)/t26-/m1/s1 ICZUITMFGXCICW-AREMUKBSSA-N 50440847 CHEMBL2431595 Coagulation factor X Homo sapiens 7300 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440847&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1OK 4JYU 69295008 175453164 CHEMBL2431595 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078356 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2cnccc2c1)C(=O)NS(=O)(=O)c1cccc(c1)S(=O)(=O)N(C)C InChI=1S/C30H34N4O7S2/c1-6-40-28-17-22(11-13-27(28)41-20(2)3)29(32-24-12-10-23-19-31-15-14-21(23)16-24)30(35)33-42(36,37)25-8-7-9-26(18-25)43(38,39)34(4)5/h7-20,29,32H,6H2,1-5H3,(H,33,35) XUQKAUFTHKINJE-UHFFFAOYSA-N 50440829 CHEMBL2431616 Coagulation factor X Homo sapiens 7200 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440829&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72164698 175453146 CHEMBL2431616 ZINC96284568 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078357 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2cnccc2c1)C(=O)NS(=O)(=O)c1cccc(c1)S(=O)(=O)NC InChI=1S/C29H32N4O7S2/c1-5-39-27-16-21(10-12-26(27)40-19(2)3)28(32-23-11-9-22-18-31-14-13-20(22)15-23)29(34)33-42(37,38)25-8-6-7-24(17-25)41(35,36)30-4/h6-19,28,30,32H,5H2,1-4H3,(H,33,34) COTKEKIZTQTBEH-UHFFFAOYSA-N 50440834 CHEMBL2431615 Coagulation factor X Homo sapiens 7000 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440834&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72164697 175453151 CHEMBL2431615 ZINC96284574 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078358 CCOc1cc(ccc1OC(C)C)[C@@H](Nc1ccc2c(N)nccc2c1)C(=O)NS(=O)(=O)c1cccc(c1)S(N)(=O)=O InChI=1S/C28H31N5O7S2/c1-4-39-25-15-19(8-11-24(25)40-17(2)3)26(32-20-9-10-23-18(14-20)12-13-31-27(23)29)28(34)33-42(37,38)22-7-5-6-21(16-22)41(30,35)36/h5-17,26,32H,4H2,1-3H3,(H2,29,31)(H,33,34)(H2,30,35,36)/t26-/m1/s1 OJQSHFQBQLMRKM-AREMUKBSSA-N 50440822 CHEMBL2431602 Coagulation factor X Homo sapiens 5900 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440822&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72164699 175453139 CHEMBL2431602 ZINC96284558 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51078359 CCOc1cc(ccc1OC(C)C)C(Nc1ccc2c(N)nccc2c1)C(=O)NS(=O)(=O)c1ccc(N)cc1 InChI=1S/C28H31N5O5S/c1-4-37-25-16-19(5-12-24(25)38-17(2)3)26(28(34)33-39(35,36)22-9-6-20(29)7-10-22)32-21-8-11-23-18(15-21)13-14-31-27(23)30/h5-17,26,32H,4,29H2,1-3H3,(H2,30,31)(H,33,34) SHLMUWKQBCZQDG-UHFFFAOYSA-N 50440848 CHEMBL2431604 Coagulation factor X Homo sapiens 5800 ChEMBL 10.1016/j.bmcl.2013.06.027 10.7270/Q2S46TDQ 23845220 Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Bristol-Myers Squibb R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440848&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10460210 175453165 CHEMBL2431604 ZINC96284594 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 51036262 NC(=N)c1ccc(CNC(=O)CN2c3ccccc3SC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)cc1 InChI=1S/C26H27N5O4S2/c27-25(28)20-12-10-18(11-13-20)14-29-24(32)15-31-22-8-4-5-9-23(22)36-16-21(26(31)33)30-37(34,35)17-19-6-2-1-3-7-19/h1-13,21,30H,14-17H2,(H3,27,28)(H,29,32)/t21-/m0/s1 LSLVCIWDJBWFRJ-NRFANRHFSA-N 50293379 (R)-N-(4-carbamimidoylbenzyl)-2-(4-oxo-3-(phenylmethylsulfonamido)-3,4-dihydrobenzo[b][1,4]thiazepin-5(2H)-yl)acetamide, trifluoroacetate::CHEMBL452174 Coagulation factor X Homo sapiens 3280 ChEMBL 10.1016/j.bmcl.2009.01.039 10.7270/Q2G73DRB 19181521 Ayral, E; Gloanec, P; Berge, G; de Nanteuil, G; Mennecier, P; Rupin, A; Verbeuren, TJ; Fulcrand, P; Martinez, J; Hernandez, JF University of Montpellier http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50293379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50293379&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44156919 104134930 CHEMBL452174 ZINC43021935 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 15660 Clc1ccc(s1)C(=O)NCC1CN(C(=O)O1)c1ccc(NC(=O)c2cccs2)cc1 InChI=1S/C20H16ClN3O4S2/c21-17-8-7-16(30-17)18(25)22-10-14-11-24(20(27)28-14)13-5-3-12(4-6-13)23-19(26)15-2-1-9-29-15/h1-9,14H,10-11H2,(H,22,25)(H,23,26) HUZANKQWACRXDD-UHFFFAOYSA-N 7997 US8822458, 156 Coagulation factor X Homo sapiens 1300 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7997&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21070682 242052800 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 15668 COCC(=O)Nc1ccc(cc1)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C18H18ClN3O5S/c1-26-10-16(23)21-11-2-4-12(5-3-11)22-9-13(27-18(22)25)8-20-17(24)14-6-7-15(19)28-14/h2-7,13H,8-10H2,1H3,(H,20,24)(H,21,23) BKDSZEWNGUNWLC-UHFFFAOYSA-N 8000 US8822458, 157 Coagulation factor X Homo sapiens 730 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8000&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21070732 242052801 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 15675 Cc1noc(C)c1C(=O)NCC1CN(C(=O)O1)c1ccc(CNC(=O)c2ccc(Cl)s2)cc1 InChI=1S/C22H21ClN4O5S/c1-12-19(13(2)32-26-12)21(29)25-10-16-11-27(22(30)31-16)15-5-3-14(4-6-15)9-24-20(28)17-7-8-18(23)33-17/h3-8,16H,9-11H2,1-2H3,(H,24,28)(H,25,29) XXLCRPICIKPFCY-UHFFFAOYSA-N 8017 US8822458, 158 Coagulation factor X Homo sapiens 460 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8017&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 90654079 242052802 ZINC04397455 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 15683 ClCCCS(=O)(=O)Nc1ccc(cc1)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C18H19Cl2N3O5S2/c19-8-1-9-30(26,27)22-12-2-4-13(5-3-12)23-11-14(28-18(23)25)10-21-17(24)15-6-7-16(20)29-15/h2-7,14,22H,1,8-11H2,(H,21,24) KGQZMGDQAHIPQC-UHFFFAOYSA-N 8245 US8822458, 159 Coagulation factor X Homo sapiens 1700 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8245&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21070723 242052803 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14567 Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1 InChI=1S/C19H20ClN3O4S/c20-17-6-5-16(28-17)18(24)21-11-15-12-23(19(25)27-15)14-3-1-13(2-4-14)22-7-9-26-10-8-22/h1-6,15H,7-12H2,(H,21,24)/t15-/m0/s1 KLGDIFUIQLJAAR-HNNXBMFYSA-N 7495 BAY 59-7939 Analog 7::US8822458, 2 Coagulation factor X Homo sapiens 43 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7495&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10273747 242052774 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14568 Fc1cc(ccc1N1CCNCC1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C19H20ClFN4O3S/c20-17-4-3-16(29-17)18(26)23-10-13-11-25(19(27)28-13)12-1-2-15(14(21)9-12)24-7-5-22-6-8-24/h1-4,9,13,22H,5-8,10-11H2,(H,23,26)/t13-/m0/s1 RCVMZVZBCGIKNQ-ZDUSSCGKSA-N 7532 BAY 59-7939 Analog 10::US8822458, 11 Coagulation factor X Homo sapiens 140 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7532&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10274887 242052775 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14569 Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCCC1=O InChI=1S/C19H18ClN3O4S/c20-16-8-7-15(28-16)18(25)21-10-14-11-23(19(26)27-14)13-5-3-12(4-6-13)22-9-1-2-17(22)24/h3-8,14H,1-2,9-11H2,(H,21,25)/t14-/m0/s1 CWYUNIAGLBIPIP-AWEZNQCLSA-N 7552 BAY 59-7939 Analog 11::US8822458, 17 Coagulation factor X Homo sapiens 4 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7552&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10202260 242052776 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14570 Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCCC1 InChI=1S/C19H20ClN3O3S/c20-17-8-7-16(27-17)18(24)21-11-15-12-23(19(25)26-15)14-5-3-13(4-6-14)22-9-1-2-10-22/h3-8,15H,1-2,9-12H2,(H,21,24)/t15-/m0/s1 IQOWGQZZKKHHOD-HNNXBMFYSA-N 7629 US8822458, 18 Coagulation factor X Homo sapiens 40 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7629&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10158209 242052777 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14571 CCN(CC)c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C19H22ClN3O3S/c1-3-22(4-2)13-5-7-14(8-6-13)23-12-15(26-19(23)25)11-21-18(24)16-9-10-17(20)27-16/h5-10,15H,3-4,11-12H2,1-2H3,(H,21,24)/t15-/m0/s1 UTGGEGWCQFMLAP-HNNXBMFYSA-N 7631 US8822458, 19 Coagulation factor X Homo sapiens 270 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7631&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10158337 242052778 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14572 Cc1cc(ccc1N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O)N1CCOCC1 InChI=1S/C20H22ClN3O4S/c1-13-10-14(23-6-8-27-9-7-23)2-3-16(13)24-12-15(28-20(24)26)11-22-19(25)17-4-5-18(21)29-17/h2-5,10,15H,6-9,11-12H2,1H3,(H,22,25)/t15-/m0/s1 OYFFEZUIIXCYJD-HNNXBMFYSA-N 7632 BAY 59-7939 Analog 15::US8822458, 36 Coagulation factor X Homo sapiens 1260 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7632&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11575714 242052779 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14573 Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(N2CCOCC2)c(Cl)c1 InChI=1S/C19H19Cl2N3O4S/c20-14-9-12(1-2-15(14)23-5-7-27-8-6-23)24-11-13(28-19(24)26)10-22-18(25)16-3-4-17(21)29-16/h1-4,9,13H,5-8,10-11H2,(H,22,25)/t13-/m0/s1 VRACWCMNTPKTQF-ZDUSSCGKSA-N 7633 US8822458, 37 Coagulation factor X Homo sapiens 33 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7633&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 57496710 242052780 ZINC00072455 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14587 Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(c(Cl)c1)S(=O)(=O)N1CCOCC1 InChI=1S/C19H19Cl2N3O6S2/c20-14-9-12(1-3-16(14)32(27,28)23-5-7-29-8-6-23)24-11-13(30-19(24)26)10-22-18(25)15-2-4-17(21)31-15/h1-4,9,13H,5-8,10-11H2,(H,22,25)/t13-/m0/s1 YIOYBSKHJXPYAY-ZDUSSCGKSA-N 7634 US8822458, 38 Coagulation factor X Homo sapiens 2000 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7634&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 90654074 242052781 ZINC00072455 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14588 Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(c(Cl)c1)S(=O)(=O)N1CCC1 InChI=1S/C18H17Cl2N3O5S2/c19-13-8-11(2-4-15(13)30(26,27)22-6-1-7-22)23-10-12(28-18(23)25)9-21-17(24)14-3-5-16(20)29-14/h2-5,8,12H,1,6-7,9-10H2,(H,21,24)/t12-/m0/s1 WFFCLUIVKGMBMX-LBPRGKRZSA-N 7638 US8822458, 39 Coagulation factor X Homo sapiens 840 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7638&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 90654075 242052782 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14590 CN(C)S(=O)(=O)c1ccc(cc1Cl)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C17H17Cl2N3O5S2/c1-21(2)29(25,26)14-5-3-10(7-12(14)18)22-9-11(27-17(22)24)8-20-16(23)13-4-6-15(19)28-13/h3-7,11H,8-9H2,1-2H3,(H,20,23)/t11-/m0/s1 WWDPDTBPVOZOHF-NSHDSACASA-N 7648 US8822458, 40 Coagulation factor X Homo sapiens 90 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7648&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 90654076 11108421 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14591 O=C(NCC1CN(C(=O)O1)c1ccc(cc1)N1CCCC1=O)c1cccs1 InChI=1S/C19H19N3O4S/c23-17-4-1-9-21(17)13-5-7-14(8-6-13)22-12-15(26-19(22)25)11-20-18(24)16-3-2-10-27-16/h2-3,5-8,10,15H,1,4,9,11-12H2,(H,20,24) XVEMBZCTWXFDEQ-UHFFFAOYSA-N 7650 US8822458, 41 Coagulation factor X Homo sapiens 1300 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7650&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23105360 242052783 ZINC03430638 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14592 Cc1ccc(s1)C(=O)NCC1CN(C(=O)O1)c1ccc(cc1)N1CCCC1=O InChI=1S/C20H21N3O4S/c1-13-4-9-17(28-13)19(25)21-11-16-12-23(20(26)27-16)15-7-5-14(6-8-15)22-10-2-3-18(22)24/h4-9,16H,2-3,10-12H2,1H3,(H,21,25) JDZMFDDYWDYSSV-UHFFFAOYSA-N 7654 US8822458, 42 Coagulation factor X Homo sapiens 160 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7654&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21070756 242052784 ZINC03430638 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14593 Brc1ccc(s1)C(=O)NCC1CN(C(=O)O1)c1ccc(cc1)N1CCCC1=O InChI=1S/C19H18BrN3O4S/c20-16-8-7-15(28-16)18(25)21-10-14-11-23(19(26)27-14)13-5-3-12(4-6-13)22-9-1-2-17(22)24/h3-8,14H,1-2,9-11H2,(H,21,25) ODBNMTFTNNWNCT-UHFFFAOYSA-N 7839 US8822458, 43 Coagulation factor X Homo sapiens 14 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7839&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21070661 242052785 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14595 Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1 KGFYHTZWPPHNLQ-AWEZNQCLSA-N 7840 RIVAROXABAN::US8822458, 44::US8822458, 97 Coagulation factor X Homo sapiens 700 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7840&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search RIV 5VOF,2W26 9875401 242052786 DB08477 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14596 Cc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C20H21N3O5S/c1-13-2-7-17(29-13)19(25)21-10-16-11-23(20(26)28-16)15-5-3-14(4-6-15)22-8-9-27-12-18(22)24/h2-7,16H,8-12H2,1H3,(H,21,25)/t16-/m0/s1 YWRVKEHHSZEJNV-INIZCTEOSA-N 7841 BAY 59-7939 Analog 18::US8822458, 45::US9359341, Rivaroxaban Coagulation factor X Homo sapiens 4.2 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7841&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11711363 242052787 ZINC95393419 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14597 Brc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C19H18BrN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1 RPXYGWOWNPRMRE-AWEZNQCLSA-N 7842 BAY 59-7939 Analog 17::US8822458, 46 Coagulation factor X Homo sapiens 300 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7842&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11569203 242052788 ZINC95393419 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14598 Clc1ccc(s1)C(=O)NCC1CN(C(=O)O1)c1ccccc1 InChI=1S/C15H13ClN2O3S/c16-13-7-6-12(22-13)14(19)17-8-11-9-18(15(20)21-11)10-4-2-1-3-5-10/h1-7,11H,8-9H2,(H,17,19) DEMJYVDXDRTKPZ-UHFFFAOYSA-N 7843 US8822458, 96 Coagulation factor X Homo sapiens 2000 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7843&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21070687 242052789 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14599 Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1 KGFYHTZWPPHNLQ-AWEZNQCLSA-N 7840 RIVAROXABAN::US8822458, 44::US8822458, 97 Coagulation factor X Homo sapiens 1.4 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7840&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search RIV 5VOF,2W26 9875401 242052786 DB08477 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14614 CC(=O)N(C1CC1)c1ccc(cc1)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C20H20ClN3O4S/c1-12(25)24(15-6-7-15)14-4-2-13(3-5-14)23-11-16(28-20(23)27)10-22-19(26)17-8-9-18(21)29-17/h2-5,8-9,15-16H,6-7,10-11H2,1H3,(H,22,26) XCYOXLDFXWCASJ-UHFFFAOYSA-N 7845 US8822458, 98 Coagulation factor X Homo sapiens 50 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7845&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21070781 242052790 ZINC00098977 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14615 Fc1cc(ccc1N1CCS(=O)CC1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C19H19ClFN3O4S2/c20-17-4-3-16(29-17)18(25)22-10-13-11-24(19(26)28-13)12-1-2-15(14(21)9-12)23-5-7-30(27)8-6-23/h1-4,9,13H,5-8,10-11H2,(H,22,25)/t13-/m0/s1 IWVHBEIQZWIBRE-ZDUSSCGKSA-N 7846 US8822458, 14 Coagulation factor X Homo sapiens 1100 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7846&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10183784 242052791 ZINC00098977 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14616 Fc1cc(ccc1N1CCS(=O)(=O)CC1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C19H19ClFN3O5S2/c20-17-4-3-16(30-17)18(25)22-10-13-11-24(19(26)29-13)12-1-2-15(14(21)9-12)23-5-7-31(27,28)8-6-23/h1-4,9,13H,5-8,10-11H2,(H,22,25)/t13-/m0/s1 AHQZLOQYCWPLBA-ZDUSSCGKSA-N 7847 US8822458, 15 Coagulation factor X Homo sapiens 210 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7847&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10228089 242052792 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14617 CNc1ccc(cc1F)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C16H15ClFN3O3S/c1-19-12-3-2-9(6-11(12)18)21-8-10(24-16(21)23)7-20-15(22)13-4-5-14(17)25-13/h2-6,10,19H,7-8H2,1H3,(H,20,22) YLNAICYSCWYRTL-UHFFFAOYSA-N 7849 US8822458, 148 Coagulation factor X Homo sapiens 2200 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7849&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 90654077 242052793 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14618 Nc1ccc(cc1F)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C15H13ClFN3O3S/c16-13-4-3-12(24-13)14(21)19-6-9-7-20(15(22)23-9)8-1-2-11(18)10(17)5-8/h1-5,9H,6-7,18H2,(H,19,21) IUNKWRMKIQXHKM-UHFFFAOYSA-N 7850 US8822458, 149 Coagulation factor X Homo sapiens 2000 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7850&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 90654078 242052794 ZINC20026981 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14619 NCC(=O)Nc1ccc(cc1)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C17H17ClN4O4S/c18-14-6-5-13(27-14)16(24)20-8-12-9-22(17(25)26-12)11-3-1-10(2-4-11)21-15(23)7-19/h1-6,12H,7-9,19H2,(H,20,24)(H,21,23) SQPPEVRCRPVSFD-UHFFFAOYSA-N 7940 US8822458, 150 Coagulation factor X Homo sapiens 2000 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7940&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21070731 242052795 ZINC20026981 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14620 NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C14H17N3O4/c15-7-12-8-17(14(19)21-12)11-3-1-10(2-4-11)16-5-6-20-9-13(16)18/h1-4,12H,5-9,15H2/t12-/m0/s1 DEXXSYVEWAYIGZ-LBPRGKRZSA-N 7941 US8822458, 151 Coagulation factor X Homo sapiens 2000 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7941&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11346837 242052796 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 15756 Clc1ccc(s1)C(=O)NCC1CN(C(=O)O1)c1ccc(cc1)N1CCCS1(=O)=O InChI=1S/C18H18ClN3O5S2/c19-16-7-6-15(28-16)17(23)20-10-14-11-21(18(24)27-14)12-2-4-13(5-3-12)22-8-1-9-29(22,25)26/h2-7,14H,1,8-11H2,(H,20,23) QFFAOYFYUAVBEM-UHFFFAOYSA-N 8298 US8822458, 160 Coagulation factor X Homo sapiens 140 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8298&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 57804329 242052804 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 14642 CC(=O)NCc1ccc(cc1)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C18H18ClN3O4S/c1-11(23)20-8-12-2-4-13(5-3-12)22-10-14(26-18(22)25)9-21-17(24)15-6-7-16(19)27-15/h2-7,14H,8-10H2,1H3,(H,20,23)(H,21,24) OSQBVNRIDCZDCS-UHFFFAOYSA-N 7943 US8822458, 153 Coagulation factor X Homo sapiens 600 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7943&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21070779 242052797 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 15808 Fc1cc(ccc1N1CCCCC1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C20H19ClFN3O4S/c21-17-7-6-16(30-17)19(27)23-10-13-11-25(20(28)29-13)12-4-5-15(14(22)9-12)24-8-2-1-3-18(24)26/h4-7,9,13H,1-3,8,10-11H2,(H,23,27)/t13-/m0/s1 JYJRNYBWKWCQRQ-ZDUSSCGKSA-N 8299 US8822458, 162 Coagulation factor X Homo sapiens 2.8 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8299&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 90654080 242052805 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 15809 Fc1cc(ccc1N1CCC1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C18H15ClFN3O4S/c19-15-4-3-14(28-15)17(25)21-8-11-9-23(18(26)27-11)10-1-2-13(12(20)7-10)22-6-5-16(22)24/h1-4,7,11H,5-6,8-9H2,(H,21,25)/t11-/m0/s1 NSOLQXURNXELQF-NSHDSACASA-N 8361 US8822458, 164 Coagulation factor X Homo sapiens 380 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8361&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 90654081 242052806 ZINC00189898 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 15810 CC(C)(C)OC(=O)N1CC(=O)N(C(=O)C1)c1ccc(cc1)N1CC(COC(=O)[N]2=CC=C(Cl)S2)OC1=O InChI=1S/C23H24ClN4O8S/c1-23(2,3)36-20(31)25-11-18(29)28(19(30)12-25)15-6-4-14(5-7-15)26-10-16(35-21(26)32)13-34-22(33)27-9-8-17(24)37-27/h4-9,16H,10-13H2,1-3H3 WLDUQXQRYVHOFW-UHFFFAOYSA-N 8362 US8822458, 165 Coagulation factor X Homo sapiens 2000 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8362&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 90654082 242052807 ZINC00189898 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 15011 NC(=O)NCc1ccc(cc1)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C17H17ClN4O4S/c18-14-6-5-13(27-14)15(23)20-8-12-9-22(17(25)26-12)11-3-1-10(2-4-11)7-21-16(19)24/h1-6,12H,7-9H2,(H,20,23)(H3,19,21,24) VEDPEZVHGAYYBV-UHFFFAOYSA-N 7958 US8822458, 154 Coagulation factor X Homo sapiens 1300 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7958&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21070785 242052798 ZINC00489632 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 15012 CC(=O)Nc1ccc(cc1)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C17H16ClN3O4S/c1-10(22)20-11-2-4-12(5-3-11)21-9-13(25-17(21)24)8-19-16(23)14-6-7-15(18)26-14/h2-7,13H,8-9H2,1H3,(H,19,23)(H,20,22) BXMKQFJSSNEYSN-UHFFFAOYSA-N 7964 US8822458, 155 Coagulation factor X Homo sapiens 1200 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7964&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21070780 242052799 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 16465 Clc1ccc(s1)C(=O)NCC1CN(C(=O)O1)c1ccc(cc1)S(=O)(=O)N1CCCC1 InChI=1S/C19H20ClN3O5S2/c20-17-8-7-16(29-17)18(24)21-11-14-12-23(19(25)28-14)13-3-5-15(6-4-13)30(26,27)22-9-1-2-10-22/h3-8,14H,1-2,9-12H2,(H,21,24) OAJGJVSOQZSABH-UHFFFAOYSA-N 8363 US8822458, 167 Coagulation factor X Homo sapiens 500 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8363&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21070680 242052808 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26091 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1ccccc1O InChI=1S/C14H12N4O/c15-13(16)8-5-6-10-11(7-8)18-14(17-10)9-3-1-2-4-12(9)19/h1-7,19H,(H3,15,16)(H,17,18)/p+1 URJKRCBBKTXOHS-UHFFFAOYSA-O 13937 2-(2-HYDROXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE::APC-1144::{amino[2-(2-hydroxyphenyl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 11000 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13937&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 122 1GI2,1GI4 5353306 46514312 DB02287 ZINC31976714 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26092 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1ncccc1O InChI=1S/C13H11N5O/c14-12(15)7-3-4-8-9(6-7)18-13(17-8)11-10(19)2-1-5-16-11/h1-6,19H,(H3,14,15)(H,17,18)/p+1 FQCDQFDJHSXQKY-UHFFFAOYSA-O 13940 2-(3-HYDROXY-PYRIDIN-2-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE::APC-1801::{amino[2-(3-hydroxypyridin-2-yl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 6900 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13940&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1GHY,1O31,1O32,1O33,1O34 5326681 46514314 ZINC18163907 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22529 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(C)C InChI=1S/C19H22ClN3O4S/c1-12(18(24)22(2)3)23-9-8-17(19(23)25)21-28(26,27)16-7-5-13-10-15(20)6-4-14(13)11-16/h4-7,10-12,17,21H,8-9H2,1-3H3/t12-,17-/m0/s1 IKUIMFDSERPHCP-SJCJKPOMSA-N 12499 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N,N-dimethylpropanamide::P4 alanylamide pyrrolidin-2-one 11 Coagulation factor X Homo sapiens 346 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12499&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646108 46512959 ZINC14949932 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22530 CCN(C)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C20H24ClN3O4S/c1-4-23(3)19(25)13(2)24-10-9-18(20(24)26)22-29(27,28)17-8-6-14-11-16(21)7-5-15(14)12-17/h5-8,11-13,18,22H,4,9-10H2,1-3H3/t13-,18-/m0/s1 XKHSALHGHSVJEN-UGSOOPFHSA-N 12501 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-ethyl-N-methylpropanamide::P4 alanylamide pyrrolidin-2-one 12 Coagulation factor X Homo sapiens 56 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12501&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646109 46512960 ZINC14949935 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22531 CCN(CC)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C21H26ClN3O4S/c1-4-24(5-2)20(26)14(3)25-11-10-19(21(25)27)23-30(28,29)18-9-7-15-12-17(22)8-6-16(15)13-18/h6-9,12-14,19,23H,4-5,10-11H2,1-3H3/t14-,19-/m0/s1 GTCVDLXSZXKQCY-LIRRHRJNSA-N 12502 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N,N-diethylpropanamide::P4 alanylamide pyrrolidin-2-one 13 Coagulation factor X Homo sapiens 24 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12502&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10151574 46512961 ZINC14949938 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22532 CC(C)NC(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C20H24ClN3O4S/c1-12(2)22-19(25)13(3)24-9-8-18(20(24)26)23-29(27,28)17-7-5-14-10-16(21)6-4-15(14)11-17/h4-7,10-13,18,23H,8-9H2,1-3H3,(H,22,25)/t13-,18-/m0/s1 NMPGSBDMLORZBL-UGSOOPFHSA-N 12503 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 14 Coagulation factor X Homo sapiens 2720 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12503&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646110 46512962 ZINC14949941 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22533 CC(C)N(C)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C21H26ClN3O4S/c1-13(2)24(4)20(26)14(3)25-10-9-19(21(25)27)23-30(28,29)18-8-6-15-11-17(22)7-5-16(15)12-18/h5-8,11-14,19,23H,9-10H2,1-4H3/t14-,19-/m0/s1 SGVNEUCOHOZPOT-LIRRHRJNSA-N 12504 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-methyl-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 15 Coagulation factor X Homo sapiens 22 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12504&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646111 46512963 ZINC14949943 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22534 CCN(C(C)C)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C22H28ClN3O4S/c1-5-25(14(2)3)21(27)15(4)26-11-10-20(22(26)28)24-31(29,30)19-9-7-16-12-18(23)8-6-17(16)13-19/h6-9,12-15,20,24H,5,10-11H2,1-4H3/t15-,20-/m0/s1 HLQIJPDUFSPOBV-YWZLYKJASA-N 12505 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-ethyl-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 16 Coagulation factor X Homo sapiens 11 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12505&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10195400 46512964 ZINC14949946 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22535 CC(C)N(CCC#N)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C23H27ClN4O4S/c1-15(2)27(11-4-10-25)22(29)16(3)28-12-9-21(23(28)30)26-33(31,32)20-8-6-17-13-19(24)7-5-18(17)14-20/h5-8,13-16,21,26H,4,9,11-12H2,1-3H3/t16-,21-/m0/s1 NNJMHYPCMMVMED-KKSFZXQISA-N 12506 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(2-cyanoethyl)-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 17 Coagulation factor X Homo sapiens 5 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12506&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10217652 46512965 ZINC14949949 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24850 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2cccc3ccccc23)c1 InChI=1S/C28H24N4O2/c29-27(30)20-9-3-6-18(14-20)17-32-24-12-5-13-26(33)23(24)15-25(32)28(34)31-16-21-10-4-8-19-7-1-2-11-22(19)21/h1-15,33H,16-17H2,(H3,29,30)(H,31,34) FUDJBRQKKDTOFI-UHFFFAOYSA-N 13840 1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-N-(naphthalen-1-ylmethyl)-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 24 Coagulation factor X Homo sapiens 68 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13840&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10950398 46514219 ZINC03831860 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24851 Cc1cccc2n(Cc3cccc(c3)C(N)=N)c(cc12)C(=O)NCc1cc[n+]([O-])cc1 InChI=1S/C24H23N5O2/c1-16-4-2-7-21-20(16)13-22(24(30)27-14-17-8-10-28(31)11-9-17)29(21)15-18-5-3-6-19(12-18)23(25)26/h2-13H,14-15H2,1H3,(H3,25,26)(H,27,30) UJOHKFWDSQICJW-UHFFFAOYSA-N 13841 2,2,2-trifluoroacetic acid; 4-[({1-[(3-carbamimidoylphenyl)methyl]-4-methyl-1H-indol-2-yl}formamido)methyl]-1-oxidopyridin-1-ium::3-amidinobenzylindole carboxamide 25 Coagulation factor X Homo sapiens 14480 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13841&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10875093 46514220 ZINC13474305 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24852 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCCc2ccc(Cl)c(Cl)c2)c1 InChI=1S/C25H22Cl2N4O2/c26-19-8-7-15(12-20(19)27)9-10-30-25(33)22-13-18-21(5-2-6-23(18)32)31(22)14-16-3-1-4-17(11-16)24(28)29/h1-8,11-13,32H,9-10,14H2,(H3,28,29)(H,30,33) CHROGWSHBDHTME-UHFFFAOYSA-N 13842 1-[(3-carbamimidoylphenyl)methyl]-N-[2-(3,4-dichlorophenyl)ethyl]-4-hydroxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 26 Coagulation factor X Homo sapiens 918 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13842&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11005350 46514221 ZINC13474306 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24853 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCCc2cccc(Cl)c2)c1 InChI=1S/C25H23ClN4O2/c26-19-7-2-4-16(13-19)10-11-29-25(32)22-14-20-21(8-3-9-23(20)31)30(22)15-17-5-1-6-18(12-17)24(27)28/h1-9,12-14,31H,10-11,15H2,(H3,27,28)(H,29,32) DLPDPMIATLUAQK-UHFFFAOYSA-N 13843 1-[(3-carbamimidoylphenyl)methyl]-N-[2-(3-chlorophenyl)ethyl]-4-hydroxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 27::CHEMBL310717 Coagulation factor X Homo sapiens 707 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13843&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11134090 46514222 CHEMBL310717 ZINC03831915 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24854 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCCc2ccc(Br)cc2)c1 InChI=1S/C25H23BrN4O2/c26-19-9-7-16(8-10-19)11-12-29-25(32)22-14-20-21(5-2-6-23(20)31)30(22)15-17-3-1-4-18(13-17)24(27)28/h1-10,13-14,31H,11-12,15H2,(H3,27,28)(H,29,32) UKJQBFOVSLOHKL-UHFFFAOYSA-N 13844 3-amidinobenzylindole carboxamide 28::N-[2-(4-bromophenyl)ethyl]-1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 1628 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13844&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11071021 46514223 ZINC03831864 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24856 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCCc2ccc(Cl)cc2)c1 InChI=1S/C25H23ClN4O2/c26-19-9-7-16(8-10-19)11-12-29-25(32)22-14-20-21(5-2-6-23(20)31)30(22)15-17-3-1-4-18(13-17)24(27)28/h1-10,13-14,31H,11-12,15H2,(H3,27,28)(H,29,32) FHMVRFONCOJJPE-UHFFFAOYSA-N 13845 1-[(3-carbamimidoylphenyl)methyl]-N-[2-(4-chlorophenyl)ethyl]-4-hydroxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 29 Coagulation factor X Homo sapiens 1556 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13845&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10884798 46514224 ZINC03831914 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24857 COc1cccc2n(Cc3cccc(c3)C(N)=N)c(cc12)C(=O)NCCc1ccc(O)cc1 InChI=1S/C26H26N4O3/c1-33-24-7-3-6-22-21(24)15-23(26(32)29-13-12-17-8-10-20(31)11-9-17)30(22)16-18-4-2-5-19(14-18)25(27)28/h2-11,14-15,31H,12-13,16H2,1H3,(H3,27,28)(H,29,32) XDQPYGTXENDOLI-UHFFFAOYSA-N 13846 1-[(3-carbamimidoylphenyl)methyl]-N-[2-(4-hydroxyphenyl)ethyl]-4-methoxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 30 Coagulation factor X Homo sapiens 970 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13846&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11091496 46514225 ZINC03815851 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24858 CN(CCNC(=O)c1cc2c(O)cccc2n1Cc1cccc(c1)C(N)=N)c1cccc2ccccc12 InChI=1S/C30H29N5O2/c1-34(25-12-5-9-21-8-2-3-11-23(21)25)16-15-33-30(37)27-18-24-26(13-6-14-28(24)36)35(27)19-20-7-4-10-22(17-20)29(31)32/h2-14,17-18,36H,15-16,19H2,1H3,(H3,31,32)(H,33,37) YISRVMZSILAUFZ-UHFFFAOYSA-N 13847 1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-N-{2-[methyl(naphthalen-1-yl)amino]ethyl}-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 31 Coagulation factor X Homo sapiens 2470 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13847&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646531 46514226 ZINC13474307 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24859 C[n+]1ccc(CCNC(=O)c2cc3ccccc3n2Cc2cccc(c2)C(N)=N)cc1 InChI=1S/C25H25N5O/c1-29-13-10-18(11-14-29)9-12-28-25(31)23-16-20-6-2-3-8-22(20)30(23)17-19-5-4-7-21(15-19)24(26)27/h2-8,10-11,13-16H,9,12,17H2,1H3,(H3-,26,27,28,31)/p+1 CHPYDCXPEIVQRM-UHFFFAOYSA-O 13848 2,2,2-trifluoroacetate; 4-[2-({1-[(3-carbamimidoylphenyl)methyl]-1H-indol-2-yl}formamido)ethyl]-1-methylpyridin-1-ium::3-amidinobenzylindole carboxamide 32 Coagulation factor X Homo sapiens 1300 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13848&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9958478 46514227 ZINC12355153 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24860 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCCNc2cccc3ccccc23)c1 InChI=1S/C29H27N5O2/c30-28(31)21-9-3-6-19(16-21)18-34-25-12-5-13-27(35)23(25)17-26(34)29(36)33-15-14-32-24-11-4-8-20-7-1-2-10-22(20)24/h1-13,16-17,32,35H,14-15,18H2,(H3,30,31)(H,33,36) KKPAJDHNRKNUIT-UHFFFAOYSA-N 13849 1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-N-[2-(naphthalen-1-ylamino)ethyl]-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 33 Coagulation factor X Homo sapiens 318 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13849&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11113557 46514228 ZINC13474308 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24861 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2cc(Cl)cc(Cl)c2Cl)c1 InChI=1S/C24H19Cl3N4O2/c25-16-8-15(22(27)18(26)9-16)11-30-24(33)20-10-17-19(5-2-6-21(17)32)31(20)12-13-3-1-4-14(7-13)23(28)29/h1-10,32H,11-12H2,(H3,28,29)(H,30,33) ATSROBXXNRWKDL-UHFFFAOYSA-N 13850 1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-N-[(2,3,5-trichlorophenyl)methyl]-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 34 Coagulation factor X Homo sapiens 99 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13850&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10885612 46514229 ZINC03831872 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24862 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCCc2ccc(Cl)cc2Cl)c1 InChI=1S/C25H22Cl2N4O2/c26-18-8-7-16(20(27)12-18)9-10-30-25(33)22-13-19-21(5-2-6-23(19)32)31(22)14-15-3-1-4-17(11-15)24(28)29/h1-8,11-13,32H,9-10,14H2,(H3,28,29)(H,30,33) HPTKLWGAXJIUCD-UHFFFAOYSA-N 13851 1-[(3-carbamimidoylphenyl)methyl]-N-[2-(2,4-dichlorophenyl)ethyl]-4-hydroxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 35 Coagulation factor X Homo sapiens 840 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13851&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10928936 46514230 ZINC13474309 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24863 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2ccccc2Cl)c1 InChI=1S/C24H21ClN4O2/c25-19-8-2-1-6-17(19)13-28-24(31)21-12-18-20(9-4-10-22(18)30)29(21)14-15-5-3-7-16(11-15)23(26)27/h1-12,30H,13-14H2,(H3,26,27)(H,28,31) SGJDMUGIHITLIK-UHFFFAOYSA-N 13852 1-[(3-carbamimidoylphenyl)methyl]-N-[(2-chlorophenyl)methyl]-4-hydroxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 36 Coagulation factor X Homo sapiens 1200 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13852&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11112866 46514231 ZINC03833789 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24864 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2ccc3ccccc3c2)c1 InChI=1S/C28H24N4O2/c29-27(30)22-8-3-5-19(14-22)17-32-24-9-4-10-26(33)23(24)15-25(32)28(34)31-16-18-11-12-20-6-1-2-7-21(20)13-18/h1-15,33H,16-17H2,(H3,29,30)(H,31,34) JJTQSSVDILCXCV-UHFFFAOYSA-N 13853 1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-N-(naphthalen-2-ylmethyl)-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 37 Coagulation factor X Homo sapiens 1720 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13853&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10863260 46514232 ZINC03831907 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24865 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2ccc(Cl)c(Cl)c2)c1 InChI=1S/C24H20Cl2N4O2/c25-18-8-7-14(10-19(18)26)12-29-24(32)21-11-17-20(5-2-6-22(17)31)30(21)13-15-3-1-4-16(9-15)23(27)28/h1-11,31H,12-13H2,(H3,27,28)(H,29,32) ZYSSITBAMVZEII-UHFFFAOYSA-N 13854 1-[(3-carbamimidoylphenyl)methyl]-N-[(3,4-dichlorophenyl)methyl]-4-hydroxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 38 Coagulation factor X Homo sapiens 841 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13854&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11102698 46514233 ZINC03831859 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24866 COc1ccc(CNC(=O)c2cc3c(O)cccc3n2Cc2cccc(c2)C(N)=N)cc1OC InChI=1S/C26H26N4O4/c1-33-23-10-9-16(12-24(23)34-2)14-29-26(32)21-13-19-20(7-4-8-22(19)31)30(21)15-17-5-3-6-18(11-17)25(27)28/h3-13,31H,14-15H2,1-2H3,(H3,27,28)(H,29,32) BYJOJJLFQJBUAV-UHFFFAOYSA-N 13855 1-[(3-carbamimidoylphenyl)methyl]-N-[(3,4-dimethoxyphenyl)methyl]-4-hydroxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 39 Coagulation factor X Homo sapiens 17350 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13855&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11037845 46514234 ZINC03831837 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24867 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1 InChI=1S/C26H20F6N4O2/c27-25(28,29)17-8-15(9-18(10-17)26(30,31)32)12-35-24(38)21-11-19-20(5-2-6-22(19)37)36(21)13-14-3-1-4-16(7-14)23(33)34/h1-11,37H,12-13H2,(H3,33,34)(H,35,38) SCROZWCCSPRDIO-UHFFFAOYSA-N 13856 3-amidinobenzylindole carboxamide 40::N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 99 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13856&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11731179 46514235 ZINC03831909 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24868 Cc1cccc2n(Cc3cccc(c3)C(N)=N)c(cc12)C(=O)NCc1cc(Cl)cc(Cl)c1 InChI=1S/C25H22Cl2N4O/c1-15-4-2-7-22-21(15)12-23(25(32)30-13-17-9-19(26)11-20(27)10-17)31(22)14-16-5-3-6-18(8-16)24(28)29/h2-12H,13-14H2,1H3,(H3,28,29)(H,30,32) YAAKSJLUBVPBIM-UHFFFAOYSA-N 12402 1-[(3-carbamimidoylphenyl)methyl]-N-[(3,5-dichlorophenyl)methyl]-4-methyl-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 47::3-amidinobenzylindole carboxamide 41 Coagulation factor X Homo sapiens 25 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12402&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search CMB 1LPZ 446982 46512871 ZINC02047778 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24869 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)Nc2cc(Cl)cc(Cl)c2)c1 InChI=1S/C23H18Cl2N4O2/c24-15-8-16(25)10-17(9-15)28-23(31)20-11-18-19(5-2-6-21(18)30)29(20)12-13-3-1-4-14(7-13)22(26)27/h1-11,30H,12H2,(H3,26,27)(H,28,31) FPRKQCJSMUAPDV-UHFFFAOYSA-N 13858 1-[(3-carbamimidoylphenyl)methyl]-N-(3,5-dichlorophenyl)-4-hydroxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 42::CHEMBL308510 Coagulation factor X Homo sapiens 798 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13858&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10884908 46514236 CHEMBL308510 ZINC03831868 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24873 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2cc(F)cc(F)c2)c1 InChI=1S/C24H20F2N4O2/c25-17-8-15(9-18(26)10-17)12-29-24(32)21-11-19-20(5-2-6-22(19)31)30(21)13-14-3-1-4-16(7-14)23(27)28/h1-11,31H,12-13H2,(H3,27,28)(H,29,32) MQWWPLRRKVLBON-UHFFFAOYSA-N 13859 1-[(3-carbamimidoylphenyl)methyl]-N-[(3,5-difluorophenyl)methyl]-4-hydroxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 43 Coagulation factor X Homo sapiens 191 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13859&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11732813 46514237 ZINC03831923 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24874 COc1cc(CNC(=O)c2cc3c(O)cccc3n2Cc2cccc(c2)C(N)=N)cc(OC)c1 InChI=1S/C26H26N4O4/c1-33-19-10-17(11-20(12-19)34-2)14-29-26(32)23-13-21-22(7-4-8-24(21)31)30(23)15-16-5-3-6-18(9-16)25(27)28/h3-13,31H,14-15H2,1-2H3,(H3,27,28)(H,29,32) IDZYCWBZDALJHR-UHFFFAOYSA-N 13860 1-[(3-carbamimidoylphenyl)methyl]-N-[(3,5-dimethoxyphenyl)methyl]-4-hydroxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 44 Coagulation factor X Homo sapiens 193 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13860&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11102544 46514238 ZINC03831879 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24875 Cc1cc(C)cc(CNC(=O)c2cc3c(C)cccc3n2Cc2cccc(c2)C(N)=N)c1 InChI=1S/C27H28N4O/c1-17-10-18(2)12-21(11-17)15-30-27(32)25-14-23-19(3)6-4-9-24(23)31(25)16-20-7-5-8-22(13-20)26(28)29/h4-14H,15-16H2,1-3H3,(H3,28,29)(H,30,32) JSQZLEYFOOSZPU-UHFFFAOYSA-N 13861 1-[(3-carbamimidoylphenyl)methyl]-N-[(3,5-dimethylphenyl)methyl]-4-methyl-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 45 Coagulation factor X Homo sapiens 9 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13861&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search CMI 1LQD 446984 46514239 ZINC01490443 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24876 Cc1cc(C)cc(CNC(=O)c2cc3c(O)cccc3n2Cc2cccc(c2)C(N)=N)c1 InChI=1S/C26H26N4O2/c1-16-9-17(2)11-19(10-16)14-29-26(32)23-13-21-22(7-4-8-24(21)31)30(23)15-18-5-3-6-20(12-18)25(27)28/h3-13,31H,14-15H2,1-2H3,(H3,27,28)(H,29,32) FUDFVURUAYZCCL-UHFFFAOYSA-N 13862 1-[(3-carbamimidoylphenyl)methyl]-N-[(3,5-dimethylphenyl)methyl]-4-hydroxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 46::CHEMBL307196 Coagulation factor X Homo sapiens 11 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13862&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10071127 46514240 CHEMBL307196 ZINC03831906 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24877 Cc1cccc2n(Cc3cccc(c3)C(N)=N)c(cc12)C(=O)NCc1cccc(c1)C(N)=N InChI=1S/C26H26N6O/c1-16-5-2-10-22-21(16)13-23(32(22)15-18-7-4-9-20(12-18)25(29)30)26(33)31-14-17-6-3-8-19(11-17)24(27)28/h2-13H,14-15H2,1H3,(H3,27,28)(H3,29,30)(H,31,33) FNQKXHHOHZTUGP-UHFFFAOYSA-N 13863 3-amidinobenzylindole carboxamide 47::N,1-bis[(3-carbamimidoylphenyl)methyl]-4-methyl-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 7 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13863&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10343097 46514241 ZINC01490441 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24878 NC(=N)c1cccc(COC(=O)c2cc3cc(OCc4ccccc4)ccc3n2Cc2cccc(c2)C(N)=N)c1 InChI=1S/C32H29N5O3/c33-30(34)24-10-4-8-22(14-24)18-37-28-13-12-27(39-19-21-6-2-1-3-7-21)16-26(28)17-29(37)32(38)40-20-23-9-5-11-25(15-23)31(35)36/h1-17H,18-20H2,(H3,33,34)(H3,35,36) MEZAUPCCMVATCJ-UHFFFAOYSA-N 13864 (3-carbamimidoylphenyl)methyl 5-(benzyloxy)-1-[(3-carbamimidoylphenyl)methyl]-1H-indole-2-carboxylate::3-amidinobenzylindole carboxamide 48 Coagulation factor X Homo sapiens 61 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13864&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11082011 46514242 ZINC03831843 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24879 NC(=N)c1cccc(CNC(=O)c2cc3cc(N)ccc3n2Cc2cccc(c2)C(N)=N)c1 InChI=1S/C25H25N7O/c26-20-7-8-21-19(11-20)12-22(32(21)14-16-4-2-6-18(10-16)24(29)30)25(33)31-13-15-3-1-5-17(9-15)23(27)28/h1-12H,13-14,26H2,(H3,27,28)(H3,29,30)(H,31,33) IXDNONYWPHTGPP-UHFFFAOYSA-N 13865 3-amidinobenzylindole carboxamide 49::5-amino-N,1-bis[(3-carbamimidoylphenyl)methyl]-1H-indole-2-carboxamide::CHEMBL307201 Coagulation factor X Homo sapiens 51 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13865&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11826299 46514243 CHEMBL307201 ZINC13474310 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24880 NC(=N)c1cccc(CNC(=O)c2cc3c(O)cccc3n2Cc2cccc(c2)C(N)=N)c1 InChI=1S/C25H24N6O2/c26-23(27)17-6-1-4-15(10-17)13-30-25(33)21-12-19-20(8-3-9-22(19)32)31(21)14-16-5-2-7-18(11-16)24(28)29/h1-12,32H,13-14H2,(H3,26,27)(H3,28,29)(H,30,33) MTIISILSXHNZMT-UHFFFAOYSA-N 13866 3-amidinobenzylindole carboxamide 50::CHEMBL307446::N,1-bis[(3-carbamimidoylphenyl)methyl]-4-hydroxy-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 9 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13866&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11048452 46514244 CHEMBL307446 ZINC02007314 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24881 NC(=N)c1cccc(CNC(=O)c2cc3cc(O)ccc3n2Cc2cccc(c2)C(N)=N)c1 InChI=1S/C25H24N6O2/c26-23(27)17-5-1-3-15(9-17)13-30-25(33)22-12-19-11-20(32)7-8-21(19)31(22)14-16-4-2-6-18(10-16)24(28)29/h1-12,32H,13-14H2,(H3,26,27)(H3,28,29)(H,30,33) WQMLURUPDYUIKJ-UHFFFAOYSA-N 13867 3-amidinobenzylindole carboxamide 51::N,1-bis[(3-carbamimidoylphenyl)methyl]-5-hydroxy-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 77 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13867&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11070239 46514245 ZINC04631092 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24882 NC(=N)c1cccc(CNC(=O)c2cc3cc(OCc4ccccc4)ccc3n2Cc2cccc(c2)C(N)=N)c1 InChI=1S/C32H30N6O2/c33-30(34)24-10-4-8-22(14-24)18-37-32(39)29-17-26-16-27(40-20-21-6-2-1-3-7-21)12-13-28(26)38(29)19-23-9-5-11-25(15-23)31(35)36/h1-17H,18-20H2,(H3,33,34)(H3,35,36)(H,37,39) DMUWRNDTNGVXSO-UHFFFAOYSA-N 13868 3-amidinobenzylindole carboxamide 52::5-(benzyloxy)-N,1-bis[(3-carbamimidoylphenyl)methyl]-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 133 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13868&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10907552 46514246 ZINC03815857 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24883 NC(=N)c1cccc(CNC(=O)c2cc3ccccc3n2Cc2cccc(c2)C(N)=N)c1 InChI=1S/C25H24N6O/c26-23(27)19-8-3-5-16(11-19)14-30-25(32)22-13-18-7-1-2-10-21(18)31(22)15-17-6-4-9-20(12-17)24(28)29/h1-13H,14-15H2,(H3,26,27)(H3,28,29)(H,30,32) CILOPWAVWPMHMN-UHFFFAOYSA-N 13869 3-amidinobenzylindole carboxamide 53::N,1-bis[(3-carbamimidoylphenyl)methyl]-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 19 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13869&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10884388 46514247 ZINC03831806 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24884 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2cccc(Br)c2)c1 InChI=1S/C24H21BrN4O2/c25-18-7-2-4-15(11-18)13-28-24(31)21-12-19-20(8-3-9-22(19)30)29(21)14-16-5-1-6-17(10-16)23(26)27/h1-12,30H,13-14H2,(H3,26,27)(H,28,31) WYVSCRWJUBTFKJ-UHFFFAOYSA-N 13870 3-amidinobenzylindole carboxamide 55::N-[(3-bromophenyl)methyl]-1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 117 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13870&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11123629 46514248 ZINC03831880 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24885 NC(=O)Nc1cccc(CNC(=O)c2cc3c(O)cccc3n2Cc2cccc(c2)C(N)=N)c1 InChI=1S/C25H24N6O3/c26-23(27)17-6-1-5-16(10-17)14-31-20-8-3-9-22(32)19(20)12-21(31)24(33)29-13-15-4-2-7-18(11-15)30-25(28)34/h1-12,32H,13-14H2,(H3,26,27)(H,29,33)(H3,28,30,34) KPCOGFMAXWTPAG-UHFFFAOYSA-N 13871 1-[(3-carbamimidoylphenyl)methyl]-N-{[3-(carbamoylamino)phenyl]methyl}-4-hydroxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 56 Coagulation factor X Homo sapiens 180 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13871&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646532 46514249 ZINC03831877 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24891 NC(=N)c1cccc(Cn2c(cc3ccccc23)C(=O)NCc2cccc(c2)C(N)=O)c1 InChI=1S/C25H23N5O2/c26-23(27)19-8-4-6-17(12-19)15-30-21-10-2-1-7-18(21)13-22(30)25(32)29-14-16-5-3-9-20(11-16)24(28)31/h1-13H,14-15H2,(H3,26,27)(H2,28,31)(H,29,32) NGXRQPCJQRLNMU-UHFFFAOYSA-N 13872 1-[(3-carbamimidoylphenyl)methyl]-N-[(3-carbamoylphenyl)methyl]-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 57 Coagulation factor X Homo sapiens 240 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13872&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11112713 46514250 ZINC03831875 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24892 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2cccc(Cl)c2)c1 InChI=1S/C24H21ClN4O2/c25-18-7-2-4-15(11-18)13-28-24(31)21-12-19-20(8-3-9-22(19)30)29(21)14-16-5-1-6-17(10-16)23(26)27/h1-12,30H,13-14H2,(H3,26,27)(H,28,31) NKDGHZPUEJJHPY-UHFFFAOYSA-N 13873 1-[(3-carbamimidoylphenyl)methyl]-N-[(3-chlorophenyl)methyl]-4-hydroxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 58::CHEMBL307846 Coagulation factor X Homo sapiens 262 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13873&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10873723 46514251 CHEMBL307846 ZINC03831863 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24893 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2cc(F)cc(c2)C(F)(F)F)c1 InChI=1S/C25H20F4N4O2/c26-18-9-15(8-17(10-18)25(27,28)29)12-32-24(35)21-11-19-20(5-2-6-22(19)34)33(21)13-14-3-1-4-16(7-14)23(30)31/h1-11,34H,12-13H2,(H3,30,31)(H,32,35) GQXDHJRJUQVDDX-UHFFFAOYSA-N 13874 1-[(3-carbamimidoylphenyl)methyl]-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-4-hydroxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 59 Coagulation factor X Homo sapiens 39 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13874&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10972928 46514252 ZINC03831881 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24894 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2cccc(F)c2)c1 InChI=1S/C24H21FN4O2/c25-18-7-2-4-15(11-18)13-28-24(31)21-12-19-20(8-3-9-22(19)30)29(21)14-16-5-1-6-17(10-16)23(26)27/h1-12,30H,13-14H2,(H3,26,27)(H,28,31) MTNBCPMEMDPUIE-UHFFFAOYSA-N 13875 1-[(3-carbamimidoylphenyl)methyl]-N-[(3-fluorophenyl)methyl]-4-hydroxy-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 60 Coagulation factor X Homo sapiens 720 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13875&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10927859 46514253 ZINC03831841 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24895 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2cccc(c2)C(O)=O)c1 InChI=1S/C25H22N4O4/c26-23(27)17-6-2-5-16(11-17)14-29-20-8-3-9-22(30)19(20)12-21(29)24(31)28-13-15-4-1-7-18(10-15)25(32)33/h1-12,30H,13-14H2,(H3,26,27)(H,28,31)(H,32,33) OKLNPTWIQIJRDB-UHFFFAOYSA-N 13876 3-[({1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-1H-indol-2-yl}formamido)methyl]benzoic acid::3-amidinobenzylindole carboxamide 61 Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13876&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11048482 46514254 ZINC08552715 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24896 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2cccc(I)c2)c1 InChI=1S/C24H21IN4O2/c25-18-7-2-4-15(11-18)13-28-24(31)21-12-19-20(8-3-9-22(19)30)29(21)14-16-5-1-6-17(10-16)23(26)27/h1-12,30H,13-14H2,(H3,26,27)(H,28,31) UVACBIWKEUYYBF-UHFFFAOYSA-N 13877 1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-N-[(3-iodophenyl)methyl]-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 62 Coagulation factor X Homo sapiens 42 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13877&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10896662 46514255 ZINC03831910 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24897 COc1cccc(CNC(=O)c2cc3c(O)cccc3n2Cc2cccc(c2)C(N)=N)c1 InChI=1S/C25H24N4O3/c1-32-19-8-3-5-16(12-19)14-28-25(31)22-13-20-21(9-4-10-23(20)30)29(22)15-17-6-2-7-18(11-17)24(26)27/h2-13,30H,14-15H2,1H3,(H3,26,27)(H,28,31) KFNZTJQJAFKCIV-UHFFFAOYSA-N 13878 1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-N-[(3-methoxyphenyl)methyl]-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 63 Coagulation factor X Homo sapiens 308 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13878&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11080476 46514256 ZINC03815849 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24898 COC(=O)c1cccc(CNC(=O)c2cc3c(O)cccc3n2Cc2cccc(c2)C(N)=N)c1 InChI=1S/C26H24N4O4/c1-34-26(33)19-8-2-5-16(11-19)14-29-25(32)22-13-20-21(9-4-10-23(20)31)30(22)15-17-6-3-7-18(12-17)24(27)28/h2-13,31H,14-15H2,1H3,(H3,27,28)(H,29,32) CMQOCVCCCMZPAD-UHFFFAOYSA-N 13879 3-amidinobenzylindole carboxamide 64::methyl 3-[({1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-1H-indol-2-yl}formamido)methyl]benzoate Coagulation factor X Homo sapiens 2043 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13879&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11037810 46514257 ZINC03833792 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24899 Cc1cc(CNC(=O)c2cc3c(O)cccc3n2Cc2cccc(c2)C(N)=N)cc(c1)C(F)(F)F InChI=1S/C26H23F3N4O2/c1-15-8-17(11-19(9-15)26(27,28)29)13-32-25(35)22-12-20-21(6-3-7-23(20)34)33(22)14-16-4-2-5-18(10-16)24(30)31/h2-12,34H,13-14H2,1H3,(H3,30,31)(H,32,35) KGJMNJQHRNGVAG-UHFFFAOYSA-N 13880 1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-N-{[3-methyl-5-(trifluoromethyl)phenyl]methyl}-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 65 Coagulation factor X Homo sapiens 13 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13880&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10896126 46514258 ZINC03831883 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24900 Cc1cccc(CNC(=O)c2cc3c(O)cccc3n2Cc2cccc(c2)C(N)=N)c1 InChI=1S/C25H24N4O2/c1-16-5-2-6-17(11-16)14-28-25(31)22-13-20-21(9-4-10-23(20)30)29(22)15-18-7-3-8-19(12-18)24(26)27/h2-13,30H,14-15H2,1H3,(H3,26,27)(H,28,31) GHCFFSHLCKHAEO-UHFFFAOYSA-N 13881 1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-N-[(3-methylphenyl)methyl]-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 66::CHEMBL76987 Coagulation factor X Homo sapiens 131 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13881&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10949672 46514259 CHEMBL76987 ZINC03831833 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24901 Cc1cccc2n(Cc3cccc(c3)C(N)=N)c(cc12)C(=O)NCc1cccc(c1)[N+]([O-])=O InChI=1S/C25H23N5O3/c1-16-5-2-10-22-21(16)13-23(29(22)15-18-7-3-8-19(11-18)24(26)27)25(31)28-14-17-6-4-9-20(12-17)30(32)33/h2-13H,14-15H2,1H3,(H3,26,27)(H,28,31) WTHMBUSTJLZMDE-UHFFFAOYSA-N 13882 1-[(3-carbamimidoylphenyl)methyl]-4-methyl-N-[(3-nitrophenyl)methyl]-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 67 Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13882&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10863119 46514260 ZINC03831871 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24902 NC(=N)c1cccc(Cn2c(cc3c(O)cccc23)C(=O)NCc2cccc(c2)C(F)(F)F)c1 InChI=1S/C25H21F3N4O2/c26-25(27,28)18-7-2-4-15(11-18)13-31-24(34)21-12-19-20(8-3-9-22(19)33)32(21)14-16-5-1-6-17(10-16)23(29)30/h1-12,33H,13-14H2,(H3,29,30)(H,31,34) SSASEQUXDAXXPK-UHFFFAOYSA-N 13883 1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-N-{[3-(trifluoromethyl)phenyl]methyl}-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 68 Coagulation factor X Homo sapiens 476 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13883&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11102680 46514261 ZINC03831913 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24903 Cc1c(F)ccc2n(Cc3cccc(c3)C(N)=N)c(cc12)C(=O)NCc1ccc(cc1)[N+](C)(C)Cc1ccccc1 InChI=1S/C34H34FN5O/c1-23-29-19-32(39(31(29)17-16-30(23)35)21-26-10-7-11-27(18-26)33(36)37)34(41)38-20-24-12-14-28(15-13-24)40(2,3)22-25-8-5-4-6-9-25/h4-19H,20-22H2,1-3H3,(H3-,36,37,38,41)/p+1 SFFPYZNRYZUJGI-UHFFFAOYSA-O 13884 2,2,2-trifluoroacetate; N-benzyl-4-[({1-[(3-carbamimidoylphenyl)methyl]-5-fluoro-4-methyl-1H-indol-2-yl}formamido)methyl]-N,N-dimethylanilinium::3-amidinobenzylindole carboxamide 69 Coagulation factor X Homo sapiens 245 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13884&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11082882 46514262 C08037 ZINC14954012 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24904 Cc1cccc2n(Cc3cccc(c3)C(N)=N)c(cc12)C(=O)NCc1ccc(cc1)[N+](C)(C)Cc1ccccc1 InChI=1S/C34H35N5O/c1-24-9-7-14-31-30(24)20-32(38(31)22-27-12-8-13-28(19-27)33(35)36)34(40)37-21-25-15-17-29(18-16-25)39(2,3)23-26-10-5-4-6-11-26/h4-20H,21-23H2,1-3H3,(H3-,35,36,37,40)/p+1 AREGJMORGJFWDY-UHFFFAOYSA-O 13885 2,2,2-trifluoroacetate; N-benzyl-4-[({1-[(3-carbamimidoylphenyl)methyl]-4-methyl-1H-indol-2-yl}formamido)methyl]-N,N-dimethylanilinium::3-amidinobenzylindole carboxamide 70 Coagulation factor X Homo sapiens 23 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13885&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10897551 46514263 C08037 ZINC13474311 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24908 CN(C)c1ccc(CNC(=O)c2cc3c(C)cccc3n2Cc2cccc(c2)C(N)=N)cc1 InChI=1S/C27H29N5O/c1-18-6-4-9-24-23(18)15-25(32(24)17-20-7-5-8-21(14-20)26(28)29)27(33)30-16-19-10-12-22(13-11-19)31(2)3/h4-15H,16-17H2,1-3H3,(H3,28,29)(H,30,33) PRIRHEBPAJTNLS-UHFFFAOYSA-N 13886 1-[(3-carbamimidoylphenyl)methyl]-N-{[4-(dimethylamino)phenyl]methyl}-4-methyl-1H-indole-2-carboxamide; 2,2,2-trifluoroacetic acid::3-amidinobenzylindole carboxamide 71 Coagulation factor X Homo sapiens 1310 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13886&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11028062 46514264 ZINC13474312 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24909 CN(C)c1ccc(CNC(=O)c2cc3cc(F)ccc3n2Cc2cccc(c2)C(N)=N)cc1 InChI=1S/C26H26FN5O/c1-31(2)22-9-6-17(7-10-22)15-30-26(33)24-14-20-13-21(27)8-11-23(20)32(24)16-18-4-3-5-19(12-18)25(28)29/h3-14H,15-16H2,1-2H3,(H3,28,29)(H,30,33) KCIYEKHGUZISEW-UHFFFAOYSA-N 13887 1-[(3-carbamimidoylphenyl)methyl]-N-{[4-(dimethylamino)phenyl]methyl}-5-fluoro-1H-indole-2-carboxamide; 2,2,2-trifluoroacetic acid::3-amidinobenzylindole carboxamide 72 Coagulation factor X Homo sapiens 3520 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13887&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11146105 46514265 ZINC13474313 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24910 CC[N+](C)(C)c1ccc(CNC(=O)c2cc3cc(F)ccc3n2Cc2cccc(c2)C(N)=N)cc1 InChI=1S/C28H30FN5O/c1-4-34(2,3)24-11-8-19(9-12-24)17-32-28(35)26-16-22-15-23(29)10-13-25(22)33(26)18-20-6-5-7-21(14-20)27(30)31/h5-16H,4,17-18H2,1-3H3,(H3-,30,31,32,35)/p+1 JYNWGVLVJLZPQG-UHFFFAOYSA-O 13888 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-5-fluoro-1H-indol-2-yl}formamido)methyl]-N-ethyl-N,N-dimethylanilinium::3-amidinobenzylindole carboxamide 73 Coagulation factor X Homo sapiens 103 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13888&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11828044 46514266 ZINC13474314 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24911 C[N+](C)(CC=C)c1ccc(CNC(=O)c2cc3cc(F)ccc3n2Cc2cccc(c2)C(N)=N)cc1 InChI=1S/C29H30FN5O/c1-4-14-35(2,3)25-11-8-20(9-12-25)18-33-29(36)27-17-23-16-24(30)10-13-26(23)34(27)19-21-6-5-7-22(15-21)28(31)32/h4-13,15-17H,1,14,18-19H2,2-3H3,(H3-,31,32,33,36)/p+1 DWHJINUSNMWELD-UHFFFAOYSA-O 13889 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-5-fluoro-1H-indol-2-yl}formamido)methyl]-N,N-dimethyl-N-(prop-2-en-1-yl)anilinium::3-amidinobenzylindole carboxamide 74 Coagulation factor X Homo sapiens 141 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13889&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11135735 46514267 ZINC13474315 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24912 C[N+](C)(CC#C)c1ccc(CNC(=O)c2cc3cc(F)ccc3n2Cc2cccc(c2)C(N)=N)cc1 InChI=1S/C29H28FN5O/c1-4-14-35(2,3)25-11-8-20(9-12-25)18-33-29(36)27-17-23-16-24(30)10-13-26(23)34(27)19-21-6-5-7-22(15-21)28(31)32/h1,5-13,15-17H,14,18-19H2,2-3H3,(H3-,31,32,33,36)/p+1 OHUYGBZNHVTIOY-UHFFFAOYSA-O 13890 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-5-fluoro-1H-indol-2-yl}formamido)methyl]-N,N-dimethyl-N-(prop-2-yn-1-yl)anilinium::3-amidinobenzylindole carboxamide 75 Coagulation factor X Homo sapiens 76 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13890&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11813994 46514268 ZINC13474316 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24913 C[N+](C)(C)c1ccc(CNC(=O)c2cc3ccccc3n2Cc2cccc(c2)C(N)=N)cc1 InChI=1S/C27H29N5O/c1-32(2,3)23-13-11-19(12-14-23)17-30-27(33)25-16-21-8-4-5-10-24(21)31(25)18-20-7-6-9-22(15-20)26(28)29/h4-16H,17-18H2,1-3H3,(H3-,28,29,30,33)/p+1 MFLDBKOULWSBTE-UHFFFAOYSA-O 13891 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-1H-indol-2-yl}formamido)methyl]-N,N,N-trimethylanilinium::3-amidinobenzylindole carboxamide 76 Coagulation factor X Homo sapiens 90 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13891&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 446985 46514269 ZINC13474317 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24914 COc1ccc2cc(C(=O)NCc3ccc(cc3)[N+](C)(C)C)n(Cc3cccc(c3)C(N)=N)c2c1 InChI=1S/C28H31N5O2/c1-33(2,3)23-11-8-19(9-12-23)17-31-28(34)26-15-21-10-13-24(35-4)16-25(21)32(26)18-20-6-5-7-22(14-20)27(29)30/h5-16H,17-18H2,1-4H3,(H3-,29,30,31,34)/p+1 PACCSSQPBHOMFO-UHFFFAOYSA-O 13892 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-6-methoxy-1H-indol-2-yl}formamido)methyl]-N,N,N-trimethylanilinium::3-amidinobenzylindole carboxamide 77 Coagulation factor X Homo sapiens 1760 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13892&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9916347 46514270 ZINC13474318 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26094 COc1ccc(O)c(c1)-c1nc2ccc(cc2[nH]1)C(N)=[NH2+] InChI=1S/C15H14N4O2/c1-21-9-3-5-13(20)10(7-9)15-18-11-4-2-8(14(16)17)6-12(11)19-15/h2-7,20H,1H3,(H3,16,17)(H,18,19)/p+1 ZFCKHJJALHETHG-UHFFFAOYSA-O 13939 2-(2-HYDROXY-5-METHOXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE::APC-6669::{amino[2-(2-hydroxy-5-methoxyphenyl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 8000 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13939&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1GI5,1GI9 5353303 46514313 ZINC13863689 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26095 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1cccc(-c2ccccc2)c1[O-] InChI=1S/C20H16N4O/c21-19(22)13-9-10-16-17(11-13)24-20(23-16)15-8-4-7-14(18(15)25)12-5-2-1-3-6-12/h1-11,25H,(H3,21,22)(H,23,24) LMGQGPVCSYOMNS-UHFFFAOYSA-N 14325 2-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-6-phenylbenzen-1-olate::CRA-7806 Coagulation factor X Homo sapiens 1600 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14325&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O39,1O3A,1O3B,1O3C,1O3D 5353305 46514667 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26096 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1cc(ccc1[O-])[N+]([O-])=O InChI=1S/C14H11N5O3/c15-13(16)7-1-3-10-11(5-7)18-14(17-10)9-6-8(19(21)22)2-4-12(9)20/h1-6,20H,(H3,15,16)(H,17,18) XDLJIVLILSOHRM-UHFFFAOYSA-N 14326 2-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-4-nitrobenzen-1-olate::CRA-8249 Coagulation factor X Homo sapiens 7300 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14326&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11141025 46514668 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26097 NC(=[NH2+])c1ccc2[nH]c(cc2c1)-c1ccccc1[O-] InChI=1S/C15H13N3O/c16-15(17)9-5-6-12-10(7-9)8-13(18-12)11-3-1-2-4-14(11)19/h1-8,18-19H,(H3,16,17) JPGNPKIYCTXJPG-UHFFFAOYSA-N 14327 2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}benzen-1-olate::CRA-8328 Coagulation factor X Homo sapiens 2400 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14327&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1508 46514669 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26098 NC(=[NH2+])c1ccc2[nH]c(cc2c1)-c1cccc(-c2ccccc2)c1[O-] InChI=1S/C21H17N3O/c22-21(23)14-9-10-18-15(11-14)12-19(24-18)17-8-4-7-16(20(17)25)13-5-2-1-3-6-13/h1-12,24-25H,(H3,22,23) GAVRMVQHHVMXFD-UHFFFAOYSA-N 14142 2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phenylbenzen-1-olate::3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-1,1-BIPHENYL-2-OLATE)::APC-8696::CA-04::CRA-8696 Coagulation factor X Homo sapiens 160 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14142&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 696 1O5A,1O3E,1O3G,1O3F,1O2G 447476 46514500 DB03159 ZINC02047576 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26099 Cc1cc(-c2cc3cc(ccc3[nH]2)C(N)=[NH2+])c([O-])c(c1)-c1ccccc1 InChI=1S/C22H19N3O/c1-13-9-17(14-5-3-2-4-6-14)21(26)18(10-13)20-12-16-11-15(22(23)24)7-8-19(16)25-20/h2-12,25-26H,1H3,(H3,23,24) ALBWLRSLXFJFTE-UHFFFAOYSA-N 14329 2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-4-methyl-6-phenylbenzen-1-olate::CRA-9075 Coagulation factor X Homo sapiens 180 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14329&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9949886 46514671 ZINC00025910 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26100 Cc1cc(Br)c([O-])c(c1)-c1cc2cc(ccc2[nH]1)C(N)=[NH2+] InChI=1S/C16H14BrN3O/c1-8-4-11(15(21)12(17)5-8)14-7-10-6-9(16(18)19)2-3-13(10)20-14/h2-7,20-21H,1H3,(H3,18,19) BVTBOJXEAPSOEB-UHFFFAOYSA-N 14330 2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-bromo-4-methylbenzen-1-olate::CRA-9076 Coagulation factor X Homo sapiens 43 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14330&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 907 1O3I,1O3H 447508 46514672 DB04215 ZINC02047575 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26101 Cc1cc(Br)c([O-])c(c1)-c1nc2ccc(cc2[nH]1)C(N)=[NH2+] InChI=1S/C15H13BrN4O/c1-7-4-9(13(21)10(16)5-7)15-19-11-3-2-8(14(17)18)6-12(11)20-15/h2-6,21H,1H3,(H3,17,18)(H,19,20) XKCHOMIJYLHXLI-UHFFFAOYSA-N 14331 2-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-6-bromo-4-methylbenzen-1-olate::CRA-9334 Coagulation factor X Homo sapiens 440 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14331&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O3J,1O3K 10904076 46514673 ZINC13863698 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26102 Cc1cc(Cl)c([O-])c(c1)-c1cc2cc(ccc2[nH]1)C(N)=[NH2+] InChI=1S/C16H14ClN3O/c1-8-4-11(15(21)12(17)5-8)14-7-10-6-9(16(18)19)2-3-13(10)20-14/h2-7,20-21H,1H3,(H3,18,19) DJPZZIPELMVWNS-UHFFFAOYSA-N 14348 2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-chloro-4-methylbenzen-1-olate::CRA-9462 Coagulation factor X Homo sapiens 64 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14348&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646732 46514689 ZINC14955461 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26103 NC(=[NH2+])c1ccc2[nH]c(cc2c1)-c1cc(CC(O)=O)cc(Br)c1[O-] InChI=1S/C17H14BrN3O3/c18-12-4-8(5-15(22)23)3-11(16(12)24)14-7-10-6-9(17(19)20)1-2-13(10)21-14/h1-4,6-7,21,24H,5H2,(H3,19,20)(H,22,23) VIZNZQTZRMTYPZ-UHFFFAOYSA-N 14349 2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-bromo-4-(carboxymethyl)benzen-1-olate::CRA-9678 Coagulation factor X Homo sapiens 43 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14349&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O3L 447512 46514690 ZINC02047573 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26104 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1cc(OC(F)(F)F)ccc1[O-] InChI=1S/C15H11F3N4O2/c16-15(17,18)24-8-2-4-12(23)9(6-8)14-21-10-3-1-7(13(19)20)5-11(10)22-14/h1-6,23H,(H3,19,20)(H,21,22) PJUALJXOBAXGBO-UHFFFAOYSA-N 14357 2-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-4-(trifluoromethoxy)benzen-1-olate::CRA-9785 Coagulation factor X Homo sapiens 11000 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14357&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O3M,1O3N,1O3O 22556917 46514698 ZINC02047572 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26105 NC(=[NH2+])c1cc2cc([nH]c2cc1Cl)-c1cc(Cl)cc(Cl)c1O InChI=1S/C15H10Cl3N3O/c16-7-3-9(14(22)11(18)4-7)13-2-6-1-8(15(19)20)10(17)5-12(6)21-13/h1-5,21-22H,(H3,19,20)/p+1 BWMVXULSVHMQIK-UHFFFAOYSA-O 14151 APC-9850::{amino[6-chloro-2-(3,5-dichloro-2-hydroxyphenyl)-1H-indol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 4700 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14151&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646621 46514509 ZINC14954805 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26106 NC(=[NH2+])c1cc2cc([nH]c2cc1Cl)-c1cccc(-c2ccccc2)c1O InChI=1S/C21H16ClN3O/c22-17-11-18-13(9-16(17)21(23)24)10-19(25-18)15-8-4-7-14(20(15)26)12-5-2-1-3-6-12/h1-11,25-26H,(H3,23,24)/p+1 FEKRWNWZMOSVBX-UHFFFAOYSA-O 14152 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE::APC-10302::CA-14::CRA-10302::{amino[6-chloro-2-(2-hydroxy-3-phenylphenyl)-1H-indol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 24000 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14152&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 132 1O5E,1GJ4,1GJ6,1GJ7 445843 46514510 DB03865 ZINC00603005 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26107 NC(=[NH2+])c1ccc2[nH]c(cc2c1)-c1cccc(OC2CCCC2)c1[O-] InChI=1S/C20H21N3O2/c21-20(22)12-8-9-16-13(10-12)11-17(23-16)15-6-3-7-18(19(15)24)25-14-4-1-2-5-14/h3,6-11,14,23-24H,1-2,4-5H2,(H3,21,22) CFSQPEBVGUSQII-UHFFFAOYSA-N 14332 2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-(cyclopentyloxy)benzen-1-olate::CRA-10433 Coagulation factor X Homo sapiens 1000 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14332&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search CR3 1O2H 447478 46514674 DB03173 ZINC02047594 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26108 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1cccc(OC2CCCC2)c1[O-] InChI=1S/C19H20N4O2/c20-18(21)11-8-9-14-15(10-11)23-19(22-14)13-6-3-7-16(17(13)24)25-12-4-1-2-5-12/h3,6-10,12,24H,1-2,4-5H2,(H3,20,21)(H,22,23) WCFWDBPDMBXMTQ-UHFFFAOYSA-N 14144 2-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-6-(cyclopentyloxy)benzen-1-olate::APC-10655::CA-06 Coagulation factor X Homo sapiens 1400 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14144&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2I,1O3P 6119062 46514502 ZINC05973961 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26109 CC(C)COc1cccc(-c2nc3ccc(cc3[nH]2)C(N)=[NH2+])c1[O-] InChI=1S/C18H20N4O2/c1-10(2)9-24-15-5-3-4-12(16(15)23)18-21-13-7-6-11(17(19)20)8-14(13)22-18/h3-8,10,23H,9H2,1-2H3,(H3,19,20)(H,21,22) HSHVHNIOQTZSOQ-UHFFFAOYSA-N 14145 2-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-6-(2-methylpropoxy)benzen-1-olate::APC-10656::CA-08 Coagulation factor X Homo sapiens 2300 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14145&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2J,1O2K 6119063 46514503 ZINC13444350 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26110 NC(=[NH2+])c1cc2[nH]c(nc2cc1Cl)-c1cccc(-c2ccccc2)c1[O-] InChI=1S/C20H15ClN4O/c21-15-10-17-16(9-14(15)19(22)23)24-20(25-17)13-8-4-7-12(18(13)26)11-5-2-1-3-6-11/h1-10,26H,(H3,22,23)(H,24,25) RPGVMAPDADAHPV-UHFFFAOYSA-N 14153 2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-1,3-benzodiazol-2-yl}-6-phenylbenzen-1-olate::APC-10762 Coagulation factor X Homo sapiens 55000 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14153&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2L,1O2M,1O2N 6102594 46514511 ZINC33360149 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26111 NC(=[NH2+])c1cc2nc([nH]c2cc1F)-c1cccc(-c2ccccc2)c1[O-] InChI=1S/C20H15FN4O/c21-15-10-17-16(9-14(15)19(22)23)24-20(25-17)13-8-4-7-12(18(13)26)11-5-2-1-3-6-11/h1-10,26H,(H3,22,23)(H,24,25) QXRGLPOCPFPVHS-UHFFFAOYSA-N 14333 2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benzodiazol-2-yl}-6-phenylbenzen-1-olate::CA-09::CRA-10818 Coagulation factor X Homo sapiens 12000 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14333&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646619 46514675 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26112 CC(C)COc1cccc(-c2nc3cc(F)c(cc3[nH]2)C(N)=[NH2+])c1[O-] InChI=1S/C18H19FN4O2/c1-9(2)8-25-15-5-3-4-10(16(15)24)18-22-13-6-11(17(20)21)12(19)7-14(13)23-18/h3-7,9,24H,8H2,1-2H3,(H3,20,21)(H,22,23) NSUDDASMRZSVON-UHFFFAOYSA-N 14148 2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benzodiazol-2-yl}-6-(2-methylpropoxy)benzen-1-olate::APC-10950::CA-10 Coagulation factor X Homo sapiens 30000 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14148&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2O 6102526 46514506 ZINC31270922 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26113 NC(=[NH2+])c1cc2cc([nH]c2cc1Cl)-c1cccc(OC2CCCC2)c1[O-] InChI=1S/C20H20ClN3O2/c21-15-10-16-11(8-14(15)20(22)23)9-17(24-16)13-6-3-7-18(19(13)25)26-12-4-1-2-5-12/h3,6-10,12,24-25H,1-2,4-5H2,(H3,22,23) QXAURVOBXQBPAP-UHFFFAOYSA-N 14334 2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-indol-2-yl}-6-(cyclopentyloxy)benzen-1-olate::CRA-10991 Coagulation factor X Homo sapiens 60000 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14334&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 991 1O2Q 447488 46514676 DB01771 ZINC02047589 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26114 C[C@H]1CCCC[C@@H]1Oc1cccc(-c2nc3cc(C(N)=[NH2+])c(F)cc3[nH]2)c1[O-] InChI=1S/C21H23FN4O2/c1-11-5-2-3-7-17(11)28-18-8-4-6-12(19(18)27)21-25-15-9-13(20(23)24)14(22)10-16(15)26-21/h4,6,8-11,17,27H,2-3,5,7H2,1H3,(H3,23,24)(H,25,26)/t11-,17-/m0/s1 CMCDWLMEDRBWIR-GTNSWQLSSA-N 14350 2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benzodiazol-2-yl}-6-{[(1S,2S)-2-methylcyclohexyl]oxy}benzen-1-olate::CA-11::CRA-11092 Coagulation factor X Homo sapiens 32000 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14350&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search CR9 1O5G,1O5F,1O5D,1O5C,1O2R 5326671 46514691 ZINC33359895 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26115 NC(=[NH2+])c1ccc2[nH]c(cc2c1)-c1cc(Cl)cc(-c2ccccc2)c1[O-] InChI=1S/C21H16ClN3O/c22-15-10-16(12-4-2-1-3-5-12)20(26)17(11-15)19-9-14-8-13(21(23)24)6-7-18(14)25-19/h1-11,25-26H,(H3,23,24) QHOGUHKKMFDODA-UHFFFAOYSA-N 14335 2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-4-chloro-6-phenylbenzen-1-olate::CRA-11111 Coagulation factor X Homo sapiens 250 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14335&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11057540 46514677 ZINC13863704 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26116 COc1cc(-c2cc3cc(C(N)=[NH2+])c(Cl)cc3[nH]2)c([O-])c(c1)-c1ccccc1 InChI=1S/C22H18ClN3O2/c1-28-14-9-15(12-5-3-2-4-6-12)21(27)17(10-14)20-8-13-7-16(22(24)25)18(23)11-19(13)26-20/h2-11,26-27H,1H3,(H3,24,25) ITFFOKFQKAACGD-UHFFFAOYSA-N 14351 2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-indol-2-yl}-4-methoxy-6-phenylbenzen-1-olate::CRA-11260 Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14351&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646733 46514692 ZINC14955465 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26117 NC(=[NH2+])c1cc2cc([nH]c2cc1F)-c1cccc(-c2ccccc2)c1O InChI=1S/C21H16FN3O/c22-17-11-18-13(9-16(17)21(23)24)10-19(25-18)15-8-4-7-14(20(15)26)12-5-2-1-3-6-12/h1-11,25-26H,(H3,23,24)/p+1 NKADRYHVDUCFQU-UHFFFAOYSA-O 14150 APC-11417::CA-12::CRA-11417::{amino[6-fluoro-2-(2-hydroxy-3-phenylphenyl)-1H-indol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 980 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14150&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646620 46514508 ZINC00025911 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26118 CN(C)C(=O)c1cc(-c2cc3cc(C(N)=[NH2+])c(Cl)cc3[nH]2)c([O-])c(c1)-c1ccccc1 InChI=1S/C24H21ClN4O2/c1-29(2)24(31)15-9-16(13-6-4-3-5-7-13)22(30)18(10-15)21-11-14-8-17(23(26)27)19(25)12-20(14)28-21/h3-12,28,30H,1-2H3,(H3,26,27) FIKPJJWWHHKTHI-UHFFFAOYSA-N 14352 2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-indol-2-yl}-4-(dimethylcarbamoyl)-6-phenylbenzen-1-olate::CRA-11852 Coagulation factor X Homo sapiens 8000 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14352&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646734 46514693 ZINC14955469 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26119 CN(C)C(=O)c1cc(-c2cc3cc(C(N)=[NH2+])c(F)cc3[nH]2)c([O-])c(c1)-c1ccccc1 InChI=1S/C24H21FN4O2/c1-29(2)24(31)15-9-16(13-6-4-3-5-7-13)22(30)18(10-15)21-11-14-8-17(23(26)27)19(25)12-20(14)28-21/h3-12,28,30H,1-2H3,(H3,26,27) QEWPWXLSDLXYFF-UHFFFAOYSA-N 14353 2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-indol-2-yl}-4-(dimethylcarbamoyl)-6-phenylbenzen-1-olate::CRA-14316 Coagulation factor X Homo sapiens 650 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14353&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646735 46514694 ZINC14955473 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26120 COc1cc(-c2cc3cc(ccc3[nH]2)C(N)=[NH2+])c([O-])c(c1)-c1ccccc1 InChI=1S/C22H19N3O2/c1-27-16-11-17(13-5-3-2-4-6-13)21(26)18(12-16)20-10-15-9-14(22(23)24)7-8-19(15)25-20/h2-12,25-26H,1H3,(H3,23,24) MINVOLKUPZPDNX-UHFFFAOYSA-N 14337 2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-4-methoxy-6-phenylbenzen-1-olate::CRA-14783 Coagulation factor X Homo sapiens 140 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14337&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 783 1O2T 447492 46514678 DB07229 ZINC02047587 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26121 CN(C)C(=O)c1cc(-c2cc3cc(ccc3[nH]2)C(N)=[NH2+])c([O-])c(c1)-c1ccccc1 InChI=1S/C24H22N4O2/c1-28(2)24(30)17-11-18(14-6-4-3-5-7-14)22(29)19(12-17)21-13-16-10-15(23(25)26)8-9-20(16)27-21/h3-13,27,29H,1-2H3,(H3,25,26) XELNXCJTRAIQOD-UHFFFAOYSA-N 14354 2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-4-(dimethylcarbamoyl)-6-phenylbenzen-1-olate::CRA-15441 Coagulation factor X Homo sapiens 52 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14354&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646736 46514695 ZINC14955477 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26122 NC(=[NH2+])c1ccc2[nH]c(cc2c1)-c1cc(cc(-c2ccccc2)c1[O-])[N+]([O-])=O InChI=1S/C21H16N4O3/c22-21(23)13-6-7-18-14(8-13)9-19(24-18)17-11-15(25(27)28)10-16(20(17)26)12-4-2-1-3-5-12/h1-11,24,26H,(H3,22,23) VGQFBYXDHFTAHX-UHFFFAOYSA-N 14338 2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-4-nitro-6-phenylbenzen-1-olate::CRA-15566 Coagulation factor X Homo sapiens 13 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14338&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11057779 46514679 ZINC13863705 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26123 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1cc(cc(Br)c1[O-])[C@@H](CC([O-])=O)C([O-])=O InChI=1S/C18H15BrN4O5/c19-11-4-8(9(18(27)28)6-14(24)25)3-10(15(11)26)17-22-12-2-1-7(16(20)21)5-13(12)23-17/h1-5,9,26H,6H2,(H3,20,21)(H,22,23)(H,24,25)(H,27,28)/p-2/t9-/m1/s1 SJMNJNRKVVVGRB-SECBINFHSA-L 14339 (2R)-2-(3-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-5-bromo-4-oxidophenyl)butanedioate::CRA-16847 Coagulation factor X Homo sapiens 700 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14339&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2U,1O2V,1O2W,1O2X,1O2Y 23646721 46514680 29067 ZINC12501530 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26124 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1cc(cc(-c2ccccc2)c1[O-])[C@@H](CC([O-])=O)C([O-])=O InChI=1S/C24H20N4O5/c25-22(26)13-6-7-18-19(10-13)28-23(27-18)17-9-14(16(24(32)33)11-20(29)30)8-15(21(17)31)12-4-2-1-3-5-12/h1-10,16,31H,11H2,(H3,25,26)(H,27,28)(H,29,30)(H,32,33)/p-2/t16-/m1/s1 FXLFNEVHWHPROF-MRXNPFEDSA-L 14340 (2R)-2-(3-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-4-oxido-5-phenylphenyl)butanedioate::5-amidino benzimidazole analog 1::CRA-16935 Coagulation factor X Homo sapiens 1200 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14340&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646723 46514681 29067 ZINC14955437 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26125 COc1ccccc1-c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=[NH2+])c1[O-])[C@@H](CC([O-])=O)C([O-])=O InChI=1S/C25H22N4O6/c1-35-20-5-3-2-4-14(20)16-8-13(15(25(33)34)11-21(30)31)9-17(22(16)32)24-28-18-7-6-12(23(26)27)10-19(18)29-24/h2-10,15,32H,11H2,1H3,(H3,26,27)(H,28,29)(H,30,31)(H,33,34)/p-2/t15-/m1/s1 HVNXYZZCSQONQC-OAHLLOKOSA-L 14341 (2R)-2-(3-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-5-(2-methoxyphenyl)-4-oxidophenyl)butanedioate::CRA-17312 Coagulation factor X Homo sapiens 3500 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14341&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2Z 17753779 46514682 29067 ZINC14955441 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26126 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1cc(cc(c1[O-])-c1ccccc1F)[C@@H](CC([O-])=O)C([O-])=O InChI=1S/C24H19FN4O5/c25-17-4-2-1-3-13(17)15-7-12(14(24(33)34)10-20(30)31)8-16(21(15)32)23-28-18-6-5-11(22(26)27)9-19(18)29-23/h1-9,14,32H,10H2,(H3,26,27)(H,28,29)(H,30,31)(H,33,34)/p-2/t14-/m1/s1 XCOFROALSAFROV-CQSZACIVSA-L 14342 (2R)-2-(3-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-5-(2-fluorophenyl)-4-oxidophenyl)butanedioate::CRA-17693 Coagulation factor X Homo sapiens 1200 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14342&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O30 17753800 46514683 29067 ZINC12501044 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26127 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1cc(ccc1[O-])[C@@H](CC([O-])=O)C([O-])=O InChI=1S/C18H16N4O5/c19-16(20)9-1-3-12-13(6-9)22-17(21-12)11-5-8(2-4-14(11)23)10(18(26)27)7-15(24)25/h1-6,10,23H,7H2,(H3,19,20)(H,21,22)(H,24,25)(H,26,27)/p-2/t10-/m1/s1 RJQZEHJZWOBYSG-SNVBAGLBSA-L 14343 (2R)-2-(3-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-4-oxidophenyl)butanedioate::CRA-18305 Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14343&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646725 46514684 29067 ZINC14955445 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26128 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1cc(cc(c1[O-])-c1ccccc1[N+]([O-])=O)[C@@H](CC([O-])=O)C([O-])=O InChI=1S/C24H19N5O7/c25-22(26)11-5-6-17-18(9-11)28-23(27-17)16-8-12(14(24(33)34)10-20(30)31)7-15(21(16)32)13-3-1-2-4-19(13)29(35)36/h1-9,14,32H,10H2,(H3,25,26)(H,27,28)(H,30,31)(H,33,34)/p-2/t14-/m1/s1 PFMNUTNXLWAKMB-CQSZACIVSA-L 14344 (2R)-2-(3-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-5-(2-nitrophenyl)-4-oxidophenyl)butanedioate::5-amidino benzimidazole analog 20::CRA-18306 Coagulation factor X Homo sapiens 1200 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14344&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646727 46514685 29067 ZINC14955449 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26129 Cc1ccccc1-c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=[NH2+])c1[O-])[C@@H](CC([O-])=O)C([O-])=O InChI=1S/C25H22N4O5/c1-12-4-2-3-5-15(12)17-8-14(16(25(33)34)11-21(30)31)9-18(22(17)32)24-28-19-7-6-13(23(26)27)10-20(19)29-24/h2-10,16,32H,11H2,1H3,(H3,26,27)(H,28,29)(H,30,31)(H,33,34)/p-2/t16-/m1/s1 LLJXUBIQRITYHZ-MRXNPFEDSA-L 14355 (2R)-2-(3-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-5-(2-methylphenyl)-4-oxidophenyl)butanedioate::CRA-18606 Coagulation factor X Homo sapiens 3100 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14355&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646737 46514696 29067 ZINC14955481 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26130 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1cc(cc(c1[O-])-c1ccccc1N)[C@@H](CC([O-])=O)C([O-])=O InChI=1S/C24H21N5O5/c25-17-4-2-1-3-13(17)15-7-12(14(24(33)34)10-20(30)31)8-16(21(15)32)23-28-18-6-5-11(22(26)27)9-19(18)29-23/h1-9,14,32H,10,25H2,(H3,26,27)(H,28,29)(H,30,31)(H,33,34)/p-2/t14-/m1/s1 KLIWSPNZLMZLEF-CQSZACIVSA-L 14345 (2R)-2-(3-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-5-(2-aminophenyl)-4-oxidophenyl)butanedioate::CRA-18607 Coagulation factor X Homo sapiens 3800 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14345&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O36 23646728 46514686 29067 ZINC14955453 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26131 NC(=[NH2+])c1ccc2[nH]c(cc2c1)-c1cc(cc(Br)c1[O-])[C@@H](CC([O-])=O)C([O-])=O InChI=1S/C19H16BrN3O5/c20-13-5-9(11(19(27)28)7-16(24)25)4-12(17(13)26)15-6-10-3-8(18(21)22)1-2-14(10)23-15/h1-6,11,23,26H,7H2,(H3,21,22)(H,24,25)(H,27,28)/p-2/t11-/m1/s1 OQKMBFOTVQYDAF-LLVKDONJSA-L 14346 (2R)-2-(3-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-5-bromo-4-oxidophenyl)butanedioate::CRA-19858 Coagulation factor X Homo sapiens 48 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14346&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646729 46514687 29067 ZINC14955456 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26132 NC(=[NH2+])c1ccc2[nH]c(cc2c1)-c1cc(cc(c1[O-])-c1ccccc1)[C@@H](CC([O-])=O)C([O-])=O InChI=1S/C25H21N3O5/c26-24(27)14-6-7-20-16(8-14)11-21(28-20)19-10-15(18(25(32)33)12-22(29)30)9-17(23(19)31)13-4-2-1-3-5-13/h1-11,18,28,31H,12H2,(H3,26,27)(H,29,30)(H,32,33)/p-2/t18-/m1/s1 IKPDQBQQJCAKEM-GOSISDBHSA-L 14356 (2R)-2-(3-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-4-oxido-5-phenylphenyl)butanedioate::CRA-20818 Coagulation factor X Homo sapiens 100 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14356&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646739 46514697 29067 ZINC14955485 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26133 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1cc(CC[NH3+])cc(-c2ccccc2)c1[O-] InChI=1S/C22H21N5O/c23-9-8-13-10-16(14-4-2-1-3-5-14)20(28)17(11-13)22-26-18-7-6-15(21(24)25)12-19(18)27-22/h1-7,10-12,28H,8-9,23H2,(H3,24,25)(H,26,27)/p+1 YYUZFCLHOQHMPT-UHFFFAOYSA-O 14358 4-(2-aminiumylethyl)-2-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-6-phenylbenzen-1-olate::CRA-23653 Coagulation factor X Homo sapiens 110 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14358&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O37,1O38 17753797 46514699 58001 ZINC05974761 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26093 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1cc(F)ccc1O InChI=1S/C14H11FN4O/c15-8-2-4-12(20)9(6-8)14-18-10-3-1-7(13(16)17)5-11(10)19-14/h1-6,20H,(H3,16,17)(H,18,19)/p+1 JOGOACSSLJEREC-UHFFFAOYSA-O 14347 CRA-1802::{amino[2-(5-fluoro-2-hydroxyphenyl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 6500 Curated from the literature by BindingDB 10.1016/s0022-2836(03)00399-1 10.7270/Q2R78CGQ 12742021 aid1797196 Katz, BA; Elrod, K; Verner, E; Mackman, RL; Luong, C; Shrader, WD; Sendzik, M; Spencer, JR; Sprengeler, PA; Kolesnikov, A; Tai, VW; Hui, HC; Breitenbucher, JG; Allen, D; Janc, JW Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14347&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O35 23646731 46514688 ZINC02047580 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22536 CC(C)CN(CCC#N)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C24H29ClN4O4S/c1-16(2)15-28(11-4-10-26)23(30)17(3)29-12-9-22(24(29)31)27-34(32,33)21-8-6-18-13-20(25)7-5-19(18)14-21/h5-8,13-14,16-17,22,27H,4,9,11-12,15H2,1-3H3/t17-,22-/m0/s1 AGADDEHLXINQCO-JTSKRJEESA-N 12507 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(2-cyanoethyl)-N-(2-methylpropyl)propanamide::P4 alanylamide pyrrolidin-2-one 18 Coagulation factor X Homo sapiens 136 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12507&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646112 46512966 ZINC14949952 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22537 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCC#N)C1CC1 InChI=1S/C23H25ClN4O4S/c1-15(22(29)28(11-2-10-25)19-6-7-19)27-12-9-21(23(27)30)26-33(31,32)20-8-4-16-13-18(24)5-3-17(16)14-20/h3-5,8,13-15,19,21,26H,2,6-7,9,11-12H2,1H3/t15-,21-/m0/s1 CELJRFQNXPEIDE-BTYIYWSLSA-N 12508 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(2-cyanoethyl)-N-cyclopropylpropanamide::P4 alanylamide pyrrolidin-2-one 19 Coagulation factor X Homo sapiens 57 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12508&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646113 46512967 ZINC14949955 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22538 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCC#N)CC1CC1 InChI=1S/C24H27ClN4O4S/c1-16(23(30)28(11-2-10-26)15-17-3-4-17)29-12-9-22(24(29)31)27-34(32,33)21-8-6-18-13-20(25)7-5-19(18)14-21/h5-8,13-14,16-17,22,27H,2-4,9,11-12,15H2,1H3/t16-,22-/m0/s1 NUUHVHOGYJZNGY-AOMKIAJQSA-N 12509 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(2-cyanoethyl)-N-(cyclopropylmethyl)propanamide::P4 alanylamide pyrrolidin-2-one 20 Coagulation factor X Homo sapiens 3 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12509&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10174488 46512968 ZINC14949960 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22539 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCC#N)C1CCC1 InChI=1S/C24H27ClN4O4S/c1-16(23(30)29(12-3-11-26)20-4-2-5-20)28-13-10-22(24(28)31)27-34(32,33)21-9-7-17-14-19(25)8-6-18(17)15-21/h6-9,14-16,20,22,27H,2-5,10,12-13H2,1H3/t16-,22-/m0/s1 PNZATZXFJZLWFP-AOMKIAJQSA-N 12510 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(2-cyanoethyl)-N-cyclobutylpropanamide::P4 alanylamide pyrrolidin-2-one 21 Coagulation factor X Homo sapiens 15 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12510&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10174487 46512969 ZINC14949964 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22540 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCC#N)C1CCCC1 InChI=1S/C25H29ClN4O4S/c1-17(24(31)30(13-4-12-27)21-5-2-3-6-21)29-14-11-23(25(29)32)28-35(33,34)22-10-8-18-15-20(26)9-7-19(18)16-22/h7-10,15-17,21,23,28H,2-6,11,13-14H2,1H3/t17-,23-/m0/s1 ORVNIRLLDIQNIF-SBUREZEXSA-N 12511 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(2-cyanoethyl)-N-cyclopentylpropanamide::P4 alanylamide pyrrolidin-2-one 22 Coagulation factor X Homo sapiens 11 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12511&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10311517 46512970 ZINC14949968 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22541 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCC#N)C1CCCCC1 InChI=1S/C26H31ClN4O4S/c1-18(25(32)31(14-5-13-28)22-6-3-2-4-7-22)30-15-12-24(26(30)33)29-36(34,35)23-11-9-19-16-21(27)10-8-20(19)17-23/h8-11,16-18,22,24,29H,2-7,12,14-15H2,1H3/t18-,24-/m0/s1 RMFIYMPMMQYQQE-UUOWRZLLSA-N 12512 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(2-cyanoethyl)-N-cyclohexylpropanamide::P4 alanylamide pyrrolidin-2-one 23 Coagulation factor X Homo sapiens 73 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12512&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646114 46512971 ZINC14949971 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22542 CCN(Cc1ccncc1)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C25H27ClN4O4S/c1-3-29(16-18-8-11-27-12-9-18)24(31)17(2)30-13-10-23(25(30)32)28-35(33,34)22-7-5-19-14-21(26)6-4-20(19)15-22/h4-9,11-12,14-15,17,23,28H,3,10,13,16H2,1-2H3/t17-,23-/m0/s1 XHNRETTXQLOZNQ-SBUREZEXSA-N 12513 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-ethyl-N-(pyridin-4-ylmethyl)propanamide::P4 alanylamide pyrrolidin-2-one 24 Coagulation factor X Homo sapiens 27 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12513&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646115 46512972 ZINC14949974 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22543 CC(C)N(Cc1ccccc1)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C27H30ClN3O4S/c1-18(2)31(17-20-7-5-4-6-8-20)26(32)19(3)30-14-13-25(27(30)33)29-36(34,35)24-12-10-21-15-23(28)11-9-22(21)16-24/h4-12,15-16,18-19,25,29H,13-14,17H2,1-3H3/t19-,25-/m0/s1 ADSCKFYPYWFTKB-DFBJGRDBSA-N 12514 (2S)-N-benzyl-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 25 Coagulation factor X Homo sapiens 24 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12514&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646116 46512973 ZINC14949978 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22544 CC(C)N(Cc1ccccn1)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C26H29ClN4O4S/c1-17(2)31(16-22-6-4-5-12-28-22)25(32)18(3)30-13-11-24(26(30)33)29-36(34,35)23-10-8-19-14-21(27)9-7-20(19)15-23/h4-10,12,14-15,17-18,24,29H,11,13,16H2,1-3H3/t18-,24-/m0/s1 QVQZHWGMGSPGNN-UUOWRZLLSA-N 12515 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)-N-(pyridin-2-ylmethyl)propanamide::P4 alanylamide pyrrolidin-2-one 26 Coagulation factor X Homo sapiens 11 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12515&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10152710 46512974 ZINC14949981 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22545 CC(C)N(Cc1cccnc1)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C26H29ClN4O4S/c1-17(2)31(16-19-5-4-11-28-15-19)25(32)18(3)30-12-10-24(26(30)33)29-36(34,35)23-9-7-20-13-22(27)8-6-21(20)14-23/h4-9,11,13-15,17-18,24,29H,10,12,16H2,1-3H3/t18-,24-/m0/s1 QQLOMOCVBWOICY-UUOWRZLLSA-N 12516 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)-N-(pyridin-3-ylmethyl)propanamide::P4 alanylamide pyrrolidin-2-one 27 Coagulation factor X Homo sapiens 9 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12516&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10311669 46512975 ZINC14949984 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22546 CC(C)N(Cc1ccncc1)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C26H29ClN4O4S/c1-17(2)31(16-19-8-11-28-12-9-19)25(32)18(3)30-13-10-24(26(30)33)29-36(34,35)23-7-5-20-14-22(27)6-4-21(20)15-23/h4-9,11-12,14-15,17-18,24,29H,10,13,16H2,1-3H3/t18-,24-/m0/s1 WDWBAVTWZNDXDI-UUOWRZLLSA-N 12517 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)-N-(pyridin-4-ylmethyl)propanamide::P4 alanylamide pyrrolidin-2-one 28 Coagulation factor X Homo sapiens 6 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12517&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10218126 46512976 ZINC14949989 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22547 CC(C)N(CCc1ccccn1)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C27H31ClN4O4S/c1-18(2)31(14-11-23-6-4-5-13-29-23)26(33)19(3)32-15-12-25(27(32)34)30-37(35,36)24-10-8-20-16-22(28)9-7-21(20)17-24/h4-10,13,16-19,25,30H,11-12,14-15H2,1-3H3/t19-,25-/m0/s1 DMXBLIZKSSZALH-DFBJGRDBSA-N 12518 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)-N-[2-(pyridin-2-yl)ethyl]propanamide::P4 alanylamide pyrrolidin-2-one 29 Coagulation factor X Homo sapiens 13 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12518&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10289601 46512977 ZINC14949993 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22548 CC(C)N(CCO)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C22H28ClN3O5S/c1-14(2)25(10-11-27)21(28)15(3)26-9-8-20(22(26)29)24-32(30,31)19-7-5-16-12-18(23)6-4-17(16)13-19/h4-7,12-15,20,24,27H,8-11H2,1-3H3/t15-,20-/m0/s1 RIQHMAOZARRSCE-YWZLYKJASA-N 12519 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(2-hydroxyethyl)-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 30 Coagulation factor X Homo sapiens 6 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12519&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10311026 46512978 ZINC14949996 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22549 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCO)CC1CC1 InChI=1S/C23H28ClN3O5S/c1-15(22(29)26(10-11-28)14-16-2-3-16)27-9-8-21(23(27)30)25-33(31,32)20-7-5-17-12-19(24)6-4-18(17)13-20/h4-7,12-13,15-16,21,25,28H,2-3,8-11,14H2,1H3/t15-,21-/m0/s1 YFXPVYZSRZAHLN-BTYIYWSLSA-N 12520 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(cyclopropylmethyl)-N-(2-hydroxyethyl)propanamide::P4 alanylamide pyrrolidin-2-one 31 Coagulation factor X Homo sapiens 7 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12520&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10195824 46512979 ZINC14949999 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22550 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)NCCN InChI=1S/C19H23ClN4O4S/c1-12(18(25)22-8-7-21)24-9-6-17(19(24)26)23-29(27,28)16-5-3-13-10-15(20)4-2-14(13)11-16/h2-5,10-12,17,23H,6-9,21H2,1H3,(H,22,25)/t12-,17-/m0/s1 IHOBTRMGUNYZFX-SJCJKPOMSA-N 12521 (2S)-N-(2-aminoethyl)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]propanamide::P4 alanylamide pyrrolidin-2-one 32 Coagulation factor X Homo sapiens 4100 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12521&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646117 46512980 ZINC14950004 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22551 CC(C)N(CCN)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C22H29ClN4O4S/c1-14(2)26(11-9-24)21(28)15(3)27-10-8-20(22(27)29)25-32(30,31)19-7-5-16-12-18(23)6-4-17(16)13-19/h4-7,12-15,20,25H,8-11,24H2,1-3H3/t15-,20-/m0/s1 FBHQNSBRZXDZSA-YWZLYKJASA-N 12522 (2S)-N-(2-aminoethyl)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 33 Coagulation factor X Homo sapiens 4 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12522&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10311006 46512981 ZINC14950007 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22552 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCN)CC1CC1 InChI=1S/C23H29ClN4O4S/c1-15(22(29)27(11-9-25)14-16-2-3-16)28-10-8-21(23(28)30)26-33(31,32)20-7-5-17-12-19(24)6-4-18(17)13-20/h4-7,12-13,15-16,21,26H,2-3,8-11,14,25H2,1H3/t15-,21-/m0/s1 CJKICYYTZSOGRG-BTYIYWSLSA-N 12523 (2S)-N-(2-aminoethyl)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(cyclopropylmethyl)propanamide::P4 alanylamide pyrrolidin-2-one 34 Coagulation factor X Homo sapiens 15 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12523&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646118 46512982 ZINC14950010 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22553 CC(C)N(CCC(N)=O)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C23H29ClN4O5S/c1-14(2)27(11-9-21(25)29)22(30)15(3)28-10-8-20(23(28)31)26-34(32,33)19-7-5-16-12-18(24)6-4-17(16)13-19/h4-7,12-15,20,26H,8-11H2,1-3H3,(H2,25,29)/t15-,20-/m0/s1 WKOFLENOFRAAGC-YWZLYKJASA-N 12524 (2S)-N-(2-carbamoylethyl)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 35 Coagulation factor X Homo sapiens 11 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12524&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646119 46512983 ZINC14950014 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22554 CC(C)N(CCNC(N)=O)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C23H30ClN5O5S/c1-14(2)28(11-9-26-23(25)32)21(30)15(3)29-10-8-20(22(29)31)27-35(33,34)19-7-5-16-12-18(24)6-4-17(16)13-19/h4-7,12-15,20,27H,8-11H2,1-3H3,(H3,25,26,32)/t15-,20-/m0/s1 FKIUZSOTEOEQSR-YWZLYKJASA-N 12525 (2S)-N-[2-(carbamoylamino)ethyl]-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 36 Coagulation factor X Homo sapiens 2 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12525&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10128598 46512984 ZINC14950018 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22555 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCNC(N)=O)CC1CC1 InChI=1S/C24H30ClN5O5S/c1-15(22(31)29(14-16-2-3-16)11-9-27-24(26)33)30-10-8-21(23(30)32)28-36(34,35)20-7-5-17-12-19(25)6-4-18(17)13-20/h4-7,12-13,15-16,21,28H,2-3,8-11,14H2,1H3,(H3,26,27,33)/t15-,21-/m0/s1 ZFNTXNMCVJKZCU-BTYIYWSLSA-N 12526 (2S)-N-[2-(carbamoylamino)ethyl]-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(cyclopropylmethyl)propanamide::P4 alanylamide pyrrolidin-2-one 37 Coagulation factor X Homo sapiens 7 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12526&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10152785 46512985 ZINC14950021 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22556 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)NCCNS(C)(=O)=O InChI=1S/C20H25ClN4O6S2/c1-13(19(26)22-8-9-23-32(2,28)29)25-10-7-18(20(25)27)24-33(30,31)17-6-4-14-11-16(21)5-3-15(14)12-17/h3-6,11-13,18,23-24H,7-10H2,1-2H3,(H,22,26)/t13-,18-/m0/s1 JYHVNPKHZGTZQK-UGSOOPFHSA-N 12527 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(2-methanesulfonamidoethyl)propanamide::P4 alanylamide pyrrolidin-2-one 38 Coagulation factor X Homo sapiens 39000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12527&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646120 46512986 ZINC14950025 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22557 CC(C)N(CCNS(C)(=O)=O)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C23H31ClN4O6S2/c1-15(2)27(12-10-25-35(4,31)32)22(29)16(3)28-11-9-21(23(28)30)26-36(33,34)20-8-6-17-13-19(24)7-5-18(17)14-20/h5-8,13-16,21,25-26H,9-12H2,1-4H3/t16-,21-/m0/s1 MTIPCPPIOZUMIV-KKSFZXQISA-N 12528 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(2-methanesulfonamidoethyl)-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 39 Coagulation factor X Homo sapiens 1 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12528&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GSJ 2J4I 9549260 46512987 ZINC14950028 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22558 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N(CCNS(C)(=O)=O)CC1CC1 InChI=1S/C24H31ClN4O6S2/c1-16(23(30)28(15-17-3-4-17)12-10-26-36(2,32)33)29-11-9-22(24(29)31)27-37(34,35)21-8-6-18-13-20(25)7-5-19(18)14-21/h5-8,13-14,16-17,22,26-27H,3-4,9-12,15H2,1-2H3/t16-,22-/m0/s1 WKFVNJACXOSZIA-AOMKIAJQSA-N 12529 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(cyclopropylmethyl)-N-(2-methanesulfonamidoethyl)propanamide::P4 alanylamide pyrrolidin-2-one 40 Coagulation factor X Homo sapiens 2 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12529&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10129004 46512988 ZINC14950031 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22559 CC(C)N(CCS(N)(=O)=O)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C22H29ClN4O6S2/c1-14(2)26(10-11-34(24,30)31)21(28)15(3)27-9-8-20(22(27)29)25-35(32,33)19-7-5-16-12-18(23)6-4-17(16)13-19/h4-7,12-15,20,25H,8-11H2,1-3H3,(H2,24,30,31)/t15-,20-/m0/s1 LEXGOWJJRLAVCQ-YWZLYKJASA-N 12530 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)-N-(2-sulfamoylethyl)propanamide::P4 alanylamide pyrrolidin-2-one 41 Coagulation factor X Homo sapiens 3 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12530&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646121 46512989 ZINC14950034 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22560 CC(C)N(CCN(C)C)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C24H33ClN4O4S/c1-16(2)28(13-12-27(4)5)23(30)17(3)29-11-10-22(24(29)31)26-34(32,33)21-9-7-18-14-20(25)8-6-19(18)15-21/h6-9,14-17,22,26H,10-13H2,1-5H3/t17-,22-/m0/s1 HYHOSSUACIGAJZ-JTSKRJEESA-N 12531 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-[2-(dimethylamino)ethyl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 42 Coagulation factor X Homo sapiens 2 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12531&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10152434 46512990 ZINC14950037 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22561 CC(C)N(CCN1CCCCC1)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C27H37ClN4O4S/c1-19(2)31(16-15-30-12-5-4-6-13-30)26(33)20(3)32-14-11-25(27(32)34)29-37(35,36)24-10-8-21-17-23(28)9-7-22(21)18-24/h7-10,17-20,25,29H,4-6,11-16H2,1-3H3/t20-,25-/m0/s1 XDQOHEUNOFFJAQ-CPJSRVTESA-N 12532 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-[2-(piperidin-1-yl)ethyl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 43 Coagulation factor X Homo sapiens 2 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12532&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10174991 46512991 ZINC14950041 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22562 CC(C)N(CCN1CCOCC1)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C26H35ClN4O5S/c1-18(2)30(11-10-29-12-14-36-15-13-29)25(32)19(3)31-9-8-24(26(31)33)28-37(34,35)23-7-5-20-16-22(27)6-4-21(20)17-23/h4-7,16-19,24,28H,8-15H2,1-3H3/t19-,24-/m0/s1 SCSMSHQTWYIIRL-CYFREDJKSA-N 12533 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-[2-(morpholin-4-yl)ethyl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 44 Coagulation factor X Homo sapiens 4 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12533&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10239728 46512992 ZINC14950044 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22563 CC(C)N(CCN1C=CC=CC=C1)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C28H33ClN4O4S/c1-20(2)32(17-16-31-13-6-4-5-7-14-31)27(34)21(3)33-15-12-26(28(33)35)30-38(36,37)25-11-9-22-18-24(29)10-8-23(22)19-25/h4-11,13-14,18-21,26,30H,12,15-17H2,1-3H3/t21-,26-/m0/s1 IWGAIPIVZUEJCP-LVXARBLLSA-N 12534 (2S)-N-[2-(1H-azepin-1-yl)ethyl]-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 45 Coagulation factor X Homo sapiens 2 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12534&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646122 46512993 ZINC14950047 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22564 CC(C)N(CCCN)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C23H31ClN4O4S/c1-15(2)27(11-4-10-25)22(29)16(3)28-12-9-21(23(28)30)26-33(31,32)20-8-6-17-13-19(24)7-5-18(17)14-20/h5-8,13-16,21,26H,4,9-12,25H2,1-3H3/t16-,21-/m0/s1 CFYBGTVIIKYBIO-KKSFZXQISA-N 12535 (2S)-N-(3-aminopropyl)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 46 Coagulation factor X Homo sapiens 2 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12535&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10195843 46512994 ZINC14950051 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22565 CC(C)N(CCCNC(N)=O)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C24H32ClN5O5S/c1-15(2)29(11-4-10-27-24(26)33)22(31)16(3)30-12-9-21(23(30)32)28-36(34,35)20-8-6-17-13-19(25)7-5-18(17)14-20/h5-8,13-16,21,28H,4,9-12H2,1-3H3,(H3,26,27,33)/t16-,21-/m0/s1 LPFRYZFMDLZOOO-KKSFZXQISA-N 12536 (2S)-N-[3-(carbamoylamino)propyl]-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 47 Coagulation factor X Homo sapiens 5 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12536&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10311761 46512995 ZINC14950054 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22566 CC(C)N(CCCNS(C)(=O)=O)C(=O)[C@H](C)N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C24H33ClN4O6S2/c1-16(2)28(12-5-11-26-36(4,32)33)23(30)17(3)29-13-10-22(24(29)31)27-37(34,35)21-9-7-18-14-20(25)8-6-19(18)15-21/h6-9,14-17,22,26-27H,5,10-13H2,1-4H3/t17-,22-/m0/s1 CKXPFCDYOFXCRL-JTSKRJEESA-N 12537 (2S)-2-[(3S)-3-[(6-chloronaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]-N-(3-methanesulfonamidopropyl)-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 48 Coagulation factor X Homo sapiens 3 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12537&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10175171 46512996 ZINC14950057 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22567 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H24ClN3O5S/c1-14(20(26)24-8-10-30-11-9-24)25-7-6-19(21(25)27)23-31(28,29)18-5-3-15-12-17(22)4-2-16(15)13-18/h2-5,12-14,19,23H,6-11H2,1H3/t14-,19-/m0/s1 ICLOZQFWTRAYPX-LIRRHRJNSA-N 12538 6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1a::aminopyrrolidin-2-one 1::pyrrolidin-2-one-based inhibitor 24 Coagulation factor X Homo sapiens 6 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12538&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GSK 2CJI 6852168 46512997 DB07847 ZINC14950061 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22568 CC(C)N(CCO)C(=O)[C@H](C)N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C24H31ClN4O6S/c1-15(2)27(10-11-30)23(32)16(3)28-9-8-21(24(28)33)29(14-22(26)31)36(34,35)20-7-5-17-12-19(25)6-4-18(17)13-20/h4-7,12-13,15-16,21,30H,8-11,14H2,1-3H3,(H2,26,31)/t16-,21-/m0/s1 AQIQXBFMTBVKLX-KKSFZXQISA-N 12539 (2S)-2-[(3S)-3-{2-[(6-chloronaphthalene-2-)sulfonamido]acetamide}-2-oxopyrrolidin-1-yl]-N-(2-hydroxyethyl)-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 49 Coagulation factor X Homo sapiens 1 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12539&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10152813 46512998 ZINC14950064 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22569 CC(C)N(CCN)C(=O)[C@H](C)N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C24H32ClN5O5S/c1-15(2)28(11-9-26)23(32)16(3)29-10-8-21(24(29)33)30(14-22(27)31)36(34,35)20-7-5-17-12-19(25)6-4-18(17)13-20/h4-7,12-13,15-16,21H,8-11,14,26H2,1-3H3,(H2,27,31)/t16-,21-/m0/s1 BANMLSXRXUYSKE-KKSFZXQISA-N 12540 (2S)-N-(2-aminoethyl)-2-[(3S)-3-{2-[(6-chloronaphthalene-2-)sulfonamido]acetamide}-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 50 Coagulation factor X Homo sapiens <1 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12540&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10311760 46512999 ZINC14950067 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22570 CC(C)N(CCNC(N)=O)C(=O)[C@H](C)N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C25H33ClN6O6S/c1-15(2)30(11-9-29-25(28)36)23(34)16(3)31-10-8-21(24(31)35)32(14-22(27)33)39(37,38)20-7-5-17-12-19(26)6-4-18(17)13-20/h4-7,12-13,15-16,21H,8-11,14H2,1-3H3,(H2,27,33)(H3,28,29,36)/t16-,21-/m0/s1 BRRGSGRWNJJGEB-KKSFZXQISA-N 12541 (2S)-N-[2-(carbamoylamino)ethyl]-2-[(3S)-3-{2-[(6-chloronaphthalene-2-)sulfonamido]acetamide}-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 51 Coagulation factor X Homo sapiens 1 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12541&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10196732 46513000 ZINC14950070 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22571 CC(C)N(CCNS(C)(=O)=O)C(=O)[C@H](C)N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C25H34ClN5O7S2/c1-16(2)29(12-10-28-39(4,35)36)24(33)17(3)30-11-9-22(25(30)34)31(15-23(27)32)40(37,38)21-8-6-18-13-20(26)7-5-19(18)14-21/h5-8,13-14,16-17,22,28H,9-12,15H2,1-4H3,(H2,27,32)/t17-,22-/m0/s1 AAIIKBIMTIKSKH-JTSKRJEESA-N 12542 (2S)-2-[(3S)-3-{2-[(6-chloronaphthalene-2-)sulfonamido]acetamide}-2-oxopyrrolidin-1-yl]-N-(2-methanesulfonamidoethyl)-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 52 Coagulation factor X Homo sapiens <1 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12542&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646123 46513001 ZINC14950073 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22572 CC(C)N(CCN1CCCCC1)C(=O)[C@H](C)N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C29H40ClN5O5S/c1-20(2)33(16-15-32-12-5-4-6-13-32)28(37)21(3)34-14-11-26(29(34)38)35(19-27(31)36)41(39,40)25-10-8-22-17-24(30)9-7-23(22)18-25/h7-10,17-18,20-21,26H,4-6,11-16,19H2,1-3H3,(H2,31,36)/t21-,26-/m0/s1 SBQDLUVJUKCCRM-LVXARBLLSA-N 12543 (2S)-2-[(3S)-3-{2-[(6-chloronaphthalene-2-)sulfonamido]acetamide}-2-oxopyrrolidin-1-yl]-N-[2-(piperidin-1-yl)ethyl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 53 Coagulation factor X Homo sapiens 1 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12543&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646124 46513002 ZINC14950076 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22573 CC(C)N(CCN1CCOCC1)C(=O)[C@H](C)N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C28H38ClN5O6S/c1-19(2)32(11-10-31-12-14-40-15-13-31)27(36)20(3)33-9-8-25(28(33)37)34(18-26(30)35)41(38,39)24-7-5-21-16-23(29)6-4-22(21)17-24/h4-7,16-17,19-20,25H,8-15,18H2,1-3H3,(H2,30,35)/t20-,25-/m0/s1 MHADKNWFCIXJMD-CPJSRVTESA-N 12544 (2S)-2-[(3S)-3-{2-[(6-chloronaphthalene-2-)sulfonamido]acetamide}-2-oxopyrrolidin-1-yl]-N-[2-(morpholin-4-yl)ethyl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 54 Coagulation factor X Homo sapiens 1 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12544&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646125 46513003 ZINC14950080 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22574 CC(C)N(CCN1C=CC=CC=C1)C(=O)[C@H](C)N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O InChI=1S/C30H36ClN5O5S/c1-21(2)34(17-16-33-13-6-4-5-7-14-33)29(38)22(3)35-15-12-27(30(35)39)36(20-28(32)37)42(40,41)26-11-9-23-18-25(31)10-8-24(23)19-26/h4-11,13-14,18-19,21-22,27H,12,15-17,20H2,1-3H3,(H2,32,37)/t22-,27-/m0/s1 BJVRRVDOTUAUGN-CUNXSJBXSA-N 12545 (2S)-N-[2-(1H-azepin-1-yl)ethyl]-2-[(3S)-3-{2-[(6-chloronaphthalene-2-)sulfonamido]acetamide}-2-oxopyrrolidin-1-yl]-N-(propan-2-yl)propanamide::P4 alanylamide pyrrolidin-2-one 55 Coagulation factor X Homo sapiens <1 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.001 10.7270/Q2CF9NB8 16982190 aid1796912 Young, RJ; Campbell, M; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Chan, C; Convery, MA; Crowe, MC; Dayal, S; Diallo, H; Kelly, HA; King, NP; Kleanthous, S; Mason, AM; Mordaunt, JE; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Smith, PW; Watson, NS; Weston, HE; Zhou, P GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12545&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646126 46513004 ZINC14950084 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22575 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3cc(Cl)ccc3s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H22ClN3O5S2/c1-12(18(24)22-6-8-28-9-7-22)23-5-4-15(19(23)25)21-30(26,27)17-11-13-10-14(20)2-3-16(13)29-17/h2-3,10-12,15,21H,4-9H2,1H3/t12-,15-/m0/s1 LTJNKFUIOOJXNJ-WFASDCNBSA-N 12546 5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide::Arylsulfonamide 1b::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1d Coagulation factor X Homo sapiens 47 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.092 10.7270/Q27S7M0T 16982192 aid1796915 Senger, S; Convery, MA; Chan, C; Watson, NS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12546&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GS5 2J38 9549259 46513005 DB07843 ZINC14950088 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22576 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3ccc(Cl)cc3s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H22ClN3O5S2/c1-12(18(24)22-6-8-28-9-7-22)23-5-4-15(19(23)25)21-30(26,27)17-10-13-2-3-14(20)11-16(13)29-17/h2-3,10-12,15,21H,4-9H2,1H3/t12-,15-/m0/s1 PHLKBODTBJLXRD-WFASDCNBSA-N 12547 6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide::Arylsulfonamide 1a::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1e Coagulation factor X Homo sapiens 15 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.092 10.7270/Q27S7M0T 16982192 aid1796915 Senger, S; Convery, MA; Chan, C; Watson, NS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12547&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GS6 2J34 9549258 46513006 DB07844 ZINC14950092 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22577 C[C@H](N1CC[C@H](NS(=O)(=O)c2nc3cc(Cl)ccc3s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C18H21ClN4O5S2/c1-11(16(24)22-6-8-28-9-7-22)23-5-4-13(17(23)25)21-30(26,27)18-20-14-10-12(19)2-3-15(14)29-18/h2-3,10-11,13,21H,4-9H2,1H3/t11-,13-/m0/s1 SRLCBDHMFDIPRY-AAEUAGOBSA-N 12548 5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1,3-benzothiazole-2-sulfonamide::Arylsulfonamide 2b::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1r Coagulation factor X Homo sapiens 112 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.092 10.7270/Q27S7M0T 16982192 aid1796915 Senger, S; Convery, MA; Chan, C; Watson, NS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12548&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16124762 46513007 ZINC14950097 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22578 C[C@H](N1CC[C@H](NS(=O)(=O)c2nc3ccc(Cl)cc3s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C18H21ClN4O5S2/c1-11(16(24)22-6-8-28-9-7-22)23-5-4-14(17(23)25)21-30(26,27)18-20-13-3-2-12(19)10-15(13)29-18/h2-3,10-11,14,21H,4-9H2,1H3/t11-,14-/m0/s1 KOOMWRKYGHYHOT-FZMZJTMJSA-N 12549 6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1,3-benzothiazole-2-sulfonamide::Arylsulfonamide 2a::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1q Coagulation factor X Homo sapiens 4161 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.092 10.7270/Q27S7M0T 16982192 aid1796915 Senger, S; Convery, MA; Chan, C; Watson, NS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12549&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16124761 46513008 ZINC14950100 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22579 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3cc(Cl)ccc3[nH]2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H23ClN4O5S/c1-12(18(25)23-6-8-29-9-7-23)24-5-4-16(19(24)26)22-30(27,28)17-11-13-10-14(20)2-3-15(13)21-17/h2-3,10-12,16,21-22H,4-9H2,1H3/t12-,16-/m0/s1 BHNMMFGOJRIAEZ-LRDDRELGSA-N 12550 5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1H-indole-2-sulfonamide::Arylsulfonamide 3b::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1s Coagulation factor X Homo sapiens 90 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.092 10.7270/Q27S7M0T 16982192 aid1796915 Senger, S; Convery, MA; Chan, C; Watson, NS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12550&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GSQ 2J2U 9549257 46513009 DB07848 ZINC14950104 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22580 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3ccc(Cl)cc3[nH]2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H23ClN4O5S/c1-12(18(25)23-6-8-29-9-7-23)24-5-4-15(19(24)26)22-30(27,28)17-10-13-2-3-14(20)11-16(13)21-17/h2-3,10-12,15,21-22H,4-9H2,1H3/t12-,15-/m0/s1 YMUHEQCMXFHGRO-WFASDCNBSA-N 12551 6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1H-indole-2-sulfonamide::Arylsulfonamide 3a::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1t Coagulation factor X Homo sapiens 170 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.092 10.7270/Q27S7M0T 16982192 aid1796915 Senger, S; Convery, MA; Chan, C; Watson, NS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12551&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16124763 46513010 ZINC14950107 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22581 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3cc(Cl)ccc3o2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H22ClN3O6S/c1-12(18(24)22-6-8-28-9-7-22)23-5-4-15(19(23)25)21-30(26,27)17-11-13-10-14(20)2-3-16(13)29-17/h2-3,10-12,15,21H,4-9H2,1H3/t12-,15-/m0/s1 LHWFJBCPONIVNC-WFASDCNBSA-N 12552 5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1-benzofuran-2-sulfonamide::Arylsulfonamide 4b::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1p Coagulation factor X Homo sapiens 782 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.092 10.7270/Q27S7M0T 16982192 aid1796915 Senger, S; Convery, MA; Chan, C; Watson, NS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12552&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16125616 46513011 ZINC14950110 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22582 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3ccc(Cl)cc3o2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H22ClN3O6S/c1-12(18(24)22-6-8-28-9-7-22)23-5-4-15(19(23)25)21-30(26,27)17-10-13-2-3-14(20)11-16(13)29-17/h2-3,10-12,15,21H,4-9H2,1H3/t12-,15-/m0/s1 XNSIFTKEVAXGSM-WFASDCNBSA-N 12553 6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1-benzofuran-2-sulfonamide::Arylsulfonamide 4a::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1o Coagulation factor X Homo sapiens 285 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.092 10.7270/Q27S7M0T 16982192 aid1796915 Senger, S; Convery, MA; Chan, C; Watson, NS GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12553&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16124704 46513012 ZINC14950113 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22583 CN([C@H]1CCN(CC(=O)N2CCCCCC2)C1=O)S(=O)(=O)c1ccc2cc(Cl)ccc2c1 InChI=1S/C23H28ClN3O4S/c1-25(32(30,31)20-9-7-17-14-19(24)8-6-18(17)15-20)21-10-13-27(23(21)29)16-22(28)26-11-4-2-3-5-12-26/h6-9,14-15,21H,2-5,10-13,16H2,1H3/t21-/m0/s1 MHJMRMTUDWQOGT-NRFANRHFSA-N 12554 N-[(3S)-1-[2-(azepan-1-yl)-2-oxoethyl]-2-oxopyrrolidin-3-yl]-6-chloro-N-methylnaphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 2 Coagulation factor X Homo sapiens 60 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12554&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646127 46513013 ZINC14950116 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22584 CN([C@H]1CCN(CC(=O)N2CCCCC2)C1=O)S(=O)(=O)c1ccc2cc(Cl)ccc2c1 InChI=1S/C22H26ClN3O4S/c1-24(31(29,30)19-8-6-16-13-18(23)7-5-17(16)14-19)20-9-12-26(22(20)28)15-21(27)25-10-3-2-4-11-25/h5-8,13-14,20H,2-4,9-12,15H2,1H3/t20-/m0/s1 MWQBNLSJBXNUDC-FQEVSTJZSA-N 12555 6-chloro-N-methyl-N-[(3S)-2-oxo-1-[2-oxo-2-(piperidin-1-yl)ethyl]pyrrolidin-3-yl]naphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 3 Coagulation factor X Homo sapiens 72 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12555&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646128 46513014 ZINC14950120 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22585 Clc1ccc2cc(ccc2c1)S(=O)(=O)N[C@H]1CCN(CC(=O)N2CCCCC2)C1=O InChI=1S/C21H24ClN3O4S/c22-17-6-4-16-13-18(7-5-15(16)12-17)30(28,29)23-19-8-11-25(21(19)27)14-20(26)24-9-2-1-3-10-24/h4-7,12-13,19,23H,1-3,8-11,14H2/t19-/m0/s1 JGFOOSCAWPOWNG-IBGZPJMESA-N 12556 6-chloro-N-[(3S)-2-oxo-1-[2-oxo-2-(piperidin-1-yl)ethyl]pyrrolidin-3-yl]naphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 4 Coagulation factor X Homo sapiens 63 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12556&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646129 46513015 ZINC14950124 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22586 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCCCC1 InChI=1S/C22H26ClN3O4S/c1-15(21(27)25-10-3-2-4-11-25)26-12-9-20(22(26)28)24-31(29,30)19-8-6-16-13-18(23)7-5-17(16)14-19/h5-8,13-15,20,24H,2-4,9-12H2,1H3/t15-,20-/m0/s1 RFBGMIUDFJBOHN-YWZLYKJASA-N 12557 6-chloro-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(piperidin-1-yl)propan-2-yl]pyrrolidin-3-yl]naphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 5 Coagulation factor X Homo sapiens 1 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12557&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646130 46513016 ZINC14950127 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22587 C[C@H](N1CC[C@H](N(C)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCCCC1 InChI=1S/C23H28ClN3O4S/c1-16(22(28)26-11-4-3-5-12-26)27-13-10-21(23(27)29)25(2)32(30,31)20-9-7-17-14-19(24)8-6-18(17)15-20/h6-9,14-16,21H,3-5,10-13H2,1-2H3/t16-,21-/m0/s1 FZSKIUMTPMSWHZ-KKSFZXQISA-N 12558 6-chloro-N-methyl-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(piperidin-1-yl)propan-2-yl]pyrrolidin-3-yl]naphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 6 Coagulation factor X Homo sapiens 2 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12558&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646131 46513017 ZINC14950130 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22588 CC(C)(N1CCC(NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCCCC1 InChI=1S/C23H28ClN3O4S/c1-23(2,22(29)26-11-4-3-5-12-26)27-13-10-20(21(27)28)25-32(30,31)19-9-7-16-14-18(24)8-6-17(16)15-19/h6-9,14-15,20,25H,3-5,10-13H2,1-2H3 UWCFQUPDYZZTQW-UHFFFAOYSA-N 12559 6-chloro-N-{1-[2-methyl-1-oxo-1-(piperidin-1-yl)propan-2-yl]-2-oxopyrrolidin-3-yl}naphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 14 Coagulation factor X Homo sapiens 10600 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12559&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646132 46513018 ZINC14950136 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22589 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCCC1 InChI=1S/C21H24ClN3O4S/c1-14(20(26)24-9-2-3-10-24)25-11-8-19(21(25)27)23-30(28,29)18-7-5-15-12-17(22)6-4-16(15)13-18/h4-7,12-14,19,23H,2-3,8-11H2,1H3/t14-,19-/m0/s1 BPINZHBXUATCBJ-LIRRHRJNSA-N 12560 6-chloro-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]pyrrolidin-3-yl]naphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 19 Coagulation factor X Homo sapiens 50 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12560&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646133 46513019 ZINC14950140 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22590 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CC2CCC1CC2 InChI=1S/C24H28ClN3O4S/c1-15(23(29)28-14-16-2-7-20(28)8-3-16)27-11-10-22(24(27)30)26-33(31,32)21-9-5-17-12-19(25)6-4-18(17)13-21/h4-6,9,12-13,15-16,20,22,26H,2-3,7-8,10-11,14H2,1H3/t15-,16?,20?,22-/m0/s1 MZDNQHICNHGAOA-KNQAWESUSA-N 12561 N-[(3S)-1-[(2S)-1-{2-azabicyclo[2.2.2]octan-2-yl}-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-6-chloronaphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 20 Coagulation factor X Homo sapiens 3 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12561&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10141182 46513020 ZINC14950143 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22591 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1C[C@H]2CNC[C@H](C2)C1 InChI=1S/C24H29ClN4O4S/c1-15(23(30)28-13-16-8-17(14-28)12-26-11-16)29-7-6-22(24(29)31)27-34(32,33)21-5-3-18-9-20(25)4-2-19(18)10-21/h2-5,9-10,15-17,22,26-27H,6-8,11-14H2,1H3/t15-,16-,17+,22-/m0/s1 YWODBDBLLMXGRQ-FSTVOOFJSA-N 12562 6-chloro-N-[(3S)-1-[(2S)-1-[(1R,5S)-3,7-diazabicyclo[3.3.1]nonan-3-yl]-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 21 Coagulation factor X Homo sapiens 13 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12562&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23543689 46513021 ZINC34689226 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22592 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCNCC1 InChI=1S/C21H25ClN4O4S/c1-14(20(27)25-10-7-23-8-11-25)26-9-6-19(21(26)28)24-31(29,30)18-5-3-15-12-17(22)4-2-16(15)13-18/h2-5,12-14,19,23-24H,6-11H2,1H3/t14-,19-/m0/s1 OXYRWTWFZSETPA-LIRRHRJNSA-N 12563 6-chloro-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(piperazin-1-yl)propan-2-yl]pyrrolidin-3-yl]naphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 22 Coagulation factor X Homo sapiens 320 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12563&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646134 46513022 ZINC14950146 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22593 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCN(C)CC1 InChI=1S/C22H27ClN4O4S/c1-15(21(28)26-11-9-25(2)10-12-26)27-8-7-20(22(27)29)24-32(30,31)19-6-4-16-13-18(23)5-3-17(16)14-19/h3-6,13-15,20,24H,7-12H2,1-2H3/t15-,20-/m0/s1 JMIVLNOCPDITSR-YWZLYKJASA-N 12564 6-chloro-N-[(3S)-1-[(2S)-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 23 Coagulation factor X Homo sapiens 2060 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12564&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646135 46513023 ZINC14950150 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22594 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H24ClN3O5S/c1-14(20(26)24-8-10-30-11-9-24)25-7-6-19(21(25)27)23-31(28,29)18-5-3-15-12-17(22)4-2-16(15)13-18/h2-5,12-14,19,23H,6-11H2,1H3/t14-,19-/m0/s1 ICLOZQFWTRAYPX-LIRRHRJNSA-N 12538 6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1a::aminopyrrolidin-2-one 1::pyrrolidin-2-one-based inhibitor 24 Coagulation factor X Homo sapiens 6 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12538&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GSK 2CJI 6852168 46512997 DB07847 ZINC14950061 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22595 C[C@H](N1CC[C@H](N(C)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C22H26ClN3O5S/c1-15(21(27)25-9-11-31-12-10-25)26-8-7-20(22(26)28)24(2)32(29,30)19-6-4-16-13-18(23)5-3-17(16)14-19/h3-6,13-15,20H,7-12H2,1-2H3/t15-,20-/m0/s1 XDIZICJZQYNVHW-YWZLYKJASA-N 12566 6-chloro-N-methyl-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide::GTC000007A::pyrrolidin-2-one-based inhibitor 25 Coagulation factor X Homo sapiens 10 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12566&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10227632 46513024 ZINC14950153 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22596 C[C@H](N1CC[C@H](N(CC(O)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C23H26ClN3O7S/c1-15(22(30)25-8-10-34-11-9-25)26-7-6-20(23(26)31)27(14-21(28)29)35(32,33)19-5-3-16-12-18(24)4-2-17(16)13-19/h2-5,12-13,15,20H,6-11,14H2,1H3,(H,28,29)/t15-,20-/m0/s1 UAYCGHBBLVJXTC-YWZLYKJASA-N 12567 2-[(6-chloronaphthalene-2-)[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]sulfonamido]acetic acid::GTC000002A::pyrrolidin-2-one-based inhibitor 26 Coagulation factor X Homo sapiens 2 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12567&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10142920 46513025 ZINC14950158 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22597 C[C@H](N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C23H27ClN4O6S/c1-15(22(30)26-8-10-34-11-9-26)27-7-6-20(23(27)31)28(14-21(25)29)35(32,33)19-5-3-16-12-18(24)4-2-17(16)13-19/h2-5,12-13,15,20H,6-11,14H2,1H3,(H2,25,29)/t15-,20-/m0/s1 DRTYVXQQGDRUEW-YWZLYKJASA-N 12568 2-[(6-chloronaphthalene-2-)[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]sulfonamido]acetamide::GTC000005A::pyrrolidin-2-one-based inhibitor 27 Coagulation factor X Homo sapiens 3 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12568&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10301730 46513026 ZINC14950162 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22598 CCC(=O)CN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)c1ccc2cc(Cl)ccc2c1 InChI=1S/C25H30ClN3O6S/c1-3-21(30)16-29(36(33,34)22-7-5-18-14-20(26)6-4-19(18)15-22)23-8-9-28(25(23)32)17(2)24(31)27-10-12-35-13-11-27/h4-7,14-15,17,23H,3,8-13,16H2,1-2H3/t17-,23-/m0/s1 DSPUJUOXCWMCJY-SBUREZEXSA-N 12569 GTC000006A::N-(6-chloronaphthalen-2-yl)-N'-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-2-oxobutane-1-sulfonamido::pyrrolidin-2-one-based inhibitor 28 Coagulation factor X Homo sapiens 1 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12569&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10187006 46513027 ZINC14950166 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22599 C[C@@H](N1CC[C@@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H24ClN3O5S/c1-14(20(26)24-8-10-30-11-9-24)25-7-6-19(21(25)27)23-31(28,29)18-5-3-15-12-17(22)4-2-16(15)13-18/h2-5,12-14,19,23H,6-11H2,1H3/t14-,19-/m1/s1 ICLOZQFWTRAYPX-AUUYWEPGSA-N 12570 6-chloro-N-[(3R)-1-[(2R)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 32 Coagulation factor X Homo sapiens 82 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12570&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23644670 46509403 ZINC14950169 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22600 C[C@H](N1CC[C@@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H24ClN3O5S/c1-14(20(26)24-8-10-30-11-9-24)25-7-6-19(21(25)27)23-31(28,29)18-5-3-15-12-17(22)4-2-16(15)13-18/h2-5,12-14,19,23H,6-11H2,1H3/t14-,19+/m0/s1 ICLOZQFWTRAYPX-IFXJQAMLSA-N 12571 6-chloro-N-[(3R)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 33 Coagulation factor X Homo sapiens 53 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12571&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10162019 46513028 ZINC14950172 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22601 C[C@@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H24ClN3O5S/c1-14(20(26)24-8-10-30-11-9-24)25-7-6-19(21(25)27)23-31(28,29)18-5-3-15-12-17(22)4-2-16(15)13-18/h2-5,12-14,19,23H,6-11H2,1H3/t14-,19+/m1/s1 ICLOZQFWTRAYPX-KUHUBIRLSA-N 12572 6-chloro-N-[(3S)-1-[(2R)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 34 Coagulation factor X Homo sapiens 160 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12572&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646136 46513029 ZINC14950175 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22602 C[C@@H](N1CC[C@@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCCCC1 InChI=1S/C22H26ClN3O4S/c1-15(21(27)25-10-3-2-4-11-25)26-12-9-20(22(26)28)24-31(29,30)19-8-6-16-13-18(23)7-5-17(16)14-19/h5-8,13-15,20,24H,2-4,9-12H2,1H3/t15-,20-/m1/s1 RFBGMIUDFJBOHN-FOIQADDNSA-N 12573 6-chloro-N-[(3R)-2-oxo-1-[(2R)-1-oxo-1-(piperidin-1-yl)propan-2-yl]pyrrolidin-3-yl]naphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 35 Coagulation factor X Homo sapiens 40 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12573&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646137 46513030 ZINC14950178 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22603 C[C@H](N1CC[C@@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCCCC1 InChI=1S/C22H26ClN3O4S/c1-15(21(27)25-10-3-2-4-11-25)26-12-9-20(22(26)28)24-31(29,30)19-8-6-16-13-18(23)7-5-17(16)14-19/h5-8,13-15,20,24H,2-4,9-12H2,1H3/t15-,20+/m0/s1 RFBGMIUDFJBOHN-MGPUTAFESA-N 12574 6-chloro-N-[(3R)-2-oxo-1-[(2S)-1-oxo-1-(piperidin-1-yl)propan-2-yl]pyrrolidin-3-yl]naphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 36 Coagulation factor X Homo sapiens 16 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12574&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10183250 46513031 ZINC14950181 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22604 C[C@@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCCCC1 InChI=1S/C22H26ClN3O4S/c1-15(21(27)25-10-3-2-4-11-25)26-12-9-20(22(26)28)24-31(29,30)19-8-6-16-13-18(23)7-5-17(16)14-19/h5-8,13-15,20,24H,2-4,9-12H2,1H3/t15-,20+/m1/s1 RFBGMIUDFJBOHN-QRWLVFNGSA-N 12575 6-chloro-N-[(3S)-2-oxo-1-[(2R)-1-oxo-1-(piperidin-1-yl)propan-2-yl]pyrrolidin-3-yl]naphthalene-2-sulfonamide::pyrrolidin-2-one-based inhibitor 37 Coagulation factor X Homo sapiens 82 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.053 10.7270/Q2416V9V 16697194 aid1796916 Watson, NS; Brown, D; Campbell, M; Chan, C; Chaudry, L; Convery, MA; Fenwick, R; Hamblin, JN; Haslam, C; Kelly, HA; King, NP; Kurtis, CL; Leach, AR; Manchee, GR; Mason, AM; Mitchell, C; Patel, C; Patel, VK; Senger, S; Shah, GP; Weston, HE; Whitworth, C; Young, RJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12575&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646138 46513032 ZINC14950185 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23796 COc1ccc2ccc(cc2c1)S(=O)(=O)N(C)[C@H]1CCN(Cc2csc(c2)C(N)=N)C1=O InChI=1S/C22H24N4O4S2/c1-25(19-7-8-26(22(19)27)12-14-9-20(21(23)24)31-13-14)32(28,29)18-6-4-15-3-5-17(30-2)10-16(15)11-18/h3-6,9-11,13,19H,7-8,12H2,1-2H3,(H3,23,24)/t19-/m0/s1 YQYYTNCSSDRJHZ-IBGZPJMESA-N 13279 4-{[(3S)-3-[(7-methoxynaphthalene-2-)(methyl)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}thiophene-2-carboximidamide::4-{[(3S)-3-{[(7-methoxynaphthalen-2-yl)sulfonyl](methyl)amino}-2-oxopyrrolidin-1-yl]methyl}thiophene-2-carboximidamide::CHEMBL84638::RPR120844::Sulfonamidopyrrolidinone Coagulation factor X Homo sapiens 6.9 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13279&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10322586 46513687 CHEMBL84638 ZINC03985463 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23797 COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2cccc(c2)C(N)=N)C1=O InChI=1S/C23H24N4O4S/c1-31-19-7-5-16-6-8-20(13-18(16)12-19)32(29,30)26-21-9-10-27(23(21)28)14-15-3-2-4-17(11-15)22(24)25/h2-8,11-13,21,26H,9-10,14H2,1H3,(H3,24,25)/t21-/m0/s1 LDJWHJQMWPYZLV-NRFANRHFSA-N 13280 3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::CHEMBL327600::Sulfonamidopyrrolidinone 3a Coagulation factor X Homo sapiens 47 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13280&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9808035 46513688 CHEMBL327600 ZINC03936607 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23798 COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2cc(ccc2N)C(N)=N)C1=O InChI=1S/C23H25N5O4S/c1-32-18-5-2-14-3-6-19(12-16(14)11-18)33(30,31)27-21-8-9-28(23(21)29)13-17-10-15(22(25)26)4-7-20(17)24/h2-7,10-12,21,27H,8-9,13,24H2,1H3,(H3,25,26)/t21-/m0/s1 BKODMNIABFWKMF-NRFANRHFSA-N 13281 4-Amino-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfonylamino)-2-oxopyrrolidin-1-ylmethyl]benzamidine::4-amino-3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 4a Coagulation factor X Homo sapiens 6 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13281&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10837980 46513689 ZINC13800309 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23799 COc1ccc2ccc(cc2c1)S(=O)(=O)N(C)[C@H]1CCN(Cc2cccc(c2)C(N)=N)C1=O InChI=1S/C24H26N4O4S/c1-27(33(30,31)21-9-7-17-6-8-20(32-2)13-19(17)14-21)22-10-11-28(24(22)29)15-16-4-3-5-18(12-16)23(25)26/h3-9,12-14,22H,10-11,15H2,1-2H3,(H3,25,26)/t22-/m0/s1 BKGPGDSCCKKTNT-QFIPXVFZSA-N 13282 3-{[(3S)-3-[(7-methoxynaphthalene-2-)(methyl)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::CHEMBL333678::Sulfonamidopyrrolidinone 3b Coagulation factor X Homo sapiens 22 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13282&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10647907 46513690 CHEMBL333678 ZINC13800273 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23800 COc1ccc2ccc(cc2c1)S(=O)(=O)N(C)[C@H]1CCN(Cc2cc(ccc2N)C(N)=N)C1=O InChI=1S/C24H27N5O4S/c1-28(34(31,32)20-7-4-15-3-6-19(33-2)12-17(15)13-20)22-9-10-29(24(22)30)14-18-11-16(23(26)27)5-8-21(18)25/h3-8,11-13,22H,9-10,14,25H2,1-2H3,(H3,26,27)/t22-/m0/s1 YKNCZPHUMLXMOB-QFIPXVFZSA-N 13283 4-amino-3-({(3S)-3-[[(7-methoxy-2-naphthyl)sulfonyl](methyl)amino]-2-oxopyrrolidin-1-yl}methyl)benzenecarboximidamide::4-amino-3-{[(3S)-3-[(7-methoxynaphthalene-2-)(methyl)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 4b Coagulation factor X Homo sapiens 4 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13283&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10648454 46513691 ZINC13800311 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23801 COc1ccc2ccc(cc2c1)S(=O)(=O)N(C)[C@H]1CCN(Cc2cc(ccc2NC(C)=O)C(N)=N)C1=O InChI=1S/C26H29N5O5S/c1-16(32)29-23-9-6-18(25(27)28)12-20(23)15-31-11-10-24(26(31)33)30(2)37(34,35)22-8-5-17-4-7-21(36-3)13-19(17)14-22/h4-9,12-14,24H,10-11,15H2,1-3H3,(H3,27,28)(H,29,32)/t24-/m0/s1 XGLNNPQGQSORDQ-DEOSSOPVSA-N 13284 N-(4-carbamimidoyl-2-{[(3S)-3-[(7-methoxynaphthalene-2-)(methyl)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}phenyl)acetamide::N-[4-[amino(imino)methyl]-2-({(3S)-3-[[(7-methoxy-2-naphthyl)sulfonyl](methyl)amino]-2-oxopyrrolidin-1-yl}methyl)phenyl]acetamide::Sulfonamidopyrrolidinone 14 Coagulation factor X Homo sapiens 919 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13284&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10554052 46513692 ZINC13800313 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23802 COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2cc(N)cc(c2)C(N)=N)C1=O InChI=1S/C23H25N5O4S/c1-32-19-4-2-15-3-5-20(12-16(15)11-19)33(30,31)27-21-6-7-28(23(21)29)13-14-8-17(22(25)26)10-18(24)9-14/h2-5,8-12,21,27H,6-7,13,24H2,1H3,(H3,25,26)/t21-/m0/s1 QYBYIJVOSNTBCB-NRFANRHFSA-N 13285 3-Amino-5-[3-(S)-(7-methoxynaphthalen-2-ylsulfonylamino)-2-oxopyrrolidin-1-ylmethyl]benzamidine::3-amino-5-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 15 Coagulation factor X Homo sapiens 1200 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13285&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10600329 46513693 ZINC13800316 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23803 COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2cc(ccc2O)C(N)=N)C1=O InChI=1S/C23H24N4O5S/c1-32-18-5-2-14-3-6-19(12-16(14)11-18)33(30,31)26-20-8-9-27(23(20)29)13-17-10-15(22(24)25)4-7-21(17)28/h2-7,10-12,20,26,28H,8-9,13H2,1H3,(H3,24,25)/t20-/m0/s1 WYPLWOJSDQFHPG-FQEVSTJZSA-N 13286 4-Hydroxy-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfonylamino)-2-oxopyrrolidin-1-ylmethyl]benzamidine::4-hydroxy-3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::CHEMBL93854::Sulfonamidopyrrolidinone 20a Coagulation factor X Homo sapiens 3 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13286&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10790446 46513694 CHEMBL93854 ZINC03985467 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23804 COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2ccc(O)c(c2)C(N)=N)C1=O InChI=1S/C23H24N4O5S/c1-32-17-5-3-15-4-6-18(12-16(15)11-17)33(30,31)26-20-8-9-27(23(20)29)13-14-2-7-21(28)19(10-14)22(24)25/h2-7,10-12,20,26,28H,8-9,13H2,1H3,(H3,24,25)/t20-/m0/s1 HWDPXYCOPKIFNO-FQEVSTJZSA-N 13287 2-Hydroxy-5-[3-(S)-(7-methoxynaphthalen-2-ylsulfonylamino)-2-oxopyrrolidin-1-ylmethyl-]benzamidine::2-hydroxy-5-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 21 Coagulation factor X Homo sapiens 983 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13287&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10719094 46513695 ZINC13800319 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23805 COC(=O)COc1ccc(cc1CN1CC[C@H](NS(=O)(=O)c2ccc3ccc(OC)cc3c2)C1=O)C(N)=N InChI=1S/C26H28N4O7S/c1-35-20-6-3-16-4-7-21(13-18(16)12-20)38(33,34)29-22-9-10-30(26(22)32)14-19-11-17(25(27)28)5-8-23(19)37-15-24(31)36-2/h3-8,11-13,22,29H,9-10,14-15H2,1-2H3,(H3,27,28)/t22-/m0/s1 HHGGWCFPUIXQJD-QFIPXVFZSA-N 13288 Sulfonamidopyrrolidinone 27::methyl 2-(4-carbamimidoyl-2-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}phenoxy)acetate::{4-(Aminoiminomethyl)-2-[3-(S)-(7-methoxynaphthalen-2-ylsulfonylamino)-2-oxopyrrolidin-1-ylmethyl]phenoxy}acetic Acid Methyl Ester Coagulation factor X Homo sapiens 8 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13288&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10768801 46513696 ZINC14952232 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23806 COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2cc(ccc2OCC(O)=O)C(N)=N)C1=O InChI=1S/C25H26N4O7S/c1-35-19-5-2-15-3-6-20(12-17(15)11-19)37(33,34)28-21-8-9-29(25(21)32)13-18-10-16(24(26)27)4-7-22(18)36-14-23(30)31/h2-7,10-12,21,28H,8-9,13-14H2,1H3,(H3,26,27)(H,30,31)/t21-/m0/s1 LPWNNXLXMMTLKO-NRFANRHFSA-N 13289 2-(4-carbamimidoyl-2-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}phenoxy)acetic acid::Sulfonamidopyrrolidinone 28::{4-(Aminoiminomethyl)-2-[3-(S)-(7-methoxynaphthalen-2-ylsulfonylamino)-2-oxopyrrolidin-1-ylmethyl]phenoxy}acetic Acid Coagulation factor X Homo sapiens 1300 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13289&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10625945 46513697 ZINC14952237 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23807 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc(cc3)-c3ccccc3)C2=O)c1 InChI=1S/C24H24N4O3S/c25-23(26)20-8-4-5-17(15-20)16-28-14-13-22(24(28)29)27-32(30,31)21-11-9-19(10-12-21)18-6-2-1-3-7-18/h1-12,15,22,27H,13-14,16H2,(H3,25,26)/t22-/m0/s1 WQWOHPVWTNJMHH-QFIPXVFZSA-N 13290 3-{[(3S)-2-oxo-3-[(4-phenylbenzene)sulfonamido]pyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Biphenyl-4-sulfonic Acid {1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide::CHEMBL333548::Sulfonamidopyrrolidinone 3c Coagulation factor X Homo sapiens 160 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13290&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10694772 46513698 CHEMBL333548 ZINC12355223 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23808 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc(cc3)-c3ccccn3)C2=O)c1 InChI=1S/C23H23N5O3S/c24-22(25)18-5-3-4-16(14-18)15-28-13-11-21(23(28)29)27-32(30,31)19-9-7-17(8-10-19)20-6-1-2-12-26-20/h1-10,12,14,21,27H,11,13,15H2,(H3,24,25)/t21-/m0/s1 APOUXRBLXHMFLL-NRFANRHFSA-N 13291 3-{[(3S)-2-oxo-3-{[4-(pyridin-2-yl)benzene]sulfonamido}pyrrolidin-1-yl]methyl}benzene-1-carboximidamide::4-Pyridin-2-ylbenzenesulfonic Acid {1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide::Sulfonamidopyrrolidinone 3d Coagulation factor X Homo sapiens 150 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13291&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10742143 46513699 ZINC13800321 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23821 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc(cc3)-c3cccnc3)C2=O)c1 InChI=1S/C23H23N5O3S/c24-22(25)18-4-1-3-16(13-18)15-28-12-10-21(23(28)29)27-32(30,31)20-8-6-17(7-9-20)19-5-2-11-26-14-19/h1-9,11,13-14,21,27H,10,12,15H2,(H3,24,25)/t21-/m0/s1 QDOKOMIPDDUZIT-NRFANRHFSA-N 13292 3-{[(3S)-2-oxo-3-{[4-(pyridin-3-yl)benzene]sulfonamido}pyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 3e Coagulation factor X Homo sapiens 210 Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13292&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10671210 46513700 ZINC13800325 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23822 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc(cc3)-c3ccncc3)C2=O)c1 InChI=1S/C23H23N5O3S/c24-22(25)19-3-1-2-16(14-19)15-28-13-10-21(23(28)29)27-32(30,31)20-6-4-17(5-7-20)18-8-11-26-12-9-18/h1-9,11-12,14,21,27H,10,13,15H2,(H3,24,25)/t21-/m0/s1 JYJBKTYIKVXOEX-NRFANRHFSA-N 13293 3-{[(3S)-2-oxo-3-{[4-(pyridin-4-yl)benzene]sulfonamido}pyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 3f Coagulation factor X Homo sapiens 130 Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13293&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10765919 46513701 ZINC13800328 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23823 C[n+]1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H]1CCN(Cc2cccc(c2)C(N)=N)C1=O InChI=1S/C24H26N5O3S/c1-28-12-9-19(10-13-28)18-5-7-21(8-6-18)33(31,32)27-22-11-14-29(24(22)30)16-17-3-2-4-20(15-17)23(25)26/h2-10,12-13,15,22,27H,11,14,16H2,1H3,(H3,25,26)/q+1/t22-/m0/s1 IRSGJYQJVWYIOI-QFIPXVFZSA-N 13294 4-(4-{[(3S)-1-[(3-carbamimidoylphenyl)methyl]-2-oxopyrrolidin-3-yl]sulfamoyl}phenyl)-1-methylpyridin-1-ium::Sulfonamidopyrrolidinone 3g Coagulation factor X Homo sapiens >1000 Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13294&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10555769 46513702 ZINC13800355 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23824 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc(cc3)-c3cc[n+]([O-])cc3)C2=O)c1 InChI=1S/C23H23N5O4S/c24-22(25)19-3-1-2-16(14-19)15-27-11-10-21(23(27)29)26-33(31,32)20-6-4-17(5-7-20)18-8-12-28(30)13-9-18/h1-9,12-14,21,26H,10-11,15H2,(H3,24,25)/t21-/m0/s1 SZEXFVUBNSFXHR-NRFANRHFSA-N 13295 4-(4-{[(3S)-1-[(3-carbamimidoylphenyl)methyl]-2-oxopyrrolidin-3-yl]sulfamoyl}phenyl)-1-oxidopyridin-1-ium::Sulfonamidopyrrolidinone 3h Coagulation factor X Homo sapiens 330 Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13295&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10576138 46513703 ZINC13800331 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23825 Cn1ccnc1-c1ccc(cc1)S(=O)(=O)N[C@H]1CCN(Cc2cccc(c2)C(N)=N)C1=O InChI=1S/C22H24N6O3S/c1-27-12-10-25-21(27)16-5-7-18(8-6-16)32(30,31)26-19-9-11-28(22(19)29)14-15-3-2-4-17(13-15)20(23)24/h2-8,10,12-13,19,26H,9,11,14H2,1H3,(H3,23,24)/t19-/m0/s1 OIUQBFUDCXVJLM-IBGZPJMESA-N 13296 (1-Methyl-1H-imidazol-2-yl)benzene-4-sulfonic Acid {1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}-amide::3-{[(3S)-3-{[4-(1-methyl-1H-imidazol-2-yl)benzene]sulfonamido}-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 3i Coagulation factor X Homo sapiens 2600 Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13296&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10599734 46513704 ZINC13800334 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23826 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc(s3)-c3ccccn3)C2=O)c1 InChI=1S/C21H21N5O3S2/c22-20(23)15-5-3-4-14(12-15)13-26-11-9-17(21(26)27)25-31(28,29)19-8-7-18(30-19)16-6-1-2-10-24-16/h1-8,10,12,17,25H,9,11,13H2,(H3,22,23)/t17-/m0/s1 YYBTWQPBNZCADF-KRWDZBQOSA-N 13297 3-{[(3S)-2-oxo-3-{[5-(pyridin-2-yl)thiophene-2-]sulfonamido}pyrrolidin-1-yl]methyl}benzene-1-carboximidamide::5-Pyrid-2-ylthiophene-2-sulfonic Acid {1-[3-(Aminoiminomethyl)benzyl]-2-oxopyrrolidin-3-(S)-yl}amide::Sulfonamidopyrrolidinone 3j Coagulation factor X Homo sapiens 140 Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13297&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10503954 46513705 ZINC03827110 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23827 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc(s3)-c3cccnc3)C2=O)c1 InChI=1S/C21H21N5O3S2/c22-20(23)15-4-1-3-14(11-15)13-26-10-8-17(21(26)27)25-31(28,29)19-7-6-18(30-19)16-5-2-9-24-12-16/h1-7,9,11-12,17,25H,8,10,13H2,(H3,22,23)/t17-/m0/s1 REXYZGPCWMZGJE-KRWDZBQOSA-N 13298 3-[2-Oxo-3-(S)-(5-pyridin-3-ylthiophene-2-ylsulfonylamino)-pyrrolidin-1-ylmethyl]benzamidine::3-{[(3S)-2-oxo-3-{[5-(pyridin-3-yl)thiophene-2-]sulfonamido}pyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 3k Coagulation factor X Homo sapiens 41 Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13298&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10527751 46513706 ZINC13800336 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23828 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc(s3)-c3ccncc3)C2=O)c1 InChI=1S/C21H21N5O3S2/c22-20(23)16-3-1-2-14(12-16)13-26-11-8-17(21(26)27)25-31(28,29)19-5-4-18(30-19)15-6-9-24-10-7-15/h1-7,9-10,12,17,25H,8,11,13H2,(H3,22,23)/t17-/m0/s1 UOAUNXSBPSBSQS-KRWDZBQOSA-N 13299 3-[2-Oxo-3-(S)-(5-pyridin-4-ylthiophene-2-ylsulfonylamino)-pyrrolidin-1-ylmethyl]benzamidine::3-{[(3S)-2-oxo-3-{[5-(pyridin-4-yl)thiophene-2-]sulfonamido}pyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 3l Coagulation factor X Homo sapiens 55 Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13299&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10837478 46513707 ZINC03828592 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23829 COc1nccc(n1)-c1ccc(s1)S(=O)(=O)N[C@H]1CCN(Cc2cccc(c2)C(N)=N)C1=O InChI=1S/C21H22N6O4S2/c1-31-21-24-9-7-15(25-21)17-5-6-18(32-17)33(29,30)26-16-8-10-27(20(16)28)12-13-3-2-4-14(11-13)19(22)23/h2-7,9,11,16,26H,8,10,12H2,1H3,(H3,22,23)/t16-/m0/s1 IPTDWSONQGTYHA-INIZCTEOSA-N 13300 3-{[(3S)-3-{[5-(2-methoxypyrimidin-4-yl)thiophene-2-]sulfonamido}-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 3m Coagulation factor X Homo sapiens 150 Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13300&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10767268 46513708 ZINC13800339 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23830 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc(s3)-c3ccon3)C2=O)c1 InChI=1S/C19H19N5O4S2/c20-18(21)13-3-1-2-12(10-13)11-24-8-6-15(19(24)25)23-30(26,27)17-5-4-16(29-17)14-7-9-28-22-14/h1-5,7,9-10,15,23H,6,8,11H2,(H3,20,21)/t15-/m0/s1 GTGQWRBUKGBBTL-HNNXBMFYSA-N 13301 3-[3-(S)-(5-Isoxazol-3-ylthiophene-2-ylsulfonylamino)-2-oxopyrrolidin-1-ylmethyl]benzamidine::3-{[(3S)-3-{[5-(1,2-oxazol-3-yl)thiophene-2-]sulfonamido}-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 3n Coagulation factor X Homo sapiens 49 Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13301&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10813230 46513709 ZINC12355101 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23831 NC(=N)c1ccc(F)c(CN2CC[C@H](NS(=O)(=O)c3ccc(s3)-c3cccnc3)C2=O)c1 InChI=1S/C21H20FN5O3S2/c22-16-4-3-13(20(23)24)10-15(16)12-27-9-7-17(21(27)28)26-32(29,30)19-6-5-18(31-19)14-2-1-8-25-11-14/h1-6,8,10-11,17,26H,7,9,12H2,(H3,23,24)/t17-/m0/s1 BVWKXDHOFZQTMX-KRWDZBQOSA-N 13302 4-fluoro-3-[((3S)-2-oxo-3-{[(5-pyridin-3-ylthien-2-yl)sulfonyl]amino}pyrrolidin-1-yl)methyl]benzenecarboximidamide::4-fluoro-3-{[(3S)-2-oxo-3-{[5-(pyridin-3-yl)thiophene-2-]sulfonamido}pyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 29 Coagulation factor X Homo sapiens 130 Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13302&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10552445 46513710 ZINC13800341 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23832 NC(=N)c1ccc(N)c(CN2CC[C@H](NS(=O)(=O)c3ccc(s3)-c3cccnc3)C2=O)c1 InChI=1S/C21H22N6O3S2/c22-16-4-3-13(20(23)24)10-15(16)12-27-9-7-17(21(27)28)26-32(29,30)19-6-5-18(31-19)14-2-1-8-25-11-14/h1-6,8,10-11,17,26H,7,9,12,22H2,(H3,23,24)/t17-/m0/s1 OODAGDGRUVEJKE-KRWDZBQOSA-N 13303 4-Amino-3-[2-oxo-3-(S)-(5-pyridin-3-ylthiophene-2-ylsulfonylamino)pyrrolidin-1-ylmethyl]benzamidine::4-amino-3-{[(3S)-2-oxo-3-{[5-(pyridin-3-yl)thiophene-2-]sulfonamido}pyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 4c Coagulation factor X Homo sapiens 6.0 Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13303&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10624206 46513711 ZINC13800344 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23833 NC(=N)c1ccc(O)c(CN2CC[C@H](NS(=O)(=O)c3ccc(s3)-c3cccnc3)C2=O)c1 InChI=1S/C21H21N5O4S2/c22-20(23)13-3-4-17(27)15(10-13)12-26-9-7-16(21(26)28)25-32(29,30)19-6-5-18(31-19)14-2-1-8-24-11-14/h1-6,8,10-11,16,25,27H,7,9,12H2,(H3,22,23)/t16-/m0/s1 MKXLWSHXRLAPHM-INIZCTEOSA-N 13304 4-hydroxy-3-[((3S)-2-oxo-3-{[(5-pyridin-3-ylthien-2-yl)sulfonyl]amino}pyrrolidin-1-yl)methyl]benzenecarboximidamide::4-hydroxy-3-{[(3S)-2-oxo-3-{[5-(pyridin-3-yl)thiophene-2-]sulfonamido}pyrrolidin-1-yl]methyl}benzene-1-carboximidamide::RPR130737::Sulfonamidopyrrolidinone 20b Coagulation factor X Homo sapiens 2.0 Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13304&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9934465 46513712 ZINC03950795 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23834 NC(=N)c1ccc(N)c(CN2CC[C@H](NS(=O)(=O)c3ccc(s3)-c3ccon3)C2=O)c1 InChI=1S/C19H20N6O4S2/c20-13-2-1-11(18(21)22)9-12(13)10-25-7-5-15(19(25)26)24-31(27,28)17-4-3-16(30-17)14-6-8-29-23-14/h1-4,6,8-9,15,24H,5,7,10,20H2,(H3,21,22)/t15-/m0/s1 JZYCCVRLQKHTCR-HNNXBMFYSA-N 13305 4-Amino-3-[3-(S)-(5-isoxazol-3-ylthiophene-2-ylsulfonylamino)-2-oxopyrrolidin-1-ylmethyl]benzamidine::4-amino-3-{[(3S)-3-{[5-(1,2-oxazol-3-yl)thiophene-2-]sulfonamido}-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 4d Coagulation factor X Homo sapiens 7.0 Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13305&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10623842 46513713 ZINC13800347 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23835 NC(=N)c1ccc(O)c(CN2CC[C@H](NS(=O)(=O)c3ccc(s3)-c3ccon3)C2=O)c1 InChI=1S/C19H19N5O5S2/c20-18(21)11-1-2-15(25)12(9-11)10-24-7-5-14(19(24)26)23-31(27,28)17-4-3-16(30-17)13-6-8-29-22-13/h1-4,6,8-9,14,23,25H,5,7,10H2,(H3,20,21)/t14-/m0/s1 UPZCVHMIYOGCHJ-AWEZNQCLSA-N 13306 4-Hydroxy-3-[3-(S)-(5-isoxazol-3-ylthiophene-2-ylsulfonylamino)2-oxopyrrolidin-1-ylmethyl]benzamidine::4-hydroxy-3-{[(3S)-3-{[5-(1,2-oxazol-3-yl)thiophene-2-]sulfonamido}-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::Sulfonamidopyrrolidinone 20c Coagulation factor X Homo sapiens 3.0 Curated from the literature by BindingDB 10.1021/jm990041+ 10.7270/Q2KW5D9R 10479289 aid1797008 Choi-Sledeski, YM; McGarry, DG; Green, DM; Mason, HJ; Becker, MR; Davis, RS; Ewing, WR; Dankulich, WP; Manetta, VE; Morris, RL; Spada, AP; Cheney, DL; Brown, KD; Colussi, DJ; Chu, V; Heran, CL; Morgan, SR; Bentley, RG; Leadley, RJ; Maignan, S; Guilloteau, JP; Dunwiddie, CT; Pauls, HW Rhone-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13306&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10647701 46513714 ZINC13800352 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24915 COc1cccc2n(Cc3cccc(c3)C(N)=N)c(cc12)C(=O)NCc1ccc(cc1)[N+](C)(C)C InChI=1S/C28H31N5O2/c1-33(2,3)22-13-11-19(12-14-22)17-31-28(34)25-16-23-24(9-6-10-26(23)35-4)32(25)18-20-7-5-8-21(15-20)27(29)30/h5-16H,17-18H2,1-4H3,(H3-,29,30,31,34)/p+1 DDDMCGGVAQNMNT-UHFFFAOYSA-O 13893 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-4-methoxy-1H-indol-2-yl}formamido)methyl]-N,N,N-trimethylanilinium::3-amidinobenzylindole carboxamide 78 Coagulation factor X Homo sapiens 62 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13893&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9829805 46514271 ZINC13474319 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24916 C[N+](C)(C)c1ccc(CNC(=O)c2cc3cc(OCc4ccccc4)ccc3n2Cc2cccc(c2)C(N)=N)cc1 InChI=1S/C34H35N5O2/c1-39(2,3)29-14-12-24(13-15-29)21-37-34(40)32-20-28-19-30(41-23-25-8-5-4-6-9-25)16-17-31(28)38(32)22-26-10-7-11-27(18-26)33(35)36/h4-20H,21-23H2,1-3H3,(H3-,35,36,37,40)/p+1 UFKJQTGPBFWMGT-UHFFFAOYSA-O 13894 2,2,2-trifluoroacetate; 4-({[5-(benzyloxy)-1-[(3-carbamimidoylphenyl)methyl]-1H-indol-2-yl]formamido}methyl)-N,N,N-trimethylanilinium::3-amidinobenzylindole carboxamide 79 Coagulation factor X Homo sapiens 82 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13894&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search IMA 1LQE,1LPG 446978 46514272 DB02269 ZINC03815595 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24917 C[N+](C)(C)c1ccc(CNC(=O)c2cc3cc(F)ccc3n2Cc2cccc(c2)C(N)=N)cc1 InChI=1S/C27H28FN5O/c1-33(2,3)23-10-7-18(8-11-23)16-31-27(34)25-15-21-14-22(28)9-12-24(21)32(25)17-19-5-4-6-20(13-19)26(29)30/h4-15H,16-17H2,1-3H3,(H3-,29,30,31,34)/p+1 HUQHTHMQTZUEGK-UHFFFAOYSA-O 13895 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-5-fluoro-1H-indol-2-yl}formamido)methyl]-N,N,N-trimethylanilinium::3-amidinobenzylindole carboxamide 80 Coagulation factor X Homo sapiens 66 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13895&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11813821 46514273 ZINC13474320 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24918 C[N+](C)(C)c1ccc(CNC(=O)c2cc3cc(Cl)ccc3n2Cc2cccc(c2)C(N)=N)cc1 InChI=1S/C27H28ClN5O/c1-33(2,3)23-10-7-18(8-11-23)16-31-27(34)25-15-21-14-22(28)9-12-24(21)32(25)17-19-5-4-6-20(13-19)26(29)30/h4-15H,16-17H2,1-3H3,(H3-,29,30,31,34)/p+1 ZPWOHPSCGWSIDN-UHFFFAOYSA-O 13896 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-5-chloro-1H-indol-2-yl}formamido)methyl]-N,N,N-trimethylanilinium::3-amidinobenzylindole carboxamide 81 Coagulation factor X Homo sapiens 140 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13896&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11060982 46514274 ZINC13474321 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24919 C[N+](C)(C)c1ccc(CNC(=O)c2cc3cc(O)ccc3n2Cc2cccc(c2)C(N)=N)cc1 InChI=1S/C27H29N5O2/c1-32(2,3)22-9-7-18(8-10-22)16-30-27(34)25-15-21-14-23(33)11-12-24(21)31(25)17-19-5-4-6-20(13-19)26(28)29/h4-15H,16-17H2,1-3H3,(H4-,28,29,30,33,34)/p+1 RGYKPQLGQPKIEZ-UHFFFAOYSA-O 13897 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-5-hydroxy-1H-indol-2-yl}formamido)methyl]-N,N,N-trimethylanilinium::3-amidinobenzylindole carboxamide 82::CHEMBL306300 Coagulation factor X Homo sapiens 28 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13897&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10929854 46514275 CHEMBL306300 ZINC13474322 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24920 Cc1cccc2n(Cc3cccc(c3)C(N)=N)c(cc12)C(=O)NCc1ccc(cc1)[N+](C)(C)C InChI=1S/C28H31N5O/c1-19-7-5-10-25-24(19)16-26(32(25)18-21-8-6-9-22(15-21)27(29)30)28(34)31-17-20-11-13-23(14-12-20)33(2,3)4/h5-16H,17-18H2,1-4H3,(H3-,29,30,31,34)/p+1 WIMHXWXNMBNFDL-UHFFFAOYSA-O 13898 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-4-methyl-1H-indol-2-yl}formamido)methyl]-N,N,N-trimethylanilinium::3-amidinobenzylindole carboxamide 83 Coagulation factor X Homo sapiens 14 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13898&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11092975 46514276 ZINC01490439 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24921 C[N+](C)(C)c1ccc(CNC(=O)c2cc3cc(ccc3n2Cc2cccc(c2)C(N)=N)[N+]([O-])=O)cc1 InChI=1S/C27H28N6O3/c1-33(2,3)23-10-7-18(8-11-23)16-30-27(34)25-15-21-14-22(32(35)36)9-12-24(21)31(25)17-19-5-4-6-20(13-19)26(28)29/h4-15H,16-17H2,1-3H3,(H3-,28,29,30,34)/p+1 UNBRJUFLVAWRRR-UHFFFAOYSA-O 13899 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-5-nitro-1H-indol-2-yl}formamido)methyl]-N,N,N-trimethylanilinium::3-amidinobenzylindole carboxamide 84 Coagulation factor X Homo sapiens 144 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13899&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11814015 46514277 ZINC13474323 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22614 NC(=N)c1cccc(CN2CCN(CC2=O)S(=O)(=O)c2cc3ccc(Cl)cc3s2)c1 InChI=1S/C20H19ClN4O3S2/c21-16-5-4-14-9-19(29-17(14)10-16)30(27,28)25-7-6-24(18(26)12-25)11-13-2-1-3-15(8-13)20(22)23/h1-5,8-10H,6-7,11-12H2,(H3,22,23) PRMSFVUWLBPPLY-UHFFFAOYSA-N 12592 3-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE::3-({4-[(6-chloro-1-benzothiophene-2-)sulfonyl]-2-oxopiperazin-1-yl}methyl)benzene-1-carboximidamide::Ketopiperazine::RPR132747 Coagulation factor X Homo sapiens 18 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm0203837 10.7270/Q2VH5M2S 12593649 aid1796918 Maignan, S; Guilloteau, JP; Choi-Sledeski, YM; Becker, MR; Ewing, WR; Pauls, HW; Spada, AP; Mikol, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12592&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search RRP 1NFU 447359 46513048 DB08487 ZINC02047642 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22615 NC(=N)c1ccc(CN2CCN(CC2=O)S(=O)(=O)c2cc3ccc(Cl)cc3s2)cc1 InChI=1S/C20H19ClN4O3S2/c21-16-6-5-15-9-19(29-17(15)10-16)30(27,28)25-8-7-24(18(26)12-25)11-13-1-3-14(4-2-13)20(22)23/h1-6,9-10H,7-8,11-12H2,(H3,22,23) VXONTEUOQXFJJS-UHFFFAOYSA-N 12594 4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE::4-({4-[(6-chloro-1-benzothiophene-2-)sulfonyl]-2-oxopiperazin-1-yl}methyl)benzene-1-carboximidamide::CHEMBL48813::Ketopiperazine::RPR200095 Coagulation factor X Homo sapiens 1.3 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm0203837 10.7270/Q2VH5M2S 12593649 aid1796918 Maignan, S; Guilloteau, JP; Choi-Sledeski, YM; Becker, MR; Ewing, WR; Pauls, HW; Spada, AP; Mikol, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12594&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search RTR 1NFY 447362 46513049 CHEMBL48813 DB08495 ZINC02047636 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22616 OCCn1c(CN2CCN(CC2=O)S(=O)(=O)c2cc3ccc(Cl)cc3s2)cc2cnccc12 InChI=1S/C22H21ClN4O4S2/c23-17-2-1-15-10-22(32-20(15)11-17)33(30,31)26-6-5-25(21(29)14-26)13-18-9-16-12-24-4-3-19(16)27(18)7-8-28/h1-4,9-12,28H,5-8,13-14H2 NZNFLUOJACWZKX-UHFFFAOYSA-N 12595 4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-1-{[1-(2-HYDROXYETHYL)-1H-PYRROLO[3,2-C]PYRIDIN-2-YL]METHYL}PIPERAZIN-2-ONE::4-[(6-chloro-1-benzothiophene-2-)sulfonyl]-1-{[1-(2-hydroxyethyl)-1H-pyrrolo[3,2-c]pyridin-2-yl]methyl}piperazin-2-one::CHEMBL157813::Ketopiperazine::RPR208944 Coagulation factor X Homo sapiens 3.0 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm0203837 10.7270/Q2VH5M2S 12593649 aid1796918 Maignan, S; Guilloteau, JP; Choi-Sledeski, YM; Becker, MR; Ewing, WR; Pauls, HW; Spada, AP; Mikol, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12595&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search RDR 1NFX 447361 46513050 CHEMBL157813 ZINC02047638 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22617 Clc1ccc(C=CS(=O)(=O)N2CCN(Cc3cc4cnccc4[nH]3)C(=O)C2)s1 InChI=1S/C18H17ClN4O3S2/c19-17-2-1-15(27-17)4-8-28(25,26)23-7-6-22(18(24)12-23)11-14-9-13-10-20-5-3-16(13)21-14/h1-5,8-10,21H,6-7,11-12H2 PLWVUIRWJVKSSD-UHFFFAOYSA-N 12596 4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONE::4-{[(E)-2-(5-chlorothiophen-2-yl)ethene]sulfonyl}-1-{1H-pyrrolo[3,2-c]pyridin-2-ylmethyl}piperazin-2-one::CHEMBL423417::Ketopiperazine::RPR209685 Coagulation factor X Homo sapiens 1.1 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm0203837 10.7270/Q2VH5M2S 12593649 aid1796918 Maignan, S; Guilloteau, JP; Choi-Sledeski, YM; Becker, MR; Ewing, WR; Pauls, HW; Spada, AP; Mikol, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12596&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search RRR 1NFW 447360 46513051 CHEMBL423417 ZINC06183120 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22618 COC(=O)[C@H](Cc1cccc(c1)C(N)=N)[C@@H](C)NC(=O)c1ccc(cc1)-c1cccc(CN)c1 InChI=1S/C27H30N4O3/c1-17(24(27(33)34-2)15-18-5-3-8-23(13-18)25(29)30)31-26(32)21-11-9-20(10-12-21)22-7-4-6-19(14-22)16-28/h3-14,17,24H,15-16,28H2,1-2H3,(H3,29,30)(H,31,32)/t17-,24-/m1/s1 XFKVLKLCLYJKNF-MZNJEOGPSA-N 12597 CHEMBL48046::RPR128515::methyl (2R,3R)-2-{3-[amino(imino)methyl]benzyl}-3-({[3-(aminomethyl)-1,1-biphenyl-4-yl]carbonyl}amino)butanoate::methyl (2R,3R)-3-({4-[3-(aminomethyl)phenyl]phenyl}formamido)-2-[(3-carbamimidoylphenyl)methyl]butanoate Coagulation factor X Homo sapiens 0.9 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm0203837 10.7270/Q2VH5M2S 12593649 aid1796918 Maignan, S; Guilloteau, JP; Choi-Sledeski, YM; Becker, MR; Ewing, WR; Pauls, HW; Spada, AP; Mikol, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12597&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search RPR 1F0U,1EZQ 5497056 46513052 CHEMBL48046 DB04424 ZINC03815583 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22776 CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)c2cc(nn2-c2cccc(CN)c2)C(F)(F)F)c(F)c1 InChI=1S/C25H20F4N4O3S/c1-37(35,36)22-8-3-2-7-18(22)16-9-10-20(19(26)12-16)31-24(34)21-13-23(25(27,28)29)32-33(21)17-6-4-5-15(11-17)14-30/h2-13H,14,30H2,1H3,(H,31,34) ZLUOAFAJSUPHOG-UHFFFAOYSA-N 12657 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2-(methylsulfonyl)-[1,1-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::1-[3-(aminomethyl)phenyl]-N-[2-fluoro-4-(2-methanesulfonylphenyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::CHEMBL559015::DPC 423::DPC423 Coagulation factor X Homo sapiens 0.15 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12657&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search M35 3M35,3M36 9895762 46513110 CHEMBL559015 ZINC01490578 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22777 CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C25H17F4N5O4S/c1-39(36,37)21-5-3-2-4-15(21)13-6-8-18(17(26)10-13)31-24(35)19-12-22(25(27,28)29)32-34(19)14-7-9-20-16(11-14)23(30)33-38-20/h2-12H,1H3,(H2,30,33)(H,31,35) GTYYDEJOAHEDLZ-UHFFFAOYSA-N 12659 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[(2-methylsulfonyl-3-fluoro[1,1]biphen-4-yl)aminocarbonyl]-pyrazole, Trifluoroacetic Acid::1-(3-amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-(2-methanesulfonylphenyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; 2,2,2-trifluoroacetic acid::CHEMBL554926::Razaxaban Analogue::aminobenzisoxazole 38 Coagulation factor X Homo sapiens 0.09 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12659&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11479420 46513111 CHEMBL554926 ZINC14950374 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22778 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1S(N)(=O)=O)C(F)(F)F InChI=1S/C24H16F4N6O4S/c25-16-9-12(14-3-1-2-4-20(14)39(30,36)37)5-7-17(16)31-23(35)18-11-21(24(26,27)28)32-34(18)13-6-8-19-15(10-13)22(29)33-38-19/h1-11H,(H2,29,33)(H,31,35)(H2,30,36,37) QYJVSZKTSGFHME-UHFFFAOYSA-N 12660 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[(2-aminosulfonyl-3-fluoro[1,1]biphen-4-yl)aminocarbonyl]-pyrazole, Trifluoroacetic Acid Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-(2-sulfamoylphenyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; 2,2,2-trifluoroacetic acid::Razaxaban Analogue::aminobenzisoxazole 39 Coagulation factor X Homo sapiens 0.16 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12660&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11445304 46513112 ZINC14950377 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22779 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccncc1S(N)(=O)=O)C(F)(F)F InChI=1S/C23H15F4N7O4S/c24-15-7-11(13-5-6-30-10-19(13)39(29,36)37)1-3-16(15)31-22(35)17-9-20(23(25,26)27)32-34(17)12-2-4-18-14(8-12)21(28)33-38-18/h1-10H,(H2,28,33)(H,31,35)(H2,29,36,37) SIRYBZWAPDLBNE-UHFFFAOYSA-N 12661 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[[4-(2-aminosulfonyl-4-pyridinyl)-3-fluorophenyl]aminocarbonyl]pyrazole, Trifluoroacetic Acid Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-(3-sulfamoylpyridin-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; 2,2,2-trifluoroacetic acid::Razaxaban Analogue::aminobenzisoxazole 23 Coagulation factor X Homo sapiens 0.1 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12661&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11468062 46513113 ZINC14950380 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22780 Cn1ccnc1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C22H15F4N7O2/c1-32-7-6-28-20(32)11-2-4-15(14(23)8-11)29-21(34)16-10-18(22(24,25)26)30-33(16)12-3-5-17-13(9-12)19(27)31-35-17/h2-10H,1H3,(H2,27,31)(H,29,34) JBAZPOYGAUQDAO-UHFFFAOYSA-N 12662 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[4-(1-methylimidazol-2-yl)-2-fluorophenyl)aminocarbonyl]-Bis(trifluoroacetic acid) Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-(1-methyl-1H-imidazol-2-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; bis(2,2,2-trifluoroacetic acid)::Razaxaban Analogue::aminobenzisoxazole 28 Coagulation factor X Homo sapiens 0.51 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12662&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10140911 46513114 ZINC13611507 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22781 Cc1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C22H15F4N7O2/c1-11-28-6-7-32(11)12-2-4-16(15(23)9-12)29-21(34)17-10-19(22(24,25)26)30-33(17)13-3-5-18-14(8-13)20(27)31-35-18/h2-10H,1H3,(H2,27,31)(H,29,34) NSBCPJHADHWACD-UHFFFAOYSA-N 12663 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[4-(2-methylimidazol-1-yl)-2-fluorophenyl)aminocarbonyl]pyrazole, Bis(trifluoroacetic acid) Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-(2-methyl-1H-imidazol-1-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; bis(2,2,2-trifluoroacetic acid)::Razaxaban Analogue::aminobenzisoxazole 11a Coagulation factor X Homo sapiens 0.7 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12663&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11320069 46513115 ZINC13611509 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22782 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)C(=O)N1CCCC1)C(F)(F)F InChI=1S/C23H18F4N6O3/c24-15-9-12(22(35)32-7-1-2-8-32)3-5-16(15)29-21(34)17-11-19(23(25,26)27)30-33(17)13-4-6-18-14(10-13)20(28)31-36-18/h3-6,9-11H,1-2,7-8H2,(H2,28,31)(H,29,34) XFHPQLVMJVEBAR-UHFFFAOYSA-N 12664 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[2-fluoro-4-(N-pyrrolidinocarbonyl)phenylaminocarbonyl]-pyrazole Trifluoroacetate, Trifluoroacetic Acid Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-(pyrrolidin-1-ylcarbonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; 2,2,2-trifluoroacetic acid::Razaxaban Analogue::aminobenzisoxazole 40 Coagulation factor X Homo sapiens 0.92 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12664&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10164065 46513116 ZINC13611511 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22783 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)N1CCOCC1)C(F)(F)F InChI=1S/C22H18F4N6O3/c23-15-10-12(31-5-7-34-8-6-31)1-3-16(15)28-21(33)17-11-19(22(24,25)26)29-32(17)13-2-4-18-14(9-13)20(27)30-35-18/h1-4,9-11H,5-8H2,(H2,27,30)(H,28,33) IJULQVPTGWFUIR-UHFFFAOYSA-N 12665 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[(2-fluoro-4-morpholinophenyl)aminocarbonyl]pyrazole, Trifluoroacetic Acid salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-(morpholin-4-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; 2,2,2-trifluoroacetic acid::Razaxaban Analogue::aminobenzisoxazole 41 Coagulation factor X Homo sapiens 6.30 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12665&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10163421 46513117 ZINC13611512 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22784 Cc1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(c1)C#N InChI=1S/C23H15F3N8O2/c1-12-29-6-7-33(12)14-2-4-17(13(8-14)11-27)30-22(35)18-10-20(23(24,25)26)31-34(18)15-3-5-19-16(9-15)21(28)32-36-19/h2-10H,1H3,(H2,28,32)(H,30,35) KEOSSYBRTAEQPD-UHFFFAOYSA-N 12666 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[[(2-cyano-4-(2-methylimidazol-1-yl)phenyl]aminocarbonyl]-pyrazole, Bis(trifluoroacetic acid) Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-[2-cyano-4-(2-methyl-1H-imidazol-1-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; bis(2,2,2-trifluoroacetic acid)::Razaxaban Analogue::aminobenzisoxazole 42 Coagulation factor X Homo sapiens 0.52 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12666&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11468217 46513118 ZINC13611514 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22785 Cc1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)cc1 InChI=1S/C22H16F3N7O2/c1-12-27-8-9-31(12)14-4-2-13(3-5-14)28-21(33)17-11-19(22(23,24)25)29-32(17)15-6-7-18-16(10-15)20(26)30-34-18/h2-11H,1H3,(H2,26,30)(H,28,33) PYSZDOCTWCNJRK-UHFFFAOYSA-N 12667 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[4-(2-methylimidazol-1-yl)phenyl)aminocarbonyl]pyrazole, Bis(trifluoroacetic acid) Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; bis(2,2,2-trifluoroacetic acid)::Razaxaban Analogue::aminobenzisoxazole 43 Coagulation factor X Homo sapiens 0.6 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12667&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10183471 46513119 ZINC13611516 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22786 Cc1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(c1)-n1ccnc1C InChI=1S/C26H20F3N9O2/c1-14-31-7-9-36(14)16-3-5-19(20(12-16)37-10-8-32-15(37)2)33-25(39)21-13-23(26(27,28)29)34-38(21)17-4-6-22-18(11-17)24(30)35-40-22/h3-13H,1-2H3,(H2,30,35)(H,33,39) GIZJTKMNZOZPFC-UHFFFAOYSA-N 12668 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[[(2,4-bis-(2-methylimidazol-1-yl)phenyl]aminocarbonyl]pyrazole, Bis(trifluoroacetic acid) Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-[2,4-bis(2-methyl-1H-imidazol-1-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; bis(2,2,2-trifluoroacetic acid)::Razaxaban Analogue::aminobenzisoxazole 44 Coagulation factor X Homo sapiens 1.6 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12668&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646153 46513120 ZINC14950383 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22787 COc1cc(ccc1NC(=O)c1cc(nn1-c1ccc2onc(N)c2c1)C(F)(F)F)-n1ccnc1C InChI=1S/C23H18F3N7O3/c1-12-28-7-8-32(12)13-3-5-16(19(10-13)35-2)29-22(34)17-11-20(23(24,25)26)30-33(17)14-4-6-18-15(9-14)21(27)31-36-18/h3-11H,1-2H3,(H2,27,31)(H,29,34) MACXGBZRDGAVDN-UHFFFAOYSA-N 12669 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[[(2-methoxy-4-(2-methylimidazol-1-yl)phenyl]aminocarbonyl]pyrazole, Bis(trifluoroacetic acid) Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-[2-methoxy-4-(2-methyl-1H-imidazol-1-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; bis(2,2,2-trifluoroacetic acid)::Razaxaban Analogue::aminobenzisoxazole 45 Coagulation factor X Homo sapiens 2.8 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12669&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10141594 46513121 ZINC00583440 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22788 Cc1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(c1)C(N)=O InChI=1S/C23H17F3N8O3/c1-11-29-6-7-33(11)12-2-4-16(14(8-12)21(28)35)30-22(36)17-10-19(23(24,25)26)31-34(17)13-3-5-18-15(9-13)20(27)32-37-18/h2-10H,1H3,(H2,27,32)(H2,28,35)(H,30,36) XEHHJCXFVJSRRN-UHFFFAOYSA-N 12670 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[[(2-aminocarbonyl-4-(2-methylimidazol-1-yl)phenyl]aminocarbonyl]pyrazole, Bis(trifluoroacetic acid) Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-[2-carbamoyl-4-(2-methyl-1H-imidazol-1-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; bis(2,2,2-trifluoroacetic acid)::Razaxaban Analogue::aminobenzisoxazole 46 Coagulation factor X Homo sapiens 7.7 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12670&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11434124 46513122 ZINC13611517 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22789 CCc1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C23H17F4N7O2/c1-2-20-29-7-8-33(20)12-3-5-16(15(24)10-12)30-22(35)17-11-19(23(25,26)27)31-34(17)13-4-6-18-14(9-13)21(28)32-36-18/h3-11H,2H2,1H3,(H2,28,32)(H,30,35) PNEWMVVHZXAPHB-UHFFFAOYSA-N 12671 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[[4-(2-ethylimidazol-1-yl)-2-fluorophenyl]aminocarbonyl]-pyrazole, Bis(trifluoroacetic acid) Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-[4-(2-ethyl-1H-imidazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; bis(2,2,2-trifluoroacetic acid)::Razaxaban Analogue::aminobenzisoxazole 11b Coagulation factor X Homo sapiens 0.73 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12671&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10141691 46513123 ZINC00593666 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22790 CC(C)c1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C24H19F4N7O2/c1-12(2)22-30-7-8-34(22)13-3-5-17(16(25)10-13)31-23(36)18-11-20(24(26,27)28)32-35(18)14-4-6-19-15(9-14)21(29)33-37-19/h3-12H,1-2H3,(H2,29,33)(H,31,36) XJFWVELXUFRWHB-UHFFFAOYSA-N 12672 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-5-[[4-(2-isopropylimidazol-1-yl)-2-fluorophenyl]aminocarbonyl]pyrazole, Bis(trifluoroacetic acid) Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-{2-fluoro-4-[2-(propan-2-yl)-1H-imidazol-1-yl]phenyl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; bis(2,2,2-trifluoroacetic acid)::Razaxaban Analogue::aminobenzisoxazole 11c Coagulation factor X Homo sapiens 1.6 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12672&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10207853 46513124 ZINC13611519 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22791 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1ccnc1CO)C(F)(F)F InChI=1S/C22H15F4N7O3/c23-14-8-11(32-6-5-28-19(32)10-34)1-3-15(14)29-21(35)16-9-18(22(24,25)26)30-33(16)12-2-4-17-13(7-12)20(27)31-36-17/h1-9,34H,10H2,(H2,27,31)(H,29,35) PNIJAJQGAGODFB-UHFFFAOYSA-N 12673 1-(3-amino-1,2-benzoxazol-5-yl)-N-{2-fluoro-4-[2-(hydroxymethyl)-1H-imidazol-1-yl]phenyl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; 2,2,2-trifluoroacetic acid::N-[4-(2-[Hydroxymethyl]-1H-imidazol-1-yl)-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Razaxaban Analogue::aminobenzisoxazole 35 Coagulation factor X Homo sapiens 1.0 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12673&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11433511 46513125 ZINC13611521 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22792 NCc1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C22H16F4N8O2/c23-14-8-11(33-6-5-29-19(33)10-27)1-3-15(14)30-21(35)16-9-18(22(24,25)26)31-34(16)12-2-4-17-13(7-12)20(28)32-36-17/h1-9H,10,27H2,(H2,28,32)(H,30,35) JPKDFYYSRDZYIY-UHFFFAOYSA-N 12674 1-(3-amino-1,2-benzoxazol-5-yl)-N-{4-[2-(aminomethyl)-1H-imidazol-1-yl]-2-fluorophenyl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; bis(2,2,2-trifluoroacetic acid)::N-[4-(2-[Aminomethyl]-1H-imidazol-1-yl)-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide, Bis(trifluoroacetic acid) Salt::Razaxaban Analogue::aminobenzisoxazole 37 Coagulation factor X Homo sapiens 3.0 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12674&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10217801 46513126 ZINC13611522 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22793 CNCc1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C23H18F4N8O2/c1-29-11-20-30-6-7-34(20)12-2-4-16(15(24)9-12)31-22(36)17-10-19(23(25,26)27)32-35(17)13-3-5-18-14(8-13)21(28)33-37-18/h2-10,29H,11H2,1H3,(H2,28,33)(H,31,36) XHPFWZMUFYSOAQ-UHFFFAOYSA-N 12675 1-(3-amino-1,2-benzoxazol-5-yl)-N-(2-fluoro-4-{2-[(methylamino)methyl]-1H-imidazol-1-yl}phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; bis(2,2,2-trifluoroacetic acid)::N-[4-(2-{[Methylamino]methyl}-1H-imidazol-1-yl)-2-fluorophenyl]-1-(3-amino-1,2-benzisoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide, Bis(trifluoroacetic acid) Salt::Razaxaban Analogue::aminobenzisoxazole 12 Coagulation factor X Homo sapiens 0.17 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12675&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10239342 46513127 ZINC13611524 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22794 CN(C)Cc1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C24H20F4N8O2/c1-34(2)12-21-30-7-8-35(21)13-3-5-17(16(25)10-13)31-23(37)18-11-20(24(26,27)28)32-36(18)14-4-6-19-15(9-14)22(29)33-38-19/h3-11H,12H2,1-2H3,(H2,29,33)(H,31,37) OFJRNBWSFXEHSA-UHFFFAOYSA-N 12676 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[2-fluoro-4-[(2-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::BMS-561389::CHEMBL206335::CHEMBL558198::DPC 906::Razaxaban Coagulation factor X Homo sapiens 0.19 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12676&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search IK8 1Z6E 204102 46513128 CHEMBL206335CHEMBL558198 ZINC03633839 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22795 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1ccnc1CN1CCCC1)C(F)(F)F InChI=1S/C26H22F4N8O2/c27-18-12-15(37-10-7-32-23(37)14-36-8-1-2-9-36)3-5-19(18)33-25(39)20-13-22(26(28,29)30)34-38(20)16-4-6-21-17(11-16)24(31)35-40-21/h3-7,10-13H,1-2,8-9,14H2,(H2,31,35)(H,33,39) GONSXYIFCYXXJP-UHFFFAOYSA-N 12677 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[2-fluoro-4-[(2-pyrrolidinylmethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide, Bis(trifluoroacetic acid), Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-{2-fluoro-4-[2-(pyrrolidin-1-ylmethyl)-1H-imidazol-1-yl]phenyl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide; bis(2,2,2-trifluoroacetic acid)::Razaxaban Analogue::aminobenzisoxazole 11e Coagulation factor X Homo sapiens 0.37 7 22.00 C Curated from the literature by BindingDB 10.1021/jm0497949 10.7270/Q2BK19K9 15771420 aid1796932 Quan, ML; Lam, PY; Han, Q; Pinto, DJ; He, MY; Li, R; Ellis, CD; Clark, CG; Teleha, CA; Sun, JH; Alexander, RS; Bai, S; Luettgen, JM; Knabb, RM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12677&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11181893 46513129 ZINC14950386 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25109 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1ccccc1O InChI=1S/C14H12N4O/c15-13(16)8-5-6-10-11(7-8)18-14(17-10)9-3-1-2-4-12(9)19/h1-7,19H,(H3,15,16)(H,17,18)/p+1 URJKRCBBKTXOHS-UHFFFAOYSA-O 13937 2-(2-HYDROXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE::APC-1144::{amino[2-(2-hydroxyphenyl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 2000 Curated from the literature by BindingDB 10.1006/jmbi.2001.4516 10.7270/Q2FX77PG 11292354 aid1797113 Katz, BA; Elrod, K; Luong, C; Rice, MJ; Mackman, RL; Sprengeler, PA; Spencer, J; Hataye, J; Janc, J; Link, J; Litvak, J; Rai, R; Rice, K; Sideris, S; Verner, E; Young, W Axys Pharmaceuticals Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13937&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 122 1GI2,1GI4 5353306 46514312 DB02287 ZINC31976714 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25110 COc1ccc(O)c(c1)-c1nc2ccc(cc2[nH]1)C(N)=[NH2+] InChI=1S/C15H14N4O2/c1-21-9-3-5-13(20)10(7-9)15-18-11-4-2-8(14(16)17)6-12(11)19-15/h2-7,20H,1H3,(H3,16,17)(H,18,19)/p+1 ZFCKHJJALHETHG-UHFFFAOYSA-O 13939 2-(2-HYDROXY-5-METHOXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE::APC-6669::{amino[2-(2-hydroxy-5-methoxyphenyl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 4600 Curated from the literature by BindingDB 10.1006/jmbi.2001.4516 10.7270/Q2FX77PG 11292354 aid1797113 Katz, BA; Elrod, K; Luong, C; Rice, MJ; Mackman, RL; Sprengeler, PA; Spencer, J; Hataye, J; Janc, J; Link, J; Litvak, J; Rai, R; Rice, K; Sideris, S; Verner, E; Young, W Axys Pharmaceuticals Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13939&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1GI5,1GI9 5353303 46514313 ZINC13863689 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25111 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1cc(ccc1O)[N+]([O-])=O InChI=1S/C14H11N5O3/c15-13(16)7-1-3-10-11(5-7)18-14(17-10)9-6-8(19(21)22)2-4-12(9)20/h1-6,20H,(H3,15,16)(H,17,18)/p+1 XDLJIVLILSOHRM-UHFFFAOYSA-O 13941 APC-8249::{amino[2-(2-hydroxy-5-nitrophenyl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 2700 Curated from the literature by BindingDB 10.1006/jmbi.2001.4516 10.7270/Q2FX77PG 11292354 aid1797113 Katz, BA; Elrod, K; Luong, C; Rice, MJ; Mackman, RL; Sprengeler, PA; Spencer, J; Hataye, J; Janc, J; Link, J; Litvak, J; Rai, R; Rice, K; Sideris, S; Verner, E; Young, W Axys Pharmaceuticals Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13941&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646553 46514315 ZINC13863686 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25112 NC(=[NH2+])c1ccc2[nH]c(cc2c1)-c1ccccc1O InChI=1S/C15H13N3O/c16-15(17)9-5-6-12-10(7-9)8-13(18-12)11-3-1-2-4-14(11)19/h1-8,18-19H,(H3,16,17)/p+1 JPGNPKIYCTXJPG-UHFFFAOYSA-O 13942 2-(2-HYDROXY-PHENYL)-1H-INDOLE-5-CARBOXAMIDINE::APC-8328::{amino[2-(2-hydroxyphenyl)-1H-indol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 740 Curated from the literature by BindingDB 10.1006/jmbi.2001.4516 10.7270/Q2FX77PG 11292354 aid1797113 Katz, BA; Elrod, K; Luong, C; Rice, MJ; Mackman, RL; Sprengeler, PA; Spencer, J; Hataye, J; Janc, J; Link, J; Litvak, J; Rai, R; Rice, K; Sideris, S; Verner, E; Young, W Axys Pharmaceuticals Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13942&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 124 1GI6 1507 46514316 DB02463 ZINC03591066 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25113 COc1ccccc1-c1nc2ccc(cc2[nH]1)C(N)=[NH2+] InChI=1S/C15H14N4O/c1-20-13-5-3-2-4-10(13)15-18-11-7-6-9(14(16)17)8-12(11)19-15/h2-8H,1H3,(H3,16,17)(H,18,19)/p+1 FSIIIUKPMNRIFF-UHFFFAOYSA-O 13943 APC-1847::{amino[2-(2-methoxyphenyl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 17000 Curated from the literature by BindingDB 10.1006/jmbi.2001.4516 10.7270/Q2FX77PG 11292354 aid1797113 Katz, BA; Elrod, K; Luong, C; Rice, MJ; Mackman, RL; Sprengeler, PA; Spencer, J; Hataye, J; Janc, J; Link, J; Litvak, J; Rai, R; Rice, K; Sideris, S; Verner, E; Young, W Axys Pharmaceuticals Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13943&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646554 46514317 ZINC14954133 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25114 NC(=[NH2+])c1ccccc1 InChI=1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9)/p+1 PXXJHWLDUBFPOL-UHFFFAOYSA-O 772 Benzamidine::CHEMBL79897::[amino(phenyl)methylidene]azanium::benzamidine deriv.::benzamidinium chloride Coagulation factor X Homo sapiens 165000 Curated from the literature by BindingDB 10.1006/jmbi.2001.4516 10.7270/Q2FX77PG 11292354 aid1797113 Katz, BA; Elrod, K; Luong, C; Rice, MJ; Mackman, RL; Sprengeler, PA; Spencer, J; Hataye, J; Janc, J; Link, J; Litvak, J; Rai, R; Rice, K; Sideris, S; Verner, E; Young, W Axys Pharmaceuticals Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search BAM 5AUI,1C5O,1C5Z,1C5P,5Z87,5YX6,3PCZ,5NVJ,3PVK,4OMR,5MOQ,6JO2,1TIO,4J2S,5MNH,5MNG,4IZX,6I44,5MO0,1ZVW,6S32,1HJ8,6Q39,6Q37,1XX4,2PSM,1F5K,4XN6,5JD4,4P9H,5PB1,2BY9,2BY8,2BY7,2BY6,2BY5,2BYA,1C1N,2ANW,2ANY 444655 11108095 41033 CHEMBL79897 DB03127 C01784 ZINC00036634 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25115 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1ccccc1O InChI=1S/C14H12N4O/c15-13(16)8-5-6-10-11(7-8)18-14(17-10)9-3-1-2-4-12(9)19/h1-7,19H,(H3,15,16)(H,17,18)/p+1 URJKRCBBKTXOHS-UHFFFAOYSA-O 13937 2-(2-HYDROXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE::APC-1144::{amino[2-(2-hydroxyphenyl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 280 Curated from the literature by BindingDB 10.1006/jmbi.2001.4516 10.7270/Q2FX77PG 11292354 aid1797113 Katz, BA; Elrod, K; Luong, C; Rice, MJ; Mackman, RL; Sprengeler, PA; Spencer, J; Hataye, J; Janc, J; Link, J; Litvak, J; Rai, R; Rice, K; Sideris, S; Verner, E; Young, W Axys Pharmaceuticals Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13937&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 122 1GI2,1GI4 5353306 46514312 DB02287 ZINC31976714 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25116 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1ncccc1O InChI=1S/C13H11N5O/c14-12(15)7-3-4-8-9(6-7)18-13(17-8)11-10(19)2-1-5-16-11/h1-6,19H,(H3,14,15)(H,17,18)/p+1 FQCDQFDJHSXQKY-UHFFFAOYSA-O 13940 2-(3-HYDROXY-PYRIDIN-2-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE::APC-1801::{amino[2-(3-hydroxypyridin-2-yl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 17 Curated from the literature by BindingDB 10.1006/jmbi.2001.4516 10.7270/Q2FX77PG 11292354 aid1797113 Katz, BA; Elrod, K; Luong, C; Rice, MJ; Mackman, RL; Sprengeler, PA; Spencer, J; Hataye, J; Janc, J; Link, J; Litvak, J; Rai, R; Rice, K; Sideris, S; Verner, E; Young, W Axys Pharmaceuticals Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13940&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1GHY,1O31,1O32,1O33,1O34 5326681 46514314 ZINC18163907 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25117 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1ncccc1O InChI=1S/C13H11N5O/c14-12(15)7-3-4-8-9(6-7)18-13(17-8)11-10(19)2-1-5-16-11/h1-6,19H,(H3,14,15)(H,17,18)/p+1 FQCDQFDJHSXQKY-UHFFFAOYSA-O 13940 2-(3-HYDROXY-PYRIDIN-2-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE::APC-1801::{amino[2-(3-hydroxypyridin-2-yl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 4500 Curated from the literature by BindingDB 10.1006/jmbi.2001.4516 10.7270/Q2FX77PG 11292354 aid1797113 Katz, BA; Elrod, K; Luong, C; Rice, MJ; Mackman, RL; Sprengeler, PA; Spencer, J; Hataye, J; Janc, J; Link, J; Litvak, J; Rai, R; Rice, K; Sideris, S; Verner, E; Young, W Axys Pharmaceuticals Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13940&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1GHY,1O31,1O32,1O33,1O34 5326681 46514314 ZINC18163907 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22834 CN(C)Cc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1ccc2onc(N)c2c1)C(F)(F)F InChI=1S/C29H25F3N6O2/c1-36(2)16-18-5-3-4-6-21(18)17-7-9-19(10-8-17)37-14-13-22-25(28(37)39)38(34-26(22)29(30,31)32)20-11-12-24-23(15-20)27(33)35-40-24/h3-12,15H,13-14,16H2,1-2H3,(H2,33,35) GJINLTTVIZRYJU-UHFFFAOYSA-N 12681 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 6a::bicyclic pyrazole scaffold::dihydropyrazolopyridinone analogue 9 Coagulation factor X Homo sapiens 0.04 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12681&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086976 46513130 ZINC14950399 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22835 CN(C)Cc1ccccc1-c1ccc(N2CCc3c(nn(c3C2=O)-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C29H24F4N6O2/c1-37(2)15-17-5-3-4-6-19(17)16-7-9-23(22(30)13-16)38-12-11-20-25(28(38)40)39(35-26(20)29(31,32)33)18-8-10-24-21(14-18)27(34)36-41-24/h3-10,13-14H,11-12,15H2,1-2H3,(H2,34,36) DXMUOXUECGPKKS-UHFFFAOYSA-N 12682 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]phenyl}-2-fluorophenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 7a::bicyclic pyrazole scaffold Coagulation factor X Homo sapiens 0.13 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12682&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646154 46513131 ZINC14950402 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22836 CN(C)Cc1ccccc1-c1ccc(cc1)N1CCCc2c(nn(c2C1=O)-c1ccc2onc(N)c2c1)C(F)(F)F InChI=1S/C30H27F3N6O2/c1-37(2)17-19-6-3-4-7-22(19)18-9-11-20(12-10-18)38-15-5-8-23-26(29(38)40)39(35-27(23)30(31,32)33)21-13-14-25-24(16-21)28(34)36-41-25/h3-4,6-7,9-14,16H,5,8,15,17H2,1-2H3,(H2,34,36) REMQJEJXBDQPFM-UHFFFAOYSA-N 12683 1-(3-amino-1,2-benzoxazol-5-yl)-7-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H,8H-pyrazolo[3,4-c]azepin-8-one::BMS-740808 Analogue 16a::bicyclic pyrazole scaffolds Coagulation factor X Homo sapiens 0.81 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12683&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22087007 46513132 ZINC14950404 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22837 CN(C)Cc1ccccc1-c1ccc(N2CCCc3c(nn(c3C2=O)-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C30H26F4N6O2/c1-38(2)16-18-6-3-4-7-20(18)17-9-11-24(23(31)14-17)39-13-5-8-21-26(29(39)41)40(36-27(21)30(32,33)34)19-10-12-25-22(15-19)28(35)37-42-25/h3-4,6-7,9-12,14-15H,5,8,13,16H2,1-2H3,(H2,35,37) SFHOYYLXQXCOQP-UHFFFAOYSA-N 12684 1-(3-amino-1,2-benzoxazol-5-yl)-7-(4-{2-[(dimethylamino)methyl]phenyl}-2-fluorophenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H,8H-pyrazolo[3,4-c]azepin-8-one::BMS-740808 Analogue 16b::bicyclic pyrazole scaffold Coagulation factor X Homo sapiens 0.85 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12684&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22087006 46513133 ZINC14950407 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22838 CN(C)Cc1ccccc1-c1ccc(cc1)N1CC=Cc2c(nn(c2C1=O)-c1ccc2onc(N)c2c1)C(F)(F)F InChI=1S/C30H25F3N6O2/c1-37(2)17-19-6-3-4-7-22(19)18-9-11-20(12-10-18)38-15-5-8-23-26(29(38)40)39(35-27(23)30(31,32)33)21-13-14-25-24(16-21)28(34)36-41-25/h3-14,16H,15,17H2,1-2H3,(H2,34,36) KCFMODQXICCLMX-UHFFFAOYSA-N 12685 1-(3-amino-1,2-benzoxazol-5-yl)-7-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,6H,7H,8H-pyrazolo[3,4-c]azepin-8-one::BMS-740808 Analogue 17a::bicyclic pyrazole scaffold Coagulation factor X Homo sapiens 0.6 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12685&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20760216 46513134 ZINC14950410 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22839 CN(C)Cc1ccccc1-c1ccc(N2CC=Cc3c(nn(c3C2=O)-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C30H24F4N6O2/c1-38(2)16-18-6-3-4-7-20(18)17-9-11-24(23(31)14-17)39-13-5-8-21-26(29(39)41)40(36-27(21)30(32,33)34)19-10-12-25-22(15-19)28(35)37-42-25/h3-12,14-15H,13,16H2,1-2H3,(H2,35,37) MZRBGTNVLDWXCY-UHFFFAOYSA-N 12686 1-(3-amino-1,2-benzoxazol-5-yl)-7-(4-{2-[(dimethylamino)methyl]phenyl}-2-fluorophenyl)-3-(trifluoromethyl)-1H,6H,7H,8H-pyrazolo[3,4-c]azepin-8-one::BMS-740808 Analogue 17b::bicyclic pyrazole scaffold Coagulation factor X Homo sapiens 0.6 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12686&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20760215 46513135 ZINC14950413 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22840 CN(C)Cc1ccccc1-c1ccc(cc1)N1CNc2c(nn(c2C1=O)-c1ccc2onc(N)c2c1)C(F)(F)F InChI=1S/C28H24F3N7O2/c1-36(2)14-17-5-3-4-6-20(17)16-7-9-18(10-8-16)37-15-33-23-24(27(37)39)38(34-25(23)28(29,30)31)19-11-12-22-21(13-19)26(32)35-40-22/h3-13,33H,14-15H2,1-2H3,(H2,32,35) WNKVDNSACGSTII-UHFFFAOYSA-N 12687 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::BMS-740808 Analogue 18::dihydropyrazolo[4,3-d]pyrimidinone 24a Coagulation factor X Homo sapiens 0.25 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12687&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086975 46513136 ZINC14950416 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22841 CN(C)Cc1ccccc1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C27H22F4N6O2/c1-36(2)14-16-5-3-4-6-18(16)15-7-9-21(20(28)11-15)33-26(38)22-13-24(27(29,30)31)34-37(22)17-8-10-23-19(12-17)25(32)35-39-23/h3-13H,14H2,1-2H3,(H2,32,35)(H,33,38) LDUWBIVGHVTDNA-UHFFFAOYSA-N 12688 1-(3-amino-1,2-benzoxazol-5-yl)-N-(4-{2-[(dimethylamino)methyl]phenyl}-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2g::BMS-740808 Analogue 15 Coagulation factor X Homo sapiens 0.26 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12688&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10143532 46513137 ZINC14950419 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22842 CN(C)Cc1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C24H20F4N8O2/c1-34(2)12-21-30-7-8-35(21)13-3-5-17(16(25)10-13)31-23(37)18-11-20(24(26,27)28)32-36(18)14-4-6-19-15(9-14)22(29)33-38-19/h3-11H,12H2,1-2H3,(H2,29,33)(H,31,37) OFJRNBWSFXEHSA-UHFFFAOYSA-N 12676 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[2-fluoro-4-[(2-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::BMS-561389::CHEMBL206335::CHEMBL558198::DPC 906::Razaxaban Coagulation factor X Homo sapiens 0.19 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12676&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search IK8 1Z6E 204102 46513128 CHEMBL206335CHEMBL558198 ZINC03633839 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22843 CCN(CC)Cc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1ccc2onc(N)c2c1)C(F)(F)F InChI=1S/C31H29F3N6O2/c1-3-38(4-2)18-20-7-5-6-8-23(20)19-9-11-21(12-10-19)39-16-15-24-27(30(39)41)40(36-28(24)31(32,33)34)22-13-14-26-25(17-22)29(35)37-42-26/h5-14,17H,3-4,15-16,18H2,1-2H3,(H2,35,37) UKWUFMOOIOETEJ-UHFFFAOYSA-N 12689 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(diethylamino)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 6b::bicyclic pyrazole scaffold Coagulation factor X Homo sapiens 0.11 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12689&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646155 46513138 ZINC14950422 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22844 CCN(C)Cc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1ccc2onc(N)c2c1)C(F)(F)F InChI=1S/C30H27F3N6O2/c1-3-37(2)17-19-6-4-5-7-22(19)18-8-10-20(11-9-18)38-15-14-23-26(29(38)40)39(35-27(23)30(31,32)33)21-12-13-25-24(16-21)28(34)36-41-25/h4-13,16H,3,14-15,17H2,1-2H3,(H2,34,36) OKBAPMZESMJOQK-UHFFFAOYSA-N 12690 1-(3-amino-1,2-benzoxazol-5-yl)-6-[4-(2-{[ethyl(methyl)amino]methyl}phenyl)phenyl]-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 6c Coagulation factor X Homo sapiens <0.1 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12690&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646156 46513139 ZINC14950425 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22845 CNCc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1ccc2onc(N)c2c1)C(F)(F)F InChI=1S/C28H23F3N6O2/c1-33-15-17-4-2-3-5-20(17)16-6-8-18(9-7-16)36-13-12-21-24(27(36)38)37(34-25(21)28(29,30)31)19-10-11-23-22(14-19)26(32)35-39-23/h2-11,14,33H,12-13,15H2,1H3,(H2,32,35) XTYJPQDODCELTO-UHFFFAOYSA-N 12691 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(methylamino)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 6d Coagulation factor X Homo sapiens 0.34 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12691&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646157 46513140 ZINC14950428 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22846 Nc1noc2ccc(cc12)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CCCC1)C(F)(F)F InChI=1S/C31H27F3N6O2/c32-31(33,34)28-24-13-16-39(30(41)27(24)40(36-28)22-11-12-26-25(17-22)29(35)37-42-26)21-9-7-19(8-10-21)23-6-2-1-5-20(23)18-38-14-3-4-15-38/h1-2,5-12,17H,3-4,13-16,18H2,(H2,35,37) SNBIFZWZJIQRJQ-UHFFFAOYSA-N 12692 1-(3-amino-1,2-benzoxazol-5-yl)-6-{4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 6e Coagulation factor X Homo sapiens 0.15 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12692&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086982 46513141 ZINC14950430 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22847 Nc1noc2ccc(cc12)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)C(F)(F)F InChI=1S/C31H27F3N6O3/c32-31(33,34)28-24-12-14-39(30(42)27(24)40(36-28)21-9-10-26-25(15-21)29(35)37-43-26)20-7-5-18(6-8-20)23-4-2-1-3-19(23)16-38-13-11-22(41)17-38/h1-10,15,22,41H,11-14,16-17H2,(H2,35,37)/t22-/m1/s1 DFRIQJHMGZBFOM-JOCHJYFZSA-N 12693 1-(3-amino-1,2-benzoxazol-5-yl)-6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Coagulation factor X Homo sapiens 0.03 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12693&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 5QC 2FZZ 6914623 46513142 ZINC14210470 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22848 Nc1noc2ccc(cc12)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@H](O)C1)C(F)(F)F InChI=1S/C31H27F3N6O3/c32-31(33,34)28-24-12-14-39(30(42)27(24)40(36-28)21-9-10-26-25(15-21)29(35)37-43-26)20-7-5-18(6-8-20)23-4-2-1-3-19(23)16-38-13-11-22(41)17-38/h1-10,15,22,41H,11-14,16-17H2,(H2,35,37)/t22-/m0/s1 DFRIQJHMGZBFOM-QFIPXVFZSA-N 12694 1-(3-amino-1,2-benzoxazol-5-yl)-6-[4-(2-{[(3S)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 6g Coagulation factor X Homo sapiens 0.12 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12694&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646158 46513143 ZINC14950433 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22849 Nc1noc2ccc(cc12)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CCC(O)CC1)C(F)(F)F InChI=1S/C32H29F3N6O3/c33-32(34,35)29-25-13-16-40(31(43)28(25)41(37-29)22-9-10-27-26(17-22)30(36)38-44-27)21-7-5-19(6-8-21)24-4-2-1-3-20(24)18-39-14-11-23(42)12-15-39/h1-10,17,23,42H,11-16,18H2,(H2,36,38) KZFKAYHQURWCNL-UHFFFAOYSA-N 12695 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(4-hydroxypiperidin-1-yl)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 6h Coagulation factor X Homo sapiens 0.22 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12695&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646159 46513144 ZINC14950437 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22850 Nc1noc2ccc(cc12)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CCOCC1)C(F)(F)F InChI=1S/C31H27F3N6O3/c32-31(33,34)28-24-11-12-39(30(41)27(24)40(36-28)22-9-10-26-25(17-22)29(35)37-43-26)21-7-5-19(6-8-21)23-4-2-1-3-20(23)18-38-13-15-42-16-14-38/h1-10,17H,11-16,18H2,(H2,35,37) WLRAVKVAWRRKIZ-UHFFFAOYSA-N 12696 1-(3-amino-1,2-benzoxazol-5-yl)-6-{4-[2-(morpholin-4-ylmethyl)phenyl]phenyl}-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 6i Coagulation factor X Homo sapiens 0.35 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12696&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086981 46513145 ZINC14950441 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22851 Nc1noc2ccc(cc12)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CCNCC1)C(F)(F)F InChI=1S/C31H28F3N7O2/c32-31(33,34)28-24-11-14-40(30(42)27(24)41(37-28)22-9-10-26-25(17-22)29(35)38-43-26)21-7-5-19(6-8-21)23-4-2-1-3-20(23)18-39-15-12-36-13-16-39/h1-10,17,36H,11-16,18H2,(H2,35,38) KZAQAXHOSKDNPX-UHFFFAOYSA-N 12697 1-(3-amino-1,2-benzoxazol-5-yl)-6-{4-[2-(piperazin-1-ylmethyl)phenyl]phenyl}-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 6j Coagulation factor X Homo sapiens 0.64 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12697&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646160 46513146 ZINC23358135 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22852 CN1CCN(Cc2ccccc2-c2ccc(cc2)N2CCc3c(nn(c3C2=O)-c2ccc3onc(N)c3c2)C(F)(F)F)CC1 InChI=1S/C32H30F3N7O2/c1-39-14-16-40(17-15-39)19-21-4-2-3-5-24(21)20-6-8-22(9-7-20)41-13-12-25-28(31(41)43)42(37-29(25)32(33,34)35)23-10-11-27-26(18-23)30(36)38-44-27/h2-11,18H,12-17,19H2,1H3,(H2,36,38) ASRYKRVWPDUVJA-UHFFFAOYSA-N 12698 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(4-methylpiperazin-1-yl)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 6k Coagulation factor X Homo sapiens 0.71 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12698&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646161 46513147 ZINC23358138 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22853 Nc1noc2ccc(cc12)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1F)-c1ccccc1CN1CCCC1)C(F)(F)F InChI=1S/C31H26F4N6O2/c32-24-15-18(21-6-2-1-5-19(21)17-39-12-3-4-13-39)7-9-25(24)40-14-11-22-27(30(40)42)41(37-28(22)31(33,34)35)20-8-10-26-23(16-20)29(36)38-43-26/h1-2,5-10,15-16H,3-4,11-14,17H2,(H2,36,38) KVMNDDXISQYKQH-UHFFFAOYSA-N 12699 1-(3-amino-1,2-benzoxazol-5-yl)-6-{2-fluoro-4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 7b Coagulation factor X Homo sapiens 0.24 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12699&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646162 46513148 ZINC14950454 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22854 Nc1noc2ccc(cc12)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1F)-c1ccccc1CN1CC[C@@H](O)C1)C(F)(F)F InChI=1S/C31H26F4N6O3/c32-24-13-17(21-4-2-1-3-18(21)15-39-11-9-20(42)16-39)5-7-25(24)40-12-10-22-27(30(40)43)41(37-28(22)31(33,34)35)19-6-8-26-23(14-19)29(36)38-44-26/h1-8,13-14,20,42H,9-12,15-16H2,(H2,36,38)/t20-/m1/s1 BABFXZTUINNAIF-HXUWFJFHSA-N 12700 1-(3-amino-1,2-benzoxazol-5-yl)-6-[2-fluoro-4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 7c Coagulation factor X Homo sapiens 0.16 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12700&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646163 46513149 ZINC03979347 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22855 CN(C)Cc1ccccc1-c1ccc(cc1)N1CCc2c(C)nn(c2C1=O)-c1ccc2onc(N)c2c1 InChI=1S/C29H28N6O2/c1-18-23-14-15-34(21-10-8-19(9-11-21)24-7-5-4-6-20(24)17-33(2)3)29(36)27(23)35(31-18)22-12-13-26-25(16-22)28(30)32-37-26/h4-13,16H,14-15,17H2,1-3H3,(H2,30,32) RQRUABSSKUUZEJ-UHFFFAOYSA-N 12701 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-3-methyl-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 12a Coagulation factor X Homo sapiens 0.55 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12701&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086973 46513150 ZINC03979346 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22856 Cc1nn(c2c1CCN(C2=O)c1ccc(cc1)-c1ccccc1CN1CCCC1)-c1ccc2onc(N)c2c1 InChI=1S/C31H30N6O2/c1-20-25-14-17-36(31(38)29(25)37(33-20)24-12-13-28-27(18-24)30(32)34-39-28)23-10-8-21(9-11-23)26-7-3-2-6-22(26)19-35-15-4-5-16-35/h2-3,6-13,18H,4-5,14-17,19H2,1H3,(H2,32,34) JVDKHRYLSLCTBR-UHFFFAOYSA-N 12702 1-(3-amino-1,2-benzoxazol-5-yl)-3-methyl-6-{4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 12b Coagulation factor X Homo sapiens 0.31 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12702&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086988 46513151 ZINC14950457 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22857 Cc1nn(c2c1CCN(C2=O)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)-c1ccc2onc(N)c2c1 InChI=1S/C31H30N6O3/c1-19-25-13-15-36(31(39)29(25)37(33-19)23-10-11-28-27(16-23)30(32)34-40-28)22-8-6-20(7-9-22)26-5-3-2-4-21(26)17-35-14-12-24(38)18-35/h2-11,16,24,38H,12-15,17-18H2,1H3,(H2,32,34)/t24-/m1/s1 BGSMHNHLTFKRFT-XMMPIXPASA-N 12703 1-(3-amino-1,2-benzoxazol-5-yl)-6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-3-methyl-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 12c Coagulation factor X Homo sapiens 0.27 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12703&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646164 46513152 ZINC14950461 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22858 Cc1nn(c2c1CCN(C2=O)c1ccc(cc1F)-c1ccccc1CN1CC[C@@H](O)C1)-c1ccc2onc(N)c2c1 InChI=1S/C31H29FN6O3/c1-18-23-11-13-37(31(40)29(23)38(34-18)21-7-9-28-25(15-21)30(33)35-41-28)27-8-6-19(14-26(27)32)24-5-3-2-4-20(24)16-36-12-10-22(39)17-36/h2-9,14-15,22,39H,10-13,16-17H2,1H3,(H2,33,35)/t22-/m1/s1 JNQXDDWCPSDRRR-JOCHJYFZSA-N 12704 1-(3-amino-1,2-benzoxazol-5-yl)-6-[2-fluoro-4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-3-methyl-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 12d Coagulation factor X Homo sapiens 0.34 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.02.069 10.7270/Q26T0JW1 16730984 aid1796935 Pinto, DJ; Orwat, MJ; Quan, ML; Han, Q; Galemmo, RA; Amparo, E; Wells, B; Ellis, C; He, MY; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; Mersinger, L; Kettner, C; Bai, S; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12704&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646165 46513153 ZINC14950465 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22859 CN(C)Cc1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C24H20F4N8O2/c1-34(2)12-21-30-7-8-35(21)13-3-5-17(16(25)10-13)31-23(37)18-11-20(24(26,27)28)32-36(18)14-4-6-19-15(9-14)22(29)33-38-19/h3-11H,12H2,1-2H3,(H2,29,33)(H,31,37) OFJRNBWSFXEHSA-UHFFFAOYSA-N 12676 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[2-fluoro-4-[(2-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::BMS-561389::CHEMBL206335::CHEMBL558198::DPC 906::Razaxaban Coagulation factor X Homo sapiens 0.19 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12676&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search IK8 1Z6E 204102 46513128 CHEMBL206335CHEMBL558198 ZINC03633839 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22860 COc1ccc(cc1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1S(C)(=O)=O)C(F)(F)F InChI=1S/C25H19F4N3O4S/c1-36-17-10-8-16(9-11-17)32-21(14-23(31-32)25(27,28)29)24(33)30-20-12-7-15(13-19(20)26)18-5-3-4-6-22(18)37(2,34)35/h3-14H,1-2H3,(H,30,33) VLCRCSZZKBAYJK-UHFFFAOYSA-N 12705 CHEMBL146793::N-[2-fluoro-4-(2-methanesulfonylphenyl)phenyl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::N-arylpyrazole carboxamide 3 Coagulation factor X Homo sapiens 3.5 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12705&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11330048 46513154 CHEMBL146793 ZINC14950470 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22861 COc1ccc(cc1)-n1nc(C#N)c(N)c1C(=O)Nc1ccc(cc1F)-c1ccccc1S(C)(=O)=O InChI=1S/C25H20FN5O4S/c1-35-17-10-8-16(9-11-17)31-24(23(28)21(14-27)30-31)25(32)29-20-12-7-15(13-19(20)26)18-5-3-4-6-22(18)36(2,33)34/h3-13H,28H2,1-2H3,(H,29,32) YEICLSYLHFPMDT-UHFFFAOYSA-N 12706 4-amino-3-cyano-N-[2-fluoro-4-(2-methanesulfonylphenyl)phenyl]-1-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide::N-arylpyrazole carboxamide 12 Coagulation factor X Homo sapiens 8.4 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12706&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646166 46513155 ZINC14950474 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22862 COc1ccc(cc1)-n1nc(C#N)c2[nH]c(=O)n(-c3ccc(cc3F)-c3ccccc3S(C)(=O)=O)c(=O)c12 InChI=1S/C26H18FN5O5S/c1-37-17-10-8-16(9-11-17)32-24-23(20(14-28)30-32)29-26(34)31(25(24)33)21-12-7-15(13-19(21)27)18-5-3-4-6-22(18)38(2,35)36/h3-13H,1-2H3,(H,29,34) MYCUIGIJETXUNP-UHFFFAOYSA-N 12707 6-[2-fluoro-4-(2-methanesulfonylphenyl)phenyl]-1-(4-methoxyphenyl)-5,7-dioxo-1H,4H,5H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carbonitrile::pyrazolo[4,3-d]pyrimidindione 13 Coagulation factor X Homo sapiens 3.0 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12707&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9893238 46513156 ZINC01490566 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22863 COC(=O)c1nn(-c2ccc(OC)cc2)c2c1ncn(-c1ccc(cc1)-c1ccccc1S(N)(=O)=O)c2=O InChI=1S/C26H21N5O6S/c1-36-19-13-11-18(12-14-19)31-24-22(23(29-31)26(33)37-2)28-15-30(25(24)32)17-9-7-16(8-10-17)20-5-3-4-6-21(20)38(27,34)35/h3-15H,1-2H3,(H2,27,34,35) UQOVWSRVOBGIEJ-UHFFFAOYSA-N 12708 methyl 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-sulfamoylphenyl)phenyl]-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxylate::pyrazolo[4,3-d]pyrimidinone 20 Coagulation factor X Homo sapiens 2.8 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12708&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9936861 46513157 ZINC14950479 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22864 COC(=O)c1nn(-c2ccc(OC)cc2)c2c1ncn(-c1ccc(cc1F)-c1ccccc1S(N)(=O)=O)c2=O InChI=1S/C26H20FN5O6S/c1-37-17-10-8-16(9-11-17)32-24-22(23(30-32)26(34)38-2)29-14-31(25(24)33)20-12-7-15(13-19(20)27)18-5-3-4-6-21(18)39(28,35)36/h3-14H,1-2H3,(H2,28,35,36) GVTXDWZDPBSUCW-UHFFFAOYSA-N 12709 methyl 6-[2-fluoro-4-(2-sulfamoylphenyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxylate::pyrazolo[4,3-d]pyrimidinone 21 Coagulation factor X Homo sapiens 1.8 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12709&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9850515 46513158 ZINC14950485 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22865 COc1ccc(cc1)-n1nc(C(N)=O)c2ncn(-c3ccc(cc3)-c3ccccc3S(N)(=O)=O)c(=O)c12 InChI=1S/C25H20N6O5S/c1-36-18-12-10-17(11-13-18)31-23-21(22(29-31)24(26)32)28-14-30(25(23)33)16-8-6-15(7-9-16)19-4-2-3-5-20(19)37(27,34)35/h2-14H,1H3,(H2,26,32)(H2,27,34,35) MCSJZAXCNUGUJU-UHFFFAOYSA-N 12710 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-sulfamoylphenyl)phenyl]-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxamide::pyrazolo[4,3-d]pyrimidinone 22 Coagulation factor X Homo sapiens 1.7 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12710&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9914510 46513159 ZINC14950489 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22866 COc1ccc(cc1)-n1nc(C(N)=O)c2ncn(-c3ccc(cc3F)-c3ccccc3S(N)(=O)=O)c(=O)c12 InChI=1S/C25H19FN6O5S/c1-37-16-9-7-15(8-10-16)32-23-21(22(30-32)24(27)33)29-13-31(25(23)34)19-11-6-14(12-18(19)26)17-4-2-3-5-20(17)38(28,35)36/h2-13H,1H3,(H2,27,33)(H2,28,35,36) FBSRGKJNKRNNHY-UHFFFAOYSA-N 12711 6-[2-fluoro-4-(2-sulfamoylphenyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxamide::pyrazolo[4,3-d]pyrimidinone 23 Coagulation factor X Homo sapiens 1.2 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12711&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9807142 46513160 ZINC14950493 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22867 COc1ccc(cc1)-n1nc(C#N)c2ncn(-c3ccc(cc3)-c3ccccc3S(N)(=O)=O)c(=O)c12 InChI=1S/C25H18N6O4S/c1-35-19-12-10-18(11-13-19)31-24-23(21(14-26)29-31)28-15-30(25(24)32)17-8-6-16(7-9-17)20-4-2-3-5-22(20)36(27,33)34/h2-13,15H,1H3,(H2,27,33,34) PZLTVVGYKMLOSY-UHFFFAOYSA-N 12712 2-{4-[3-cyano-1-(4-methoxyphenyl)-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-6-yl]phenyl}benzene-1-sulfonamide::pyrazolo[4,3-d]pyrimidinone 24 Coagulation factor X Homo sapiens 1.9 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12712&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9892098 46513161 ZINC14950497 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22868 COc1ccc(cc1)-n1nc(C(O)=O)c2ncn(-c3ccc(cc3)-c3ccccc3S(N)(=O)=O)c(=O)c12 InChI=1S/C25H19N5O6S/c1-36-18-12-10-17(11-13-18)30-23-21(22(28-30)25(32)33)27-14-29(24(23)31)16-8-6-15(7-9-16)19-4-2-3-5-20(19)37(26,34)35/h2-14H,1H3,(H,32,33)(H2,26,34,35) QDDZLGZKRAPRJX-UHFFFAOYSA-N 12713 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-sulfamoylphenyl)phenyl]-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid::pyrazolo[4,3-d]pyrimidinone 25 Coagulation factor X Homo sapiens 38 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12713&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9827921 46513162 ZINC14950500 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22869 COc1ccc(cc1)-n1nc(CN)c2ncn(-c3ccc(cc3)-c3ccccc3S(N)(=O)=O)c(=O)c12 InChI=1S/C25H22N6O4S/c1-35-19-12-10-18(11-13-19)31-24-23(21(14-26)29-31)28-15-30(25(24)32)17-8-6-16(7-9-17)20-4-2-3-5-22(20)36(27,33)34/h2-13,15H,14,26H2,1H3,(H2,27,33,34) VRIDMBGQPVACOS-UHFFFAOYSA-N 12714 2-{4-[3-(aminomethyl)-1-(4-methoxyphenyl)-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-6-yl]phenyl}benzene-1-sulfonamide::pyrazolo[4,3-d]pyrimidinone 26 Coagulation factor X Homo sapiens 22 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12714&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9873782 46513163 ZINC14950503 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22870 COc1ccc(cc1)-n1nc(c2c(C)nn(-c3ccc(cc3)-c3ccccc3S(N)(=O)=O)c(=O)c12)C(F)(F)F InChI=1S/C26H20F3N5O4S/c1-15-22-23(33(32-24(22)26(27,28)29)17-11-13-19(38-2)14-12-17)25(35)34(31-15)18-9-7-16(8-10-18)20-5-3-4-6-21(20)39(30,36)37/h3-14H,1-2H3,(H2,30,36,37) MWWMMKSYCBBFRB-UHFFFAOYSA-N 12715 2-{4-[1-(4-methoxyphenyl)-4-methyl-7-oxo-3-(trifluoromethyl)-1H,6H,7H-pyrazolo[3,4-d]pyridazin-6-yl]phenyl}benzene-1-sulfonamide::pyrazolo[3,4-d]pyridazinone 32 Coagulation factor X Homo sapiens 2.8 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12715&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086911 46513164 ZINC14950508 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22875 CCOC(=O)c1nn(-c2ccc(OC)cc2)c2c1ncn(-c1ccc(cc1)-c1ccccc1CN1CCCC1)c2=O InChI=1S/C32H31N5O4/c1-3-41-32(39)29-28-30(37(34-29)25-14-16-26(40-2)17-15-25)31(38)36(21-33-28)24-12-10-22(11-13-24)27-9-5-4-8-23(27)20-35-18-6-7-19-35/h4-5,8-17,21H,3,6-7,18-20H2,1-2H3 MQQBADQNPQFSSO-UHFFFAOYSA-N 12716 ethyl 1-(4-methoxyphenyl)-7-oxo-6-{4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxylate::pyrazolo[4,3-d]pyrimidinone 38a Coagulation factor X Homo sapiens 3.8 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12716&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20760223 46513165 ZINC14950514 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22876 CCOC(=O)c1nn(-c2ccc(OC)cc2)c2c1ncn(-c1ccc(cc1F)-c1ccccc1CN1CCCC1)c2=O InChI=1S/C32H30FN5O4/c1-3-42-32(40)29-28-30(38(35-29)23-11-13-24(41-2)14-12-23)31(39)37(20-34-28)27-15-10-21(18-26(27)33)25-9-5-4-8-22(25)19-36-16-6-7-17-36/h4-5,8-15,18,20H,3,6-7,16-17,19H2,1-2H3 VBAWFAPJSYXGPR-UHFFFAOYSA-N 12717 ethyl 6-{2-fluoro-4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxylate::pyrazolo[4,3-d]pyrimidinone 38b Coagulation factor X Homo sapiens 3.6 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12717&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20760219 46513166 ZINC14950518 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22877 CCOC(=O)c1nn(-c2ccc(OC)cc2)c2c1ncn(-c1ccc(cc1)-c1ccccc1CO)c2=O InChI=1S/C28H24N4O5/c1-3-37-28(35)25-24-26(32(30-25)21-12-14-22(36-2)15-13-21)27(34)31(17-29-24)20-10-8-18(9-11-20)23-7-5-4-6-19(23)16-33/h4-15,17,33H,3,16H2,1-2H3 ASJJORPROMYORU-UHFFFAOYSA-N 12718 ethyl 6-{4-[2-(hydroxymethyl)phenyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxylate::pyrazolo[4,3-d]pyrimidinone 38c Coagulation factor X Homo sapiens 45 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12718&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646167 46513167 ZINC14950522 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22878 COc1ccc(cc1)-n1nc(C(N)=O)c2ncn(-c3ccc(cc3)-c3ccccc3CN3CCCC3)c(=O)c12 InChI=1S/C30H28N6O3/c1-39-24-14-12-23(13-15-24)36-28-26(27(33-36)29(31)37)32-19-35(30(28)38)22-10-8-20(9-11-22)25-7-3-2-6-21(25)18-34-16-4-5-17-34/h2-3,6-15,19H,4-5,16-18H2,1H3,(H2,31,37) YJVFQVDWQUJXRE-UHFFFAOYSA-N 12719 1-(4-methoxyphenyl)-7-oxo-6-{4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxamide::pyrazolo[4,3-d]pyrimidinone 39a Coagulation factor X Homo sapiens 1.1 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12719&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9809479 46513168 ZINC13982566 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22879 COc1ccc(cc1)-n1nc(C(N)=O)c2ncn(-c3ccc(cc3F)-c3ccccc3CN3CCCC3)c(=O)c12 InChI=1S/C30H27FN6O3/c1-40-22-11-9-21(10-12-22)37-28-26(27(34-37)29(32)38)33-18-36(30(28)39)25-13-8-19(16-24(25)31)23-7-3-2-6-20(23)17-35-14-4-5-15-35/h2-3,6-13,16,18H,4-5,14-15,17H2,1H3,(H2,32,38) YNAITOPHNFDVOT-UHFFFAOYSA-N 12720 6-{2-fluoro-4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxamide::pyrazolo[4,3-d]pyrimidinone 39b Coagulation factor X Homo sapiens 0.74 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12720&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20760195 46513169 ZINC14950526 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22880 COc1ccc(cc1)-n1nc(C(N)=O)c2ncn(-c3ccc(cc3)-c3ccccc3CN3CC[C@@H](O)C3)c(=O)c12 InChI=1S/C30H28N6O4/c1-40-24-12-10-22(11-13-24)36-28-26(27(33-36)29(31)38)32-18-35(30(28)39)21-8-6-19(7-9-21)25-5-3-2-4-20(25)16-34-15-14-23(37)17-34/h2-13,18,23,37H,14-17H2,1H3,(H2,31,38)/t23-/m1/s1 BCRNYPLFVPQVNH-HSZRJFAPSA-N 12721 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxamide::pyrazolo[4,3-d]pyrimidinone 39c Coagulation factor X Homo sapiens 1.5 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12721&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646168 46513170 ZINC14950529 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22881 COc1ccc(cc1)-n1nc(C#N)c2ncn(-c3ccc(cc3)-c3ccccc3CN3CCCC3)c(=O)c12 InChI=1S/C30H26N6O2/c1-38-25-14-12-24(13-15-25)36-29-28(27(18-31)33-36)32-20-35(30(29)37)23-10-8-21(9-11-23)26-7-3-2-6-22(26)19-34-16-4-5-17-34/h2-3,6-15,20H,4-5,16-17,19H2,1H3 CTNVRGOKCPAVEY-UHFFFAOYSA-N 12722 1-(4-methoxyphenyl)-7-oxo-6-{4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carbonitrile::pyrazolo[4,3-d]pyrimidinone 40a Coagulation factor X Homo sapiens 1.7 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12722&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9938917 46513171 ZINC14950534 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22882 COc1ccc(cc1)-n1nc(C#N)c2ncn(-c3ccc(cc3)-c3ccccc3CN(C)C)c(=O)c12 InChI=1S/C28H24N6O2/c1-32(2)17-20-6-4-5-7-24(20)19-8-10-21(11-9-19)33-18-30-26-25(16-29)31-34(27(26)28(33)35)22-12-14-23(36-3)15-13-22/h4-15,18H,17H2,1-3H3 OQYKUOCGCZXLBD-UHFFFAOYSA-N 12723 6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carbonitrile::pyrazolo[4,3-d]pyrimidinone 40b Coagulation factor X Homo sapiens 2.1 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12723&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646169 46513172 ZINC14950538 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22883 COc1ccc(cc1)-n1nc(C#N)c2nc(C)n(-c3ccc(cc3)-c3ccccc3CN(C)C)c(=O)c12 InChI=1S/C29H26N6O2/c1-19-31-27-26(17-30)32-35(23-13-15-24(37-4)16-14-23)28(27)29(36)34(19)22-11-9-20(10-12-22)25-8-6-5-7-21(25)18-33(2)3/h5-16H,18H2,1-4H3 WPDOZNXOLFQHAY-UHFFFAOYSA-N 12724 6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-1-(4-methoxyphenyl)-5-methyl-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carbonitrile::pyrazolo[4,3-d]pyrimidinone 40c Coagulation factor X Homo sapiens 1.8 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12724&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646170 46513173 ZINC14950541 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22884 COc1ccc(cc1)-n1nc(Cn2ccnc2)c2nc(C)n(-c3ccc(cc3)-c3ccccc3CN3CCCC3)c(=O)c12 InChI=1S/C34H33N7O2/c1-24-36-32-31(22-39-20-17-35-23-39)37-41(28-13-15-29(43-2)16-14-28)33(32)34(42)40(24)27-11-9-25(10-12-27)30-8-4-3-7-26(30)21-38-18-5-6-19-38/h3-4,7-17,20,23H,5-6,18-19,21-22H2,1-2H3 VPVYKOHZRXOPHE-UHFFFAOYSA-N 12725 3-(1H-imidazol-1-ylmethyl)-1-(4-methoxyphenyl)-5-methyl-6-{4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::pyrazolo[4,3-d]pyrimidinone 43a Coagulation factor X Homo sapiens 2.1 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12725&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22087014 46513174 ZINC14950545 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22885 COc1ccc(cc1)-n1nc(Cn2cnnn2)c2nc(C)n(-c3ccc(cc3)-c3ccccc3CN3CCCC3)c(=O)c12 InChI=1S/C32H31N9O2/c1-22-34-30-29(20-39-21-33-36-37-39)35-41(26-13-15-27(43-2)16-14-26)31(30)32(42)40(22)25-11-9-23(10-12-25)28-8-4-3-7-24(28)19-38-17-5-6-18-38/h3-4,7-16,21H,5-6,17-20H2,1-2H3 PMSXNNAQNLQNNB-UHFFFAOYSA-N 12726 1-(4-methoxyphenyl)-5-methyl-6-{4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-3-(1H-1,2,3,4-tetrazol-1-ylmethyl)-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::pyrazolo[4,3-d]pyrimidinone 43b Coagulation factor X Homo sapiens 1.4 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12726&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086991 46513175 ZINC14950549 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22886 COc1ccc(cc1)-n1nc(Cn2ncnn2)c2nc(C)n(-c3ccc(cc3)-c3ccccc3CN3CCCC3)c(=O)c12 InChI=1S/C32H31N9O2/c1-22-35-30-29(20-39-34-21-33-37-39)36-41(26-13-15-27(43-2)16-14-26)31(30)32(42)40(22)25-11-9-23(10-12-25)28-8-4-3-7-24(28)19-38-17-5-6-18-38/h3-4,7-16,21H,5-6,17-20H2,1-2H3 UURBPAIVFZTTDM-UHFFFAOYSA-N 12727 1-(4-methoxyphenyl)-5-methyl-6-{4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-3-(2H-1,2,3,4-tetrazol-2-ylmethyl)-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::pyrazolo[4,3-d]pyrimidinone 43c Coagulation factor X Homo sapiens 1.9 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12727&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086992 46513176 ZINC03842918 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22887 COc1ccc(cc1)-n1nc(c2c(C)nn(-c3ccc(cc3)-c3ccccc3CN3CCCC3)c(=O)c12)C(F)(F)F InChI=1S/C31H28F3N5O2/c1-20-27-28(38(36-29(27)31(32,33)34)23-13-15-25(41-2)16-14-23)30(40)39(35-20)24-11-9-21(10-12-24)26-8-4-3-7-22(26)19-37-17-5-6-18-37/h3-4,7-16H,5-6,17-19H2,1-2H3 QEXUYNKXWDDROG-UHFFFAOYSA-N 12728 1-(4-methoxyphenyl)-4-methyl-6-{4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-3-(trifluoromethyl)-1H,6H,7H-pyrazolo[3,4-d]pyridazin-7-one::pyrazolo[3,4-d]pyridazinone 46 Coagulation factor X Homo sapiens 2.8 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.04.044 10.7270/Q2319T41 16682200 aid1796936 Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12728&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086990 46513177 ZINC14950553 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22900 CN(C)Cc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1ccc2onc(N)c2c1)C(F)(F)F InChI=1S/C29H25F3N6O2/c1-36(2)16-18-5-3-4-6-21(18)17-7-9-19(10-8-17)37-14-13-22-25(28(37)39)38(34-26(22)29(30,31)32)20-11-12-24-23(15-20)27(33)35-40-24/h3-12,15H,13-14,16H2,1-2H3,(H2,33,35) GJINLTTVIZRYJU-UHFFFAOYSA-N 12681 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Analogue 6a::bicyclic pyrazole scaffold::dihydropyrazolopyridinone analogue 9 Coagulation factor X Homo sapiens 0.04 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12681&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086976 46513130 ZINC14950399 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22901 CN(C)Cc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1ccccc1S(N)(=O)=O)C(F)(F)F InChI=1S/C28H26F3N5O3S/c1-34(2)17-19-7-3-4-8-21(19)18-11-13-20(14-12-18)35-16-15-22-25(27(35)37)36(33-26(22)28(29,30)31)23-9-5-6-10-24(23)40(32,38)39/h3-14H,15-17H2,1-2H3,(H2,32,38,39) OLZJCKKKGQHZIC-UHFFFAOYSA-N 12730 2-[6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-1-yl]benzene-1-sulfonamide::dihydropyrazolopyridinone analogue 6a Coagulation factor X Homo sapiens 0.82 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12730&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646171 46513178 ZINC14950557 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22902 CN(C)Cc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1ccccc1C(N)=O)C(F)(F)F InChI=1S/C29H26F3N5O2/c1-35(2)17-19-7-3-4-8-21(19)18-11-13-20(14-12-18)36-16-15-23-25(28(36)39)37(34-26(23)29(30,31)32)24-10-6-5-9-22(24)27(33)38/h3-14H,15-17H2,1-2H3,(H2,33,38) RJQUBMYSUXLFOG-UHFFFAOYSA-N 12731 2-[6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-1-yl]benzamide::dihydropyrazolopyridinone analogue 6b Coagulation factor X Homo sapiens 2.70 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12731&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646172 46513179 ZINC14950561 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22903 CN(C)Cc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1cccc(c1)C#N)C(F)(F)F InChI=1S/C29H24F3N5O/c1-35(2)18-21-7-3-4-9-24(21)20-10-12-22(13-11-20)36-15-14-25-26(28(36)38)37(34-27(25)29(30,31)32)23-8-5-6-19(16-23)17-33/h3-13,16H,14-15,18H2,1-2H3 IFRCSPDVZWWAFL-UHFFFAOYSA-N 12732 3-[6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-1-yl]benzonitrile::dihydropyrazolopyridinone analogue 6c Coagulation factor X Homo sapiens 12 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12732&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646173 46513180 ZINC14950565 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22904 CN(C)Cc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1cccc(c1)C(N)=O)C(F)(F)F InChI=1S/C29H26F3N5O2/c1-35(2)17-20-6-3-4-9-23(20)18-10-12-21(13-11-18)36-15-14-24-25(28(36)39)37(34-26(24)29(30,31)32)22-8-5-7-19(16-22)27(33)38/h3-13,16H,14-15,17H2,1-2H3,(H2,33,38) PKGPGSWPKRHPKB-UHFFFAOYSA-N 12733 3-[6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-1-yl]benzamide::dihydropyrazolopyridinone analogue 6d Coagulation factor X Homo sapiens 0.18 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12733&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 4QC 2G00 9549214 46513181 ZINC14950570 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22905 CN(C)Cc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1cccc(c1)[N+]([O-])=O)C(F)(F)F InChI=1S/C28H24F3N5O3/c1-33(2)17-19-6-3-4-9-23(19)18-10-12-20(13-11-18)34-15-14-24-25(27(34)37)35(32-26(24)28(29,30)31)21-7-5-8-22(16-21)36(38)39/h3-13,16H,14-15,17H2,1-2H3 OMIOARBFYCUIPP-UHFFFAOYSA-N 12734 6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-1-(3-nitrophenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::dihydropyrazolopyridinone analogue 6e Coagulation factor X Homo sapiens 20.0 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12734&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646174 46513182 ZINC14950573 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22906 CN(C)Cc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1cccc(N)c1)C(F)(F)F InChI=1S/C28H26F3N5O/c1-34(2)17-19-6-3-4-9-23(19)18-10-12-21(13-11-18)35-15-14-24-25(27(35)37)36(33-26(24)28(29,30)31)22-8-5-7-20(32)16-22/h3-13,16H,14-15,17,32H2,1-2H3 VEQXNYMNICHOPH-UHFFFAOYSA-N 12735 1-(3-aminophenyl)-6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::dihydropyrazolopyridinone analogue 6f Coagulation factor X Homo sapiens 2.00 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12735&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646175 46513183 ZINC14950577 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22907 CN(C)Cc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1cccc(NC(C)=O)c1)C(F)(F)F InChI=1S/C30H28F3N5O2/c1-19(39)34-22-8-6-9-24(17-22)38-27-26(28(35-38)30(31,32)33)15-16-37(29(27)40)23-13-11-20(12-14-23)25-10-5-4-7-21(25)18-36(2)3/h4-14,17H,15-16,18H2,1-3H3,(H,34,39) LSNYUMCSNUIESQ-UHFFFAOYSA-N 12736 N-{3-[6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-1-yl]phenyl}acetamide::dihydropyrazolopyridinone analogue 6g Coagulation factor X Homo sapiens 88 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12736&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646176 46513184 ZINC14950580 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22908 CN(C)Cc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1cccc(NC(N)=O)c1)C(F)(F)F InChI=1S/C29H27F3N6O2/c1-36(2)17-19-6-3-4-9-23(19)18-10-12-21(13-11-18)37-15-14-24-25(27(37)39)38(35-26(24)29(30,31)32)22-8-5-7-20(16-22)34-28(33)40/h3-13,16H,14-15,17H2,1-2H3,(H3,33,34,40) SAJQZUNUQXWXKF-UHFFFAOYSA-N 12737 dihydropyrazolopyridinone analogue 6h::{3-[6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-1-yl]phenyl}urea Coagulation factor X Homo sapiens 54 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12737&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646177 46513185 ZINC14950584 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22909 CN(C)Cc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1cccc(NS(C)(=O)=O)c1)C(F)(F)F InChI=1S/C29H28F3N5O3S/c1-35(2)18-20-7-4-5-10-24(20)19-11-13-22(14-12-19)36-16-15-25-26(28(36)38)37(33-27(25)29(30,31)32)23-9-6-8-21(17-23)34-41(3,39)40/h4-14,17,34H,15-16,18H2,1-3H3 KSINTWWJWBSRMR-UHFFFAOYSA-N 12738 N-{3-[6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-1-yl]phenyl}methanesulfonamide::dihydropyrazolopyridinone analogue 6i Coagulation factor X Homo sapiens 47 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12738&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646178 46513186 ZINC14950587 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22910 CCc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN(C)C)C(F)(F)F InChI=1S/C30H29F3N4O/c1-4-20-9-13-24(14-10-20)37-27-26(28(34-37)30(31,32)33)17-18-36(29(27)38)23-15-11-21(12-16-23)25-8-6-5-7-22(25)19-35(2)3/h5-16H,4,17-19H2,1-3H3 JMGINPKJPSJGBU-UHFFFAOYSA-N 12739 6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-1-(4-ethylphenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::dihydropyrazolopyridinone analogue 6j Coagulation factor X Homo sapiens 2.6 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12739&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646179 46513187 ZINC14950590 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22911 COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN(C)C)C(F)(F)F InChI=1S/C29H27F3N4O2/c1-34(2)18-20-6-4-5-7-24(20)19-8-10-21(11-9-19)35-17-16-25-26(28(35)37)36(33-27(25)29(30,31)32)22-12-14-23(38-3)15-13-22/h4-15H,16-18H2,1-3H3 PCNAVRSNEWRPLH-UHFFFAOYSA-N 12740 6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::CHEMBL218525::dihydropyrazolopyridinone analogue 6k Coagulation factor X Homo sapiens 0.35 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12740&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10208201 46513188 CHEMBL218525 ZINC14950593 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22912 NS(=O)(=O)c1ccccc1-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)C(F)(F)F InChI=1S/C30H28F3N5O4S/c31-30(32,33)28-24-14-16-37(29(40)27(24)38(35-28)25-7-3-4-8-26(25)43(34,41)42)21-11-9-19(10-12-21)23-6-2-1-5-20(23)17-36-15-13-22(39)18-36/h1-12,22,39H,13-18H2,(H2,34,41,42)/t22-/m1/s1 SJYTVKFZNAQXEJ-JOCHJYFZSA-N 12741 2-{6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-1-yl}benzene-1-sulfonamide::dihydropyrazolopyridinone analogue 7a Coagulation factor X Homo sapiens 1.2 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12741&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646180 46513189 ZINC14950597 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22913 NC(=O)c1cccc(c1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)C(F)(F)F InChI=1S/C31H28F3N5O3/c32-31(33,34)28-26-13-15-38(30(42)27(26)39(36-28)23-6-3-5-20(16-23)29(35)41)22-10-8-19(9-11-22)25-7-2-1-4-21(25)17-37-14-12-24(40)18-37/h1-11,16,24,40H,12-15,17-18H2,(H2,35,41)/t24-/m1/s1 HNCKZXDJGXSLKW-XMMPIXPASA-N 12742 3-{6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-1-yl}benzamide::dihydropyrazolopyridinone analogue 7b Coagulation factor X Homo sapiens 0.72 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12742&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 12988920 46513190 ZINC14950601 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22914 COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)C(F)(F)F InChI=1S/C31H29F3N4O3/c1-41-25-12-10-23(11-13-25)38-28-27(29(35-38)31(32,33)34)15-17-37(30(28)40)22-8-6-20(7-9-22)26-5-3-2-4-21(26)18-36-16-14-24(39)19-36/h2-13,24,39H,14-19H2,1H3/t24-/m1/s1 BPIUYWHULQJMGZ-XMMPIXPASA-N 12743 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::CHEMBL221296::dihydropyrazolopyridinone analogue 7c Coagulation factor X Homo sapiens 0.76 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12743&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646181 46513191 CHEMBL221296 ZINC14950606 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22915 CS(=O)(=O)c1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1ccccc1S(N)(=O)=O)C(F)(F)F InChI=1S/C26H21F3N4O5S2/c1-39(35,36)21-8-4-2-6-18(21)16-10-12-17(13-11-16)32-15-14-19-23(25(32)34)33(31-24(19)26(27,28)29)20-7-3-5-9-22(20)40(30,37)38/h2-13H,14-15H2,1H3,(H2,30,37,38) VOJVOHLWWXOWOA-UHFFFAOYSA-N 12744 2-{6-[4-(2-methanesulfonylphenyl)phenyl]-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-1-yl}benzene-1-sulfonamide::dihydropyrazolopyridinone analogue 8a Coagulation factor X Homo sapiens 0.74 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12744&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646182 46513192 ZINC14950610 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22916 CS(=O)(=O)c1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1ccccc1C(N)=O)C(F)(F)F InChI=1S/C27H21F3N4O4S/c1-39(37,38)22-9-5-3-6-18(22)16-10-12-17(13-11-16)33-15-14-20-23(26(33)36)34(32-24(20)27(28,29)30)21-8-4-2-7-19(21)25(31)35/h2-13H,14-15H2,1H3,(H2,31,35) QLWWMHXUPONILX-UHFFFAOYSA-N 12745 2-{6-[4-(2-methanesulfonylphenyl)phenyl]-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-1-yl}benzamide::dihydropyrazolopyridinone analogue 8b Coagulation factor X Homo sapiens 2.0 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12745&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646183 46513193 ZINC14950614 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22917 COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1S(C)(=O)=O)C(F)(F)F InChI=1S/C27H22F3N3O4S/c1-37-20-13-11-19(12-14-20)33-24-22(25(31-33)27(28,29)30)15-16-32(26(24)34)18-9-7-17(8-10-18)21-5-3-4-6-23(21)38(2,35)36/h3-14H,15-16H2,1-2H3 STFFBDBZIZWAQU-UHFFFAOYSA-N 12746 6-[4-(2-methanesulfonylphenyl)phenyl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::dihydropyrazolopyridinone analogue 8c Coagulation factor X Homo sapiens 0.18 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12746&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646184 46513194 ZINC14950617 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22918 COc1ccc(c(c1)C(N)=O)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1S(C)(=O)=O)C(F)(F)F InChI=1S/C28H23F3N4O5S/c1-40-18-11-12-22(21(15-18)26(32)36)35-24-20(25(33-35)28(29,30)31)13-14-34(27(24)37)17-9-7-16(8-10-17)19-5-3-4-6-23(19)41(2,38)39/h3-12,15H,13-14H2,1-2H3,(H2,32,36) JXDVPMIGKXIRMQ-UHFFFAOYSA-N 12747 2-{6-[4-(2-methanesulfonylphenyl)phenyl]-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-1-yl}-5-methoxybenzamide::dihydropyrazolopyridinone analogue 8d Coagulation factor X Homo sapiens 0.18 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12747&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646185 46513195 ZINC14950621 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22919 COc1ccc(c(c1)S(N)(=O)=O)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1S(C)(=O)=O)C(F)(F)F InChI=1S/C27H23F3N4O6S2/c1-40-18-11-12-21(23(15-18)42(31,38)39)34-24-20(25(32-34)27(28,29)30)13-14-33(26(24)35)17-9-7-16(8-10-17)19-5-3-4-6-22(19)41(2,36)37/h3-12,15H,13-14H2,1-2H3,(H2,31,38,39) XZGQFOLYJWIPPP-UHFFFAOYSA-N 12748 2-{6-[4-(2-methanesulfonylphenyl)phenyl]-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-1-yl}-5-methoxybenzene-1-sulfonamide::dihydropyrazolopyridinone analogue 8e Coagulation factor X Homo sapiens 0.12 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12748&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646186 46513196 ZINC14950627 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22920 COc1ccc(c(N)c1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1S(C)(=O)=O)C(F)(F)F InChI=1S/C27H23F3N4O4S/c1-38-18-11-12-22(21(31)15-18)34-24-20(25(32-34)27(28,29)30)13-14-33(26(24)35)17-9-7-16(8-10-17)19-5-3-4-6-23(19)39(2,36)37/h3-12,15H,13-14,31H2,1-2H3 TXUBVGAAKIESEX-UHFFFAOYSA-N 12749 1-(2-amino-4-methoxyphenyl)-6-[4-(2-methanesulfonylphenyl)phenyl]-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::dihydropyrazolopyridinone analogue 8f Coagulation factor X Homo sapiens 0.2 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12749&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646187 46513197 ZINC14950631 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22921 Nc1noc2ccc(cc12)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)C(F)(F)F InChI=1S/C31H27F3N6O3/c32-31(33,34)28-24-12-14-39(30(42)27(24)40(36-28)21-9-10-26-25(15-21)29(35)37-43-26)20-7-5-18(6-8-20)23-4-2-1-3-19(23)16-38-13-11-22(41)17-38/h1-10,15,22,41H,11-14,16-17H2,(H2,35,37)/t22-/m1/s1 DFRIQJHMGZBFOM-JOCHJYFZSA-N 12693 1-(3-amino-1,2-benzoxazol-5-yl)-6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::BMS-740808 Coagulation factor X Homo sapiens 0.03 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.027 10.7270/Q2Z899NQ 16963264 aid1796939 Pinto, DJ; Galemmo, RA; Quan, ML; Orwat, MJ; Clark, C; Li, R; Wells, B; Woerner, F; Alexander, RS; Rossi, KA; Smallwood, A; Wong, PC; Luettgen, JM; Rendina, AR; Knabb, RM; He, K; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12693&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 5QC 2FZZ 6914623 46513142 ZINC14210470 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22922 Cc1cc(C(=O)Nc2ccc(cc2)-n2cnc3ccccc23)n(n1)-c1cccc(c1)C(N)=N InChI=1S/C25H21N7O/c1-16-13-23(32(30-16)20-6-4-5-17(14-20)24(26)27)25(33)29-18-9-11-19(12-10-18)31-15-28-21-7-2-3-8-22(21)31/h2-15H,1H3,(H3,26,27)(H,29,33) LADLMCQOCHQFDT-UHFFFAOYSA-N 12750 N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-1-(3-carbamimidoylphenyl)-3-methyl-1H-pyrazole-5-carboxamide::pyrazole analog 1 Coagulation factor X Homo sapiens 0.38 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12750&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23644671 46509405 ZINC14950636 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22923 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cccc(c1)C(N)=N InChI=1S/C24H22N6O3S/c1-15-13-21(30(29-15)19-6-4-5-17(14-19)23(25)26)24(31)28-18-11-9-16(10-12-18)20-7-2-3-8-22(20)34(27,32)33/h2-14H,1H3,(H3,25,26)(H,28,31)(H2,27,32,33) APFKCRTWNKCURW-UHFFFAOYSA-N 12751 1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::CHEMBL152854::CHEMBL37251::SN-429 Coagulation factor X Homo sapiens 0.013 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12751&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9869498 46513198 CHEMBL37251CHEMBL152854 ZINC02006270 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22924 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1)-n1cnc2ccccc12)C(F)(F)F InChI=1S/C25H18F3N7O/c26-25(27,28)22-13-21(35(33-22)18-5-3-4-15(12-18)23(29)30)24(36)32-16-8-10-17(11-9-16)34-14-31-19-6-1-2-7-20(19)34/h1-14H,(H3,29,30)(H,32,36) NTLLPLUWZPVXAP-UHFFFAOYSA-N 12752 N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-1-(3-carbamimidoylphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3a Coagulation factor X Homo sapiens 0.094 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12752&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646188 46513199 ZINC14950640 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22925 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1cnc2ccccc12)C(F)(F)F InChI=1S/C25H17F4N7O/c26-17-11-15(35-13-32-19-6-1-2-7-20(19)35)8-9-18(17)33-24(37)21-12-22(25(27,28)29)34-36(21)16-5-3-4-14(10-16)23(30)31/h1-13H,(H3,30,31)(H,33,37) TWBHVKYRNOGUJS-UHFFFAOYSA-N 12753 N-[4-(1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-1-(3-carbamimidoylphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3b Coagulation factor X Homo sapiens 0.1 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12753&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 187 1X7A 5287439 46513200 ZINC14950644 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22926 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1cnc2ncccc12)C(F)(F)F InChI=1S/C24H16F4N8O/c25-16-10-14(35-12-32-22-18(35)5-2-8-31-22)6-7-17(16)33-23(37)19-11-20(24(26,27)28)34-36(19)15-4-1-3-13(9-15)21(29)30/h1-12H,(H3,29,30)(H,33,37) GJMQGXYHAINXFV-UHFFFAOYSA-N 12754 1-(3-carbamimidoylphenyl)-N-(2-fluoro-4-{1H-imidazo[4,5-b]pyridin-1-yl}phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3c Coagulation factor X Homo sapiens 0.024 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12754&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646189 46513201 ZINC14950648 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22927 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1cnc2cnccc12)C(F)(F)F InChI=1S/C24H16F4N8O/c25-16-9-14(35-12-32-18-11-31-7-6-19(18)35)4-5-17(16)33-23(37)20-10-21(24(26,27)28)34-36(20)15-3-1-2-13(8-15)22(29)30/h1-12H,(H3,29,30)(H,33,37) PFHPACZGCWBXSL-UHFFFAOYSA-N 12755 1-(3-carbamimidoylphenyl)-N-(2-fluoro-4-{1H-imidazo[4,5-c]pyridin-1-yl}phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3d Coagulation factor X Homo sapiens 0.036 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12755&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646190 46513202 ZINC14950652 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22928 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1cnc2ccncc12)C(F)(F)F InChI=1S/C24H16F4N8O/c25-16-9-14(35-12-32-18-6-7-31-11-20(18)35)4-5-17(16)33-23(37)19-10-21(24(26,27)28)34-36(19)15-3-1-2-13(8-15)22(29)30/h1-12H,(H3,29,30)(H,33,37) OIMVSHQLQYINLD-UHFFFAOYSA-N 12756 1-(3-carbamimidoylphenyl)-N-(2-fluoro-4-{3H-imidazo[4,5-c]pyridin-3-yl}phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3e Coagulation factor X Homo sapiens 0.044 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12756&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646191 46513203 ZINC14950656 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22929 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1cnc2cccnc12)C(F)(F)F InChI=1S/C24H16F4N8O/c25-16-10-14(35-12-32-18-5-2-8-31-22(18)35)6-7-17(16)33-23(37)19-11-20(24(26,27)28)34-36(19)15-4-1-3-13(9-15)21(29)30/h1-12H,(H3,29,30)(H,33,37) DIPIGKJYPIWQRI-UHFFFAOYSA-N 12757 1-(3-carbamimidoylphenyl)-N-(2-fluoro-4-{3H-imidazo[4,5-b]pyridin-3-yl}phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3f Coagulation factor X Homo sapiens 0.028 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12757&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646192 46513204 ZINC14950660 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22930 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1cnc2cc(Cl)ccc12)C(F)(F)F InChI=1S/C25H16ClF4N7O/c26-14-4-7-20-19(9-14)33-12-36(20)15-5-6-18(17(27)10-15)34-24(38)21-11-22(25(28,29)30)35-37(21)16-3-1-2-13(8-16)23(31)32/h1-12H,(H3,31,32)(H,34,38) MQHMGLMHMVFZSM-UHFFFAOYSA-N 12758 1-(3-carbamimidoylphenyl)-N-[4-(5-chloro-1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3g Coagulation factor X Homo sapiens 0.42 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12758&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646193 46513205 ZINC14950662 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22931 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1cnc2ccc(Cl)cc12)C(F)(F)F InChI=1S/C25H16ClF4N7O/c26-14-4-6-19-20(9-14)36(12-33-19)15-5-7-18(17(27)10-15)34-24(38)21-11-22(25(28,29)30)35-37(21)16-3-1-2-13(8-16)23(31)32/h1-12H,(H3,31,32)(H,34,38) LSIQRMHAHHGORM-UHFFFAOYSA-N 12759 1-(3-carbamimidoylphenyl)-N-[4-(6-chloro-1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3h Coagulation factor X Homo sapiens 0.25 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12759&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646194 46513206 ZINC14950666 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22932 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1cnc2cc(ccc12)C(F)(F)F)C(F)(F)F InChI=1S/C26H16F7N7O/c27-17-10-15(39-12-36-19-9-14(25(28,29)30)4-7-20(19)39)5-6-18(17)37-24(41)21-11-22(26(31,32)33)38-40(21)16-3-1-2-13(8-16)23(34)35/h1-12H,(H3,34,35)(H,37,41) LBFYGRDPTBUEKV-UHFFFAOYSA-N 12760 1-(3-carbamimidoylphenyl)-N-{2-fluoro-4-[5-(trifluoromethyl)-1H-1,3-benzodiazol-1-yl]phenyl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3i Coagulation factor X Homo sapiens 0.29 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12760&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646195 46513207 ZINC14950670 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22933 Cc1ccc2n(cnc2c1)-c1ccc(NC(=O)c2cc(nn2-c2cccc(c2)C(N)=N)C(F)(F)F)c(F)c1 InChI=1S/C26H19F4N7O/c1-14-5-8-21-20(9-14)33-13-36(21)16-6-7-19(18(27)11-16)34-25(38)22-12-23(26(28,29)30)35-37(22)17-4-2-3-15(10-17)24(31)32/h2-13H,1H3,(H3,31,32)(H,34,38) QIIJPFFGWFOIHG-UHFFFAOYSA-N 12761 1-(3-carbamimidoylphenyl)-N-[2-fluoro-4-(5-methyl-1H-1,3-benzodiazol-1-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3j Coagulation factor X Homo sapiens 0.27 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12761&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646196 46513208 ZINC14950673 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22934 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1cnc2cc(N)ccc12)C(F)(F)F InChI=1S/C25H18F4N8O/c26-17-10-15(36-12-33-19-9-14(30)4-7-20(19)36)5-6-18(17)34-24(38)21-11-22(25(27,28)29)35-37(21)16-3-1-2-13(8-16)23(31)32/h1-12H,30H2,(H3,31,32)(H,34,38) SZCUDERAYZVADS-UHFFFAOYSA-N 12762 N-[4-(5-amino-1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-1-(3-carbamimidoylphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3k Coagulation factor X Homo sapiens 0.12 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12762&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646197 46513209 ZINC14950676 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22935 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1cnc2cc(ccc12)[N+]([O-])=O)C(F)(F)F InChI=1S/C25H16F4N8O3/c26-17-9-14(35-12-32-19-10-16(37(39)40)5-7-20(19)35)4-6-18(17)33-24(38)21-11-22(25(27,28)29)34-36(21)15-3-1-2-13(8-15)23(30)31/h1-12H,(H3,30,31)(H,33,38) WUSRGHHERUYXLJ-UHFFFAOYSA-N 12763 1-(3-carbamimidoylphenyl)-N-[2-fluoro-4-(5-nitro-1H-1,3-benzodiazol-1-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3l Coagulation factor X Homo sapiens 0.08 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12763&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646198 46513210 ZINC14950679 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22936 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1cnc2cc(Cl)c(Cl)cc12)C(F)(F)F InChI=1S/C25H15Cl2F4N7O/c26-15-8-19-20(9-16(15)27)37(11-34-19)13-4-5-18(17(28)7-13)35-24(39)21-10-22(25(29,30)31)36-38(21)14-3-1-2-12(6-14)23(32)33/h1-11H,(H3,32,33)(H,35,39) OWWJAGHMUKHZEI-UHFFFAOYSA-N 12764 1-(3-carbamimidoylphenyl)-N-[4-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3m Coagulation factor X Homo sapiens 0.27 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12764&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646199 46513211 ZINC14950682 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22937 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1F)-n1ccc2ccccc12)C(F)(F)F InChI=1S/C26H18F4N6O/c27-19-13-17(35-11-10-15-4-1-2-7-21(15)35)8-9-20(19)33-25(37)22-14-23(26(28,29)30)34-36(22)18-6-3-5-16(12-18)24(31)32/h1-14H,(H3,31,32)(H,33,37) IOUJEXDJFKAVEA-UHFFFAOYSA-N 12765 1-(3-carbamimidoylphenyl)-N-[2-fluoro-4-(1H-indol-1-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3n Coagulation factor X Homo sapiens 5.4 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12765&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646200 46513212 ZINC14950686 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22938 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1)-n1c2ccccc2[nH]c1=O)C(F)(F)F InChI=1S/C25H18F3N7O2/c26-25(27,28)21-13-20(35(33-21)17-5-3-4-14(12-17)22(29)30)23(36)31-15-8-10-16(11-9-15)34-19-7-2-1-6-18(19)32-24(34)37/h1-13H,(H3,29,30)(H,31,36)(H,32,37) MUYVTPFWLRLNDQ-UHFFFAOYSA-N 12766 1-(3-carbamimidoylphenyl)-N-[4-(2-oxo-2,7a-dihydro-1H-1,3-benzodiazol-1-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3o Coagulation factor X Homo sapiens 0.058 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12766&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91895877 46513213 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22939 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1)-n1ccnc1)C(F)(F)F InChI=1S/C21H16F3N7O/c22-21(23,24)18-11-17(31(29-18)16-3-1-2-13(10-16)19(25)26)20(32)28-14-4-6-15(7-5-14)30-9-8-27-12-30/h1-12H,(H3,25,26)(H,28,32) MBUSOSLPKAWWDF-UHFFFAOYSA-N 12767 1-(3-carbamimidoylphenyl)-N-[4-(1H-imidazol-1-yl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 3p Coagulation factor X Homo sapiens 0.091 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12767&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18549509 46513214 ZINC14950695 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22940 NC(=N)c1cccc(c1)-n1nc(Cn2ccnc2)cc1C(=O)Nc1ccc(cc1)-n1cnc2ccccc12 InChI=1S/C28H23N9O/c29-27(30)19-4-3-5-23(14-19)37-26(15-21(34-37)16-35-13-12-31-17-35)28(38)33-20-8-10-22(11-9-20)36-18-32-24-6-1-2-7-25(24)36/h1-15,17-18H,16H2,(H3,29,30)(H,33,38) DGDYVKYCUQMCEL-UHFFFAOYSA-N 12768 N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-1-(3-carbamimidoylphenyl)-3-(1H-imidazol-1-ylmethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 8a Coagulation factor X Homo sapiens 0.58 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12768&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646202 46513215 ZINC14950699 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22941 Cc1ncn(n1)-c1cc(C(=O)Nc2ccc(cc2)-n2cnc3ccccc23)n(n1)-c1cccc(c1)C(N)=N InChI=1S/C27H22N10O/c1-17-30-16-36(33-17)25-14-24(37(34-25)21-6-4-5-18(13-21)26(28)29)27(38)32-19-9-11-20(12-10-19)35-15-31-22-7-2-3-8-23(22)35/h2-16H,1H3,(H3,28,29)(H,32,38) CTMWQKHAKINJBQ-UHFFFAOYSA-N 12769 N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-1-(3-carbamimidoylphenyl)-3-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrazole-5-carboxamide::pyrazole analog 8b Coagulation factor X Homo sapiens 0.19 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12769&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646203 46513216 ZINC14950702 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22942 NC(=N)c1cccc(c1)-n1nc(Cn2ccnn2)cc1C(=O)Nc1ccc(cc1)-n1cnc2ccccc12 InChI=1S/C27H22N10O/c28-26(29)18-4-3-5-22(14-18)37-25(15-20(33-37)16-35-13-12-31-34-35)27(38)32-19-8-10-21(11-9-19)36-17-30-23-6-1-2-7-24(23)36/h1-15,17H,16H2,(H3,28,29)(H,32,38) LQFYPYCYEHAMOM-UHFFFAOYSA-N 12770 N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-1-(3-carbamimidoylphenyl)-3-(1H-1,2,3-triazol-1-ylmethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 8c Coagulation factor X Homo sapiens 0.26 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12770&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646204 46513217 ZINC14950706 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22943 NC(=N)c1cccc(c1)-n1nc(Cn2cnnn2)cc1C(=O)Nc1ccc(cc1)-n1cnc2ccccc12 InChI=1S/C26H21N11O/c27-25(28)17-4-3-5-21(12-17)37-24(13-19(32-37)14-35-16-30-33-34-35)26(38)31-18-8-10-20(11-9-18)36-15-29-22-6-1-2-7-23(22)36/h1-13,15-16H,14H2,(H3,27,28)(H,31,38) BYZNFHGPFLCXLX-UHFFFAOYSA-N 12771 N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-1-(3-carbamimidoylphenyl)-3-(1H-1,2,3,4-tetrazol-1-ylmethyl)-1H-pyrazole-5-carboxamide::pyrazole analog 8d Coagulation factor X Homo sapiens 0.31 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12771&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646205 46513218 ZINC14950710 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22944 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1)-n1cnc2ccccc12)-c1cccnc1 InChI=1S/C29H22N8O/c30-28(31)19-5-3-7-23(15-19)37-27(16-25(35-37)20-6-4-14-32-17-20)29(38)34-21-10-12-22(13-11-21)36-18-33-24-8-1-2-9-26(24)36/h1-18H,(H3,30,31)(H,34,38) YPCCPZGSXDLRRE-UHFFFAOYSA-N 12772 N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-1-(3-carbamimidoylphenyl)-3-(pyridin-3-yl)-1H-pyrazole-5-carboxamide::pyrazole analog 8e Coagulation factor X Homo sapiens 0.20 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12772&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646206 46513219 ZINC14950715 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22945 NC(=N)c1cccc(c1)-n1nc(cc1C(=O)Nc1ccc(cc1)-n1cnc2cc(Cl)ccc12)-c1cccnc1 InChI=1S/C29H21ClN8O/c30-20-6-11-26-25(14-20)34-17-37(26)22-9-7-21(8-10-22)35-29(39)27-15-24(19-4-2-12-33-16-19)36-38(27)23-5-1-3-18(13-23)28(31)32/h1-17H,(H3,31,32)(H,35,39) YKXILNHOJFGFJF-UHFFFAOYSA-N 12773 1-(3-carbamimidoylphenyl)-N-[4-(5-chloro-1H-1,3-benzodiazol-1-yl)phenyl]-3-(pyridin-3-yl)-1H-pyrazole-5-carboxamide::pyrazole analog 8f Coagulation factor X Homo sapiens 0.65 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.034 10.7270/Q2TH8JX0 15454208 aid1796940 Smallheer, JM; Alexander, RS; Wang, J; Wang, S; Nakajima, S; Rossi, KA; Smallwood, A; Barbera, F; Burdick, D; Luettgen, JM; Knabb, RM; Wexler, RR; Jadhav, PK Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12773&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646207 46513220 ZINC14950719 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22970 NC(=N)c1ccc2[nH]cc(CC(=O)Nc3ccc(cc3)-c3ccccc3S(N)(=O)=O)c2c1 InChI=1S/C23H21N5O3S/c24-23(25)15-7-10-20-19(11-15)16(13-27-20)12-22(29)28-17-8-5-14(6-9-17)18-3-1-2-4-21(18)32(26,30)31/h1-11,13,27H,12H2,(H3,24,25)(H,28,29)(H2,26,30,31) HTUXSSSIXKJFED-UHFFFAOYSA-N 12775 2-(5-carbamimidoyl-1H-indol-3-yl)-N-[4-(2-sulfamoylphenyl)phenyl]acetamide::5-amidinoindole 1::CHEMBL136846 Coagulation factor X Homo sapiens 3.2 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12775&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 15511974 46513221 CHEMBL136846 ZINC13835119 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22971 NC(=N)c1ccc2[nH]cc(C(Cc3ccccc3)C(=O)Nc3ccc(cc3)-c3ccccc3S(N)(=O)=O)c2c1 InChI=1S/C30H27N5O3S/c31-29(32)21-12-15-27-24(17-21)26(18-34-27)25(16-19-6-2-1-3-7-19)30(36)35-22-13-10-20(11-14-22)23-8-4-5-9-28(23)39(33,37)38/h1-15,17-18,25,34H,16H2,(H3,31,32)(H,35,36)(H2,33,37,38) SRWVIUSCTTYZOM-UHFFFAOYSA-N 12776 2-(5-carbamimidoyl-1H-indol-3-yl)-3-phenyl-N-[4-(2-sulfamoylphenyl)phenyl]propanamide::5-amidinoindole 2 Coagulation factor X Homo sapiens 0.63 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12776&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646208 46513222 ZINC14950732 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22972 NC(=N)c1ccc2[nH]cc(C(Cc3ccccc3)C(=O)Nc3ccc(cc3F)-n3cnc4ccccc34)c2c1 InChI=1S/C31H25FN6O/c32-25-16-21(38-18-36-28-8-4-5-9-29(28)38)11-13-27(25)37-31(39)23(14-19-6-2-1-3-7-19)24-17-35-26-12-10-20(30(33)34)15-22(24)26/h1-13,15-18,23,35H,14H2,(H3,33,34)(H,37,39) OREKERSNHHDONJ-UHFFFAOYSA-N 12777 5-amidinoindole 13a::N-[4-(1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)-3-phenylpropanamide::amidinoindole 20 Coagulation factor X Homo sapiens 2.5 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12777&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646209 46513223 ZINC14950740 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22973 NC(=N)c1ccc2[nH]cc([C@@H](Cc3ccccc3)C(=O)Nc3ccc(cc3F)-n3cnc4ccccc34)c2c1 InChI=1S/C31H25FN6O/c32-25-16-21(38-18-36-28-8-4-5-9-29(28)38)11-13-27(25)37-31(39)23(14-19-6-2-1-3-7-19)24-17-35-26-12-10-20(30(33)34)15-22(24)26/h1-13,15-18,23,35H,14H2,(H3,33,34)(H,37,39)/t23-/m1/s1 OREKERSNHHDONJ-HSZRJFAPSA-N 12778 (2R)-N-[4-(1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)-3-phenylpropanamide::(R)-(-)::5-amidinoindole 13b Coagulation factor X Homo sapiens 1.3 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12778&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646210 46513224 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22974 NC(=N)c1ccc2[nH]cc([C@H](Cc3ccccc3)C(=O)Nc3ccc(cc3F)-n3cnc4ccccc34)c2c1 InChI=1S/C31H25FN6O/c32-25-16-21(38-18-36-28-8-4-5-9-29(28)38)11-13-27(25)37-31(39)23(14-19-6-2-1-3-7-19)24-17-35-26-12-10-20(30(33)34)15-22(24)26/h1-13,15-18,23,35H,14H2,(H3,33,34)(H,37,39)/t23-/m0/s1 OREKERSNHHDONJ-QHCPKHFHSA-N 12779 (2S)-N-[4-(1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)-3-phenylpropanamide::(S)-(+)::5-amidinoindole 13c Coagulation factor X Homo sapiens 26 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12779&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646211 46513225 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22975 CC(C(=O)Nc1ccc(cc1)-n1cnc2ccccc12)c1c[nH]c2ccc(cc12)C(N)=N InChI=1S/C25H22N6O/c1-15(20-13-28-21-11-6-16(24(26)27)12-19(20)21)25(32)30-17-7-9-18(10-8-17)31-14-29-22-4-2-3-5-23(22)31/h2-15,28H,1H3,(H3,26,27)(H,30,32) AFEFYKVGLKZFNF-UHFFFAOYSA-N 12780 5-amidinoindole 14::N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)propanamide Coagulation factor X Homo sapiens 3 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12780&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646212 46513226 ZINC14950748 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22976 CC(C)(C(=O)Nc1ccc(cc1)-n1cnc2ccccc12)c1c[nH]c2ccc(cc12)C(N)=N InChI=1S/C26H24N6O/c1-26(2,20-14-29-21-12-7-16(24(27)28)13-19(20)21)25(33)31-17-8-10-18(11-9-17)32-15-30-22-5-3-4-6-23(22)32/h3-15,29H,1-2H3,(H3,27,28)(H,31,33) NIEHJKGSSZTFAO-UHFFFAOYSA-N 12781 5-amidinoindole 15::N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)-2-methylpropanamide Coagulation factor X Homo sapiens 2.2 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12781&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646213 46513227 ZINC14950753 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22977 CCC(C(=O)Nc1ccc(cc1)-n1cnc2ccccc12)c1c[nH]c2ccc(cc12)C(N)=N InChI=1S/C26H24N6O/c1-2-19(21-14-29-22-12-7-16(25(27)28)13-20(21)22)26(33)31-17-8-10-18(11-9-17)32-15-30-23-5-3-4-6-24(23)32/h3-15,19,29H,2H2,1H3,(H3,27,28)(H,31,33) MVIMTQPKTBMOAO-UHFFFAOYSA-N 12782 5-amidinoindole 16::N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)butanamide Coagulation factor X Homo sapiens 2.8 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12782&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646214 46513228 ZINC14950762 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22978 NC(=N)c1ccc2[nH]cc(C(CC3CC3)C(=O)Nc3ccc(cc3)-n3cnc4ccccc34)c2c1 InChI=1S/C28H26N6O/c29-27(30)18-7-12-24-21(14-18)23(15-31-24)22(13-17-5-6-17)28(35)33-19-8-10-20(11-9-19)34-16-32-25-3-1-2-4-26(25)34/h1-4,7-12,14-17,22,31H,5-6,13H2,(H3,29,30)(H,33,35) MNWGSJRYECRAHJ-UHFFFAOYSA-N 12783 5-amidinoindole 17::N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)-3-cyclopropylpropanamide Coagulation factor X Homo sapiens 14 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12783&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646215 46513229 ZINC14950770 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22979 NC(=N)c1ccc2[nH]cc(C(CCc3ccccc3)C(=O)Nc3ccc(cc3F)-n3cnc4ccccc34)c2c1 InChI=1S/C32H27FN6O/c33-26-17-22(39-19-37-29-8-4-5-9-30(29)39)12-15-28(26)38-32(40)23(13-10-20-6-2-1-3-7-20)25-18-36-27-14-11-21(31(34)35)16-24(25)27/h1-9,11-12,14-19,23,36H,10,13H2,(H3,34,35)(H,38,40) NJOJGBCXGMXSRK-UHFFFAOYSA-N 12784 5-amidinoindole 18::N-[4-(1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)-4-phenylbutanamide Coagulation factor X Homo sapiens 6.1 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12784&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646216 46513230 ZINC14950780 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22980 NC(=N)c1ccc2[nH]cc(C(Cc3ccc4ccccc4c3)C(=O)Nc3ccc(cc3F)-n3cnc4ccccc34)c2c1 InChI=1S/C35H27FN6O/c36-29-18-25(42-20-40-32-7-3-4-8-33(32)42)12-14-31(29)41-35(43)27(16-21-9-10-22-5-1-2-6-23(22)15-21)28-19-39-30-13-11-24(34(37)38)17-26(28)30/h1-15,17-20,27,39H,16H2,(H3,37,38)(H,41,43) VRTLCVDTLDWAER-UHFFFAOYSA-N 12785 5-amidinoindole 19::N-[4-(1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)-3-(naphthalen-2-yl)propanamide Coagulation factor X Homo sapiens 28 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12785&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646217 46513231 ZINC14950789 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22981 NC(=N)c1ccc2[nH]cc(C(Cc3cccc(c3)C(O)=O)C(=O)Nc3ccc(cc3F)-n3cnc4ccccc34)c2c1 InChI=1S/C32H25FN6O3/c33-25-15-21(39-17-37-28-6-1-2-7-29(28)39)9-11-27(25)38-31(40)23(13-18-4-3-5-20(12-18)32(41)42)24-16-36-26-10-8-19(30(34)35)14-22(24)26/h1-12,14-17,23,36H,13H2,(H3,34,35)(H,38,40)(H,41,42) BQYOJZIZDYPTRZ-UHFFFAOYSA-N 12786 3-(2-{[4-(1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]carbamoyl}-2-(5-carbamimidoyl-1H-indol-3-yl)ethyl)benzoic acid::5-amidinoindole 20 Coagulation factor X Homo sapiens 1.8 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12786&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10325481 46513232 ZINC14950796 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22982 NC(=N)c1ccc2[nH]cc(C(Cc3ccc(N)cc3)C(=O)Nc3ccc(cc3)-n3cnc4ccccc34)c2c1 InChI=1S/C31H27N7O/c32-21-8-5-19(6-9-21)15-25(26-17-35-27-14-7-20(30(33)34)16-24(26)27)31(39)37-22-10-12-23(13-11-22)38-18-36-28-3-1-2-4-29(28)38/h1-14,16-18,25,35H,15,32H2,(H3,33,34)(H,37,39) SAOAIXOGVSHQNA-UHFFFAOYSA-N 12787 3-(4-aminophenyl)-N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)propanamide::5-amidinoindole 21::amidinoindole 22 Coagulation factor X Homo sapiens 4 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12787&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646218 46513233 ZINC14950804 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22983 NC(=N)c1ccc2[nH]cc(C(Cc3cccnc3)C(=O)Nc3ccc(cc3)-n3cnc4ccccc34)c2c1 InChI=1S/C30H25N7O/c31-29(32)20-7-12-26-23(15-20)25(17-34-26)24(14-19-4-3-13-33-16-19)30(38)36-21-8-10-22(11-9-21)37-18-35-27-5-1-2-6-28(27)37/h1-13,15-18,24,34H,14H2,(H3,31,32)(H,36,38) VBDBTLANBDJZRR-UHFFFAOYSA-N 12788 5-amidinoindole 22::N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)-3-(pyridin-3-yl)propanamide Coagulation factor X Homo sapiens 7 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12788&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646219 46513234 ZINC14950812 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22984 NC(=N)c1ccc2[nH]cc(C(Cc3ccc(NC(=O)c4ccccc4)cc3)C(=O)Nc3ccc(cc3)-n3cnc4ccccc34)c2c1 InChI=1S/C38H31N7O2/c39-36(40)26-12-19-33-30(21-26)32(22-41-33)31(20-24-10-13-27(14-11-24)43-37(46)25-6-2-1-3-7-25)38(47)44-28-15-17-29(18-16-28)45-23-42-34-8-4-5-9-35(34)45/h1-19,21-23,31,41H,20H2,(H3,39,40)(H,43,46)(H,44,47) RPUAJKDGVVDDHX-UHFFFAOYSA-N 12789 5-amidinoindole 23::N-[4-(2-{[4-(1H-1,3-benzodiazol-1-yl)phenyl]carbamoyl}-2-(5-carbamimidoyl-1H-indol-3-yl)ethyl)phenyl]benzamide Coagulation factor X Homo sapiens 18 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12789&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646220 46513235 ZINC14950820 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22985 NC(=N)c1ccc2[nH]cc(C(Cc3ccc(NS(=O)(=O)c4ccccc4)cc3)C(=O)Nc3ccc(cc3)-n3cnc4ccccc34)c2c1 InChI=1S/C37H31N7O3S/c38-36(39)25-12-19-33-30(21-25)32(22-40-33)31(20-24-10-13-27(14-11-24)43-48(46,47)29-6-2-1-3-7-29)37(45)42-26-15-17-28(18-16-26)44-23-41-34-8-4-5-9-35(34)44/h1-19,21-23,31,40,43H,20H2,(H3,38,39)(H,42,45) RXXVGNIRWRKRRT-UHFFFAOYSA-N 12790 3-(4-benzenesulfonamidophenyl)-N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)propanamide::5-amidinoindole 24 Coagulation factor X Homo sapiens 19 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12790&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646221 46513236 ZINC28396078 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22986 NC(=N)c1ccc2ccn(C(Cc3ccccc3)C(=O)Nc3ccc(cc3F)-n3cnc4ccccc34)c2c1 InChI=1S/C31H25FN6O/c32-24-18-23(38-19-35-26-8-4-5-9-27(26)38)12-13-25(24)36-31(39)29(16-20-6-2-1-3-7-20)37-15-14-21-10-11-22(30(33)34)17-28(21)37/h1-15,17-19,29H,16H2,(H3,33,34)(H,36,39) RMYBTCLUWIJGRT-UHFFFAOYSA-N 12791 6-amidinoindole 25::N-[4-(1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-2-(6-carbamimidoyl-1H-indol-1-yl)-3-phenylpropanamide Coagulation factor X Homo sapiens 5.6 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12791&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646222 46513237 ZINC14950829 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22987 Cn1cc(C(Cc2ccccc2)C(=O)Nc2ccc(cc2F)-n2cnc3ccccc23)c2cc(ccc12)C(N)=N InChI=1S/C32H27FN6O/c1-38-18-25(23-16-21(31(34)35)11-14-29(23)38)24(15-20-7-3-2-4-8-20)32(40)37-27-13-12-22(17-26(27)33)39-19-36-28-9-5-6-10-30(28)39/h2-14,16-19,24H,15H2,1H3,(H3,34,35)(H,37,40) CULRMGDBJLVUDS-UHFFFAOYSA-N 12792 5-amidinoindole 26::N-[4-(1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-2-(5-carbamimidoyl-1-methyl-1H-indol-3-yl)-3-phenylpropanamide Coagulation factor X Homo sapiens 160 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12792&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646223 46513238 ZINC14950838 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22988 NC(=N)c1ccc2[nH]cc(CC(Cc3ccccc3)C(=O)Nc3ccc(cc3)-n3cnc4ccccc34)c2c1 InChI=1S/C32H28N6O/c33-31(34)22-10-15-28-27(18-22)24(19-35-28)17-23(16-21-6-2-1-3-7-21)32(39)37-25-11-13-26(14-12-25)38-20-36-29-8-4-5-9-30(29)38/h1-15,18-20,23,35H,16-17H2,(H3,33,34)(H,37,39) SLHUHWJCKCRBLN-UHFFFAOYSA-N 12793 5-amidinoindole 27::N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-2-[(5-carbamimidoyl-1H-indol-3-yl)methyl]-3-phenylpropanamide Coagulation factor X Homo sapiens 45 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12793&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646224 46513239 ZINC14950846 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22989 NC(=N)c1ccc2[nH]cc(C(CC(=O)Nc3ccc(cc3)-n3cnc4ccccc34)Cc3ccccc3)c2c1 InChI=1S/C32H28N6O/c33-32(34)22-10-15-28-26(17-22)27(19-35-28)23(16-21-6-2-1-3-7-21)18-31(39)37-24-11-13-25(14-12-24)38-20-36-29-8-4-5-9-30(29)38/h1-15,17,19-20,23,35H,16,18H2,(H3,33,34)(H,37,39) GIJAFZZBRFHAFR-UHFFFAOYSA-N 12794 5-amidinoindole 28::N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-3-(5-carbamimidoyl-1H-indol-3-yl)-4-phenylbutanamide Coagulation factor X Homo sapiens 36 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12794&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646225 46513240 ZINC14950855 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22990 NC(=N)c1ccc2[nH]cc(C(Cc3ccccc3)C(=O)NCc3ccc(cc3)-n3cnc4ccccc34)c2c1 InChI=1S/C32H28N6O/c33-31(34)23-12-15-28-25(17-23)27(19-35-28)26(16-21-6-2-1-3-7-21)32(39)36-18-22-10-13-24(14-11-22)38-20-37-29-8-4-5-9-30(29)38/h1-15,17,19-20,26,35H,16,18H2,(H3,33,34)(H,36,39) YQUZVLWPXTXQDM-UHFFFAOYSA-N 12795 5-amidinoindole 29::N-{[4-(1H-1,3-benzodiazol-1-yl)phenyl]methyl}-2-(5-carbamimidoyl-1H-indol-3-yl)-3-phenylpropanamide Coagulation factor X Homo sapiens 72 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12795&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646226 46513241 ZINC14950866 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22991 NC(=N)c1ccc2[nH]cc(C(Cc3ccccc3)C(=O)NCc3ccc(cc3)C(=O)Nc3nc4ccccc4[nH]3)c2c1 InChI=1S/C33H29N7O2/c34-30(35)23-14-15-27-24(17-23)26(19-36-27)25(16-20-6-2-1-3-7-20)32(42)37-18-21-10-12-22(13-11-21)31(41)40-33-38-28-8-4-5-9-29(28)39-33/h1-15,17,19,25,36H,16,18H2,(H3,34,35)(H,37,42)(H2,38,39,40,41) IYMRRCSPSAPBJQ-UHFFFAOYSA-N 12796 5-amidinoindole 30::N-(1H-1,3-benzodiazol-2-yl)-4-{[2-(5-carbamimidoyl-1H-indol-3-yl)-3-phenylpropanamido]methyl}benzamide Coagulation factor X Homo sapiens 810 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12796&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646227 46513242 ZINC14950874 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22992 NC(=N)c1ccc2[nH]cc(C(Cc3ccccc3)C(=O)NCc3cccc(c3)C(=O)Nc3nc4ccccc4[nH]3)c2c1 InChI=1S/C33H29N7O2/c34-30(35)22-13-14-27-24(17-22)26(19-36-27)25(16-20-7-2-1-3-8-20)32(42)37-18-21-9-6-10-23(15-21)31(41)40-33-38-28-11-4-5-12-29(28)39-33/h1-15,17,19,25,36H,16,18H2,(H3,34,35)(H,37,42)(H2,38,39,40,41) RDPBUVKWMUSHAA-UHFFFAOYSA-N 12797 5-amidinoindole 31::N-(1H-1,3-benzodiazol-2-yl)-3-{[2-(5-carbamimidoyl-1H-indol-3-yl)-3-phenylpropanamido]methyl}benzamide Coagulation factor X Homo sapiens 2600 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12797&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646228 46513243 ZINC14950882 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22993 NC(=N)c1ccc2[nH]cc(C(Cc3ccccc3)C(=O)Nc3ccc(cc3)-n3cnc(c3)-c3ccccc3)c2c1 InChI=1S/C33H28N6O/c34-32(35)24-11-16-30-27(18-24)29(19-36-30)28(17-22-7-3-1-4-8-22)33(40)38-25-12-14-26(15-13-25)39-20-31(37-21-39)23-9-5-2-6-10-23/h1-16,18-21,28,36H,17H2,(H3,34,35)(H,38,40) MDFMMWJAJRKSRK-UHFFFAOYSA-N 12798 2-(5-carbamimidoyl-1H-indol-3-yl)-3-phenyl-N-[4-(4-phenyl-1H-imidazol-1-yl)phenyl]propanamide::5-amidinoindole 32 Coagulation factor X Homo sapiens 79 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12798&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646229 46513244 ZINC14950890 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22994 CS(=O)(=O)c1ccc2nc(NC(=O)c3ccc(CNC(=O)C(Cc4ccccc4)c4c[nH]c5ccc(cc45)C(N)=N)cc3)[nH]c2c1 InChI=1S/C34H31N7O4S/c1-46(44,45)24-12-14-29-30(17-24)40-34(39-29)41-32(42)22-9-7-21(8-10-22)18-38-33(43)26(15-20-5-3-2-4-6-20)27-19-37-28-13-11-23(31(35)36)16-25(27)28/h2-14,16-17,19,26,37H,15,18H2,1H3,(H3,35,36)(H,38,43)(H2,39,40,41,42) KYRYSUCVLCYOAP-UHFFFAOYSA-N 12799 4-{[2-(5-carbamimidoyl-1H-indol-3-yl)-3-phenylpropanamido]methyl}-N-(6-methanesulfonyl-1H-1,3-benzodiazol-2-yl)benzamide::5-amidinoindole 33 Coagulation factor X Homo sapiens 1100 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.08.037 10.7270/Q2PR7T6P 15454209 aid1796942 Batt, DG; Qiao, JX; Modi, DP; Houghton, GC; Pierson, DA; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12799&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646230 46513245 ZINC28394209 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23020 NC(=N)c1ccc2scc(C(Cc3ccccc3)C(=O)Nc3ccc(cc3)-n3cnc4ccccc34)c2c1 InChI=1S/C31H25N5OS/c32-30(33)21-10-15-29-24(17-21)26(18-38-29)25(16-20-6-2-1-3-7-20)31(37)35-22-11-13-23(14-12-22)36-19-34-27-8-4-5-9-28(27)36/h1-15,17-19,25H,16H2,(H3,32,33)(H,35,37) XQGUFFSRHKRUOB-UHFFFAOYSA-N 12800 2,2,2-trifluoroacetic acid; N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenylpropanamide::5-Amidinobenzo[b]thiophene 3 Coagulation factor X Homo sapiens 120 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12800&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646232 46513246 ZINC14950898 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23021 NC(=N)c1ccc2[nH]cc(C(Cc3ccccc3)C(=O)Nc3ccc(cc3F)-n3cnc4ccccc34)c2c1 InChI=1S/C31H25FN6O/c32-25-16-21(38-18-36-28-8-4-5-9-29(28)38)11-13-27(25)37-31(39)23(14-19-6-2-1-3-7-19)24-17-35-26-12-10-20(30(33)34)15-22(24)26/h1-13,15-18,23,35H,14H2,(H3,33,34)(H,37,39) OREKERSNHHDONJ-UHFFFAOYSA-N 12777 5-amidinoindole 13a::N-[4-(1H-1,3-benzodiazol-1-yl)-2-fluorophenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)-3-phenylpropanamide::amidinoindole 20 Coagulation factor X Homo sapiens 2.5 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12777&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646209 46513223 ZINC14950740 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23022 NC(=N)c1ccc2scc(C(Cc3ccc(N)cc3)C(=O)Nc3ccc(cc3)-n3cnc4ccccc34)c2c1 InChI=1S/C31H26N6OS/c32-21-8-5-19(6-9-21)15-25(26-17-39-29-14-7-20(30(33)34)16-24(26)29)31(38)36-22-10-12-23(13-11-22)37-18-35-27-3-1-2-4-28(27)37/h1-14,16-18,25H,15,32H2,(H3,33,34)(H,36,38) HXTWFGLEAQUYRO-UHFFFAOYSA-N 12802 2,2,2-trifluoroacetic acid; 3-(4-aminophenyl)-N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-2-(5-carbamimidoyl-1-benzothiophen-3-yl)propanamide::5-Amidinobenzo[b]thiophene 21 Coagulation factor X Homo sapiens 47 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12802&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646235 46513248 ZINC14950907 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23023 NC(=N)c1ccc2[nH]cc(C(Cc3ccc(N)cc3)C(=O)Nc3ccc(cc3)-n3cnc4ccccc34)c2c1 InChI=1S/C31H27N7O/c32-21-8-5-19(6-9-21)15-25(26-17-35-27-14-7-20(30(33)34)16-24(26)27)31(39)37-22-10-12-23(13-11-22)38-18-36-28-3-1-2-4-29(28)38/h1-14,16-18,25,35H,15,32H2,(H3,33,34)(H,37,39) SAOAIXOGVSHQNA-UHFFFAOYSA-N 12787 3-(4-aminophenyl)-N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-2-(5-carbamimidoyl-1H-indol-3-yl)propanamide::5-amidinoindole 21::amidinoindole 22 Coagulation factor X Homo sapiens 4 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12787&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646218 46513233 ZINC14950804 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23024 NC(=N)c1ccc2scc(C(Cc3cccc4ccccc34)C(=O)Nc3ccc(cc3)-n3cnc4ccccc34)c2c1 InChI=1S/C35H27N5OS/c36-34(37)24-12-17-33-28(19-24)30(20-42-33)29(18-23-8-5-7-22-6-1-2-9-27(22)23)35(41)39-25-13-15-26(16-14-25)40-21-38-31-10-3-4-11-32(31)40/h1-17,19-21,29H,18H2,(H3,36,37)(H,39,41) VPPDBPSKDXBZTP-UHFFFAOYSA-N 12804 2,2,2-trifluoroacetic acid; N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-(naphthalen-1-yl)propanamide::5-Amidinobenzo[b]thiophene 23 Coagulation factor X Homo sapiens 740 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12804&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646238 46513250 ZINC14950915 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23025 CCC(C(=O)Nc1ccc(cc1)-n1cnc2ccccc12)c1csc2ccc(cc12)C(N)=N InChI=1S/C26H23N5OS/c1-2-19(21-14-33-24-12-7-16(25(27)28)13-20(21)24)26(32)30-17-8-10-18(11-9-17)31-15-29-22-5-3-4-6-23(22)31/h3-15,19H,2H2,1H3,(H3,27,28)(H,30,32) UBYJNLCXFFBLPT-UHFFFAOYSA-N 12805 2,2,2-trifluoroacetic acid; N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-2-(5-carbamimidoyl-1-benzothiophen-3-yl)butanamide::5-Amidinobenzo[b]thiophene 24 Coagulation factor X Homo sapiens 71 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12805&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646240 46513251 ZINC14950923 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23026 NC(=N)c1ccc2scc(c2c1)C1(CC1)C(=O)Nc1ccc(cc1)-n1cnc2ccccc12 InChI=1S/C26H21N5OS/c27-24(28)16-5-10-23-19(13-16)20(14-33-23)26(11-12-26)25(32)30-17-6-8-18(9-7-17)31-15-29-21-3-1-2-4-22(21)31/h1-10,13-15H,11-12H2,(H3,27,28)(H,30,32) PSUWLRACXBOUOG-UHFFFAOYSA-N 12806 2,2,2-trifluoroacetic acid; N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-1-(5-carbamimidoyl-1-benzothiophen-3-yl)cyclopropane-1-carboxamide::5-Amidinobenzo[b]thiophene 25 Coagulation factor X Homo sapiens 22 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12806&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646242 46513252 ZINC14950926 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23027 NC(=N)c1ccc2scc(C(CC(=O)Nc3ccc(cc3)-n3cnc4ccccc34)Cc3ccccc3)c2c1 InChI=1S/C32H27N5OS/c33-32(34)22-10-15-30-26(17-22)27(19-39-30)23(16-21-6-2-1-3-7-21)18-31(38)36-24-11-13-25(14-12-24)37-20-35-28-8-4-5-9-29(28)37/h1-15,17,19-20,23H,16,18H2,(H3,33,34)(H,36,38) HOMLILSZEAMAIN-UHFFFAOYSA-N 12807 2,2,2-trifluoroacetic acid; N-[4-(1H-1,3-benzodiazol-1-yl)phenyl]-3-(5-carbamimidoyl-1-benzothiophen-3-yl)-4-phenylbutanamide::5-Amidinobenzo[b]thiophene 4 Coagulation factor X Homo sapiens 280 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12807&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646244 46513253 ZINC14950934 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23028 NC(=N)c1ccc2scc(C(Cc3ccccc3)C(=O)Nc3ccc(cc3)-n3cnc(c3)-c3ccccc3)c2c1 InChI=1S/C33H27N5OS/c34-32(35)24-11-16-31-27(18-24)29(20-40-31)28(17-22-7-3-1-4-8-22)33(39)37-25-12-14-26(15-13-25)38-19-30(36-21-38)23-9-5-2-6-10-23/h1-16,18-21,28H,17H2,(H3,34,35)(H,37,39) SFQJXKKBEULZHT-UHFFFAOYSA-N 12808 2,2,2-trifluoroacetic acid; 2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenyl-N-[4-(4-phenyl-1H-imidazol-1-yl)phenyl]propanamide::5-Amidinobenzo[b]thiophene 26 Coagulation factor X Homo sapiens 2020 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12808&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646246 46513254 ZINC14950945 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23029 NC(=N)c1ccc2scc(C(Cc3ccccc3)C(=O)Nc3ccc(cc3)S(=O)(=O)Nc3ccc(Cl)nn3)c2c1 InChI=1S/C28H23ClN6O3S2/c29-25-12-13-26(34-33-25)35-40(37,38)20-9-7-19(8-10-20)32-28(36)22(14-17-4-2-1-3-5-17)23-16-39-24-11-6-18(27(30)31)15-21(23)24/h1-13,15-16,22H,14H2,(H3,30,31)(H,32,36)(H,34,35) HGYNEVGCUIGPKE-UHFFFAOYSA-N 12809 2,2,2-trifluoroacetic acid; 2-(5-carbamimidoyl-1-benzothiophen-3-yl)-N-{4-[(6-chloropyridazin-3-yl)sulfamoyl]phenyl}-3-phenylpropanamide::5-Amidinobenzo[b]thiophene 27 Coagulation factor X Homo sapiens 5360 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12809&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646248 46513255 ZINC14950954 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23030 NC(=N)c1ccc2scc(C(Cc3ccccc3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2c1 InChI=1S/C30H25N3O2S/c31-29(32)21-11-16-28-25(18-21)27(19-36-28)26(17-20-7-3-1-4-8-20)30(34)33-22-12-14-24(15-13-22)35-23-9-5-2-6-10-23/h1-16,18-19,26H,17H2,(H3,31,32)(H,33,34) MHZNONWYVICPRR-UHFFFAOYSA-N 12810 2,2,2-trifluoroacetic acid; 2-(5-carbamimidoyl-1-benzothiophen-3-yl)-N-(4-phenoxyphenyl)-3-phenylpropanamide::5-Amidinobenzo[b]thiophene 28 Coagulation factor X Homo sapiens 450 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12810&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646250 46513256 ZINC14950962 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23031 NC(=N)c1ccc2scc(C(Cc3ccccc3)C(=O)Nc3ccc4ncsc4c3)c2c1 InChI=1S/C25H20N4OS2/c26-24(27)16-6-9-22-18(11-16)20(13-31-22)19(10-15-4-2-1-3-5-15)25(30)29-17-7-8-21-23(12-17)32-14-28-21/h1-9,11-14,19H,10H2,(H3,26,27)(H,29,30) WMOHPRLZMWOJBM-UHFFFAOYSA-N 12811 2,2,2-trifluoroacetic acid; N-(1,3-benzothiazol-6-yl)-2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenylpropanamide::5-Amidinobenzo[b]thiophene 29 Coagulation factor X Homo sapiens >8000 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12811&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11271039 46513257 ZINC14950971 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23032 NC(=N)c1ccc2scc(C(Cc3ccccc3)C(=O)Nc3ccc(cc3)C#N)c2c1 InChI=1S/C25H20N4OS/c26-14-17-6-9-19(10-7-17)29-25(30)21(12-16-4-2-1-3-5-16)22-15-31-23-11-8-18(24(27)28)13-20(22)23/h1-11,13,15,21H,12H2,(H3,27,28)(H,29,30) XFQIFKVQLRRJBF-UHFFFAOYSA-N 12812 2,2,2-trifluoroacetic acid; 2-(5-carbamimidoyl-1-benzothiophen-3-yl)-N-(4-cyanophenyl)-3-phenylpropanamide::5-Amidinobenzo[b]thiophene 30 Coagulation factor X Homo sapiens >8000 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12812&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646253 46513258 ZINC14950979 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23033 Cc1ccc(F)cc1NC(=O)C(Cc1ccccc1)c1csc2ccc(cc12)C(N)=N InChI=1S/C25H22FN3OS/c1-15-7-9-18(26)13-22(15)29-25(30)20(11-16-5-3-2-4-6-16)21-14-31-23-10-8-17(24(27)28)12-19(21)23/h2-10,12-14,20H,11H2,1H3,(H3,27,28)(H,29,30) AIYVHKHQIRBMIW-UHFFFAOYSA-N 12813 2,2,2-trifluoroacetic acid; 2-(5-carbamimidoyl-1-benzothiophen-3-yl)-N-(5-fluoro-2-methylphenyl)-3-phenylpropanamide::5-Amidinobenzo[b]thiophene 31 Coagulation factor X Homo sapiens >8000 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12813&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646255 46513259 ZINC14950987 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23034 CC1CCC(CC1)NC(=O)C(Cc1ccccc1)c1csc2ccc(cc12)C(N)=N InChI=1S/C25H29N3OS/c1-16-7-10-19(11-8-16)28-25(29)21(13-17-5-3-2-4-6-17)22-15-30-23-12-9-18(24(26)27)14-20(22)23/h2-6,9,12,14-16,19,21H,7-8,10-11,13H2,1H3,(H3,26,27)(H,28,29) GRRWSGURXRCOGN-UHFFFAOYSA-N 12814 2,2,2-trifluoroacetic acid; 2-(5-carbamimidoyl-1-benzothiophen-3-yl)-N-(4-methylcyclohexyl)-3-phenylpropanamide::5-Amidinobenzo[b]thiophene 32 Coagulation factor X Homo sapiens 3240 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12814&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646257 46513260 ZINC14950997 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23035 NC(=N)c1ccc2scc(C(Cc3ccccc3)C(=O)Nc3ccc(cc3)-n3ccc(n3)C(F)(F)F)c2c1 InChI=1S/C28H22F3N5OS/c29-28(30,31)25-12-13-36(35-25)20-9-7-19(8-10-20)34-27(37)22(14-17-4-2-1-3-5-17)23-16-38-24-11-6-18(26(32)33)15-21(23)24/h1-13,15-16,22H,14H2,(H3,32,33)(H,34,37) XMUNTFWDTAXUMK-UHFFFAOYSA-N 12815 2,2,2-trifluoroacetic acid; 2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenyl-N-{4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}propanamide::5-Amidinobenzo[b]thiophene 33 Coagulation factor X Homo sapiens 410 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12815&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646259 46513261 ZINC14951005 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23037 COC(=O)[C@H]1CCCC[C@H]1NC(=O)C(Cc1ccccc1)c1csc2ccc(cc12)C(N)=N InChI=1S/C26H29N3O3S/c1-32-26(31)18-9-5-6-10-22(18)29-25(30)20(13-16-7-3-2-4-8-16)21-15-33-23-12-11-17(24(27)28)14-19(21)23/h2-4,7-8,11-12,14-15,18,20,22H,5-6,9-10,13H2,1H3,(H3,27,28)(H,29,30)/t18-,20?,22+/m0/s1 XIAQRAMGKZHVGC-VRTQEHCBSA-N 12817 2,2,2-trifluoroacetic acid; methyl (1S,2R)-2-[2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenylpropanamido]cyclohexane-1-carboxylate::5-Amidinobenzo[b]thiophene 11a Coagulation factor X Homo sapiens 300 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12817&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646261 46513262 ZINC14951014 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23038 COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)C(Cc1ccccc1)c1csc2ccc(cc12)C(N)=N InChI=1S/C26H29N3O3S/c1-32-26(31)18-9-5-6-10-22(18)29-25(30)20(13-16-7-3-2-4-8-16)21-15-33-23-12-11-17(24(27)28)14-19(21)23/h2-4,7-8,11-12,14-15,18,20,22H,5-6,9-10,13H2,1H3,(H3,27,28)(H,29,30)/t18-,20?,22+/m1/s1 XIAQRAMGKZHVGC-PJDJYQKSSA-N 12818 2,2,2-trifluoroacetic acid; methyl (1R,2S)-2-[2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenylpropanamido]cyclohexane-1-carboxylate::5-Amidinobenzo[b]thiophene 11b Coagulation factor X Homo sapiens 90 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12818&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646263 46513263 ZINC14951022 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23039 COC(=O)[C@H]1CCCC[C@H]1NC(=O)[C@H](Cc1ccccc1)c1csc2ccc(cc12)C(N)=N InChI=1S/C26H29N3O3S/c1-32-26(31)18-9-5-6-10-22(18)29-25(30)20(13-16-7-3-2-4-8-16)21-15-33-23-12-11-17(24(27)28)14-19(21)23/h2-4,7-8,11-12,14-15,18,20,22H,5-6,9-10,13H2,1H3,(H3,27,28)(H,29,30)/t18-,20+,22+/m0/s1 XIAQRAMGKZHVGC-CZTZKLFOSA-N 12819 2,2,2-trifluoroacetic acid; methyl (1S,2R)-2-[(2R)-2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenylpropanamido]cyclohexane-1-carboxylate::5-Amidinobenzo[b]thiophene 11c Coagulation factor X Homo sapiens 270 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12819&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646265 46513264 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23040 COC(=O)[C@H]1CCCC[C@H]1NC(=O)[C@@H](Cc1ccccc1)c1csc2ccc(cc12)C(N)=N InChI=1S/C26H29N3O3S/c1-32-26(31)18-9-5-6-10-22(18)29-25(30)20(13-16-7-3-2-4-8-16)21-15-33-23-12-11-17(24(27)28)14-19(21)23/h2-4,7-8,11-12,14-15,18,20,22H,5-6,9-10,13H2,1H3,(H3,27,28)(H,29,30)/t18-,20-,22+/m0/s1 XIAQRAMGKZHVGC-RCZSKKKRSA-N 12820 2,2,2-trifluoroacetic acid; methyl (1S,2R)-2-[(2S)-2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenylpropanamido]cyclohexane-1-carboxylate::5-Amidinobenzo[b]thiophene 11d Coagulation factor X Homo sapiens >9000 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12820&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646267 46513265 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23041 NC(=N)c1ccc2scc(C(Cc3ccccc3)C(=O)Nc3ccc4ncsc4c3)c2c1 InChI=1S/C25H20N4OS2/c26-24(27)16-6-9-22-18(11-16)20(13-31-22)19(10-15-4-2-1-3-5-15)25(30)29-17-7-8-21-23(12-17)32-14-28-21/h1-9,11-14,19H,10H2,(H3,26,27)(H,29,30) WMOHPRLZMWOJBM-UHFFFAOYSA-N 12811 2,2,2-trifluoroacetic acid; N-(1,3-benzothiazol-6-yl)-2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenylpropanamide::5-Amidinobenzo[b]thiophene 29 Coagulation factor X Homo sapiens >8000 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12811&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11271039 46513257 ZINC14950971 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23042 NC(=N)c1ccc2scc([C@@H](Cc3ccccc3)C(=O)Nc3ccc4ncsc4c3)c2c1 InChI=1S/C25H20N4OS2/c26-24(27)16-6-9-22-18(11-16)20(13-31-22)19(10-15-4-2-1-3-5-15)25(30)29-17-7-8-21-23(12-17)32-14-28-21/h1-9,11-14,19H,10H2,(H3,26,27)(H,29,30)/t19-/m1/s1 WMOHPRLZMWOJBM-LJQANCHMSA-N 12821 (2R)-N-(1,3-benzothiazol-6-yl)-2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenylpropanamide; 2,2,2-trifluoroacetic acid::5-Amidinobenzo[b]thiophene 29R::R-(-) Coagulation factor X Homo sapiens 2700 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12821&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11190304 46513266 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23043 NC(=N)c1ccc2scc([C@H](Cc3ccccc3)C(=O)Nc3ccc4ncsc4c3)c2c1 InChI=1S/C25H20N4OS2/c26-24(27)16-6-9-22-18(11-16)20(13-31-22)19(10-15-4-2-1-3-5-15)25(30)29-17-7-8-21-23(12-17)32-14-28-21/h1-9,11-14,19H,10H2,(H3,26,27)(H,29,30)/t19-/m0/s1 WMOHPRLZMWOJBM-IBGZPJMESA-N 12822 (2S)-N-(1,3-benzothiazol-6-yl)-2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenylpropanamide; 2,2,2-trifluoroacetic acid::5-Amidinobenzo[b]thiophene 29S Coagulation factor X Homo sapiens 5700 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12822&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646270 46513267 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23044 CCOC(=O)[C@@H]1CCCC[C@@H]1NC(=O)C(Cc1ccccc1)c1csc2ccc(cc12)C(N)=N InChI=1S/C27H31N3O3S/c1-2-33-27(32)19-10-6-7-11-23(19)30-26(31)21(14-17-8-4-3-5-9-17)22-16-34-24-13-12-18(25(28)29)15-20(22)24/h3-5,8-9,12-13,15-16,19,21,23H,2,6-7,10-11,14H2,1H3,(H3,28,29)(H,30,31)/t19-,21?,23+/m1/s1 MGUKYFJLHMIZJP-DHGPAQJLSA-N 12823 2,2,2-trifluoroacetic acid; ethyl (1R,2S)-2-[2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenylpropanamido]cyclohexane-1-carboxylate::5-Amidinobenzo[b]thiophene 34::cis-racemic Coagulation factor X Homo sapiens 180 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12823&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646272 46513268 ZINC14951030 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23045 CCNC(=O)[C@@H]1CCCC[C@@H]1NC(=O)C(Cc1ccccc1)c1csc2ccc(cc12)C(N)=N InChI=1S/C27H32N4O2S/c1-2-30-26(32)19-10-6-7-11-23(19)31-27(33)21(14-17-8-4-3-5-9-17)22-16-34-24-13-12-18(25(28)29)15-20(22)24/h3-5,8-9,12-13,15-16,19,21,23H,2,6-7,10-11,14H2,1H3,(H3,28,29)(H,30,32)(H,31,33)/t19-,21?,23+/m1/s1 NPKXHOKPLZTAIT-DHGPAQJLSA-N 12824 (1R,2S)-2-[2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenylpropanamido]-N-ethylcyclohexane-1-carboxamide; 2,2,2-trifluoroacetic acid::5-Amidinobenzo[b]thiophene 35::cis-racemic Coagulation factor X Homo sapiens 130 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12824&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646274 46513269 ZINC14951038 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25334 COC(=O)[C@H](Cc1cccc(c1)C(N)=N)[C@@H](C)NC(=O)c1ccc(cc1)-c1cccc(CN)c1 InChI=1S/C27H30N4O3/c1-17(24(27(33)34-2)15-18-5-3-8-23(13-18)25(29)30)31-26(32)21-11-9-20(10-12-21)22-7-4-6-19(14-22)16-28/h3-14,17,24H,15-16,28H2,1-2H3,(H3,29,30)(H,31,32)/t17-,24-/m1/s1 XFKVLKLCLYJKNF-MZNJEOGPSA-N 12597 CHEMBL48046::RPR128515::methyl (2R,3R)-2-{3-[amino(imino)methyl]benzyl}-3-({[3-(aminomethyl)-1,1-biphenyl-4-yl]carbonyl}amino)butanoate::methyl (2R,3R)-3-({4-[3-(aminomethyl)phenyl]phenyl}formamido)-2-[(3-carbamimidoylphenyl)methyl]butanoate Coagulation factor X Homo sapiens 0.9 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm000940u 10.7270/Q25H7DHP 10966741 aid1797147 Maignan, S; Guilloteau, JP; Pouzieux, S; Choi-Sledeski, YM; Becker, MR; Klein, SI; Ewing, WR; Pauls, HW; Spada, AP; Mikol, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12597&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search RPR 1F0U,1EZQ 5497056 46513052 CHEMBL48046 DB04424 ZINC03815583 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25335 O=C1[C@H](CCN1Cc1cc2ccncc2[nH]1)NS(=O)(=O)c1cc2ncccc2s1 InChI=1S/C19H17N5O3S2/c25-19-14(23-29(26,27)18-9-15-17(28-18)2-1-5-21-15)4-7-24(19)11-13-8-12-3-6-20-10-16(12)22-13/h1-3,5-6,8-10,14,22-23H,4,7,11H2/t14-/m0/s1 PLXOQMHGHDZMSX-AWEZNQCLSA-N 14057 N-[(3S)-1-(4,7-diazabicyclo[4.3.0]nona-2,4,8,10-tetraen-8-ylmethyl)-2-oxo-pyrrolidin-3-yl]-7-thia-2-azabicyclo[4.3.0]nona-2,4,8,10-tetraene-8-sulfonamide::N-[(3S)-2-oxo-1-{1H-pyrrolo[2,3-c]pyridin-2-ylmethyl}pyrrolidin-3-yl]thieno[3,2-b]pyridine-2-sulfonamide::RPR208707 Coagulation factor X Homo sapiens 18 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm000940u 10.7270/Q25H7DHP 10966741 aid1797147 Maignan, S; Guilloteau, JP; Pouzieux, S; Choi-Sledeski, YM; Becker, MR; Klein, SI; Ewing, WR; Pauls, HW; Spada, AP; Mikol, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14057&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search PR2 1F0S 445481 46514422 DB08426 ZINC03815573 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25336 Nc1nccc2ccc(CN3CC[C@H](NS(=O)(=O)c4cc5ncccc5s4)C3=O)cc12 InChI=1S/C21H19N5O3S2/c22-20-15-10-13(3-4-14(15)5-8-24-20)12-26-9-6-16(21(26)27)25-31(28,29)19-11-17-18(30-19)2-1-7-23-17/h1-5,7-8,10-11,16,25H,6,9,12H2,(H2,22,24)/t16-/m0/s1 NVKDOURNRJCKJE-INIZCTEOSA-N 14058 CHEMBL316053::N-[(3S)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxo-pyrrolidin-3-yl]-7-thia-2-azabicyclo[4.3.0]nona-2,4,8,10-tetraene-8-sulfonamide::N-[(3S)-1-[(1-aminoisoquinolin-7-yl)methyl]-2-oxopyrrolidin-3-yl]thieno[3,2-b]pyridine-2-sulfonamide::RPR208815 Coagulation factor X Homo sapiens 22 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm000940u 10.7270/Q25H7DHP 10966741 aid1797147 Maignan, S; Guilloteau, JP; Pouzieux, S; Choi-Sledeski, YM; Becker, MR; Klein, SI; Ewing, WR; Pauls, HW; Spada, AP; Mikol, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14058&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 815 1F0R 445480 46514423 CHEMBL316053 DB07261 ZINC18275342 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25337 NC(=N)c1ccc(O)c(CN2CC[C@H](NS(=O)(=O)c3cc4ncccc4s3)C2=O)c1 InChI=1S/C19H19N5O4S2/c20-18(21)11-3-4-15(25)12(8-11)10-24-7-5-13(19(24)26)23-30(27,28)17-9-14-16(29-17)2-1-6-22-14/h1-4,6,8-9,13,23,25H,5,7,10H2,(H3,20,21)/t13-/m0/s1 PQJGWYQPOHCEDO-ZDUSSCGKSA-N 14059 4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4.3.0]nona-2,4,7,10-tetraen-8-ylsulfonylamino)pyrrolidin-1-yl]methyl]benzenecarboximidamide::4-hydroxy-3-{[(3S)-2-oxo-3-{thieno[3,2-b]pyridine-2-sulfonamido}pyrrolidin-1-yl]methyl}benzene-1-carboximidamide::CHEMBL330572::RPR131247 Coagulation factor X Homo sapiens 0.7 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm000940u 10.7270/Q25H7DHP 10966741 aid1797147 Maignan, S; Guilloteau, JP; Pouzieux, S; Choi-Sledeski, YM; Becker, MR; Klein, SI; Ewing, WR; Pauls, HW; Spada, AP; Mikol, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14059&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search PR1 1F0T 5326514 46514424 CHEMBL330572 DB02744 ZINC03873901 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23046 NC(=O)CNC(=O)[C@@H]1CCCC[C@@H]1NC(=O)C(Cc1ccccc1)c1csc2ccc(cc12)C(N)=N InChI=1S/C27H31N5O3S/c28-24(33)14-31-26(34)18-8-4-5-9-22(18)32-27(35)20(12-16-6-2-1-3-7-16)21-15-36-23-11-10-17(25(29)30)13-19(21)23/h1-3,6-7,10-11,13,15,18,20,22H,4-5,8-9,12,14H2,(H2,28,33)(H3,29,30)(H,31,34)(H,32,35)/t18-,20?,22+/m1/s1 SRNISDFDJIOHDQ-PJDJYQKSSA-N 12825 2,2,2-trifluoroacetic acid; 2-(5-carbamimidoyl-1-benzothiophen-3-yl)-N-[(1S,2R)-2-[(carbamoylmethyl)carbamoyl]cyclohexyl]-3-phenylpropanamide::5-Amidinobenzo[b]thiophene 36::cis-racemic Coagulation factor X Homo sapiens 65 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12825&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646276 46513270 ZINC14951045 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23047 NC(=N)c1ccc2scc(C(Cc3ccccc3)C(=O)N[C@H]3CCCC[C@H]3C(=O)NCc3ccccc3)c2c1 InChI=1S/C32H34N4O2S/c33-30(34)23-15-16-29-25(18-23)27(20-39-29)26(17-21-9-3-1-4-10-21)32(38)36-28-14-8-7-13-24(28)31(37)35-19-22-11-5-2-6-12-22/h1-6,9-12,15-16,18,20,24,26,28H,7-8,13-14,17,19H2,(H3,33,34)(H,35,37)(H,36,38)/t24-,26?,28+/m1/s1 BILPYABKAWIYLJ-VTBJCVEASA-N 12826 (1R,2S)-N-benzyl-2-[2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenylpropanamido]cyclohexane-1-carboxamide; 2,2,2-trifluoroacetic acid::5-Amidinobenzo[b]thiophene 37::cis-racemic Coagulation factor X Homo sapiens >9000 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12826&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646278 46513271 ZINC14951058 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23048 NC(=N)c1ccc2scc(C(Cc3ccccc3)C(=O)N[C@H]3CCCC[C@H]3C(O)=O)c2c1 InChI=1S/C25H27N3O3S/c26-23(27)16-10-11-22-18(13-16)20(14-32-22)19(12-15-6-2-1-3-7-15)24(29)28-21-9-5-4-8-17(21)25(30)31/h1-3,6-7,10-11,13-14,17,19,21H,4-5,8-9,12H2,(H3,26,27)(H,28,29)(H,30,31)/t17-,19?,21+/m1/s1 QSCIZBQDANXSKY-INMVSHNGSA-N 12827 (1R,2S)-2-[2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-phenylpropanamido]cyclohexane-1-carboxylic acid; 2,2,2-trifluoroacetic acid::5-Amidinobenzo[b]thiophene 38::cis-racemic Coagulation factor X Homo sapiens 200 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12827&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646280 46513272 ZINC14951069 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23049 COC(=O)[C@@H]1CCCC[C@@H]1NC(=O)C(Cc1ccccc1)c1c[nH]c2ccc(cc12)C(N)=N InChI=1S/C26H30N4O3/c1-33-26(32)18-9-5-6-10-23(18)30-25(31)20(13-16-7-3-2-4-8-16)21-15-29-22-12-11-17(24(27)28)14-19(21)22/h2-4,7-8,11-12,14-15,18,20,23,29H,5-6,9-10,13H2,1H3,(H3,27,28)(H,30,31)/t18-,20?,23+/m1/s1 QYQFYCXVJNUNSF-RAWUHTOPSA-N 12828 2,2,2-trifluoroacetic acid; methyl (1R,2S)-2-[2-(5-carbamimidoyl-1H-indol-3-yl)-3-phenylpropanamido]cyclohexane-1-carboxylate::amidinoindole 39 Coagulation factor X Homo sapiens 19 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12828&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646282 46513273 ZINC14951079 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23050 CCOC(=O)[C@@H]1CCCC[C@@H]1NC(=O)C(Cc1ccccc1)c1coc2ccc(cc12)C(N)=N InChI=1S/C27H31N3O4/c1-2-33-27(32)19-10-6-7-11-23(19)30-26(31)21(14-17-8-4-3-5-9-17)22-16-34-24-13-12-18(25(28)29)15-20(22)24/h3-5,8-9,12-13,15-16,19,21,23H,2,6-7,10-11,14H2,1H3,(H3,28,29)(H,30,31)/t19-,21?,23+/m1/s1 ALQRDVOSAXNUHX-DHGPAQJLSA-N 12829 2,2,2-trifluoroacetic acid; ethyl (1R,2S)-2-[2-(5-carbamimidoyl-1-benzofuran-3-yl)-3-phenylpropanamido]cyclohexane-1-carboxylate::5-amidinobenzo[b]furan 15 Coagulation factor X Homo sapiens 270 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12829&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646284 46513274 ZINC14951088 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23051 CCOC(=O)[C@@H]1CCCC[C@@H]1NC(=O)C(Cc1ccccc1)C1=CS(=O)(=O)c2ccc(cc12)C(N)=N InChI=1S/C27H31N3O5S/c1-2-35-27(32)19-10-6-7-11-23(19)30-26(31)21(14-17-8-4-3-5-9-17)22-16-36(33,34)24-13-12-18(25(28)29)15-20(22)24/h3-5,8-9,12-13,15-16,19,21,23H,2,6-7,10-11,14H2,1H3,(H3,28,29)(H,30,31)/t19-,21?,23+/m1/s1 IJAUZAZYLHIGKV-DHGPAQJLSA-N 12830 2,2,2-trifluoroacetic acid; ethyl (1R,2S)-2-[2-(5-carbamimidoyl-1,1-dioxo--benzothiophen-3-yl)-3-phenylpropanamido]cyclohexane-1-carboxylate::benzo[b]thiophene 1,1-dioxide 16 Coagulation factor X Homo sapiens >9000 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12830&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11352726 46513275 ZINC14951097 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23052 CCOC(=O)[C@@H]1CCCC[C@@H]1NC(=O)C(Cc1ccccc1)c1cccc2ccc(cc12)C(N)=N InChI=1S/C29H33N3O3/c1-2-35-29(34)23-12-6-7-14-26(23)32-28(33)25(17-19-9-4-3-5-10-19)22-13-8-11-20-15-16-21(27(30)31)18-24(20)22/h3-5,8-11,13,15-16,18,23,25-26H,2,6-7,12,14,17H2,1H3,(H3,30,31)(H,32,33)/t23-,25?,26+/m1/s1 BKHSHTISWVLYOB-XWYQMZBESA-N 12831 2,2,2-trifluoroacetic acid; ethyl (1R,2S)-2-[2-(7-carbamimidoylnaphthalen-1-yl)-3-phenylpropanamido]cyclohexane-1-carboxylate::7-amidinonaphthalene 40 Coagulation factor X Homo sapiens 530 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.045 10.7270/Q2K072H3 15582405 aid1796944 Qiao, JX; Cheng, X; Modi, DP; Rossi, KA; Luettgen, JM; Knabb, RM; Jadhav, PK; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12831&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646287 46513276 ZINC14951105 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23086 NCc1ccccc1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C25H18F4N6O2/c26-18-9-13(16-4-2-1-3-14(16)12-30)5-7-19(18)32-24(36)20-11-22(25(27,28)29)33-35(20)15-6-8-21-17(10-15)23(31)34-37-21/h1-11H,12,30H2,(H2,31,34)(H,32,36) NWOIJOGPQKSUCO-UHFFFAOYSA-N 12832 1-(3-amino-1,2-benzoxazol-5-yl)-N-{4-[2-(aminomethyl)phenyl]-2-fluorophenyl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2a Coagulation factor X Homo sapiens 2 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12832&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646288 46513277 ZINC14951108 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23087 CNCc1ccccc1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C26H20F4N6O2/c1-32-13-15-4-2-3-5-17(15)14-6-8-20(19(27)10-14)33-25(37)21-12-23(26(28,29)30)34-36(21)16-7-9-22-18(11-16)24(31)35-38-22/h2-12,32H,13H2,1H3,(H2,31,35)(H,33,37) IUCPGZLVLKJARS-UHFFFAOYSA-N 12833 1-(3-amino-1,2-benzoxazol-5-yl)-N-(2-fluoro-4-{2-[(methylamino)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2b Coagulation factor X Homo sapiens 0.27 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12833&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646289 46513278 ZINC01489805 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23088 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1CNCC1CC1)C(F)(F)F InChI=1S/C29H24F4N6O2/c30-22-11-17(20-4-2-1-3-18(20)15-35-14-16-5-6-16)7-9-23(22)36-28(40)24-13-26(29(31,32)33)37-39(24)19-8-10-25-21(12-19)27(34)38-41-25/h1-4,7-13,16,35H,5-6,14-15H2,(H2,34,38)(H,36,40) KXYCKYNUVARMMF-UHFFFAOYSA-N 12834 1-(3-amino-1,2-benzoxazol-5-yl)-N-[4-(2-{[(cyclopropylmethyl)amino]methyl}phenyl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2c Coagulation factor X Homo sapiens 0.25 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12834&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646290 46513279 ZINC14951113 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23089 CC(C)NCc1ccccc1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C28H24F4N6O2/c1-15(2)34-14-17-5-3-4-6-19(17)16-7-9-22(21(29)11-16)35-27(39)23-13-25(28(30,31)32)36-38(23)18-8-10-24-20(12-18)26(33)37-40-24/h3-13,15,34H,14H2,1-2H3,(H2,33,37)(H,35,39) BQUAXYUZCNMCEI-UHFFFAOYSA-N 12835 1-(3-amino-1,2-benzoxazol-5-yl)-N-(2-fluoro-4-{2-[(propan-2-ylamino)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2d Coagulation factor X Homo sapiens 0.34 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12835&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646291 46513280 ZINC14951119 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23090 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1CNC1CCC1)C(F)(F)F InChI=1S/C29H24F4N6O2/c30-22-12-16(20-7-2-1-4-17(20)15-35-18-5-3-6-18)8-10-23(22)36-28(40)24-14-26(29(31,32)33)37-39(24)19-9-11-25-21(13-19)27(34)38-41-25/h1-2,4,7-14,18,35H,3,5-6,15H2,(H2,34,38)(H,36,40) GNRCGBOCLCDMAC-UHFFFAOYSA-N 12836 1-(3-amino-1,2-benzoxazol-5-yl)-N-(4-{2-[(cyclobutylamino)methyl]phenyl}-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2e Coagulation factor X Homo sapiens 0.2 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12836&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646292 46513281 ZINC14951124 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23091 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1CNC1CCCC1)C(F)(F)F InChI=1S/C30H26F4N6O2/c31-23-13-17(21-8-4-1-5-18(21)16-36-19-6-2-3-7-19)9-11-24(23)37-29(41)25-15-27(30(32,33)34)38-40(25)20-10-12-26-22(14-20)28(35)39-42-26/h1,4-5,8-15,19,36H,2-3,6-7,16H2,(H2,35,39)(H,37,41) NQZNEYVHRSEFNX-UHFFFAOYSA-N 12837 1-(3-amino-1,2-benzoxazol-5-yl)-N-(4-{2-[(cyclopentylamino)methyl]phenyl}-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2f Coagulation factor X Homo sapiens 0.3 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12837&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646293 46513282 ZINC14951129 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23092 CN(C)Cc1ccccc1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C27H22F4N6O2/c1-36(2)14-16-5-3-4-6-18(16)15-7-9-21(20(28)11-15)33-26(38)22-13-24(27(29,30)31)34-37(22)17-8-10-23-19(12-17)25(32)35-39-23/h3-13H,14H2,1-2H3,(H2,32,35)(H,33,38) LDUWBIVGHVTDNA-UHFFFAOYSA-N 12688 1-(3-amino-1,2-benzoxazol-5-yl)-N-(4-{2-[(dimethylamino)methyl]phenyl}-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2g::BMS-740808 Analogue 15 Coagulation factor X Homo sapiens 0.21 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12688&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10143532 46513137 ZINC14950419 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23093 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1CN1CC1)C(F)(F)F InChI=1S/C27H20F4N6O2/c28-20-11-15(18-4-2-1-3-16(18)14-36-9-10-36)5-7-21(20)33-26(38)22-13-24(27(29,30)31)34-37(22)17-6-8-23-19(12-17)25(32)35-39-23/h1-8,11-13H,9-10,14H2,(H2,32,35)(H,33,38) SASAKMVEBSDLDN-UHFFFAOYSA-N 12839 1-(3-amino-1,2-benzoxazol-5-yl)-N-{4-[2-(aziridin-1-ylmethyl)phenyl]-2-fluorophenyl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2h Coagulation factor X Homo sapiens 0.4 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12839&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646294 46513283 ZINC14951136 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23094 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1CN1CCCC1)C(F)(F)F InChI=1S/C29H24F4N6O2/c30-22-13-17(20-6-2-1-5-18(20)16-38-11-3-4-12-38)7-9-23(22)35-28(40)24-15-26(29(31,32)33)36-39(24)19-8-10-25-21(14-19)27(34)37-41-25/h1-2,5-10,13-15H,3-4,11-12,16H2,(H2,34,37)(H,35,40) VWXAJELEKJVKSG-UHFFFAOYSA-N 12840 1-(3-amino-1,2-benzoxazol-5-yl)-N-{2-fluoro-4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2i Coagulation factor X Homo sapiens 0.1 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12840&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646295 46513284 ZINC14951142 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23095 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1CN1CCC[C@H]1CO)C(F)(F)F InChI=1S/C30H26F4N6O3/c31-23-12-17(21-6-2-1-4-18(21)15-39-11-3-5-20(39)16-41)7-9-24(23)36-29(42)25-14-27(30(32,33)34)37-40(25)19-8-10-26-22(13-19)28(35)38-43-26/h1-2,4,6-10,12-14,20,41H,3,5,11,15-16H2,(H2,35,38)(H,36,42)/t20-/m0/s1 HRFLXDHXKFKMKT-FQEVSTJZSA-N 12841 1-(3-amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-(2-{[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]methyl}phenyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2j Coagulation factor X Homo sapiens 0.2 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12841&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646296 46513285 ZINC14951149 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23096 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1CN1CC[C@@H](O)C1)C(F)(F)F InChI=1S/C29H24F4N6O3/c30-22-11-16(20-4-2-1-3-17(20)14-38-10-9-19(40)15-38)5-7-23(22)35-28(41)24-13-26(29(31,32)33)36-39(24)18-6-8-25-21(12-18)27(34)37-42-25/h1-8,11-13,19,40H,9-10,14-15H2,(H2,34,37)(H,35,41)/t19-/m1/s1 HQBRJIGJLJDFHY-LJQANCHMSA-N 12842 1-(3-amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2k Coagulation factor X Homo sapiens 0.16 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12842&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 15950345 46513286 ZINC14951156 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23097 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1CN1CC[C@H](O)C1)C(F)(F)F InChI=1S/C29H24F4N6O3/c30-22-11-16(20-4-2-1-3-17(20)14-38-10-9-19(40)15-38)5-7-23(22)35-28(41)24-13-26(29(31,32)33)36-39(24)18-6-8-25-21(12-18)27(34)37-42-25/h1-8,11-13,19,40H,9-10,14-15H2,(H2,34,37)(H,35,41)/t19-/m0/s1 HQBRJIGJLJDFHY-IBGZPJMESA-N 12843 1-(3-amino-1,2-benzoxazol-5-yl)-N-[2-fluoro-4-(2-{[(3S)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2l Coagulation factor X Homo sapiens 0.53 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12843&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646297 46513287 ZINC14951164 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23098 N[C@@H]1CCN(Cc2ccccc2-c2ccc(NC(=O)c3cc(nn3-c3ccc4onc(N)c4c3)C(F)(F)F)c(F)c2)C1 InChI=1S/C29H25F4N7O2/c30-22-11-16(20-4-2-1-3-17(20)14-39-10-9-18(34)15-39)5-7-23(22)36-28(41)24-13-26(29(31,32)33)37-40(24)19-6-8-25-21(12-19)27(35)38-42-25/h1-8,11-13,18H,9-10,14-15,34H2,(H2,35,38)(H,36,41)/t18-/m1/s1 YHIZCAWNRNQWMF-GOSISDBHSA-N 12844 1-(3-amino-1,2-benzoxazol-5-yl)-N-[4-(2-{[(3R)-3-aminopyrrolidin-1-yl]methyl}phenyl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2m Coagulation factor X Homo sapiens 0.52 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12844&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646298 46513288 ZINC23358206 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23099 N[C@H]1CCN(Cc2ccccc2-c2ccc(NC(=O)c3cc(nn3-c3ccc4onc(N)c4c3)C(F)(F)F)c(F)c2)C1 InChI=1S/C29H25F4N7O2/c30-22-11-16(20-4-2-1-3-17(20)14-39-10-9-18(34)15-39)5-7-23(22)36-28(41)24-13-26(29(31,32)33)37-40(24)19-6-8-25-21(12-19)27(35)38-42-25/h1-8,11-13,18H,9-10,14-15,34H2,(H2,35,38)(H,36,41)/t18-/m0/s1 YHIZCAWNRNQWMF-SFHVURJKSA-N 12845 1-(3-amino-1,2-benzoxazol-5-yl)-N-[4-(2-{[(3S)-3-aminopyrrolidin-1-yl]methyl}phenyl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2n Coagulation factor X Homo sapiens 0.54 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12845&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646299 46513289 ZINC23358210 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23100 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1CN1CCCCC1)C(F)(F)F InChI=1S/C30H26F4N6O2/c31-23-14-18(21-7-3-2-6-19(21)17-39-12-4-1-5-13-39)8-10-24(23)36-29(41)25-16-27(30(32,33)34)37-40(25)20-9-11-26-22(15-20)28(35)38-42-26/h2-3,6-11,14-16H,1,4-5,12-13,17H2,(H2,35,38)(H,36,41) JAMANIGSQMZMOS-UHFFFAOYSA-N 12846 1-(3-amino-1,2-benzoxazol-5-yl)-N-{2-fluoro-4-[2-(piperidin-1-ylmethyl)phenyl]phenyl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2o Coagulation factor X Homo sapiens 0.15 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12846&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646300 46513290 ZINC14951182 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23101 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1CN1CCOCC1)C(F)(F)F InChI=1S/C29H24F4N6O3/c30-22-13-17(20-4-2-1-3-18(20)16-38-9-11-41-12-10-38)5-7-23(22)35-28(40)24-15-26(29(31,32)33)36-39(24)19-6-8-25-21(14-19)27(34)37-42-25/h1-8,13-15H,9-12,16H2,(H2,34,37)(H,35,40) AIKLXWZOESUVBV-UHFFFAOYSA-N 12847 1-(3-amino-1,2-benzoxazol-5-yl)-N-{2-fluoro-4-[2-(morpholin-4-ylmethyl)phenyl]phenyl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2p Coagulation factor X Homo sapiens 0.55 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12847&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646301 46513291 ZINC14951189 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23102 CN1CCN(Cc2ccccc2-c2ccc(NC(=O)c3cc(nn3-c3ccc4onc(N)c4c3)C(F)(F)F)c(F)c2)CC1 InChI=1S/C30H27F4N7O2/c1-39-10-12-40(13-11-39)17-19-4-2-3-5-21(19)18-6-8-24(23(31)14-18)36-29(42)25-16-27(30(32,33)34)37-41(25)20-7-9-26-22(15-20)28(35)38-43-26/h2-9,14-16H,10-13,17H2,1H3,(H2,35,38)(H,36,42) KDZYVICPZRDOIO-UHFFFAOYSA-N 12848 1-(3-amino-1,2-benzoxazol-5-yl)-N-(2-fluoro-4-{2-[(4-methylpiperazin-1-yl)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2q Coagulation factor X Homo sapiens 0.86 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12848&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646302 46513292 ZINC23358213 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23103 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1CN1CCNCC1)C(F)(F)F InChI=1S/C29H25F4N7O2/c30-22-13-17(20-4-2-1-3-18(20)16-39-11-9-35-10-12-39)5-7-23(22)36-28(41)24-15-26(29(31,32)33)37-40(24)19-6-8-25-21(14-19)27(34)38-42-25/h1-8,13-15,35H,9-12,16H2,(H2,34,38)(H,36,41) HMOHJEKAKRIFLF-UHFFFAOYSA-N 12849 1-(3-amino-1,2-benzoxazol-5-yl)-N-{2-fluoro-4-[2-(piperazin-1-ylmethyl)phenyl]phenyl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2r Coagulation factor X Homo sapiens 1.14 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12849&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646303 46513293 ZINC22451845 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23104 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1Cn1ccnc1)C(F)(F)F InChI=1S/C28H19F4N7O2/c29-21-11-16(19-4-2-1-3-17(19)14-38-10-9-34-15-38)5-7-22(21)35-27(40)23-13-25(28(30,31)32)36-39(23)18-6-8-24-20(12-18)26(33)37-41-24/h1-13,15H,14H2,(H2,33,37)(H,35,40) ABNRVSUBULFNSQ-UHFFFAOYSA-N 12850 1-(3-amino-1,2-benzoxazol-5-yl)-N-{2-fluoro-4-[2-(1H-imidazol-1-ylmethyl)phenyl]phenyl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Aminobenzisoxazole 2s Coagulation factor X Homo sapiens 0.66 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12850&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23644672 46509406 ZINC14951201 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23105 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)Nc1ccc(cc1F)-c1ccccc1C[n+]1ccccc1)C(F)(F)F InChI=1S/C30H20F4N6O2/c31-23-14-18(21-7-3-2-6-19(21)17-39-12-4-1-5-13-39)8-10-24(23)36-29(41)25-16-27(30(32,33)34)37-40(25)20-9-11-26-22(15-20)28(35)38-42-26/h1-16H,17H2,(H2-,35,36,38,41)/p+1 LHGHEUKAZKXIJE-UHFFFAOYSA-O 12851 1-{[2-(4-{[1-(3-amino-1,2-benzoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-]amido}-3-fluorophenyl)phenyl]methyl}pyridin-1-ium bromide::Aminobenzisoxazole 2t Coagulation factor X Homo sapiens 0.08 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12851&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646305 46513294 ZINC14951208 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23106 C[N+]1(Cc2ccccc2-c2ccc(NC(=O)c3cc(nn3-c3ccc4onc(N)c4c3)C(F)(F)F)c(F)c2)CCOCC1 InChI=1S/C30H26F4N6O3/c1-40(10-12-42-13-11-40)17-19-4-2-3-5-21(19)18-6-8-24(23(31)14-18)36-29(41)25-16-27(30(32,33)34)37-39(25)20-7-9-26-22(15-20)28(35)38-43-26/h2-9,14-16H,10-13,17H2,1H3,(H2-,35,36,38,41)/p+1 YFYULXBYLCXBAP-UHFFFAOYSA-O 12852 4-{[2-(4-{[1-(3-amino-1,2-benzoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-]amido}-3-fluorophenyl)phenyl]methyl}-4-methylmorpholin-4-ium bromide::Aminobenzisoxazole 2u Coagulation factor X Homo sapiens 0.02 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12852&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646307 46513295 ZINC14951214 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23107 C[N+](C)(C)Cc1ccccc1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C28H24F4N6O2/c1-38(2,3)15-17-6-4-5-7-19(17)16-8-10-22(21(29)12-16)34-27(39)23-14-25(28(30,31)32)35-37(23)18-9-11-24-20(13-18)26(33)36-40-24/h4-14H,15H2,1-3H3,(H2-,33,34,36,39)/p+1 DJBYALCJSXJBHB-UHFFFAOYSA-O 12853 Aminobenzisoxazole 2v::{[2-(4-{[1-(3-amino-1,2-benzoxazol-5-yl)-3-(trifluoromethyl)-1H-pyrazole-5-]amido}-3-fluorophenyl)phenyl]methyl}trimethylazanium bromide Coagulation factor X Homo sapiens 0.05 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12853&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646309 46513296 ZINC14951221 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23108 CN(C)Cc1nccn1-c1ccc(NC(=O)c2cc(nn2-c2ccc3onc(N)c3c2)C(F)(F)F)c(F)c1 InChI=1S/C24H20F4N8O2/c1-34(2)12-21-30-7-8-35(21)13-3-5-17(16(25)10-13)31-23(37)18-11-20(24(26,27)28)32-36(18)14-4-6-19-15(9-14)22(29)33-38-19/h3-11H,12H2,1-2H3,(H2,29,33)(H,31,37) OFJRNBWSFXEHSA-UHFFFAOYSA-N 12676 1-(3-Aminobenzisoxazol-5-yl)-3-trifluoromethyl-N-[2-fluoro-4-[(2-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide Hydrochloride Salt::1-(3-amino-1,2-benzoxazol-5-yl)-N-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::BMS-561389::CHEMBL206335::CHEMBL558198::DPC 906::Razaxaban Coagulation factor X Homo sapiens 0.19 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.010 10.7270/Q2FB515N 16434195 aid1796951 Quan, ML; Han, Q; Fevig, JM; Lam, PY; Bai, S; Knabb, RM; Luettgen, JM; Wong, PC; Wexler, RR Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12676&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search IK8 1Z6E 204102 46513128 CHEMBL206335CHEMBL558198 ZINC03633839 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23109 CCOC(=O)c1nn(-c2ccc3onc(N)c3c2)c2c1ncn(-c1ccc(cc1)-c1ccccc1CN1CCCC1)c2=O InChI=1S/C32H29N7O4/c1-2-42-32(41)28-27-29(39(35-28)23-13-14-26-25(17-23)30(33)36-43-26)31(40)38(19-34-27)22-11-9-20(10-12-22)24-8-4-3-7-21(24)18-37-15-5-6-16-37/h3-4,7-14,17,19H,2,5-6,15-16,18H2,1H3,(H2,33,36) CRWZCCGACHVJJJ-UHFFFAOYSA-N 12854 Pyrazolo[4,3-d]pyrimidinone 12::ethyl 1-(3-amino-1,2-benzoxazol-5-yl)-7-oxo-6-{4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carboxylate Coagulation factor X Homo sapiens 1.6 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12854&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20760222 46513297 ZINC14951226 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23110 CN(C)Cc1ccccc1-c1ccc(cc1)-n1cnc2c(C)nn(-c3ccc4onc(N)c4c3)c2c1=O InChI=1S/C28H25N7O2/c1-17-25-26(35(31-17)21-12-13-24-23(14-21)27(29)32-37-24)28(36)34(16-30-25)20-10-8-18(9-11-20)22-7-5-4-6-19(22)15-33(2)3/h4-14,16H,15H2,1-3H3,(H2,29,32) CKBRNWVVQAJBLK-UHFFFAOYSA-N 12855 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-3-methyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Pyrazolo[4,3-d]pyrimidinone 19a Coagulation factor X Homo sapiens 0.53 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12855&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086972 46513298 ZINC14951232 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23111 Cc1nn(-c2ccc3onc(N)c3c2)c2c1ncn(-c1ccc(cc1)-c1ccccc1CN1CCCC1)c2=O InChI=1S/C30H27N7O2/c1-19-27-28(37(33-19)23-12-13-26-25(16-23)29(31)34-39-26)30(38)36(18-32-27)22-10-8-20(9-11-22)24-7-3-2-6-21(24)17-35-14-4-5-15-35/h2-3,6-13,16,18H,4-5,14-15,17H2,1H3,(H2,31,34) SWXKZPXOCFIGGY-UHFFFAOYSA-N 12856 1-(3-amino-1,2-benzoxazol-5-yl)-3-methyl-6-{4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Pyrazolo[4,3-d]pyrimidinone 19b Coagulation factor X Homo sapiens 1.3 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12856&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086987 46513299 ZINC14951236 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23112 Cc1nn(-c2ccc3onc(N)c3c2)c2c1ncn(-c1ccc(cc1)-c1ccccc1CN1CC[C@H](O)C1)c2=O InChI=1S/C30H27N7O3/c1-18-27-28(37(33-18)22-10-11-26-25(14-22)29(31)34-40-26)30(39)36(17-32-27)21-8-6-19(7-9-21)24-5-3-2-4-20(24)15-35-13-12-23(38)16-35/h2-11,14,17,23,38H,12-13,15-16H2,1H3,(H2,31,34)/t23-/m0/s1 MZTLUQWQCIFDEZ-QHCPKHFHSA-N 12857 1-(3-amino-1,2-benzoxazol-5-yl)-6-[4-(2-{[(3S)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-3-methyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Pyrazolo[4,3-d]pyrimidinone 19c Coagulation factor X Homo sapiens 0.5 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12857&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646310 46513300 ZINC14951242 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23113 Cc1nn(-c2ccc3onc(N)c3c2)c2c1ncn(-c1ccc(cc1)-c1ccccc1CNCC1CC1)c2=O InChI=1S/C30H27N7O2/c1-18-27-28(37(34-18)23-12-13-26-25(14-23)29(31)35-39-26)30(38)36(17-33-27)22-10-8-20(9-11-22)24-5-3-2-4-21(24)16-32-15-19-6-7-19/h2-5,8-14,17,19,32H,6-7,15-16H2,1H3,(H2,31,35) TUVAXWSWGJUIGN-UHFFFAOYSA-N 12858 1-(3-amino-1,2-benzoxazol-5-yl)-6-[4-(2-{[(cyclopropylmethyl)amino]methyl}phenyl)phenyl]-3-methyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Pyrazolo[4,3-d]pyrimidinone 19d Coagulation factor X Homo sapiens 1.7 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12858&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086968 46513301 ZINC14951246 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23114 CC(C)NCc1ccccc1-c1ccc(cc1)-n1cnc2c(C)nn(-c3ccc4onc(N)c4c3)c2c1=O InChI=1S/C29H27N7O2/c1-17(2)31-15-20-6-4-5-7-23(20)19-8-10-21(11-9-19)35-16-32-26-18(3)33-36(27(26)29(35)37)22-12-13-25-24(14-22)28(30)34-38-25/h4-14,16-17,31H,15H2,1-3H3,(H2,30,34) FPAAVCQGCYUBJA-UHFFFAOYSA-N 12859 1-(3-amino-1,2-benzoxazol-5-yl)-3-methyl-6-(4-{2-[(propan-2-ylamino)methyl]phenyl}phenyl)-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Pyrazolo[4,3-d]pyrimidinone 19e Coagulation factor X Homo sapiens 1.5 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12859&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086978 46513302 ZINC14951252 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23115 CN(C)Cc1ccccc1-c1ccc(cc1)-n1c(C)nc2c(C)nn(-c3ccc4onc(N)c4c3)c2c1=O InChI=1S/C29H27N7O2/c1-17-26-27(36(32-17)22-13-14-25-24(15-22)28(30)33-38-25)29(37)35(18(2)31-26)21-11-9-19(10-12-21)23-8-6-5-7-20(23)16-34(3)4/h5-15H,16H2,1-4H3,(H2,30,33) HSCKUOWMBQOWFF-UHFFFAOYSA-N 12860 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-3,5-dimethyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Pyrazolo[4,3-d]pyrimidinone 19f Coagulation factor X Homo sapiens 0.27 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12860&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16046152 46513303 ZINC14951257 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23116 Cc1nn(-c2ccc3onc(N)c3c2)c2c1nc(C)n(-c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)c2=O InChI=1S/C31H29N7O3/c1-18-28-29(38(34-18)23-11-12-27-26(15-23)30(32)35-41-27)31(40)37(19(2)33-28)22-9-7-20(8-10-22)25-6-4-3-5-21(25)16-36-14-13-24(39)17-36/h3-12,15,24,39H,13-14,16-17H2,1-2H3,(H2,32,35)/t24-/m1/s1 POCPCDOLJIBGGA-XMMPIXPASA-N 12861 1-(3-amino-1,2-benzoxazol-5-yl)-6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-3,5-dimethyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Pyrazolo[4,3-d]pyrimidinone 19g Coagulation factor X Homo sapiens 0.37 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12861&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16046153 46513304 ZINC14951263 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23117 CC(C)N(C)Cc1ccccc1-c1ccc(cc1)-n1c(C)nc2c(C)nn(-c3ccc4onc(N)c4c3)c2c1=O InChI=1S/C31H31N7O2/c1-18(2)36(5)17-22-8-6-7-9-25(22)21-10-12-23(13-11-21)37-20(4)33-28-19(3)34-38(29(28)31(37)39)24-14-15-27-26(16-24)30(32)35-40-27/h6-16,18H,17H2,1-5H3,(H2,32,35) KLMPGRJKGKGQNY-UHFFFAOYSA-N 12862 1-(3-amino-1,2-benzoxazol-5-yl)-3,5-dimethyl-6-[4-(2-{[methyl(propan-2-yl)amino]methyl}phenyl)phenyl]-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Pyrazolo[4,3-d]pyrimidinone 19h Coagulation factor X Homo sapiens 0.35 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12862&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646311 46513305 ZINC14951269 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23118 CN(C)Cc1ccccc1-c1ccc(cc1)-n1cnc2c(nn(-c3ccc4onc(N)c4c3)c2c1=O)C(F)(F)F InChI=1S/C28H22F3N7O2/c1-36(2)14-17-5-3-4-6-20(17)16-7-9-18(10-8-16)37-15-33-23-24(27(37)39)38(34-25(23)28(29,30)31)19-11-12-22-21(13-19)26(32)35-40-22/h3-13,15H,14H2,1-2H3,(H2,32,35) SJZACGUSACJVDL-UHFFFAOYSA-N 12863 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Pyrazolo[4,3-d]pyrimidinone 23a Coagulation factor X Homo sapiens 0.35 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12863&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086974 46513306 ZINC01490567 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23119 CN(C)Cc1ccccc1-c1ccc(cc1)-n1c(C)nc2c(nn(-c3ccc4onc(N)c4c3)c2c1=O)C(F)(F)F InChI=1S/C29H24F3N7O2/c1-16-34-24-25(39(35-26(24)29(30,31)32)20-12-13-23-22(14-20)27(33)36-41-23)28(40)38(16)19-10-8-17(9-11-19)21-7-5-4-6-18(21)15-37(2)3/h4-14H,15H2,1-3H3,(H2,33,36) LUFLMQPOYZXEPI-UHFFFAOYSA-N 12864 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-5-methyl-3-(trifluoromethyl)-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Pyrazolo[4,3-d]pyrimidinone 23b Coagulation factor X Homo sapiens 0.17 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12864&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646312 46513307 ZINC14210483 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23120 Cc1nc2c(nn(-c3ccc4onc(N)c4c3)c2c(=O)n1-c1ccc(cc1)-c1ccccc1CNCC1CC1)C(F)(F)F InChI=1S/C31H26F3N7O2/c1-17-37-26-27(41(38-28(26)31(32,33)34)22-12-13-25-24(14-22)29(35)39-43-25)30(42)40(17)21-10-8-19(9-11-21)23-5-3-2-4-20(23)16-36-15-18-6-7-18/h2-5,8-14,18,36H,6-7,15-16H2,1H3,(H2,35,39) IMHADQMMGOEFNC-UHFFFAOYSA-N 12865 1-(3-amino-1,2-benzoxazol-5-yl)-6-[4-(2-{[(cyclopropylmethyl)amino]methyl}phenyl)phenyl]-5-methyl-3-(trifluoromethyl)-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Pyrazolo[4,3-d]pyrimidinone 23c Coagulation factor X Homo sapiens 0.5 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12865&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646313 46513308 ZINC14951275 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23121 Cc1nc2c(nn(-c3ccc4onc(N)c4c3)c2c(=O)n1-c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)C(F)(F)F InChI=1S/C31H26F3N7O3/c1-17-36-26-27(41(37-28(26)31(32,33)34)21-10-11-25-24(14-21)29(35)38-44-25)30(43)40(17)20-8-6-18(7-9-20)23-5-3-2-4-19(23)15-39-13-12-22(42)16-39/h2-11,14,22,42H,12-13,15-16H2,1H3,(H2,35,38)/t22-/m1/s1 XDCVKLLWXSIRHC-JOCHJYFZSA-N 12866 1-(3-amino-1,2-benzoxazol-5-yl)-6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-5-methyl-3-(trifluoromethyl)-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Pyrazolo[4,3-d]pyrimidinone 23d Coagulation factor X Homo sapiens 0.18 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12866&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646314 46513309 ZINC14951281 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23122 CN(C)Cc1ccccc1-c1ccc(cc1)N1CNc2c(nn(c2C1=O)-c1ccc2onc(N)c2c1)C(F)(F)F InChI=1S/C28H24F3N7O2/c1-36(2)14-17-5-3-4-6-20(17)16-7-9-18(10-8-16)37-15-33-23-24(27(37)39)38(34-25(23)28(29,30)31)19-11-12-22-21(13-19)26(32)35-40-22/h3-13,33H,14-15H2,1-2H3,(H2,32,35) WNKVDNSACGSTII-UHFFFAOYSA-N 12687 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::BMS-740808 Analogue 18::dihydropyrazolo[4,3-d]pyrimidinone 24a Coagulation factor X Homo sapiens 0.25 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12687&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22086975 46513136 ZINC14950416 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23123 Nc1noc2ccc(cc12)-n1nc(c2NCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)C(F)(F)F InChI=1S/C30H26F3N7O3/c31-30(32,33)27-25-26(40(36-27)20-9-10-24-23(13-20)28(34)37-43-24)29(42)39(16-35-25)19-7-5-17(6-8-19)22-4-2-1-3-18(22)14-38-12-11-21(41)15-38/h1-10,13,21,35,41H,11-12,14-16H2,(H2,34,37)/t21-/m1/s1 KWXHTGARBNTADQ-OAQYLSRUSA-N 12868 1-(3-amino-1,2-benzoxazol-5-yl)-6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::dihydropyrazolo[4,3-d]pyrimidinone 24b Coagulation factor X Homo sapiens 0.21 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12868&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646315 46513310 ZINC14951288 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23124 CN(C)Cc1nccn1-c1ccc(c(F)c1)-n1c(=O)[nH]c2c(nn(-c3ccc4onc(N)c4c3)c2c1=O)C(F)(F)F InChI=1S/C25H19F4N9O3/c1-35(2)11-18-31-7-8-36(18)12-3-5-16(15(26)10-12)37-23(39)20-19(32-24(37)40)21(25(27,28)29)33-38(20)13-4-6-17-14(9-13)22(30)34-41-17/h3-10H,11H2,1-2H3,(H2,30,34)(H,32,40) RLHFVSLDOHVUEA-UHFFFAOYSA-N 12869 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]-1H-imidazol-1-yl}-2-fluorophenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-d]pyrimidine-5,7-dione::pyrazolo[4,3-d]pyrimidindione 26a Coagulation factor X Homo sapiens 0.35 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12869&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646316 46513311 ZINC14951293 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23125 Nc1noc2ccc(cc12)-n1nc(c2[nH]c(=O)n(-c3ccc(cc3)-c3ccccc3CN3CC[C@@H](O)C3)c(=O)c12)C(F)(F)F InChI=1S/C30H24F3N7O4/c31-30(32,33)26-24-25(40(36-26)19-9-10-23-22(13-19)27(34)37-44-23)28(42)39(29(43)35-24)18-7-5-16(6-8-18)21-4-2-1-3-17(21)14-38-12-11-20(41)15-38/h1-10,13,20,41H,11-12,14-15H2,(H2,34,37)(H,35,43)/t20-/m1/s1 TWMNBFIQJQJQJW-HXUWFJFHSA-N 12870 1-(3-amino-1,2-benzoxazol-5-yl)-6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-d]pyrimidine-5,7-dione::pyrazolo[4,3-d]pyrimidindione 26b Coagulation factor X Homo sapiens 0.11 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12870&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646317 46513312 ZINC14951298 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23126 Nc1noc2ccc(cc12)-n1nc(c2[nH]c(=O)n(-c3ccc(cc3)-c3ccccc3CN3CCC(O)CC3)c(=O)c12)C(F)(F)F InChI=1S/C31H26F3N7O4/c32-31(33,34)27-25-26(41(37-27)20-9-10-24-23(15-20)28(35)38-45-24)29(43)40(30(44)36-25)19-7-5-17(6-8-19)22-4-2-1-3-18(22)16-39-13-11-21(42)12-14-39/h1-10,15,21,42H,11-14,16H2,(H2,35,38)(H,36,44) VIIILDBFJJEGDZ-UHFFFAOYSA-N 12871 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(4-hydroxypiperidin-1-yl)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-d]pyrimidine-5,7-dione::pyrazolo[4,3-d]pyrimidindione 26c Coagulation factor X Homo sapiens 0.22 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12871&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646318 46513313 ZINC14951305 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23127 CN(C)Cc1ccccc1-c1ccc(cc1)-c1cnc2c(nn(-c3ccc4onc(N)c4c3)c2c1O)C(F)(F)F InChI=1S/C29H23F3N6O2/c1-37(2)15-18-5-3-4-6-20(18)16-7-9-17(10-8-16)22-14-34-24-25(26(22)39)38(35-27(24)29(30,31)32)19-11-12-23-21(13-19)28(33)36-40-23/h3-14H,15H2,1-2H3,(H2,33,36)(H,34,39) MHUDSSWPYCLMLR-UHFFFAOYSA-N 12872 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,4H,7H-pyrazolo[4,3-b]pyridin-7-one::pyrazolo[4,3-b]pyridinone 26d Coagulation factor X Homo sapiens 3.2 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12872&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646319 46513314 ZINC14951308 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23128 Nc1noc2ccc(cc12)-n1nc(c2nc(N)c(-c3ccc(cc3)-c3ccccc3CN3CCC(O)CC3)c(O)c12)C(F)(F)F InChI=1S/C32H28F3N7O3/c33-32(34,35)29-26-27(42(39-29)20-9-10-24-23(15-20)30(36)40-45-24)28(44)25(31(37)38-26)18-7-5-17(6-8-18)22-4-2-1-3-19(22)16-41-13-11-21(43)12-14-41/h1-10,15,21,43H,11-14,16H2,(H2,36,40)(H3,37,38,44) JKTNGLROJHNUKW-UHFFFAOYSA-N 12873 5-amino-1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(4-hydroxypiperidin-1-yl)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,4H,7H-pyrazolo[4,3-b]pyridin-7-one::pyrazolo[4,3-b]pyridinone 26e Coagulation factor X Homo sapiens 0.77 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12873&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646320 46513315 ZINC14951313 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23129 CN(C)Cc1ccccc1-c1ccc(cc1)-c1nnc2c(nn(-c3ccc4onc(N)c4c3)c2c1O)C(F)(F)F InChI=1S/C28H22F3N7O2/c1-37(2)14-17-5-3-4-6-19(17)15-7-9-16(10-8-15)22-25(39)24-23(34-33-22)26(28(29,30)31)35-38(24)18-11-12-21-20(13-18)27(32)36-40-21/h3-13H,14H2,1-2H3,(H2,32,36)(H,34,39) IHADKCDCROVAKF-UHFFFAOYSA-N 12874 1-(3-amino-1,2-benzoxazol-5-yl)-6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-3-(trifluoromethyl)-1H,4H,7H-pyrazolo[4,3-c]pyridazin-7-one::pyrazolo[4,3-c]pyridazinone 26f Coagulation factor X Homo sapiens 5.5 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.07.002 10.7270/Q29K48GC 16870435 aid1796952 Li, YL; Fevig, JM; Cacciola, J; Buriak, J; Rossi, KA; Jona, J; Knabb, RM; Luettgen, JM; Wong, PC; Bai, SA; Wexler, RR; Lam, PY Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12874&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11497599 46513316 ZINC14951318 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24369 COc1cc(ccc1OCc1ccccc1)[C@@H](Nc1ccc(cc1)C(N)=N)C(=O)N[C@H](C(O)=O)c1ccccc1 InChI=1S/C31H30N4O5/c1-39-26-18-23(14-17-25(26)40-19-20-8-4-2-5-9-20)27(34-24-15-12-22(13-16-24)29(32)33)30(36)35-28(31(37)38)21-10-6-3-7-11-21/h2-18,27-28,34H,19H2,1H3,(H3,32,33)(H,35,36)(H,37,38)/t27-,28+/m1/s1 WGEGXJPYFSZDMU-IZLXSDGUSA-N 13552 (2S)-2-[(2R)-2-[4-(benzyloxy)-3-methoxyphenyl]-2-[(4-carbamimidoylphenyl)amino]acetamido]-2-phenylacetic acid::phenylglycine amide compound 9::phenylglycine deriv. 1 Coagulation factor X Homo sapiens 8000 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13552&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 413 1W7X,1W8B 5287506 46513953 ZINC03932449 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24370 COc1cc(C(Nc2ccc(cc2)C(N)=N)C(=O)N[C@H](C(O)=O)c2ccccc2)c(cc1OCc1ccccc1)S(=O)(=O)c1ccccc1 InChI=1S/C37H34N4O7S/c1-47-30-21-29(32(49(45,46)28-15-9-4-10-16-28)22-31(30)48-23-24-11-5-2-6-12-24)34(40-27-19-17-26(18-20-27)35(38)39)36(42)41-33(37(43)44)25-13-7-3-8-14-25/h2-22,33-34,40H,23H2,1H3,(H3,38,39)(H,41,42)(H,43,44)/t33-,34?/m0/s1 VMAJIKJVRRFMIB-CDRRMRQFSA-N 13554 (2S)-2-{2-[2-(benzenesulfonyl)-4-(benzyloxy)-5-methoxyphenyl]-2-[(4-carbamimidoylphenyl)amino]acetamido}-2-phenylacetic acid::phenylglycine amide compound 10::phenylglycine deriv. 2 Coagulation factor X Homo sapiens 12400 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13554&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11250964 46513954 ZINC96210455 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24371 COc1cc(C(Nc2ccc(cc2)C(N)=N)C(=O)N[C@H](C(O)=O)c2ccccc2)c(cc1OCc1ccccc1)C(=O)Cc1ccccc1 InChI=1S/C39H36N4O6/c1-48-33-23-31(30(32(44)21-25-11-5-2-6-12-25)22-34(33)49-24-26-13-7-3-8-14-26)36(42-29-19-17-28(18-20-29)37(40)41)38(45)43-35(39(46)47)27-15-9-4-10-16-27/h2-20,22-23,35-36,42H,21,24H2,1H3,(H3,40,41)(H,43,45)(H,46,47)/t35-,36?/m0/s1 VTMDRMAPYBSBFM-TYIYNAFKSA-N 13555 (2S)-2-{2-[4-(benzyloxy)-5-methoxy-2-(2-phenylacetyl)phenyl]-2-[(4-carbamimidoylphenyl)amino]acetamido}-2-phenylacetic acid::phenylglycine amide compound 11::phenylglycine deriv. 3 Coagulation factor X Homo sapiens 19000 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13555&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11411220 46513955 ZINC96210456 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24372 COc1cc(ccc1OCc1ccccc1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C23H23N3O4/c1-29-20-13-17(9-12-19(20)30-14-15-5-3-2-4-6-15)21(23(27)28)26-18-10-7-16(8-11-18)22(24)25/h2-13,21,26H,14H2,1H3,(H3,24,25)(H,27,28) OBEJFOHWQWJNIL-UHFFFAOYSA-N 13556 2-[4-(benzyloxy)-3-methoxyphenyl]-2-[(4-carbamimidoylphenyl)amino]acetic acid::phenylglycine deriv. 4 Coagulation factor X Homo sapiens 730 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13556&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22039255 46513956 ZINC13916739 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24373 CCOc1cc(ccc1OCc1ccccc1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C24H25N3O4/c1-2-30-21-14-18(10-13-20(21)31-15-16-6-4-3-5-7-16)22(24(28)29)27-19-11-8-17(9-12-19)23(25)26/h3-14,22,27H,2,15H2,1H3,(H3,25,26)(H,28,29) MMBMCZFUAWRURS-UHFFFAOYSA-N 13557 2-[4-(benzyloxy)-3-ethoxyphenyl]-2-[(4-carbamimidoylphenyl)amino]acetic acid::phenylglycine deriv. 5 Coagulation factor X Homo sapiens 790 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13557&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22039455 46513957 ZINC14953221 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24374 CCOc1cc(OCC)cc(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C19H23N3O4/c1-3-25-15-9-13(10-16(11-15)26-4-2)17(19(23)24)22-14-7-5-12(6-8-14)18(20)21/h5-11,17,22H,3-4H2,1-2H3,(H3,20,21)(H,23,24) UXQFXLBBPPHNHB-UHFFFAOYSA-N 13558 2-[(4-carbamimidoylphenyl)amino]-2-(3,5-diethoxyphenyl)acetic acid::phenylglycine deriv. 6::phenylglycine derivative 1 Coagulation factor X Homo sapiens 5600 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13558&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646453 46513958 ZINC14953231 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24375 CCOc1cc(OC2CCOCC2)cc(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C22H27N3O5/c1-2-29-18-11-15(12-19(13-18)30-17-7-9-28-10-8-17)20(22(26)27)25-16-5-3-14(4-6-16)21(23)24/h3-6,11-13,17,20,25H,2,7-10H2,1H3,(H3,23,24)(H,26,27) CVVVPWCOCJSPHV-UHFFFAOYSA-N 13559 2-[(4-carbamimidoylphenyl)amino]-2-[3-ethoxy-5-(oxan-4-yloxy)phenyl]acetic acid::phenylglycine deriv. 7 Coagulation factor X Homo sapiens 2900 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13559&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9931543 46513959 ZINC14953240 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24376 CCc1cc(OC2CCOCC2)cc(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C22H27N3O4/c1-2-14-11-16(13-19(12-14)29-18-7-9-28-10-8-18)20(22(26)27)25-17-5-3-15(4-6-17)21(23)24/h3-6,11-13,18,20,25H,2,7-10H2,1H3,(H3,23,24)(H,26,27) MYPLUXKPUNFOLX-UHFFFAOYSA-N 13560 2-[(4-carbamimidoylphenyl)amino]-2-[3-ethyl-5-(oxan-4-yloxy)phenyl]acetic acid::phenylglycine deriv. 8 Coagulation factor X Homo sapiens >7500 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13560&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22038750 46513960 ZINC14953251 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24377 NC(=N)c1ccc(NC(C(O)=O)c2cc(OC3CCOCC3)cc(C=C)c2)cc1 InChI=1S/C22H25N3O4/c1-2-14-11-16(13-19(12-14)29-18-7-9-28-10-8-18)20(22(26)27)25-17-5-3-15(4-6-17)21(23)24/h2-6,11-13,18,20,25H,1,7-10H2,(H3,23,24)(H,26,27) HHOFEOWBKYQOPC-UHFFFAOYSA-N 13561 2-[(4-carbamimidoylphenyl)amino]-2-[3-ethenyl-5-(oxan-4-yloxy)phenyl]acetic acid::phenylglycine deriv. 9 Coagulation factor X Homo sapiens 13300 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13561&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646454 46513961 ZINC14953264 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24378 NC(=N)c1ccc(NC(C(O)=O)c2cc(OC3CCOCC3)cc(c2)C#C)cc1 InChI=1S/C22H23N3O4/c1-2-14-11-16(13-19(12-14)29-18-7-9-28-10-8-18)20(22(26)27)25-17-5-3-15(4-6-17)21(23)24/h1,3-6,11-13,18,20,25H,7-10H2,(H3,23,24)(H,26,27) ZWQVDURIYFGIDM-UHFFFAOYSA-N 13562 2-[(4-carbamimidoylphenyl)amino]-2-[3-ethynyl-5-(oxan-4-yloxy)phenyl]acetic acid::phenylglycine deriv. 10 Coagulation factor X Homo sapiens 2900 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13562&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11538422 46513962 ZINC14953274 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24379 CCOc1cc(O[C@H]2CC[C@H](O)CC2)cc(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C23H29N3O5/c1-2-30-19-11-15(12-20(13-19)31-18-9-7-17(27)8-10-18)21(23(28)29)26-16-5-3-14(4-6-16)22(24)25/h3-6,11-13,17-18,21,26-27H,2,7-10H2,1H3,(H3,24,25)(H,28,29)/t17-,18-,21? DEGRHQBKZOASMX-MKAMJTKASA-N 13563 2-[(4-carbamimidoylphenyl)amino]-2-{3-ethoxy-5-[(4-hydroxycyclohexyl)oxy]phenyl}acetic acid::phenylglycine deriv. 11 Coagulation factor X Homo sapiens 12200 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13563&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22038873 46513963 ZINC14953284 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24380 CCOc1cc(OC2CCN(CC2)S(C)(=O)=O)cc(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C23H30N4O6S/c1-3-32-19-12-16(21(23(28)29)26-17-6-4-15(5-7-17)22(24)25)13-20(14-19)33-18-8-10-27(11-9-18)34(2,30)31/h4-7,12-14,18,21,26H,3,8-11H2,1-2H3,(H3,24,25)(H,28,29) MYXDQJCUFNEXCT-UHFFFAOYSA-N 13564 2-[(4-carbamimidoylphenyl)amino]-2-{3-ethoxy-5-[(1-methanesulfonylpiperidin-4-yl)oxy]phenyl}acetic acid::phenylglycine deriv. 12 Coagulation factor X Homo sapiens 4400 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13564&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9891759 46513964 ZINC14953294 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24381 CCOc1cc(OC2CCN(C)CC2)cc(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C23H30N4O4/c1-3-30-19-12-16(13-20(14-19)31-18-8-10-27(2)11-9-18)21(23(28)29)26-17-6-4-15(5-7-17)22(24)25/h4-7,12-14,18,21,26H,3,8-11H2,1-2H3,(H3,24,25)(H,28,29) OVMVSMLTWVJHCN-UHFFFAOYSA-N 13565 2-[(4-carbamimidoylphenyl)amino]-2-{3-ethoxy-5-[(1-methylpiperidin-4-yl)oxy]phenyl}acetic acid::phenylglycine deriv. 13 Coagulation factor X Homo sapiens 1600 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13565&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9823789 46513965 ZINC14953304 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24382 CCOc1cc(O[C@H]2CCOC2)cc(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C21H25N3O5/c1-2-28-17-9-14(10-18(11-17)29-16-7-8-27-12-16)19(21(25)26)24-15-5-3-13(4-6-15)20(22)23/h3-6,9-11,16,19,24H,2,7-8,12H2,1H3,(H3,22,23)(H,25,26)/t16-,19?/m0/s1 ZKEPSHHZWYCVRH-UCFFOFKASA-N 13566 2-[(4-carbamimidoylphenyl)amino]-2-{3-ethoxy-5-[(3S)-oxolan-3-yloxy]phenyl}acetic acid::phenylglycine deriv. 14 Coagulation factor X Homo sapiens 2300 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13566&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646455 46513966 ZINC14953313 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24383 NC(=N)c1ccc(NC(C(O)=O)c2cc(O[C@H]3CCOC3)cc(c2)C#C)cc1 InChI=1S/C21H21N3O4/c1-2-13-9-15(11-18(10-13)28-17-7-8-27-12-17)19(21(25)26)24-16-5-3-14(4-6-16)20(22)23/h1,3-6,9-11,17,19,24H,7-8,12H2,(H3,22,23)(H,25,26)/t17-,19?/m0/s1 VMITUNZSHSJLHI-KKFHFHRHSA-N 13567 2-[(4-carbamimidoylphenyl)amino]-2-{3-ethynyl-5-[(3S)-oxolan-3-yloxy]phenyl}acetic acid::phenylglycine deriv. 15 Coagulation factor X Homo sapiens 2600 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13567&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646456 46513967 ZINC14953322 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24384 CCOc1cc(O[C@@H]2CCOC2)cc(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C21H25N3O5/c1-2-28-17-9-14(10-18(11-17)29-16-7-8-27-12-16)19(21(25)26)24-15-5-3-13(4-6-15)20(22)23/h3-6,9-11,16,19,24H,2,7-8,12H2,1H3,(H3,22,23)(H,25,26)/t16-,19?/m1/s1 ZKEPSHHZWYCVRH-VTBWFHPJSA-N 13568 2-[(4-carbamimidoylphenyl)amino]-2-{3-ethoxy-5-[(3R)-oxolan-3-yloxy]phenyl}acetic acid::phenylglycine deriv. 16 Coagulation factor X Homo sapiens 9100 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13568&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646457 46513968 ZINC14953331 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24385 NC(=N)c1ccc(NC(C(O)=O)c2cc(O[C@@H]3CCOC3)cc(c2)C#C)cc1 InChI=1S/C21H21N3O4/c1-2-13-9-15(11-18(10-13)28-17-7-8-27-12-17)19(21(25)26)24-16-5-3-14(4-6-16)20(22)23/h1,3-6,9-11,17,19,24H,7-8,12H2,(H3,22,23)(H,25,26)/t17-,19?/m1/s1 VMITUNZSHSJLHI-DUSLRRAJSA-N 13569 2-[(4-carbamimidoylphenyl)amino]-2-{3-ethynyl-5-[(3R)-oxolan-3-yloxy]phenyl}acetic acid::phenylglycine deriv. 17 Coagulation factor X Homo sapiens 15300 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13569&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646458 46513969 ZINC14953340 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24386 CCOc1cc(O[C@H]2CCOC2)cc(c1)[C@@H](Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C21H25N3O5/c1-2-28-17-9-14(10-18(11-17)29-16-7-8-27-12-16)19(21(25)26)24-15-5-3-13(4-6-15)20(22)23/h3-6,9-11,16,19,24H,2,7-8,12H2,1H3,(H3,22,23)(H,25,26)/t16-,19+/m0/s1 ZKEPSHHZWYCVRH-QFBILLFUSA-N 13570 (2R)-2-[(4-carbamimidoylphenyl)amino]-2-{3-ethoxy-5-[(3S)-oxolan-3-yloxy]phenyl}acetic acid::phenylglycine deriv. 18 Coagulation factor X Homo sapiens 1500 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13570&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646459 46513970 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24387 CCOc1cc(cc(c1)-c1ccccc1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C23H23N3O3/c1-2-29-20-13-17(15-6-4-3-5-7-15)12-18(14-20)21(23(27)28)26-19-10-8-16(9-11-19)22(24)25/h3-14,21,26H,2H2,1H3,(H3,24,25)(H,27,28) HCKRPPGEUVWKLE-UHFFFAOYSA-N 13571 2-[(4-carbamimidoylphenyl)amino]-2-(3-ethoxy-5-phenylphenyl)acetic acid::phenylglycine deriv. 19 Coagulation factor X Homo sapiens 1400 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13571&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22039678 46513971 ZINC14953351 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24388 CCOc1cc(cc(c1)-c1cccnc1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C22H22N4O3/c1-2-29-19-11-16(15-4-3-9-25-13-15)10-17(12-19)20(22(27)28)26-18-7-5-14(6-8-18)21(23)24/h3-13,20,26H,2H2,1H3,(H3,23,24)(H,27,28) BIORCEZFBREAOO-UHFFFAOYSA-N 13572 2-[(4-carbamimidoylphenyl)amino]-2-[3-ethoxy-5-(pyridin-3-yl)phenyl]acetic acid::phenylglycine deriv. 20 Coagulation factor X Homo sapiens 2200 Curated from the literature by BindingDB 10.1016/j.bmcl.2005.04.079 10.7270/Q2X63K6X 16213138 aid1797057 Zbinden, KG; Obst-Sander, U; Hilpert, K; Kuhne, H; Banner, DW; Bohm, HJ; Stahl, M; Ackermann, J; Alig, L; Weber, L; Wessel, HP; Riederer, MA; Tschopp, TB; Lave, T F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13572&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646460 46513972 ZINC14953360 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24431 COc1ccc(cc1OC)C(Nc1ccc(cc1)C(N)=N)C(=O)NCc1ccccc1 InChI=1S/C24H26N4O3/c1-30-20-13-10-18(14-21(20)31-2)22(24(29)27-15-16-6-4-3-5-7-16)28-19-11-8-17(9-12-19)23(25)26/h3-14,22,28H,15H2,1-2H3,(H3,25,26)(H,27,29) BMQMRSICTKGCCO-UHFFFAOYSA-N 13575 N-benzyl-2-[(4-carbamimidoylphenyl)amino]-2-(3,4-dimethoxyphenyl)acetamide::phenylglycine amide compound 1 Coagulation factor X Homo sapiens 30000 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.092 10.7270/Q2SF2TFR 15664864 aid1797062 Groebke Zbinden, K; Banner, DW; Ackermann, J; D'Arcy, A; Kirchhofer, D; Ji, YH; Tschopp, TB; Wallbaum, S; Weber, L F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13575&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 380 1W2K 23283331 46513973 ZINC14953364 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24432 CCOc1ccc(cc1OCC)C(Nc1ccc(cc1)C(N)=N)C(=O)NCc1ccccc1 InChI=1S/C26H30N4O3/c1-3-32-22-15-12-20(16-23(22)33-4-2)24(26(31)29-17-18-8-6-5-7-9-18)30-21-13-10-19(11-14-21)25(27)28/h5-16,24,30H,3-4,17H2,1-2H3,(H3,27,28)(H,29,31) UNPGSBXHFNJKSN-UHFFFAOYSA-N 13576 N-benzyl-2-[(4-carbamimidoylphenyl)amino]-2-(3,4-diethoxyphenyl)acetamide::phenylglycine amide compound 2 Coagulation factor X Homo sapiens 19000 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.092 10.7270/Q2SF2TFR 15664864 aid1797062 Groebke Zbinden, K; Banner, DW; Ackermann, J; D'Arcy, A; Kirchhofer, D; Ji, YH; Tschopp, TB; Wallbaum, S; Weber, L F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13576&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23283289 46513974 ZINC14953375 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24433 COc1cc(ccc1OCc1ccccc1)C(Nc1ccc(cc1)C(N)=N)C(=O)NCc1ccccc1 InChI=1S/C30H30N4O3/c1-36-27-18-24(14-17-26(27)37-20-22-10-6-3-7-11-22)28(30(35)33-19-21-8-4-2-5-9-21)34-25-15-12-23(13-16-25)29(31)32/h2-18,28,34H,19-20H2,1H3,(H3,31,32)(H,33,35) DRUZWKULMZFMLK-UHFFFAOYSA-N 13577 N-benzyl-2-[4-(benzyloxy)-3-methoxyphenyl]-2-[(4-carbamimidoylphenyl)amino]acetamide::phenylglycine amide compound 3 Coagulation factor X Homo sapiens 5300 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.092 10.7270/Q2SF2TFR 15664864 aid1797062 Groebke Zbinden, K; Banner, DW; Ackermann, J; D'Arcy, A; Kirchhofer, D; Ji, YH; Tschopp, TB; Wallbaum, S; Weber, L F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13577&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9848592 46513975 ZINC14953386 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24434 CCOc1cc(ccc1OCc1ccccc1)C(Nc1ccc(cc1)C(N)=N)C(=O)NCc1ccccc1 InChI=1S/C31H32N4O3/c1-2-37-28-19-25(15-18-27(28)38-21-23-11-7-4-8-12-23)29(31(36)34-20-22-9-5-3-6-10-22)35-26-16-13-24(14-17-26)30(32)33/h3-19,29,35H,2,20-21H2,1H3,(H3,32,33)(H,34,36) XBTPFPWYGMNPPA-UHFFFAOYSA-N 13578 N-benzyl-2-[4-(benzyloxy)-3-ethoxyphenyl]-2-[(4-carbamimidoylphenyl)amino]acetamide::phenylglycine amide compound 4 Coagulation factor X Homo sapiens 4500 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.092 10.7270/Q2SF2TFR 15664864 aid1797062 Groebke Zbinden, K; Banner, DW; Ackermann, J; D'Arcy, A; Kirchhofer, D; Ji, YH; Tschopp, TB; Wallbaum, S; Weber, L F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13578&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9870910 46513976 ZINC14953395 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24435 CCOc1ccc(CNc2ccc(cc2)C(N)=N)cc1OCC InChI=1S/C18H23N3O2/c1-3-22-16-10-5-13(11-17(16)23-4-2)12-21-15-8-6-14(7-9-15)18(19)20/h5-11,21H,3-4,12H2,1-2H3,(H3,19,20) KWXVDUACPKJCCN-UHFFFAOYSA-N 13579 4-{[(3,4-diethoxyphenyl)methyl]amino}benzene-1-carboximidamide::benzylamine 5 Coagulation factor X Homo sapiens 39000 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.092 10.7270/Q2SF2TFR 15664864 aid1797062 Groebke Zbinden, K; Banner, DW; Ackermann, J; D'Arcy, A; Kirchhofer, D; Ji, YH; Tschopp, TB; Wallbaum, S; Weber, L F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13579&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646461 46513977 ZINC14953400 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24436 COc1cc(CNc2ccc(cc2)C(N)=N)ccc1OCc1ccccc1 InChI=1S/C22H23N3O2/c1-26-21-13-17(14-25-19-10-8-18(9-11-19)22(23)24)7-12-20(21)27-15-16-5-3-2-4-6-16/h2-13,25H,14-15H2,1H3,(H3,23,24) YPLDWUAEABIXKN-UHFFFAOYSA-N 13580 4-({[4-(benzyloxy)-3-methoxyphenyl]methyl}amino)benzene-1-carboximidamide::benzylamine 6 Coagulation factor X Homo sapiens 1200 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.092 10.7270/Q2SF2TFR 15664864 aid1797062 Groebke Zbinden, K; Banner, DW; Ackermann, J; D'Arcy, A; Kirchhofer, D; Ji, YH; Tschopp, TB; Wallbaum, S; Weber, L F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13580&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646462 46513978 ZINC14953405 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24437 COc1cc(CNc2ccc(cc2)C(N)=N)c(NS(C)(=O)=O)cc1OCc1ccccc1 InChI=1S/C23H26N4O4S/c1-30-21-12-18(14-26-19-10-8-17(9-11-19)23(24)25)20(27-32(2,28)29)13-22(21)31-15-16-6-4-3-5-7-16/h3-13,26-27H,14-15H2,1-2H3,(H3,24,25) CRFICMUDNBIMKL-UHFFFAOYSA-N 13581 4-({[4-(benzyloxy)-2-methanesulfonamido-5-methoxyphenyl]methyl}amino)benzene-1-carboximidamide::benzylamine 7 Coagulation factor X Homo sapiens 26000 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.092 10.7270/Q2SF2TFR 15664864 aid1797062 Groebke Zbinden, K; Banner, DW; Ackermann, J; D'Arcy, A; Kirchhofer, D; Ji, YH; Tschopp, TB; Wallbaum, S; Weber, L F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13581&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 771 1W0Y 449091 46513979 ZINC14953411 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24438 COc1cc(C(Nc2ccc(cc2)C(N)=N)C(=O)NCc2ccccc2)c(cc1OCc1ccccc1)S(=O)(=O)c1ccccc1 InChI=1S/C36H34N4O5S/c1-44-31-21-30(33(46(42,43)29-15-9-4-10-16-29)22-32(31)45-24-26-13-7-3-8-14-26)34(36(41)39-23-25-11-5-2-6-12-25)40-28-19-17-27(18-20-28)35(37)38/h2-22,34,40H,23-24H2,1H3,(H3,37,38)(H,39,41) PVRUWGCKIMLDRQ-UHFFFAOYSA-N 13582 2-[2-(benzenesulfonyl)-4-(benzyloxy)-5-methoxyphenyl]-N-benzyl-2-[(4-carbamimidoylphenyl)amino]acetamide::phenylglycine amide compound 8 Coagulation factor X Homo sapiens >74000 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.092 10.7270/Q2SF2TFR 15664864 aid1797062 Groebke Zbinden, K; Banner, DW; Ackermann, J; D'Arcy, A; Kirchhofer, D; Ji, YH; Tschopp, TB; Wallbaum, S; Weber, L F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13582&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646463 46513980 ZINC28338317 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24439 COc1cc(ccc1OCc1ccccc1)[C@@H](Nc1ccc(cc1)C(N)=N)C(=O)N[C@H](C(O)=O)c1ccccc1 InChI=1S/C31H30N4O5/c1-39-26-18-23(14-17-25(26)40-19-20-8-4-2-5-9-20)27(34-24-15-12-22(13-16-24)29(32)33)30(36)35-28(31(37)38)21-10-6-3-7-11-21/h2-18,27-28,34H,19H2,1H3,(H3,32,33)(H,35,36)(H,37,38)/t27-,28+/m1/s1 WGEGXJPYFSZDMU-IZLXSDGUSA-N 13552 (2S)-2-[(2R)-2-[4-(benzyloxy)-3-methoxyphenyl]-2-[(4-carbamimidoylphenyl)amino]acetamido]-2-phenylacetic acid::phenylglycine amide compound 9::phenylglycine deriv. 1 Coagulation factor X Homo sapiens 8000 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.092 10.7270/Q2SF2TFR 15664864 aid1797062 Groebke Zbinden, K; Banner, DW; Ackermann, J; D'Arcy, A; Kirchhofer, D; Ji, YH; Tschopp, TB; Wallbaum, S; Weber, L F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13552&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 413 1W7X,1W8B 5287506 46513953 ZINC03932449 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24440 COc1cc(C(Nc2ccc(cc2)C(N)=N)C(=O)N[C@H](C(O)=O)c2ccccc2)c(cc1OCc1ccccc1)S(=O)(=O)c1ccccc1 InChI=1S/C37H34N4O7S/c1-47-30-21-29(32(49(45,46)28-15-9-4-10-16-28)22-31(30)48-23-24-11-5-2-6-12-24)34(40-27-19-17-26(18-20-27)35(38)39)36(42)41-33(37(43)44)25-13-7-3-8-14-25/h2-22,33-34,40H,23H2,1H3,(H3,38,39)(H,41,42)(H,43,44)/t33-,34?/m0/s1 VMAJIKJVRRFMIB-CDRRMRQFSA-N 13554 (2S)-2-{2-[2-(benzenesulfonyl)-4-(benzyloxy)-5-methoxyphenyl]-2-[(4-carbamimidoylphenyl)amino]acetamido}-2-phenylacetic acid::phenylglycine amide compound 10::phenylglycine deriv. 2 Coagulation factor X Homo sapiens 12400 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.092 10.7270/Q2SF2TFR 15664864 aid1797062 Groebke Zbinden, K; Banner, DW; Ackermann, J; D'Arcy, A; Kirchhofer, D; Ji, YH; Tschopp, TB; Wallbaum, S; Weber, L F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13554&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11250964 46513954 ZINC96210455 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24441 COc1cc(C(Nc2ccc(cc2)C(N)=N)C(=O)N[C@H](C(O)=O)c2ccccc2)c(cc1OCc1ccccc1)C(=O)Cc1ccccc1 InChI=1S/C39H36N4O6/c1-48-33-23-31(30(32(44)21-25-11-5-2-6-12-25)22-34(33)49-24-26-13-7-3-8-14-26)36(42-29-19-17-28(18-20-29)37(40)41)38(45)43-35(39(46)47)27-15-9-4-10-16-27/h2-20,22-23,35-36,42H,21,24H2,1H3,(H3,40,41)(H,43,45)(H,46,47)/t35-,36?/m0/s1 VTMDRMAPYBSBFM-TYIYNAFKSA-N 13555 (2S)-2-{2-[4-(benzyloxy)-5-methoxy-2-(2-phenylacetyl)phenyl]-2-[(4-carbamimidoylphenyl)amino]acetamido}-2-phenylacetic acid::phenylglycine amide compound 11::phenylglycine deriv. 3 Coagulation factor X Homo sapiens 19000 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.10.092 10.7270/Q2SF2TFR 15664864 aid1797062 Groebke Zbinden, K; Banner, DW; Ackermann, J; D'Arcy, A; Kirchhofer, D; Ji, YH; Tschopp, TB; Wallbaum, S; Weber, L F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13555&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11411220 46513955 ZINC96210456 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24467 CCOc1cc(OCC)cc(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C19H23N3O4/c1-3-25-15-9-13(10-16(11-15)26-4-2)17(19(23)24)22-14-7-5-12(6-8-14)18(20)21/h5-11,17,22H,3-4H2,1-2H3,(H3,20,21)(H,23,24) UXQFXLBBPPHNHB-UHFFFAOYSA-N 13558 2-[(4-carbamimidoylphenyl)amino]-2-(3,5-diethoxyphenyl)acetic acid::phenylglycine deriv. 6::phenylglycine derivative 1 Coagulation factor X Homo sapiens 5600 Curated from the literature by BindingDB 10.1016/j.bmc.2006.03.042 10.7270/Q2NP22PZ 16621574 aid1797066 Groebke Zbinden, K; Banner, DW; Hilpert, K; Himber, J; Lave, T; Riederer, MA; Stahl, M; Tschopp, TB; Obst-Sander, U F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13558&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646453 46513958 ZINC14953231 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24468 CCOc1cc(OCC)c(F)c(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C19H22FN3O4/c1-3-26-13-9-14(16(20)15(10-13)27-4-2)17(19(24)25)23-12-7-5-11(6-8-12)18(21)22/h5-10,17,23H,3-4H2,1-2H3,(H3,21,22)(H,24,25) DZEPTAZKEKTXAE-UHFFFAOYSA-N 13587 (RS)-(4-carbamimidoyl-phenylamino)-(3,5-diethoxy-2-fluoro-phenyl)-acetic acid::2-[(4-carbamimidoylphenyl)amino]-2-(3,5-diethoxy-2-fluorophenyl)acetic acid::phenylglycine derivative 2 Coagulation factor X Homo sapiens 3000 Curated from the literature by BindingDB 10.1016/j.bmc.2006.03.042 10.7270/Q2NP22PZ 16621574 aid1797066 Groebke Zbinden, K; Banner, DW; Hilpert, K; Himber, J; Lave, T; Riederer, MA; Stahl, M; Tschopp, TB; Obst-Sander, U F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13587&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9907633 46513983 ZINC14953420 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24469 CCOc1cc(OC2CCOC2)cc(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C21H25N3O5/c1-2-28-17-9-14(10-18(11-17)29-16-7-8-27-12-16)19(21(25)26)24-15-5-3-13(4-6-15)20(22)23/h3-6,9-11,16,19,24H,2,7-8,12H2,1H3,(H3,22,23)(H,25,26) ZKEPSHHZWYCVRH-UHFFFAOYSA-N 13588 (4-Carbamimidoyl-phenylamino)-[3-ethoxy-5-(tetra-hydrofuran-3-yloxy)-phenyl]-acetic acid::2-[(4-carbamimidoylphenyl)amino]-2-[3-ethoxy-5-(oxolan-3-yloxy)phenyl]acetic acid::phenylglycine derivative 3 Coagulation factor X Homo sapiens 2900 Curated from the literature by BindingDB 10.1016/j.bmc.2006.03.042 10.7270/Q2NP22PZ 16621574 aid1797066 Groebke Zbinden, K; Banner, DW; Hilpert, K; Himber, J; Lave, T; Riederer, MA; Stahl, M; Tschopp, TB; Obst-Sander, U F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13588&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646464 46513984 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24470 CCOc1cc(OC2CCOC2)c(F)c(c1)C(Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C21H24FN3O5/c1-2-29-15-9-16(18(22)17(10-15)30-14-7-8-28-11-14)19(21(26)27)25-13-5-3-12(4-6-13)20(23)24/h3-6,9-10,14,19,25H,2,7-8,11H2,1H3,(H3,23,24)(H,26,27) PGYOHIAQCFZQDK-UHFFFAOYSA-N 13589 (4-carbamimidoyl-phenylamino)-[3-ethoxy-2-fluoro-5-(tetrahydro-furan-3- yloxy)-phenyl]-acetic acid::2-[(4-carbamimidoylphenyl)amino]-2-[5-ethoxy-2-fluoro-3-(oxolan-3-yloxy)phenyl]acetic acid::phenylglycine derivative 4 Coagulation factor X Homo sapiens 1200 Curated from the literature by BindingDB 10.1016/j.bmc.2006.03.042 10.7270/Q2NP22PZ 16621574 aid1797066 Groebke Zbinden, K; Banner, DW; Hilpert, K; Himber, J; Lave, T; Riederer, MA; Stahl, M; Tschopp, TB; Obst-Sander, U F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13589&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 346 2BZ6 18551830 46513985 ZINC62027142 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24471 CCOc1cc(O[C@@H]2CCOC2)c(F)c(c1)[C@@H](Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C21H24FN3O5/c1-2-29-15-9-16(18(22)17(10-15)30-14-7-8-28-11-14)19(21(26)27)25-13-5-3-12(4-6-13)20(23)24/h3-6,9-10,14,19,25H,2,7-8,11H2,1H3,(H3,23,24)(H,26,27)/t14-,19-/m1/s1 PGYOHIAQCFZQDK-AUUYWEPGSA-N 13590 (2R)-2-[(4-carbamimidoylphenyl)amino]-2-{5-ethoxy-2-fluoro-3-[(3R)-oxolan-3-yloxy]phenyl}acetic acid::(R)-(4-Carbamimidoyl-phenylamino)-{3-ethoxy-2-fluoro-5-[(R)-(tetra-hydro-furan-3-yl)-oxy]-phenyl}-acetic acid::phenylglycine derivative 5 Coagulation factor X Homo sapiens 1900 Curated from the literature by BindingDB 10.1016/j.bmc.2006.03.042 10.7270/Q2NP22PZ 16621574 aid1797066 Groebke Zbinden, K; Banner, DW; Hilpert, K; Himber, J; Lave, T; Riederer, MA; Stahl, M; Tschopp, TB; Obst-Sander, U F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13590&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 346 2BZ6 6852220 46513986 DB04590 ZINC12504433 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24472 CCOc1cc(O[C@H]2CCOC2)c(F)c(c1)[C@@H](Nc1ccc(cc1)C(N)=N)C(O)=O InChI=1S/C21H24FN3O5/c1-2-29-15-9-16(18(22)17(10-15)30-14-7-8-28-11-14)19(21(26)27)25-13-5-3-12(4-6-13)20(23)24/h3-6,9-10,14,19,25H,2,7-8,11H2,1H3,(H3,23,24)(H,26,27)/t14-,19+/m0/s1 PGYOHIAQCFZQDK-IFXJQAMLSA-N 13591 (2R)-2-[(4-carbamimidoylphenyl)amino]-2-{5-ethoxy-2-fluoro-3-[(3S)-oxolan-3-yloxy]phenyl}acetic acid::(R)-(4-Carbamimidoyl-phenylamino)-{3-ethoxy-2-fluoro-5-[(S)-(tetra-hydro-furan-3-yl)-oxy]-phenyl}-acetic acid::phenylglycine derivative 6 Coagulation factor X Homo sapiens 410 Curated from the literature by BindingDB 10.1016/j.bmc.2006.03.042 10.7270/Q2NP22PZ 16621574 aid1797066 Groebke Zbinden, K; Banner, DW; Hilpert, K; Himber, J; Lave, T; Riederer, MA; Stahl, M; Tschopp, TB; Obst-Sander, U F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13591&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646465 46513987 ZINC14953424 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24473 COc1ccc(-c2ccc(cc2C(O)=O)C(=O)N[C@H](CO)C(C)(C)C)c(n1)C(=O)Nc1ccc(cc1)C(N)=N InChI=1S/C28H31N5O6/c1-28(2,3)21(14-34)32-25(35)16-7-10-18(20(13-16)27(37)38)19-11-12-22(39-4)33-23(19)26(36)31-17-8-5-15(6-9-17)24(29)30/h5-13,21,34H,14H2,1-4H3,(H3,29,30)(H,31,36)(H,32,35)(H,37,38)/t21-/m1/s1 KPACBFJTZSMBKD-OAQYLSRUSA-N 13592 2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxypyridin-3-yl}-5-{[(2S)-1-hydroxy-3,3-dimethylbutan-2-yl]carbamoyl}benzoic acid::Ono Compound 8 Coagulation factor X Homo sapiens 150 Curated from the literature by BindingDB 10.1016/j.bmc.2006.03.042 10.7270/Q2NP22PZ 16621574 aid1797066 Groebke Zbinden, K; Banner, DW; Hilpert, K; Himber, J; Lave, T; Riederer, MA; Stahl, M; Tschopp, TB; Obst-Sander, U F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13592&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1NJ 4JZD 6102731 46513988 ZINC14953429 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23333 CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)NCc1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C31H38Cl2N8O4S/c1-18(2)25(28(44)39-23(9-6-12-37-30(34)35)26(42)29-36-13-14-46-29)41-27(43)24(16-19-7-4-3-5-8-19)40-31(45)38-17-20-10-11-21(32)22(33)15-20/h3-5,7-8,10-11,13-15,18,23-25H,6,9,12,16-17H2,1-2H3,(H,39,44)(H,41,43)(H4,34,35,37)(H2,38,40,45)/t23-,24-,25-/m0/s1 LLSMVIKCWLJOBO-SDHOMARFSA-N 12946 (2S)-N-[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-2-[(2S)-2-({[(3,4-dichlorophenyl)methyl]carbamoyl}amino)-3-phenylpropanamido]-3-methylbutanamide::alpha-ketothiazole analogue 7 Coagulation factor X Homo sapiens 14200 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12946&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098887 46513385 ZINC29125556 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23334 CCOC(=O)C(Cc1ccccc1)NC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C35H46N8O6S/c1-4-49-33(47)27(21-24-14-9-6-10-15-24)42-35(48)41-26(20-23-12-7-5-8-13-23)30(45)43-28(22(2)3)31(46)40-25(16-11-17-39-34(36)37)29(44)32-38-18-19-50-32/h5-10,12-15,18-19,22,25-28H,4,11,16-17,20-21H2,1-3H3,(H,40,46)(H,43,45)(H4,36,37,39)(H2,41,42,48)/t25-,26-,27?,28-/m0/s1 KWHYCQNWBDQDDM-QGMKSFRFSA-N 12949 alpha-ketothiazole analogue 9::ethyl 2-({[(1S)-1-{[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-methylpropyl]carbamoyl}-2-phenylethyl]carbamoyl}amino)-3-phenylpropanoate Coagulation factor X Homo sapiens 14300 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12949&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098889 46512944 ZINC96210421 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23335 CCOC(=O)C(CC(C)C)NC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C32H48N8O6S/c1-6-46-30(44)24(17-19(2)3)39-32(45)38-23(18-21-11-8-7-9-12-21)27(42)40-25(20(4)5)28(43)37-22(13-10-14-36-31(33)34)26(41)29-35-15-16-47-29/h7-9,11-12,15-16,19-20,22-25H,6,10,13-14,17-18H2,1-5H3,(H,37,43)(H,40,42)(H4,33,34,36)(H2,38,39,45)/t22-,23-,24?,25-/m0/s1 SVYBVUSHOXDEHY-DRNWNIILSA-N 12950 alpha-ketothiazole analogue 10::ethyl 2-({[(1S)-1-{[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-methylpropyl]carbamoyl}-2-phenylethyl]carbamoyl}amino)-4-methylpentanoate Coagulation factor X Homo sapiens 15400 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12950&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098890 46512945 ZINC96210425 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23336 CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)Nc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C30H38N8O4S/c1-19(2)24(27(41)36-22(14-9-15-34-29(31)32)25(39)28-33-16-17-43-28)38-26(40)23(18-20-10-5-3-6-11-20)37-30(42)35-21-12-7-4-8-13-21/h3-8,10-13,16-17,19,22-24H,9,14-15,18H2,1-2H3,(H,36,41)(H,38,40)(H4,31,32,34)(H2,35,37,42)/t22-,23-,24-/m0/s1 IUSNMQXYUHORTN-HJOGWXRNSA-N 12951 (2S)-N-[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-3-methyl-2-[(2S)-3-phenyl-2-[(phenylcarbamoyl)amino]propanamido]butanamide::alpha-ketothiazole analogue 11 Coagulation factor X Homo sapiens >20000 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12951&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098891 46513388 ZINC14951582 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23337 CC(C)C[C@H](NC(=O)NCc1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C28H40Cl2N8O4S/c1-15(2)12-21(37-28(42)35-14-17-7-8-18(29)19(30)13-17)24(40)38-22(16(3)4)25(41)36-20(6-5-9-34-27(31)32)23(39)26-33-10-11-43-26/h7-8,10-11,13,15-16,20-22H,5-6,9,12,14H2,1-4H3,(H,36,41)(H,38,40)(H4,31,32,34)(H2,35,37,42)/t20-,21-,22-/m0/s1 TZODCMWFXOTDNK-FKBYEOEOSA-N 12955 (2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-methylpropyl]-2-({[(3,4-dichlorophenyl)methyl]carbamoyl}amino)-4-methylpentanamide::alpha-ketothiazole analogue 15 Coagulation factor X Homo sapiens >20000 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12955&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11273795 46513392 ZINC29125515 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23338 CCC(C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)NCc1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C29H42Cl2N8O4S/c1-5-17(4)23(26(42)37-21(7-6-10-35-28(32)33)24(40)27-34-11-12-44-27)39-25(41)22(13-16(2)3)38-29(43)36-15-18-8-9-19(30)20(31)14-18/h8-9,11-12,14,16-17,21-23H,5-7,10,13,15H2,1-4H3,(H,37,42)(H,39,41)(H4,32,33,35)(H2,36,38,43)/t17?,21-,22-,23-/m0/s1 GVTZNVAHOSYMTK-PRKPZBFWSA-N 12956 (2S,3R)-N-[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-2-[(2S)-2-({[(3,4-dichlorophenyl)methyl]carbamoyl}amino)-4-methylpentanamido]-3-methylpentanamide::alpha-ketothiazole analogue 16 Coagulation factor X Homo sapiens 85000 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12956&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646329 46513393 ZINC37868458 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23339 CC(C)C[C@H](NC(=O)NCc1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C32H40Cl2N8O5S/c1-18(2)14-25(42-32(47)39-17-20-7-10-22(33)23(34)15-20)28(45)41-26(16-19-5-8-21(43)9-6-19)29(46)40-24(4-3-11-38-31(35)36)27(44)30-37-12-13-48-30/h5-10,12-13,15,18,24-26,43H,3-4,11,14,16-17H2,1-2H3,(H,40,46)(H,41,45)(H4,35,36,38)(H2,39,42,47)/t24-,25-,26-/m0/s1 UDYLFWYFTHNPLS-GSDHBNRESA-N 12957 (2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]-2-({[(3,4-dichlorophenyl)methyl]carbamoyl}amino)-4-methylpentanamide::alpha-ketothiazole analogue 17 Coagulation factor X Homo sapiens 1700 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12957&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098895 46509409 ZINC34689246 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24511 Clc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)nc1 InChI=1S/C25H26Cl2N4O2/c26-20-2-3-21(29-17-20)9-14-33-24-15-19(1-4-23(24)27)25(32)30-16-18-7-12-31(13-8-18)22-5-10-28-11-6-22/h1-6,10-11,15,17-18H,7-9,12-14,16H2,(H,30,32) AKPBXRZTJLYEEN-UHFFFAOYSA-N 13615 3-Oxybenzamide 1::4-chloro-3-[2-(5-chloropyridin-2-yl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 20 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13615&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052426 46514007 ZINC13643332 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24512 Fc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C26H26Cl2FN3O2/c27-21-3-1-19(23(28)16-21)9-14-34-25-15-20(2-4-24(25)29)26(33)31-17-18-7-12-32(13-8-18)22-5-10-30-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17H2,(H,31,33) WKMDLCMGKOYKFG-UHFFFAOYSA-N 13616 3-Oxybenzamide 2::3-[2-(2,4-dichlorophenyl)ethoxy]-4-fluoro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 50 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13616&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396199 46514008 ZINC13643334 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24513 Fc1ccc(cc1OCCc1ccc(Cl)cc1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C26H27ClFN3O2/c27-22-4-1-19(2-5-22)11-16-33-25-17-21(3-6-24(25)28)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18H2,(H,30,32) SPSKAYMQPXKPMJ-UHFFFAOYSA-N 13617 3-Oxybenzamide 3::3-[2-(4-chlorophenyl)ethoxy]-4-fluoro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 40 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13617&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052371 46514009 ZINC13643337 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24514 Fc1ccc(cc1OCCc1ccc(Cl)cn1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C25H26ClFN4O2/c26-20-2-3-21(29-17-20)9-14-33-24-15-19(1-4-23(24)27)25(32)30-16-18-7-12-31(13-8-18)22-5-10-28-11-6-22/h1-6,10-11,15,17-18H,7-9,12-14,16H2,(H,30,32) LTHCKUVKEGEEGL-UHFFFAOYSA-N 13618 3-Oxybenzamide 4::3-[2-(5-chloropyridin-2-yl)ethoxy]-4-fluoro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 37 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13618&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052373 46514010 ZINC13643339 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24515 Clc1ccc(cc1OCCc1ccc(Br)cc1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C26H27BrClN3O2/c27-22-4-1-19(2-5-22)11-16-33-25-17-21(3-6-24(25)28)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18H2,(H,30,32) MNIIBNMCMGLNIR-UHFFFAOYSA-N 13619 3-Oxybenzamide 5::3-[2-(4-bromophenyl)ethoxy]-4-chloro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 36 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13619&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396255 46514011 ZINC14953463 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24516 Fc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C26H27ClFN3O2/c27-24-6-3-21(17-25(24)33-16-11-19-1-4-22(28)5-2-19)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18H2,(H,30,32) CKSYIUHRYUDSQE-UHFFFAOYSA-N 13620 3-Oxybenzamide 6::4-chloro-3-[2-(4-fluorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 102 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13620&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396287 46514012 ZINC13643341 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24517 Cc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C27H30ClN3O2/c1-20-2-4-21(5-3-20)12-17-33-26-18-23(6-7-25(26)28)27(32)30-19-22-10-15-31(16-11-22)24-8-13-29-14-9-24/h2-9,13-14,18,22H,10-12,15-17,19H2,1H3,(H,30,32) MYMXDIMTTAYBBP-UHFFFAOYSA-N 13621 3-Oxybenzamide 7::4-chloro-3-[2-(4-methylphenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 124 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13621&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396288 46514013 ZINC13643344 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24518 COc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C27H30ClN3O3/c1-33-24-5-2-20(3-6-24)12-17-34-26-18-22(4-7-25(26)28)27(32)30-19-21-10-15-31(16-11-21)23-8-13-29-14-9-23/h2-9,13-14,18,21H,10-12,15-17,19H2,1H3,(H,30,32) UNHPOJGJLQUPNH-UHFFFAOYSA-N 13622 3-Oxybenzamide 8::4-chloro-3-[2-(4-methoxyphenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 314 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13622&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052493 46514014 ZINC13643346 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24519 Clc1ccc(cc1OCCc1ccc(cc1)C#N)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H27ClN4O2/c28-25-6-5-23(17-26(25)34-16-11-20-1-3-21(18-29)4-2-20)27(33)31-19-22-9-14-32(15-10-22)24-7-12-30-13-8-24/h1-8,12-13,17,22H,9-11,14-16,19H2,(H,31,33) GTHTVLJAXOPDRK-UHFFFAOYSA-N 13623 3-Oxybenzamide 9::4-chloro-3-[2-(4-cyanophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 1552 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13623&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396286 46514015 ZINC13643349 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24520 Clc1cccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)c1 InChI=1S/C26H27Cl2N3O2/c27-22-3-1-2-19(16-22)10-15-33-25-17-21(4-5-24(25)28)26(32)30-18-20-8-13-31(14-9-20)23-6-11-29-12-7-23/h1-7,11-12,16-17,20H,8-10,13-15,18H2,(H,30,32) XKBUEUQVUBZXMJ-UHFFFAOYSA-N 13624 3-Oxybenzamide 10::4-chloro-3-[2-(3-chlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 1931 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13624&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396282 46514016 ZINC13643351 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24521 COc1cccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)c1 InChI=1S/C27H30ClN3O3/c1-33-24-4-2-3-20(17-24)11-16-34-26-18-22(5-6-25(26)28)27(32)30-19-21-9-14-31(15-10-21)23-7-12-29-13-8-23/h2-8,12-13,17-18,21H,9-11,14-16,19H2,1H3,(H,30,32) KAZPUVKCBZSLAR-UHFFFAOYSA-N 13625 3-Oxybenzamide 11::4-chloro-3-[2-(3-methoxyphenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 2494 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13625&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396283 46514017 ZINC13643353 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24522 Nc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C26H29ClN4O2/c27-24-6-3-21(17-25(24)33-16-11-19-1-4-22(28)5-2-19)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18,28H2,(H,30,32) CVUVHSMJDWAULJ-UHFFFAOYSA-N 13626 3-Oxybenzamide 12::3-[2-(4-aminophenyl)ethoxy]-4-chloro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 420 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13626&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052453 46514018 ZINC13643355 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24523 CC(C)(C)OC(=O)Nc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C31H37ClN4O4/c1-31(2,3)40-30(38)35-25-7-4-22(5-8-25)14-19-39-28-20-24(6-9-27(28)32)29(37)34-21-23-12-17-36(18-13-23)26-10-15-33-16-11-26/h4-11,15-16,20,23H,12-14,17-19,21H2,1-3H3,(H,34,37)(H,35,38) JIBPEZNZJOOEKR-UHFFFAOYSA-N 13627 3-Oxybenzamide 13::tert-butyl N-(4-{2-[2-chloro-5-({[1-(pyridin-4-yl)piperidin-4-yl]methyl}carbamoyl)phenoxy]ethyl}phenyl)carbamate Coagulation factor X Homo sapiens 4531 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13627&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396327 46514019 ZINC14953469 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24524 CC(=O)Nc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C28H31ClN4O3/c1-20(34)32-24-5-2-21(3-6-24)12-17-36-27-18-23(4-7-26(27)29)28(35)31-19-22-10-15-33(16-11-22)25-8-13-30-14-9-25/h2-9,13-14,18,22H,10-12,15-17,19H2,1H3,(H,31,35)(H,32,34) VETSMHJHAVKZAN-UHFFFAOYSA-N 13628 3-Oxybenzamide 14::4-chloro-3-[2-(4-acetamidophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 10000 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13628&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646472 46514020 ZINC13643357 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24525 Fc1ccc(cc1OCCc1ccc(Br)cc1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C26H27BrFN3O2/c27-22-4-1-19(2-5-22)11-16-33-25-17-21(3-6-24(25)28)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18H2,(H,30,32) KREFHLJLUUEHNH-UHFFFAOYSA-N 13629 3-Oxybenzamide 15::3-[2-(4-bromophenyl)ethoxy]-4-fluoro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 71 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13629&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396256 46514021 ZINC13643359 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24530 Fc1ccc(CCOc2cc(ccc2F)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C26H27F2N3O2/c27-22-4-1-19(2-5-22)11-16-33-25-17-21(3-6-24(25)28)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18H2,(H,30,32) PQLDYDZUMUCCQC-UHFFFAOYSA-N 13630 3-Oxybenzamide 16::4-fluoro-3-[2-(4-fluorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 203 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13630&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396290 46514022 ZINC13643362 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24531 Cc1ccc(CCOc2cc(ccc2F)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C27H30FN3O2/c1-20-2-4-21(5-3-20)12-17-33-26-18-23(6-7-25(26)28)27(32)30-19-22-10-15-31(16-11-22)24-8-13-29-14-9-24/h2-9,13-14,18,22H,10-12,15-17,19H2,1H3,(H,30,32) YDFSVSGREUOAEZ-UHFFFAOYSA-N 13631 3-Oxybenzamide 17::4-fluoro-3-[2-(4-methylphenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 206 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13631&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396292 46514023 ZINC13643365 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24532 COc1ccc(CCOc2cc(ccc2F)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C27H30FN3O3/c1-33-24-5-2-20(3-6-24)12-17-34-26-18-22(4-7-25(26)28)27(32)30-19-21-10-15-31(16-11-21)23-8-13-29-14-9-23/h2-9,13-14,18,21H,10-12,15-17,19H2,1H3,(H,30,32) SUDGKHGTKKJQCF-UHFFFAOYSA-N 13632 3-Oxybenzamide 18::4-fluoro-3-[2-(4-methoxyphenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 307 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13632&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396291 46514024 ZINC13643367 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24533 Fc1ccc(cc1OCCc1ccc(cc1)C#N)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H27FN4O2/c28-25-6-5-23(17-26(25)34-16-11-20-1-3-21(18-29)4-2-20)27(33)31-19-22-9-14-32(15-10-22)24-7-12-30-13-8-24/h1-8,12-13,17,22H,9-11,14-16,19H2,(H,31,33) MWAZJUSHGPEJEM-UHFFFAOYSA-N 13633 3-Oxybenzamide 19::3-[2-(4-cyanophenyl)ethoxy]-4-fluoro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 4605 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13633&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396259 46514025 ZINC13643369 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24534 Fc1ccc(cc1OCCc1cccc(Cl)c1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C26H27ClFN3O2/c27-22-3-1-2-19(16-22)10-15-33-25-17-21(4-5-24(25)28)26(32)30-18-20-8-13-31(14-9-20)23-6-11-29-12-7-23/h1-7,11-12,16-17,20H,8-10,13-15,18H2,(H,30,32) RHJHCDDSINXMPN-UHFFFAOYSA-N 13634 3-Oxybenzamide 20::3-[2-(3-chlorophenyl)ethoxy]-4-fluoro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 712 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13634&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396254 46514026 ZINC13643373 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24535 COc1cccc(CCOc2cc(ccc2F)C(=O)NCC2CCN(CC2)c2ccncc2)c1 InChI=1S/C27H30FN3O3/c1-33-24-4-2-3-20(17-24)11-16-34-26-18-22(5-6-25(26)28)27(32)30-19-21-9-14-31(15-10-21)23-7-12-29-13-8-23/h2-8,12-13,17-18,21H,9-11,14-16,19H2,1H3,(H,30,32) WLNFMTABODWTMD-UHFFFAOYSA-N 13635 3-Oxybenzamide 21::4-fluoro-3-[2-(3-methoxyphenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 3348 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13635&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396289 46514027 ZINC13643375 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24536 Nc1ccc(CCOc2cc(ccc2F)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C26H29FN4O2/c27-24-6-3-21(17-25(24)33-16-11-19-1-4-22(28)5-2-19)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18,28H2,(H,30,32) USYBQIBCQASYJA-UHFFFAOYSA-N 13636 3-Oxybenzamide 22::3-[2-(4-aminophenyl)ethoxy]-4-fluoro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 1554 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13636&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052465 46514028 ZINC12355245 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24537 CC(C)(C)OC(=O)Nc1ccc(CCOc2cc(ccc2F)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C31H37FN4O4/c1-31(2,3)40-30(38)35-25-7-4-22(5-8-25)14-19-39-28-20-24(6-9-27(28)32)29(37)34-21-23-12-17-36(18-13-23)26-10-15-33-16-11-26/h4-11,15-16,20,23H,12-14,17-19,21H2,1-3H3,(H,34,37)(H,35,38) QXLYGSVBJIHLCV-UHFFFAOYSA-N 13637 3-Oxybenzamide 23::tert-butyl N-(4-{2-[2-fluoro-5-({[1-(pyridin-4-yl)piperidin-4-yl]methyl}carbamoyl)phenoxy]ethyl}phenyl)carbamate Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13637&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396328 46514029 ZINC14953474 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24538 CC(=O)Nc1ccc(CCOc2cc(ccc2F)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C28H31FN4O3/c1-20(34)32-24-5-2-21(3-6-24)12-17-36-27-18-23(4-7-26(27)29)28(35)31-19-22-10-15-33(16-11-22)25-8-13-30-14-9-25/h2-9,13-14,18,22H,10-12,15-17,19H2,1H3,(H,31,35)(H,32,34) AHHUNHJRGPZSCF-UHFFFAOYSA-N 13638 3-Oxybenzamide 24::3-[2-(4-acetamidophenyl)ethoxy]-4-fluoro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13638&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646473 46514030 ZINC13643377 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24539 Clc1ccc(CCOc2cccc(c2)C(=O)NCC2CCN(CC2)c2ccncc2)c(Cl)c1 InChI=1S/C26H27Cl2N3O2/c27-22-5-4-20(25(28)17-22)10-15-33-24-3-1-2-21(16-24)26(32)30-18-19-8-13-31(14-9-19)23-6-11-29-12-7-23/h1-7,11-12,16-17,19H,8-10,13-15,18H2,(H,30,32) AQDTWVBZQDZQEZ-UHFFFAOYSA-N 13639 3-Oxybenzamide 25::3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 106 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13639&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052368 46514031 ZINC13643379 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24540 Clc1ccc(CCOc2cc(ccc2Br)C(=O)NCC2CCN(CC2)c2ccncc2)c(Cl)c1 InChI=1S/C26H26BrCl2N3O2/c27-23-4-2-20(15-25(23)34-14-9-19-1-3-21(28)16-24(19)29)26(33)31-17-18-7-12-32(13-8-18)22-5-10-30-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17H2,(H,31,33) ADLCQQQYJWNTLY-UHFFFAOYSA-N 13640 3-Oxybenzamide 26::4-bromo-3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 76 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13640&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052436 46514032 ZINC14953480 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24541 Clc1ccc(CCOc2cc(ccc2I)C(=O)NCC2CCN(CC2)c2ccncc2)c(Cl)c1 InChI=1S/C26H26Cl2IN3O2/c27-21-3-1-19(23(28)16-21)9-14-34-25-15-20(2-4-24(25)29)26(33)31-17-18-7-12-32(13-8-18)22-5-10-30-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17H2,(H,31,33) VYXSHJXKMJITQQ-UHFFFAOYSA-N 13641 3-Oxybenzamide 27::3-[2-(2,4-dichlorophenyl)ethoxy]-4-iodo-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 156 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13641&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646474 46514033 ZINC14953485 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24542 Cc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H29Cl2N3O2/c1-19-2-3-22(16-26(19)34-15-10-21-4-5-23(28)17-25(21)29)27(33)31-18-20-8-13-32(14-9-20)24-6-11-30-12-7-24/h2-7,11-12,16-17,20H,8-10,13-15,18H2,1H3,(H,31,33) QPHKHBUNEICWPT-UHFFFAOYSA-N 13642 3-Oxybenzamide 28::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methyl-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 37 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13642&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396230 46514034 ZINC03989404 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24543 FC(F)(F)c1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H26Cl2F3N3O2/c28-21-3-1-19(24(29)16-21)9-14-37-25-15-20(2-4-23(25)27(30,31)32)26(36)34-17-18-7-12-35(13-8-18)22-5-10-33-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17H2,(H,34,36) IVCLCGPMDAQQDD-UHFFFAOYSA-N 13643 3-Oxybenzamide 29::3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}-4-(trifluoromethyl)benzamide Coagulation factor X Homo sapiens 140 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13643&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052347 46514035 ZINC14953491 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24544 Clc1ccc(CCOc2cc(ccc2C#N)C(=O)NCC2CCN(CC2)c2ccncc2)c(Cl)c1 InChI=1S/C27H26Cl2N4O2/c28-23-4-3-20(25(29)16-23)9-14-35-26-15-21(1-2-22(26)17-30)27(34)32-18-19-7-12-33(13-8-19)24-5-10-31-11-6-24/h1-6,10-11,15-16,19H,7-9,12-14,18H2,(H,32,34) AZHZJSKJTQJFIZ-UHFFFAOYSA-N 13644 3-Oxybenzamide 30::4-cyano-3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 44 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13644&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052485 46514036 ZINC13643381 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24547 Nc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C26H28Cl2N4O2/c27-21-3-1-19(23(28)16-21)9-14-34-25-15-20(2-4-24(25)29)26(33)31-17-18-7-12-32(13-8-18)22-5-10-30-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17,29H2,(H,31,33) USTDQHUKYVFTSB-UHFFFAOYSA-N 13645 3-Oxybenzamide 31::4-amino-3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 29 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13645&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052320 46514037 ZINC00596623 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24548 CNc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H30Cl2N4O2/c1-30-25-5-3-21(16-26(25)35-15-10-20-2-4-22(28)17-24(20)29)27(34)32-18-19-8-13-33(14-9-19)23-6-11-31-12-7-23/h2-7,11-12,16-17,19,30H,8-10,13-15,18H2,1H3,(H,32,34) XWSIHPCRYGDRLR-UHFFFAOYSA-N 13646 3-Oxybenzamide 32::3-[2-(2,4-dichlorophenyl)ethoxy]-4-(methylamino)-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 48 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13646&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052309 46514038 ZINC13643383 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24549 Clc1ccc(CCOc2cc(ccc2NC=O)C(=O)NCC2CCN(CC2)c2ccncc2)c(Cl)c1 InChI=1S/C27H28Cl2N4O3/c28-22-3-1-20(24(29)16-22)9-14-36-26-15-21(2-4-25(26)32-18-34)27(35)31-17-19-7-12-33(13-8-19)23-5-10-30-11-6-23/h1-6,10-11,15-16,18-19H,7-9,12-14,17H2,(H,31,35)(H,32,34) PAURWMOEDJATQA-UHFFFAOYSA-N 13647 3-Oxybenzamide 33::3-[2-(2,4-dichlorophenyl)ethoxy]-1-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzene-1,4-dicarboxamide Coagulation factor X Homo sapiens 75 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13647&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052484 46514039 C06049 ZINC13643385 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24550 CC(=O)Nc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C28H30Cl2N4O3/c1-19(35)33-26-5-3-22(16-27(26)37-15-10-21-2-4-23(29)17-25(21)30)28(36)32-18-20-8-13-34(14-9-20)24-6-11-31-12-7-24/h2-7,11-12,16-17,20H,8-10,13-15,18H2,1H3,(H,32,36)(H,33,35) NDDNITDSHULYDX-UHFFFAOYSA-N 13648 3-Oxybenzamide 34::3-[2-(2,4-dichlorophenyl)ethoxy]-4-acetamido-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 316 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13648&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052326 46514040 ZINC14953497 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24551 NC(=O)Nc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H29Cl2N5O3/c28-21-3-1-19(23(29)16-21)9-14-37-25-15-20(2-4-24(25)33-27(30)36)26(35)32-17-18-7-12-34(13-8-18)22-5-10-31-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17H2,(H,32,35)(H3,30,33,36) PZTVPHNZFYDIEQ-UHFFFAOYSA-N 13649 3-Oxybenzamide 35::4-(carbamoylamino)-3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 1763 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13649&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052377 46514041 ZINC14953503 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24552 NC(=O)c1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H28Cl2N4O3/c28-21-3-1-19(24(29)16-21)9-14-36-25-15-20(2-4-23(25)26(30)34)27(35)32-17-18-7-12-33(13-8-18)22-5-10-31-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17H2,(H2,30,34)(H,32,35) RAVOKSWRPDYRAE-UHFFFAOYSA-N 13650 3-Oxybenzamide 36::3-[2-(2,4-dichlorophenyl)ethoxy]-1-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzene-1,4-dicarboxamide Coagulation factor X Homo sapiens 588 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13650&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396194 46514042 ZINC13643387 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24553 NC(=O)c1cc(OCCc2ccc(Cl)cc2Cl)cc(c1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H28Cl2N4O3/c28-22-2-1-19(25(29)16-22)7-12-36-24-14-20(26(30)34)13-21(15-24)27(35)32-17-18-5-10-33(11-6-18)23-3-8-31-9-4-23/h1-4,8-9,13-16,18H,5-7,10-12,17H2,(H2,30,34)(H,32,35) ZKSQIMPBUMVRHT-UHFFFAOYSA-N 13651 3-Oxybenzamide 37::5-[2-(2,4-dichlorophenyl)ethoxy]-1-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzene-1,3-dicarboxamide Coagulation factor X Homo sapiens 51 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13651&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10052619 46514043 ZINC13643389 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24554 CSc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H29Cl2N3O2S/c1-35-26-5-3-21(16-25(26)34-15-10-20-2-4-22(28)17-24(20)29)27(33)31-18-19-8-13-32(14-9-19)23-6-11-30-12-7-23/h2-7,11-12,16-17,19H,8-10,13-15,18H2,1H3,(H,31,33) BCQQWWXAOHPASE-UHFFFAOYSA-N 13652 3-Oxybenzamide 38::3-[2-(2,4-dichlorophenyl)ethoxy]-4-(methylsulfanyl)-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 28 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13652&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052452 46514044 ZINC03989406 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24555 CCOc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C28H31Cl2N3O3/c1-2-35-26-6-4-22(17-27(26)36-16-11-21-3-5-23(29)18-25(21)30)28(34)32-19-20-9-14-33(15-10-20)24-7-12-31-13-8-24/h3-8,12-13,17-18,20H,2,9-11,14-16,19H2,1H3,(H,32,34) ZXKUYRLODOJGJS-UHFFFAOYSA-N 13653 3-Oxybenzamide 39::3-[2-(2,4-dichlorophenyl)ethoxy]-4-ethoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 61 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13653&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052325 46514045 ZINC13643392 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24556 CC(C)Oc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C29H33Cl2N3O3/c1-20(2)37-27-6-4-23(17-28(27)36-16-11-22-3-5-24(30)18-26(22)31)29(35)33-19-21-9-14-34(15-10-21)25-7-12-32-13-8-25/h3-8,12-13,17-18,20-21H,9-11,14-16,19H2,1-2H3,(H,33,35) OCXDHMHFDLCZGZ-UHFFFAOYSA-N 13654 3-Oxybenzamide 40::3-[2-(2,4-dichlorophenyl)ethoxy]-4-(propan-2-yloxy)-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 233 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13654&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052392 46514046 ZINC14953509 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24557 COc1cc(OCCc2ccc(Cl)cc2Cl)cc(c1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H29Cl2N3O3/c1-34-24-14-21(15-25(17-24)35-13-8-20-2-3-22(28)16-26(20)29)27(33)31-18-19-6-11-32(12-7-19)23-4-9-30-10-5-23/h2-5,9-10,14-17,19H,6-8,11-13,18H2,1H3,(H,31,33) SPNXADOKWAUMPQ-UHFFFAOYSA-N 13655 3-Oxybenzamide 41::3-[2-(2,4-dichlorophenyl)ethoxy]-5-methoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 125 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13655&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396232 46514047 ZINC13643394 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24558 COc1cc(cc(OCCc2ccc(Cl)cc2Cl)c1OC)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C28H31Cl2N3O4/c1-35-25-15-21(16-26(27(25)36-2)37-14-9-20-3-4-22(29)17-24(20)30)28(34)32-18-19-7-12-33(13-8-19)23-5-10-31-11-6-23/h3-6,10-11,15-17,19H,7-9,12-14,18H2,1-2H3,(H,32,34) BUHZALANBOOLCL-UHFFFAOYSA-N 13656 3-Oxybenzamide 42::3-[2-(2,4-dichlorophenyl)ethoxy]-4,5-dimethoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 50 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13656&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052319 46514048 ZINC14953514 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24559 CCOc1cc(cc(OCCc2ccc(Cl)cc2Cl)c1OCC)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C30H35Cl2N3O4/c1-3-37-27-17-23(30(36)34-20-21-9-14-35(15-10-21)25-7-12-33-13-8-25)18-28(29(27)38-4-2)39-16-11-22-5-6-24(31)19-26(22)32/h5-8,12-13,17-19,21H,3-4,9-11,14-16,20H2,1-2H3,(H,34,36) APMZHDGXRDMALH-UHFFFAOYSA-N 13657 3-Oxybenzamide 43::3-[2-(2,4-dichlorophenyl)ethoxy]-4,5-diethoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 263 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13657&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052419 46514049 ZINC14953519 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24560 Clc1ccc(CCOc2cc(cc3OCOc23)C(=O)NCC2CCN(CC2)c2ccncc2)c(Cl)c1 InChI=1S/C27H27Cl2N3O4/c28-21-2-1-19(23(29)15-21)7-12-34-24-13-20(14-25-26(24)36-17-35-25)27(33)31-16-18-5-10-32(11-6-18)22-3-8-30-9-4-22/h1-4,8-9,13-15,18H,5-7,10-12,16-17H2,(H,31,33) IDTTVHUXXPGDJV-UHFFFAOYSA-N 13658 3-Oxybenzamide 44::7-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}-2H-1,3-benzodioxole-5-carboxamide Coagulation factor X Homo sapiens 39 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13658&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396298 46514050 ZINC14953525 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24561 COc1cc(cc(OCCc2ccc(Cl)cc2Cl)c1Br)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H28BrCl2N3O3/c1-35-24-14-20(15-25(26(24)28)36-13-8-19-2-3-21(29)16-23(19)30)27(34)32-17-18-6-11-33(12-7-18)22-4-9-31-10-5-22/h2-5,9-10,14-16,18H,6-8,11-13,17H2,1H3,(H,32,34) GJNNFCMJAHQXBR-UHFFFAOYSA-N 13659 3-Oxybenzamide 45::4-bromo-3-[2-(2,4-dichlorophenyl)ethoxy]-5-methoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 20 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13659&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052478 46514051 ZINC03989403 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25668 NC(=[NH2+])c1ccc2[nH]c(cc2c1)-c1cccc(-c2ccccc2)c1[O-] InChI=1S/C21H17N3O/c22-21(23)14-9-10-18-15(11-14)12-19(24-18)17-8-4-7-16(20(17)25)13-5-2-1-3-6-13/h1-12,24-25H,(H3,22,23) GAVRMVQHHVMXFD-UHFFFAOYSA-N 14142 2-{5-[amino(iminiumyl)methyl]-1H-indol-2-yl}-6-phenylbenzen-1-olate::3-{5-[AMINO(IMINIO)METHYL]-1H-INDOL-2-YL}-1,1-BIPHENYL-2-OLATE)::APC-8696::CA-04::CRA-8696 Coagulation factor X Homo sapiens 78 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14142&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 696 1O5A,1O3E,1O3G,1O3F,1O2G 447476 46514500 DB03159 ZINC02047576 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25669 NC(=N)c1ccc2nc([nH]c2c1)-c1cccc(-c2ccccc2)c1O InChI=1S/C20H16N4O/c21-19(22)13-9-10-16-17(11-13)24-20(23-16)15-8-4-7-14(18(15)25)12-5-2-1-3-6-12/h1-11,25H,(H3,21,22)(H,23,24) LMGQGPVCSYOMNS-UHFFFAOYSA-N 14143 2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE::2-(2-hydroxy-3-phenylphenyl)-1H-1,3-benzodiazole-5-carboximidamide::APC-7806::CHEMBL327715 Coagulation factor X Homo sapiens 950 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14143&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1GJ5,1GJB,1GJC,1O39,1O3A,1O3B,1O3C,1O3D 5353305 46514501 CHEMBL327715 ZINC02047577 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25670 NC(=[NH2+])c1ccc2nc([nH]c2c1)-c1cccc(OC2CCCC2)c1[O-] InChI=1S/C19H20N4O2/c20-18(21)11-8-9-14-15(10-11)23-19(22-14)13-6-3-7-16(17(13)24)25-12-4-1-2-5-12/h3,6-10,12,24H,1-2,4-5H2,(H3,20,21)(H,22,23) WCFWDBPDMBXMTQ-UHFFFAOYSA-N 14144 2-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-6-(cyclopentyloxy)benzen-1-olate::APC-10655::CA-06 Coagulation factor X Homo sapiens 1400 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14144&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2I,1O3P 6119062 46514502 ZINC05973961 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25671 CC(C)COc1cccc(-c2nc3ccc(cc3[nH]2)C(N)=[NH2+])c1[O-] InChI=1S/C18H20N4O2/c1-10(2)9-24-15-5-3-4-12(16(15)23)18-21-13-7-6-11(17(19)20)8-14(13)22-18/h3-8,10,23H,9H2,1-2H3,(H3,19,20)(H,21,22) HSHVHNIOQTZSOQ-UHFFFAOYSA-N 14145 2-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-6-(2-methylpropoxy)benzen-1-olate::APC-10656::CA-08 Coagulation factor X Homo sapiens 4600 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14145&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2J,1O2K 6119063 46514503 ZINC13444350 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25672 NC(=[NH2+])c1ccc2[nH]c(cc2c1)-c1cc(Cl)cc(Cl)c1O InChI=1S/C15H11Cl2N3O/c16-9-5-10(14(21)11(17)6-9)13-4-8-3-7(15(18)19)1-2-12(8)20-13/h1-6,20-21H,(H3,18,19)/p+1 AACVRGGQVLDYDM-UHFFFAOYSA-O 14146 APC-9008::{amino[2-(3,5-dichloro-2-hydroxyphenyl)-1H-indol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 70 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14146&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646617 46514504 ZINC14954797 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25673 NC(=[NH2+])c1cc2nc([nH]c2cc1F)-c1cccc(-c2ccccc2)c1O InChI=1S/C20H15FN4O/c21-15-10-17-16(9-14(15)19(22)23)24-20(25-17)13-8-4-7-12(18(13)26)11-5-2-1-3-6-11/h1-10,26H,(H3,22,23)(H,24,25)/p+1 QXRGLPOCPFPVHS-UHFFFAOYSA-O 14147 APC-10818::{amino[6-fluoro-2-(2-hydroxy-3-phenylphenyl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 12000 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14147&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646618 46514505 ZINC14954801 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25674 CC(C)COc1cccc(-c2nc3cc(F)c(cc3[nH]2)C(N)=[NH2+])c1[O-] InChI=1S/C18H19FN4O2/c1-9(2)8-25-15-5-3-4-10(16(15)24)18-22-13-6-11(17(20)21)12(19)7-14(13)23-18/h3-7,9,24H,8H2,1-2H3,(H3,20,21)(H,22,23) NSUDDASMRZSVON-UHFFFAOYSA-N 14148 2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benzodiazol-2-yl}-6-(2-methylpropoxy)benzen-1-olate::APC-10950::CA-10 Coagulation factor X Homo sapiens 31000 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14148&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2O 6102526 46514506 ZINC31270922 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25675 C[C@H]1CCCC[C@@H]1Oc1cccc(-c2cc3cc(C(N)=N)c(F)cc3[nH]2)c1O InChI=1S/C22H24FN3O2/c1-12-5-2-3-7-19(12)28-20-8-4-6-14(21(20)27)18-10-13-9-15(22(24)25)16(23)11-17(13)26-18/h4,6,8-12,19,26-27H,2-3,5,7H2,1H3,(H3,24,25)/t12-,19-/m0/s1 HUYQYLFFFNSAAX-BUXKBTBVSA-N 14149 6-fluoro-2-(2-hydroxy-3-{[(1S,2S)-2-methylcyclohexyl]oxy}phenyl)-1H-indole-5-carboximidamide::APC-11092 Coagulation factor X Homo sapiens 34000 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14149&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 134 1GJ9 445849 46514507 DB06856 ZINC06494961 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25676 NC(=[NH2+])c1cc2cc([nH]c2cc1F)-c1cccc(-c2ccccc2)c1O InChI=1S/C21H16FN3O/c22-17-11-18-13(9-16(17)21(23)24)10-19(25-18)15-8-4-7-14(20(15)26)12-5-2-1-3-6-12/h1-11,25-26H,(H3,23,24)/p+1 NKADRYHVDUCFQU-UHFFFAOYSA-O 14150 APC-11417::CA-12::CRA-11417::{amino[6-fluoro-2-(2-hydroxy-3-phenylphenyl)-1H-indol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 1300 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14150&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646620 46514508 ZINC00025911 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25677 NC(=[NH2+])c1cc2cc([nH]c2cc1Cl)-c1cc(Cl)cc(Cl)c1O InChI=1S/C15H10Cl3N3O/c16-7-3-9(14(22)11(18)4-7)13-2-6-1-8(15(19)20)10(17)5-12(6)21-13/h1-5,21-22H,(H3,19,20)/p+1 BWMVXULSVHMQIK-UHFFFAOYSA-O 14151 APC-9850::{amino[6-chloro-2-(3,5-dichloro-2-hydroxyphenyl)-1H-indol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 4700 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14151&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646621 46514509 ZINC14954805 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25678 NC(=[NH2+])c1cc2cc([nH]c2cc1Cl)-c1cccc(-c2ccccc2)c1O InChI=1S/C21H16ClN3O/c22-17-11-18-13(9-16(17)21(23)24)10-19(25-18)15-8-4-7-14(20(15)26)12-5-2-1-3-6-12/h1-11,25-26H,(H3,23,24)/p+1 FEKRWNWZMOSVBX-UHFFFAOYSA-O 14152 6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE::APC-10302::CA-14::CRA-10302::{amino[6-chloro-2-(2-hydroxy-3-phenylphenyl)-1H-indol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 19000 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14152&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 132 1O5E,1GJ4,1GJ6,1GJ7 445843 46514510 DB03865 ZINC00603005 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25679 NC(=[NH2+])c1cc2[nH]c(nc2cc1Cl)-c1cccc(-c2ccccc2)c1[O-] InChI=1S/C20H15ClN4O/c21-15-10-17-16(9-14(15)19(22)23)24-20(25-17)13-8-4-7-12(18(13)26)11-5-2-1-3-6-11/h1-10,26H,(H3,22,23)(H,24,25) RPGVMAPDADAHPV-UHFFFAOYSA-N 14153 2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-1,3-benzodiazol-2-yl}-6-phenylbenzen-1-olate::APC-10762 Coagulation factor X Homo sapiens 18000 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14153&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2L,1O2M,1O2N 6102594 46514511 ZINC33360149 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25680 CC(C)COc1cccc(-c2nc3cc(Cl)c(cc3[nH]2)C(N)=[NH2+])c1[O-] InChI=1S/C18H19ClN4O2/c1-9(2)8-25-15-5-3-4-10(16(15)24)18-22-13-6-11(17(20)21)12(19)7-14(13)23-18/h3-7,9,24H,8H2,1-2H3,(H3,20,21)(H,22,23) RTSLVPMQUZXPBZ-UHFFFAOYSA-N 14154 2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-1,3-benzodiazol-2-yl}-6-(2-methylpropoxy)benzen-1-olate::APC-10972 Coagulation factor X Homo sapiens 33000 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14154&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2P 6102595 46514512 ZINC33836556 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25681 NC(=N)c1ccc(NC(=O)c2ccccc2O)cc1 InChI=1S/C14H13N3O2/c15-13(16)9-5-7-10(8-6-9)17-14(19)11-3-1-2-4-12(11)18/h1-8,18H,(H3,15,16)(H,17,19) MYHDBRFFPZXDMX-UHFFFAOYSA-N 14155 APC-7136::CHEMBL64708::N-(4-CARBAMIMIDOYL-PHENYL)-2-HYDROXY-BENZAMIDE::N-(4-carbamimidoylphenyl)-2-hydroxybenzamide Coagulation factor X Homo sapiens 24000 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14155&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 135 6QHC,1GJA 4301 46514513 CHEMBL64708 ZINC03591050 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25682 Cc1cc(Br)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N InChI=1S/C15H14BrN3O2/c1-8-6-11(13(20)12(16)7-8)15(21)19-10-4-2-9(3-5-10)14(17)18/h2-7,20H,1H3,(H3,17,18)(H,19,21) LTXLJGIDFWWEQI-UHFFFAOYSA-N 14156 3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-methylbenzamide::APC-10484::CHEMBL61327 Coagulation factor X Homo sapiens 410 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14156&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646622 46514514 CHEMBL61327 ZINC13444423 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25683 Cc1cc(I)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N InChI=1S/C15H14IN3O2/c1-8-6-11(13(20)12(16)7-8)15(21)19-10-4-2-9(3-5-10)14(17)18/h2-7,20H,1H3,(H3,17,18)(H,19,21) JECHDKUWRBFZLB-UHFFFAOYSA-N 14157 APC-10605::CHEMBL64097::N-(4-carbamimidoylphenyl)-2-hydroxy-3-iodo-5-methylbenzamide Coagulation factor X Homo sapiens 2200 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14157&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9886960 46514515 CHEMBL64097 ZINC13444426 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25684 Cc1cc(I)c(O)c(c1)C(=O)Nc1ccc(C(N)=N)c(F)c1 InChI=1S/C15H13FIN3O2/c1-7-4-10(13(21)12(17)5-7)15(22)20-8-2-3-9(14(18)19)11(16)6-8/h2-6,21H,1H3,(H3,18,19)(H,20,22) GDPHNLIBJUAUNC-UHFFFAOYSA-N 14158 APC-11922::CHEMBL293260::N-(4-carbamimidoyl-3-fluorophenyl)-2-hydroxy-3-iodo-5-methylbenzamide Coagulation factor X Homo sapiens 500 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14158&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646623 46514516 CHEMBL293260 ZINC13444429 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25685 Cc1cc(I)c(O)c(c1)C(=O)Nc1ccc(C(N)=N)c(Cl)c1 InChI=1S/C15H13ClIN3O2/c1-7-4-10(13(21)12(17)5-7)15(22)20-8-2-3-9(14(18)19)11(16)6-8/h2-6,21H,1H3,(H3,18,19)(H,20,22) QKGFTDAISIBIBV-UHFFFAOYSA-N 14159 APC-11421::CHEMBL62897::N-(4-carbamimidoyl-3-chlorophenyl)-2-hydroxy-3-iodo-5-methylbenzamide::N-{4-[amino(imino)methyl]-3-chlorophenyl}-2-hydroxy-3-iodo-5-methylbenzamide Coagulation factor X Homo sapiens 110000 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14159&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 136 1GJD 4300 46514517 CHEMBL62897 DB06857 ZINC03591047 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25686 NC(=N)c1ccc2nc([nH]c2c1)-c1cccc(-c2ccccc2)c1O InChI=1S/C20H16N4O/c21-19(22)13-9-10-16-17(11-13)24-20(23-16)15-8-4-7-14(18(15)25)12-5-2-1-3-6-12/h1-11,25H,(H3,21,22)(H,23,24) LMGQGPVCSYOMNS-UHFFFAOYSA-N 14143 2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE::2-(2-hydroxy-3-phenylphenyl)-1H-1,3-benzodiazole-5-carboximidamide::APC-7806::CHEMBL327715 Coagulation factor X Homo sapiens 950 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14143&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1GJ5,1GJB,1GJC,1O39,1O3A,1O3B,1O3C,1O3D 5353305 46514501 CHEMBL327715 ZINC02047577 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25687 CC(C)COc1cccc(-c2nc3ccc(cc3[nH]2)C(N)=[NH2+])c1[O-] InChI=1S/C18H20N4O2/c1-10(2)9-24-15-5-3-4-12(16(15)23)18-21-13-7-6-11(17(19)20)8-14(13)22-18/h3-8,10,23H,9H2,1-2H3,(H3,19,20)(H,21,22) HSHVHNIOQTZSOQ-UHFFFAOYSA-N 14145 2-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-6-(2-methylpropoxy)benzen-1-olate::APC-10656::CA-08 Coagulation factor X Homo sapiens 3400 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14145&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2J,1O2K 6119063 46514503 ZINC13444350 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25688 NC(=[NH2+])c1cc2nc([nH]c2cc1F)-c1cccc(-c2ccccc2)c1O InChI=1S/C20H15FN4O/c21-15-10-17-16(9-14(15)19(22)23)24-20(25-17)13-8-4-7-12(18(13)26)11-5-2-1-3-6-11/h1-10,26H,(H3,22,23)(H,24,25)/p+1 QXRGLPOCPFPVHS-UHFFFAOYSA-O 14147 APC-10818::{amino[6-fluoro-2-(2-hydroxy-3-phenylphenyl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 37000 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14147&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646618 46514505 ZINC14954801 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25689 CC(C)COc1cccc(-c2nc3cc(F)c(cc3[nH]2)C(N)=[NH2+])c1[O-] InChI=1S/C18H19FN4O2/c1-9(2)8-25-15-5-3-4-10(16(15)24)18-22-13-6-11(17(20)21)12(19)7-14(13)23-18/h3-7,9,24H,8H2,1-2H3,(H3,20,21)(H,22,23) NSUDDASMRZSVON-UHFFFAOYSA-N 14148 2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benzodiazol-2-yl}-6-(2-methylpropoxy)benzen-1-olate::APC-10950::CA-10 Coagulation factor X Homo sapiens >450000 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14148&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2O 6102526 46514506 ZINC31270922 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25690 C[C@H]1CCCC[C@@H]1Oc1cccc(-c2cc3cc(C(N)=N)c(F)cc3[nH]2)c1O InChI=1S/C22H24FN3O2/c1-12-5-2-3-7-19(12)28-20-8-4-6-14(21(20)27)18-10-13-9-15(22(24)25)16(23)11-17(13)26-18/h4,6,8-12,19,26-27H,2-3,5,7H2,1H3,(H3,24,25)/t12-,19-/m0/s1 HUYQYLFFFNSAAX-BUXKBTBVSA-N 14149 6-fluoro-2-(2-hydroxy-3-{[(1S,2S)-2-methylcyclohexyl]oxy}phenyl)-1H-indole-5-carboximidamide::APC-11092 Coagulation factor X Homo sapiens 25000 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14149&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 134 1GJ9 445849 46514507 DB06856 ZINC06494961 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25691 NC(=[NH2+])c1cc2[nH]c(nc2cc1Cl)-c1cccc(-c2ccccc2)c1[O-] InChI=1S/C20H15ClN4O/c21-15-10-17-16(9-14(15)19(22)23)24-20(25-17)13-8-4-7-12(18(13)26)11-5-2-1-3-6-11/h1-10,26H,(H3,22,23)(H,24,25) RPGVMAPDADAHPV-UHFFFAOYSA-N 14153 2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-1,3-benzodiazol-2-yl}-6-phenylbenzen-1-olate::APC-10762 Coagulation factor X Homo sapiens 50000 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14153&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2L,1O2M,1O2N 6102594 46514511 ZINC33360149 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25692 CC(C)COc1cccc(-c2nc3cc(Cl)c(cc3[nH]2)C(N)=[NH2+])c1[O-] InChI=1S/C18H19ClN4O2/c1-9(2)8-25-15-5-3-4-10(16(15)24)18-22-13-6-11(17(20)21)12(19)7-14(13)23-18/h3-7,9,24H,8H2,1-2H3,(H3,20,21)(H,22,23) RTSLVPMQUZXPBZ-UHFFFAOYSA-N 14154 2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-1,3-benzodiazol-2-yl}-6-(2-methylpropoxy)benzen-1-olate::APC-10972 Coagulation factor X Homo sapiens 55000 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14154&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2P 6102595 46514512 ZINC33836556 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25693 NC(=N)c1ccc2nc([nH]c2c1)-c1cccc(-c2ccccc2)c1O InChI=1S/C20H16N4O/c21-19(22)13-9-10-16-17(11-13)24-20(23-16)15-8-4-7-14(18(15)25)12-5-2-1-3-6-12/h1-11,25H,(H3,21,22)(H,23,24) LMGQGPVCSYOMNS-UHFFFAOYSA-N 14143 2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE::2-(2-hydroxy-3-phenylphenyl)-1H-1,3-benzodiazole-5-carboximidamide::APC-7806::CHEMBL327715 Coagulation factor X Homo sapiens 430 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14143&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1GJ5,1GJB,1GJC,1O39,1O3A,1O3B,1O3C,1O3D 5353305 46514501 CHEMBL327715 ZINC02047577 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25694 CC(C)COc1cccc(-c2nc3ccc(cc3[nH]2)C(N)=[NH2+])c1[O-] InChI=1S/C18H20N4O2/c1-10(2)9-24-15-5-3-4-12(16(15)23)18-21-13-7-6-11(17(19)20)8-14(13)22-18/h3-8,10,23H,9H2,1-2H3,(H3,19,20)(H,21,22) HSHVHNIOQTZSOQ-UHFFFAOYSA-N 14145 2-{5-[amino(iminiumyl)methyl]-1H-1,3-benzodiazol-2-yl}-6-(2-methylpropoxy)benzen-1-olate::APC-10656::CA-08 Coagulation factor X Homo sapiens 370 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14145&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2J,1O2K 6119063 46514503 ZINC13444350 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25695 NC(=[NH2+])c1cc2nc([nH]c2cc1F)-c1cccc(-c2ccccc2)c1O InChI=1S/C20H15FN4O/c21-15-10-17-16(9-14(15)19(22)23)24-20(25-17)13-8-4-7-12(18(13)26)11-5-2-1-3-6-11/h1-10,26H,(H3,22,23)(H,24,25)/p+1 QXRGLPOCPFPVHS-UHFFFAOYSA-O 14147 APC-10818::{amino[6-fluoro-2-(2-hydroxy-3-phenylphenyl)-1H-1,3-benzodiazol-5-yl]methylidene}azanium Coagulation factor X Homo sapiens 2600 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14147&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646618 46514505 ZINC14954801 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25696 CC(C)COc1cccc(-c2nc3cc(F)c(cc3[nH]2)C(N)=[NH2+])c1[O-] InChI=1S/C18H19FN4O2/c1-9(2)8-25-15-5-3-4-10(16(15)24)18-22-13-6-11(17(20)21)12(19)7-14(13)23-18/h3-7,9,24H,8H2,1-2H3,(H3,20,21)(H,22,23) NSUDDASMRZSVON-UHFFFAOYSA-N 14148 2-{5-[amino(iminiumyl)methyl]-6-fluoro-1H-1,3-benzodiazol-2-yl}-6-(2-methylpropoxy)benzen-1-olate::APC-10950::CA-10 Coagulation factor X Homo sapiens 1700 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14148&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2O 6102526 46514506 ZINC31270922 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25697 C[C@H]1CCCC[C@@H]1Oc1cccc(-c2cc3cc(C(N)=N)c(F)cc3[nH]2)c1O InChI=1S/C22H24FN3O2/c1-12-5-2-3-7-19(12)28-20-8-4-6-14(21(20)27)18-10-13-9-15(22(24)25)16(23)11-17(13)26-18/h4,6,8-12,19,26-27H,2-3,5,7H2,1H3,(H3,24,25)/t12-,19-/m0/s1 HUYQYLFFFNSAAX-BUXKBTBVSA-N 14149 6-fluoro-2-(2-hydroxy-3-{[(1S,2S)-2-methylcyclohexyl]oxy}phenyl)-1H-indole-5-carboximidamide::APC-11092 Coagulation factor X Homo sapiens 1200 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14149&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 134 1GJ9 445849 46514507 DB06856 ZINC06494961 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25698 NC(=[NH2+])c1cc2[nH]c(nc2cc1Cl)-c1cccc(-c2ccccc2)c1[O-] InChI=1S/C20H15ClN4O/c21-15-10-17-16(9-14(15)19(22)23)24-20(25-17)13-8-4-7-12(18(13)26)11-5-2-1-3-6-11/h1-10,26H,(H3,22,23)(H,24,25) RPGVMAPDADAHPV-UHFFFAOYSA-N 14153 2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-1,3-benzodiazol-2-yl}-6-phenylbenzen-1-olate::APC-10762 Coagulation factor X Homo sapiens 21000 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14153&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2L,1O2M,1O2N 6102594 46514511 ZINC33360149 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25699 CC(C)COc1cccc(-c2nc3cc(Cl)c(cc3[nH]2)C(N)=[NH2+])c1[O-] InChI=1S/C18H19ClN4O2/c1-9(2)8-25-15-5-3-4-10(16(15)24)18-22-13-6-11(17(20)21)12(19)7-14(13)23-18/h3-7,9,24H,8H2,1-2H3,(H3,20,21)(H,22,23) RTSLVPMQUZXPBZ-UHFFFAOYSA-N 14154 2-{5-[amino(iminiumyl)methyl]-6-chloro-1H-1,3-benzodiazol-2-yl}-6-(2-methylpropoxy)benzen-1-olate::APC-10972 Coagulation factor X Homo sapiens 4300 Curated from the literature by BindingDB 10.1016/S1074-5521(01)00084-9 10.7270/Q2S75DKN 11731301 aid1797164 Katz, BA; Sprengeler, PA; Luong, C; Verner, E; Elrod, K; Kirtley, M; Janc, J; Spencer, JR; Breitenbucher, JG; Hui, H; McGee, D; Allen, D; Martelli, A; Mackman, RL Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14154&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1O2P 6102595 46514512 ZINC33836556 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25700 NC(=[NH2+])c1cc2c(I)cccc2s1 InChI=1S/C9H7IN2S/c10-6-2-1-3-7-5(6)4-8(13-7)9(11)12/h1-4H,(H3,11,12)/p+1 YERQOXAYAFWFEJ-UHFFFAOYSA-O 14169 4-Iodobenzo[b]thiophene-2-carboxamidine::APC-6860::CA-01::CRA-6860::[amino(4-iodo-1-benzothiophen-2-yl)methylidene]azanium Coagulation factor X Homo sapiens 30000 7.4 22.00 C Curated from the literature by BindingDB 10.1016/S1074-5521(00)00104-6 10.7270/Q2NG4NWC 10779411 aid1797179 Katz, BA; Mackman, R; Luong, C; Radika, K; Martelli, A; Sprengeler, PA; Wang, J; Chan, H; Wong, L Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14169&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search ESI 1O5B,1C5N,1C5X,1C5R,1C5Q,1C5W 1746 46509438 DB03136 ZINC00017086 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25701 NC(=[NH2+])c1cc2ccccc2s1 InChI=1S/C9H8N2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5H,(H3,10,11)/p+1 JZWDLUGQTRKBNA-UHFFFAOYSA-O 14170 APC-7377::Benzo[b]thiophene-2-carboxamidine::[amino(1-benzothiophen-2-yl)methylidene]azanium Coagulation factor X Homo sapiens 21000 7.4 22.00 C Curated from the literature by BindingDB 10.1016/S1074-5521(00)00104-6 10.7270/Q2NG4NWC 10779411 aid1797179 Katz, BA; Mackman, R; Luong, C; Radika, K; Martelli, A; Sprengeler, PA; Wang, J; Chan, H; Wong, L Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14170&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search ESX 1C5S 444753 46514518 DB04446 ZINC02047300 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25702 NC(=[NH2+])c1cc2cccnc2s1 InChI=1S/C8H7N3S/c9-7(10)6-4-5-2-1-3-11-8(5)12-6/h1-4H,(H3,9,10)/p+1 GZEJMYFXZMUAEC-UHFFFAOYSA-O 14171 APC-7538::Thieno[2,3-b]pyridine-2-carboxamidine::[amino(thieno[2,3-b]pyridin-2-yl)methylidene]azanium Coagulation factor X Homo sapiens 360000 7.4 22.00 C Curated from the literature by BindingDB 10.1016/S1074-5521(00)00104-6 10.7270/Q2NG4NWC 10779411 aid1797179 Katz, BA; Mackman, R; Luong, C; Radika, K; Martelli, A; Sprengeler, PA; Wang, J; Chan, H; Wong, L Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14171&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search ESP 1C5Y,1C5U,1C5T 5438 46514519 DB03876 ZINC02047299 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 25703 NC(=[NH2+])c1ccccc1 InChI=1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9)/p+1 PXXJHWLDUBFPOL-UHFFFAOYSA-O 772 Benzamidine::CHEMBL79897::[amino(phenyl)methylidene]azanium::benzamidine deriv.::benzamidinium chloride Coagulation factor X Homo sapiens 110000 7.4 22.00 C Curated from the literature by BindingDB 10.1016/S1074-5521(00)00104-6 10.7270/Q2NG4NWC 10779411 aid1797179 Katz, BA; Mackman, R; Luong, C; Radika, K; Martelli, A; Sprengeler, PA; Wang, J; Chan, H; Wong, L Axys Pharmaceutical http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=772&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search BAM 5AUI,1C5O,1C5Z,1C5P,5Z87,5YX6,3PCZ,5NVJ,3PVK,4OMR,5MOQ,6JO2,1TIO,4J2S,5MNH,5MNG,4IZX,6I44,5MO0,1ZVW,6S32,1HJ8,6Q39,6Q37,1XX4,2PSM,1F5K,4XN6,5JD4,4P9H,5PB1,2BY9,2BY8,2BY7,2BY6,2BY5,2BYA,1C1N,2ANW,2ANY 444655 11108095 41033 CHEMBL79897 DB03127 C01784 ZINC00036634 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23340 CC(C)C[C@H](NC(=O)NCc1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C31H44Cl2N8O4S/c1-18(2)15-24(40-31(45)38-17-19-10-11-21(32)22(33)16-19)27(43)41-25(20-7-4-3-5-8-20)28(44)39-23(9-6-12-37-30(34)35)26(42)29-36-13-14-46-29/h10-11,13-14,16,18,20,23-25H,3-9,12,15,17H2,1-2H3,(H,39,44)(H,41,43)(H4,34,35,37)(H2,38,40,45)/t23-,24-,25-/m0/s1 DUAICTIIBXCAAZ-SDHOMARFSA-N 12958 (2S)-N-[(S)-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}(cyclohexyl)methyl]-2-({[(3,4-dichlorophenyl)methyl]carbamoyl}amino)-4-methylpentanamide::alpha-ketothiazole analogue 18 Coagulation factor X Homo sapiens >200000 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12958&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098896 46512946 ZINC37868459 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23341 CC(C)C[C@H](NC(=O)NCc1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C32H40Cl2N8O4S/c1-19(2)15-25(42-32(46)39-18-21-10-11-22(33)23(34)16-21)28(44)41-26(17-20-7-4-3-5-8-20)29(45)40-24(9-6-12-38-31(35)36)27(43)30-37-13-14-47-30/h3-5,7-8,10-11,13-14,16,19,24-26H,6,9,12,15,17-18H2,1-2H3,(H,40,45)(H,41,44)(H4,35,36,38)(H2,39,42,46)/t24-,25-,26-/m0/s1 AFEHWDXGHZSXGW-GSDHBNRESA-N 12959 (2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-phenylethyl]-2-({[(3,4-dichlorophenyl)methyl]carbamoyl}amino)-4-methylpentanamide::alpha-ketothiazole analogue 19 Coagulation factor X Homo sapiens 8500 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12959&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098897 46509410 ZINC34689247 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23342 CC(C)C[C@H](NC(=O)NCc1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C26H36Cl2N8O4S/c1-14(2)11-20(36-26(40)33-13-16-6-7-17(27)18(28)12-16)23(39)34-15(3)22(38)35-19(5-4-8-32-25(29)30)21(37)24-31-9-10-41-24/h6-7,9-10,12,14-15,19-20H,4-5,8,11,13H2,1-3H3,(H,34,39)(H,35,38)(H4,29,30,32)(H2,33,36,40)/t15-,19-,20-/m0/s1 QIEQHELVMOSWLZ-YSSFQJQWSA-N 12960 (2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}ethyl]-2-({[(3,4-dichlorophenyl)methyl]carbamoyl}amino)-4-methylpentanamide::alpha-ketothiazole analogue 20 Coagulation factor X Homo sapiens 22000 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12960&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098898 46513394 ZINC14951597 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23343 CC(C)C[C@H](NC(=O)NCc1ccc(Cl)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1)C(C)(C)C InChI=1S/C29H42Cl2N8O4S/c1-16(2)13-21(38-28(43)36-15-17-8-9-18(30)19(31)14-17)24(41)39-23(29(3,4)5)25(42)37-20(7-6-10-35-27(32)33)22(40)26-34-11-12-44-26/h8-9,11-12,14,16,20-21,23H,6-7,10,13,15H2,1-5H3,(H,37,42)(H,39,41)(H4,32,33,35)(H2,36,38,43)/t20-,21-,23+/m0/s1 QKIKHWOCEVLRKJ-QNWVGRARSA-N 12961 (2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2,2-dimethylpropyl]-2-({[(3,4-dichlorophenyl)methyl]carbamoyl}amino)-4-methylpentanamide::alpha-ketothiazole analogue 21 Coagulation factor X Homo sapiens >200000 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12961&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098899 46513395 ZINC37868460 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23344 CC(C)C[C@H](NC(=O)NC(C)c1ccc(Br)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C29H43BrN8O4S/c1-16(2)15-22(37-29(42)35-18(5)19-8-10-20(30)11-9-19)25(40)38-23(17(3)4)26(41)36-21(7-6-12-34-28(31)32)24(39)27-33-13-14-43-27/h8-11,13-14,16-18,21-23H,6-7,12,15H2,1-5H3,(H,36,41)(H,38,40)(H4,31,32,34)(H2,35,37,42)/t18?,21-,22-,23-/m0/s1 GPZZZKGHNBJWKG-VPEKBSMISA-N 12962 (2S)-2-({[1-(4-bromophenyl)ethyl]carbamoyl}amino)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-methylpropyl]-4-methylpentanamide::alpha-ketothiazole analogue 22 Coagulation factor X Homo sapiens 15000 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12962&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098900 46513396 ZINC37868462 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23345 CC(C)C[C@H](NC(=O)NCc1ccc(Cl)cc1Cl)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C28H40Cl2N8O4S/c1-15(2)12-21(37-28(42)35-14-17-7-8-18(29)13-19(17)30)24(40)38-22(16(3)4)25(41)36-20(6-5-9-34-27(31)32)23(39)26-33-10-11-43-26/h7-8,10-11,13,15-16,20-22H,5-6,9,12,14H2,1-4H3,(H,36,41)(H,38,40)(H4,31,32,34)(H2,35,37,42)/t20-,21-,22-/m0/s1 NNDYJWLIXNEDOW-FKBYEOEOSA-N 12963 (2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-methylpropyl]-2-({[(2,4-dichlorophenyl)methyl]carbamoyl}amino)-4-methylpentanamide::alpha-ketothiazole analogue 23 Coagulation factor X Homo sapiens 13000 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12963&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098901 46513397 ZINC29125516 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23346 CC(C)C[C@H](NC(=O)NCc1ccc(F)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C28H41FN8O4S/c1-16(2)14-21(36-28(41)34-15-18-7-9-19(29)10-8-18)24(39)37-22(17(3)4)25(40)35-20(6-5-11-33-27(30)31)23(38)26-32-12-13-42-26/h7-10,12-13,16-17,20-22H,5-6,11,14-15H2,1-4H3,(H,35,40)(H,37,39)(H4,30,31,33)(H2,34,36,41)/t20-,21-,22-/m0/s1 CFOZOOXNCIABHM-FKBYEOEOSA-N 12964 (2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-methylpropyl]-2-({[(4-fluorophenyl)methyl]carbamoyl}amino)-4-methylpentanamide::alpha-ketothiazole analogue 24 Coagulation factor X Homo sapiens >20000 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12964&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098902 46513398 ZINC14951602 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23347 CC(C)C[C@H](NC(=O)NCc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C28H42N8O4S/c1-17(2)15-21(35-28(40)33-16-19-9-6-5-7-10-19)24(38)36-22(18(3)4)25(39)34-20(11-8-12-32-27(29)30)23(37)26-31-13-14-41-26/h5-7,9-10,13-14,17-18,20-22H,8,11-12,15-16H2,1-4H3,(H,34,39)(H,36,38)(H4,29,30,32)(H2,33,35,40)/t20-,21-,22-/m0/s1 RLDZHJFLIIOAIL-FKBYEOEOSA-N 12965 (2S)-2-[(benzylcarbamoyl)amino]-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-methylpropyl]-4-methylpentanamide::alpha-ketothiazole analogue 25 Coagulation factor X Homo sapiens >20000 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12965&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098903 46513399 ZINC14951607 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23348 CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C22H37N7O4S/c1-12(2)11-16(27-14(5)30)19(32)29-17(13(3)4)20(33)28-15(7-6-8-26-22(23)24)18(31)21-25-9-10-34-21/h9-10,12-13,15-17H,6-8,11H2,1-5H3,(H,27,30)(H,28,33)(H,29,32)(H4,23,24,26)/t15-,16-,17-/m0/s1 SKYPFUKXJFBSJN-ULQDDVLXSA-N 12967 (2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-methylpropyl]-2-acetamido-4-methylpentanamide::alpha-ketothiazole analogue 27 Coagulation factor X Homo sapiens >200000 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12967&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098905 46513401 ZINC14951619 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23349 CC(C)[C@H](NC(=O)[C@@H](NC(=O)N[C@H](C)c1ccc(Br)cc1)C1CCCCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C31H45BrN8O4S/c1-18(2)24(27(42)38-23(10-7-15-36-30(33)34)26(41)29-35-16-17-45-29)39-28(43)25(21-8-5-4-6-9-21)40-31(44)37-19(3)20-11-13-22(32)14-12-20/h11-14,16-19,21,23-25H,4-10,15H2,1-3H3,(H,38,42)(H,39,43)(H4,33,34,36)(H2,37,40,44)/t19-,23+,24+,25+/m1/s1 OLQGYESZUNMFCC-RYCFVGSHSA-N 12968 (2S)-2-[(2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carbamoyl}amino)-2-cyclohexylacetamido]-N-[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-3-methylbutanamide::alpha-ketothiazole analogue 28 Coagulation factor X Homo sapiens 2700 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12968&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098906 46512947 ZINC34689248 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23350 CC(C)[C@H](NC(=O)[C@@H](NC(=O)N[C@@H](C)c1ccc(Br)cc1)C1CCCCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C31H45BrN8O4S/c1-18(2)24(27(42)38-23(10-7-15-36-30(33)34)26(41)29-35-16-17-45-29)39-28(43)25(21-8-5-4-6-9-21)40-31(44)37-19(3)20-11-13-22(32)14-12-20/h11-14,16-19,21,23-25H,4-10,15H2,1-3H3,(H,38,42)(H,39,43)(H4,33,34,36)(H2,37,40,44)/t19-,23-,24-,25-/m0/s1 OLQGYESZUNMFCC-KMAVCZJNSA-N 12969 (2S)-2-[(2S)-2-({[(1S)-1-(4-bromophenyl)ethyl]carbamoyl}amino)-2-cyclohexylacetamido]-N-[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-3-methylbutanamide::alpha-ketothiazole analogue 29 Coagulation factor X Homo sapiens 14900 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12969&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098907 46512948 ZINC37868463 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23351 CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)N[C@H](C)c1ccc(Br)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C32H41BrN8O5S/c1-18(2)26(29(45)39-24(5-4-14-37-31(34)35)27(43)30-36-15-16-47-30)41-28(44)25(17-20-6-12-23(42)13-7-20)40-32(46)38-19(3)21-8-10-22(33)11-9-21/h6-13,15-16,18-19,24-26,42H,4-5,14,17H2,1-3H3,(H,39,45)(H,41,44)(H4,34,35,37)(H2,38,40,46)/t19-,24+,25+,26+/m1/s1 XOPHHKQWDWBCDG-DCSNJQJVSA-N 12972 (2S)-2-[(2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carbamoyl}amino)-3-(4-hydroxyphenyl)propanamido]-N-[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-3-methylbutanamide::alpha-ketothiazole analogue 32 Coagulation factor X Homo sapiens 1600 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12972&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098910 46509411 ZINC29125472 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23352 CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)N[C@H](C)c1ccc(Br)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C29H44BrN11O4S/c1-16(2)22(25(44)39-20(6-4-12-36-27(31)32)23(42)26-35-14-15-46-26)41-24(43)21(7-5-13-37-28(33)34)40-29(45)38-17(3)18-8-10-19(30)11-9-18/h8-11,14-17,20-22H,4-7,12-13H2,1-3H3,(H,39,44)(H,41,43)(H4,31,32,36)(H4,33,34,37)(H2,38,40,45)/t17-,20+,21+,22+/m1/s1 WBAKUPSUHRKONA-MNAPGUCWSA-N 12973 (2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carbamoyl}amino)-5-carbamimidamido-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-methylpropyl]pentanamide::alpha-ketothiazole analogue 33 Coagulation factor X Homo sapiens 250 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12973&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098911 46509412 ZINC34689249 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23353 CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)N[C@H](C)c1ccc(Br)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C27H38BrN9O5S/c1-14(2)21(24(41)35-18(5-4-10-33-26(30)31)22(39)25-32-11-12-43-25)37-23(40)19(13-20(29)38)36-27(42)34-15(3)16-6-8-17(28)9-7-16/h6-9,11-12,14-15,18-19,21H,4-5,10,13H2,1-3H3,(H2,29,38)(H,35,41)(H,37,40)(H4,30,31,33)(H2,34,36,42)/t15-,18+,19+,21+/m1/s1 MGDHZAAGZWEIJU-CCMRYFRJSA-N 12974 (2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carbamoyl}amino)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-methylpropyl]butanediamide::alpha-ketothiazole analogue 34 Coagulation factor X Homo sapiens 1600 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12974&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098912 46513406 ZINC34689250 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23354 CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N[C@H](C)c1ccc(Br)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C34H42BrN9O4S/c1-19(2)28(31(47)42-26(9-6-14-39-33(36)37)29(45)32-38-15-16-49-32)44-30(46)27(17-22-18-40-25-8-5-4-7-24(22)25)43-34(48)41-20(3)21-10-12-23(35)13-11-21/h4-5,7-8,10-13,15-16,18-20,26-28,40H,6,9,14,17H2,1-3H3,(H,42,47)(H,44,46)(H4,36,37,39)(H2,41,43,48)/t20-,26+,27+,28+/m1/s1 RXTVQIZDVTYZLH-DLMOMKDTSA-N 12975 (2S)-2-[(2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carbamoyl}amino)-3-(1H-indol-3-yl)propanamido]-N-[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-3-methylbutanamide::alpha-ketothiazole analogue 35 Coagulation factor X Homo sapiens 2100 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12975&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16098913 46509413 ZINC95543520 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23355 CC(C)[C@H](NC(=O)[C@H](CCCNC(N)=O)NC(=O)N[C@H](C)c1ccc(Br)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C29H43BrN10O5S/c1-16(2)22(25(43)38-20(6-4-12-35-27(31)32)23(41)26-34-14-15-46-26)40-24(42)21(7-5-13-36-28(33)44)39-29(45)37-17(3)18-8-10-19(30)11-9-18/h8-11,14-17,20-22H,4-7,12-13H2,1-3H3,(H,38,43)(H,40,42)(H4,31,32,35)(H3,33,36,44)(H2,37,39,45)/t17-,20+,21+,22+/m1/s1 BGBJLVHKOHYLME-MNAPGUCWSA-N 12976 (2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carbamoyl}amino)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]carbamoyl}-2-methylpropyl]-5-(carbamoylamino)pentanamide::alpha-ketothiazole analogue 36 Coagulation factor X Homo sapiens 1900 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12976&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1ZOM 16098914 46509414 6549 C03022 ZINC29125473 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23356 CC(C)[C@H](NC(=O)[C@H](Cc1cccnc1)NC(=O)N[C@H](C)c1ccc(Br)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)c1nccs1 InChI=1S/C31H40BrN9O4S/c1-18(2)25(28(44)39-23(7-5-13-37-30(33)34)26(42)29-36-14-15-46-29)41-27(43)24(16-20-6-4-12-35-17-20)40-31(45)38-19(3)21-8-10-22(32)11-9-21/h4,6,8-12,14-15,17-19,23-25H,5,7,13,16H2,1-3H3,(H,39,44)(H,41,43)(H4,33,34,37)(H2,38,40,45)/t19-,23+,24+,25+/m1/s1 UDBRERAFHAOQBV-RYCFVGSHSA-N 12977 (2S)-2-[(2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carbamoyl}amino)-3-(pyridin-3-yl)propanamido]-N-[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-3-methylbutanamide::alpha-ketothiazole analogue 37 Coagulation factor X Homo sapiens 1400 Curated from the literature by BindingDB 10.1021/jm060978s 10.7270/Q2SJ1HTM 17181160 aid1796967 Lin, J; Deng, H; Jin, L; Pandey, P; Quinn, J; Cantin, S; Rynkiewicz, MJ; Gorga, JC; Bibbins, F; Celatka, CA; Nagafuji, P; Bannister, TD; Meyers, HV; Babine, RE; Hayward, NJ; Weaver, D; Benjamin, H; Stassen, F; Abdel-Meguid, SS; Strickler, JE Daiichi Asubio Medical Research Laboratories, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12977&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11399867 46513408 ZINC34689251 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23399 Fc1cc(ccc1N1CCSCC1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C19H19ClFN3O3S2/c20-17-4-3-16(29-17)18(25)22-10-13-11-24(19(26)27-13)12-1-2-15(14(21)9-12)23-5-7-28-8-6-23/h1-4,9,13H,5-8,10-11H2,(H,22,25)/t13-/m0/s1 UDUYCVOUOVCOFL-ZDUSSCGKSA-N 12988 5-Chloro-N-{[(5S)-3-(3-fluoro-4-thiomorpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide::5-chloro-N-{[(5S)-3-[3-fluoro-4-(thiomorpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide::BAY 59-7939 Analog 4 Coagulation factor X Homo sapiens 90 8.3 25.00 C Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12988&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10161422 46513415 ZINC13673217 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23400 Fc1cc(ccc1N1CCOCC1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C19H19ClFN3O4S/c20-17-4-3-16(29-17)18(25)22-10-13-11-24(19(26)28-13)12-1-2-15(14(21)9-12)23-5-7-27-8-6-23/h1-4,9,13H,5-8,10-11H2,(H,22,25)/t13-/m0/s1 MAOZUYDDGGFCKF-ZDUSSCGKSA-N 12990 5-Chloro-N-{[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide::5-chloro-N-{[(5S)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide::BAY 59-7939 Analog 6 Coagulation factor X Homo sapiens 32 8.3 25.00 C Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12990&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10138114 46513416 ZINC13673218 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23401 Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1 InChI=1S/C19H20ClN3O4S/c20-17-6-5-16(28-17)18(24)21-11-15-12-23(19(25)27-15)14-3-1-13(2-4-14)22-7-9-26-10-8-22/h1-6,15H,7-12H2,(H,21,24)/t15-/m0/s1 KLGDIFUIQLJAAR-HNNXBMFYSA-N 7495 BAY 59-7939 Analog 7::US8822458, 2 Coagulation factor X Homo sapiens 43 8.3 25.00 C Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7495&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10273747 242052774 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23402 Fc1cc(ccc1N1CCCC1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C19H19ClFN3O3S/c20-17-6-5-16(28-17)18(25)22-10-13-11-24(19(26)27-13)12-3-4-15(14(21)9-12)23-7-1-2-8-23/h3-6,9,13H,1-2,7-8,10-11H2,(H,22,25)/t13-/m0/s1 KUPKOIOPQVEAPX-ZDUSSCGKSA-N 12992 5-Chloro-N-{[(5S)-3-(3-fluoro-4-pyrrolidin-1-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide::5-chloro-N-{[(5S)-3-[3-fluoro-4-(pyrrolidin-1-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide::BAY 59-7939 Analog 8 Coagulation factor X Homo sapiens 40 8.3 25.00 C Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12992&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11553603 46513418 ZINC12354974 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23403 CN(C)c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C17H18ClN3O3S/c1-20(2)11-3-5-12(6-4-11)21-10-13(24-17(21)23)9-19-16(22)14-7-8-15(18)25-14/h3-8,13H,9-10H2,1-2H3,(H,19,22)/t13-/m0/s1 SDPNOIGDWTUQEV-ZDUSSCGKSA-N 12993 5-Chloro-N-({(5S)-3-[4-(dimethylamino)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide::5-chloro-N-{[(5S)-3-[4-(dimethylamino)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide::BAY 59-7939 Analog 9::US8822458, 49 Coagulation factor X Homo sapiens 74 8.3 25.00 C Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12993&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11523750 46513419 ZINC12354881 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23404 Fc1cc(ccc1N1CCNCC1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C19H20ClFN4O3S/c20-17-4-3-16(29-17)18(26)23-10-13-11-25(19(27)28-13)12-1-2-15(14(21)9-12)24-7-5-22-6-8-24/h1-4,9,13,22H,5-8,10-11H2,(H,23,26)/t13-/m0/s1 RCVMZVZBCGIKNQ-ZDUSSCGKSA-N 7532 BAY 59-7939 Analog 10::US8822458, 11 Coagulation factor X Homo sapiens 140 8.3 25.00 C Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7532&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10274887 242052775 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23405 Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCCC1=O InChI=1S/C19H18ClN3O4S/c20-16-8-7-15(28-16)18(25)21-10-14-11-23(19(26)27-14)13-5-3-12(4-6-13)22-9-1-2-17(22)24/h3-8,14H,1-2,9-11H2,(H,21,25)/t14-/m0/s1 CWYUNIAGLBIPIP-AWEZNQCLSA-N 7552 BAY 59-7939 Analog 11::US8822458, 17 Coagulation factor X Homo sapiens 4.0 8.3 25.00 C Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7552&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10202260 242052776 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23406 Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1 KGFYHTZWPPHNLQ-AWEZNQCLSA-N 7840 RIVAROXABAN::US8822458, 44::US8822458, 97 Coagulation factor X Homo sapiens 0.7 8.3 25.00 C Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7840&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search RIV 5VOF,2W26 9875401 242052786 DB08477 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23407 Fc1cc(ccc1N1CCOCC1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C19H17ClFN3O5S/c20-16-4-3-15(30-16)18(26)22-8-12-9-24(19(27)29-12)11-1-2-14(13(21)7-11)23-5-6-28-10-17(23)25/h1-4,7,12H,5-6,8-10H2,(H,22,26)/t12-/m0/s1 XVBPEQFOAPLQGK-LBPRGKRZSA-N 12997 5-Chloro-N-({(5S)-3-[3-fluoro-4-(3-oxomorpholin-4-yl)-phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide::5-chloro-N-{[(5S)-3-[3-fluoro-4-(3-oxomorpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide::BAY 59-7939 Analog 12 Coagulation factor X Homo sapiens 1.4 8.3 25.00 C Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12997&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11525292 46513423 ZINC13673225 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23408 FC(F)(F)c1cc(ccc1N1CCOCC1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C20H17ClF3N3O5S/c21-16-4-3-15(33-16)18(29)25-8-12-9-27(19(30)32-12)11-1-2-14(13(7-11)20(22,23)24)26-5-6-31-10-17(26)28/h1-4,7,12H,5-6,8-10H2,(H,25,29)/t12-/m0/s1 DRBHMPWPYAXXIX-LBPRGKRZSA-N 12998 5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)-3-(trifluoromethyl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide::5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)-3-(trifluoromethyl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide::BAY 59-7939 Analog 13 Coagulation factor X Homo sapiens 1.0 8.3 25.00 C Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12998&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11562451 46513424 ZINC13673227 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23409 Nc1cc(ccc1N1CCOCC1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C19H19ClN4O5S/c20-16-4-3-15(30-16)18(26)22-8-12-9-24(19(27)29-12)11-1-2-14(13(21)7-11)23-5-6-28-10-17(23)25/h1-4,7,12H,5-6,8-10,21H2,(H,22,26)/t12-/m0/s1 INLXEGDYWOAZAA-LBPRGKRZSA-N 12999 BAY 59-7939 Analog 14::N-({(5S)-3-[3-Amino-4-(3-oxomorpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)-5-chlorothiophene-2-carboxamide::N-{[(5S)-3-[3-amino-4-(3-oxomorpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl}-5-chlorothiophene-2-carboxamide Coagulation factor X Homo sapiens 2.5 8.3 25.00 C Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12999&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11583256 46513425 ZINC13673229 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23410 Cc1cc(ccc1N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O)N1CCOCC1 InChI=1S/C20H22ClN3O4S/c1-13-10-14(23-6-8-27-9-7-23)2-3-16(13)24-12-15(28-20(24)26)11-22-19(25)17-4-5-18(21)29-17/h2-5,10,15H,6-9,11-12H2,1H3,(H,22,25)/t15-/m0/s1 OYFFEZUIIXCYJD-HNNXBMFYSA-N 7632 BAY 59-7939 Analog 15::US8822458, 36 Coagulation factor X Homo sapiens 1260 8.3 25.00 C Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7632&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11575714 242052779 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23411 Clc1ccc(s1)C(=O)NC[C@@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m1/s1 KGFYHTZWPPHNLQ-CQSZACIVSA-N 13001 5-Chloro-N-({(5R)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide::5-chloro-N-{[(5R)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide::BAY 59-7939 Analog 16 Coagulation factor X Homo sapiens 2300 8.3 25.00 C Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13001&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11524901 46513427 ZINC01494180 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23412 Brc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C19H18BrN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1 RPXYGWOWNPRMRE-AWEZNQCLSA-N 7842 BAY 59-7939 Analog 17::US8822458, 46 Coagulation factor X Homo sapiens 0.4 8.3 25.00 C Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7842&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11569203 242052788 ZINC95393419 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23413 Cc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C20H21N3O5S/c1-13-2-7-17(29-13)19(25)21-10-16-11-23(20(26)28-16)15-5-3-14(4-6-15)22-8-9-27-12-18(22)24/h2-7,16H,8-12H2,1H3,(H,21,25)/t16-/m0/s1 YWRVKEHHSZEJNV-INIZCTEOSA-N 7841 BAY 59-7939 Analog 18::US8822458, 45::US9359341, Rivaroxaban Coagulation factor X Homo sapiens 4.2 Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7841&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11711363 242052787 ZINC95393419 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23414 Brc1ccc(o1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C19H18BrN3O6/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1 ITNMNPHEONYWAC-AWEZNQCLSA-N 13004 5-Bromo-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-furamide::5-bromo-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}furan-2-carboxamide::BAY 59-7939 Analog 19 Coagulation factor X Homo sapiens 26 Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13004&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10161902 46513430 ZINC03989201 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24568 CCOc1cc(cc(OCCc2ccc(Cl)cc2Cl)c1Br)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C28H30BrCl2N3O3/c1-2-36-25-15-21(16-26(27(25)29)37-14-9-20-3-4-22(30)17-24(20)31)28(35)33-18-19-7-12-34(13-8-19)23-5-10-32-11-6-23/h3-6,10-11,15-17,19H,2,7-9,12-14,18H2,1H3,(H,33,35) XOKXLVZTHDYGDO-UHFFFAOYSA-N 13660 3-Oxybenzamide 46::4-bromo-3-[2-(2,4-dichlorophenyl)ethoxy]-5-ethoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 86 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13660&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052336 46514052 ZINC14953531 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24569 COc1c(Br)cc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H28BrCl2N3O3/c1-35-26-23(28)14-20(15-25(26)36-13-8-19-2-3-21(29)16-24(19)30)27(34)32-17-18-6-11-33(12-7-18)22-4-9-31-10-5-22/h2-5,9-10,14-16,18H,6-8,11-13,17H2,1H3,(H,32,34) BDYFOSDTBNSZBW-UHFFFAOYSA-N 13661 3-Oxybenzamide 47::3-bromo-5-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 1053 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13661&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646475 46514053 ZINC14953536 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24570 COc1cc(cc(OCCc2ccc(Cl)cc2Cl)c1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H28Cl3N3O3/c1-35-24-14-20(15-25(26(24)30)36-13-8-19-2-3-21(28)16-23(19)29)27(34)32-17-18-6-11-33(12-7-18)22-4-9-31-10-5-22/h2-5,9-10,14-16,18H,6-8,11-13,17H2,1H3,(H,32,34) VPVZSERFJANUOF-UHFFFAOYSA-N 13662 3-Oxybenzamide 48::4-chloro-3-[2-(2,4-dichlorophenyl)ethoxy]-5-methoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 10 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13662&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9937410 46514054 ZINC14953541 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24571 COc1cc(cc(OCCc2ccc(Cl)cc2Cl)c1C)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C28H31Cl2N3O3/c1-19-26(35-2)15-22(16-27(19)36-14-9-21-3-4-23(29)17-25(21)30)28(34)32-18-20-7-12-33(13-8-20)24-5-10-31-11-6-24/h3-6,10-11,15-17,20H,7-9,12-14,18H2,1-2H3,(H,32,34) CRHWKPQYKCDTLK-UHFFFAOYSA-N 13663 3-Oxybenzamide 49::3-[2-(2,4-dichlorophenyl)ethoxy]-5-methoxy-4-methyl-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 13 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13663&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052323 46514055 ZINC13643396 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24572 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H29Cl2N3O3/c1-34-25-5-3-21(16-26(25)35-15-10-20-2-4-22(28)17-24(20)29)27(33)31-18-19-8-13-32(14-9-19)23-6-11-30-12-7-23/h2-7,11-12,16-17,19H,8-10,13-15,18H2,1H3,(H,31,33) UVSAHJWEJXWVGO-UHFFFAOYSA-N 13664 3-Oxybenzamide 50::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 18 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13664&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search I1H 2BMG 6420136 46514056 ZINC13643398 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24573 COc1ccc(cc1OCCc1ccc(Cl)cc1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H30ClN3O3/c1-33-25-7-4-22(18-26(25)34-17-12-20-2-5-23(28)6-3-20)27(32)30-19-21-10-15-31(16-11-21)24-8-13-29-14-9-24/h2-9,13-14,18,21H,10-12,15-17,19H2,1H3,(H,30,32) IHWQZDBTWMPDIP-UHFFFAOYSA-N 13665 3-Oxybenzamide 51::3-[2-(4-chlorophenyl)ethoxy]-4-methoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 41 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13665&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396258 46514057 ZINC13643401 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24574 COc1ccc(cc1OCCc1ccc(Cl)cn1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C26H29ClN4O3/c1-33-24-5-2-20(16-25(24)34-15-10-22-4-3-21(27)18-29-22)26(32)30-17-19-8-13-31(14-9-19)23-6-11-28-12-7-23/h2-7,11-12,16,18-19H,8-10,13-15,17H2,1H3,(H,30,32) FCFJQOMCLQWCHO-UHFFFAOYSA-N 13666 3-Oxybenzamide 52::3-[2-(5-chloropyridin-2-yl)ethoxy]-4-methoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 54 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13666&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052339 46514058 ZINC13643403 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24575 Clc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)c(Cl)c1 InChI=1S/C26H26Cl3N3O2/c27-21-3-1-19(24(29)16-21)9-14-34-25-15-20(2-4-23(25)28)26(33)31-17-18-7-12-32(13-8-18)22-5-10-30-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17H2,(H,31,33) OJUQZWAQJCEVIB-UHFFFAOYSA-N 13667 3-Oxybenzamide 53::4-chloro-3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 41 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13667&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052482 46514059 ZINC13643405 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24576 Clc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C26H27Cl2N3O2/c27-22-4-1-19(2-5-22)11-16-33-25-17-21(3-6-24(25)28)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18H2,(H,30,32) HGCZXLJPRIDMSF-UHFFFAOYSA-N 13668 3-Oxybenzamide 54::4-chloro-3-[2-(4-chlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 13 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13668&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052361 46509426 ZINC13643408 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24577 CC(=O)Oc1cc(cc(OCCc2ccc(Cl)cc2Cl)c1Br)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C28H28BrCl2N3O4/c1-18(35)38-26-15-21(14-25(27(26)29)37-13-8-20-2-3-22(30)16-24(20)31)28(36)33-17-19-6-11-34(12-7-19)23-4-9-32-10-5-23/h2-5,9-10,14-16,19H,6-8,11-13,17H2,1H3,(H,33,36) AFXSBHYPZXEQNT-UHFFFAOYSA-N 13669 2-bromo-3-[2-(2,4-dichlorophenyl)ethoxy]-5-({[1-(pyridin-4-yl)piperidin-4-yl]methyl}carbamoyl)phenyl acetate::3-Oxybenzamide 55 Coagulation factor X Homo sapiens 285 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13669&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646476 46514060 ZINC14953546 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24578 COc1cc(cc(OCCc2ccc(Cl)cc2)c1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H29Cl2N3O3/c1-34-24-16-21(17-25(26(24)29)35-15-10-19-2-4-22(28)5-3-19)27(33)31-18-20-8-13-32(14-9-20)23-6-11-30-12-7-23/h2-7,11-12,16-17,20H,8-10,13-15,18H2,1H3,(H,31,33) NDVCFINRSAXDMP-UHFFFAOYSA-N 13670 3-Oxybenzamide 56::4-chloro-3-[2-(4-chlorophenyl)ethoxy]-5-methoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 25 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13670&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052358 46514061 ZINC13643411 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24579 CCN(CC)C(=O)[C@H](CCCN=C(N)N)NC(=O)c1ccc(OC)c(OCCc2ccc(Cl)cc2Cl)c1 InChI=1S/C26H35Cl2N5O4/c1-4-33(5-2)25(35)21(7-6-13-31-26(29)30)32-24(34)18-9-11-22(36-3)23(15-18)37-14-12-17-8-10-19(27)16-20(17)28/h8-11,15-16,21H,4-7,12-14H2,1-3H3,(H,32,34)(H4,29,30,31)/t21-/m0/s1 OFZAUYABIXXPNV-NRFANRHFSA-N 13671 (2S)-5-carbamimidamido-2-({3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxyphenyl}formamido)-N,N-diethylpentanamide::3-Oxybenzamide 57 Coagulation factor X Homo sapiens 153 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13671&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11353394 46514062 ZINC14953551 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24580 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)C(N)=N InChI=1S/C23H28Cl2N4O3/c1-31-20-5-3-17(22(30)28-14-15-6-9-29(10-7-15)23(26)27)12-21(20)32-11-8-16-2-4-18(24)13-19(16)25/h2-5,12-13,15H,6-11,14H2,1H3,(H3,26,27)(H,28,30) DIBNTRMJSBDGEX-UHFFFAOYSA-N 13672 3-Oxybenzamide 58::N-[(1-carbamimidoylpiperidin-4-yl)methyl]-3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxybenzamide Coagulation factor X Homo sapiens 189 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13672&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10162765 46514063 ZINC00595115 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24581 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccnc(C)c1 InChI=1S/C28H31Cl2N3O3/c1-19-15-24(7-11-31-19)33-12-8-20(9-13-33)18-32-28(34)22-4-6-26(35-2)27(16-22)36-14-10-21-3-5-23(29)17-25(21)30/h3-7,11,15-17,20H,8-10,12-14,18H2,1-2H3,(H,32,34) ACFHSVNVQHUVJC-UHFFFAOYSA-N 13673 3-Oxybenzamide 59::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(2-methylpyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 57 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13673&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11466687 46514064 ZINC13643413 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24582 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncn1 InChI=1S/C26H28Cl2N4O3/c1-34-23-5-3-20(14-24(23)35-13-9-19-2-4-21(27)15-22(19)28)26(33)30-16-18-7-11-32(12-8-18)25-6-10-29-17-31-25/h2-6,10,14-15,17-18H,7-9,11-13,16H2,1H3,(H,30,33) YNZXWKUWGMCJGP-UHFFFAOYSA-N 13674 3-Oxybenzamide 60::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(pyrimidin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 110 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13674&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11156562 46514065 ZINC13643415 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24592 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccnc(Cl)n1 InChI=1S/C26H27Cl3N4O3/c1-35-22-5-3-19(14-23(22)36-13-9-18-2-4-20(27)15-21(18)28)25(34)31-16-17-7-11-33(12-8-17)24-6-10-30-26(29)32-24/h2-6,10,14-15,17H,7-9,11-13,16H2,1H3,(H,31,34) SYORKTQWURASHM-UHFFFAOYSA-N 13675 3-Oxybenzamide 61::N-{[1-(2-chloropyrimidin-4-yl)piperidin-4-yl]methyl}-3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxybenzamide Coagulation factor X Homo sapiens 264 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13675&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11249816 46514066 ZINC14953556 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24593 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)N1CCN(Cc2ccncc2)CC1 InChI=1S/C26H27Cl2N3O3/c1-33-24-5-3-21(16-25(24)34-15-8-20-2-4-22(27)17-23(20)28)26(32)31-13-11-30(12-14-31)18-19-6-9-29-10-7-19/h2-7,9-10,16-17H,8,11-15,18H2,1H3 SOJUZKVZNHWTCE-UHFFFAOYSA-N 13676 1-({3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxyphenyl}carbonyl)-4-(pyridin-4-ylmethyl)piperazine::3-Oxybenzamide 62 Coagulation factor X Homo sapiens 600 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13676&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10185372 46514067 ZINC13643417 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24594 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)C(C)C InChI=1S/C25H32Cl2N2O3/c1-17(2)29-11-8-18(9-12-29)16-28-25(30)20-5-7-23(31-3)24(14-20)32-13-10-19-4-6-21(26)15-22(19)27/h4-7,14-15,17-18H,8-13,16H2,1-3H3,(H,28,30) KDECAAPOPXMVQG-UHFFFAOYSA-N 13677 3-Oxybenzamide 63::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(propan-2-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 650 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13677&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11465752 46514068 ZINC13643419 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24595 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1cc[nH]c(=O)c1 InChI=1S/C27H29Cl2N3O4/c1-35-24-5-3-20(14-25(24)36-13-9-19-2-4-21(28)15-23(19)29)27(34)31-17-18-7-11-32(12-8-18)22-6-10-30-26(33)16-22/h2-6,10,14-16,18H,7-9,11-13,17H2,1H3,(H,30,33)(H,31,34) NMPHCWABBPGNJU-UHFFFAOYSA-N 13678 3-Oxybenzamide 64::3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(2-hydroxypyridin-4-yl)piperidin-4-yl]methyl}-4-methoxybenzamide Coagulation factor X Homo sapiens 950 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13678&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11214717 46514069 ZINC14953560 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24596 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(Cc2ccncc2)CC1 InChI=1S/C28H31Cl2N3O3/c1-35-26-5-3-23(16-27(26)36-15-10-22-2-4-24(29)17-25(22)30)28(34)32-18-20-8-13-33(14-9-20)19-21-6-11-31-12-7-21/h2-7,11-12,16-17,20H,8-10,13-15,18-19H2,1H3,(H,32,34) DFOLWHGZUDJOTI-UHFFFAOYSA-N 13679 3-Oxybenzamide 65::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(pyridin-4-ylmethyl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 970 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13679&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11398411 46514070 ZINC13643423 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24597 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CC(=NO1)c1ccncc1 InChI=1S/C25H23Cl2N3O4/c1-32-23-5-3-18(12-24(23)33-11-8-16-2-4-19(26)13-21(16)27)25(31)29-15-20-14-22(30-34-20)17-6-9-28-10-7-17/h2-7,9-10,12-13,20H,8,11,14-15H2,1H3,(H,29,31) FWCAYHIZLIGARK-UHFFFAOYSA-N 13680 3-Oxybenzamide 66::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[3-(pyridin-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]methyl}benzamide Coagulation factor X Homo sapiens 1128 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13680&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11432017 46514071 ZINC13643427 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24598 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)N1CCN(Cc2ccccn2)CC1 InChI=1S/C26H27Cl2N3O3/c1-33-24-8-6-20(16-25(24)34-15-9-19-5-7-21(27)17-23(19)28)26(32)31-13-11-30(12-14-31)18-22-4-2-3-10-29-22/h2-8,10,16-17H,9,11-15,18H2,1H3 AFNPURCEUOYCIM-UHFFFAOYSA-N 13681 1-({3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxyphenyl}carbonyl)-4-(pyridin-2-ylmethyl)piperazine::3-Oxybenzamide 67 Coagulation factor X Homo sapiens 1540 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13681&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11237358 46514072 ZINC13643430 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24599 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CC(=NO1)c1cc[n+]([O-])cc1 InChI=1S/C25H23Cl2N3O5/c1-33-23-5-3-18(12-24(23)34-11-8-16-2-4-19(26)13-21(16)27)25(31)28-15-20-14-22(29-35-20)17-6-9-30(32)10-7-17/h2-7,9-10,12-13,20H,8,11,14-15H2,1H3,(H,28,31) SWXCFUKUNYIBGW-UHFFFAOYSA-N 13682 3-Oxybenzamide 68::4-{5-[({3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxyphenyl}formamido)methyl]-4,5-dihydro-1,2-oxazol-3-yl}-1-oxidopyridin-1-ium Coagulation factor X Homo sapiens 960 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13682&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11341303 46514073 ZINC13643435 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24600 Cc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)N1CCN(Cc2cc[n+]([O-])cc2)CC1 InChI=1S/C26H27Cl2N3O3/c1-19-2-3-22(16-25(19)34-15-8-21-4-5-23(27)17-24(21)28)26(32)30-13-11-29(12-14-30)18-20-6-9-31(33)10-7-20/h2-7,9-10,16-17H,8,11-15,18H2,1H3 LNTOCGWTOIGILZ-UHFFFAOYSA-N 13683 3-Oxybenzamide 69::4-{[4-({3-[2-(2,4-dichlorophenyl)ethoxy]-4-methylphenyl}carbonyl)piperazin-1-yl]methyl}-1-oxidopyridin-1-ium Coagulation factor X Homo sapiens 407 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13683&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11488924 46514074 ZINC13643438 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24601 OCc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)N1CCN(Cc2cc[n+]([O-])cc2)CC1 InChI=1S/C26H27Cl2N3O4/c27-23-4-3-20(24(28)16-23)7-14-35-25-15-21(1-2-22(25)18-32)26(33)30-12-10-29(11-13-30)17-19-5-8-31(34)9-6-19/h1-6,8-9,15-16,32H,7,10-14,17-18H2 WRUXTLLPAKHXAH-UHFFFAOYSA-N 13684 3-Oxybenzamide 70::4-{[4-({3-[2-(2,4-dichlorophenyl)ethoxy]-4-(hydroxymethyl)phenyl}carbonyl)piperazin-1-yl]methyl}-1-oxidopyridin-1-ium Coagulation factor X Homo sapiens 6200 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13684&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11398207 46514075 ZINC13643440 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24602 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1cc(C)nc(N)n1 InChI=1S/C27H31Cl2N5O3/c1-17-13-25(33-27(30)32-17)34-10-7-18(8-11-34)16-31-26(35)20-4-6-23(36-2)24(14-20)37-12-9-19-3-5-21(28)15-22(19)29/h3-6,13-15,18H,7-12,16H2,1-2H3,(H,31,35)(H2,30,32,33) SEZYRXHDVWGWAJ-UHFFFAOYSA-N 13685 3-Oxybenzamide 71::N-{[1-(2-amino-6-methylpyrimidin-4-yl)piperidin-4-yl]methyl}-3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxybenzamide Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13685&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11478314 46514076 ZINC14953568 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24603 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccnc(SC)n1 InChI=1S/C27H30Cl2N4O3S/c1-35-23-6-4-20(15-24(23)36-14-10-19-3-5-21(28)16-22(19)29)26(34)31-17-18-8-12-33(13-9-18)25-7-11-30-27(32-25)37-2/h3-7,11,15-16,18H,8-10,12-14,17H2,1-2H3,(H,31,34) XXTIHUWHJJUUKW-UHFFFAOYSA-N 13686 3-Oxybenzamide 72::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-({1-[2-(methylsulfanyl)pyrimidin-4-yl]piperidin-4-yl}methyl)benzamide Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13686&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11398878 46514077 ZINC14953572 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24604 Cc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)C(N)=N InChI=1S/C23H28Cl2N4O2/c1-15-2-3-18(22(30)28-14-16-6-9-29(10-7-16)23(26)27)12-21(15)31-11-8-17-4-5-19(24)13-20(17)25/h2-5,12-13,16H,6-11,14H2,1H3,(H3,26,27)(H,28,30) ZIIZEJMMSHEFJI-UHFFFAOYSA-N 13687 3-Oxybenzamide 73::N-[(1-carbamimidoylpiperidin-4-yl)methyl]-3-[2-(2,4-dichlorophenyl)ethoxy]-4-methylbenzamide Coagulation factor X Homo sapiens 173 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13687&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11351714 46514078 ZINC00595117 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24605 Cc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)C(=N)NC(=O)OCc1ccccc1 InChI=1S/C31H34Cl2N4O4/c1-21-7-8-25(17-28(21)40-16-13-24-9-10-26(32)18-27(24)33)29(38)35-19-22-11-14-37(15-12-22)30(34)36-31(39)41-20-23-5-3-2-4-6-23/h2-10,17-18,22H,11-16,19-20H2,1H3,(H,35,38)(H2,34,36,39) HBPXQJPXONQAKC-UHFFFAOYSA-N 13688 3-Oxybenzamide 74::benzyl N-({4-[({3-[2-(2,4-dichlorophenyl)ethoxy]-4-methylphenyl}formamido)methyl]piperidin-1-yl}carboximidoyl)carbamate Coagulation factor X Homo sapiens 5077 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13688&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 15976119 46514079 ZINC14953578 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24606 CC(=N)N1CCC(CNC(=O)c2ccc(C)c(OCCc3ccc(Cl)cc3Cl)c2)CC1 InChI=1S/C24H29Cl2N3O2/c1-16-3-4-20(24(30)28-15-18-7-10-29(11-8-18)17(2)27)13-23(16)31-12-9-19-5-6-21(25)14-22(19)26/h3-6,13-14,18,27H,7-12,15H2,1-2H3,(H,28,30) GJLYGIJZQHYVIB-UHFFFAOYSA-N 13689 3-Oxybenzamide 75::3-[2-(2,4-dichlorophenyl)ethoxy]-N-[(1-ethanimidoylpiperidin-4-yl)methyl]-4-methylbenzamide Coagulation factor X Homo sapiens 140 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13689&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11236581 46514080 ZINC03976681 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24607 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccc(Cl)cc1 InChI=1S/C28H29Cl3N2O3/c1-35-26-9-3-21(16-27(26)36-15-12-20-2-4-23(30)17-25(20)31)28(34)32-18-19-10-13-33(14-11-19)24-7-5-22(29)6-8-24/h2-9,16-17,19H,10-15,18H2,1H3,(H,32,34) MSZUOWGLQCGNKZ-UHFFFAOYSA-N 13690 3-Oxybenzamide 76::N-{[1-(4-chlorophenyl)piperidin-4-yl]methyl}-3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxybenzamide Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13690&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11157065 46514081 ZINC14953583 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24608 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1cccc(c1)C#N InChI=1S/C29H29Cl2N3O3/c1-36-27-8-6-23(16-28(27)37-14-11-22-5-7-24(30)17-26(22)31)29(35)33-19-20-9-12-34(13-10-20)25-4-2-3-21(15-25)18-32/h2-8,15-17,20H,9-14,19H2,1H3,(H,33,35) LZXPPYJMLIRHNO-UHFFFAOYSA-N 13691 3-Oxybenzamide 77::N-{[1-(3-cyanophenyl)piperidin-4-yl]methyl}-3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxybenzamide Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13691&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11444061 46514082 ZINC14953587 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24609 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccc(cc1)S(C)(=O)=O InChI=1S/C29H32Cl2N2O5S/c1-37-27-10-4-22(17-28(27)38-16-13-21-3-5-23(30)18-26(21)31)29(34)32-19-20-11-14-33(15-12-20)24-6-8-25(9-7-24)39(2,35)36/h3-10,17-18,20H,11-16,19H2,1-2H3,(H,32,34) ZUSSCGJVSNYDJG-UHFFFAOYSA-N 13692 3-Oxybenzamide 78::3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(4-methanesulfonylphenyl)piperidin-4-yl]methyl}-4-methoxybenzamide Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13692&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11410761 46514083 ZINC14953592 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24610 COc1cc(nc(OC)n1)N1CCC(CNC(=O)c2ccc(OC)c(OCCc3ccc(Cl)cc3Cl)c2)CC1 InChI=1S/C28H32Cl2N4O5/c1-36-23-7-5-20(14-24(23)39-13-10-19-4-6-21(29)15-22(19)30)27(35)31-17-18-8-11-34(12-9-18)25-16-26(37-2)33-28(32-25)38-3/h4-7,14-16,18H,8-13,17H2,1-3H3,(H,31,35) HWYUMCWQKKYTNT-UHFFFAOYSA-N 13693 3-Oxybenzamide 79::3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(2,6-dimethoxypyrimidin-4-yl)piperidin-4-yl]methyl}-4-methoxybenzamide Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13693&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11444549 46514084 ZINC14953597 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24611 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1cc[n+]([O-])cc1 InChI=1S/C27H29Cl2N3O4/c1-35-25-5-3-21(16-26(25)36-15-10-20-2-4-22(28)17-24(20)29)27(33)30-18-19-6-11-31(12-7-19)23-8-13-32(34)14-9-23/h2-5,8-9,13-14,16-17,19H,6-7,10-12,15,18H2,1H3,(H,30,33) FBTFPMRXJWAEPC-UHFFFAOYSA-N 13694 3-Oxybenzamide 80 Coagulation factor X Homo sapiens 1484 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13694&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11443953 46514085 ZINC14953601 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24612 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)N1CCN(Cc2ccc(cc2)C#N)CC1 InChI=1S/C28H27Cl2N3O3/c1-35-26-9-7-23(16-27(26)36-15-10-22-6-8-24(29)17-25(22)30)28(34)33-13-11-32(12-14-33)19-21-4-2-20(18-31)3-5-21/h2-9,16-17H,10-15,19H2,1H3 VBPKKVPBRLGSCR-UHFFFAOYSA-N 13695 3-Oxybenzamide 81::4-{[4-({3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxyphenyl}carbonyl)piperazin-1-yl]methyl}benzonitrile Coagulation factor X Homo sapiens 1378 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13695&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11785772 46514086 ZINC13643442 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24613 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NC1CCN(CC1)c1cc[n+]([O-])cc1 InChI=1S/C26H27Cl2N3O4/c1-34-24-5-3-19(16-25(24)35-15-10-18-2-4-20(27)17-23(18)28)26(32)29-21-6-11-30(12-7-21)22-8-13-31(33)14-9-22/h2-5,8-9,13-14,16-17,21H,6-7,10-12,15H2,1H3,(H,29,32) PLIBHWCMLUVSLE-UHFFFAOYSA-N 13696 3-Oxybenzamide 82::4-[4-({3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxybenzene}amido)piperidin-1-yl]-1-oxidopyridin-1-ium Coagulation factor X Homo sapiens 1265 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13696&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11386766 46514087 ZINC13643444 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24614 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1cnccn1 InChI=1S/C26H28Cl2N4O3/c1-34-23-5-3-20(14-24(23)35-13-8-19-2-4-21(27)15-22(19)28)26(33)31-16-18-6-11-32(12-7-18)25-17-29-9-10-30-25/h2-5,9-10,14-15,17-18H,6-8,11-13,16H2,1H3,(H,31,33) XQQRSEDTRIFYKO-UHFFFAOYSA-N 13697 3-Oxybenzamide 83::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(pyrazin-2-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13697&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11364310 46514088 ZINC13643446 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24615 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1cncnc1 InChI=1S/C26H28Cl2N4O3/c1-34-24-5-3-20(12-25(24)35-11-8-19-2-4-21(27)13-23(19)28)26(33)31-14-18-6-9-32(10-7-18)22-15-29-17-30-16-22/h2-5,12-13,15-18H,6-11,14H2,1H3,(H,31,33) MHPITXQIMCKXAK-UHFFFAOYSA-N 13698 3-Oxybenzamide 84::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(pyrimidin-5-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13698&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11466448 46514089 ZINC13643449 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24616 COc1ccc(cn1)N1CCC(CNC(=O)c2ccc(OC)c(OCCc3ccc(Cl)cc3Cl)c2)CC1 InChI=1S/C28H31Cl2N3O4/c1-35-25-7-4-21(15-26(25)37-14-11-20-3-5-22(29)16-24(20)30)28(34)32-17-19-9-12-33(13-10-19)23-6-8-27(36-2)31-18-23/h3-8,15-16,18-19H,9-14,17H2,1-2H3,(H,32,34) OPEJJPYJOQCIBD-UHFFFAOYSA-N 13699 3-Oxybenzamide 85::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(6-methoxypyridin-3-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13699&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11168755 46514090 ZINC14953606 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24617 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)C1CCCCC1 InChI=1S/C28H36Cl2N2O3/c1-34-26-10-8-22(17-27(26)35-16-13-21-7-9-23(29)18-25(21)30)28(33)31-19-20-11-14-32(15-12-20)24-5-3-2-4-6-24/h7-10,17-18,20,24H,2-6,11-16,19H2,1H3,(H,31,33) LHUSVTGKUGHREB-UHFFFAOYSA-N 13700 3-Oxybenzamide 86::N-[(1-cyclohexylpiperidin-4-yl)methyl]-3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxybenzamide Coagulation factor X Homo sapiens 4327 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13700&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11226153 46514091 ZINC13643451 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24618 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC(=O)N(C)C)CC1 InChI=1S/C24H29Cl2N3O4/c1-27(2)23(30)16-28-9-11-29(12-10-28)24(31)18-5-7-21(32-3)22(14-18)33-13-8-17-4-6-19(25)15-20(17)26/h4-7,14-15H,8-13,16H2,1-3H3 UAMXEKYHGKDQPA-UHFFFAOYSA-N 13701 2-[4-({3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxyphenyl}carbonyl)piperazin-1-yl]-N,N-dimethylacetamide::3-Oxybenzamide 87 Coagulation factor X Homo sapiens 1412 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13701&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11329397 46514092 ZINC13643454 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24619 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccccc1 InChI=1S/C28H30Cl2N2O3/c1-34-26-10-8-22(17-27(26)35-16-13-21-7-9-23(29)18-25(21)30)28(33)31-19-20-11-14-32(15-12-20)24-5-3-2-4-6-24/h2-10,17-18,20H,11-16,19H2,1H3,(H,31,33) OFLOSNNYZAXCDO-UHFFFAOYSA-N 13702 3-Oxybenzamide 88::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-[(1-phenylpiperidin-4-yl)methyl]benzamide Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13702&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11260802 46514093 ZINC13643456 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24620 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)C1CCOCC1 InChI=1S/C27H34Cl2N2O4/c1-33-25-5-3-21(16-26(25)35-15-8-20-2-4-22(28)17-24(20)29)27(32)30-18-19-6-11-31(12-7-19)23-9-13-34-14-10-23/h2-5,16-17,19,23H,6-15,18H2,1H3,(H,30,32) KGSVUDYRNDYYMD-UHFFFAOYSA-N 13703 3-Oxybenzamide 89::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(oxan-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 1051 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13703&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11260937 46514094 ZINC13643458 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24621 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NC1CCN(CC1)C1CCCCC1 InChI=1S/C27H34Cl2N2O3/c1-33-25-10-8-20(17-26(25)34-16-13-19-7-9-21(28)18-24(19)29)27(32)30-22-11-14-31(15-12-22)23-5-3-2-4-6-23/h7-10,17-18,22-23H,2-6,11-16H2,1H3,(H,30,32) AMZLIHVZFBYWEX-UHFFFAOYSA-N 13704 3-Oxybenzamide 90::N-(1-cyclohexylpiperidin-4-yl)-3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxybenzamide Coagulation factor X Homo sapiens 4035 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13704&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11785424 46514095 ZINC13643461 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24622 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)C1CCNCC1 InChI=1S/C27H35Cl2N3O3/c1-34-25-5-3-21(16-26(25)35-15-10-20-2-4-22(28)17-24(20)29)27(33)31-18-19-8-13-32(14-9-19)23-6-11-30-12-7-23/h2-5,16-17,19,23,30H,6-15,18H2,1H3,(H,31,33) WVPKJUIQXLMIID-UHFFFAOYSA-N 13705 3-Oxybenzamide 91::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(piperidin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 5755 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13705&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11226168 46514096 ZINC13643465 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24623 COc1cc(cc(OCCc2ccc(Cl)cc2Cl)c1OC)C(=O)N1CCN(Cc2ccncc2)CC1 InChI=1S/C27H29Cl2N3O4/c1-34-24-15-21(27(33)32-12-10-31(11-13-32)18-19-5-8-30-9-6-19)16-25(26(24)35-2)36-14-7-20-3-4-22(28)17-23(20)29/h3-6,8-9,15-17H,7,10-14,18H2,1-2H3 FISLUEWNTGQBAP-UHFFFAOYSA-N 13706 1-({3-[2-(2,4-dichlorophenyl)ethoxy]-4,5-dimethoxyphenyl}carbonyl)-4-(pyridin-4-ylmethyl)piperazine::3-Oxybenzamide 92 Coagulation factor X Homo sapiens 167 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13706&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11785872 46514097 ZINC14953610 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24624 CCOc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)N1CCN(Cc2ccncc2)CC1 InChI=1S/C27H29Cl2N3O3/c1-2-34-25-6-4-22(17-26(25)35-16-9-21-3-5-23(28)18-24(21)29)27(33)32-14-12-31(13-15-32)19-20-7-10-30-11-8-20/h3-8,10-11,17-18H,2,9,12-16,19H2,1H3 IIIZKJYRBVJHEI-UHFFFAOYSA-N 13707 1-({3-[2-(2,4-dichlorophenyl)ethoxy]-4-ethoxyphenyl}carbonyl)-4-(pyridin-4-ylmethyl)piperazine::3-Oxybenzamide 93 Coagulation factor X Homo sapiens 306 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13707&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11752638 46514098 ZINC13643468 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24625 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)Nc1ccc(cc1)-c1ccccc1C#N InChI=1S/C29H22Cl2N2O3/c1-35-27-13-9-21(16-28(27)36-15-14-20-6-10-23(30)17-26(20)31)29(34)33-24-11-7-19(8-12-24)25-5-3-2-4-22(25)18-32/h2-13,16-17H,14-15H2,1H3,(H,33,34) NXFWNWTZOXXZMI-UHFFFAOYSA-N 13708 3-Oxybenzamide 94::N-[4-(2-cyanophenyl)phenyl]-3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxybenzamide Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13708&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11420982 46514099 ZINC13643471 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24626 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC1)c1ccncc1 InChI=1S/C25H25Cl2N3O3/c1-32-23-5-3-19(16-24(23)33-15-8-18-2-4-20(26)17-22(18)27)25(31)30-13-11-29(12-14-30)21-6-9-28-10-7-21/h2-7,9-10,16-17H,8,11-15H2,1H3 GWDRNDFJJHXBAV-UHFFFAOYSA-N 13709 1-({3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxyphenyl}carbonyl)-4-(pyridin-4-yl)piperazine::3-Oxybenzamide 95 Coagulation factor X Homo sapiens 5410 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13709&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11329232 46514100 ZINC13643473 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24627 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccccn1 InChI=1S/C27H29Cl2N3O3/c1-34-24-8-6-21(16-25(24)35-15-11-20-5-7-22(28)17-23(20)29)27(33)31-18-19-9-13-32(14-10-19)26-4-2-3-12-30-26/h2-8,12,16-17,19H,9-11,13-15,18H2,1H3,(H,31,33) XQUXMRXOJHGPCU-UHFFFAOYSA-N 13710 3-Oxybenzamide 96::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(pyridin-2-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 3040 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13710&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11443686 46514101 ZINC13643476 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24628 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)N1CCN(CC(=O)N2CCCC2)CC1 InChI=1S/C26H31Cl2N3O4/c1-34-23-7-5-20(16-24(23)35-15-8-19-4-6-21(27)17-22(19)28)26(33)31-13-11-29(12-14-31)18-25(32)30-9-2-3-10-30/h4-7,16-17H,2-3,8-15,18H2,1H3 IHTKSQOVIZSQLM-UHFFFAOYSA-N 13711 2-[4-({3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxyphenyl}carbonyl)piperazin-1-yl]-1-(pyrrolidin-1-yl)ethan-1-one::3-Oxybenzamide 97 Coagulation factor X Homo sapiens 2184 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13711&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11341378 46514102 ZINC13643478 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24629 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)N1CCN(Cc2ccc(F)cc2)CC1 InChI=1S/C27H27Cl2FN2O3/c1-34-25-9-5-21(16-26(25)35-15-10-20-4-6-22(28)17-24(20)29)27(33)32-13-11-31(12-14-32)18-19-2-7-23(30)8-3-19/h2-9,16-17H,10-15,18H2,1H3 HOLPNXWHHIMZAU-UHFFFAOYSA-N 13712 1-({3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxyphenyl}carbonyl)-4-[(4-fluorophenyl)methyl]piperazine::3-Oxybenzamide 98 Coagulation factor X Homo sapiens 3925 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13712&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11329788 46514103 ZINC13643482 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24630 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCCCN1CCCCC1 InChI=1S/C24H30Cl2N2O3/c1-30-22-9-7-19(24(29)27-11-5-14-28-12-3-2-4-13-28)16-23(22)31-15-10-18-6-8-20(25)17-21(18)26/h6-9,16-17H,2-5,10-15H2,1H3,(H,27,29) FDWXFMBRFUBYTF-UHFFFAOYSA-N 13713 3-Oxybenzamide 99::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-[3-(piperidin-1-yl)propyl]benzamide Coagulation factor X Homo sapiens 2221 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13713&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11213445 46514104 ZINC13643485 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24631 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCCN1CCCCC1 InChI=1S/C23H28Cl2N2O3/c1-29-21-8-6-18(23(28)26-10-13-27-11-3-2-4-12-27)15-22(21)30-14-9-17-5-7-19(24)16-20(17)25/h5-8,15-16H,2-4,9-14H2,1H3,(H,26,28) VKDYLTPIHXKULL-UHFFFAOYSA-N 13714 3-Oxybenzamide 100::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-[2-(piperidin-1-yl)ethyl]benzamide Coagulation factor X Homo sapiens 4219 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13714&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11408346 46514105 ZINC13643488 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24632 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCC(CN)CC1 InChI=1S/C24H30Cl2N2O3/c1-30-22-9-7-19(24(29)28-15-17-4-2-16(14-27)3-5-17)12-23(22)31-11-10-18-6-8-20(25)13-21(18)26/h6-9,12-13,16-17H,2-5,10-11,14-15,27H2,1H3,(H,28,29) DPKSMFRDSXBELI-UHFFFAOYSA-N 13715 3-Oxybenzamide 101::N-{[4-(aminomethyl)cyclohexyl]methyl}-3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxybenzamide Coagulation factor X Homo sapiens 9345 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13715&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11419907 46514106 ZINC13643491 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24633 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)C1CCCC1 InChI=1S/C27H34Cl2N2O3/c1-33-25-9-7-21(16-26(25)34-15-12-20-6-8-22(28)17-24(20)29)27(32)30-18-19-10-13-31(14-11-19)23-4-2-3-5-23/h6-9,16-17,19,23H,2-5,10-15,18H2,1H3,(H,30,32) KFNZXKNDQYZEAS-UHFFFAOYSA-N 13716 3-Oxybenzamide 102::N-[(1-cyclopentylpiperidin-4-yl)methyl]-3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxybenzamide Coagulation factor X Homo sapiens 6515 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13716&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11752478 46514107 ZINC13643495 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23415 Clc1ccc(cc1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C21H20ClN3O5/c22-15-3-1-14(2-4-15)20(27)23-11-18-12-25(21(28)30-18)17-7-5-16(6-8-17)24-9-10-29-13-19(24)26/h1-8,18H,9-13H2,(H,23,27)/t18-/m0/s1 OSNAJFJFYBDJTI-SFHVURJKSA-N 13005 4-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}benzamide::BAY 59-7939 Analog 20 Coagulation factor X Homo sapiens 20 Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13005&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9932394 46513431 ZINC03989200 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23416 Clc1cccc(c1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C21H20ClN3O5/c22-15-3-1-2-14(10-15)20(27)23-11-18-12-25(21(28)30-18)17-6-4-16(5-7-17)24-8-9-29-13-19(24)26/h1-7,10,18H,8-9,11-13H2,(H,23,27)/t18-/m0/s1 AHUTXLKOPODYFZ-SFHVURJKSA-N 13006 3-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)benzamide::3-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}benzamide::BAY 59-7939 Analog 21 Coagulation factor X Homo sapiens 1170 Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13006&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11517577 46513432 ZINC13673237 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23417 Clc1ccccc1C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C21H20ClN3O5/c22-18-4-2-1-3-17(18)20(27)23-11-16-12-25(21(28)30-16)15-7-5-14(6-8-15)24-9-10-29-13-19(24)26/h1-8,16H,9-13H2,(H,23,27)/t16-/m0/s1 XOTGRISGKWUOHU-INIZCTEOSA-N 13007 2-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)benzamide::2-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}benzamide::BAY 59-7939 Analog 22 Coagulation factor X Homo sapiens 2000 Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13007&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11546456 46513433 ZINC12355081 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23418 Nc1cc(sc1Cl)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C19H19ClN4O5S/c20-17-14(21)7-15(30-17)18(26)22-8-13-9-24(19(27)29-13)12-3-1-11(2-4-12)23-5-6-28-10-16(23)25/h1-4,7,13H,5-6,8-10,21H2,(H,22,26)/t13-/m0/s1 QERPGNOOHMKUJW-ZDUSSCGKSA-N 13008 4-Amino-5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide::4-amino-5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide::BAY 59-7939 Analog 23 Coagulation factor X Homo sapiens 8.5 Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13008&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11554212 46513434 ZINC13673239 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23419 Clc1ncc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C18H17ClN4O5S/c19-17-21-8-14(29-17)16(25)20-7-13-9-23(18(26)28-13)12-3-1-11(2-4-12)22-5-6-27-10-15(22)24/h1-4,8,13H,5-7,9-10H2,(H,20,25)/t13-/m0/s1 ZDLLSWMVGIODIZ-ZDUSSCGKSA-N 13009 2-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1,3-thiazole-5-carboxamide::2-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}-1,3-thiazole-5-carboxamide::BAY 59-7939 Analog 24 Coagulation factor X Homo sapiens 290 Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13009&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11618984 46513435 ZINC13673241 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23420 Clc1ccc(nc1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C20H19ClN4O5/c21-13-1-6-17(22-9-13)19(27)23-10-16-11-25(20(28)30-16)15-4-2-14(3-5-15)24-7-8-29-12-18(24)26/h1-6,9,16H,7-8,10-12H2,(H,23,27)/t16-/m0/s1 ZXSTZOOEFRAGJG-INIZCTEOSA-N 13010 5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)pyridine-2-carboxamide::5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}pyridine-2-carboxamide::BAY 59-7939 Analog 25 Coagulation factor X Homo sapiens 29 Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13010&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11718954 46513436 ZINC13673243 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23421 Clc1ccc(cn1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C20H19ClN4O5/c21-17-6-1-13(9-22-17)19(27)23-10-16-11-25(20(28)30-16)15-4-2-14(3-5-15)24-7-8-29-12-18(24)26/h1-6,9,16H,7-8,10-12H2,(H,23,27)/t16-/m0/s1 DFCKVMFGLWCSNQ-INIZCTEOSA-N 13011 6-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)nicotinamide::6-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}pyridine-3-carboxamide::BAY 59-7939 Analog 26 Coagulation factor X Homo sapiens 94 Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13011&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11539245 46513437 ZINC13673245 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23422 CN(C[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O)C(=O)c1ccc(Cl)s1 InChI=1S/C20H20ClN3O5S/c1-22(19(26)16-6-7-17(21)30-16)10-15-11-24(20(27)29-15)14-4-2-13(3-5-14)23-8-9-28-12-18(23)25/h2-7,15H,8-12H2,1H3/t15-/m0/s1 FAQYFCCIHWKTEZ-HNNXBMFYSA-N 13012 5-Chloro-N-methyl-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide::5-chloro-N-methyl-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide::BAY 59-7939 Analog 27 Coagulation factor X Homo sapiens 197 Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13012&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11518043 46513438 ZINC13673247 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 23423 Clc1ccc(s1)S(=O)(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O InChI=1S/C18H18ClN3O6S2/c19-15-5-6-17(29-15)30(25,26)20-9-14-10-22(18(24)28-14)13-3-1-12(2-4-13)21-7-8-27-11-16(21)23/h1-6,14,20H,7-11H2/t14-/m0/s1 CJUFNXYJEONNDC-AWEZNQCLSA-N 13013 5-Chloro-N-({(5R)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-sulfonamide::5-chloro-N-{[(5R)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-sulfonamide::BAY 59-7939 Analog 28 Coagulation factor X Homo sapiens 1200 Curated from the literature by BindingDB 10.1021/jm050101d 10.7270/Q2J38QR6 16161994 aid1796976 Roehrig, S; Straub, A; Pohlmann, J; Lampe, T; Pernerstorfer, J; Schlemmer, KH; Reinemer, P; Perzborn, E Bayer HealthCare AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13013&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11619782 46513439 ZINC13673249 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24634 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)C1CCCCCC1 InChI=1S/C29H38Cl2N2O3/c1-35-27-11-9-23(18-28(27)36-17-14-22-8-10-24(30)19-26(22)31)29(34)32-20-21-12-15-33(16-13-21)25-6-4-2-3-5-7-25/h8-11,18-19,21,25H,2-7,12-17,20H2,1H3,(H,32,34) DEEGMNGYQUUMOX-UHFFFAOYSA-N 13717 3-Oxybenzamide 103::N-[(1-cycloheptylpiperidin-4-yl)methyl]-3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxybenzamide Coagulation factor X Homo sapiens 6217 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13717&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11455413 46514108 ZINC13643500 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24635 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NC1CCN(CC1)C1CCOCC1 InChI=1S/C26H32Cl2N2O4/c1-32-24-5-3-19(16-25(24)34-15-8-18-2-4-20(27)17-23(18)28)26(31)29-21-6-11-30(12-7-21)22-9-13-33-14-10-22/h2-5,16-17,21-22H,6-15H2,1H3,(H,29,31) GQVLLJLAIFRJRG-UHFFFAOYSA-N 13718 3-Oxybenzamide 104::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-[1-(oxan-4-yl)piperidin-4-yl]benzamide Coagulation factor X Homo sapiens 2518 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13718&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11214337 46514109 ZINC13643504 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24636 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NC1CCN(CC(=O)N2CCCC2)CC1 InChI=1S/C27H33Cl2N3O4/c1-35-24-7-5-20(16-25(24)36-15-10-19-4-6-21(28)17-23(19)29)27(34)30-22-8-13-31(14-9-22)18-26(33)32-11-2-3-12-32/h4-7,16-17,22H,2-3,8-15,18H2,1H3,(H,30,34) DHDMHUQPQCPSEY-UHFFFAOYSA-N 13719 3-Oxybenzamide 105::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]piperidin-4-yl}benzamide Coagulation factor X Homo sapiens 2574 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13719&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11295553 46514110 ZINC14953615 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24637 Clc1ccc(CCOc2cccc(c2)C(=O)N2CCN(Cc3ccncc3)CC2)c(Cl)c1 InChI=1S/C25H25Cl2N3O2/c26-22-5-4-20(24(27)17-22)8-15-32-23-3-1-2-21(16-23)25(31)30-13-11-29(12-14-30)18-19-6-9-28-10-7-19/h1-7,9-10,16-17H,8,11-15,18H2 LMURKYCYIKGIMR-UHFFFAOYSA-N 13720 1-({3-[2-(2,4-dichlorophenyl)ethoxy]phenyl}carbonyl)-4-(pyridin-4-ylmethyl)piperazine::3-Oxybenzamide 106 Coagulation factor X Homo sapiens 2820 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13720&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11271356 46514111 ZINC13643507 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24638 [O-][N+](=O)c1ccc(OCCc2ccc(Cl)cc2Cl)cc1C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C26H26Cl2N4O4/c27-20-2-1-19(24(28)15-20)9-14-36-22-3-4-25(32(34)35)23(16-22)26(33)30-17-18-7-12-31(13-8-18)21-5-10-29-11-6-21/h1-6,10-11,15-16,18H,7-9,12-14,17H2,(H,30,33) RBTVVDDJDJONEL-UHFFFAOYSA-N 13721 3-Oxybenzamide 107::5-[2-(2,4-dichlorophenyl)ethoxy]-2-nitro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 4883 Curated from the literature by BindingDB 10.1021/jm049187l 10.7270/Q28C9THZ 15857135 aid1797071 Matter, H; Will, DW; Nazare, M; Schreuder, H; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13721&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11261069 46514112 ZINC14953622 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22349 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C25H27ClN4O2S/c1-16(2)29-11-9-18(10-12-29)27-25(31)21-13-17-5-3-4-6-20(17)30(21)15-19-14-22(32-28-19)23-7-8-24(26)33-23/h3-8,13-14,16,18H,9-12,15H2,1-2H3,(H,27,31) MMGXOGPDBICRQF-UHFFFAOYSA-N 12372 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 1::2-carboxyindole 22::2-carboxyindole-based inhibitor 10 Coagulation factor X Homo sapiens 3 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12372&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search IIA 2BOH 6540265 46512842 ZINC13646511 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22350 CC(C)N1CCC(CC1)NC(=O)c1cc2cc(F)ccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C25H26ClFN4O2S/c1-15(2)30-9-7-18(8-10-30)28-25(32)21-12-16-11-17(27)3-4-20(16)31(21)14-19-13-22(33-29-19)23-5-6-24(26)34-23/h3-6,11-13,15,18H,7-10,14H2,1-2H3,(H,28,32) UHRXNCPHRYVCHW-UHFFFAOYSA-N 12374 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-fluoro-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-5-fluoro-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 25 Coagulation factor X Homo sapiens 3 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12374&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11329534 46512843 ZINC13646515 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22351 CC(C)N1CCC(CC1)NC(=O)c1cc2cc(Cl)ccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C25H26Cl2N4O2S/c1-15(2)30-9-7-18(8-10-30)28-25(32)21-12-16-11-17(26)3-4-20(16)31(21)14-19-13-22(33-29-19)23-5-6-24(27)34-23/h3-6,11-13,15,18H,7-10,14H2,1-2H3,(H,28,32) DGAMIPORAILRPW-UHFFFAOYSA-N 12375 2-Carboxyindole Scaffold 26::5-Chloro-1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::5-chloro-1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 5 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12375&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11432325 46512844 ZINC13646517 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22352 CC(C)N1CCC(CC1)NC(=O)c1cc2cc(Br)ccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C25H26BrClN4O2S/c1-15(2)30-9-7-18(8-10-30)28-25(32)21-12-16-11-17(26)3-4-20(16)31(21)14-19-13-22(33-29-19)23-5-6-24(27)34-23/h3-6,11-13,15,18H,7-10,14H2,1-2H3,(H,28,32) GCPRDYGAADRGPV-UHFFFAOYSA-N 12376 2-Carboxyindole Scaffold 27::5-Bromo-1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::5-bromo-1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 9 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12376&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11432971 46512845 ZINC14949872 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22353 CC(C)N1CCC(CC1)NC(=O)c1cc2cc(OCc3ccccc3)ccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C32H33ClN4O3S/c1-21(2)36-14-12-24(13-15-36)34-32(38)28-17-23-16-26(39-20-22-6-4-3-5-7-22)8-9-27(23)37(28)19-25-18-29(40-35-25)30-10-11-31(33)41-30/h3-11,16-18,21,24H,12-15,19-20H2,1-2H3,(H,34,38) BFTIGQYPPHDMJL-UHFFFAOYSA-N 12377 2-Carboxyindole Scaffold 28::5-(benzyloxy)-1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::5-Benzyloxy-1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide Coagulation factor X Homo sapiens 835 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12377&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11433275 46512846 ZINC14949875 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22354 CC(C)N1CCC(CC1)NC(=O)c1cc2cc(C)ccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C26H29ClN4O2S/c1-16(2)30-10-8-19(9-11-30)28-26(32)22-13-18-12-17(3)4-5-21(18)31(22)15-20-14-23(33-29-20)24-6-7-25(27)34-24/h4-7,12-14,16,19H,8-11,15H2,1-3H3,(H,28,32) KKHCWZXQPKIWDG-UHFFFAOYSA-N 12378 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-methyl-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-5-methyl-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 29 Coagulation factor X Homo sapiens 9 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12378&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11248994 46512847 ZINC13646519 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22355 CC(C)N1CCC(CC1)NC(=O)c1cc2cc(ccc2n1Cc1cc(on1)-c1ccc(Cl)s1)C#N InChI=1S/C26H26ClN5O2S/c1-16(2)31-9-7-19(8-10-31)29-26(33)22-12-18-11-17(14-28)3-4-21(18)32(22)15-20-13-23(34-30-20)24-5-6-25(27)35-24/h3-6,11-13,16,19H,7-10,15H2,1-2H3,(H,29,33) NPNNJZJVTXOACX-UHFFFAOYSA-N 12379 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-cyano-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-5-cyano-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 30 Coagulation factor X Homo sapiens 2 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12379&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11283566 46512848 ZINC13646521 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22356 CC(C)N1CCC(CC1)NC(=O)c1cc2cc(ccc2n1Cc1cc(on1)-c1ccc(Cl)s1)S(C)(=O)=O InChI=1S/C26H29ClN4O4S2/c1-16(2)30-10-8-18(9-11-30)28-26(32)22-13-17-12-20(37(3,33)34)4-5-21(17)31(22)15-19-14-23(35-29-19)24-6-7-25(27)36-24/h4-7,12-14,16,18H,8-11,15H2,1-3H3,(H,28,32) ZEDLOMWFPPHULL-UHFFFAOYSA-N 12380 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-methanesulfonyl-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-5-methanesulfonyl-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 31 Coagulation factor X Homo sapiens 20 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12380&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801132 46512849 ZINC14949878 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22357 CC(C)N1CCC(CC1)NC(=O)c1cc2cc(ccc2n1Cc1cc(on1)-c1ccc(Cl)s1)[N+]([O-])=O InChI=1S/C25H26ClN5O4S/c1-15(2)29-9-7-17(8-10-29)27-25(32)21-12-16-11-19(31(33)34)3-4-20(16)30(21)14-18-13-22(35-28-18)23-5-6-24(26)36-23/h3-6,11-13,15,17H,7-10,14H2,1-2H3,(H,27,32) IGEMJMNVYQORGC-UHFFFAOYSA-N 12381 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-nitro-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-5-nitro-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 32 Coagulation factor X Homo sapiens 1 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12381&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10239497 46512850 ZINC14949881 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22358 CC(C)N1CCC(CC1)NC(=O)c1cc2c(Cl)cccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C25H26Cl2N4O2S/c1-15(2)30-10-8-16(9-11-30)28-25(32)21-13-18-19(26)4-3-5-20(18)31(21)14-17-12-22(33-29-17)23-6-7-24(27)34-23/h3-7,12-13,15-16H,8-11,14H2,1-2H3,(H,28,32) VZGXXNKOVRJPAJ-UHFFFAOYSA-N 12382 2-Carboxyindole Scaffold 33::4-Chloro-1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::4-chloro-1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 7 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12382&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11226109 46512851 ZINC13646523 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22359 CC(C)N1CCC(CC1)NC(=O)c1cc2ccc(Cl)cc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C25H26Cl2N4O2S/c1-15(2)30-9-7-18(8-10-30)28-25(32)21-11-16-3-4-17(26)12-20(16)31(21)14-19-13-22(33-29-19)23-5-6-24(27)34-23/h3-6,11-13,15,18H,7-10,14H2,1-2H3,(H,28,32) ZLQITWMSLIPBGT-UHFFFAOYSA-N 12383 2-Carboxyindole Scaffold 34::6-Chloro-1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::6-chloro-1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 7 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12383&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11179888 46512852 ZINC13646525 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22360 CC(C)N1CCC(CC1)NC(=O)c1cc2cccc(Cl)c2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C25H26Cl2N4O2S/c1-15(2)30-10-8-17(9-11-30)28-25(32)20-12-16-4-3-5-19(26)24(16)31(20)14-18-13-21(33-29-18)22-6-7-23(27)34-22/h3-7,12-13,15,17H,8-11,14H2,1-2H3,(H,28,32) NCAGDRYDCZWAGC-UHFFFAOYSA-N 12384 2-Carboxyindole Scaffold 35::7-Chloro-1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::7-chloro-1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 0.7 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12384&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11364346 46512853 ZINC13646527 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22361 CC(C)N1CCC(CC1)NC(=O)c1cc2c(C)cccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C26H29ClN4O2S/c1-16(2)30-11-9-18(10-12-30)28-26(32)22-14-20-17(3)5-4-6-21(20)31(22)15-19-13-23(33-29-19)24-7-8-25(27)34-24/h4-8,13-14,16,18H,9-12,15H2,1-3H3,(H,28,32) XVKKWLLVLUJXJU-UHFFFAOYSA-N 12385 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-4-methyl-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-4-methyl-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 36 Coagulation factor X Homo sapiens 3 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12385&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11785263 46512854 ZINC13646530 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22362 CC(C)N1CCC(CC1)NC(=O)c1cc2ccc(C)cc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C26H29ClN4O2S/c1-16(2)30-10-8-19(9-11-30)28-26(32)22-13-18-5-4-17(3)12-21(18)31(22)15-20-14-23(33-29-20)24-6-7-25(27)34-24/h4-7,12-14,16,19H,8-11,15H2,1-3H3,(H,28,32) ZZYWHGSUCVAUHI-UHFFFAOYSA-N 12386 1-[5-(5-Chlorothiophen-2-yl)isoxazol-3-ylmethyl]-6-methyl-1H-indole-2-carboxylic Acid (1-Isopropylpiperidin-4-yl)amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-6-methyl-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 13 Coagulation factor X Homo sapiens 18 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12386&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11479028 46512855 ZINC13646533 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22363 CC(C)N1CCC(CC1)NC(=O)c1cc2cccc(C)c2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C26H29ClN4O2S/c1-16(2)30-11-9-19(10-12-30)28-26(32)21-13-18-6-4-5-17(3)25(18)31(21)15-20-14-22(33-29-20)23-7-8-24(27)34-23/h4-8,13-14,16,19H,9-12,15H2,1-3H3,(H,28,32) IBXADCJSROAACD-UHFFFAOYSA-N 12387 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-7-methyl-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-7-methyl-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 37 Coagulation factor X Homo sapiens 0.25 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12387&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10289091 46512856 ZINC03816189 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22364 CC(C)N1CCC(CC1)NC(=O)c1cc2c(C)ccc(C)c2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C27H31ClN4O2S/c1-16(2)31-11-9-19(10-12-31)29-27(33)22-14-21-17(3)5-6-18(4)26(21)32(22)15-20-13-23(34-30-20)24-7-8-25(28)35-24/h5-8,13-14,16,19H,9-12,15H2,1-4H3,(H,29,33) UUWXQABINFEYRX-UHFFFAOYSA-N 12388 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-4,7-dimethyl-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-4,7-dimethyl-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 38 Coagulation factor X Homo sapiens 1 Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12388&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11249230 46512857 ZINC13646535 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22365 CC(C)N1CCC(CC1)NC(=O)c1cc2cccc([N+]([O-])=O)c2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C25H26ClN5O4S/c1-15(2)29-10-8-17(9-11-29)27-25(32)20-12-16-4-3-5-19(31(33)34)24(16)30(20)14-18-13-21(35-28-18)22-6-7-23(26)36-22/h3-7,12-13,15,17H,8-11,14H2,1-2H3,(H,27,32) FZIDKOXFABWJKQ-UHFFFAOYSA-N 12389 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-7-nitro-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-7-nitro-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 39 Coagulation factor X Homo sapiens 0.1 Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12389&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10128644 46512858 ZINC03915952 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22366 CC(C)N1CCC(CC1)NC(=O)c1c(F)c2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C25H26ClFN4O2S/c1-15(2)30-11-9-16(10-12-30)28-25(32)24-23(27)18-5-3-4-6-19(18)31(24)14-17-13-20(33-29-17)21-7-8-22(26)34-21/h3-8,13,15-16H,9-12,14H2,1-2H3,(H,28,32) KPIQURKZNMPNNM-UHFFFAOYSA-N 12390 1-[5-(5-Chlorothiophen-2-yl)isoxazol-3-ylmethyl]-3-fluoro-1H-indole-2-carboxylic Acid (1-Isopropylpiperidin-4-yl)amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-3-fluoro-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 22 Coagulation factor X Homo sapiens 2 Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12390&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10174464 46512859 ZINC13646537 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22367 CC(C)N1CCC(CC1)NC(=O)c1c(Cl)c2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C25H26Cl2N4O2S/c1-15(2)30-11-9-16(10-12-30)28-25(32)24-23(27)18-5-3-4-6-19(18)31(24)14-17-13-20(33-29-17)21-7-8-22(26)34-21/h3-8,13,15-16H,9-12,14H2,1-2H3,(H,28,32) SKYXWYPKUXHAPX-UHFFFAOYSA-N 12391 2-Carboxyindole Scaffold 23::3-chloro-1-{[5-(5-chlorothien-2-yl)isoxazol-3-yl]methyl}-N-(1-isopropylpiperidin-4-yl)-1H-indole-2-carboxamide::3-chloro-1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 2 Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12391&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10239377 46512860 ZINC13646540 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22368 CC(C)N1CCC(CC1)NC(=O)c1c(Br)c2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C25H26BrClN4O2S/c1-15(2)30-11-9-16(10-12-30)28-25(32)24-23(26)18-5-3-4-6-19(18)31(24)14-17-13-20(33-29-17)21-7-8-22(27)34-21/h3-8,13,15-16H,9-12,14H2,1-2H3,(H,28,32) SCWJRGNXCKCMBG-UHFFFAOYSA-N 12392 2-Carboxyindole Scaffold 24::3-Bromo-1-[5-(5-chlorothiophen-2-yl)isoxazol-3-yl-methyl]-1H-indole-2-carboxylic Acid (1-Isopropylpiperidin-4-yl)amide::3-bromo-1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 2 Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12392&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10218446 46512861 ZINC14949884 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22369 CC(C)N1CCC(CC1)NC(=O)c1c(C)c2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C26H29ClN4O2S/c1-16(2)30-12-10-18(11-13-30)28-26(32)25-17(3)20-6-4-5-7-21(20)31(25)15-19-14-22(33-29-19)23-8-9-24(27)34-23/h4-9,14,16,18H,10-13,15H2,1-3H3,(H,28,32) KZMKQWRSPBBHFH-UHFFFAOYSA-N 12393 1-[5-(5-Chlorothiophen-2-yl)isoxazol-3-ylmethyl]-3-methyl-1H-indole-2-carboxylic Acid (1-Isopropylpiperidin-4-yl)amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-3-methyl-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 17 Coagulation factor X Homo sapiens 3 Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12393&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11363985 46512862 ZINC13646543 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22370 CC(C)N1CCC(CC1)NC(=O)c1c(-c2ccccc2)c2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C31H31ClN4O2S/c1-20(2)35-16-14-22(15-17-35)33-31(37)30-29(21-8-4-3-5-9-21)24-10-6-7-11-25(24)36(30)19-23-18-26(38-34-23)27-12-13-28(32)39-27/h3-13,18,20,22H,14-17,19H2,1-2H3,(H,33,37) NBRCEBZBAGMRKS-UHFFFAOYSA-N 12394 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-3-phenyl-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-3-phenyl-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 40 Coagulation factor X Homo sapiens 55 Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12394&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11387388 46512863 ZINC14949887 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22371 CC(C)N1CCC(CC1)NC(=O)c1c(C#N)c2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C26H26ClN5O2S/c1-16(2)31-11-9-17(10-12-31)29-26(33)25-20(14-28)19-5-3-4-6-21(19)32(25)15-18-13-22(34-30-18)23-7-8-24(27)35-23/h3-8,13,16-17H,9-12,15H2,1-2H3,(H,29,33) YNGBTQWWOMFMNU-UHFFFAOYSA-N 12395 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-3-cyano-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-3-cyano-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 41 Coagulation factor X Homo sapiens 0.3 Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12395&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10128374 46512864 ZINC03816190 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22372 CC(C)N1CCC(CC1)NC(=O)c1c(C#N)c2cccc(C)c2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C27H28ClN5O2S/c1-16(2)32-11-9-18(10-12-32)30-27(34)26-21(14-29)20-6-4-5-17(3)25(20)33(26)15-19-13-22(35-31-19)23-7-8-24(28)36-23/h4-8,13,16,18H,9-12,15H2,1-3H3,(H,30,34) MCLVKEPZVPUETD-UHFFFAOYSA-N 12396 1-[5-(5-Chlorothiophen-2-yl)isoxazol-3-ylmethyl]-3-cyano-7-methyl-1H-indole-2- carboxylic Acid (1-Isopropylpiperidin-4-yl)amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-3-cyano-7-methyl-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 21 Coagulation factor X Homo sapiens 0.07 Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12396&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search IIB 2BQ6 6540266 46512865 ZINC03816191 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22373 CC(C)N1CCC(CC1)NC(=O)c1c(C#N)c2cc(ccc2n1Cc1cc(on1)-c1ccc(Cl)s1)S(C)(=O)=O InChI=1S/C27H28ClN5O4S2/c1-16(2)32-10-8-17(9-11-32)30-27(34)26-21(14-29)20-13-19(39(3,35)36)4-5-22(20)33(26)15-18-12-23(37-31-18)24-6-7-25(28)38-24/h4-7,12-13,16-17H,8-11,15H2,1-3H3,(H,30,34) WDVNUKZSXSEMJC-UHFFFAOYSA-N 12397 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-3-cyano-5-methanesulfonyl-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-3-cyano-5-methanesulfonyl-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 42 Coagulation factor X Homo sapiens 7 Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12397&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646071 46512866 ZINC14949890 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22374 COc1cccc(Cn2c(cc3ccccc23)C(=O)NC2CCN(CC2)C(C)C)c1 InChI=1S/C25H31N3O2/c1-18(2)27-13-11-21(12-14-27)26-25(29)24-16-20-8-4-5-10-23(20)28(24)17-19-7-6-9-22(15-19)30-3/h4-10,15-16,18,21H,11-14,17H2,1-3H3,(H,26,29) GIPCBGDQVGKMPO-UHFFFAOYSA-N 12398 1-(3-Methoxy-benzyl)-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::1-[(3-methoxyphenyl)methyl]-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 43::2-carboxyindole 12 Coagulation factor X Homo sapiens 89 Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12398&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search IID 2BQ7 6540267 46512867 DB07973 ZINC12355093 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22375 COc1cccc(Cn2c(C(=O)NC3CCN(CC3)C(C)C)c(C#N)c3cccc(C)c23)c1 InChI=1S/C27H32N4O2/c1-18(2)30-13-11-21(12-14-30)29-27(32)26-24(16-28)23-10-5-7-19(3)25(23)31(26)17-20-8-6-9-22(15-20)33-4/h5-10,15,18,21H,11-14,17H2,1-4H3,(H,29,32) ZQRWCINGUCSZGO-UHFFFAOYSA-N 12399 2-Carboxyindole Scaffold 44::3-Cyano-1-(3-methoxy-benzyl)-7-methyl-1H-indole-2-carboxylic acid (1-isopropylpiperidin-4-yl)-amide::3-cyano-1-[(3-methoxyphenyl)methyl]-7-methyl-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 406 Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12399&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11442160 46512868 ZINC13646546 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22376 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1CC(=O)Nc1ccc(Cl)cc1 InChI=1S/C25H29ClN4O2/c1-17(2)29-13-11-21(12-14-29)28-25(32)23-15-18-5-3-4-6-22(18)30(23)16-24(31)27-20-9-7-19(26)8-10-20/h3-10,15,17,21H,11-14,16H2,1-2H3,(H,27,31)(H,28,32) BDLMBQRBNPDCSS-UHFFFAOYSA-N 12400 1-[(4-Chloro-phenylcarbamoyl)-methyl]-1H-indole-2-carboxylic acid (1-isopropylpiperidin-4-yl)-amide::1-{[(4-chlorophenyl)carbamoyl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 45::2-carboxyindole 27 Coagulation factor X Homo sapiens 3 Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12400&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search IIE 2BQW 6540268 46512869 DB07974 ZINC13646547 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22377 CC(C)N1CCC(CC1)NC(=O)c1c(C#N)c2cccc(C)c2n1CC(=O)Nc1ccc(Cl)cc1 InChI=1S/C27H30ClN5O2/c1-17(2)32-13-11-21(12-14-32)31-27(35)26-23(15-29)22-6-4-5-18(3)25(22)33(26)16-24(34)30-20-9-7-19(28)8-10-20/h4-10,17,21H,11-14,16H2,1-3H3,(H,30,34)(H,31,35) VZDQBISOQDZNAK-UHFFFAOYSA-N 12401 1-[(4-Chloro-phenylcarbamoyl)-methyl]-3-cyano-7-methyl-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::1-{[(4-chlorophenyl)carbamoyl]methyl}-3-cyano-7-methyl-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 46 Coagulation factor X Homo sapiens 26 Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12401&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11294802 46512870 ZINC13646549 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 22378 Cc1cccc2n(Cc3cccc(c3)C(N)=N)c(cc12)C(=O)NCc1cc(Cl)cc(Cl)c1 InChI=1S/C25H22Cl2N4O/c1-15-4-2-7-22-21(15)12-23(25(32)30-13-17-9-19(26)11-20(27)10-17)31(22)14-16-5-3-6-18(8-16)24(28)29/h2-12H,13-14H2,1H3,(H3,28,29)(H,30,32) YAAKSJLUBVPBIM-UHFFFAOYSA-N 12402 1-[(3-carbamimidoylphenyl)methyl]-N-[(3,5-dichlorophenyl)methyl]-4-methyl-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 47::3-amidinobenzylindole carboxamide 41 Coagulation factor X Homo sapiens 25 Curated from the literature by BindingDB 10.1021/jm0490540 10.7270/Q21834RB 15999990 aid1796894 Nazare, M; Will, DW; Matter, H; Schreuder, H; Ritter, K; Urmann, M; Essrich, M; Bauer, A; Wagner, M; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12402&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search CMB 1LPZ 446982 46512871 ZINC02047778 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24761 NC(=N)c1ccc2nc([nH]c2c1)-c1cc(CC(O)=O)cc(c1O)-c1cccc(c1)[N+]([O-])=O InChI=1S/C22H17N5O5/c23-21(24)13-4-5-17-18(10-13)26-22(25-17)16-7-11(8-19(28)29)6-15(20(16)30)12-2-1-3-14(9-12)27(31)32/h1-7,9-10,30H,8H2,(H3,23,24)(H,25,26)(H,28,29) RQCZRRWVWILIAI-UHFFFAOYSA-N 13776 2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-hydroxy-5-(3-nitrophenyl)phenyl]acetic acid::CHEMBL207720::amidine-containing inhibitor 1 Coagulation factor X Homo sapiens 320 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.017 10.7270/Q2RF5S8X 16460932 aid1797087 Rai, R; Kolesnikov, A; Sprengeler, PA; Torkelson, S; Ton, T; Katz, BA; Yu, C; Hendrix, J; Shrader, WD; Stephens, R; Cabuslay, R; Sanford, E; Young, WB Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13776&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646499 46514162 CHEMBL207720 ZINC14953787 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24762 NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(CC(O)=O)cc(c1O)-c1cccc(c1)[N+]([O-])=O InChI=1S/C23H18N4O5/c24-23(25)14-4-5-19-15(9-14)11-20(26-19)18-7-12(8-21(28)29)6-17(22(18)30)13-2-1-3-16(10-13)27(31)32/h1-7,9-11,26,30H,8H2,(H3,24,25)(H,28,29) IDFDGLCIRPBHPZ-UHFFFAOYSA-N 13778 2-[3-(5-carbamimidoyl-1H-indol-2-yl)-4-hydroxy-5-(3-nitrophenyl)phenyl]acetic acid::CHEMBL76325::amidine-containing inhibitor 2 Coagulation factor X Homo sapiens 50 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.017 10.7270/Q2RF5S8X 16460932 aid1797087 Rai, R; Kolesnikov, A; Sprengeler, PA; Torkelson, S; Ton, T; Katz, BA; Yu, C; Hendrix, J; Shrader, WD; Stephens, R; Cabuslay, R; Sanford, E; Young, WB Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13778&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9910540 46514163 CHEMBL76325 ZINC01550218 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24763 OC(=O)Cc1cc(-c2nc3ccccc3[nH]2)c(O)c(c1)-c1cccc(c1)[N+]([O-])=O InChI=1S/C21H15N3O5/c25-19(26)10-12-8-15(13-4-3-5-14(11-13)24(28)29)20(27)16(9-12)21-22-17-6-1-2-7-18(17)23-21/h1-9,11,27H,10H2,(H,22,23)(H,25,26) CIPMQPTWGWCBLF-UHFFFAOYSA-N 13779 2-[3-(1H-1,3-benzodiazol-2-yl)-4-hydroxy-5-(3-nitrophenyl)phenyl]acetic acid::benzimidazole 3 Coagulation factor X Homo sapiens >150000 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.017 10.7270/Q2RF5S8X 16460932 aid1797087 Rai, R; Kolesnikov, A; Sprengeler, PA; Torkelson, S; Ton, T; Katz, BA; Yu, C; Hendrix, J; Shrader, WD; Stephens, R; Cabuslay, R; Sanford, E; Young, WB Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13779&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646500 46514164 ZINC14953799 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24764 Nc1ccc2[nH]c(nc2n1)-c1cc(CC(O)=O)cc(-c2cccc(c2)[N+]([O-])=O)c1O InChI=1S/C20H15N5O5/c21-16-5-4-15-20(23-16)24-19(22-15)14-7-10(8-17(26)27)6-13(18(14)28)11-2-1-3-12(9-11)25(29)30/h1-7,9,28H,8H2,(H,26,27)(H3,21,22,23,24) FIJGUBVGCGLGJQ-UHFFFAOYSA-N 13780 2-(3-{5-amino-1H-imidazo[4,5-b]pyridin-2-yl}-4-hydroxy-5-(3-nitrophenyl)phenyl)acetic acid::imidazopyridine analog 4 Coagulation factor X Homo sapiens >150000 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.017 10.7270/Q2RF5S8X 16460932 aid1797087 Rai, R; Kolesnikov, A; Sprengeler, PA; Torkelson, S; Ton, T; Katz, BA; Yu, C; Hendrix, J; Shrader, WD; Stephens, R; Cabuslay, R; Sanford, E; Young, WB Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13780&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646501 46514165 ZINC14953802 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24765 Nc1ccc2[nH]c(cc2n1)-c1cc(CC(O)=O)cc(c1O)-c1cccc(c1)[N+]([O-])=O InChI=1S/C21H16N4O5/c22-19-5-4-16-18(24-19)10-17(23-16)15-7-11(8-20(26)27)6-14(21(15)28)12-2-1-3-13(9-12)25(29)30/h1-7,9-10,23,28H,8H2,(H2,22,24)(H,26,27) BVBGZXXLVHYBKI-UHFFFAOYSA-N 13781 2-(3-{5-amino-1H-pyrrolo[3,2-b]pyridin-2-yl}-4-hydroxy-5-(3-nitrophenyl)phenyl)acetic acid::5-aminopyrrolo[3,2-b]pyridine 5 Coagulation factor X Homo sapiens 3500 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.01.017 10.7270/Q2RF5S8X 16460932 aid1797087 Rai, R; Kolesnikov, A; Sprengeler, PA; Torkelson, S; Ton, T; Katz, BA; Yu, C; Hendrix, J; Shrader, WD; Stephens, R; Cabuslay, R; Sanford, E; Young, WB Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13781&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search N1H 2F9B 6102815 46514166 DB08232 ZINC14953807 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24824 COC(=O)CN(Cc1cc[n+](C)cc1)C(=O)c1cc2ccccc2n1Cc1cccc(c1)C(N)=N InChI=1S/C27H28N5O3/c1-30-12-10-19(11-13-30)16-31(18-25(33)35-2)27(34)24-15-21-7-3-4-9-23(21)32(24)17-20-6-5-8-22(14-20)26(28)29/h3-15H,16-18H2,1-2H3,(H3,28,29)/q+1 PPPJOGJXGSRTQR-UHFFFAOYSA-N 13817 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-1H-indol-2-yl}-N-(2-methoxy-2-oxoethyl)formamido)methyl]-1-methylpyridin-1-ium::3-amidinobenzylindole carboxamide 1 Coagulation factor X Homo sapiens 170 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13817&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9894607 46514196 ZINC13474291 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24825 CCN(Cc1cc[n+](C)cc1)C(=O)c1cc2ccccc2n1Cc1cccc(c1)C(N)=N InChI=1S/C26H28N5O/c1-3-30(17-19-11-13-29(2)14-12-19)26(32)24-16-21-8-4-5-10-23(21)31(24)18-20-7-6-9-22(15-20)25(27)28/h4-16H,3,17-18H2,1-2H3,(H3,27,28)/q+1 PKSYFZKONVXRJY-UHFFFAOYSA-N 13818 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-1H-indol-2-yl}-N-ethylformamido)methyl]-1-methylpyridin-1-ium::3-amidinobenzylindole carboxamide 2 Coagulation factor X Homo sapiens 500 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13818&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9828698 46514197 ZINC13474292 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24826 NC(=N)c1cccc(Cn2c(C(=O)NCc3cc(Cl)cc(Cl)c3)c(Br)c3ccccc23)c1 InChI=1S/C24H19BrCl2N4O/c25-21-19-6-1-2-7-20(19)31(13-14-4-3-5-16(8-14)23(28)29)22(21)24(32)30-12-15-9-17(26)11-18(27)10-15/h1-11H,12-13H2,(H3,28,29)(H,30,32) FLKLQUOKVQOQHI-UHFFFAOYSA-N 13819 3-amidinobenzylindole carboxamide 3::3-bromo-1-[(3-carbamimidoylphenyl)methyl]-N-[(3,5-dichlorophenyl)methyl]-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 85 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13819&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10940389 46514198 ZINC03831855 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24827 Cc1cc(C)cc(CNC(=O)c2c(Br)c3ccccc3n2Cc2cccc(c2)C(N)=N)c1 InChI=1S/C26H25BrN4O/c1-16-10-17(2)12-19(11-16)14-30-26(32)24-23(27)21-8-3-4-9-22(21)31(24)15-18-6-5-7-20(13-18)25(28)29/h3-13H,14-15H2,1-2H3,(H3,28,29)(H,30,32) XRHPKJZWBNJDLW-UHFFFAOYSA-N 13820 3-amidinobenzylindole carboxamide 4::3-bromo-1-[(3-carbamimidoylphenyl)methyl]-N-[(3,5-dimethylphenyl)methyl]-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 13 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13820&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10983794 46514199 ZINC03831865 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24828 Cc1cccc2n(Cc3cccc(c3)C(N)=N)c(C(=O)NCc3cccc(c3)C(N)=N)c(Br)c12 InChI=1S/C26H25BrN6O/c1-15-5-2-10-20-21(15)22(27)23(33(20)14-17-7-4-9-19(12-17)25(30)31)26(34)32-13-16-6-3-8-18(11-16)24(28)29/h2-12H,13-14H2,1H3,(H3,28,29)(H3,30,31)(H,32,34) JBQWITKJQABBAY-UHFFFAOYSA-N 13821 3-amidinobenzylindole carboxamide 5::3-bromo-N,1-bis[(3-carbamimidoylphenyl)methyl]-4-methyl-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 50 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13821&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10864217 46514200 ZINC03831920 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24829 NC(=N)c1cccc(CNC(=O)c2c(Br)c3ccccc3n2Cc2cccc(c2)C(N)=N)c1 InChI=1S/C25H23BrN6O/c26-21-19-9-1-2-10-20(19)32(14-16-6-4-8-18(12-16)24(29)30)22(21)25(33)31-13-15-5-3-7-17(11-15)23(27)28/h1-12H,13-14H2,(H3,27,28)(H3,29,30)(H,31,33) NVOVMNVSNWBIRX-UHFFFAOYSA-N 13822 3-amidinobenzylindole carboxamide 6::3-bromo-N,1-bis[(3-carbamimidoylphenyl)methyl]-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 26 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13822&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11827247 46514201 ZINC03831892 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24830 Cc1c(C(=O)NCc2cc[n+](C)cc2)n(Cc2cccc(c2)C(N)=N)c2ccccc12 InChI=1S/C25H25N5O/c1-17-21-8-3-4-9-22(21)30(16-19-6-5-7-20(14-19)24(26)27)23(17)25(31)28-15-18-10-12-29(2)13-11-18/h3-14H,15-16H2,1-2H3,(H3-,26,27,28,31)/p+1 JOBDMJBFUZYBIW-UHFFFAOYSA-O 13823 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-3-methyl-1H-indol-2-yl}formamido)methyl]-1-methylpyridin-1-ium::3-amidinobenzylindole carboxamide 7 Coagulation factor X Homo sapiens 170 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13823&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11124238 46514202 ZINC13474293 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24831 NC(=N)c1cccc(Cn2c(C(=O)NCc3cccc4ccccc34)c(Cl)c3ccccc23)c1 InChI=1S/C28H23ClN4O/c29-25-23-13-3-4-14-24(23)33(17-18-7-5-10-20(15-18)27(30)31)26(25)28(34)32-16-21-11-6-9-19-8-1-2-12-22(19)21/h1-15H,16-17H2,(H3,30,31)(H,32,34) RAILUPZTMRJAKW-UHFFFAOYSA-N 13824 1-[(3-carbamimidoylphenyl)methyl]-3-chloro-N-(naphthalen-1-ylmethyl)-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 8 Coagulation factor X Homo sapiens 304 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13824&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11113397 46514203 ZINC03831897 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24832 NC(=N)c1cccc(CNC(=O)c2c(Cl)c3ccccc3n2Cc2cccc(c2)C(N)=N)c1 InChI=1S/C25H23ClN6O/c26-21-19-9-1-2-10-20(19)32(14-16-6-4-8-18(12-16)24(29)30)22(21)25(33)31-13-15-5-3-7-17(11-15)23(27)28/h1-12H,13-14H2,(H3,27,28)(H3,29,30)(H,31,33) ZBKZQMSDWQOTEJ-UHFFFAOYSA-N 13825 3-amidinobenzylindole carboxamide 9::N,1-bis[(3-carbamimidoylphenyl)methyl]-3-chloro-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 9 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13825&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10389462 46514204 ZINC01490442 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24833 C[N+](C)(C)c1ccc(CNC(=O)c2c(Cl)c3ccccc3n2Cc2cccc(c2)C(N)=N)cc1 InChI=1S/C27H28ClN5O/c1-33(2,3)21-13-11-18(12-14-21)16-31-27(34)25-24(28)22-9-4-5-10-23(22)32(25)17-19-7-6-8-20(15-19)26(29)30/h4-15H,16-17H2,1-3H3,(H3-,29,30,31,34)/p+1 POFFSHVKVGVVRB-UHFFFAOYSA-O 13826 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-3-chloro-1H-indol-2-yl}formamido)methyl]-N,N,N-trimethylanilinium::3-amidinobenzylindole carboxamide 10 Coagulation factor X Homo sapiens 40 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13826&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11966395 46514205 ZINC13474294 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24834 COC(=O)c1c(C(=O)NCc2cc[n+](C)cc2)n(Cc2cccc(c2)C(N)=N)c2ccccc12 InChI=1S/C26H25N5O3/c1-30-12-10-17(11-13-30)15-29-25(32)23-22(26(33)34-2)20-8-3-4-9-21(20)31(23)16-18-6-5-7-19(14-18)24(27)28/h3-14H,15-16H2,1-2H3,(H3-,27,28,29,32)/p+1 VNKLFYDRINLIJD-UHFFFAOYSA-O 13827 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-3-(methoxycarbonyl)-1H-indol-2-yl}formamido)methyl]-1-methylpyridin-1-ium::3-amidinobenzylindole carboxamide 11 Coagulation factor X Homo sapiens 350 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13827&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9959716 46514206 ZINC13474295 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24835 COc1cccc2n(Cc3cccc(c3)C(N)=N)c(cc12)C(=O)NC(C)c1cc[n+](C)cc1 InChI=1S/C26H27N5O2/c1-17(19-10-12-30(2)13-11-19)29-26(32)23-15-21-22(8-5-9-24(21)33-3)31(23)16-18-6-4-7-20(14-18)25(27)28/h4-15,17H,16H2,1-3H3,(H3-,27,28,29,32)/p+1 AZVBVPASVKJADG-UHFFFAOYSA-O 13828 2,2,2-trifluoroacetate; 4-[1-({1-[(3-carbamimidoylphenyl)methyl]-4-methoxy-1H-indol-2-yl}formamido)ethyl]-1-methylpyridin-1-ium::3-amidinobenzylindole carboxamide 12 Coagulation factor X Homo sapiens 160 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13828&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646525 46514207 ZINC14954004 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24836 C[n+]1ccc(CNC(=O)c2cc3ccccc3n2Cc2ccc(cc2)C(N)=N)cc1 InChI=1S/C24H23N5O/c1-28-12-10-17(11-13-28)15-27-24(30)22-14-20-4-2-3-5-21(20)29(22)16-18-6-8-19(9-7-18)23(25)26/h2-14H,15-16H2,1H3,(H3-,25,26,27,30)/p+1 JTXFYPDRKGTVII-UHFFFAOYSA-O 13829 2,2,2-trifluoroacetate; 4-[({1-[(4-carbamimidoylphenyl)methyl]-1H-indol-2-yl}formamido)methyl]-1-methylpyridin-1-ium::4-amidinobenzylindole carboxamide 13 Coagulation factor X Homo sapiens 600 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13829&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9827724 46514208 ZINC13474297 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24837 C[n+]1ccc(CNC(=O)c2cc3cc(F)ccc3n2Cc2cccc(c2)C(N)=N)cc1 InChI=1S/C24H22FN5O/c1-29-9-7-16(8-10-29)14-28-24(31)22-13-19-12-20(25)5-6-21(19)30(22)15-17-3-2-4-18(11-17)23(26)27/h2-13H,14-15H2,1H3,(H3-,26,27,28,31)/p+1 CTFRTIRVUYTLPU-UHFFFAOYSA-O 13830 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-5-fluoro-1H-indol-2-yl}formamido)methyl]-1-methylpyridin-1-ium::3-amidinobenzylindole carboxamide 14 Coagulation factor X Homo sapiens 360 7.8 25.00 C Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13830&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9914912 46514209 ZINC13474298 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24841 C[n+]1ccc(CNC(=O)c2cc3ccccc3n2Cc2cccc(c2)C(N)=N)cc1 InChI=1S/C24H23N5O/c1-28-11-9-17(10-12-28)15-27-24(30)22-14-19-6-2-3-8-21(19)29(22)16-18-5-4-7-20(13-18)23(25)26/h2-14H,15-16H2,1H3,(H3-,25,26,27,30)/p+1 MSFXCQBITWOFFJ-UHFFFAOYSA-O 13831 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-1H-indol-2-yl}formamido)methyl]-1-methylpyridin-1-ium::3-amidinobenzylindole carboxamide 15 Coagulation factor X Homo sapiens 150 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13831&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9958024 46514210 ZINC13474299 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24842 C[n+]1ccc(CNC(=O)c2cc3cc(N)ccc3n2Cc2cccc(c2)C(N)=N)cc1 InChI=1S/C24H24N6O/c1-29-9-7-16(8-10-29)14-28-24(31)22-13-19-12-20(25)5-6-21(19)30(22)15-17-3-2-4-18(11-17)23(26)27/h2-13H,14-15,25H2,1H3,(H3-,26,27,28,31)/p+1 GUOKCKDQHOLDBV-UHFFFAOYSA-O 13832 2,2,2-trifluoroacetate; 4-[({5-amino-1-[(3-carbamimidoylphenyl)methyl]-1H-indol-2-yl}formamido)methyl]-1-methylpyridin-1-ium::3-amidinobenzylindole carboxamide 16 Coagulation factor X Homo sapiens 100 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13832&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11734114 46514211 ZINC13474300 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24843 COc1cccc2n(Cc3cccc(c3)C(N)=N)c(cc12)C(=O)NCc1ccc(cc1)-c1cc[n+](C)cc1 InChI=1S/C31H29N5O2/c1-35-15-13-24(14-16-35)23-11-9-21(10-12-23)19-34-31(37)28-18-26-27(7-4-8-29(26)38-2)36(28)20-22-5-3-6-25(17-22)30(32)33/h3-18H,19-20H2,1-2H3,(H3-,32,33,34,37)/p+1 QOGWVVKYAKRDMT-UHFFFAOYSA-O 13833 2,2,2-trifluoroacetate; 4-{4-[({1-[(3-carbamimidoylphenyl)methyl]-4-methoxy-1H-indol-2-yl}formamido)methyl]phenyl}-1-methylpyridin-1-ium::3-amidinobenzylindole carboxamide 17 Coagulation factor X Homo sapiens 110 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13833&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646527 46514212 ZINC14954008 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24844 C[C@H](NC(=O)c1cc2ccccc2n1Cc1cccc(c1)C(N)=N)c1cc[n+](C)cc1 InChI=1S/C25H25N5O/c1-17(19-10-12-29(2)13-11-19)28-25(31)23-15-20-7-3-4-9-22(20)30(23)16-18-6-5-8-21(14-18)24(26)27/h3-15,17H,16H2,1-2H3,(H3-,26,27,28,31)/p+1/t17-/m0/s1 AKXZAAVWDZSLLA-KRWDZBQOSA-O 13834 2,2,2-trifluoroacetate; 4-[(1S)-1-({1-[(3-carbamimidoylphenyl)methyl]-1H-indol-2-yl}formamido)ethyl]-1-methylpyridin-1-ium::3-amidinobenzylindole carboxamide 18 Coagulation factor X Homo sapiens 92 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13834&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10875074 46514213 ZINC13474303 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24845 C[C@H](NC(=O)c1cc2cc(OCc3ccccc3)ccc2n1Cc1cccc(c1)C(N)=S)c1ccccc1 InChI=1S/C32H29N3O2S/c1-22(25-12-6-3-7-13-25)34-32(36)30-19-27-18-28(37-21-23-9-4-2-5-10-23)15-16-29(27)35(30)20-24-11-8-14-26(17-24)31(33)38/h2-19,22H,20-21H2,1H3,(H2,33,38)(H,34,36)/t22-/m0/s1 LRFUGRBYSOMJEJ-QFIPXVFZSA-N 13835 2,2,2-trifluoroacetic acid; 5-(benzyloxy)-1-[(3-carbamothioylphenyl)methyl]-N-[(1S)-1-phenylethyl]-1H-indole-2-carboxamide::3-thiocarbamoylbenzylindole carboxamide 19 Coagulation factor X Homo sapiens 4830 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13835&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11814240 46514214 ZINC03831925 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24846 C[C@H](NC(=O)c1cc2cc(OCc3ccccc3)ccc2n1Cc1cccc(c1)C(N)=N)c1ccccc1 InChI=1S/C32H30N4O2/c1-22(25-12-6-3-7-13-25)35-32(37)30-19-27-18-28(38-21-23-9-4-2-5-10-23)15-16-29(27)36(30)20-24-11-8-14-26(17-24)31(33)34/h2-19,22H,20-21H2,1H3,(H3,33,34)(H,35,37)/t22-/m0/s1 PXFITNRGNDJUHQ-QFIPXVFZSA-N 13836 2,2,2-trifluoroacetic acid; 5-(benzyloxy)-1-[(3-carbamimidoylphenyl)methyl]-N-[(1S)-1-phenylethyl]-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 20 Coagulation factor X Homo sapiens 3690 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13836&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9937758 46514215 ZINC03831911 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24847 Cc1cccc2n(Cc3cccc(c3)C(N)=N)c(cc12)C(=O)NCC1CCN(CC1)C(N)=N InChI=1S/C25H31N7O/c1-16-4-2-7-21-20(16)13-22(32(21)15-18-5-3-6-19(12-18)23(26)27)24(33)30-14-17-8-10-31(11-9-17)25(28)29/h2-7,12-13,17H,8-11,14-15H2,1H3,(H3,26,27)(H3,28,29)(H,30,33) ZBWHTMFRLICUBO-UHFFFAOYSA-N 13837 1-[(3-carbamimidoylphenyl)methyl]-N-[(1-carbamimidoylpiperidin-4-yl)methyl]-4-methyl-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 21 Coagulation factor X Homo sapiens 25 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13837&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11037642 46514216 ZINC03831861 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24848 C[n+]1ccc(CNC(=O)c2cc3c(O)cccc3n2Cc2cccc(c2)C(N)=N)c2ccccc12 InChI=1S/C28H25N5O2/c1-32-13-12-20(21-8-2-3-9-23(21)32)16-31-28(35)25-15-22-24(10-5-11-26(22)34)33(25)17-18-6-4-7-19(14-18)27(29)30/h2-15H,16-17H2,1H3,(H4-,29,30,31,34,35)/p+1 AMTBWKFXQOILDC-UHFFFAOYSA-O 13838 2,2,2-trifluoroacetate; 4-[({1-[(3-carbamimidoylphenyl)methyl]-4-hydroxy-1H-indol-2-yl}formamido)methyl]-1-methylquinolin-1-ium::3-amidinobenzylindole carboxamide 22 Coagulation factor X Homo sapiens 50 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13838&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10929909 46514217 ZINC13474304 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 24849 Cc1cccc2n(Cc3cccc(c3)C(N)=N)c(cc12)C(=O)NCc1cccc2ccccc12 InChI=1S/C29H26N4O/c1-19-7-4-14-26-25(19)16-27(33(26)18-20-8-5-11-22(15-20)28(30)31)29(34)32-17-23-12-6-10-21-9-2-3-13-24(21)23/h2-16H,17-18H2,1H3,(H3,30,31)(H,32,34) IDKGPACCMPKKQB-UHFFFAOYSA-N 13839 1-[(3-carbamimidoylphenyl)methyl]-4-methyl-N-(naphthalen-1-ylmethyl)-1H-indole-2-carboxamide::3-amidinobenzylindole carboxamide 23 Coagulation factor X Homo sapiens 96 Curated from the literature by BindingDB 10.1021/jm0111346 10.7270/Q27H1GTW 12061878 aid1797091 Matter, H; Defossa, E; Heinelt, U; Blohm, PM; Schneider, D; Muller, A; Herok, S; Schreuder, H; Liesum, A; Brachvogel, V; Lonze, P; Walser, A; Al-Obeidi, F; Wildgoose, P Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13839&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9803617 46514218 2163 ZINC03831848 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 27287 NC(=O)NCc1ccc(O)c(c1)-c1cccc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O InChI=1S/C22H20N6O3/c23-20(24)12-5-6-16-17(9-12)28-21(27-16)14-3-1-2-13(19(14)30)15-8-11(4-7-18(15)29)10-26-22(25)31/h1-9,29-30H,10H2,(H3,23,24)(H,27,28)(H3,25,26,31) AEOYTBFWYXDAMX-UHFFFAOYSA-N 14863 ({3-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-2-hydroxyphenyl]-4-hydroxyphenyl}methyl)urea::5-amidinobenzimidazole analog 1::CHEMBL378916 Coagulation factor X Homo sapiens 2700 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.03.049 10.7270/Q20P0X9Q 16621549 aid1797320 Riggs, JR; Hu, H; Kolesnikov, A; Leahy, EM; Wesson, KE; Shrader, WD; Vijaykumar, D; Wahl, TA; Tong, Z; Sprengeler, PA; Green, MJ; Yu, C; Katz, BA; Sanford, E; Nguyen, M; Cabuslay, R; Young, WB Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14863&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10479047 46515183 CHEMBL378916 ZINC14956587 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 27288 NC(=O)NCc1cccc(c1)-c1cccc(-c2cc3cnccc3[nH]2)c1O InChI=1S/C21H18N4O2/c22-21(27)24-11-13-3-1-4-14(9-13)16-5-2-6-17(20(16)26)19-10-15-12-23-8-7-18(15)25-19/h1-10,12,25-26H,11H2,(H3,22,24,27) SRPOHNDQBDHONJ-UHFFFAOYSA-N 14864 5-azaindole analog 2::{[3-(2-hydroxy-3-{1H-pyrrolo[3,2-c]pyridin-2-yl}phenyl)phenyl]methyl}urea Coagulation factor X Homo sapiens 125000 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.03.049 10.7270/Q20P0X9Q 16621549 aid1797320 Riggs, JR; Hu, H; Kolesnikov, A; Leahy, EM; Wesson, KE; Shrader, WD; Vijaykumar, D; Wahl, TA; Tong, Z; Sprengeler, PA; Green, MJ; Yu, C; Katz, BA; Sanford, E; Nguyen, M; Cabuslay, R; Young, WB Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14864&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 7NH 2FLR 15942655 46509449 DB07247 ZINC14956591 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 29544 NC(=N)c1ccc2nc(Cc3nc4ccc(cc4[nH]3)C(N)=N)[nH]c2c1 InChI=1S/C17H16N8/c18-16(19)8-1-3-10-12(5-8)24-14(22-10)7-15-23-11-4-2-9(17(20)21)6-13(11)25-15/h1-6H,7H2,(H3,18,19)(H3,20,21)(H,22,24)(H,23,25) QZKOOEFIMWKZPK-UHFFFAOYSA-N 16127 2,2 -methanediylbis(1H-benzimidazole-6-carboximidamide)::2-[(6-carbamimidoyl-1H-1,3-benzodiazol-2-yl)methyl]-1H-1,3-benzodiazole-6-carboximidamide::AIDS007118::BABIM::CHEMBL542712::CHEMBL99951 Coagulation factor X Homo sapiens 1 8.2 22.00 C Curated from the literature by BindingDB 10.1038/35422 10.7270/Q29P2ZW9 9468142 aid1797494 Katz, BA; Clark, JM; Finer-Moore, JS; Jenkins, TE; Johnson, CR; Ross, MJ; Luong, C; Moore, WR; Stroud, RM Arris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16127&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1C1S,1C1T,1C1V,1G9A,1G9B,1G9C,1G9D,1XUG,1XUK 2387 46516386 CHEMBL99951CHEMBL542712 ZINC03871731 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 29574 NC(=N)c1ccc2nc(Cc3nc4ccc(cc4[nH]3)C(N)=N)[nH]c2c1 InChI=1S/C17H16N8/c18-16(19)8-1-3-10-12(5-8)24-14(22-10)7-15-23-11-4-2-9(17(20)21)6-13(11)25-15/h1-6H,7H2,(H3,18,19)(H3,20,21)(H,22,24)(H,23,25) QZKOOEFIMWKZPK-UHFFFAOYSA-N 16127 2,2 -methanediylbis(1H-benzimidazole-6-carboximidamide)::2-[(6-carbamimidoyl-1H-1,3-benzodiazol-2-yl)methyl]-1H-1,3-benzodiazole-6-carboximidamide::AIDS007118::BABIM::CHEMBL542712::CHEMBL99951 Coagulation factor X Homo sapiens 10000 Curated from the literature by BindingDB 10.1038/35422 10.7270/Q29P2ZW9 9468142 aid1797494 Katz, BA; Clark, JM; Finer-Moore, JS; Jenkins, TE; Johnson, CR; Ross, MJ; Luong, C; Moore, WR; Stroud, RM Arris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16127&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1C1S,1C1T,1C1V,1G9A,1G9B,1G9C,1G9D,1XUG,1XUK 2387 46516386 CHEMBL99951CHEMBL542712 ZINC03871731 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30834 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(CC(F)(F)F)C2=NCCO2)c1Cl InChI=1S/C24H19Cl3F3N5O4S/c1-38-16-7-14(26)6-15(21(36)33-17-3-2-13(25)8-32-17)19(16)34-22(37)20-18(27)12(10-40-20)9-35(11-24(28,29)30)23-31-4-5-39-23/h2-3,6-8,10H,4-5,9,11H2,1H3,(H,34,37)(H,32,33,36) FZIOLFZTRAMFBA-UHFFFAOYSA-N 17113 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[4,5-dihydro-1,3-oxazol-2-yl(2,2,2-trifluoroethyl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 13c Coagulation factor X Homo sapiens 2.2 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17113&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732407 46517342 ZINC28655649 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30835 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C2=NCCO2)C(C)(C)C)c1Cl InChI=1S/C26H26Cl3N5O4S/c1-26(2,3)34(25-30-7-8-38-25)12-14-13-39-22(20(14)29)24(36)33-21-17(9-16(28)10-18(21)37-4)23(35)32-19-6-5-15(27)11-31-19/h5-6,9-11,13H,7-8,12H2,1-4H3,(H,33,36)(H,31,32,35) HCLMXXFGPOTPOI-UHFFFAOYSA-N 17114 4-{[tert-butyl(4,5-dihydro-1,3-oxazol-2-yl)amino]methyl}-3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 13d Coagulation factor X Homo sapiens 0.12 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17114&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732555 46517343 ZINC14963109 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30836 COCCN(Cc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl)C1=NCCO1 InChI=1S/C25H24Cl3N5O5S/c1-36-8-6-33(25-29-5-7-38-25)12-14-13-39-22(20(14)28)24(35)32-21-17(9-16(27)10-18(21)37-2)23(34)31-19-4-3-15(26)11-30-19/h3-4,9-11,13H,5-8,12H2,1-2H3,(H,32,35)(H,30,31,34) TVQSBEQUZFIHLK-UHFFFAOYSA-N 17115 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[4,5-dihydro-1,3-oxazol-2-yl(2-methoxyethyl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 13e Coagulation factor X Homo sapiens 0.26 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17115&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732557 46517344 ZINC14963114 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30837 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)C2=NCC(C)O2)c1Cl InChI=1S/C24H22Cl3N5O4S/c1-12-8-29-24(36-12)32(2)10-13-11-37-21(19(13)27)23(34)31-20-16(6-15(26)7-17(20)35-3)22(33)30-18-5-4-14(25)9-28-18/h4-7,9,11-12H,8,10H2,1-3H3,(H,31,34)(H,28,30,33) FYCOIHUIEIWMMT-UHFFFAOYSA-N 17116 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[methyl(5-methyl-4,5-dihydro-1,3-oxazol-2-yl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 13f Coagulation factor X Homo sapiens 0.12 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17116&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732559 46517345 ZINC14963125 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30838 CCN(Cc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl)C1=NC(C)CO1 InChI=1S/C25H24Cl3N5O4S/c1-4-33(25-30-13(2)11-37-25)10-14-12-38-22(20(14)28)24(35)32-21-17(7-16(27)8-18(21)36-3)23(34)31-19-6-5-15(26)9-29-19/h5-9,12-13H,4,10-11H2,1-3H3,(H,32,35)(H,29,31,34) HJYDFNHBDGEPFJ-UHFFFAOYSA-N 17117 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[ethyl(4-methyl-4,5-dihydro-1,3-oxazol-2-yl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 13g Coagulation factor X Homo sapiens 0.031 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17117&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732560 46517346 ZINC14963133 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30839 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)C2=NCCCO2)c1Cl InChI=1S/C24H22Cl3N5O4S/c1-32(24-28-6-3-7-36-24)11-13-12-37-21(19(13)27)23(34)31-20-16(8-15(26)9-17(20)35-2)22(33)30-18-5-4-14(25)10-29-18/h4-5,8-10,12H,3,6-7,11H2,1-2H3,(H,31,34)(H,29,30,33) PQEQQMLZYPTIEQ-UHFFFAOYSA-N 17118 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[5,6-dihydro-4H-1,3-oxazin-2-yl(methyl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 13h Coagulation factor X Homo sapiens 0.012 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17118&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732562 46517347 ZINC14963137 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30840 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)c2nc(O)co2)c1Cl InChI=1S/C23H18Cl3N5O5S/c1-31(23-29-17(32)9-36-23)8-11-10-37-20(18(11)26)22(34)30-19-14(5-13(25)6-15(19)35-2)21(33)28-16-4-3-12(24)7-27-16/h3-7,9-10,32H,8H2,1-2H3,(H,30,34)(H,27,28,33) NDEOVZYULHPZFD-UHFFFAOYSA-N 17119 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[methyl(4-oxo-4,5-dihydro-1,3-oxazol-2-yl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 13i Coagulation factor X Homo sapiens 0.026 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17119&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 54105093 46517348 ZINC14963141 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30841 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)C2=NCCS2)c1Cl InChI=1S/C23H20Cl3N5O3S2/c1-31(23-27-5-6-35-23)10-12-11-36-20(18(12)26)22(33)30-19-15(7-14(25)8-16(19)34-2)21(32)29-17-4-3-13(24)9-28-17/h3-4,7-9,11H,5-6,10H2,1-2H3,(H,30,33)(H,28,29,32) KYTPBHITFYEVPE-UHFFFAOYSA-N 17120 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[4,5-dihydro-1,3-thiazol-2-yl(methyl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 13j Coagulation factor X Homo sapiens 0.024 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17120&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732708 46517349 ZINC14963145 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30842 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)c2ncco2)c1Cl InChI=1S/C23H18Cl3N5O4S/c1-31(23-27-5-6-35-23)10-12-11-36-20(18(12)26)22(33)30-19-15(7-14(25)8-16(19)34-2)21(32)29-17-4-3-13(24)9-28-17/h3-9,11H,10H2,1-2H3,(H,30,33)(H,28,29,32) YVPSRJBNOKCMAX-UHFFFAOYSA-N 17121 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[methyl(1,3-oxazol-2-yl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 13k Coagulation factor X Homo sapiens 0.059 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17121&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 447194 46517350 ZINC02047708 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30843 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)C2=NCCC2)c1Cl InChI=1S/C24H22Cl3N5O3S/c1-32(19-4-3-7-28-19)11-13-12-36-22(20(13)27)24(34)31-21-16(8-15(26)9-17(21)35-2)23(33)30-18-6-5-14(25)10-29-18/h5-6,8-10,12H,3-4,7,11H2,1-2H3,(H,31,34)(H,29,30,33) ZCZOICVKCWBHJP-UHFFFAOYSA-N 17122 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[3,4-dihydro-2H-pyrrol-5-yl(methyl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 13l Coagulation factor X Homo sapiens 0.004 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17122&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732711 46517351 ZINC14963152 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30845 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN2CCOC2=N)c1Cl InChI=1S/C22H18Cl3N5O4S/c1-33-15-7-13(24)6-14(20(31)28-16-3-2-12(23)8-27-16)18(15)29-21(32)19-17(25)11(10-35-19)9-30-4-5-34-22(30)26/h2-3,6-8,10,26H,4-5,9H2,1H3,(H,29,32)(H,27,28,31) BZYDTWAKORLHJZ-UHFFFAOYSA-N 17123 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-[(2-imino-1,3-oxazolidin-3-yl)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 17a Coagulation factor X Homo sapiens 0.01 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17123&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732713 46517352 ZINC14963156 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30846 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN2CCSC2=N)c1Cl InChI=1S/C22H18Cl3N5O3S2/c1-33-15-7-13(24)6-14(20(31)28-16-3-2-12(23)8-27-16)18(15)29-21(32)19-17(25)11(10-35-19)9-30-4-5-34-22(30)26/h2-3,6-8,10,26H,4-5,9H2,1H3,(H,29,32)(H,27,28,31) IAADFSFBXKPDGE-UHFFFAOYSA-N 17124 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-[(2-imino-1,3-thiazolidin-3-yl)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 17b Coagulation factor X Homo sapiens 0.01 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17124&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732866 46517353 ZINC14963161 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30847 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN2CCNC2=N)c1Cl InChI=1S/C22H19Cl3N6O3S/c1-34-15-7-13(24)6-14(20(32)29-16-3-2-12(23)8-28-16)18(15)30-21(33)19-17(25)11(10-35-19)9-31-5-4-27-22(31)26/h2-3,6-8,10H,4-5,9H2,1H3,(H2,26,27)(H,30,33)(H,28,29,32) SGEWALGTCFYMKS-UHFFFAOYSA-N 17125 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-[(2-iminoimidazolidin-1-yl)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 17c Coagulation factor X Homo sapiens 0.01 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17125&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732868 46517354 ZINC14963166 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30848 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(Cn2cc(O)nc2N)c1Cl InChI=1S/C22H17Cl3N6O4S/c1-35-14-5-12(24)4-13(20(33)28-15-3-2-11(23)6-27-15)18(14)30-21(34)19-17(25)10(9-36-19)7-31-8-16(32)29-22(31)26/h2-6,8-9,32H,7H2,1H3,(H2,26,29)(H,30,34)(H,27,28,33) AOVYDJFOHVRAAH-UHFFFAOYSA-N 17126 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-[(2-imino-4-oxoimidazolidin-1-yl)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 17d Coagulation factor X Homo sapiens 0.034 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17126&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91895916 46517355 ZINC14963170 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30849 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN2CCN=C2SC)c1Cl InChI=1S/C23H20Cl3N5O3S2/c1-34-16-8-14(25)7-15(21(32)29-17-4-3-13(24)9-28-17)19(16)30-22(33)20-18(26)12(11-36-20)10-31-6-5-27-23(31)35-2/h3-4,7-9,11H,5-6,10H2,1-2H3,(H,30,33)(H,28,29,32) QPSUSLWQDBYHKB-UHFFFAOYSA-N 17127 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[2-(methylsulfanyl)-4,5-dihydro-1H-imidazol-1-yl]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 17e Coagulation factor X Homo sapiens 0.004 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17127&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732871 46517356 ZINC14963175 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30850 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN2CCN=C2C)c1Cl InChI=1S/C23H20Cl3N5O3S/c1-12-27-5-6-31(12)10-13-11-35-21(19(13)26)23(33)30-20-16(7-15(25)8-17(20)34-2)22(32)29-18-4-3-14(24)9-28-18/h3-4,7-9,11H,5-6,10H2,1-2H3,(H,30,33)(H,28,29,32) PRJDABIRCYRZFL-UHFFFAOYSA-N 17128 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-[(2-methyl-4,5-dihydro-1H-imidazol-1-yl)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 17f Coagulation factor X Homo sapiens 0.01 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17128&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732873 46517357 ZINC14963180 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30851 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN2CCN=C2)c1Cl InChI=1S/C22H18Cl3N5O3S/c1-33-16-7-14(24)6-15(21(31)28-17-3-2-13(23)8-27-17)19(16)29-22(32)20-18(25)12(10-34-20)9-30-5-4-26-11-30/h2-3,6-8,10-11H,4-5,9H2,1H3,(H,29,32)(H,27,28,31) KAYNNYHFHARCLZ-UHFFFAOYSA-N 17129 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-(4,5-dihydro-1H-imidazol-1-ylmethyl)thiophene-2-carboxamide::Thiophene-Anthranilamide, 17g Coagulation factor X Homo sapiens 0.004 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17129&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16733006 46517358 ZINC14963184 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30852 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)C(C)=N)c1Cl InChI=1S/C22H20Cl3N5O3S/c1-11(26)30(2)9-12-10-34-20(18(12)25)22(32)29-19-15(6-14(24)7-16(19)33-3)21(31)28-17-5-4-13(23)8-27-17/h4-8,10,26H,9H2,1-3H3,(H,29,32)(H,27,28,31) JKXFAJKKAORNCV-UHFFFAOYSA-N 17130 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-[(N-methylethanimidamido)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 17h Coagulation factor X Homo sapiens 0.01 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17130&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16733007 46517359 ZINC14963188 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30853 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)C(N)=N)c1Cl InChI=1S/C21H19Cl3N6O3S/c1-30(21(25)26)8-10-9-34-18(16(10)24)20(32)29-17-13(5-12(23)6-14(17)33-2)19(31)28-15-4-3-11(22)7-27-15/h3-7,9H,8H2,1-2H3,(H3,25,26)(H,29,32)(H,27,28,31) HMYQDPPZFYBXFB-UHFFFAOYSA-N 17131 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-(3-methylcarbamimidamidomethyl)thiophene-2-carboxamide::Thiophene-Anthranilamide, 17i Coagulation factor X Homo sapiens 0.01 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17131&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16733008 46517360 ZINC14963192 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30854 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(Cn2ccnc2)c1Cl InChI=1S/C22H16Cl3N5O3S/c1-33-16-7-14(24)6-15(21(31)28-17-3-2-13(23)8-27-17)19(16)29-22(32)20-18(25)12(10-34-20)9-30-5-4-26-11-30/h2-8,10-11H,9H2,1H3,(H,29,32)(H,27,28,31) QBKJMJCFJKCLRF-UHFFFAOYSA-N 17132 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-(1H-imidazol-1-ylmethyl)thiophene-2-carboxamide::Thiophene-Anthranilamide, 17j Coagulation factor X Homo sapiens 0.022 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17132&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16733010 46517361 ZINC14963196 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30855 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(Cn2ccnc2C)c1Cl InChI=1S/C23H18Cl3N5O3S/c1-12-27-5-6-31(12)10-13-11-35-21(19(13)26)23(33)30-20-16(7-15(25)8-17(20)34-2)22(32)29-18-4-3-14(24)9-28-18/h3-9,11H,10H2,1-2H3,(H,30,33)(H,28,29,32) BPIRVUNGRNOYQT-UHFFFAOYSA-N 17133 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-[(2-methyl-1H-imidazol-1-yl)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 17k Coagulation factor X Homo sapiens 0.01 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17133&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16733012 46517362 ZINC14963201 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30856 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(Cn2ccnc2N)c1Cl InChI=1S/C22H17Cl3N6O3S/c1-34-15-7-13(24)6-14(20(32)29-16-3-2-12(23)8-28-16)18(15)30-21(33)19-17(25)11(10-35-19)9-31-5-4-27-22(31)26/h2-8,10H,9H2,1H3,(H2,26,27)(H,30,33)(H,28,29,32) JBLTXNAFEYSKQX-UHFFFAOYSA-N 17134 4-[(2-amino-1H-imidazol-1-yl)methyl]-3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 17l Coagulation factor X Homo sapiens 0.006 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17134&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16733013 46517363 ZINC14963206 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30857 CNc1nccn1Cc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl InChI=1S/C23H19Cl3N6O3S/c1-27-23-28-5-6-32(23)10-12-11-36-20(18(12)26)22(34)31-19-15(7-14(25)8-16(19)35-2)21(33)30-17-4-3-13(24)9-29-17/h3-9,11H,10H2,1-2H3,(H,27,28)(H,31,34)(H,29,30,33) LLHSZBPXQIOQJJ-UHFFFAOYSA-N 17135 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[2-(methylamino)-1H-imidazol-1-yl]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 17m::ZK 813039::ZK813039 Coagulation factor X Homo sapiens 0.005 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17135&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 993 2P3T 18376720 46517364 ZINC14963211 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30858 CCNc1nccn1Cc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl InChI=1S/C24H21Cl3N6O3S/c1-3-28-24-29-6-7-33(24)11-13-12-37-21(19(13)27)23(35)32-20-16(8-15(26)9-17(20)36-2)22(34)31-18-5-4-14(25)10-30-18/h4-10,12H,3,11H2,1-2H3,(H,28,29)(H,32,35)(H,30,31,34) MMBDVBGJNUJKOG-UHFFFAOYSA-N 17136 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[2-(ethylamino)-1H-imidazol-1-yl]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 17n Coagulation factor X Homo sapiens 0.005 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17136&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376641 46517365 ZINC14963215 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30859 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(Cn2ccnc2NC(C)C)c1Cl InChI=1S/C25H23Cl3N6O3S/c1-13(2)31-25-29-6-7-34(25)11-14-12-38-22(20(14)28)24(36)33-21-17(8-16(27)9-18(21)37-3)23(35)32-19-5-4-15(26)10-30-19/h4-10,12-13H,11H2,1-3H3,(H,29,31)(H,33,36)(H,30,32,35) KXHOQPZAXTWOOG-UHFFFAOYSA-N 17137 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[2-(propan-2-ylamino)-1H-imidazol-1-yl]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 17o Coagulation factor X Homo sapiens 0.008 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17137&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647650 46517366 ZINC14963219 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30860 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)c2ncc[nH]2)c1Cl InChI=1S/C23H19Cl3N6O3S/c1-32(23-27-5-6-28-23)10-12-11-36-20(18(12)26)22(34)31-19-15(7-14(25)8-16(19)35-2)21(33)30-17-4-3-13(24)9-29-17/h3-9,11H,10H2,1-2H3,(H,27,28)(H,31,34)(H,29,30,33) IMKBPDVOEPDKGC-UHFFFAOYSA-N 17138 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[1H-imidazol-2-yl(methyl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 17p Coagulation factor X Homo sapiens 0.02 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17138&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16733150 46517367 ZINC14963223 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30804 Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(F)cc1 InChI=1S/C23H16ClFN2O2S/c1-13-6-11-18(17(12-13)22(28)26-15-9-7-14(25)8-10-15)27-23(29)21-20(24)16-4-2-3-5-19(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29) FBPXLHRHDPRVOH-UHFFFAOYSA-N 17084 3-chloro-N-{2-[(4-fluorophenyl)carbamoyl]-4-methylphenyl}-1-benzothiophene-2-carboxamide::anthranilamide compound 1 Coagulation factor X Homo sapiens 10 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17084&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 2796875 46517314 ZINC01033024 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30805 CN1CCN(Cc2csc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cc3)c2Cl)CC1 InChI=1S/C24H23Cl3N4O2S/c1-30-8-10-31(11-9-30)13-15-14-34-22(21(15)27)24(33)29-20-7-4-17(26)12-19(20)23(32)28-18-5-2-16(25)3-6-18/h2-7,12,14H,8-11,13H2,1H3,(H,28,32)(H,29,33) FIZKTFMGWNHPMZ-UHFFFAOYSA-N 17085 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-[(4-methylpiperazin-1-yl)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 2::thiophene-containing non-amidine inhibitor, 31 Coagulation factor X Homo sapiens 0.76 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17085&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search XLC 1MQ5 447193 46517315 ZINC21289563 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30806 CN1CCN(Cc2csc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cn3)c2Cl)CC1 InChI=1S/C23H22Cl3N5O2S/c1-30-6-8-31(9-7-30)12-14-13-34-21(20(14)26)23(33)28-18-4-2-15(24)10-17(18)22(32)29-19-5-3-16(25)11-27-19/h2-5,10-11,13H,6-9,12H2,1H3,(H,28,33)(H,27,29,32) FSCCPJPJIPZLON-UHFFFAOYSA-N 17086 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]phenyl}-4-[(4-methylpiperazin-1-yl)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 3a Coagulation factor X Homo sapiens 0.36 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17086&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16731823 46517316 ZINC23359229 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30807 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cc2)c1NC(=O)c1scc(CN2CCN(C)CC2)c1Cl InChI=1S/C25H25Cl3N4O3S/c1-31-7-9-32(10-8-31)13-15-14-36-23(21(15)28)25(34)30-22-19(11-17(27)12-20(22)35-2)24(33)29-18-5-3-16(26)4-6-18/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,29,33)(H,30,34) CFYDJHKIUFGPDT-UHFFFAOYSA-N 17087 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]-6-methoxyphenyl}-4-[(4-methylpiperazin-1-yl)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 3b Coagulation factor X Homo sapiens 0.43 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17087&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16731819 46517317 ZINC23359232 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30808 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN2CCN(C)CC2)c1Cl InChI=1S/C24H24Cl3N5O3S/c1-31-5-7-32(8-6-31)12-14-13-36-22(20(14)27)24(34)30-21-17(9-16(26)10-18(21)35-2)23(33)29-19-4-3-15(25)11-28-19/h3-4,9-11,13H,5-8,12H2,1-2H3,(H,30,34)(H,28,29,33) DBENURRVXMYTJS-UHFFFAOYSA-N 17088 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-[(4-methylpiperazin-1-yl)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 3c Coagulation factor X Homo sapiens 0.16 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17088&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16731821 46517318 ZINC23359235 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30809 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN)c1Cl InChI=1S/C19H15Cl3N4O3S/c1-29-13-5-11(21)4-12(18(27)25-14-3-2-10(20)7-24-14)16(13)26-19(28)17-15(22)9(6-23)8-30-17/h2-5,7-8H,6,23H2,1H3,(H,26,28)(H,24,25,27) ZQELKYLGCFHINW-UHFFFAOYSA-N 17089 4-(aminomethyl)-3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 10a Coagulation factor X Homo sapiens 1.0 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17089&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16731824 46517319 ZINC14963018 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30810 CNCc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl InChI=1S/C20H17Cl3N4O3S/c1-24-7-10-9-31-18(16(10)23)20(29)27-17-13(5-12(22)6-14(17)30-2)19(28)26-15-4-3-11(21)8-25-15/h3-6,8-9,24H,7H2,1-2H3,(H,27,29)(H,25,26,28) CYFNXPSIQONWKY-UHFFFAOYSA-N 17090 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-[(methylamino)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 10b::ZK 814048::ZK814048 Coagulation factor X Homo sapiens 0.21 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17090&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16731825 46517320 ZINC14963023 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30811 CCNCc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl InChI=1S/C21H19Cl3N4O3S/c1-3-25-8-11-10-32-19(17(11)24)21(30)28-18-14(6-13(23)7-15(18)31-2)20(29)27-16-5-4-12(22)9-26-16/h4-7,9-10,25H,3,8H2,1-2H3,(H,28,30)(H,26,27,29) WHDKIKHSLJFJEZ-UHFFFAOYSA-N 17091 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-[(ethylamino)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 10c Coagulation factor X Homo sapiens 0.4 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17091&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16731827 46517321 ZINC14963027 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30812 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CNC(C)C)c1Cl InChI=1S/C22H21Cl3N4O3S/c1-11(2)26-8-12-10-33-20(18(12)25)22(31)29-19-15(6-14(24)7-16(19)32-3)21(30)28-17-5-4-13(23)9-27-17/h4-7,9-11,26H,8H2,1-3H3,(H,29,31)(H,27,28,30) QOQVKFCBGUXLRM-UHFFFAOYSA-N 17092 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-[(propan-2-ylamino)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 10d Coagulation factor X Homo sapiens 1.4 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17092&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16731975 46517322 ZINC14963031 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30813 CCN(C)Cc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl InChI=1S/C22H21Cl3N4O3S/c1-4-29(2)10-12-11-33-20(18(12)25)22(31)28-19-15(7-14(24)8-16(19)32-3)21(30)27-17-6-5-13(23)9-26-17/h5-9,11H,4,10H2,1-3H3,(H,28,31)(H,26,27,30) ZORVPYUEFANYON-UHFFFAOYSA-N 17093 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[ethyl(methyl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 10e Coagulation factor X Homo sapiens 0.22 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17093&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16731976 46517323 ZINC14963034 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30814 CCN(CC)Cc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl InChI=1S/C23H23Cl3N4O3S/c1-4-30(5-2)11-13-12-34-21(19(13)26)23(32)29-20-16(8-15(25)9-17(20)33-3)22(31)28-18-7-6-14(24)10-27-18/h6-10,12H,4-5,11H2,1-3H3,(H,29,32)(H,27,28,31) LIHSLAWJIRIYRU-UHFFFAOYSA-N 17094 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-[(diethylamino)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 10f Coagulation factor X Homo sapiens 0.32 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17094&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9893544 46517324 ZINC14963038 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30815 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN2CCOCC2)c1Cl InChI=1S/C23H21Cl3N4O4S/c1-33-17-9-15(25)8-16(22(31)28-18-3-2-14(24)10-27-18)20(17)29-23(32)21-19(26)13(12-35-21)11-30-4-6-34-7-5-30/h2-3,8-10,12H,4-7,11H2,1H3,(H,29,32)(H,27,28,31) ZAEDZKGOISXFST-UHFFFAOYSA-N 17095 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-(morpholin-4-ylmethyl)thiophene-2-carboxamide::Thiophene-Anthranilamide, 10g Coagulation factor X Homo sapiens 1.4 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17095&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16731977 46517325 ZINC14963042 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30816 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN2CCCC2)c1Cl InChI=1S/C23H21Cl3N4O3S/c1-33-17-9-15(25)8-16(22(31)28-18-5-4-14(24)10-27-18)20(17)29-23(32)21-19(26)13(12-34-21)11-30-6-2-3-7-30/h4-5,8-10,12H,2-3,6-7,11H2,1H3,(H,29,32)(H,27,28,31) DGAZPLXRUCDHFC-UHFFFAOYSA-N 17096 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-(pyrrolidin-1-ylmethyl)thiophene-2-carboxamide::Thiophene-Anthranilamide, 10h Coagulation factor X Homo sapiens 0.52 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17096&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16731978 46517326 ZINC14963046 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30817 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN2CCC(O)CC2)c1Cl InChI=1S/C24H23Cl3N4O4S/c1-35-18-9-15(26)8-17(23(33)29-19-3-2-14(25)10-28-19)21(18)30-24(34)22-20(27)13(12-36-22)11-31-6-4-16(32)5-7-31/h2-3,8-10,12,16,32H,4-7,11H2,1H3,(H,30,34)(H,28,29,33) SEEPETPHVJFUOK-UHFFFAOYSA-N 17097 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-[(4-hydroxypiperidin-1-yl)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 10i Coagulation factor X Homo sapiens 2.2 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17097&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16731979 46517327 ZINC14963050 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30818 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)CCO)c1Cl InChI=1S/C22H21Cl3N4O4S/c1-29(5-6-30)10-12-11-34-20(18(12)25)22(32)28-19-15(7-14(24)8-16(19)33-2)21(31)27-17-4-3-13(23)9-26-17/h3-4,7-9,11,30H,5-6,10H2,1-2H3,(H,28,32)(H,26,27,31) WRWKTYIUPHVUDP-UHFFFAOYSA-N 17098 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[(2-hydroxyethyl)(methyl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 10j Coagulation factor X Homo sapiens 0.24 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17098&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16731980 46517328 ZINC14963054 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30819 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)CCCO)c1Cl InChI=1S/C23H23Cl3N4O4S/c1-30(6-3-7-31)11-13-12-35-21(19(13)26)23(33)29-20-16(8-15(25)9-17(20)34-2)22(32)28-18-5-4-14(24)10-27-18/h4-5,8-10,12,31H,3,6-7,11H2,1-2H3,(H,29,33)(H,27,28,32) JEQVXUZFFUSIEJ-UHFFFAOYSA-N 17099 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[(3-hydroxypropyl)(methyl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 10k Coagulation factor X Homo sapiens 0.18 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17099&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732121 46517329 ZINC14963058 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30820 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)CC(C)O)c1Cl InChI=1S/C23H23Cl3N4O4S/c1-12(31)9-30(2)10-13-11-35-21(19(13)26)23(33)29-20-16(6-15(25)7-17(20)34-3)22(32)28-18-5-4-14(24)8-27-18/h4-8,11-12,31H,9-10H2,1-3H3,(H,29,33)(H,27,28,32) LAIGHZMYXBMUOH-UHFFFAOYSA-N 17100 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[(2-hydroxypropyl)(methyl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 10l Coagulation factor X Homo sapiens 0.4 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17100&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732123 46517330 ZINC14963066 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30821 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)CC(C)(C)O)c1Cl InChI=1S/C24H25Cl3N4O4S/c1-24(2,34)12-31(3)10-13-11-36-21(19(13)27)23(33)30-20-16(7-15(26)8-17(20)35-4)22(32)29-18-6-5-14(25)9-28-18/h5-9,11,34H,10,12H2,1-4H3,(H,30,33)(H,28,29,32) FDWVHQKXWFKPKP-UHFFFAOYSA-N 17101 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[(2-hydroxy-2-methylpropyl)(methyl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 10m Coagulation factor X Homo sapiens 0.71 7.5 22.00 C Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17101&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732125 46517331 ZINC14963070 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30823 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)CC(O)CO)c1Cl InChI=1S/C23H23Cl3N4O5S/c1-30(9-15(32)10-31)8-12-11-36-21(19(12)26)23(34)29-20-16(5-14(25)6-17(20)35-2)22(33)28-18-4-3-13(24)7-27-18/h3-7,11,15,31-32H,8-10H2,1-2H3,(H,29,34)(H,27,28,33) UNCBIXCMUDNMIA-UHFFFAOYSA-N 17102 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[(2,3-dihydroxypropyl)(methyl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 10n Coagulation factor X Homo sapiens 0.26 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17102&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732126 46517332 ZINC14963078 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30824 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)CCCN(C)C)c1Cl InChI=1S/C25H28Cl3N5O3S/c1-32(2)8-5-9-33(3)13-15-14-37-23(21(15)28)25(35)31-22-18(10-17(27)11-19(22)36-4)24(34)30-20-7-6-16(26)12-29-20/h6-7,10-12,14H,5,8-9,13H2,1-4H3,(H,31,35)(H,29,30,34) GDSMPWPQGWPJIP-UHFFFAOYSA-N 17103 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-({[3-(dimethylamino)propyl](methyl)amino}methyl)thiophene-2-carboxamide::Thiophene-Anthranilamide, 10o Coagulation factor X Homo sapiens 0.024 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17103&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732127 46517333 ZINC14963082 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30825 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)CCN2CCCC2)c1Cl InChI=1S/C26H28Cl3N5O3S/c1-33(9-10-34-7-3-4-8-34)14-16-15-38-24(22(16)29)26(36)32-23-19(11-18(28)12-20(23)37-2)25(35)31-21-6-5-17(27)13-30-21/h5-6,11-13,15H,3-4,7-10,14H2,1-2H3,(H,32,36)(H,30,31,35) JNLUIKFYFVSZMB-UHFFFAOYSA-N 17104 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-({methyl[2-(pyrrolidin-1-yl)ethyl]amino}methyl)thiophene-2-carboxamide::Thiophene-Anthranilamide, 10p Coagulation factor X Homo sapiens 0.019 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17104&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732128 46517334 ZINC23359241 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30826 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)S(C)(=O)=O)c1Cl InChI=1S/C21H19Cl3N4O5S2/c1-28(35(3,31)32)9-11-10-34-19(17(11)24)21(30)27-18-14(6-13(23)7-15(18)33-2)20(29)26-16-5-4-12(22)8-25-16/h4-8,10H,9H2,1-3H3,(H,27,30)(H,25,26,29) LQMCYMIYCBGJPH-UHFFFAOYSA-N 17105 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[methane(methyl)sulfonamido]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 12a Coagulation factor X Homo sapiens 0.045 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17105&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732263 46509536 ZINC14963089 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30827 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)C(N)=O)c1Cl InChI=1S/C21H18Cl3N5O4S/c1-29(21(25)32)8-10-9-34-18(16(10)24)20(31)28-17-13(5-12(23)6-14(17)33-2)19(30)27-15-4-3-11(22)7-26-15/h3-7,9H,8H2,1-2H3,(H2,25,32)(H,28,31)(H,26,27,30) FYVUKKKQEZLHIO-UHFFFAOYSA-N 17106 4-{[carbamoyl(methyl)amino]methyl}-3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 12b Coagulation factor X Homo sapiens 0.026 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17106&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732265 46517335 ZINC14963093 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30828 CCNC(=O)N(C)Cc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl InChI=1S/C23H22Cl3N5O4S/c1-4-27-23(34)31(2)10-12-11-36-20(18(12)26)22(33)30-19-15(7-14(25)8-16(19)35-3)21(32)29-17-6-5-13(24)9-28-17/h5-9,11H,4,10H2,1-3H3,(H,27,34)(H,30,33)(H,28,29,32) GZEOQAVNIFNYJR-UHFFFAOYSA-N 17107 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[(ethylcarbamoyl)(methyl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 12c Coagulation factor X Homo sapiens 0.020 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17107&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732266 46517336 ZINC01490172 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30829 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)C(=O)NCCO)c1Cl InChI=1S/C23H22Cl3N5O5S/c1-31(23(35)27-5-6-32)10-12-11-37-20(18(12)26)22(34)30-19-15(7-14(25)8-16(19)36-2)21(33)29-17-4-3-13(24)9-28-17/h3-4,7-9,11,32H,5-6,10H2,1-2H3,(H,27,35)(H,30,34)(H,28,29,33) RTZIXXQWZLORDX-UHFFFAOYSA-N 17108 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-({[(2-hydroxyethyl)carbamoyl](methyl)amino}methyl)thiophene-2-carboxamide::Thiophene-Anthranilamide, 12d Coagulation factor X Homo sapiens 0.050 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17108&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732268 46517337 C04080 ZINC14963097 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30830 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)C(=O)NCCN2CCCC2)c1Cl InChI=1S/C27H29Cl3N6O4S/c1-35(27(39)31-7-10-36-8-3-4-9-36)14-16-15-41-24(22(16)30)26(38)34-23-19(11-18(29)12-20(23)40-2)25(37)33-21-6-5-17(28)13-32-21/h5-6,11-13,15H,3-4,7-10,14H2,1-2H3,(H,31,39)(H,34,38)(H,32,33,37) NAGOBWIFPKZEKG-UHFFFAOYSA-N 17109 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[methyl({[2-(pyrrolidin-1-yl)ethyl]carbamoyl})amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 12e Coagulation factor X Homo sapiens 0.036 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17109&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732402 46517338 ZINC28655647 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30831 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)C(=O)NCCC(O)=O)c1Cl InChI=1S/C24H22Cl3N5O6S/c1-32(24(37)28-6-5-18(33)34)10-12-11-39-21(19(12)27)23(36)31-20-15(7-14(26)8-16(20)38-2)22(35)30-17-4-3-13(25)9-29-17/h3-4,7-9,11H,5-6,10H2,1-2H3,(H,28,37)(H,31,36)(H,33,34)(H,29,30,35) FELBYTMOKIFCKJ-UHFFFAOYSA-N 17110 3-[({[4-chloro-5-({4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}carbamoyl)thiophen-3-yl]methyl}(methyl)carbamoyl)amino]propanoic acid::Thiophene-Anthranilamide, 12f Coagulation factor X Homo sapiens 0.022 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17110&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732404 46517339 ZINC14963101 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30832 COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)C2=NCCO2)c1Cl InChI=1S/C23H20Cl3N5O4S/c1-31(23-27-5-6-35-23)10-12-11-36-20(18(12)26)22(33)30-19-15(7-14(25)8-16(19)34-2)21(32)29-17-4-3-13(24)9-28-17/h3-4,7-9,11H,5-6,10H2,1-2H3,(H,30,33)(H,28,29,32) FBXIHZSULWMHJY-UHFFFAOYSA-N 17111 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[4,5-dihydro-1,3-oxazol-2-yl(methyl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 13a::ZK 810388::ZK810388 Coagulation factor X Homo sapiens 0.007 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17111&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search XLD 1MQ6 3400921 46517340 ZINC01493808 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 30833 CCN(Cc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl)C1=NCCO1 InChI=1S/C24H22Cl3N5O4S/c1-3-32(24-28-6-7-36-24)11-13-12-37-21(19(13)27)23(34)31-20-16(8-15(26)9-17(20)35-2)22(33)30-18-5-4-14(25)10-29-18/h4-5,8-10,12H,3,6-7,11H2,1-2H3,(H,31,34)(H,29,30,33) FJRVGBKCMMRPKF-UHFFFAOYSA-N 17112 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[4,5-dihydro-1,3-oxazol-2-yl(ethyl)amino]methyl}thiophene-2-carboxamide::Thiophene-Anthranilamide, 13b Coagulation factor X Homo sapiens 0.012 Curated from the literature by BindingDB 10.1021/jm070125f 10.7270/Q2J101F5 17536795 aid1797584 Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17112&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16732406 46517341 ZINC14963105 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26472 NC(N)=[NH+]c1ccc(NC(=O)c2cc3ccccc3cc2O)cn1 InChI=1S/C17H15N5O2/c18-17(19)22-15-6-5-12(9-20-15)21-16(24)13-7-10-3-1-2-4-11(10)8-14(13)23/h1-9,23H,(H,21,24)(H4,18,19,20,22)/p+1 SZQFYAPCRCWOFA-UHFFFAOYSA-O 14479 CA-21::[amino({5-[(3-hydroxynaphthalene-2-)amido]pyridin-2-yl}amino)methylidene]azanium Coagulation factor X Homo sapiens 70000 Curated from the literature by BindingDB 10.1016/j.jmb.2004.09.032 10.7270/Q2V40SF3 15522303 aid1797227 Katz, BA; Luong, C; Ho, JD; Somoza, JR; Gjerstad, E; Tang, J; Williams, SR; Verner, E; Mackman, RL; Young, WB; Sprengeler, PA; Chan, H; Mortara, K; Janc, JW; McGrath, ME Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14479&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23644682 46509443 ZINC13444488 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26473 NC(N)=[NH+]c1ccc(NC(=O)c2cc3ccccc3cc2O)cc1 InChI=1S/C18H16N4O2/c19-18(20)22-14-7-5-13(6-8-14)21-17(24)15-9-11-3-1-2-4-12(11)10-16(15)23/h1-10,23H,(H,21,24)(H4,19,20,22)/p+1 FJRJJQARSDVKDS-UHFFFAOYSA-O 14480 CA-22::[amino({4-[(3-hydroxynaphthalene-2-)amido]phenyl}amino)methylidene]azanium Coagulation factor X Homo sapiens >450000 Curated from the literature by BindingDB 10.1016/j.jmb.2004.09.032 10.7270/Q2V40SF3 15522303 aid1797227 Katz, BA; Luong, C; Ho, JD; Somoza, JR; Gjerstad, E; Tang, J; Williams, SR; Verner, E; Mackman, RL; Young, WB; Sprengeler, PA; Chan, H; Mortara, K; Janc, JW; McGrath, ME Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14480&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646779 46514819 ZINC13444467 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26474 NC(N)=[NH+]c1ccc(NC(=O)c2cc3ccccc3c(O)c2O)cn1 InChI=1S/C17H15N5O3/c18-17(19)22-13-6-5-10(8-20-13)21-16(25)12-7-9-3-1-2-4-11(9)14(23)15(12)24/h1-8,23-24H,(H,21,25)(H4,18,19,20,22)/p+1 IVSIFBWEBFSPED-UHFFFAOYSA-O 14481 CA-23::[amino({5-[(3,4-dihydroxynaphthalene-2-)amido]pyridin-2-yl}amino)methylidene]azanium Coagulation factor X Homo sapiens 80000 Curated from the literature by BindingDB 10.1016/j.jmb.2004.09.032 10.7270/Q2V40SF3 15522303 aid1797227 Katz, BA; Luong, C; Ho, JD; Somoza, JR; Gjerstad, E; Tang, J; Williams, SR; Verner, E; Mackman, RL; Young, WB; Sprengeler, PA; Chan, H; Mortara, K; Janc, JW; McGrath, ME Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14481&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646780 46514820 ZINC14955873 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26475 Nc1[nH]c2ccc(NC(=O)c3cc4ccccc4cc3O)cc2[nH+]1 InChI=1S/C18H14N4O2/c19-18-21-14-6-5-12(9-15(14)22-18)20-17(24)13-7-10-3-1-2-4-11(10)8-16(13)23/h1-9,23H,(H,20,24)(H3,19,21,22)/p+1 LDVGDJNFYHOIPH-UHFFFAOYSA-O 14482 2-amino-5-[(3-hydroxynaphthalene-2-)amido]-1H-1,3-benzodiazol-3-ium::CA-24 Coagulation factor X Homo sapiens 200000 Curated from the literature by BindingDB 10.1016/j.jmb.2004.09.032 10.7270/Q2V40SF3 15522303 aid1797227 Katz, BA; Luong, C; Ho, JD; Somoza, JR; Gjerstad, E; Tang, J; Williams, SR; Verner, E; Mackman, RL; Young, WB; Sprengeler, PA; Chan, H; Mortara, K; Janc, JW; McGrath, ME Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14482&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646782 46514821 ZINC14955877 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26476 Nc1[nH]c2ccc(NC(=O)c3cccc(-c4ccccc4)c3O)cc2[nH+]1 InChI=1S/C20H16N4O2/c21-20-23-16-10-9-13(11-17(16)24-20)22-19(26)15-8-4-7-14(18(15)25)12-5-2-1-3-6-12/h1-11,25H,(H,22,26)(H3,21,23,24)/p+1 USQJNQXMUDZZON-UHFFFAOYSA-O 14483 2-amino-5-[(2-hydroxy-3-phenylbenzene)amido]-1H-1,3-benzodiazol-3-ium::CA-25 Coagulation factor X Homo sapiens >450000 Curated from the literature by BindingDB 10.1016/j.jmb.2004.09.032 10.7270/Q2V40SF3 15522303 aid1797227 Katz, BA; Luong, C; Ho, JD; Somoza, JR; Gjerstad, E; Tang, J; Williams, SR; Verner, E; Mackman, RL; Young, WB; Sprengeler, PA; Chan, H; Mortara, K; Janc, JW; McGrath, ME Celera http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14483&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646784 46514822 ZINC14955882 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26493 CC(C)Nc1ccc(-c2cc(N)cc(c2)C(O)=O)n(CC(=O)NCc2ccc(cc2)C(N)=N)c1=O InChI=1S/C25H28N6O4/c1-14(2)30-20-7-8-21(17-9-18(25(34)35)11-19(26)10-17)31(24(20)33)13-22(32)29-12-15-3-5-16(6-4-15)23(27)28/h3-11,14,30H,12-13,26H2,1-2H3,(H3,27,28)(H,29,32)(H,34,35) ZCPXZBSZFSAVGC-UHFFFAOYSA-N 14495 2-Pyridone 14a::3-amino-5-[1-({[(4-carbamimidoylphenyl)methyl]carbamoyl}methyl)-6-oxo-5-(propan-2-ylamino)-1,6-dihydropyridin-2-yl]benzoic acid::3-amino-5-[1-[2-({4-[amino(imino)methyl]benzyl}amino)-2-oxoethyl]-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl]benzoic acid Coagulation factor X Homo sapiens >30000 8 22.00 C Curated from the literature by BindingDB 10.1021/jm0301686 10.7270/Q2KK992S 14561089 aid1797237 Parlow, JJ; Kurumbail, RG; Stegeman, RA; Stevens, AM; Stallings, WC; South, MS Pharmacia Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14495&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9982431 46514831 ZINC13528352 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26494 CC(C)Nc1ccc(-c2cc(N)cc(N)c2)n(CC(=O)NCc2ccc(cc2)C(N)=N)c1=O InChI=1S/C24H29N7O2/c1-14(2)30-20-7-8-21(17-9-18(25)11-19(26)10-17)31(24(20)33)13-22(32)29-12-15-3-5-16(6-4-15)23(27)28/h3-11,14,30H,12-13,25-26H2,1-2H3,(H3,27,28)(H,29,32) RSRFHMTXQRECCQ-UHFFFAOYSA-N 14497 2-Pyridone 14b::N-[(4-carbamimidoylphenyl)methyl]-2-[6-(3,5-diaminophenyl)-2-oxo-3-(propan-2-ylamino)-1,2-dihydropyridin-1-yl]acetamide::N-{4-[Amino(imino)methyl]benzyl}-2-[6-(3,5-diaminophenyl)-3-(isopropylamino)-2-oxopyridin-1(2H)-yl]acetamide Coagulation factor X Homo sapiens >30000 8 22.00 C Curated from the literature by BindingDB 10.1021/jm0301686 10.7270/Q2KK992S 14561089 aid1797237 Parlow, JJ; Kurumbail, RG; Stegeman, RA; Stevens, AM; Stallings, WC; South, MS Pharmacia Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14497&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10072299 46514832 ZINC13528354 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28767 CN1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C23H23ClN4O2S/c1-27-10-8-16(9-11-27)25-23(29)19-12-15-4-2-3-5-18(15)28(19)14-17-13-20(30-26-17)21-6-7-22(24)31-21/h2-7,12-13,16H,8-11,14H2,1H3,(H,25,29) GZYLKYFEFKEDRG-UHFFFAOYSA-N 15823 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-(1-methylpiperidin-4-yl)-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 7 Coagulation factor X Homo sapiens 40 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15823&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801139 46516096 ZINC14959610 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28768 CCN1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C24H25ClN4O2S/c1-2-28-11-9-17(10-12-28)26-24(30)20-13-16-5-3-4-6-19(16)29(20)15-18-14-21(31-27-18)22-7-8-23(25)32-22/h3-8,13-14,17H,2,9-12,15H2,1H3,(H,26,30) ZBYUTHMPEVJBEL-UHFFFAOYSA-N 15824 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-(1-ethylpiperidin-4-yl)-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 8 Coagulation factor X Homo sapiens 18 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15824&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10412365 46516097 ZINC14959615 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28769 CCCN1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C25H27ClN4O2S/c1-2-11-29-12-9-18(10-13-29)27-25(31)21-14-17-5-3-4-6-20(17)30(21)16-19-15-22(32-28-19)23-7-8-24(26)33-23/h3-8,14-15,18H,2,9-13,16H2,1H3,(H,27,31) WKYZTNUDHMDOAY-UHFFFAOYSA-N 15825 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-(1-propylpiperidin-4-yl)-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 9 Coagulation factor X Homo sapiens 64 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15825&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801142 46516098 ZINC14959619 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28770 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C25H27ClN4O2S/c1-16(2)29-11-9-18(10-12-29)27-25(31)21-13-17-5-3-4-6-20(17)30(21)15-19-14-22(32-28-19)23-7-8-24(26)33-23/h3-8,13-14,16,18H,9-12,15H2,1-2H3,(H,27,31) MMGXOGPDBICRQF-UHFFFAOYSA-N 12372 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 1::2-carboxyindole 22::2-carboxyindole-based inhibitor 10 Coagulation factor X Homo sapiens 3 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12372&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search IIA 2BOH 6540265 46512842 ZINC13646511 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28771 CCC(CC)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C27H31ClN4O2S/c1-3-21(4-2)31-13-11-19(12-14-31)29-27(33)23-15-18-7-5-6-8-22(18)32(23)17-20-16-24(34-30-20)25-9-10-26(28)35-25/h5-10,15-16,19,21H,3-4,11-14,17H2,1-2H3,(H,29,33) NMVYRPFVNMJQPF-UHFFFAOYSA-N 15826 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(pentan-3-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 11 Coagulation factor X Homo sapiens 220 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15826&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801110 46516099 ZINC14959624 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28772 CC(C)CN1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C26H29ClN4O2S/c1-17(2)15-30-11-9-19(10-12-30)28-26(32)22-13-18-5-3-4-6-21(18)31(22)16-20-14-23(33-29-20)24-7-8-25(27)34-24/h3-8,13-14,17,19H,9-12,15-16H2,1-2H3,(H,28,32) JRJAYUPBVNFANK-UHFFFAOYSA-N 15827 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(2-methylpropyl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 12 Coagulation factor X Homo sapiens 142 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15827&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801125 46516100 ZINC14959628 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28773 Clc1ccc(s1)-c1cc(Cn2c(cc3ccccc23)C(=O)NC2CCN(CC2)C2CC2)no1 InChI=1S/C25H25ClN4O2S/c26-24-8-7-23(33-24)22-14-18(28-32-22)15-30-20-4-2-1-3-16(20)13-21(30)25(31)27-17-9-11-29(12-10-17)19-5-6-19/h1-4,7-8,13-14,17,19H,5-6,9-12,15H2,(H,27,31) XDHLEMSKBSBEDC-UHFFFAOYSA-N 15828 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-(1-cyclopropylpiperidin-4-yl)-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 13 Coagulation factor X Homo sapiens 27 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15828&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801121 46516101 ZINC14959632 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28774 Clc1ccc(s1)-c1cc(Cn2c(cc3ccccc23)C(=O)NC2CCN(CC2)C2CCCC2)no1 InChI=1S/C27H29ClN4O2S/c28-26-10-9-25(35-26)24-16-20(30-34-24)17-32-22-8-4-1-5-18(22)15-23(32)27(33)29-19-11-13-31(14-12-19)21-6-2-3-7-21/h1,4-5,8-10,15-16,19,21H,2-3,6-7,11-14,17H2,(H,29,33) HRXHFNVTHGOHAS-UHFFFAOYSA-N 15829 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-(1-cyclopentylpiperidin-4-yl)-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 14 Coagulation factor X Homo sapiens 71 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15829&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801120 46516102 ZINC14959636 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28775 Clc1ccc(s1)-c1cc(Cn2c(cc3ccccc23)C(=O)NC2CCN(CC2)C2CCCCC2)no1 InChI=1S/C28H31ClN4O2S/c29-27-11-10-26(36-27)25-17-21(31-35-25)18-33-23-9-5-4-6-19(23)16-24(33)28(34)30-20-12-14-32(15-13-20)22-7-2-1-3-8-22/h4-6,9-11,16-17,20,22H,1-3,7-8,12-15,18H2,(H,30,34) MTUYNQQKDJKGGI-UHFFFAOYSA-N 15830 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-(1-cyclohexylpiperidin-4-yl)-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 15 Coagulation factor X Homo sapiens 106 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15830&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801119 46516103 ZINC14959641 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28776 CC(C)NC1CCN(CC1)C(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C25H27ClN4O2S/c1-16(2)27-18-9-11-29(12-10-18)25(31)21-13-17-5-3-4-6-20(17)30(21)15-19-14-22(32-28-19)23-7-8-24(26)33-23/h3-8,13-14,16,18,27H,9-12,15H2,1-2H3 HAHDTUXAQNSETN-UHFFFAOYSA-N 15831 1-[(1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-1H-indol-2-yl)carbonyl]-N-(propan-2-yl)piperidin-4-amine::2-carboxyindole-based inhibitor 16 Coagulation factor X Homo sapiens 2997 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15831&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22394472 46516104 ZINC14959645 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28777 CC(C)N1CCC(CNC(=O)c2cc3ccccc3n2Cc2cc(on2)-c2ccc(Cl)s2)CC1 InChI=1S/C26H29ClN4O2S/c1-17(2)30-11-9-18(10-12-30)15-28-26(32)22-13-19-5-3-4-6-21(19)31(22)16-20-14-23(33-29-20)24-7-8-25(27)34-24/h3-8,13-14,17-18H,9-12,15-16H2,1-2H3,(H,28,32) OYIDOIKTXHNHIG-UHFFFAOYSA-N 15832 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-{[1-(propan-2-yl)piperidin-4-yl]methyl}-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 17 Coagulation factor X Homo sapiens 161 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15832&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801137 46516105 ZINC14959650 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28778 OCCN1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C24H25ClN4O3S/c25-23-6-5-22(33-23)21-14-18(27-32-21)15-29-19-4-2-1-3-16(19)13-20(29)24(31)26-17-7-9-28(10-8-17)11-12-30/h1-6,13-14,17,30H,7-12,15H2,(H,26,31) VDDFTMCWBWLRRC-UHFFFAOYSA-N 15833 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(2-hydroxyethyl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 18 Coagulation factor X Homo sapiens 131 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15833&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801115 46516106 ZINC14959654 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28779 Clc1ccc(s1)-c1cc(Cn2c(cc3ccccc23)C(=O)NC2CCN(CC2)C2CCOCC2)no1 InChI=1S/C27H29ClN4O3S/c28-26-6-5-25(36-26)24-16-20(30-35-24)17-32-22-4-2-1-3-18(22)15-23(32)27(33)29-19-7-11-31(12-8-19)21-9-13-34-14-10-21/h1-6,15-16,19,21H,7-14,17H2,(H,29,33) SVPMYJVMCNPHDZ-UHFFFAOYSA-N 15834 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(oxan-4-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 19 Coagulation factor X Homo sapiens 95 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15834&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801144 46516107 ZINC14959658 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28780 CC(=O)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C24H23ClN4O3S/c1-15(30)28-10-8-17(9-11-28)26-24(31)20-12-16-4-2-3-5-19(16)29(20)14-18-13-21(32-27-18)22-6-7-23(25)33-22/h2-7,12-13,17H,8-11,14H2,1H3,(H,26,31) GLLJZAWLZCAMDT-UHFFFAOYSA-N 15835 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-(1-acetylpiperidin-4-yl)-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 20 Coagulation factor X Homo sapiens 763 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15835&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801207 46516108 ZINC14959663 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28785 CS(=O)(=O)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C23H23ClN4O4S2/c1-34(30,31)27-10-8-16(9-11-27)25-23(29)19-12-15-4-2-3-5-18(15)28(19)14-17-13-20(32-26-17)21-6-7-22(24)33-21/h2-7,12-13,16H,8-11,14H2,1H3,(H,25,29) DSSBUSBGXAYFEJ-UHFFFAOYSA-N 15836 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-(1-methanesulfonylpiperidin-4-yl)-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 21 Coagulation factor X Homo sapiens 125 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15836&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801141 46516109 ZINC14959667 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28786 NC(=O)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C23H22ClN5O3S/c24-21-6-5-20(33-21)19-12-16(27-32-19)13-29-17-4-2-1-3-14(17)11-18(29)22(30)26-15-7-9-28(10-8-15)23(25)31/h1-6,11-12,15H,7-10,13H2,(H2,25,31)(H,26,30) DNLIPQVJNZNUCJ-UHFFFAOYSA-N 15837 2-carboxyindole-based inhibitor 22::N-(1-carbamoylpiperidin-4-yl)-1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-1H-indole-2-carboxamide Coagulation factor X Homo sapiens 1075 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15837&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801208 46516110 ZINC14959672 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28787 CC(C)N1CC[C@@H](C1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C24H25ClN4O2S/c1-15(2)28-10-9-17(13-28)26-24(30)20-11-16-5-3-4-6-19(16)29(20)14-18-12-21(31-27-18)22-7-8-23(25)32-22/h3-8,11-12,15,17H,9-10,13-14H2,1-2H3,(H,26,30)/t17-/m0/s1 XDOHRNCCDDHHBW-KRWDZBQOSA-N 15838 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[(3S)-1-(propan-2-yl)pyrrolidin-3-yl]-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 23 Coagulation factor X Homo sapiens 103 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15838&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647193 46516111 ZINC14959678 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28788 CC(C)N1CC[C@H](C1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C24H25ClN4O2S/c1-15(2)28-10-9-17(13-28)26-24(30)20-11-16-5-3-4-6-19(16)29(20)14-18-12-21(31-27-18)22-7-8-23(25)32-22/h3-8,11-12,15,17H,9-10,13-14H2,1-2H3,(H,26,30)/t17-/m1/s1 XDOHRNCCDDHHBW-QGZVFWFLSA-N 15839 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[(3R)-1-(propan-2-yl)pyrrolidin-3-yl]-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 24 Coagulation factor X Homo sapiens 48 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15839&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647194 46516112 ZINC14959682 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28789 CC(C)N1CC(C1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C23H23ClN4O2S/c1-14(2)27-11-17(12-27)25-23(29)19-9-15-5-3-4-6-18(15)28(19)13-16-10-20(30-26-16)21-7-8-22(24)31-21/h3-10,14,17H,11-13H2,1-2H3,(H,25,29) ALVPSRKMFSCXAQ-UHFFFAOYSA-N 15840 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(propan-2-yl)azetidin-3-yl]-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 25 Coagulation factor X Homo sapiens 225 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15840&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647195 46516113 ZINC14959687 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28790 CC(C)CN1CC(C1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C24H25ClN4O2S/c1-15(2)11-28-12-18(13-28)26-24(30)20-9-16-5-3-4-6-19(16)29(20)14-17-10-21(31-27-17)22-7-8-23(25)32-22/h3-10,15,18H,11-14H2,1-2H3,(H,26,30) RZIQGXBHLUAODK-UHFFFAOYSA-N 15841 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(2-methylpropyl)azetidin-3-yl]-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 26 Coagulation factor X Homo sapiens 345 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15841&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647196 46516114 ZINC14959691 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28791 CC(C)N1CC(CNC(=O)c2cc3ccccc3n2Cc2cc(on2)-c2ccc(Cl)s2)C1 InChI=1S/C24H25ClN4O2S/c1-15(2)28-12-16(13-28)11-26-24(30)20-9-17-5-3-4-6-19(17)29(20)14-18-10-21(31-27-18)22-7-8-23(25)32-22/h3-10,15-16H,11-14H2,1-2H3,(H,26,30) JXXTUZLDPFLPSN-UHFFFAOYSA-N 15842 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-{[1-(propan-2-yl)azetidin-3-yl]methyl}-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 27 Coagulation factor X Homo sapiens 839 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15842&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647197 46516115 ZINC14959696 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28792 Clc1ccc(s1)-c1cc(Cn2c(cc3ccccc23)C(=O)NC2CCN(CC2)c2ccncc2)no1 InChI=1S/C27H24ClN5O2S/c28-26-6-5-25(36-26)24-16-20(31-35-24)17-33-22-4-2-1-3-18(22)15-23(33)27(34)30-19-9-13-32(14-10-19)21-7-11-29-12-8-21/h1-8,11-12,15-16,19H,9-10,13-14,17H2,(H,30,34) VGXIAQUUVIGDPS-UHFFFAOYSA-N 15843 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(pyridin-4-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 28 Coagulation factor X Homo sapiens 14 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15843&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10391881 46516116 ZINC14959701 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28793 Clc1ccc(s1)-c1cc(Cn2c(cc3ccccc23)C(=O)NC2CCN(CC2)c2ccncn2)no1 InChI=1S/C26H23ClN6O2S/c27-24-6-5-23(36-24)22-14-19(31-35-22)15-33-20-4-2-1-3-17(20)13-21(33)26(34)30-18-8-11-32(12-9-18)25-7-10-28-16-29-25/h1-7,10,13-14,16,18H,8-9,11-12,15H2,(H,30,34) NNWDHTFSPUCMQQ-UHFFFAOYSA-N 15844 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(pyrimidin-4-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 29 Coagulation factor X Homo sapiens 95 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15844&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801143 46516117 ZINC14959706 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28794 Clc1ccc(s1)-c1cc(Cn2c(cc3ccccc23)C(=O)NCC2CCN(CC2)c2ccncc2)no1 InChI=1S/C28H26ClN5O2S/c29-27-6-5-26(37-27)25-16-21(32-36-25)18-34-23-4-2-1-3-20(23)15-24(34)28(35)31-17-19-9-13-33(14-10-19)22-7-11-30-12-8-22/h1-8,11-12,15-16,19H,9-10,13-14,17-18H2,(H,31,35) RASORPKPULRQAN-UHFFFAOYSA-N 15845 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 30 Coagulation factor X Homo sapiens 64 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15845&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801117 46516118 ZINC14959710 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28795 Clc1ccc(s1)-c1cc(Cn2c(cc3ccccc23)C(=O)N2CCC(CC2)Nc2ccncc2)no1 InChI=1S/C27H24ClN5O2S/c28-26-6-5-25(36-26)24-16-21(31-35-24)17-33-22-4-2-1-3-18(22)15-23(33)27(34)32-13-9-20(10-14-32)30-19-7-11-29-12-8-19/h1-8,11-12,15-16,20H,9-10,13-14,17H2,(H,29,30) MGMRQNKJMRCNMF-UHFFFAOYSA-N 15846 2-carboxyindole-based inhibitor 31::N-{1-[(1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-1H-indol-2-yl)carbonyl]piperidin-4-yl}pyridin-4-amine Coagulation factor X Homo sapiens 18 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15846&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22394409 46516119 ZINC14959715 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28796 Clc1ccc(s1)-c1cc(Cn2c(cc3ccccc23)C(=O)N2CCC(CC2)Oc2ccncc2)no1 InChI=1S/C27H23ClN4O3S/c28-26-6-5-25(36-26)24-16-19(30-35-24)17-32-22-4-2-1-3-18(22)15-23(32)27(33)31-13-9-21(10-14-31)34-20-7-11-29-12-8-20/h1-8,11-12,15-16,21H,9-10,13-14,17H2 UPZFSDPZCQPKHL-UHFFFAOYSA-N 15847 2-carboxyindole-based inhibitor 32::5-(5-chlorothiophen-2-yl)-3-[(2-{[4-(pyridin-4-yloxy)piperidin-1-yl]carbonyl}-1H-indol-1-yl)methyl]-1,2-oxazole Coagulation factor X Homo sapiens 2900 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15847&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22394327 46516120 ZINC14959719 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28797 Clc1ccc(s1)-c1cc(Cn2c(cc3ccccc23)C(=O)NC2CN(C2)c2ccncc2)no1 InChI=1S/C25H20ClN5O2S/c26-24-6-5-23(34-24)22-12-17(29-33-22)15-31-20-4-2-1-3-16(20)11-21(31)25(32)28-18-13-30(14-18)19-7-9-27-10-8-19/h1-12,18H,13-15H2,(H,28,32) OVIAMVWKKVORLD-UHFFFAOYSA-N 15848 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(pyridin-4-yl)azetidin-3-yl]-1H-indole-2-carboxamide::2-carboxyindole-based inhibitor 33 Coagulation factor X Homo sapiens 12 Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.019 10.7270/Q2610XKM 15261269 aid1797435 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15848&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647198 46516121 ZINC14959724 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28802 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1-c1ccc(Cl)cc1 InChI=1S/C23H26ClN3O/c1-16(2)26-13-11-19(12-14-26)25-23(28)22-15-17-5-3-4-6-21(17)27(22)20-9-7-18(24)8-10-20/h3-10,15-16,19H,11-14H2,1-2H3,(H,25,28) PJTYIXSRDGSRKB-UHFFFAOYSA-N 15849 1-(4-chlorophenyl)-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 8 Coagulation factor X Homo sapiens 2100 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15849&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801082 46516122 ZINC14959729 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28803 COc1cccc(c1)-n1c(cc2ccccc12)C(=O)NC1CCN(CC1)C(C)C InChI=1S/C24H29N3O2/c1-17(2)26-13-11-19(12-14-26)25-24(28)23-15-18-7-4-5-10-22(18)27(23)20-8-6-9-21(16-20)29-3/h4-10,15-17,19H,11-14H2,1-3H3,(H,25,28) BVSIBCJUGIVAKQ-UHFFFAOYSA-N 15850 1-(3-methoxyphenyl)-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 9 Coagulation factor X Homo sapiens 2480 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15850&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801212 46516123 ZINC14959732 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28804 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1-c1cccc(Cl)c1 InChI=1S/C23H26ClN3O/c1-16(2)26-12-10-19(11-13-26)25-23(28)22-14-17-6-3-4-9-21(17)27(22)20-8-5-7-18(24)15-20/h3-9,14-16,19H,10-13H2,1-2H3,(H,25,28) AYWFFTBSKJPXKS-UHFFFAOYSA-N 15851 1-(3-chlorophenyl)-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 10 Coagulation factor X Homo sapiens 9010 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15851&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801048 46516124 ZINC14959736 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28805 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1ccc(Cl)cc1 InChI=1S/C24H28ClN3O/c1-17(2)27-13-11-21(12-14-27)26-24(29)23-15-19-5-3-4-6-22(19)28(23)16-18-7-9-20(25)10-8-18/h3-10,15,17,21H,11-14,16H2,1-2H3,(H,26,29) FXQMOQVEXWRJHX-UHFFFAOYSA-N 15852 1-[(4-chlorophenyl)methyl]-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 11 Coagulation factor X Homo sapiens 2500 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15852&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801076 46516125 ZINC14959740 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28806 COc1cccc(Cn2c(cc3ccccc23)C(=O)NC2CCN(CC2)C(C)C)c1 InChI=1S/C25H31N3O2/c1-18(2)27-13-11-21(12-14-27)26-25(29)24-16-20-8-4-5-10-23(20)28(24)17-19-7-6-9-22(15-19)30-3/h4-10,15-16,18,21H,11-14,17H2,1-3H3,(H,26,29) GIPCBGDQVGKMPO-UHFFFAOYSA-N 12398 1-(3-Methoxy-benzyl)-1H-indole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide::1-[(3-methoxyphenyl)methyl]-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 43::2-carboxyindole 12 Coagulation factor X Homo sapiens 89 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12398&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search IID 2BQ7 6540267 46512867 DB07973 ZINC12355093 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28807 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cccc(Cl)c1 InChI=1S/C24H28ClN3O/c1-17(2)27-12-10-21(11-13-27)26-24(29)23-15-19-7-3-4-9-22(19)28(23)16-18-6-5-8-20(25)14-18/h3-9,14-15,17,21H,10-13,16H2,1-2H3,(H,26,29) LGFMFSIKXFRKMB-UHFFFAOYSA-N 15853 1-[(3-chlorophenyl)methyl]-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 13 Coagulation factor X Homo sapiens 654 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15853&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801045 46516126 ZINC14959743 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28808 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1CCc1ccc(Cl)cc1 InChI=1S/C25H30ClN3O/c1-18(2)28-14-12-22(13-15-28)27-25(30)24-17-20-5-3-4-6-23(20)29(24)16-11-19-7-9-21(26)10-8-19/h3-10,17-18,22H,11-16H2,1-2H3,(H,27,30) QOTVVZPQBGZYFT-UHFFFAOYSA-N 15854 1-[2-(4-chlorophenyl)ethyl]-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 14 Coagulation factor X Homo sapiens 73 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15854&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801009 46516127 ZINC14959747 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28809 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1CCc1ccc(Cl)cc1Cl InChI=1S/C25H29Cl2N3O/c1-17(2)29-12-10-21(11-13-29)28-25(31)24-15-19-5-3-4-6-23(19)30(24)14-9-18-7-8-20(26)16-22(18)27/h3-8,15-17,21H,9-14H2,1-2H3,(H,28,31) DLMIMIWKEZCOGZ-UHFFFAOYSA-N 15855 1-[2-(2,4-dichlorophenyl)ethyl]-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 15 Coagulation factor X Homo sapiens 474 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15855&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801005 46516128 ZINC14959751 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28810 COc1cccc(CCn2c(cc3ccccc23)C(=O)NC2CCN(CC2)C(C)C)c1 InChI=1S/C26H33N3O2/c1-19(2)28-14-12-22(13-15-28)27-26(30)25-18-21-8-4-5-10-24(21)29(25)16-11-20-7-6-9-23(17-20)31-3/h4-10,17-19,22H,11-16H2,1-3H3,(H,27,30) QZHQPTPQLDIMDW-UHFFFAOYSA-N 15856 1-[2-(3-methoxyphenyl)ethyl]-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 16 Coagulation factor X Homo sapiens >10000 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15856&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801210 46516129 ZINC14959755 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28811 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc2ccc(Cl)cc2s1 InChI=1S/C26H28ClN3OS/c1-17(2)29-11-9-21(10-12-29)28-26(31)24-14-18-5-3-4-6-23(18)30(24)16-22-13-19-7-8-20(27)15-25(19)32-22/h3-8,13-15,17,21H,9-12,16H2,1-2H3,(H,28,31) PQDRFBZXRKOETO-UHFFFAOYSA-N 15857 1-[(6-chloro-1-benzothiophen-2-yl)methyl]-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 17 Coagulation factor X Homo sapiens 40 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15857&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801160 46516130 ZINC14959758 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28812 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)cc1 InChI=1S/C27H29ClN4O2/c1-18(2)31-13-11-22(12-14-31)29-27(33)25-15-20-5-3-4-6-24(20)32(25)17-23-16-26(34-30-23)19-7-9-21(28)10-8-19/h3-10,15-16,18,22H,11-14,17H2,1-2H3,(H,29,33) SORMHIBIVMGENN-UHFFFAOYSA-N 15858 1-{[5-(4-chlorophenyl)-1,2-oxazol-3-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 18 Coagulation factor X Homo sapiens 810 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15858&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801095 46516131 ZINC14959762 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28813 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc(no1)-c1ccc(Cl)cc1 InChI=1S/C27H29ClN4O2/c1-18(2)31-13-11-22(12-14-31)29-27(33)26-15-20-5-3-4-6-25(20)32(26)17-23-16-24(30-34-23)19-7-9-21(28)10-8-19/h3-10,15-16,18,22H,11-14,17H2,1-2H3,(H,29,33) BBOTYKYSYRSDPL-UHFFFAOYSA-N 15859 1-{[3-(4-chlorophenyl)-1,2-oxazol-5-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 19 Coagulation factor X Homo sapiens 400 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15859&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801030 46516132 ZINC14959766 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28814 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1nc(no1)-c1ccc(Cl)cc1 InChI=1S/C26H28ClN5O2/c1-17(2)31-13-11-21(12-14-31)28-26(33)23-15-19-5-3-4-6-22(19)32(23)16-24-29-25(30-34-24)18-7-9-20(27)10-8-18/h3-10,15,17,21H,11-14,16H2,1-2H3,(H,28,33) KFEMNDSSCUFFIG-UHFFFAOYSA-N 15860 1-{[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 20 Coagulation factor X Homo sapiens 2230 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15860&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801029 46516133 ZINC14959770 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28815 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cnc(s1)-c1ccc(Cl)cc1 InChI=1S/C27H29ClN4OS/c1-18(2)31-13-11-22(12-14-31)30-26(33)25-15-20-5-3-4-6-24(20)32(25)17-23-16-29-27(34-23)19-7-9-21(28)10-8-19/h3-10,15-16,18,22H,11-14,17H2,1-2H3,(H,30,33) FTRYLMSDUSKCSS-UHFFFAOYSA-N 15861 1-{[2-(4-chlorophenyl)-1,3-thiazol-5-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 21 Coagulation factor X Homo sapiens 2730 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15861&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647199 46516134 ZINC14959774 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28816 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc(on1)-c1ccc(Cl)s1 InChI=1S/C25H27ClN4O2S/c1-16(2)29-11-9-18(10-12-29)27-25(31)21-13-17-5-3-4-6-20(17)30(21)15-19-14-22(32-28-19)23-7-8-24(26)33-23/h3-8,13-14,16,18H,9-12,15H2,1-2H3,(H,27,31) MMGXOGPDBICRQF-UHFFFAOYSA-N 12372 1-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 1::2-carboxyindole 22::2-carboxyindole-based inhibitor 10 Coagulation factor X Homo sapiens 3 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12372&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search IIA 2BOH 6540265 46512842 ZINC13646511 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28817 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cc(no1)-c1ccc(Cl)s1 InChI=1S/C25H27ClN4O2S/c1-16(2)29-11-9-18(10-12-29)27-25(31)22-13-17-5-3-4-6-21(17)30(22)15-19-14-20(28-32-19)23-7-8-24(26)33-23/h3-8,13-14,16,18H,9-12,15H2,1-2H3,(H,27,31) VBPAXWNURRSMSW-UHFFFAOYSA-N 15862 1-{[3-(5-chlorothiophen-2-yl)-1,2-oxazol-5-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 23 Coagulation factor X Homo sapiens 3 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15862&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801031 46516135 ZINC14959778 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28818 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1nnc(s1)-c1ccc(Cl)s1 InChI=1S/C24H26ClN5OS2/c1-15(2)29-11-9-17(10-12-29)26-23(31)19-13-16-5-3-4-6-18(16)30(19)14-22-27-28-24(33-22)20-7-8-21(25)32-20/h3-8,13,15,17H,9-12,14H2,1-2H3,(H,26,31) GREPHJSRGKVNIG-UHFFFAOYSA-N 15863 1-{[5-(5-chlorothiophen-2-yl)-1,3,4-thiadiazol-2-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 24 Coagulation factor X Homo sapiens 4 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15863&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801097 46516136 ZINC14959782 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28819 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1Cc1cnc(s1)-c1ccc(Cl)s1 InChI=1S/C25H27ClN4OS2/c1-16(2)29-11-9-18(10-12-29)28-24(31)21-13-17-5-3-4-6-20(17)30(21)15-19-14-27-25(32-19)22-7-8-23(26)33-22/h3-8,13-14,16,18H,9-12,15H2,1-2H3,(H,28,31) DBUBLUXPBHYRHZ-UHFFFAOYSA-N 15864 1-{[2-(5-chlorothiophen-2-yl)-1,3-thiazol-5-yl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 25 Coagulation factor X Homo sapiens 57 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15864&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801019 46516137 ZINC14959787 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28820 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1CC(=O)Nc1ccc(Cl)s1 InChI=1S/C23H27ClN4O2S/c1-15(2)27-11-9-17(10-12-27)25-23(30)19-13-16-5-3-4-6-18(16)28(19)14-21(29)26-22-8-7-20(24)31-22/h3-8,13,15,17H,9-12,14H2,1-2H3,(H,25,30)(H,26,29) LBQLDTXJHMXFGR-UHFFFAOYSA-N 15865 1-{[(5-chlorothiophen-2-yl)carbamoyl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 26 Coagulation factor X Homo sapiens 15 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15865&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20801159 46516138 ZINC14959791 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28821 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1CC(=O)Nc1ccc(Cl)cc1 InChI=1S/C25H29ClN4O2/c1-17(2)29-13-11-21(12-14-29)28-25(32)23-15-18-5-3-4-6-22(18)30(23)16-24(31)27-20-9-7-19(26)8-10-20/h3-10,15,17,21H,11-14,16H2,1-2H3,(H,27,31)(H,28,32) BDLMBQRBNPDCSS-UHFFFAOYSA-N 12400 1-[(4-Chloro-phenylcarbamoyl)-methyl]-1H-indole-2-carboxylic acid (1-isopropylpiperidin-4-yl)-amide::1-{[(4-chlorophenyl)carbamoyl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-Carboxyindole Scaffold 45::2-carboxyindole 27 Coagulation factor X Homo sapiens 3 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12400&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search IIE 2BQW 6540268 46512869 DB07974 ZINC13646547 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28822 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1CC(=O)Nc1cccc(Cl)c1 InChI=1S/C25H29ClN4O2/c1-17(2)29-12-10-20(11-13-29)28-25(32)23-14-18-6-3-4-9-22(18)30(23)16-24(31)27-21-8-5-7-19(26)15-21/h3-9,14-15,17,20H,10-13,16H2,1-2H3,(H,27,31)(H,28,32) QIOZPGMOYGXSIH-UHFFFAOYSA-N 15866 1-{[(3-chlorophenyl)carbamoyl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 28 Coagulation factor X Homo sapiens 287 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15866&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647200 46516139 ZINC14959794 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 28823 CC(C)N1CCC(CC1)NC(=O)c1cc2ccccc2n1CC(=O)Nc1ccc(Cl)cn1 InChI=1S/C24H28ClN5O2/c1-16(2)29-11-9-19(10-12-29)27-24(32)21-13-17-5-3-4-6-20(17)30(21)15-23(31)28-22-8-7-18(25)14-26-22/h3-8,13-14,16,19H,9-12,15H2,1-2H3,(H,27,32)(H,26,28,31) ILRJJEMRKWAJMZ-UHFFFAOYSA-N 15867 1-{[(5-chloropyridin-2-yl)carbamoyl]methyl}-N-[1-(propan-2-yl)piperidin-4-yl]-1H-indole-2-carboxamide::2-carboxyindole 29 Coagulation factor X Homo sapiens 1 7.8 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.020 10.7270/Q22805WQ 15261268 aid1797438 Nazare, M; Essrich, M; Will, DW; Matter, H; Ritter, K; Urmann, M; Bauer, A; Schreuder, H; Dudda, A; Czech, J; Lorenz, M; Laux, V; Wehner, V Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15867&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10095455 46516140 ZINC14959798 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26689 CC(C)Nc1nc(Cl)c(-c2cc(N)cc(c2)C(O)=O)n(CC(=O)NCc2ccc(cc2)C(N)=N)c1=O InChI=1S/C24H26ClN7O4/c1-12(2)30-22-23(34)32(11-18(33)29-10-13-3-5-14(6-4-13)21(27)28)19(20(25)31-22)15-7-16(24(35)36)9-17(26)8-15/h3-9,12H,10-11,26H2,1-2H3,(H3,27,28)(H,29,33)(H,30,31)(H,35,36) XDNNQWBDYFHHSY-UHFFFAOYSA-N 14593 3-amino-5-[1-({[(4-carbamimidoylphenyl)methyl]carbamoyl}methyl)-3-chloro-6-oxo-5-(propan-2-ylamino)-1,6-dihydropyrazin-2-yl]benzoic acid::CHEMBL77076::Pyrazinone Analog 34 Coagulation factor X Homo sapiens >100000 Curated from the literature by BindingDB 10.1021/jm030131l 10.7270/Q2FT8J9M 12954058 Parlow, JJ; Case, BL; Dice, TA; Fenton, RL; Hayes, MJ; Jones, DE; Neumann, WL; Wood, RS; Lachance, RM; Girard, TJ; Nicholson, NS; Clare, M; Stegeman, RA; Stevens, AM; Stallings, WC; Kurumbail, RG; South, MS Pharmacia Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14593&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9936190 46514928 CHEMBL77076 ZINC03916277 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26708 NC(=N)c1ccc(CNC(=O)Cc2c(F)ccc(NCCc3ccccc3)c2F)cc1 InChI=1S/C24H24F2N4O/c25-20-10-11-21(29-13-12-16-4-2-1-3-5-16)23(26)19(20)14-22(31)30-15-17-6-8-18(9-7-17)24(27)28/h1-11,29H,12-15H2,(H3,27,28)(H,30,31) MUVZWQIUHJRCSL-UHFFFAOYSA-N 14594 N-[(4-carbamimidoylphenyl)methyl]-2-{2,6-difluoro-3-[(2-phenylethyl)amino]phenyl}acetamide::N-{4-[Amino(imino)methyl]benzyl}-2-{2,6-difluoro-3-[(2-phenylethyl)amino]phenyl}acetamide::Substituted Benzene Analog 30b Coagulation factor X Homo sapiens >30000 8 22.00 C Curated from the literature by BindingDB 10.1021/jm030233b 10.7270/Q2B27SJR 13678408 aid1797261 Parlow, JJ; Stevens, AM; Stegeman, RA; Stallings, WC; Kurumbail, RG; South, MS Pharmacia Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14594&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11015356 46509444 ZINC13527418 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26709 NC(=N)c1ccc(CNC(=O)Cc2c(F)c(NCCc3ccccc3)ccc2-c2ccccc2)cc1 InChI=1S/C30H29FN4O/c31-29-26(19-28(36)35-20-22-11-13-24(14-12-22)30(32)33)25(23-9-5-2-6-10-23)15-16-27(29)34-18-17-21-7-3-1-4-8-21/h1-16,34H,17-20H2,(H3,32,33)(H,35,36) AQUBGXSYJSSYPL-UHFFFAOYSA-N 14595 N-[(4-carbamimidoylphenyl)methyl]-2-{2-fluoro-6-phenyl-3-[(2-phenylethyl)amino]phenyl}acetamide::N-{4-[Amino(imino)methyl]benzyl}-2-{3-fluoro-4-[(2-phenylethyl)amino]-1,1-biphenyl-2-yl}acetamide::Substituted Benzene Analog 50a Coagulation factor X Homo sapiens >30000 8 22.00 C Curated from the literature by BindingDB 10.1021/jm030233b 10.7270/Q2B27SJR 13678408 aid1797261 Parlow, JJ; Stevens, AM; Stegeman, RA; Stallings, WC; Kurumbail, RG; South, MS Pharmacia Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14595&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11059896 46514929 ZINC13527422 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26710 NC(=N)c1ccc(CNC(=O)Cc2c(F)c(NCc3ccccc3)ccc2-c2cccc(N)c2)cc1 InChI=1S/C29H28FN5O/c30-28-25(16-27(36)35-18-20-9-11-21(12-10-20)29(32)33)24(22-7-4-8-23(31)15-22)13-14-26(28)34-17-19-5-2-1-3-6-19/h1-15,34H,16-18,31H2,(H3,32,33)(H,35,36) COQVFDLYAJKUNP-UHFFFAOYSA-N 14596 2-[3-Amino-4-(benzylamino)-3-fluoro-1,1-biphenyl-2-yl]-N-{4-[amino(imino)methyl]benzyl}acetamide::2-[6-(3-aminophenyl)-3-(benzylamino)-2-fluorophenyl]-N-[(4-carbamimidoylphenyl)methyl]acetamide::Substituted Benzene Analog 50b Coagulation factor X Homo sapiens >30000 8 22.00 C Curated from the literature by BindingDB 10.1021/jm030233b 10.7270/Q2B27SJR 13678408 aid1797261 Parlow, JJ; Stevens, AM; Stegeman, RA; Stallings, WC; Kurumbail, RG; South, MS Pharmacia Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14596&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10227730 46514930 ZINC13527428 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26711 CC(C)Nc1ccc(-c2cccc(N)c2)c(CC(=O)NCc2ccc(cc2)C(N)=N)c1F InChI=1S/C25H28FN5O/c1-15(2)31-22-11-10-20(18-4-3-5-19(27)12-18)21(24(22)26)13-23(32)30-14-16-6-8-17(9-7-16)25(28)29/h3-12,15,31H,13-14,27H2,1-2H3,(H3,28,29)(H,30,32) UIFFGJRELUIVDZ-UHFFFAOYSA-N 14597 2-[3-Amino-3-fluoro-4-(isopropylamino)-1,1-biphenyl-2-yl]-N-{4-[amino(imino)methyl]benzyl}acetamide::2-[6-(3-aminophenyl)-2-fluoro-3-(propan-2-ylamino)phenyl]-N-[(4-carbamimidoylphenyl)methyl]acetamide::CHEMBL125781::Substituted Benzene Analog 50c Coagulation factor X Homo sapiens >30000 8 22.00 C Curated from the literature by BindingDB 10.1021/jm030233b 10.7270/Q2B27SJR 13678408 aid1797261 Parlow, JJ; Stevens, AM; Stegeman, RA; Stallings, WC; Kurumbail, RG; South, MS Pharmacia Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14597&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9845742 46514931 CHEMBL125781 ZINC13527431 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26712 COc1c(NCCc2ccccc2)ccc(c1CC(=O)NCc1ccc(cc1)C(N)=N)-c1ccccc1 InChI=1S/C31H32N4O2/c1-37-30-27(20-29(36)35-21-23-12-14-25(15-13-23)31(32)33)26(24-10-6-3-7-11-24)16-17-28(30)34-19-18-22-8-4-2-5-9-22/h2-17,34H,18-21H2,1H3,(H3,32,33)(H,35,36) GXOLLDCZLSCRTK-UHFFFAOYSA-N 14598 N-[(4-carbamimidoylphenyl)methyl]-2-{2-methoxy-6-phenyl-3-[(2-phenylethyl)amino]phenyl}acetamide::N-{4-[Amino(imino)methyl]benzyl}-2-{3-methoxy-4-[(2-phenylethyl)amino]-1,1-biphenyl-2-yl}acetamide::Substituted Benzene Analog 50d Coagulation factor X Homo sapiens >30000 8 22.00 C Curated from the literature by BindingDB 10.1021/jm030233b 10.7270/Q2B27SJR 13678408 aid1797261 Parlow, JJ; Stevens, AM; Stegeman, RA; Stallings, WC; Kurumbail, RG; South, MS Pharmacia Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14598&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11730709 46514932 ZINC13527433 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26713 COc1c(NC(C)C)ccc(-c2ccccc2)c1CC(=O)NCc1ccc(cc1)C(N)=N InChI=1S/C26H30N4O2/c1-17(2)30-23-14-13-21(19-7-5-4-6-8-19)22(25(23)32-3)15-24(31)29-16-18-9-11-20(12-10-18)26(27)28/h4-14,17,30H,15-16H2,1-3H3,(H3,27,28)(H,29,31) YVHLXJWWXOTYST-UHFFFAOYSA-N 14599 CHEMBL333980::N-[(4-carbamimidoylphenyl)methyl]-2-[2-methoxy-6-phenyl-3-(propan-2-ylamino)phenyl]acetamide::N-{4-[Amino(imino)methyl]benzyl}-2-[4-(isopropylamino)-3-methoxy-1,1-biphenyl-2-yl]acetamide::Substituted Benzene Analog 50e Coagulation factor X Homo sapiens >30000 8 22.00 C Curated from the literature by BindingDB 10.1021/jm030233b 10.7270/Q2B27SJR 13678408 aid1797261 Parlow, JJ; Stevens, AM; Stegeman, RA; Stallings, WC; Kurumbail, RG; South, MS Pharmacia Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14599&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11102065 46514933 CHEMBL333980 ZINC13527436 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26714 NC(=N)c1ccc(CNC(=O)Cc2c(O)c(NCCc3ccccc3)ccc2-c2ccccc2)cc1 InChI=1S/C30H30N4O2/c31-30(32)24-13-11-22(12-14-24)20-34-28(35)19-26-25(23-9-5-2-6-10-23)15-16-27(29(26)36)33-18-17-21-7-3-1-4-8-21/h1-16,33,36H,17-20H2,(H3,31,32)(H,34,35) BMKZZNQBNUXUQB-UHFFFAOYSA-N 14600 N-[(4-carbamimidoylphenyl)methyl]-2-{2-hydroxy-6-phenyl-3-[(2-phenylethyl)amino]phenyl}acetamide::N-{4-[Amino(imino)methyl]benzyl}-2-{3-hydroxy-4-[(2-phenylethyl)amino]-1,1-biphenyl-2-yl}acetamide::Substituted Benzene Analog 51 Coagulation factor X Homo sapiens >30000 8 22.00 C Curated from the literature by BindingDB 10.1021/jm030233b 10.7270/Q2B27SJR 13678408 aid1797261 Parlow, JJ; Stevens, AM; Stegeman, RA; Stallings, WC; Kurumbail, RG; South, MS Pharmacia Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14600&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10994432 46514934 ZINC13527439 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26715 CC(C)Nc1ccc(-c2ccccc2)c(CC(=O)NCc2ccc(cc2)C(N)=N)c1O InChI=1S/C25H28N4O2/c1-16(2)29-22-13-12-20(18-6-4-3-5-7-18)21(24(22)31)14-23(30)28-15-17-8-10-19(11-9-17)25(26)27/h3-13,16,29,31H,14-15H2,1-2H3,(H3,26,27)(H,28,30) CTWGJCJJBKHITF-UHFFFAOYSA-N 14601 CHEMBL125585::N-[(4-carbamimidoylphenyl)methyl]-2-[2-hydroxy-6-phenyl-3-(propan-2-ylamino)phenyl]acetamide::N-{4-[Amino(imino)methyl]benzyl}-2-[3-hydroxy-4-(isopropyl)-1,1-biphenyl-2-yl]acetamide::Substituted Benzene Analog 53 Coagulation factor X Homo sapiens >30000 8 22.00 C Curated from the literature by BindingDB 10.1021/jm030233b 10.7270/Q2B27SJR 13678408 aid1797261 Parlow, JJ; Stevens, AM; Stegeman, RA; Stallings, WC; Kurumbail, RG; South, MS Pharmacia Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14601&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10905809 46514935 CHEMBL125585 ZINC13527442 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26716 CC(C)=Nc1cc(O)c(-c2ccccc2)c(CC(=O)NCc2ccc(cc2)C(N)=N)c1O InChI=1S/C25H26N4O3/c1-15(2)29-20-13-21(30)23(17-6-4-3-5-7-17)19(24(20)32)12-22(31)28-14-16-8-10-18(11-9-16)25(26)27/h3-11,13,30,32H,12,14H2,1-2H3,(H3,26,27)(H,28,31) UBOBFGTVNNSBJS-UHFFFAOYSA-N 14602 Benzoquinone Analog 54::N-[(4-carbamimidoylphenyl)methyl]-2-[3,6-dioxo-2-phenyl-5-(propan-2-ylamino)cyclohexa-1,4-dien-1-yl]acetamide Coagulation factor X Homo sapiens >30000 8 22.00 C Curated from the literature by BindingDB 10.1021/jm030233b 10.7270/Q2B27SJR 13678408 aid1797261 Parlow, JJ; Stevens, AM; Stegeman, RA; Stallings, WC; Kurumbail, RG; South, MS Pharmacia Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14602&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91439150 46514936 ZINC14956037 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26718 NC(=N)c1ccc(CNC(=O)Cc2c(F)ccc(NS(=O)(=O)Cc3ccccc3)c2F)cc1 InChI=1S/C23H22F2N4O3S/c24-19-10-11-20(29-33(31,32)14-16-4-2-1-3-5-16)22(25)18(19)12-21(30)28-13-15-6-8-17(9-7-15)23(26)27/h1-11,29H,12-14H2,(H3,26,27)(H,28,30) DLWCGMXCEMSQPE-UHFFFAOYSA-N 14603 N-[(4-carbamimidoylphenyl)methyl]-2-[2,6-difluoro-3-(phenylmethanesulfonamido)phenyl]acetamide::N-{4-[Amino(imino)methyl]benzyl}-2-{3-[(benzylsulfonyl)amino]-2,6-difluorophenyl}acetamide::Substituted Benzene Analog 29b Coagulation factor X Homo sapiens >30000 8 22.00 C Curated from the literature by BindingDB 10.1021/jm030233b 10.7270/Q2B27SJR 13678408 aid1797261 Parlow, JJ; Stevens, AM; Stegeman, RA; Stallings, WC; Kurumbail, RG; South, MS Pharmacia Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14603&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11027118 46514937 ZINC13527400 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 26846 CCOc1cc(OCC)c(F)c(c1)[C@@H](Nc1ccc(C(N)=N)c(O)c1)C(=O)NS(=O)(=O)c1cccc(N)c1 InChI=1S/C25H28FN5O6S/c1-3-36-16-12-19(22(26)21(13-16)37-4-2)23(30-15-8-9-18(24(28)29)20(32)11-15)25(33)31-38(34,35)17-7-5-6-14(27)10-17/h5-13,23,30,32H,3-4,27H2,1-2H3,(H3,28,29)(H,31,33)/t23-/m1/s1 MLPXCKVDBGAVRJ-HSZRJFAPSA-N 14714 (2R)-N-[(3-aminobenzene)sulfonyl]-2-[(4-carbamimidoyl-3-hydroxyphenyl)amino]-2-(3,5-diethoxy-2-fluorophenyl)acetamide::G17905::R-4-[2-(3-aminobenzenesulfonylamino)-1-(3,5-diethoxy-2-fluorophenyl)-2-oxoethylamino]-2-hydroxy-benzamidine.TFA Coagulation factor X Homo sapiens >3500 7.8 22.00 C Curated from the literature by BindingDB 10.1074/jbc.M409068200 10.7270/Q2JM27W3 15632123 aid1797275 Olivero, AG; Eigenbrot, C; Goldsmith, R; Robarge, K; Artis, DR; Flygare, J; Rawson, T; Sutherlin, DP; Kadkhodayan, S; Beresini, M; Elliott, LO; DeGuzman, GG; Banner, DW; Ultsch, M; Marzec, U; Hanson, SR; Refino, C; Bunting, S; Kirchhofer, D Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14714&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 905 1YGC 5326937 46515044 ZINC12338906 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31668 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3cc(Cl)ccc3[nH]2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H23ClN4O5S/c1-12(18(25)23-6-8-29-9-7-23)24-5-4-16(19(24)26)22-30(27,28)17-11-13-10-14(20)2-3-15(13)21-17/h2-3,10-12,16,21-22H,4-9H2,1H3/t12-,16-/m0/s1 BHNMMFGOJRIAEZ-LRDDRELGSA-N 12550 5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1H-indole-2-sulfonamide::Arylsulfonamide 3b::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1s Coagulation factor X Homo sapiens 90 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12550&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GSQ 2J2U 9549257 46513009 DB07848 ZINC14950104 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31669 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3ccc(Cl)cc3[nH]2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H23ClN4O5S/c1-12(18(25)23-6-8-29-9-7-23)24-5-4-15(19(24)26)22-30(27,28)17-10-13-2-3-14(20)11-16(13)21-17/h2-3,10-12,15,21-22H,4-9H2,1H3/t12-,15-/m0/s1 YMUHEQCMXFHGRO-WFASDCNBSA-N 12551 6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1H-indole-2-sulfonamide::Arylsulfonamide 3a::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1t Coagulation factor X Homo sapiens 170 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12551&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16124763 46513010 ZINC14950107 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31670 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc(o2)-c2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H22ClN3O6S2/c1-12(18(24)22-8-10-28-11-9-22)23-7-6-13(19(23)25)21-31(26,27)17-5-2-14(29-17)15-3-4-16(20)30-15/h2-5,12-13,21H,6-11H2,1H3/t12-,13-/m0/s1 QQFAZJXUVBXEGS-STQMWFEESA-N 17652 5-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]furan-2-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1u Coagulation factor X Homo sapiens 1200 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17652&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16125617 46517814 ZINC14965194 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31671 C[C@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)-c2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C18H21ClN4O5S3/c1-11(17(24)22-6-8-28-9-7-22)23-5-4-12(18(23)25)21-31(26,27)15-10-20-16(30-15)13-2-3-14(19)29-13/h2-3,10-12,21H,4-9H2,1H3/t11-,12-/m0/s1 FXULWDDCWDGINP-RYUDHWBXSA-N 17653 2-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1,3-thiazole-5-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1v Coagulation factor X Homo sapiens 5 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17653&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16124764 46517815 ZINC14965199 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31672 C[C@H](N1CC[C@H](NS(=O)(=O)c2ncc(s2)-c2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C18H21ClN4O5S3/c1-11(16(24)22-6-8-28-9-7-22)23-5-4-12(17(23)25)21-31(26,27)18-20-10-14(30-18)13-2-3-15(19)29-13/h2-3,10-12,21H,4-9H2,1H3/t11-,12-/m0/s1 NOXBNBGHSGDFOF-RYUDHWBXSA-N 17654 5-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1,3-thiazole-2-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1w Coagulation factor X Homo sapiens 2 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17654&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16125671 46517816 ZINC14965204 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31673 C[C@H](N1CC[C@H](NS(=O)(=O)c2nnc([nH]2)-c2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C17H21ClN6O5S2/c1-10(15(25)23-6-8-29-9-7-23)24-5-4-11(16(24)26)22-31(27,28)17-19-14(20-21-17)12-2-3-13(18)30-12/h2-3,10-11,22H,4-9H2,1H3,(H,19,20,21)/t10-,11-/m0/s1 FKCQUVAGEOSYRU-QWRGUYRKSA-N 17655 5-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-4H-1,2,4-triazole-3-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1x Coagulation factor X Homo sapiens 534 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17655&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 2J94 16040261 46517817 ZINC16052224 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31674 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc(nc2)-c2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C20H23ClN4O5S2/c1-13(19(26)24-8-10-30-11-9-24)25-7-6-16(20(25)27)23-32(28,29)14-2-3-15(22-12-14)17-4-5-18(21)31-17/h2-5,12-13,16,23H,6-11H2,1H3/t13-,16-/m0/s1 ZNUDWIGYNVFNNO-BBRMVZONSA-N 17656 6-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]pyridine-3-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1y Coagulation factor X Homo sapiens 24 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17656&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16125672 46517818 ZINC14965214 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31030 Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(Cl)cc1 InChI=1S/C23H16Cl2N2O2S/c1-13-6-11-18(17(12-13)22(28)26-15-9-7-14(24)8-10-15)27-23(29)21-20(25)16-4-2-3-5-19(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29) CEOMZCJNXHJBMK-UHFFFAOYSA-N 17226 3-chloro-N-{2-[(4-chlorophenyl)carbamoyl]-4-methylphenyl}-1-benzothiophene-2-carboxamide::benzothiophene compound, 2 Coagulation factor X Homo sapiens 0.33 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17226&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10411684 46517406 ZINC03941009 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31031 Clc1c(sc2ccccc12)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C22H13Cl3N2O2S/c23-12-5-8-14(9-6-12)26-21(28)16-11-13(24)7-10-17(16)27-22(29)20-19(25)15-3-1-2-4-18(15)30-20/h1-11H,(H,26,28)(H,27,29) BPVWZPRUIFGZGN-UHFFFAOYSA-N 17227 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-1-benzothiophene-2-carboxamide::benzothiophene compound, 4 Coagulation factor X Homo sapiens 0.6 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17227&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10073666 46517407 ZINC13487481 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31032 Cc1c(sc2ccccc12)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C23H16Cl2N2O2S/c1-13-17-4-2-3-5-20(17)30-21(13)23(29)27-19-11-8-15(25)12-18(19)22(28)26-16-9-6-14(24)7-10-16/h2-12H,1H3,(H,26,28)(H,27,29) PMROMFBTYNBPHW-UHFFFAOYSA-N 17228 N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-3-methyl-1-benzothiophene-2-carboxamide::benzothiophene compound, 5 Coagulation factor X Homo sapiens 0.82 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17228&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18377048 46517408 ZINC14963617 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31033 Cc1cccc2sc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cc3)c(Cl)c12 InChI=1S/C23H15Cl3N2O2S/c1-12-3-2-4-18-19(12)20(26)21(31-18)23(30)28-17-10-7-14(25)11-16(17)22(29)27-15-8-5-13(24)6-9-15/h2-11H,1H3,(H,27,29)(H,28,30) DTZWTHQTRJTLDO-UHFFFAOYSA-N 17229 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-methyl-1-benzothiophene-2-carboxamide::benzothiophene compound, 6 Coagulation factor X Homo sapiens >5000 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17229&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647676 46517409 ZINC14963621 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31034 Cc1ccc2sc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cc3)c(Cl)c2c1 InChI=1S/C23H15Cl3N2O2S/c1-12-2-9-19-17(10-12)20(26)21(31-19)23(30)28-18-8-5-14(25)11-16(18)22(29)27-15-6-3-13(24)4-7-15/h2-11H,1H3,(H,27,29)(H,28,30) NSOUNEBVSLKCGG-UHFFFAOYSA-N 17230 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-5-methyl-1-benzothiophene-2-carboxamide::Inseparable assay mixture of 5-methyl and 7-methyl compounds::benzothiophene compound, 7 Coagulation factor X Homo sapiens 54 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17230&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647677 46517410 ZINC14963624 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31035 Cc1ccc2c(Cl)c(sc2c1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C23H15Cl3N2O2S/c1-12-2-8-16-19(10-12)31-21(20(16)26)23(30)28-18-9-5-14(25)11-17(18)22(29)27-15-6-3-13(24)4-7-15/h2-11H,1H3,(H,27,29)(H,28,30) YAQJDQSFMATAHT-UHFFFAOYSA-N 17231 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-6-methyl-1-benzothiophene-2-carboxamide::benzothiophene compound, 8 Coagulation factor X Homo sapiens 0.95 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17231&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376901 46517411 ZINC14963628 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31036 CN(C)Cc1c(sc2ccccc12)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C25H21Cl2N3O2S/c1-30(2)14-20-18-5-3-4-6-22(18)33-23(20)25(32)29-21-12-9-16(27)13-19(21)24(31)28-17-10-7-15(26)8-11-17/h3-13H,14H2,1-2H3,(H,28,31)(H,29,32) GUWHVNCCIYIYIP-UHFFFAOYSA-N 17232 N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-3-[(dimethylamino)methyl]-1-benzothiophene-2-carboxamide::benzothiophene compound, 11 Coagulation factor X Homo sapiens 9.0 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17232&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10481025 46517412 ZINC14963631 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31037 CN(C)Cc1ccc2c(Cl)c(sc2c1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C25H20Cl3N3O2S/c1-31(2)13-14-3-9-18-21(11-14)34-23(22(18)28)25(33)30-20-10-6-16(27)12-19(20)24(32)29-17-7-4-15(26)5-8-17/h3-12H,13H2,1-2H3,(H,29,32)(H,30,33) MQKQSGLRSREOQS-UHFFFAOYSA-N 17233 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-6-[(dimethylamino)methyl]-1-benzothiophene-2-carboxamide::benzothiophene compound, 12 Coagulation factor X Homo sapiens 14 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17233&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376959 46517413 ZINC14963636 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31038 CN1CCN(Cc2c(sc3ccccc23)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)CC1 InChI=1S/C28H26Cl2N4O2S/c1-33-12-14-34(15-13-33)17-23-21-4-2-3-5-25(21)37-26(23)28(36)32-24-11-8-19(30)16-22(24)27(35)31-20-9-6-18(29)7-10-20/h2-11,16H,12-15,17H2,1H3,(H,31,35)(H,32,36) VCMKFROKSDQHLO-UHFFFAOYSA-N 17234 N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-3-[(4-methylpiperazin-1-yl)methyl]-1-benzothiophene-2-carboxamide::benzothiophene compound, 13 Coagulation factor X Homo sapiens 20 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17234&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18377002 46517414 ZINC23359279 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31039 CN1CCN(Cc2ccc3c(Cl)c(sc3c2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)CC1 InChI=1S/C28H25Cl3N4O2S/c1-34-10-12-35(13-11-34)16-17-2-8-21-24(14-17)38-26(25(21)31)28(37)33-23-9-5-19(30)15-22(23)27(36)32-20-6-3-18(29)4-7-20/h2-9,14-15H,10-13,16H2,1H3,(H,32,36)(H,33,37) PHYGKMMNCNPGMU-UHFFFAOYSA-N 17235 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-6-[(4-methylpiperazin-1-yl)methyl]-1-benzothiophene-2-carboxamide::benzothiophene compound, 14 Coagulation factor X Homo sapiens 21 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17235&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376891 46517415 ZINC23359282 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31040 OC(=O)CN1CCN(Cc2ccc3c(Cl)c(sc3c2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)CC1 InChI=1S/C29H25Cl3N4O4S/c30-18-2-5-20(6-3-18)33-28(39)22-14-19(31)4-8-23(22)34-29(40)27-26(32)21-7-1-17(13-24(21)41-27)15-35-9-11-36(12-10-35)16-25(37)38/h1-8,13-14H,9-12,15-16H2,(H,33,39)(H,34,40)(H,37,38) HJYCQWMDGTUWII-UHFFFAOYSA-N 17236 2-(4-{[3-chloro-2-({4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}carbamoyl)-1-benzothiophen-6-yl]methyl}piperazin-1-yl)acetic acid::benzothiophene compound, 16 Coagulation factor X Homo sapiens 9.5 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17236&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376826 46517416 ZINC28713115 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31041 Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C19H13Cl3N2O2S/c1-10-9-27-17(16(10)22)19(26)24-15-7-4-12(21)8-14(15)18(25)23-13-5-2-11(20)3-6-13/h2-9H,1H3,(H,23,25)(H,24,26) YXKVUHJYIPCGRM-UHFFFAOYSA-N 17237 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-methylthiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 20 Coagulation factor X Homo sapiens 18 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17237&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18377010 46517417 ZINC14963648 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31042 Cc1cc(Cl)c(s1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C19H13Cl3N2O2S/c1-10-8-15(22)17(27-10)19(26)24-16-7-4-12(21)9-14(16)18(25)23-13-5-2-11(20)3-6-13/h2-9H,1H3,(H,23,25)(H,24,26) BQBNVFZMPTVXJE-UHFFFAOYSA-N 17238 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-5-methylthiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 24 Coagulation factor X Homo sapiens 24 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17238&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376748 46517418 ZINC14963652 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31043 CN1CCN(Cc2csc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cc3)c2Cl)CC1 InChI=1S/C24H23Cl3N4O2S/c1-30-8-10-31(11-9-30)13-15-14-34-22(21(15)27)24(33)29-20-7-4-17(26)12-19(20)23(32)28-18-5-2-16(25)3-6-18/h2-7,12,14H,8-11,13H2,1H3,(H,28,32)(H,29,33) FIZKTFMGWNHPMZ-UHFFFAOYSA-N 17085 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-[(4-methylpiperazin-1-yl)methyl]thiophene-2-carboxamide::Thiophene-Anthranilamide, 2::thiophene-containing non-amidine inhibitor, 31 Coagulation factor X Homo sapiens 1 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17085&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search XLC 1MQ5 447193 46517315 ZINC21289563 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31044 CN1CCN(Cc2cc(Cl)c(s2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)CC1 InChI=1S/C24H23Cl3N4O2S/c1-30-8-10-31(11-9-30)14-18-13-20(27)22(34-18)24(33)29-21-7-4-16(26)12-19(21)23(32)28-17-5-2-15(25)3-6-17/h2-7,12-13H,8-11,14H2,1H3,(H,28,32)(H,29,33) RAJDVLCJFXQAIS-UHFFFAOYSA-N 17239 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-5-[(4-methylpiperazin-1-yl)methyl]thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 32 Coagulation factor X Homo sapiens 5.6 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17239&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376888 46517419 ZINC23359284 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31045 Clc1c(CN2CCOCC2)csc1C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C23H20Cl3N3O3S/c24-15-1-4-17(5-2-15)27-22(30)18-11-16(25)3-6-19(18)28-23(31)21-20(26)14(13-33-21)12-29-7-9-32-10-8-29/h1-6,11,13H,7-10,12H2,(H,27,30)(H,28,31) RBGVIOAFMJAATH-UHFFFAOYSA-N 17240 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-(morpholin-4-ylmethyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 33 Coagulation factor X Homo sapiens 6.2 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17240&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376562 46517420 ZINC14963660 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31046 Clc1cc(CN2CCOCC2)sc1C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C23H20Cl3N3O3S/c24-14-1-4-16(5-2-14)27-22(30)18-11-15(25)3-6-20(18)28-23(31)21-19(26)12-17(33-21)13-29-7-9-32-10-8-29/h1-6,11-12H,7-10,13H2,(H,27,30)(H,28,31) QOHWJHLSEMXCMA-UHFFFAOYSA-N 17241 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-5-(morpholin-4-ylmethyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 34 Coagulation factor X Homo sapiens 34 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17241&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376625 46517421 ZINC14963664 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31047 Clc1c(Cn2ccnc2)csc1C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C22H15Cl3N4O2S/c23-14-1-4-16(5-2-14)27-21(30)17-9-15(24)3-6-18(17)28-22(31)20-19(25)13(11-32-20)10-29-8-7-26-12-29/h1-9,11-12H,10H2,(H,27,30)(H,28,31) URIZEPZRDZSTNX-UHFFFAOYSA-N 17242 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-(1H-imidazol-1-ylmethyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 35 Coagulation factor X Homo sapiens 1.9 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17242&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376618 46517422 ZINC14963668 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31048 Clc1cc(Cn2ccnc2)sc1C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C22H15Cl3N4O2S/c23-13-1-4-15(5-2-13)27-21(30)17-9-14(24)3-6-19(17)28-22(31)20-18(25)10-16(32-20)11-29-8-7-26-12-29/h1-10,12H,11H2,(H,27,30)(H,28,31) NYTXQSBCDGIIBX-UHFFFAOYSA-N 17243 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-5-(1H-imidazol-1-ylmethyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 36 Coagulation factor X Homo sapiens 7.2 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17243&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376827 46517423 ZINC14963673 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31049 CN1CCN(Cc2c(C)sc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cc3)c2Cl)CC1 InChI=1S/C25H25Cl3N4O2S/c1-15-20(14-32-11-9-31(2)10-12-32)22(28)23(35-15)25(34)30-21-8-5-17(27)13-19(21)24(33)29-18-6-3-16(26)4-7-18/h3-8,13H,9-12,14H2,1-2H3,(H,29,33)(H,30,34) INKAAAVRNUCZBR-UHFFFAOYSA-N 17244 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-5-methyl-4-[(4-methylpiperazin-1-yl)methyl]thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 40 Coagulation factor X Homo sapiens 12 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17244&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376656 46517424 ZINC23359287 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31050 CN1CCN(Cc2sc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cc3)c(Cl)c2C)CC1 InChI=1S/C25H25Cl3N4O2S/c1-15-21(14-32-11-9-31(2)10-12-32)35-23(22(15)28)25(34)30-20-8-5-17(27)13-19(20)24(33)29-18-6-3-16(26)4-7-18/h3-8,13H,9-12,14H2,1-2H3,(H,29,33)(H,30,34) XNZLOUVGIOARBF-UHFFFAOYSA-N 17245 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-methyl-5-[(4-methylpiperazin-1-yl)methyl]thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 44 Coagulation factor X Homo sapiens 10 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17245&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376605 46517425 ZINC23359290 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31051 CCCNCc1sc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c(Cl)c1CNCCC InChI=1S/C26H29Cl3N4O2S/c1-3-11-30-14-20-22(15-31-12-4-2)36-24(23(20)29)26(35)33-21-10-7-17(28)13-19(21)25(34)32-18-8-5-16(27)6-9-18/h5-10,13,30-31H,3-4,11-12,14-15H2,1-2H3,(H,32,34)(H,33,35) FWTSOYMNLPZPPX-UHFFFAOYSA-N 17246 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4,5-bis[(propylamino)methyl]thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 48 Coagulation factor X Homo sapiens 7.5 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17246&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376919 46517426 ZINC14963685 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31052 CCCN1Cc2sc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cc3)c(Cl)c2C1 InChI=1S/C23H20Cl3N3O2S/c1-2-9-29-11-17-19(12-29)32-21(20(17)26)23(31)28-18-8-5-14(25)10-16(18)22(30)27-15-6-3-13(24)4-7-15/h3-8,10H,2,9,11-12H2,1H3,(H,27,30)(H,28,31) FWEQTRFUWAMPTQ-UHFFFAOYSA-N 17247 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-5-propyl-4H,5H,6H-thieno[2,3-c]pyrrole-2-carboxamide::thiophene-containing non-amidine inhibitor, 49 Coagulation factor X Homo sapiens 2.2 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17247&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647678 46517427 ZINC14963689 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31053 CCN1CCN(Cc2csc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cc3)c2Cl)CC1 InChI=1S/C25H25Cl3N4O2S/c1-2-31-9-11-32(12-10-31)14-16-15-35-23(22(16)28)25(34)30-21-8-5-18(27)13-20(21)24(33)29-19-6-3-17(26)4-7-19/h3-8,13,15H,2,9-12,14H2,1H3,(H,29,33)(H,30,34) URWOFVWFYVNSPO-UHFFFAOYSA-N 17248 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-[(4-ethylpiperazin-1-yl)methyl]thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 50 Coagulation factor X Homo sapiens 1.6 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17248&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376606 46517428 ZINC23359298 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31054 CC(=O)N1CCN(Cc2csc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cc3)c2Cl)CC1 InChI=1S/C25H23Cl3N4O3S/c1-15(33)32-10-8-31(9-11-32)13-16-14-36-23(22(16)28)25(35)30-21-7-4-18(27)12-20(21)24(34)29-19-5-2-17(26)3-6-19/h2-7,12,14H,8-11,13H2,1H3,(H,29,34)(H,30,35) PRXYXBVCYQVJNW-UHFFFAOYSA-N 17249 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-[(4-acetylpiperazin-1-yl)methyl]thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 51 Coagulation factor X Homo sapiens 6.0 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17249&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376659 46517429 ZINC14963697 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31055 Clc1c(CN2CCSCC2)csc1C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C23H20Cl3N3O2S2/c24-15-1-4-17(5-2-15)27-22(30)18-11-16(25)3-6-19(18)28-23(31)21-20(26)14(13-33-21)12-29-7-9-32-10-8-29/h1-6,11,13H,7-10,12H2,(H,27,30)(H,28,31) KHLOTGYYBBYMIA-UHFFFAOYSA-N 17250 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-(thiomorpholin-4-ylmethyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 52 Coagulation factor X Homo sapiens 4.8 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17250&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376780 46517430 ZINC14963702 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31056 CCOC(=O)CN(C)Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C24H22Cl3N3O4S/c1-3-34-20(31)12-30(2)11-14-13-35-22(21(14)27)24(33)29-19-9-6-16(26)10-18(19)23(32)28-17-7-4-15(25)5-8-17/h4-10,13H,3,11-12H2,1-2H3,(H,28,32)(H,29,33) UPQXHLVWWXCGHX-UHFFFAOYSA-N 17251 ethyl 2-({[4-chloro-5-({4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}carbamoyl)thiophen-3-yl]methyl}(methyl)amino)acetate::thiophene-containing non-amidine inhibitor, 53 Coagulation factor X Homo sapiens 5.2 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17251&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376939 46517431 ZINC14963706 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31057 CN(CCO)Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C22H20Cl3N3O3S/c1-28(8-9-29)11-13-12-32-20(19(13)25)22(31)27-18-7-4-15(24)10-17(18)21(30)26-16-5-2-14(23)3-6-16/h2-7,10,12,29H,8-9,11H2,1H3,(H,26,30)(H,27,31) QNIUXBDPJGNTPV-UHFFFAOYSA-N 17252 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-{[(2-hydroxyethyl)(methyl)amino]methyl}thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 54 Coagulation factor X Homo sapiens 0.8 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17252&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376669 46517432 ZINC14963710 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31058 CN(CC(O)CO)Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C23H22Cl3N3O4S/c1-29(10-17(31)11-30)9-13-12-34-21(20(13)26)23(33)28-19-7-4-15(25)8-18(19)22(32)27-16-5-2-14(24)3-6-16/h2-8,12,17,30-31H,9-11H2,1H3,(H,27,32)(H,28,33) FLTXDVPKENYNGT-UHFFFAOYSA-N 17253 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-{[(2,3-dihydroxypropyl)(methyl)amino]methyl}thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 55 Coagulation factor X Homo sapiens 1.4 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17253&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376880 46517433 ZINC14963718 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31059 OCCOCCNCc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C23H22Cl3N3O4S/c24-15-1-4-17(5-2-15)28-22(31)18-11-16(25)3-6-19(18)29-23(32)21-20(26)14(13-34-21)12-27-7-9-33-10-8-30/h1-6,11,13,27,30H,7-10,12H2,(H,28,31)(H,29,32) UXFYQNNDCOYLRK-UHFFFAOYSA-N 17254 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-({[2-(2-hydroxyethoxy)ethyl]amino}methyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 56 Coagulation factor X Homo sapiens 3.4 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17254&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647679 46517434 ZINC14963722 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31060 CN(CCOCCO)Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C24H24Cl3N3O4S/c1-30(8-10-34-11-9-31)13-15-14-35-22(21(15)27)24(33)29-20-7-4-17(26)12-19(20)23(32)28-18-5-2-16(25)3-6-18/h2-7,12,14,31H,8-11,13H2,1H3,(H,28,32)(H,29,33) NBZNHZFHLOUBNK-UHFFFAOYSA-N 17255 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-({[2-(2-hydroxyethoxy)ethyl](methyl)amino}methyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 57 Coagulation factor X Homo sapiens 1.5 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17255&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647680 46517435 ZINC14963725 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31061 CN(C)CCN(C)Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C24H25Cl3N4O2S/c1-30(2)10-11-31(3)13-15-14-34-22(21(15)27)24(33)29-20-9-6-17(26)12-19(20)23(32)28-18-7-4-16(25)5-8-18/h4-9,12,14H,10-11,13H2,1-3H3,(H,28,32)(H,29,33) QDKKSLVXVLBPRN-UHFFFAOYSA-N 17256 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-({[2-(dimethylamino)ethyl](methyl)amino}methyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 58 Coagulation factor X Homo sapiens 0.45 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17256&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376832 46517436 ZINC23359301 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31062 CCN(CC)CCN(C)Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C26H29Cl3N4O2S/c1-4-33(5-2)13-12-32(3)15-17-16-36-24(23(17)29)26(35)31-22-11-8-19(28)14-21(22)25(34)30-20-9-6-18(27)7-10-20/h6-11,14,16H,4-5,12-13,15H2,1-3H3,(H,30,34)(H,31,35) YPBQWYRTPLXSAK-UHFFFAOYSA-N 17257 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-({[2-(diethylamino)ethyl](methyl)amino}methyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 59 Coagulation factor X Homo sapiens 0.52 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17257&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376719 46517437 ZINC23359304 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31063 CN(C)CCCN(C)Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C25H27Cl3N4O2S/c1-31(2)11-4-12-32(3)14-16-15-35-23(22(16)28)25(34)30-21-10-7-18(27)13-20(21)24(33)29-19-8-5-17(26)6-9-19/h5-10,13,15H,4,11-12,14H2,1-3H3,(H,29,33)(H,30,34) FWUDCJIXDFNQNS-UHFFFAOYSA-N 17258 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-({[3-(dimethylamino)propyl](methyl)amino}methyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 60 Coagulation factor X Homo sapiens 0.60 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17258&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376642 46517438 ZINC14963738 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31064 CN(CCN1CCCC1)Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C26H27Cl3N4O2S/c1-32(12-13-33-10-2-3-11-33)15-17-16-36-24(23(17)29)26(35)31-22-9-6-19(28)14-21(22)25(34)30-20-7-4-18(27)5-8-20/h4-9,14,16H,2-3,10-13,15H2,1H3,(H,30,34)(H,31,35) FNZSBRAEFDXJOS-UHFFFAOYSA-N 17259 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-({methyl[2-(pyrrolidin-1-yl)ethyl]amino}methyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 61 Coagulation factor X Homo sapiens 0.3 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17259&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376973 46517439 ZINC23359307 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31065 Clc1c(CNCCCn2ccnc2)csc1C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C25H22Cl3N5O2S/c26-17-2-5-19(6-3-17)31-24(34)20-12-18(27)4-7-21(20)32-25(35)23-22(28)16(14-36-23)13-29-8-1-10-33-11-9-30-15-33/h2-7,9,11-12,14-15,29H,1,8,10,13H2,(H,31,34)(H,32,35) SGUFDEKHCMVEHV-UHFFFAOYSA-N 17260 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-({[3-(1H-imidazol-1-yl)propyl]amino}methyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 62 Coagulation factor X Homo sapiens 4.6 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17260&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376921 46517440 ZINC14963746 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31066 CN(Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl)C1CCN(C)CC1 InChI=1S/C26H27Cl3N4O2S/c1-32-11-9-20(10-12-32)33(2)14-16-15-36-24(23(16)29)26(35)31-22-8-5-18(28)13-21(22)25(34)30-19-6-3-17(27)4-7-19/h3-8,13,15,20H,9-12,14H2,1-2H3,(H,30,34)(H,31,35) IFLAFCATJQGCIF-UHFFFAOYSA-N 17261 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-{[methyl(1-methylpiperidin-4-yl)amino]methyl}thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 63 Coagulation factor X Homo sapiens 0.38 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17261&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376905 46517441 ZINC14963750 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31067 Clc1c(Cn2cccn2)csc1C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C22H15Cl3N4O2S/c23-14-2-5-16(6-3-14)27-21(30)17-10-15(24)4-7-18(17)28-22(31)20-19(25)13(12-32-20)11-29-9-1-8-26-29/h1-10,12H,11H2,(H,27,30)(H,28,31) NYUCYTUIRJYMRW-UHFFFAOYSA-N 17262 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-(1H-pyrazol-1-ylmethyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 64 Coagulation factor X Homo sapiens 2.1 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17262&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376843 46517442 ZINC14963755 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31068 Clc1c(Cn2cncn2)csc1C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C21H14Cl3N5O2S/c22-13-1-4-15(5-2-13)27-20(30)16-7-14(23)3-6-17(16)28-21(31)19-18(24)12(9-32-19)8-29-11-25-10-26-29/h1-7,9-11H,8H2,(H,27,30)(H,28,31) AYGOWKYTIJMKLX-UHFFFAOYSA-N 17263 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-(1H-1,2,4-triazol-1-ylmethyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 65 Coagulation factor X Homo sapiens 1.6 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17263&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376976 46517443 ZINC14963759 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31069 Clc1c(Cn2ccnn2)csc1C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C21H14Cl3N5O2S/c22-13-1-4-15(5-2-13)26-20(30)16-9-14(23)3-6-17(16)27-21(31)19-18(24)12(11-32-19)10-29-8-7-25-28-29/h1-9,11H,10H2,(H,26,30)(H,27,31) SGFUHAVCRILDAM-UHFFFAOYSA-N 17264 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-(1H-1,2,3-triazol-1-ylmethyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 66 Coagulation factor X Homo sapiens 1.4 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17264&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376882 46517444 ZINC14963763 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31070 Clc1c(Cn2nccn2)csc1C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C21H14Cl3N5O2S/c22-13-1-4-15(5-2-13)27-20(30)16-9-14(23)3-6-17(16)28-21(31)19-18(24)12(11-32-19)10-29-25-7-8-26-29/h1-9,11H,10H2,(H,27,30)(H,28,31) WKQORDONQMBRAN-UHFFFAOYSA-N 17265 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-(2H-1,2,3-triazol-2-ylmethyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 67 Coagulation factor X Homo sapiens 3.5 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17265&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376714 46509538 ZINC14963767 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31071 Clc1c(Cn2cnnn2)csc1C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C20H13Cl3N6O2S/c21-12-1-4-14(5-2-12)25-19(30)15-7-13(22)3-6-16(15)26-20(31)18-17(23)11(9-32-18)8-29-10-24-27-28-29/h1-7,9-10H,8H2,(H,25,30)(H,26,31) XAUOSNVKTOUKQA-UHFFFAOYSA-N 17266 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-(1H-1,2,3,4-tetrazol-1-ylmethyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 68 Coagulation factor X Homo sapiens 1.7 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17266&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18377003 46517445 ZINC14963771 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31072 Clc1c(Cn2ncnn2)csc1C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1 InChI=1S/C20H13Cl3N6O2S/c21-12-1-4-14(5-2-12)26-19(30)15-7-13(22)3-6-16(15)27-20(31)18-17(23)11(9-32-18)8-29-25-10-24-28-29/h1-7,9-10H,8H2,(H,26,30)(H,27,31) UJXMNNKAKLLGON-UHFFFAOYSA-N 17267 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-(2H-1,2,3,4-tetrazol-2-ylmethyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 69 Coagulation factor X Homo sapiens 2.0 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17267&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376696 46517446 ZINC14963775 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31073 CSCc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C20H15Cl3N2O2S2/c1-28-9-11-10-29-18(17(11)23)20(27)25-16-7-4-13(22)8-15(16)19(26)24-14-5-2-12(21)3-6-14/h2-8,10H,9H2,1H3,(H,24,26)(H,25,27) HJPGTJZRQOHFSA-UHFFFAOYSA-N 17268 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-[(methylsulfanyl)methyl]thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 70 Coagulation factor X Homo sapiens 0.8 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17268&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376839 46517447 ZINC14963780 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31074 CS(=O)Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C20H15Cl3N2O3S2/c1-30(28)10-11-9-29-18(17(11)23)20(27)25-16-7-4-13(22)8-15(16)19(26)24-14-5-2-12(21)3-6-14/h2-9H,10H2,1H3,(H,24,26)(H,25,27) ZVZCIGHYDQHRNA-UHFFFAOYSA-N 17269 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-(methanesulfinylmethyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 71 Coagulation factor X Homo sapiens 0.4 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17269&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10028986 46517448 ZINC14963788 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31075 CS(=O)(=O)Cc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C20H15Cl3N2O4S2/c1-31(28,29)10-11-9-30-18(17(11)23)20(27)25-16-7-4-13(22)8-15(16)19(26)24-14-5-2-12(21)3-6-14/h2-9H,10H2,1H3,(H,24,26)(H,25,27) ZOHDIPRPSVMPAE-UHFFFAOYSA-N 17270 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-(methanesulfonylmethyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 72 Coagulation factor X Homo sapiens 2.1 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17270&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376871 46517449 ZINC14963792 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31076 CN(C)CCSCc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C23H22Cl3N3O2S2/c1-29(2)9-10-32-12-14-13-33-21(20(14)26)23(31)28-19-8-5-16(25)11-18(19)22(30)27-17-6-3-15(24)4-7-17/h3-8,11,13H,9-10,12H2,1-2H3,(H,27,30)(H,28,31) STGQYQZIWLRALS-UHFFFAOYSA-N 17271 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-({[2-(dimethylamino)ethyl]sulfanyl}methyl)thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 73 Coagulation factor X Homo sapiens 2.7 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17271&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376930 46517450 ZINC14963796 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31077 COCCOCc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C22H19Cl3N2O4S/c1-30-8-9-31-11-13-12-32-20(19(13)25)22(29)27-18-7-4-15(24)10-17(18)21(28)26-16-5-2-14(23)3-6-16/h2-7,10,12H,8-9,11H2,1H3,(H,26,28)(H,27,29) GAIANRODMUVKOQ-UHFFFAOYSA-N 17272 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-[(2-methoxyethoxy)methyl]thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 74 Coagulation factor X Homo sapiens 12 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17272&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376679 46517451 ZINC14963800 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31078 COCCOCCOCc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C24H23Cl3N2O5S/c1-32-8-9-33-10-11-34-13-15-14-35-22(21(15)27)24(31)29-20-7-4-17(26)12-19(20)23(30)28-18-5-2-16(25)3-6-18/h2-7,12,14H,8-11,13H2,1H3,(H,28,30)(H,29,31) OWASSQDGIGRWRL-UHFFFAOYSA-N 17273 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-{[2-(2-methoxyethoxy)ethoxy]methyl}thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 75 Coagulation factor X Homo sapiens 10 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17273&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18376663 46517452 ZINC14963804 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31079 CC1(C)OCC(COCc2csc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cc3)c2Cl)O1 InChI=1S/C25H23Cl3N2O5S/c1-25(2)34-12-18(35-25)11-33-10-14-13-36-22(21(14)28)24(32)30-20-8-5-16(27)9-19(20)23(31)29-17-6-3-15(26)4-7-17/h3-9,13,18H,10-12H2,1-2H3,(H,29,31)(H,30,32) YZZCILQJYSWGRF-UHFFFAOYSA-N 17274 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-{[(2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]methyl}thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 76 Coagulation factor X Homo sapiens 20 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17274&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647681 46517453 ZINC14963813 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31080 OCC(O)COCc1csc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)c1Cl InChI=1S/C22H19Cl3N2O5S/c23-13-1-4-15(5-2-13)26-21(30)17-7-14(24)3-6-18(17)27-22(31)20-19(25)12(11-33-20)9-32-10-16(29)8-28/h1-7,11,16,28-29H,8-10H2,(H,26,30)(H,27,31) FLEZEQUDLQLWHA-UHFFFAOYSA-N 17275 3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]phenyl}-4-[(2,3-dihydroxypropoxy)methyl]thiophene-2-carboxamide::thiophene-containing non-amidine inhibitor, 77 Coagulation factor X Homo sapiens 5.7 Curated from the literature by BindingDB 10.1016/j.bmc.2006.12.019 10.7270/Q2MS3R1T 17227710 aid1797602 Kochanny, MJ; Adler, M; Ewing, J; Griedel, BD; Ho, E; Karanjawala, R; Lee, W; Lentz, D; Liang, AM; Morrissey, MM; Phillips, GB; Post, J; Sacchi, KL; Sakata, ST; Subramanyam, B; Vergona, R; Walters, J; White, KA; Whitlow, M; Ye, B; Zhao, Z; Shaw, KJ Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17275&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23647682 46517454 ZINC14963823 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31171 NC(=N)c1ccc(\C=C2\CCCC\C(=C\c3ccc(cc3)C(N)=N)C2=O)cc1 InChI=1S/C23H24N4O/c24-22(25)17-9-5-15(6-10-17)13-19-3-1-2-4-20(21(19)28)14-16-7-11-18(12-8-16)23(26)27/h5-14H,1-4H2,(H3,24,25)(H3,26,27)/b19-13-,20-14- BGRKMKHJBDYTGS-AXPXABNXSA-N 17277 (Z,Z)BABCH::4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl)methylidene]-2-oxocycloheptylidene]methyl}benzene-1-carboximidamide::CHEMBL55035 Coagulation factor X Homo sapiens 0.66 7.5 22.00 C Curated from the literature by BindingDB 10.1107/s0907444999007350 10.7270/Q2H1308B 10417407 aid1797608 Whitlow, M; Arnaiz, DO; Buckman, BO; Davey, DD; Griedel, B; Guilford, WJ; Koovakkat, SK; Liang, A; Mohan, R; Phillips, GB; Seto, M; Shaw, KJ; Xu, W; Zhao, Z; Light, DR; Morrissey, MM Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17277&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1A5H,1V2N 10361934 46517455 CHEMBL55035 ZINC01545718 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31172 Cc1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2cccc(c2)C(N)=N)c1F InChI=1S/C20H17F2N5O2/c1-10-15(21)19(28-13-6-2-4-11(8-13)17(23)24)27-20(16(10)22)29-14-7-3-5-12(9-14)18(25)26/h2-9H,1H3,(H3,23,24)(H3,25,26) ZXIHYCYAQUQHSG-UHFFFAOYSA-N 17278 3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-methylpyridin-2-yl]oxy}benzene-1-carboximidamide::CHEMBL49636::Pyridine template, III::ZK-805623 Coagulation factor X Homo sapiens 14 7.5 22.00 C Curated from the literature by BindingDB 10.1107/s0907444999007350 10.7270/Q2H1308B 10417407 aid1797608 Whitlow, M; Arnaiz, DO; Buckman, BO; Davey, DD; Griedel, B; Guilford, WJ; Koovakkat, SK; Liang, A; Mohan, R; Phillips, GB; Seto, M; Shaw, KJ; Xu, W; Zhao, Z; Light, DR; Morrissey, MM Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17278&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1QB6 448061 46517456 CHEMBL49636 ZINC00585999 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31173 NC(=N)c1ccc(O)c(Oc2cc(cc(Oc3cccc(c3)C3=NCCN3)n2)C(O)=O)c1 InChI=1S/C22H19N5O5/c23-20(24)12-4-5-16(28)17(9-12)32-19-11-14(22(29)30)10-18(27-19)31-15-3-1-2-13(8-15)21-25-6-7-26-21/h1-5,8-11,28H,6-7H2,(H3,23,24)(H,25,26)(H,29,30) KDDSLUYCOZXRQI-UHFFFAOYSA-N 17279 2-(5-carbamimidoyl-2-hydroxyphenoxy)-6-[3-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridine-4-carboxylic acid::CHEMBL315014::Pyridine template, IV::ZK-806688 Coagulation factor X Homo sapiens 85 7.5 22.00 C Curated from the literature by BindingDB 10.1107/s0907444999007350 10.7270/Q2H1308B 10417407 aid1797608 Whitlow, M; Arnaiz, DO; Buckman, BO; Davey, DD; Griedel, B; Guilford, WJ; Koovakkat, SK; Liang, A; Mohan, R; Phillips, GB; Seto, M; Shaw, KJ; Xu, W; Zhao, Z; Light, DR; Morrissey, MM Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17279&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1QBN 10388137 46517457 CHEMBL315014 ZINC12355224 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31174 CN1CCN=C1c1cccc(Oc2nc(Oc3cc(ccc3O)C(N)=N)c(F)c(N3CCCC(C3)C(O)=O)c2F)c1 InChI=1S/C28H28F2N6O5/c1-35-11-9-33-25(35)16-4-2-6-18(12-16)40-26-21(29)23(36-10-3-5-17(14-36)28(38)39)22(30)27(34-26)41-20-13-15(24(31)32)7-8-19(20)37/h2,4,6-8,12-13,17,37H,3,5,9-11,14H2,1H3,(H3,31,32)(H,38,39) NRCRZGGGYMSXER-UHFFFAOYSA-N 17280 1-[2-(5-carbamimidoyl-2-hydroxyphenoxy)-3,5-difluoro-6-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]piperidine-3-carboxylic acid::Pyridine template, V Coagulation factor X Homo sapiens 0.11 7.5 22.00 C Curated from the literature by BindingDB 10.1107/s0907444999007350 10.7270/Q2H1308B 10417407 aid1797608 Whitlow, M; Arnaiz, DO; Buckman, BO; Davey, DD; Griedel, B; Guilford, WJ; Koovakkat, SK; Liang, A; Mohan, R; Phillips, GB; Seto, M; Shaw, KJ; Xu, W; Zhao, Z; Light, DR; Morrissey, MM Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17280&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1QB1 23441831 46517458 ZINC70690459 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31175 CC(=N)N1CCC(CC1)Oc1ccc2c(c1)n(Cc1ccc3ccc(cc3c1)C(N)=N)c1ccccc21 InChI=1S/C31H31N5O/c1-20(32)35-14-12-25(13-15-35)37-26-10-11-28-27-4-2-3-5-29(27)36(30(28)18-26)19-21-6-7-22-8-9-23(31(33)34)17-24(22)16-21/h2-11,16-18,25,32H,12-15,19H2,1H3,(H3,33,34) DZLGSWPXZYDHBD-UHFFFAOYSA-N 17281 7-({2-[(1-ethanimidoylpiperidin-4-yl)oxy]-9H-carbazol-9-yl}methyl)naphthalene-2-carboximidamide::CHEMBL369251::Naphthylamidine template, II::ZK-806450 Coagulation factor X Homo sapiens 1.6 7.5 22.00 C Curated from the literature by BindingDB 10.1107/s0907444999007350 10.7270/Q2H1308B 10417407 aid1797608 Whitlow, M; Arnaiz, DO; Buckman, BO; Davey, DD; Griedel, B; Guilford, WJ; Koovakkat, SK; Liang, A; Mohan, R; Phillips, GB; Seto, M; Shaw, KJ; Xu, W; Zhao, Z; Light, DR; Morrissey, MM Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17281&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 806 1QB9 448062 46517459 CHEMBL369251 DB02112 ZINC09998610 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31176 CC(=N)N1CCC(CC1)Oc1ccc2nc(C)n(Cc3ccc4ccc(cc4c3)C(N)=N)c2c1 InChI=1S/C27H30N6O/c1-17(28)32-11-9-23(10-12-32)34-24-7-8-25-26(15-24)33(18(2)31-25)16-19-3-4-20-5-6-21(27(29)30)14-22(20)13-19/h3-8,13-15,23,28H,9-12,16H2,1-2H3,(H3,29,30) JABMRQOJSAZJAD-UHFFFAOYSA-N 17282 7-({6-[(1-ethanimidoylpiperidin-4-yl)oxy]-2-methyl-1H-1,3-benzodiazol-1-yl}methyl)naphthalene-2-carboximidamide::CHEMBL173020::Naphthylamidine template, I::ZK-806711 Coagulation factor X Homo sapiens 0.27 7.5 22.00 C Curated from the literature by BindingDB 10.1107/s0907444999007350 10.7270/Q2H1308B 10417407 aid1797608 Whitlow, M; Arnaiz, DO; Buckman, BO; Davey, DD; Griedel, B; Guilford, WJ; Koovakkat, SK; Liang, A; Mohan, R; Phillips, GB; Seto, M; Shaw, KJ; Xu, W; Zhao, Z; Light, DR; Morrissey, MM Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17282&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1QBO 448065 46517460 CHEMBL173020 ZINC09998611 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31177 CC(=N)N1CC[C@@H](C1)Oc1ccc(cc1)[C@H](Cc1ccc2ccc(cc2c1)C(N)=N)C(O)=O InChI=1S/C26H28N4O3/c1-16(27)30-11-10-23(15-30)33-22-8-6-19(7-9-22)24(26(31)32)13-17-2-3-18-4-5-20(25(28)29)14-21(18)12-17/h2-9,12,14,23-24,27H,10-11,13,15H2,1H3,(H3,28,29)(H,31,32)/t23-,24-/m0/s1 AGRCGQSFFMCBRE-ZEQRLZLVSA-N 17283 (2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-{[(3S)-1-ethanimidoylpyrrolidin-3-yl]oxy}phenyl)propanoic acid::CHEMBL19902::DX-9065a Coagulation factor X Homo sapiens 20 7.5 22.00 C Curated from the literature by BindingDB 10.1107/s0907444999007350 10.7270/Q2H1308B 10417407 aid1797608 Whitlow, M; Arnaiz, DO; Buckman, BO; Davey, DD; Griedel, B; Guilford, WJ; Koovakkat, SK; Liang, A; Mohan, R; Phillips, GB; Seto, M; Shaw, KJ; Xu, W; Zhao, Z; Light, DR; Morrissey, MM Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17283&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search DX9 1MTW,1FAX 122129 46517461 CHEMBL19902 ZINC03791107 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31185 CN(CC(O)=O)c1c(F)c(Oc2cccc(c2)C2=NCCN2C)nc(Oc2cc(ccc2O)C(N)=N)c1F InChI=1S/C25H24F2N6O5/c1-32-9-8-30-23(32)14-4-3-5-15(10-14)37-24-19(26)21(33(2)12-18(35)36)20(27)25(31-24)38-17-11-13(22(28)29)6-7-16(17)34/h3-7,10-11,34H,8-9,12H2,1-2H3,(H3,28,29)(H,35,36) NPNSVNGQJGRSNR-UHFFFAOYSA-N 17284 2-{[2-(5-carbamimidoyl-2-hydroxyphenoxy)-3,5-difluoro-6-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridin-4-yl](methyl)amino}acetic acid::CHEMBL73193::CI-1031::ZK-807834 Coagulation factor X Homo sapiens 0.11 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi001477q 10.7270/Q2C827JM 11027132 aid1797609 Adler, M; Davey, DD; Phillips, GB; Kim, SH; Jancarik, J; Rumennik, G; Light, DR; Whitlow, M Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17284&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search Z34 1FJS 5353802 46517462 CHEMBL73193 ZINC01902827 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31186 NC(=N)c1ccc(O)c(Oc2cc(cc(Oc3cccc(c3)C3=NCCN3)n2)C(O)=O)c1 InChI=1S/C22H19N5O5/c23-20(24)12-4-5-16(28)17(9-12)32-19-11-14(22(29)30)10-18(27-19)31-15-3-1-2-13(8-15)21-25-6-7-26-21/h1-5,8-11,28H,6-7H2,(H3,23,24)(H,25,26)(H,29,30) KDDSLUYCOZXRQI-UHFFFAOYSA-N 17279 2-(5-carbamimidoyl-2-hydroxyphenoxy)-6-[3-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridine-4-carboxylic acid::CHEMBL315014::Pyridine template, IV::ZK-806688 Coagulation factor X Homo sapiens 85 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi001477q 10.7270/Q2C827JM 11027132 aid1797609 Adler, M; Davey, DD; Phillips, GB; Kim, SH; Jancarik, J; Rumennik, G; Light, DR; Whitlow, M Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17279&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1QBN 10388137 46517457 CHEMBL315014 ZINC12355224 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31187 CN1CCN=C1c1cccc(Oc2nc(Oc3cc(ccc3O)C(N)=N)c(F)c(N3CCCC(C3)C(O)=O)c2F)c1 InChI=1S/C28H28F2N6O5/c1-35-11-9-33-25(35)16-4-2-6-18(12-16)40-26-21(29)23(36-10-3-5-17(14-36)28(38)39)22(30)27(34-26)41-20-13-15(24(31)32)7-8-19(20)37/h2,4,6-8,12-13,17,37H,3,5,9-11,14H2,1H3,(H3,31,32)(H,38,39) NRCRZGGGYMSXER-UHFFFAOYSA-N 17280 1-[2-(5-carbamimidoyl-2-hydroxyphenoxy)-3,5-difluoro-6-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]piperidine-3-carboxylic acid::Pyridine template, V Coagulation factor X Homo sapiens 0.11 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi001477q 10.7270/Q2C827JM 11027132 aid1797609 Adler, M; Davey, DD; Phillips, GB; Kim, SH; Jancarik, J; Rumennik, G; Light, DR; Whitlow, M Berlex http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17280&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1QB1 23441831 46517458 ZINC70690459 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31201 CCOC(=O)CO\N=C(\c1ccccn1)C1(CC1)c1ccc2n(C)c(CNc3ccc(cc3)C(N)=N)nc2c1 InChI=1S/C29H31N7O3/c1-3-38-26(37)18-39-35-27(22-6-4-5-15-32-22)29(13-14-29)20-9-12-24-23(16-20)34-25(36(24)2)17-33-21-10-7-19(8-11-21)28(30)31/h4-12,15-16,33H,3,13-14,17-18H2,1-2H3,(H3,30,31)/b35-27- RNOYCNIZOAIUSV-LSWMGQQCSA-N 17295 BIBT0871::ethyl 2-{[(E)-{[1-(2-{[(4-carbamimidoylphenyl)amino]methyl}-1-methyl-1H-1,3-benzodiazol-5-yl)cyclopropyl](pyridin-2-yl)methylidene}amino]oxy}acetate Coagulation factor X Homo sapiens 57 8 37.00 C Curated from the literature by BindingDB 10.1016/s0969-2126(00)00551-7 10.7270/Q2028PTC 11342132 aid1797614 Nar, H; Bauer, M; Schmid, A; Stassen, JM; Wienen, W; Priepke, HW; Kauffmann, IK; Ries, UJ; Hauel, NH Boehringer Ingelheim Pharma KG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17295&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search T87 1G30,1OYQ,1G2L 9600423 46517473 DB04107 ZINC06409740 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31209 Cc1nc2ccccc2n1Cc1ccc2n(C)c(CNc3ccc(cc3)C(N)=N)nc2c1 InChI=1S/C25H25N7/c1-16-29-20-5-3-4-6-23(20)32(16)15-17-7-12-22-21(13-17)30-24(31(22)2)14-28-19-10-8-18(9-11-19)25(26)27/h3-13,28H,14-15H2,1-2H3,(H3,26,27) IRKPNOLLMNHSOU-UHFFFAOYSA-N 17297 4-[({1-methyl-5-[(2-methyl-1H-1,3-benzodiazol-1-yl)methyl]-1H-1,3-benzodiazol-2-yl}methyl)amino]benzene-1-carboximidamide::BIBR1109 Coagulation factor X Homo sapiens 40 8 37.00 C Curated from the literature by BindingDB 10.1016/s0969-2126(00)00551-7 10.7270/Q2028PTC 11342132 aid1797614 Nar, H; Bauer, M; Schmid, A; Stassen, JM; Wienen, W; Priepke, HW; Kauffmann, IK; Ries, UJ; Hauel, NH Boehringer Ingelheim Pharma KG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17297&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search R11 1G32,1G36,1G2M 445756 46517474 DB02354 ZINC00591050 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31217 Cn1c(CNc2ccc(cc2)C(N)=N)nc2cc(ccc12)C1(CC1)C(=O)N1CCCC1 InChI=1S/C24H28N6O/c1-29-20-9-6-17(24(10-11-24)23(31)30-12-2-3-13-30)14-19(20)28-21(29)15-27-18-7-4-16(5-8-18)22(25)26/h4-9,14,27H,2-3,10-13,15H2,1H3,(H3,25,26) HGNSKHRWYAJRBQ-UHFFFAOYSA-N 17298 4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclopropyl]-1H-1,3-benzodiazol-2-yl}methyl)amino]benzene-1-carboximidamide::BIBM1015 Coagulation factor X Homo sapiens 15 8 37.00 C Curated from the literature by BindingDB 10.1016/s0969-2126(00)00551-7 10.7270/Q2028PTC 11342132 aid1797614 Nar, H; Bauer, M; Schmid, A; Stassen, JM; Wienen, W; Priepke, HW; Kauffmann, IK; Ries, UJ; Hauel, NH Boehringer Ingelheim Pharma KG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17298&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9953722 46517475 ZINC01487774 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33887 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cccc(c1)C(N)=N InChI=1S/C24H22N6O3S/c1-15-13-21(30(29-15)19-6-4-5-17(14-19)23(25)26)24(31)28-18-11-9-16(10-12-18)20-7-2-3-8-22(20)34(27,32)33/h2-14H,1H3,(H3,25,26)(H,28,31)(H2,27,32,33) APFKCRTWNKCURW-UHFFFAOYSA-N 12751 1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::CHEMBL152854::CHEMBL37251::SN-429 Coagulation factor X Homo sapiens 0.013 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12751&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9869498 46513198 CHEMBL37251CHEMBL152854 ZINC02006270 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33888 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cccc(CN)c1 InChI=1S/C24H23N5O3S/c1-16-13-22(29(28-16)20-6-4-5-17(14-20)15-25)24(30)27-19-11-9-18(10-12-19)21-7-2-3-8-23(21)33(26,31)32/h2-14H,15,25H2,1H3,(H,27,30)(H2,26,31,32) RPHPZHQLDZECGT-UHFFFAOYSA-N 18965 1-[3-(aminomethyl)phenyl]-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::CHEMBL134736::pyrazole-based inhibitor, 15a Coagulation factor X Homo sapiens 2.7 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18965&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10769476 46519015 CHEMBL134736 ZINC13527720 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33889 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cccc(N)c1 InChI=1S/C23H21N5O3S/c1-15-13-21(28(27-15)19-6-4-5-17(24)14-19)23(29)26-18-11-9-16(10-12-18)20-7-2-3-8-22(20)32(25,30)31/h2-14H,24H2,1H3,(H,26,29)(H2,25,30,31) KXEVAWQCBZSBMD-UHFFFAOYSA-N 18966 1-(3-aminophenyl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 15b Coagulation factor X Homo sapiens 63 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18966&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11048586 46519016 ZINC13527724 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33890 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1ccccc1N InChI=1S/C23H21N5O3S/c1-15-14-21(28(27-15)20-8-4-3-7-19(20)24)23(29)26-17-12-10-16(11-13-17)18-6-2-5-9-22(18)32(25,30)31/h2-14H,24H2,1H3,(H,26,29)(H2,25,30,31) YWMITEJDOSKUIO-UHFFFAOYSA-N 18967 1-(2-aminophenyl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 15c Coagulation factor X Homo sapiens 600 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18967&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10906426 46519017 ZINC13527728 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33891 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1ccc(N)cc1 InChI=1S/C23H21N5O3S/c1-15-14-21(28(27-15)19-12-8-17(24)9-13-19)23(29)26-18-10-6-16(7-11-18)20-4-2-3-5-22(20)32(25,30)31/h2-14H,24H2,1H3,(H,26,29)(H2,25,30,31) RZAGKOXWYPQVIO-UHFFFAOYSA-N 18968 1-(4-aminophenyl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 15d Coagulation factor X Homo sapiens 3000 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18968&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11059370 46519018 ZINC13527732 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33892 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(CCCCN)n1 InChI=1S/C21H25N5O3S/c1-15-14-19(26(25-15)13-5-4-12-22)21(27)24-17-10-8-16(9-11-17)18-6-2-3-7-20(18)30(23,28)29/h2-3,6-11,14H,4-5,12-13,22H2,1H3,(H,24,27)(H2,23,28,29) MEKRDHSNRSMMJK-UHFFFAOYSA-N 18969 1-(4-aminobutyl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 15e Coagulation factor X Homo sapiens 12000 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18969&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11730277 46519019 ZINC13527736 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33893 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)C1CCCNC1 InChI=1S/C22H25N5O3S/c1-15-13-20(27(26-15)18-5-4-12-24-14-18)22(28)25-17-10-8-16(9-11-17)19-6-2-3-7-21(19)31(23,29)30/h2-3,6-11,13,18,24H,4-5,12,14H2,1H3,(H,25,28)(H2,23,29,30) ODQOVPZYTCNITC-UHFFFAOYSA-N 18970 3-methyl-1-(piperidin-3-yl)-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 15f Coagulation factor X Homo sapiens 21000 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18970&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10928313 46519020 ZINC13527742 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33894 COc1ccc(cc1)-n1nc(C)cc1C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C24H22N4O4S/c1-16-15-22(28(27-16)19-11-13-20(32-2)14-12-19)24(29)26-18-9-7-17(8-10-18)21-5-3-4-6-23(21)33(25,30)31/h3-15H,1-2H3,(H,26,29)(H2,25,30,31) VHPMRGRQOUULNW-UHFFFAOYSA-N 18971 1-(4-methoxyphenyl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::CHEMBL139788::pyrazole-based inhibitor, 22a Coagulation factor X Homo sapiens 11 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18971&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9890540 46519021 CHEMBL139788 ZINC00602733 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33895 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cccc(c1)C(N)=O InChI=1S/C24H21N5O4S/c1-15-13-21(29(28-15)19-6-4-5-17(14-19)23(25)30)24(31)27-18-11-9-16(10-12-18)20-7-2-3-8-22(20)34(26,32)33/h2-14H,1H3,(H2,25,30)(H,27,31)(H2,26,32,33) FJNCTNKQUBFYKT-UHFFFAOYSA-N 18972 1-(3-carbamoylphenyl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 22b Coagulation factor X Homo sapiens 19 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18972&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11049038 46519022 ZINC13527745 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33896 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cccc(Cl)c1 InChI=1S/C23H19ClN4O3S/c1-15-13-21(28(27-15)19-6-4-5-17(24)14-19)23(29)26-18-11-9-16(10-12-18)20-7-2-3-8-22(20)32(25,30)31/h2-14H,1H3,(H,26,29)(H2,25,30,31) DMYOKOORJXDYLZ-UHFFFAOYSA-N 18973 1-(3-chlorophenyl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 22c Coagulation factor X Homo sapiens 37 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18973&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11102692 46519023 ZINC13527748 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33897 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1ccccc1 InChI=1S/C23H20N4O3S/c1-16-15-21(27(26-16)19-7-3-2-4-8-19)23(28)25-18-13-11-17(12-14-18)20-9-5-6-10-22(20)31(24,29)30/h2-15H,1H3,(H,25,28)(H2,24,29,30) FSHMKQSLAPAUNB-UHFFFAOYSA-N 18974 3-methyl-1-phenyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::CHEMBL139121::pyrazole-based inhibitor, 22d Coagulation factor X Homo sapiens 198 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18974&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9824122 46519024 CHEMBL139121 ZINC13527751 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33898 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cccc(c1)C#N InChI=1S/C24H19N5O3S/c1-16-13-22(29(28-16)20-6-4-5-17(14-20)15-25)24(30)27-19-11-9-18(10-12-19)21-7-2-3-8-23(21)33(26,31)32/h2-14H,1H3,(H,27,30)(H2,26,31,32) IFPBHAYHKREZTD-UHFFFAOYSA-N 18975 1-(3-cyanophenyl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 22e Coagulation factor X Homo sapiens 310 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18975&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10790019 46519025 ZINC13527755 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33899 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cccc(c1)S(C)=N InChI=1S/C24H23N5O3S2/c1-16-14-22(29(28-16)19-6-5-7-20(15-19)33(2)25)24(30)27-18-12-10-17(11-13-18)21-8-3-4-9-23(21)34(26,31)32/h3-15,25H,1-2H3,(H,27,30)(H2,26,31,32) PNJIHJHHPABIHF-UHFFFAOYSA-N 18976 3-methyl-1-{3-[(methyl--sulfanyl)amino]phenyl}-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 22f Coagulation factor X Homo sapiens 2700 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18976&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10896308 46519026 ZINC13527762 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33900 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cccc(c1)S(N)(=O)=O InChI=1S/C23H21N5O5S2/c1-15-13-21(28(27-15)18-5-4-6-19(14-18)34(24,30)31)23(29)26-17-11-9-16(10-12-17)20-7-2-3-8-22(20)35(25,32)33/h2-14H,1H3,(H,26,29)(H2,24,30,31)(H2,25,32,33) BQKUELYABDCOLP-UHFFFAOYSA-N 18977 3-methyl-1-(3-sulfamoylphenyl)-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 22g Coagulation factor X Homo sapiens 5000 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18977&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11124077 46519027 ZINC13527766 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33901 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1ccc2onc(N)c2c1 InChI=1S/C24H20N6O4S/c1-14-12-20(30(28-14)17-10-11-21-19(13-17)23(25)29-34-21)24(31)27-16-8-6-15(7-9-16)18-4-2-3-5-22(18)35(26,32)33/h2-13H,1H3,(H2,25,29)(H,27,31)(H2,26,32,33) GMAFNPQQRAPSHH-UHFFFAOYSA-N 18978 1-(3-amino-1,2-benzoxazol-5-yl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 23a Coagulation factor X Homo sapiens 1.4 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18978&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10184785 46519028 ZINC01551420 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33902 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1ccc2[nH]nc(N)c2c1 InChI=1S/C24H21N7O3S/c1-14-12-21(31(30-14)17-10-11-20-19(13-17)23(25)29-28-20)24(32)27-16-8-6-15(7-9-16)18-4-2-3-5-22(18)35(26,33)34/h2-13H,1H3,(H,27,32)(H3,25,28,29)(H2,26,33,34) OHEKCCOBFUNVPU-UHFFFAOYSA-N 18979 1-(3-amino-1H-indazol-5-yl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 23b Coagulation factor X Homo sapiens 29 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18979&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10299889 46519029 ZINC13527770 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33903 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cccc(c1)B(O)O InChI=1S/C23H21BN4O5S/c1-15-13-21(28(27-15)19-6-4-5-17(14-19)24(30)31)23(29)26-18-11-9-16(10-12-18)20-7-2-3-8-22(20)34(25,32)33/h2-14,30-31H,1H3,(H,26,29)(H2,25,32,33) IATABIGBXJIAJO-UHFFFAOYSA-N 18980 1-[3-(dihydroxyboranyl)phenyl]-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::Phenylboronic acid derivative::pyrazole-based inhibitor, 23c Coagulation factor X Homo sapiens 61 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18980&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11826875 46519030 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33904 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1ccc2c(N)n[nH]c2c1 InChI=1S/C24H21N7O3S/c1-14-12-21(31(30-14)17-10-11-19-20(13-17)28-29-23(19)25)24(32)27-16-8-6-15(7-9-16)18-4-2-3-5-22(18)35(26,33)34/h2-13H,1H3,(H,27,32)(H3,25,28,29)(H2,26,33,34) AEYDPNMBTYKTBF-UHFFFAOYSA-N 18981 1-(3-amino-1H-indazol-6-yl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 23d Coagulation factor X Homo sapiens 2800 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18981&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11113694 46519031 ZINC13527773 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33905 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1ccc2ccnc(N)c2c1 InChI=1S/C26H22N6O3S/c1-16-14-23(32(31-16)20-11-8-18-12-13-29-25(27)22(18)15-20)26(33)30-19-9-6-17(7-10-19)21-4-2-3-5-24(21)36(28,34)35/h2-15H,1H3,(H2,27,29)(H,30,33)(H2,28,34,35) AJHNROHOVIQWOE-UHFFFAOYSA-N 18982 1-(1-aminoisoquinolin-7-yl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::SQ-311::pyrazole-based inhibitor, 24a Coagulation factor X Homo sapiens 0.33 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18982&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9892106 46519032 ZINC27442597 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33906 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1ccc2nc(N)nc(N)c2c1 InChI=1S/C25H22N8O3S/c1-14-12-21(33(32-14)17-10-11-20-19(13-17)23(26)31-25(27)30-20)24(34)29-16-8-6-15(7-9-16)18-4-2-3-5-22(18)37(28,35)36/h2-13H,1H3,(H,29,34)(H2,28,35,36)(H4,26,27,30,31) GJSOSYVBARIGQO-UHFFFAOYSA-N 18983 1-(2,4-diaminoquinazolin-6-yl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 24b Coagulation factor X Homo sapiens 16 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18983&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10186048 46519033 ZINC13527777 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33907 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1ccc2ncnc(N)c2c1 InChI=1S/C25H21N7O3S/c1-15-12-22(32(31-15)18-10-11-21-20(13-18)24(26)29-14-28-21)25(33)30-17-8-6-16(7-9-17)19-4-2-3-5-23(19)36(27,34)35/h2-14H,1H3,(H,30,33)(H2,26,28,29)(H2,27,34,35) AWZZHDCUABMZQK-UHFFFAOYSA-N 18984 1-(4-aminoquinazolin-6-yl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 24c Coagulation factor X Homo sapiens 29 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18984&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10228720 46519034 ZINC02006473 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33908 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cccc(c1)C(=N)NO InChI=1S/C24H22N6O4S/c1-15-13-21(30(28-15)19-6-4-5-17(14-19)23(25)29-32)24(31)27-18-11-9-16(10-12-18)20-7-2-3-8-22(20)35(26,33)34/h2-14,32H,1H3,(H2,25,29)(H,27,31)(H2,26,33,34) PXWUQDADEQRCGM-UHFFFAOYSA-N 18985 1-[3-(N'-hydroxycarbamimidoyl)phenyl]-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 24d Coagulation factor X Homo sapiens 19 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18985&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11027375 46519035 ZINC14969374 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33909 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1ccc2ccncc2c1 InChI=1S/C26H21N5O3S/c1-17-14-24(31(30-17)22-11-8-18-12-13-28-16-20(18)15-22)26(32)29-21-9-6-19(7-10-21)23-4-2-3-5-25(23)35(27,33)34/h2-16H,1H3,(H,29,32)(H2,27,33,34) RTIPPPQSZNJPDC-UHFFFAOYSA-N 18986 1-(isoquinolin-7-yl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 24e Coagulation factor X Homo sapiens 370 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18986&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11059945 46519036 ZINC13527787 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33910 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1ccc(N)nc1 InChI=1S/C22H20N6O3S/c1-14-12-19(28(27-14)17-10-11-21(23)25-13-17)22(29)26-16-8-6-15(7-9-16)18-4-2-3-5-20(18)32(24,30)31/h2-13H,1H3,(H2,23,25)(H,26,29)(H2,24,30,31) OHDSMQQIKBOXTD-UHFFFAOYSA-N 18987 1-(6-aminopyridin-3-yl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide::pyrazole-based inhibitor, 24f Coagulation factor X Homo sapiens 1300 7 22.00 C Curated from the literature by BindingDB 10.1021/jm020578e 10.7270/Q2TT4P78 14521405 aid1797809 Lam, PY; Clark, CG; Li, R; Pinto, DJ; Orwat, MJ; Galemmo, RA; Fevig, JM; Teleha, CA; Alexander, RS; Smallwood, AM; Rossi, KA; Wright, MR; Bai, SA; He, K; Luettgen, JM; Wong, PC; Knabb, RM; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18987&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11762113 46519037 ZINC13527791 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33916 COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)C(F)(F)F InChI=1S/C31H29F3N4O3/c1-41-25-12-10-23(11-13-25)38-28-27(29(35-38)31(32,33)34)15-17-37(30(28)40)22-8-6-20(7-9-22)26-5-3-2-4-21(26)18-36-16-14-24(39)19-36/h2-13,24,39H,14-19H2,1H3/t24-/m1/s1 BPIUYWHULQJMGZ-XMMPIXPASA-N 12743 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::CHEMBL221296::dihydropyrazolopyridinone analogue 7c Coagulation factor X Homo sapiens 0.18 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12743&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646181 46513191 CHEMBL221296 ZINC14950606 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33917 COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)S(C)(=O)=O InChI=1S/C31H32N4O5S/c1-40-26-13-11-24(12-14-26)35-29-28(30(32-35)41(2,38)39)16-18-34(31(29)37)23-9-7-21(8-10-23)27-6-4-3-5-22(27)19-33-17-15-25(36)20-33/h3-14,25,36H,15-20H2,1-2H3/t25-/m1/s1 OLQWKYOEBUBVRX-RUZDIDTESA-N 18988 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-3-methanesulfonyl-1-(4-methoxyphenyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::Pyrazolopyridinone analogue, 11a Coagulation factor X Homo sapiens 0.25 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18988&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23636240 46519038 ZINC14969378 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33918 CCOC(=O)c1nn(c2c1CCN(C2=O)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)-c1ccc(OC)cc1 InChI=1S/C33H34N4O5/c1-3-42-33(40)30-29-17-19-36(32(39)31(29)37(34-30)25-12-14-27(41-2)15-13-25)24-10-8-22(9-11-24)28-7-5-4-6-23(28)20-35-18-16-26(38)21-35/h4-15,26,38H,3,16-21H2,1-2H3/t26-/m1/s1 YALQNWIYMBHEMW-AREMUKBSSA-N 18989 Pyrazolopyridinone analogue, 11b::ethyl 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxylate Coagulation factor X Homo sapiens 3.9 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18989&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23636367 46519039 ZINC14969382 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33919 COc1ccc(cc1)-n1nc(C(O)=O)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1 InChI=1S/C31H30N4O5/c1-40-25-12-10-23(11-13-25)35-29-27(28(32-35)31(38)39)15-17-34(30(29)37)22-8-6-20(7-9-22)26-5-3-2-4-21(26)18-33-16-14-24(36)19-33/h2-13,24,36H,14-19H2,1H3,(H,38,39)/t24-/m1/s1 LXAASMXDKITPJA-XMMPIXPASA-N 18990 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxylic acid::Pyrazolopyridinone analogue, 12 Coagulation factor X Homo sapiens 7.6 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18990&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23636368 46519040 ZINC14969387 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33920 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1 InChI=1S/C31H31N5O4/c1-40-25-12-10-23(11-13-25)36-29-27(28(33-36)30(32)38)15-17-35(31(29)39)22-8-6-20(7-9-22)26-5-3-2-4-21(26)18-34-16-14-24(37)19-34/h2-13,24,37H,14-19H2,1H3,(H2,32,38)/t24-/m1/s1 DHISSSXEEMPPQB-XMMPIXPASA-N 18991 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Pyrazolopyridinone analogue, 13f Coagulation factor X Homo sapiens 0.07 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18991&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23636371 46519041 ZINC14969391 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33921 CNC(=O)c1nn(c2c1CCN(C2=O)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)-c1ccc(OC)cc1 InChI=1S/C32H33N5O4/c1-33-31(39)29-28-16-18-36(32(40)30(28)37(34-29)24-11-13-26(41-2)14-12-24)23-9-7-21(8-10-23)27-6-4-3-5-22(27)19-35-17-15-25(38)20-35/h3-14,25,38H,15-20H2,1-2H3,(H,33,39)/t25-/m1/s1 KXKURQAXASTNBV-RUZDIDTESA-N 18992 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-N-methyl-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Pyrazolopyridinone analogue, 15a Coagulation factor X Homo sapiens 4.8 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18992&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23635503 46519042 ZINC14969393 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33922 COc1ccc(cc1)-n1nc(C(=O)N(C)C)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1 InChI=1S/C33H35N5O4/c1-35(2)32(40)30-29-17-19-37(33(41)31(29)38(34-30)25-12-14-27(42-3)15-13-25)24-10-8-22(9-11-24)28-7-5-4-6-23(28)20-36-18-16-26(39)21-36/h4-15,26,39H,16-21H2,1-3H3/t26-/m1/s1 WLBWFTGACLTMDU-AREMUKBSSA-N 18993 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-N,N-dimethyl-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Pyrazolopyridinone analogue, 15b Coagulation factor X Homo sapiens 1.7 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18993&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23634638 46519043 ZINC14969397 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33923 COc1ccc(cc1)-n1nc(C#N)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1 InChI=1S/C31H29N5O3/c1-39-26-12-10-24(11-13-26)36-30-28(29(18-32)33-36)15-17-35(31(30)38)23-8-6-21(7-9-23)27-5-3-2-4-22(27)19-34-16-14-25(37)20-34/h2-13,25,37H,14-17,19-20H2,1H3/t25-/m1/s1 HSEWIGIEWJQWBI-RUZDIDTESA-N 18994 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carbonitrile::Pyrazolopyridinone analogue, 18 Coagulation factor X Homo sapiens 0.33 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18994&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23634640 46519044 ZINC14969401 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33924 COc1ccc(cc1)-n1nc(NC(=O)OC(C)(C)C)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1 InChI=1S/C35H39N5O5/c1-35(2,3)45-34(43)36-32-30-18-20-39(33(42)31(30)40(37-32)26-13-15-28(44-4)16-14-26)25-11-9-23(10-12-25)29-8-6-5-7-24(29)21-38-19-17-27(41)22-38/h5-16,27,41H,17-22H2,1-4H3,(H,36,37,43)/t27-/m1/s1 ZGFNARQDWZHFIU-HHHXNRCGSA-N 18995 Pyrazolopyridinone analogue, 21::tert-butyl N-{6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-3-yl}carbamate Coagulation factor X Homo sapiens 9.6 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18995&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23634756 46519045 ZINC14969405 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33925 COc1ccc(cc1)-n1nc(N)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1 InChI=1S/C30H31N5O3/c1-38-25-12-10-23(11-13-25)35-28-27(29(31)32-35)15-17-34(30(28)37)22-8-6-20(7-9-22)26-5-3-2-4-21(26)18-33-16-14-24(36)19-33/h2-13,24,36H,14-19H2,1H3,(H2,31,32)/t24-/m1/s1 IWJWKIXKIBPVSL-XMMPIXPASA-N 18996 3-amino-6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::Pyrazolopyridinone analogue, 22 Coagulation factor X Homo sapiens 6.7 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18996&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23634757 46519046 ZINC14969409 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33926 COc1ccc(cc1)-n1nc(N(C)C(=O)OC(C)(C)C)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1 InChI=1S/C36H41N5O5/c1-36(2,3)46-35(44)38(4)33-31-19-21-40(34(43)32(31)41(37-33)27-14-16-29(45-5)17-15-27)26-12-10-24(11-13-26)30-9-7-6-8-25(30)22-39-20-18-28(42)23-39/h6-17,28,42H,18-23H2,1-5H3/t28-/m1/s1 WAGIMACQVHFHAK-MUUNZHRXSA-N 18997 Pyrazolopyridinone analogue, 23::tert-butyl N-{6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-3-yl}-N-methylcarbamate Coagulation factor X Homo sapiens 2.0 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18997&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23634758 46509623 ZINC14969413 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33927 CNc1nn(c2c1CCN(C2=O)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)-c1ccc(OC)cc1 InChI=1S/C31H33N5O3/c1-32-30-28-16-18-35(31(38)29(28)36(33-30)24-11-13-26(39-2)14-12-24)23-9-7-21(8-10-23)27-6-4-3-5-22(27)19-34-17-15-25(37)20-34/h3-14,25,37H,15-20H2,1-2H3,(H,32,33)/t25-/m1/s1 CFMAGVSIRHKWHW-RUZDIDTESA-N 18998 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-3-(methylamino)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::Pyrazolopyridinone analogue, 24 Coagulation factor X Homo sapiens 1.7 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18998&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23634877 46519047 ZINC14969417 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33928 COc1ccc(cc1)-n1nc(N(C)C)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1 InChI=1S/C32H35N5O3/c1-34(2)31-29-17-19-36(32(39)30(29)37(33-31)25-12-14-27(40-3)15-13-25)24-10-8-22(9-11-24)28-7-5-4-6-23(28)20-35-18-16-26(38)21-35/h4-15,26,38H,16-21H2,1-3H3/t26-/m1/s1 JJEPTCSFQFAEHF-AREMUKBSSA-N 18999 3-(dimethylamino)-6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::Pyrazolopyridinone analogue, 25 Coagulation factor X Homo sapiens 0.31 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18999&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23634878 46519048 ZINC14969421 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33929 COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)-c1nnnn1C InChI=1S/C32H32N8O3/c1-37-31(33-35-36-37)29-28-16-18-39(32(42)30(28)40(34-29)24-11-13-26(43-2)14-12-24)23-9-7-21(8-10-23)27-6-4-3-5-22(27)19-38-17-15-25(41)20-38/h3-14,25,41H,15-20H2,1-2H3/t25-/m1/s1 YNHPVNOJZLBEMX-RUZDIDTESA-N 19000 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-3-(1-methyl-1H-1,2,3,4-tetrazol-5-yl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::Pyrazolopyridinone analogue, 27 Coagulation factor X Homo sapiens 2.3 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19000&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23634880 46519049 ZINC14969426 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33930 COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1)-c1nnn[nH]1 InChI=1S/C31H30N8O3/c1-42-25-12-10-23(11-13-25)39-29-27(28(34-39)30-32-35-36-33-30)15-17-38(31(29)41)22-8-6-20(7-9-22)26-5-3-2-4-21(26)18-37-16-14-24(40)19-37/h2-13,24,40H,14-19H2,1H3,(H,32,33,35,36)/t24-/m1/s1 RCLCUBQVOBFWDF-XMMPIXPASA-N 19001 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-3-(1H-1,2,3,4-tetrazol-5-yl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::Pyrazolopyridinone analogue, 28 Coagulation factor X Homo sapiens 0.63 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19001&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23634881 46519050 ZINC14969430 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33931 COc1ccc(cc1)-n1nc(Cn2ccnn2)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1 InChI=1S/C33H33N7O3/c1-43-28-12-10-26(11-13-28)40-32-30(31(35-40)22-38-19-16-34-36-38)15-18-39(33(32)42)25-8-6-23(7-9-25)29-5-3-2-4-24(29)20-37-17-14-27(41)21-37/h2-13,16,19,27,41H,14-15,17-18,20-22H2,1H3/t27-/m1/s1 WEKJJVKHRKQPFJ-HHHXNRCGSA-N 19002 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-3-(1H-1,2,3-triazol-1-ylmethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::Pyrazolopyridinone analogue, 33a Coagulation factor X Homo sapiens 0.67 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19002&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23635626 46519051 ZINC14969434 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33932 COc1ccc(cc1)-n1nc(Cn2nccn2)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1 InChI=1S/C33H33N7O3/c1-43-28-12-10-26(11-13-28)40-32-30(31(36-40)22-39-34-16-17-35-39)15-19-38(33(32)42)25-8-6-23(7-9-25)29-5-3-2-4-24(29)20-37-18-14-27(41)21-37/h2-13,16-17,27,41H,14-15,18-22H2,1H3/t27-/m1/s1 JFZUXBACKAQZEY-HHHXNRCGSA-N 19003 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-3-(2H-1,2,3-triazol-2-ylmethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::Pyrazolopyridinone analogue, 33b Coagulation factor X Homo sapiens 0.48 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19003&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23635132 46519052 ZINC14969439 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33933 COc1ccc(cc1)-n1nc(Cn2cncn2)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1 InChI=1S/C33H33N7O3/c1-43-28-12-10-26(11-13-28)40-32-30(31(36-40)20-38-22-34-21-35-38)15-17-39(33(32)42)25-8-6-23(7-9-25)29-5-3-2-4-24(29)18-37-16-14-27(41)19-37/h2-13,21-22,27,41H,14-20H2,1H3/t27-/m1/s1 CDRVDOQSQDVYKT-HHHXNRCGSA-N 19004 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-3-(1H-1,2,4-triazol-1-ylmethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::Pyrazolopyridinone analogue, 33c Coagulation factor X Homo sapiens 0.25 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19004&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23635750 46519053 ZINC14969443 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33934 COc1ccc(cc1)-n1nc(Cn2cnnn2)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1 InChI=1S/C32H32N8O3/c1-43-27-12-10-25(11-13-27)40-31-29(30(34-40)20-38-21-33-35-36-38)15-17-39(32(31)42)24-8-6-22(7-9-24)28-5-3-2-4-23(28)18-37-16-14-26(41)19-37/h2-13,21,26,41H,14-20H2,1H3/t26-/m1/s1 XSEZTBVLOUTJTF-AREMUKBSSA-N 19005 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-3-(1H-1,2,3,4-tetrazol-1-ylmethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::Pyrazolopyridinone analogue, 33d Coagulation factor X Homo sapiens 0.85 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19005&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23635133 46519054 ZINC14969448 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33935 COc1ccc(cc1)-n1nc(Cn2ncnn2)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CC[C@@H](O)C1 InChI=1S/C32H32N8O3/c1-43-27-12-10-25(11-13-27)40-31-29(30(35-40)20-39-34-21-33-36-39)15-17-38(32(31)42)24-8-6-22(7-9-24)28-5-3-2-4-23(28)18-37-16-14-26(41)19-37/h2-13,21,26,41H,14-20H2,1H3/t26-/m1/s1 UAIGJMNMKWFEGL-AREMUKBSSA-N 19006 6-[4-(2-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-3-(2H-1,2,3,4-tetrazol-2-ylmethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::Pyrazolopyridinone analogue, 33e Coagulation factor X Homo sapiens 1.1 7 22.00 C Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19006&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23635260 46519055 ZINC14969454 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33936 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN InChI=1S/C27H25N5O3/c1-35-21-12-10-20(11-13-21)32-25-23(24(30-32)26(29)33)14-15-31(27(25)34)19-8-6-17(7-9-19)22-5-3-2-4-18(22)16-28/h2-13H,14-16,28H2,1H3,(H2,29,33) GNENBXDFTFJVCO-UHFFFAOYSA-N 19007 6-{4-[2-(aminomethyl)phenyl]phenyl}-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::C-3 Carboxamido Pyrazole, 13a Coagulation factor X Homo sapiens 0.97 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19007&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10139899 46519056 ZINC14969459 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33937 CNCc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1ccc(OC)cc1)C(N)=O InChI=1S/C28H27N5O3/c1-30-17-19-5-3-4-6-23(19)18-7-9-20(10-8-18)32-16-15-24-25(27(29)34)31-33(26(24)28(32)35)21-11-13-22(36-2)14-12-21/h3-14,30H,15-17H2,1-2H3,(H2,29,34) WBJAPJNKSSQXAT-UHFFFAOYSA-N 19008 1-(4-methoxyphenyl)-6-(4-{2-[(methylamino)methyl]phenyl}phenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::C-3 Carboxamido Pyrazole, 13b::CHEMBL237226 Coagulation factor X Homo sapiens 0.14 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19008&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10116752 46519057 CHEMBL237226 ZINC14969463 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33938 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN(C)C InChI=1S/C29H29N5O3/c1-32(2)18-20-6-4-5-7-24(20)19-8-10-21(11-9-19)33-17-16-25-26(28(30)35)31-34(27(25)29(33)36)22-12-14-23(37-3)15-13-22/h4-15H,16-18H2,1-3H3,(H2,30,35) WDTKVYDFBNLOOJ-UHFFFAOYSA-N 19009 6-(4-{2-[(dimethylamino)methyl]phenyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::C-3 Carboxamido Pyrazole, 13c Coagulation factor X Homo sapiens 0.24 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19009&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10117541 46519058 ZINC14969467 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33939 CCN(CC)Cc1ccccc1-c1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1ccc(OC)cc1)C(N)=O InChI=1S/C31H33N5O3/c1-4-34(5-2)20-22-8-6-7-9-26(22)21-10-12-23(13-11-21)35-19-18-27-28(30(32)37)33-36(29(27)31(35)38)24-14-16-25(39-3)17-15-24/h6-17H,4-5,18-20H2,1-3H3,(H2,32,37) VTHIZWRLBYQAKK-UHFFFAOYSA-N 19010 6-(4-{2-[(diethylamino)methyl]phenyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::C-3 Carboxamido Pyrazole, 13d Coagulation factor X Homo sapiens 0.08 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19010&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23636369 46519059 ZINC14969471 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33940 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CCCC1 InChI=1S/C31H31N5O3/c1-39-25-14-12-24(13-15-25)36-29-27(28(33-36)30(32)37)16-19-35(31(29)38)23-10-8-21(9-11-23)26-7-3-2-6-22(26)20-34-17-4-5-18-34/h2-3,6-15H,4-5,16-20H2,1H3,(H2,32,37) AZWOHKZXJMIDFB-UHFFFAOYSA-N 19011 1-(4-methoxyphenyl)-7-oxo-6-{4-[2-(pyrrolidin-1-ylmethyl)phenyl]phenyl}-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::C-3 Carboxamido Pyrazole, 13e Coagulation factor X Homo sapiens 0.3 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19011&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23636370 46519060 ZINC14969475 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33941 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN1CCC(O)CC1 InChI=1S/C32H33N5O4/c1-41-26-12-10-24(11-13-26)37-30-28(29(34-37)31(33)39)16-19-36(32(30)40)23-8-6-21(7-9-23)27-5-3-2-4-22(27)20-35-17-14-25(38)15-18-35/h2-13,25,38H,14-20H2,1H3,(H2,33,39) WYYUKFPDEPUPIJ-UHFFFAOYSA-N 19012 6-(4-{2-[(4-hydroxypiperidin-1-yl)methyl]phenyl}phenyl)-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::C-3 Carboxamido Pyrazole, 13g Coagulation factor X Homo sapiens 0.29 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19012&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 12989060 46519061 ZINC14969479 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31650 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H24ClN3O5S/c1-14(20(26)24-8-10-30-11-9-24)25-7-6-19(21(25)27)23-31(28,29)18-5-3-15-12-17(22)4-2-16(15)13-18/h2-5,12-14,19,23H,6-11H2,1H3/t14-,19-/m0/s1 ICLOZQFWTRAYPX-LIRRHRJNSA-N 12538 6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1a::aminopyrrolidin-2-one 1::pyrrolidin-2-one-based inhibitor 24 Coagulation factor X Homo sapiens 6 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12538&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GSK 2CJI 6852168 46512997 DB07847 ZINC14950061 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31651 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc(s2)-c2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H22ClN3O5S3/c1-12(18(24)22-8-10-28-11-9-22)23-7-6-13(19(23)25)21-31(26,27)17-5-3-15(30-17)14-2-4-16(20)29-14/h2-5,12-13,21H,6-11H2,1H3/t12-,13-/m0/s1 NAHOZYBRUMVDSR-STQMWFEESA-N 17641 5-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]thiophene-2-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1b Coagulation factor X Homo sapiens 4 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17641&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GSX 2J95 10118017 46517803 ZINC14965148 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31652 C[C@H](N1CC[C@H](NS(=O)(=O)\C=C\c2ccc(Cl)cc2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H24ClN3O5S/c1-14(18(24)22-9-11-28-12-10-22)23-8-6-17(19(23)25)21-29(26,27)13-7-15-2-4-16(20)5-3-15/h2-5,7,13-14,17,21H,6,8-12H2,1H3/b13-7+/t14-,17-/m0/s1 DNCVZNVETAOAJO-PPYZAHLJSA-N 17642 (E)-2-(4-chlorophenyl)-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]ethene-1-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1c Coagulation factor X Homo sapiens 11 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17642&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 4O6 4Y79 9803364 46517804 ZINC14965153 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31653 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3cc(Cl)ccc3s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H22ClN3O5S2/c1-12(18(24)22-6-8-28-9-7-22)23-5-4-15(19(23)25)21-30(26,27)17-11-13-10-14(20)2-3-16(13)29-17/h2-3,10-12,15,21H,4-9H2,1H3/t12-,15-/m0/s1 LTJNKFUIOOJXNJ-WFASDCNBSA-N 12546 5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide::Arylsulfonamide 1b::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1d Coagulation factor X Homo sapiens 47 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12546&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GS5 2J38 9549259 46513005 DB07843 ZINC14950088 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31654 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3ccc(Cl)cc3s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H22ClN3O5S2/c1-12(18(24)22-6-8-28-9-7-22)23-5-4-15(19(23)25)21-30(26,27)17-10-13-2-3-14(20)11-16(13)29-17/h2-3,10-12,15,21H,4-9H2,1H3/t12-,15-/m0/s1 PHLKBODTBJLXRD-WFASDCNBSA-N 12547 6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1-benzothiophene-2-sulfonamide::Arylsulfonamide 1a::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1e Coagulation factor X Homo sapiens 15 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12547&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GS6 2J34 9549258 46513006 DB07844 ZINC14950092 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31655 C[C@H](N1CC[C@H](NS(=O)(=O)\C=C\c2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C17H22ClN3O5S2/c1-12(16(22)20-7-9-26-10-8-20)21-6-4-14(17(21)23)19-28(24,25)11-5-13-2-3-15(18)27-13/h2-3,5,11-12,14,19H,4,6-10H2,1H3/b11-5+/t12-,14-/m0/s1 ACEFOQMQINFMRW-DYCFVMESSA-N 17643 (E)-2-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]ethene-1-sulfonamide::CHEMBL220050::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1f Coagulation factor X Homo sapiens 4 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17643&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 895 2JH5,2UWL 9911502 46517805 CHEMBL220050 DB07278 ZINC14965157 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31656 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc3cc(C)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C22H27N3O5S/c1-15-3-4-18-14-19(6-5-17(18)13-15)31(28,29)23-20-7-8-25(22(20)27)16(2)21(26)24-9-11-30-12-10-24/h3-6,13-14,16,20,23H,7-12H2,1-2H3/t16-,20-/m0/s1 DENIYDALOCHOMF-JXFKEZNVSA-N 17644 6-methyl-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1g Coagulation factor X Homo sapiens 109 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17644&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16124699 46517806 ZINC14965161 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31657 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3sc(Cl)cc3s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C17H20ClN3O5S3/c1-10(16(22)20-4-6-26-7-5-20)21-3-2-11(17(21)23)19-29(24,25)15-9-13-12(28-15)8-14(18)27-13/h8-11,19H,2-7H2,1H3/t10-,11-/m0/s1 ULFIHLYNTSPKQF-QWRGUYRKSA-N 17645 5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]thieno[3,2-b]thiophene-2-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1h Coagulation factor X Homo sapiens 165 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17645&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16124700 46517807 ZINC14965166 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31658 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc(\C=C\Cl)cc2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H24ClN3O5S/c1-14(18(24)22-10-12-28-13-11-22)23-9-7-17(19(23)25)21-29(26,27)16-4-2-15(3-5-16)6-8-20/h2-6,8,14,17,21H,7,9-13H2,1H3/b8-6+/t14-,17-/m0/s1 WOGATBPZVOVBNK-LRPCFIKCSA-N 17646 4-[(E)-2-chloroethenyl]-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]benzene-1-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1i Coagulation factor X Homo sapiens 314 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17646&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16125613 46517808 ZINC14965170 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31659 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3nc(Cl)ccc3s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C18H21ClN4O5S2/c1-11(17(24)22-6-8-28-9-7-22)23-5-4-12(18(23)25)21-30(26,27)16-10-13-14(29-16)2-3-15(19)20-13/h2-3,10-12,21H,4-9H2,1H3/t11-,12-/m0/s1 RWEHNUQJZCUXIC-RYUDHWBXSA-N 17647 5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]thieno[3,2-b]pyridine-2-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1j Coagulation factor X Homo sapiens 163 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17647&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16124701 46517809 ZINC14965174 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31660 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3cc(Cl)cnc3s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C18H21ClN4O5S2/c1-11(17(24)22-4-6-28-7-5-22)23-3-2-14(18(23)25)21-30(26,27)15-9-12-8-13(19)10-20-16(12)29-15/h8-11,14,21H,2-7H2,1H3/t11-,14-/m0/s1 KBXRTVCEMYXBCG-FZMZJTMJSA-N 17648 5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]thieno[2,3-b]pyridine-2-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1k Coagulation factor X Homo sapiens 2898 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17648&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16124702 46517810 ZINC14965178 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31661 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3ncc(Cl)cc3s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C18H21ClN4O5S2/c1-11(17(24)22-4-6-28-7-5-22)23-3-2-13(18(23)25)21-30(26,27)16-9-14-15(29-16)8-12(19)10-20-14/h8-11,13,21H,2-7H2,1H3/t11-,13-/m0/s1 STFCHVHDCAKEKC-AAEUAGOBSA-N 17649 6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]thieno[3,2-b]pyridine-2-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1l Coagulation factor X Homo sapiens 3670 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17649&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16125614 46517811 ZINC14965182 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31662 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc(s2)-c2nnc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C17H20ClN5O5S3/c1-10(15(24)22-6-8-28-9-7-22)23-5-4-11(16(23)25)21-31(26,27)13-3-2-12(29-13)14-19-20-17(18)30-14/h2-3,10-11,21H,4-9H2,1H3/t10-,11-/m0/s1 JRSNMAKJGFZLQH-QWRGUYRKSA-N 17650 5-(5-chloro-1,3,4-thiadiazol-2-yl)-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]thiophene-2-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1m Coagulation factor X Homo sapiens >15800 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17650&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16124703 46517812 ZINC14965186 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31663 C[C@H](N1CC[C@H](NS(=O)(=O)c2ccc(s2)-c2ncc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C18H21ClN4O5S3/c1-11(17(24)22-6-8-28-9-7-22)23-5-4-12(18(23)25)21-31(26,27)15-3-2-13(29-15)16-20-10-14(19)30-16/h2-3,10-12,21H,4-9H2,1H3/t11-,12-/m0/s1 UYLYPFPUTRRLTD-RYUDHWBXSA-N 17651 5-(5-chloro-1,3-thiazol-2-yl)-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]thiophene-2-sulfonamide::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1n Coagulation factor X Homo sapiens 3225 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17651&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16125615 46517813 ZINC14965190 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31664 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3ccc(Cl)cc3o2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H22ClN3O6S/c1-12(18(24)22-6-8-28-9-7-22)23-5-4-15(19(23)25)21-30(26,27)17-10-13-2-3-14(20)11-16(13)29-17/h2-3,10-12,15,21H,4-9H2,1H3/t12-,15-/m0/s1 XNSIFTKEVAXGSM-WFASDCNBSA-N 12553 6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1-benzofuran-2-sulfonamide::Arylsulfonamide 4a::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1o Coagulation factor X Homo sapiens 285 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12553&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16124704 46513012 ZINC14950113 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31665 C[C@H](N1CC[C@H](NS(=O)(=O)c2cc3cc(Cl)ccc3o2)C1=O)C(=O)N1CCOCC1 InChI=1S/C19H22ClN3O6S/c1-12(18(24)22-6-8-28-9-7-22)23-5-4-15(19(23)25)21-30(26,27)17-11-13-10-14(20)2-3-16(13)29-17/h2-3,10-12,15,21H,4-9H2,1H3/t12-,15-/m0/s1 LHWFJBCPONIVNC-WFASDCNBSA-N 12552 5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1-benzofuran-2-sulfonamide::Arylsulfonamide 4b::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1p Coagulation factor X Homo sapiens 782 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12552&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16125616 46513011 ZINC14950110 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31666 C[C@H](N1CC[C@H](NS(=O)(=O)c2nc3ccc(Cl)cc3s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C18H21ClN4O5S2/c1-11(16(24)22-6-8-28-9-7-22)23-5-4-14(17(23)25)21-30(26,27)18-20-13-3-2-12(19)10-15(13)29-18/h2-3,10-11,14,21H,4-9H2,1H3/t11-,14-/m0/s1 KOOMWRKYGHYHOT-FZMZJTMJSA-N 12549 6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1,3-benzothiazole-2-sulfonamide::Arylsulfonamide 2a::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1q Coagulation factor X Homo sapiens 4160 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12549&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16124761 46513008 ZINC14950100 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 31667 C[C@H](N1CC[C@H](NS(=O)(=O)c2nc3cc(Cl)ccc3s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C18H21ClN4O5S2/c1-11(16(24)22-6-8-28-9-7-22)23-5-4-13(17(23)25)21-30(26,27)18-20-14-10-12(19)2-3-15(14)29-18/h2-3,10-11,13,21H,4-9H2,1H3/t11-,13-/m0/s1 SRLCBDHMFDIPRY-AAEUAGOBSA-N 12548 5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-1,3-benzothiazole-2-sulfonamide::Arylsulfonamide 2b::N-[(3S)-2-oxopyrrolidin-3-yl]sulfonamide, 1r Coagulation factor X Homo sapiens 112 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm060870c 10.7270/Q2F18X06 17338508 aid1797640 Chan, C; Borthwick, AD; Brown, D; Burns-Kurtis, CL; Campbell, M; Chaudry, L; Chung, CW; Convery, MA; Hamblin, JN; Johnstone, L; Kelly, HA; Kleanthous, S; Patikis, A; Patel, C; Pateman, AJ; Senger, S; Shah, GP; Toomey, JR; Watson, NS; Weston, HE; Whitworth, C; Young, RJ; Zhou, P GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12548&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16124762 46513007 ZINC14950097 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33942 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)-c1ccccc1CN(CCO)CCO InChI=1S/C31H33N5O5/c1-41-25-12-10-24(11-13-25)36-29-27(28(33-36)30(32)39)14-15-35(31(29)40)23-8-6-21(7-9-23)26-5-3-2-4-22(26)20-34(16-18-37)17-19-38/h2-13,37-38H,14-20H2,1H3,(H2,32,39) OOPKOOPFWNIDJI-UHFFFAOYSA-N 19013 6-[4-(2-{[bis(2-hydroxyethyl)amino]methyl}phenyl)phenyl]-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::C-3 Carboxamido Pyrazole, 13h Coagulation factor X Homo sapiens 0.36 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19013&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20872059 46519062 ZINC14969483 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33943 COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(N)cc1)C(F)(F)F InChI=1S/C20H17F3N4O2/c1-29-15-8-6-14(7-9-15)27-17-16(18(25-27)20(21,22)23)10-11-26(19(17)28)13-4-2-12(24)3-5-13/h2-9H,10-11,24H2,1H3 OGVWKHPUKXDHAB-UHFFFAOYSA-N 19014 6-(4-aminophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::trifluoromethylpyrazole analogue, 34 Coagulation factor X Homo sapiens 1600 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19014&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23635261 46519063 ZINC14969487 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33944 COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(NC(C)=O)cc1)C(F)(F)F InChI=1S/C22H19F3N4O3/c1-13(30)26-14-3-5-15(6-4-14)28-12-11-18-19(21(28)31)29(27-20(18)22(23,24)25)16-7-9-17(32-2)10-8-16/h3-10H,11-12H2,1-2H3,(H,26,30) IOBGUEKYOXMMMZ-UHFFFAOYSA-N 19015 N-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}acetamide::trifluoromethylpyrazole analogue, 35 Coagulation factor X Homo sapiens 180 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19015&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23635262 46519064 ZINC14969492 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33945 CNc1ccc(cc1)N1CCc2c(nn(c2C1=O)-c1ccc(OC)cc1)C(F)(F)F InChI=1S/C21H19F3N4O2/c1-25-13-3-5-14(6-4-13)27-12-11-17-18(20(27)29)28(26-19(17)21(22,23)24)15-7-9-16(30-2)10-8-15/h3-10,25H,11-12H2,1-2H3 LRJGICFBUGSISP-UHFFFAOYSA-N 19016 1-(4-methoxyphenyl)-6-[4-(methylamino)phenyl]-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::trifluoromethylpyrazole analogue, 36c Coagulation factor X Homo sapiens 610 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19016&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23635752 46519065 ZINC14969496 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33946 COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)N(C)C(C)=O)C(F)(F)F InChI=1S/C23H21F3N4O3/c1-14(31)28(2)15-4-6-16(7-5-15)29-13-12-19-20(22(29)32)30(27-21(19)23(24,25)26)17-8-10-18(33-3)11-9-17/h4-11H,12-13H2,1-3H3 JEEDSFZNOOUNBM-UHFFFAOYSA-N 19017 N-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}-N-methylacetamide::trifluoromethylpyrazole analogue, 36d Coagulation factor X Homo sapiens 0.5 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19017&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23635264 46519066 ZINC14969499 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33947 COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)N(C)C)C(F)(F)F InChI=1S/C22H21F3N4O2/c1-27(2)14-4-6-15(7-5-14)28-13-12-18-19(21(28)30)29(26-20(18)22(23,24)25)16-8-10-17(31-3)11-9-16/h4-11H,12-13H2,1-3H3 OJHOOIOSDPIZFU-UHFFFAOYSA-N 19018 6-[4-(dimethylamino)phenyl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::trifluoromethylpyrazole analogue, 36e Coagulation factor X Homo sapiens 6 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19018&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23635753 46519067 ZINC14969503 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33948 COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1)C(F)(F)F InChI=1S/C25H25F3N4O2/c1-34-20-11-9-19(10-12-20)32-22-21(23(29-32)25(26,27)28)13-16-31(24(22)33)18-7-5-17(6-8-18)30-14-3-2-4-15-30/h5-12H,2-4,13-16H2,1H3 OALCVKVJNNZBEH-UHFFFAOYSA-N 19019 1-(4-methoxyphenyl)-6-[4-(piperidin-1-yl)phenyl]-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-7-one::trifluoromethylpyrazole analogue, 37 Coagulation factor X Homo sapiens 2.1 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19019&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23635386 46519068 ZINC14969507 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33949 COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O)C(F)(F)F InChI=1S/C25H23F3N4O3/c1-35-19-11-9-18(10-12-19)32-22-20(23(29-32)25(26,27)28)13-15-31(24(22)34)17-7-5-16(6-8-17)30-14-3-2-4-21(30)33/h5-12H,2-4,13-15H2,1H3 ADVBFHLRMYDWJH-UHFFFAOYSA-N 19020 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}piperidin-2-one::trifluoromethylpyrazole analogue, 38a Coagulation factor X Homo sapiens 0.23 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19020&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10299701 46519069 ZINC14969511 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33950 COc1ccc(cc1)-n1nc(c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCCC1=O)C(F)(F)F InChI=1S/C26H25F3N4O3/c1-36-20-12-10-19(11-13-20)33-23-21(24(30-33)26(27,28)29)14-16-32(25(23)35)18-8-6-17(7-9-18)31-15-4-2-3-5-22(31)34/h6-13H,2-5,14-16H2,1H3 XQRZFLUPOAPZLV-UHFFFAOYSA-N 19021 1-{4-[1-(4-methoxyphenyl)-7-oxo-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-6-yl]phenyl}azepan-2-one::trifluoromethylpyrazole analogue, 38b Coagulation factor X Homo sapiens 0.47 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19021&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10300491 46519070 ZINC14969515 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33951 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N(C)C(C)=O InChI=1S/C23H23N5O4/c1-14(29)26(2)15-4-6-16(7-5-15)27-13-12-19-20(22(24)30)25-28(21(19)23(27)31)17-8-10-18(32-3)11-9-17/h4-11H,12-13H2,1-3H3,(H2,24,30) FDHXDGIWUSXLEQ-UHFFFAOYSA-N 19022 1-(4-methoxyphenyl)-6-[4-(N-methylacetamido)phenyl]-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::acetylated N-methyl analogue, 47 Coagulation factor X Homo sapiens 0.61 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19022&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23635500 46519071 ZINC14969518 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33952 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32) QNZCBYKSOIHPEH-UHFFFAOYSA-N 19023 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Apixaban::BMS-562247::CHEMBL231779::US9938272, Example Apixaban Coagulation factor X Homo sapiens 0.08 Curated from the literature by BindingDB 10.1021/jm070245n 10.7270/Q2Q23XJ9 17914785 aid1797810 Pinto, DJ; Orwat, MJ; Koch, S; Rossi, KA; Alexander, RS; Smallwood, A; Wong, PC; Rendina, AR; Luettgen, JM; Knabb, RM; He, K; Xin, B; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19023&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GG2 2P16,6W70 10182969 46519072 72296 CHEMBL231779 DB06605 6390 ZINC11677837 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33983 CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)c2cc(nn2-c2cccc(CN)c2)C(F)(F)F)c(F)c1 InChI=1S/C25H20F4N4O3S/c1-37(35,36)22-8-3-2-7-18(22)16-9-10-20(19(26)12-16)31-24(34)21-13-23(25(27,28)29)32-33(21)17-6-4-5-15(11-17)14-30/h2-13H,14,30H2,1H3,(H,31,34) ZLUOAFAJSUPHOG-UHFFFAOYSA-N 12657 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2-(methylsulfonyl)-[1,1-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::1-[3-(aminomethyl)phenyl]-N-[2-fluoro-4-(2-methanesulfonylphenyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::CHEMBL559015::DPC 423::DPC423 Coagulation factor X Homo sapiens 0.3 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12657&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search M35 3M35,3M36 9895762 46513110 CHEMBL559015 ZINC01490578 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33984 CS(=O)(=O)c1ccccc1C1=CCC(CC1)NC(=O)c1cc(nn1-c1cccc(CN)c1)C(F)(F)F InChI=1S/C25H25F3N4O3S/c1-36(34,35)22-8-3-2-7-20(22)17-9-11-18(12-10-17)30-24(33)21-14-23(25(26,27)28)31-32(21)19-6-4-5-16(13-19)15-29/h2-9,13-14,18H,10-12,15,29H2,1H3,(H,30,33) IDPQJBRATBKSKF-UHFFFAOYSA-N 19024 1-[3-(aminomethyl)phenyl]-N-[4-(2-methanesulfonylphenyl)cyclohex-3-en-1-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::DPC 423 derivative, 4 Coagulation factor X Homo sapiens 3.0 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19024&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648140 46519073 ZINC14969526 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33985 CS(=O)(=O)c1ccccc1[C@H]1CC[C@@H](CC1)NC(=O)c1cc(nn1-c1cccc(CN)c1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-36(34,35)22-8-3-2-7-20(22)17-9-11-18(12-10-17)30-24(33)21-14-23(25(26,27)28)31-32(21)19-6-4-5-16(13-19)15-29/h2-8,13-14,17-18H,9-12,15,29H2,1H3,(H,30,33)/t17-,18- WWXSXVGKOQSOQE-IYARVYRRSA-N 19025 1-[3-(aminomethyl)phenyl]-N-[4-(2-methanesulfonylphenyl)cyclohexyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::DPC 423 derivative, 5 Coagulation factor X Homo sapiens 5.7 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19025&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648141 46519074 ZINC14969530 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33986 CS(=O)(=O)c1ccccc1[C@@H]1CC[C@@H](CC1)NC(=O)c1cc(nn1-c1cccc(CN)c1)C(F)(F)F InChI=1S/C25H27F3N4O3S/c1-36(34,35)22-8-3-2-7-20(22)17-9-11-18(12-10-17)30-24(33)21-14-23(25(26,27)28)31-32(21)19-6-4-5-16(13-19)15-29/h2-8,13-14,17-18H,9-12,15,29H2,1H3,(H,30,33)/t17-,18+ WWXSXVGKOQSOQE-HDICACEKSA-N 19026 1-[3-(aminomethyl)phenyl]-N-[4-(2-methanesulfonylphenyl)cyclohexyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::DPC 423 derivative, 6 Coagulation factor X Homo sapiens 2000 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19026&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648141 46519075 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33987 CS(=O)(=O)c1ccccc1N1CCC(CC1)NC(=O)c1cc(nn1-c1cccc(CN)c1)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-36(34,35)21-8-3-2-7-19(21)31-11-9-17(10-12-31)29-23(33)20-14-22(24(25,26)27)30-32(20)18-6-4-5-16(13-18)15-28/h2-8,13-14,17H,9-12,15,28H2,1H3,(H,29,33) FTPSVXUIIJXBJT-UHFFFAOYSA-N 19027 1-[3-(aminomethyl)phenyl]-N-[1-(2-methanesulfonylphenyl)piperidin-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::DPC 423 derivative, 7 Coagulation factor X Homo sapiens 4.9 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19027&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648142 46519076 ZINC14969532 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33988 CS(=O)(=O)c1ccccc1N1CCC(CC1)NC(=O)c1cc(nn1-c1ccccc1CN)C(F)(F)F InChI=1S/C24H26F3N5O3S/c1-36(34,35)21-9-5-4-8-19(21)31-12-10-17(11-13-31)29-23(33)20-14-22(24(25,26)27)30-32(20)18-7-3-2-6-16(18)15-28/h2-9,14,17H,10-13,15,28H2,1H3,(H,29,33) WDSKYLNBSGAMDR-UHFFFAOYSA-N 19028 1-[2-(aminomethyl)phenyl]-N-[1-(2-methanesulfonylphenyl)piperidin-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::DPC 423 derivative, 8 Coagulation factor X Homo sapiens 2.4 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19028&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648143 46519077 ZINC14969536 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33989 CS(=O)(=O)c1ccccc1N1CCC(CC1)NC(=O)c1cc(nn1-c1ccc2onc(N)c2c1)C(F)(F)F InChI=1S/C24H23F3N6O4S/c1-38(35,36)20-5-3-2-4-17(20)32-10-8-14(9-11-32)29-23(34)18-13-21(24(25,26)27)30-33(18)15-6-7-19-16(12-15)22(28)31-37-19/h2-7,12-14H,8-11H2,1H3,(H2,28,31)(H,29,34) HADDJWUKDPCVQU-UHFFFAOYSA-N 19029 1-(3-amino-1,2-benzoxazol-5-yl)-N-[1-(2-methanesulfonylphenyl)piperidin-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::DPC 423 derivative, 9a Coagulation factor X Homo sapiens 1.7 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19029&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648144 46519078 ZINC14969540 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33990 CS(=O)(=O)c1ccccc1N1CCC(CC1=O)NC(=O)c1cc(nn1-c1ccc2onc(N)c2c1)C(F)(F)F InChI=1S/C24H21F3N6O5S/c1-39(36,37)19-5-3-2-4-16(19)32-9-8-13(10-21(32)34)29-23(35)17-12-20(24(25,26)27)30-33(17)14-6-7-18-15(11-14)22(28)31-38-18/h2-7,11-13H,8-10H2,1H3,(H2,28,31)(H,29,35) PCXZXBSEQRZTCV-UHFFFAOYSA-N 19030 1-(3-amino-1,2-benzoxazol-5-yl)-N-[1-(2-methanesulfonylphenyl)-2-oxopiperidin-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::DPC 423 derivative, 10 Coagulation factor X Homo sapiens 92 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19030&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648145 46519079 ZINC14969548 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33991 COc1ccc(cc1)-n1nc(cc1C(=O)NC1CCN(CC1)c1ccccc1S(C)(=O)=O)C(F)(F)F InChI=1S/C24H25F3N4O4S/c1-35-18-9-7-17(8-10-18)31-20(15-22(29-31)24(25,26)27)23(32)28-16-11-13-30(14-12-16)19-5-3-4-6-21(19)36(2,33)34/h3-10,15-16H,11-14H2,1-2H3,(H,28,32) MJEWRMPWUXPMDB-UHFFFAOYSA-N 19031 DPC 423 derivative, 11a::N-[1-(2-methanesulfonylphenyl)piperidin-4-yl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide Coagulation factor X Homo sapiens 14 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19031&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648146 46519080 ZINC14969552 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33992 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)NC1CCN(CC1)c1ccccc1CN1CCCC1)C(F)(F)F InChI=1S/C28H30F3N7O2/c29-28(30,31)25-16-23(38(34-25)20-7-8-24-21(15-20)26(32)35-40-24)27(39)33-19-9-13-37(14-10-19)22-6-2-1-5-18(22)17-36-11-3-4-12-36/h1-2,5-8,15-16,19H,3-4,9-14,17H2,(H2,32,35)(H,33,39) PSPGVVDGXOYNRQ-UHFFFAOYSA-N 19032 1-(3-amino-1,2-benzoxazol-5-yl)-N-{1-[2-(pyrrolidin-1-ylmethyl)phenyl]piperidin-4-yl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 9b Coagulation factor X Homo sapiens 0.61 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19032&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648147 46519081 ZINC14969556 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33993 Nc1noc2ccc(cc12)-n1nc(cc1C(=O)NC1CCN(CC1)c1ccccc1CN1CCC[C@H]1O)C(F)(F)F InChI=1S/C28H30F3N7O3/c29-28(30,31)24-15-22(38(34-24)19-7-8-23-20(14-19)26(32)35-41-23)27(40)33-18-9-12-36(13-10-18)21-5-2-1-4-17(21)16-37-11-3-6-25(37)39/h1-2,4-5,7-8,14-15,18,25,39H,3,6,9-13,16H2,(H2,32,35)(H,33,40)/t25-/m1/s1 IYCGPDFYFRTXIV-RUZDIDTESA-N 19033 1-(3-amino-1,2-benzoxazol-5-yl)-N-[1-(2-{[(2R)-2-hydroxypyrrolidin-1-yl]methyl}phenyl)piperidin-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 9c Coagulation factor X Homo sapiens 0.73 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19033&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648148 46519082 ZINC14969560 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33994 CNCc1ccccc1N1CCC(CC1)NC(=O)c1cc(nn1-c1ccc2onc(N)c2c1)C(F)(F)F InChI=1S/C25H26F3N7O2/c1-30-14-15-4-2-3-5-19(15)34-10-8-16(9-11-34)31-24(36)20-13-22(25(26,27)28)32-35(20)17-6-7-21-18(12-17)23(29)33-37-21/h2-7,12-13,16,30H,8-11,14H2,1H3,(H2,29,33)(H,31,36) JNNNQOVXXHMSBM-UHFFFAOYSA-N 19034 1-(3-amino-1,2-benzoxazol-5-yl)-N-(1-{2-[(methylamino)methyl]phenyl}piperidin-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 9d Coagulation factor X Homo sapiens 0.67 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19034&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648149 46519083 ZINC14969565 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33995 CCN(C)Cc1ccccc1N1CCC(CC1)NC(=O)c1cc(nn1-c1ccc2onc(N)c2c1)C(F)(F)F InChI=1S/C27H30F3N7O2/c1-3-35(2)16-17-6-4-5-7-21(17)36-12-10-18(11-13-36)32-26(38)22-15-24(27(28,29)30)33-37(22)19-8-9-23-20(14-19)25(31)34-39-23/h4-9,14-15,18H,3,10-13,16H2,1-2H3,(H2,31,34)(H,32,38) AKDHCBCCGAELNG-UHFFFAOYSA-N 19035 1-(3-amino-1,2-benzoxazol-5-yl)-N-[1-(2-{[ethyl(methyl)amino]methyl}phenyl)piperidin-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 9e Coagulation factor X Homo sapiens 0.7 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19035&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648150 46519084 ZINC14969569 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33996 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)c3ccccc3S(C)(=O)=O)C(=O)c12 InChI=1S/C26H29N5O5S/c1-36-19-9-7-18(8-10-19)31-24-20(23(28-31)25(27)32)13-16-30(26(24)33)17-11-14-29(15-12-17)21-5-3-4-6-22(21)37(2,34)35/h3-10,17H,11-16H2,1-2H3,(H2,27,32) PJHHSGILIGVDLH-UHFFFAOYSA-N 19036 6-[1-(2-methanesulfonylphenyl)piperidin-4-yl]-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 16a Coagulation factor X Homo sapiens 0.35 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19036&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16664096 46519085 ZINC11686192 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33997 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)c3ccccc3CN(C)C)C(=O)c12 InChI=1S/C28H34N6O3/c1-31(2)18-19-6-4-5-7-24(19)32-15-12-20(13-16-32)33-17-14-23-25(27(29)35)30-34(26(23)28(33)36)21-8-10-22(37-3)11-9-21/h4-11,20H,12-18H2,1-3H3,(H2,29,35) QLIJAYGAJCPYAJ-UHFFFAOYSA-N 19037 6-(1-{2-[(dimethylamino)methyl]phenyl}piperidin-4-yl)-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 16b Coagulation factor X Homo sapiens 0.41 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19037&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648151 46519086 ZINC14969573 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33998 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)c3ccccc3CN3CCCC3)C(=O)c12 InChI=1S/C30H36N6O3/c1-39-24-10-8-23(9-11-24)36-28-25(27(32-36)29(31)37)14-19-35(30(28)38)22-12-17-34(18-13-22)26-7-3-2-6-21(26)20-33-15-4-5-16-33/h2-3,6-11,22H,4-5,12-20H2,1H3,(H2,31,37) DPXWCKIVLONPSP-UHFFFAOYSA-N 19038 1-(4-methoxyphenyl)-7-oxo-6-{1-[2-(pyrrolidin-1-ylmethyl)phenyl]piperidin-4-yl}-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 16c Coagulation factor X Homo sapiens 0.26 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19038&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648152 46519087 ZINC14969577 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 33999 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)c3ccccc3CN3CCOCC3)C(=O)c12 InChI=1S/C30H36N6O4/c1-39-24-8-6-23(7-9-24)36-28-25(27(32-36)29(31)37)12-15-35(30(28)38)22-10-13-34(14-11-22)26-5-3-2-4-21(26)20-33-16-18-40-19-17-33/h2-9,22H,10-20H2,1H3,(H2,31,37) HPKMQHKNHYQOFE-UHFFFAOYSA-N 19039 1-(4-methoxyphenyl)-6-{1-[2-(morpholin-4-ylmethyl)phenyl]piperidin-4-yl}-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 16d Coagulation factor X Homo sapiens 0.57 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19039&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648153 46519088 ZINC14969581 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 34000 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)c3ccccc3CN3CCC[C@@H]3O)C(=O)c12 InChI=1S/C30H36N6O4/c1-40-23-10-8-22(9-11-23)36-28-24(27(32-36)29(31)38)14-18-35(30(28)39)21-12-16-33(17-13-21)25-6-3-2-5-20(25)19-34-15-4-7-26(34)37/h2-3,5-6,8-11,21,26,37H,4,7,12-19H2,1H3,(H2,31,38)/t26-/m0/s1 LJAOENIQJNXLHY-SANMLTNESA-N 19040 6-[1-(2-{[(2S)-2-hydroxypyrrolidin-1-yl]methyl}phenyl)piperidin-4-yl]-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 16e Coagulation factor X Homo sapiens 0.87 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19040&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648154 46519089 ZINC14969585 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 34001 CNCc1ccccc1N1CCC(CC1)N1CCc2c(nn(c2C1=O)-c1ccc(OC)cc1)C(N)=O InChI=1S/C27H32N6O3/c1-29-17-18-5-3-4-6-23(18)31-14-11-19(12-15-31)32-16-13-22-24(26(28)34)30-33(25(22)27(32)35)20-7-9-21(36-2)10-8-20/h3-10,19,29H,11-17H2,1-2H3,(H2,28,34) YNFFFTKJHNMRSM-UHFFFAOYSA-N 19041 1-(4-methoxyphenyl)-6-(1-{2-[(methylamino)methyl]phenyl}piperidin-4-yl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 16f Coagulation factor X Homo sapiens 1.0 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19041&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22318549 46519090 ZINC14969589 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 34002 CCN(CC)Cc1ccccc1N1CCC(CC1)N1CCc2c(nn(c2C1=O)-c1ccc(OC)cc1)C(N)=O InChI=1S/C30H38N6O3/c1-4-33(5-2)20-21-8-6-7-9-26(21)34-17-14-22(15-18-34)35-19-16-25-27(29(31)37)32-36(28(25)30(35)38)23-10-12-24(39-3)13-11-23/h6-13,22H,4-5,14-20H2,1-3H3,(H2,31,37) ITHCVPPZUXPRGP-UHFFFAOYSA-N 19042 6-(1-{2-[(diethylamino)methyl]phenyl}piperidin-4-yl)-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 16g Coagulation factor X Homo sapiens 0.26 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19042&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648155 46519091 ZINC14969593 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 34003 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)c3ccccc3CN(C)C(C)=O)C(=O)c12 InChI=1S/C29H34N6O4/c1-19(36)32(2)18-20-6-4-5-7-25(20)33-15-12-21(13-16-33)34-17-14-24-26(28(30)37)31-35(27(24)29(34)38)22-8-10-23(39-3)11-9-22/h4-11,21H,12-18H2,1-3H3,(H2,30,37) UVYVJQFOXZDFLB-UHFFFAOYSA-N 19043 1-(4-methoxyphenyl)-6-(1-{2-[(N-methylacetamido)methyl]phenyl}piperidin-4-yl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 16h Coagulation factor X Homo sapiens 23 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19043&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22318550 46519092 ZINC14969596 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 34004 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)c3ccccc3CN(C)S(C)(=O)=O)C(=O)c12 InChI=1S/C28H34N6O5S/c1-31(40(3,37)38)18-19-6-4-5-7-24(19)32-15-12-20(13-16-32)33-17-14-23-25(27(29)35)30-34(26(23)28(33)36)21-8-10-22(39-2)11-9-21/h4-11,20H,12-18H2,1-3H3,(H2,29,35) RYZNSPLDPMGHBQ-UHFFFAOYSA-N 19044 6-[1-(2-{[methane(methyl)sulfonamido]methyl}phenyl)piperidin-4-yl]-1-(4-methoxyphenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 16i Coagulation factor X Homo sapiens 81 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19044&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10196628 46519093 ZINC14969600 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 34005 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)c3ccccc3S(N)(=O)=O)C(=O)c12 InChI=1S/C25H28N6O5S/c1-36-18-8-6-17(7-9-18)31-23-19(22(28-31)24(26)32)12-15-30(25(23)33)16-10-13-29(14-11-16)20-4-2-3-5-21(20)37(27,34)35/h2-9,16H,10-15H2,1H3,(H2,26,32)(H2,27,34,35) YJUJJFRSUPPGHE-UHFFFAOYSA-N 19045 1-(4-methoxyphenyl)-7-oxo-6-[1-(2-sulfamoylphenyl)piperidin-4-yl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 16j Coagulation factor X Homo sapiens 3.9 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19045&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648156 46519094 ZINC14969604 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 34006 COc1ccc(cc1)-n1nc(cc1C(=O)NC1CCN(CC1)c1ccccc1CN(C)C)C(F)(F)F InChI=1S/C26H30F3N5O2/c1-32(2)17-18-6-4-5-7-22(18)33-14-12-19(13-15-33)30-25(35)23-16-24(26(27,28)29)31-34(23)20-8-10-21(36-3)11-9-20/h4-11,16,19H,12-15,17H2,1-3H3,(H,30,35) HGTRHZWAYWVDSC-UHFFFAOYSA-N 19046 N-(1-{2-[(dimethylamino)methyl]phenyl}piperidin-4-yl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 11b Coagulation factor X Homo sapiens 8.8 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19046&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648157 46519095 ZINC14969608 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 34007 COc1ccc(cc1)-n1nc(cc1C(=O)NC1CCN(CC1)c1ccccc1CN1CCCC1)C(F)(F)F InChI=1S/C28H32F3N5O2/c1-38-23-10-8-22(9-11-23)36-25(18-26(33-36)28(29,30)31)27(37)32-21-12-16-35(17-13-21)24-7-3-2-6-20(24)19-34-14-4-5-15-34/h2-3,6-11,18,21H,4-5,12-17,19H2,1H3,(H,32,37) DIWCSTDCMYQMNO-UHFFFAOYSA-N 19047 1-(4-methoxyphenyl)-N-{1-[2-(pyrrolidin-1-ylmethyl)phenyl]piperidin-4-yl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 11c Coagulation factor X Homo sapiens 29 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19047&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648158 46519096 ZINC14969612 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 34008 COc1ccc(cc1)-n1nc(cc1C(=O)NC1CCN(CC1)c1ccccc1CN1CCOCC1)C(F)(F)F InChI=1S/C28H32F3N5O3/c1-38-23-8-6-22(7-9-23)36-25(18-26(33-36)28(29,30)31)27(37)32-21-10-12-35(13-11-21)24-5-3-2-4-20(24)19-34-14-16-39-17-15-34/h2-9,18,21H,10-17,19H2,1H3,(H,32,37) GEZSGMSCSMDRCW-UHFFFAOYSA-N 19048 1-(4-methoxyphenyl)-N-{1-[2-(morpholin-4-ylmethyl)phenyl]piperidin-4-yl}-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::Pyrazole-based inhibitor containing N-arylpiperidiny, 11d Coagulation factor X Homo sapiens 6.6 7 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.11.071 10.7270/Q2KD1W5D 17174550 aid1797814 Qiao, JX; Cheng, X; Smallheer, JM; Galemmo, RA; Drummond, S; Pinto, DJ; Cheney, DL; He, K; Wong, PC; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19048&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23648159 46519097 ZINC14969617 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42713 Cc1ccc2oc(=O)c(cc2c1)C(=O)Nc1cc(C)cc(C)c1 InChI=1S/C19H17NO3/c1-11-4-5-17-14(7-11)10-16(19(22)23-17)18(21)20-15-8-12(2)6-13(3)9-15/h4-10H,1-3H3,(H,20,21) LQLUAXVECOARTB-UHFFFAOYSA-N 23564 3-Carboxamide-coumarin deriv., 34::N-(3,5-dimethylphenyl)-6-methyl-2-oxo-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23564&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860448 50091825 ZINC40955680 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42714 Clc1cc(Cl)c2oc(=O)c(cc2c1)C(=O)Nc1ccccc1 InChI=1S/C16H9Cl2NO3/c17-10-6-9-7-12(16(21)22-14(9)13(18)8-10)15(20)19-11-4-2-1-3-5-11/h1-8H,(H,19,20) RCCAMTUJQYPMED-UHFFFAOYSA-N 23547 3-Carboxamide-coumarin deriv., 41::6,8-dichloro-2-oxo-N-phenyl-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23547&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 741761 50091808 ZINC00180530 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42715 Cc1cccc(NC(=O)c2cc3cc(Cl)cc(Cl)c3oc2=O)c1 InChI=1S/C17H11Cl2NO3/c1-9-3-2-4-12(5-9)20-16(21)13-7-10-6-11(18)8-14(19)15(10)23-17(13)22/h2-8H,1H3,(H,20,21) SONVRVRNPLMRNE-UHFFFAOYSA-N 23565 3-Carboxamide-coumarin deriv., 42::6,8-dichloro-N-(3-methylphenyl)-2-oxo-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23565&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 3753834 50091826 ZINC00192848 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42716 Cc1cc(C)cc(NC(=O)c2cc3cc(Cl)cc(Cl)c3oc2=O)c1 InChI=1S/C18H13Cl2NO3/c1-9-3-10(2)5-13(4-9)21-17(22)14-7-11-6-12(19)8-15(20)16(11)24-18(14)23/h3-8H,1-2H3,(H,21,22) OGDFRBNWXDWIQT-UHFFFAOYSA-N 23566 3-Carboxamide-coumarin deriv., 43::6,8-dichloro-N-(3,5-dimethylphenyl)-2-oxo-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens >50000 Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23566&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860449 50091827 ZINC26843164 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42717 Clc1cc(Br)c2oc(=O)c(cc2c1)C(=O)Nc1ccccc1 InChI=1S/C16H9BrClNO3/c17-13-8-10(18)6-9-7-12(16(21)22-14(9)13)15(20)19-11-4-2-1-3-5-11/h1-8H,(H,19,20) IUBMSLQOIUSAFA-UHFFFAOYSA-N 23548 3-Carboxamide-coumarin deriv., 44::8-bromo-6-chloro-2-oxo-N-phenyl-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23548&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860440 50091809 ZINC40429502 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42718 Cc1cccc(NC(=O)c2cc3cc(Cl)cc(Br)c3oc2=O)c1 InChI=1S/C17H11BrClNO3/c1-9-3-2-4-12(5-9)20-16(21)13-7-10-6-11(19)8-14(18)15(10)23-17(13)22/h2-8H,1H3,(H,20,21) AOZYTCBDNDDZPR-UHFFFAOYSA-N 23567 3-Carboxamide-coumarin deriv., 45::8-bromo-6-chloro-N-(3-methylphenyl)-2-oxo-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23567&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860450 50091828 ZINC40972363 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42719 Cc1cc(C)cc(NC(=O)c2cc3cc(Cl)cc(Br)c3oc2=O)c1 InChI=1S/C18H13BrClNO3/c1-9-3-10(2)5-13(4-9)21-17(22)14-7-11-6-12(20)8-15(19)16(11)24-18(14)23/h3-8H,1-2H3,(H,21,22) NIYAHNDDVVFHBG-UHFFFAOYSA-N 23568 3-Carboxamide-coumarin deriv., 46::8-bromo-6-chloro-N-(3,5-dimethylphenyl)-2-oxo-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens >50000 Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23568&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860451 50091829 ZINC40972365 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42720 NC(N)=NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCN1)C(=O)CCl InChI=1S/C21H31ClN6O3/c22-13-18(29)15(8-4-11-26-21(23)24)27-20(31)17(12-14-6-2-1-3-7-14)28-19(30)16-9-5-10-25-16/h1-3,6-7,15-17,25H,4-5,8-13H2,(H,27,31)(H,28,30)(H4,23,24,26)/t15-,16+,17-/m0/s1 HCCRRLVJBLDSLL-BBWFWOEESA-N 23569 (2S)-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]-3-phenyl-2-[(2R)-pyrrolidin-2-ylformamido]propanamide::D-Pro-Phe-Arg chloromethyl ketone (PCK) Coagulation factor X Homo sapiens 1900 Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23569&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10456438 50091830 ZINC13507825 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42755 Cc1ccc2oc(=O)c(cc2c1)C(=O)NC1CCCCCCCCCCC1 InChI=1S/C23H31NO3/c1-17-13-14-21-18(15-17)16-20(23(26)27-21)22(25)24-19-11-9-7-5-3-2-4-6-8-10-12-19/h13-16,19H,2-12H2,1H3,(H,24,25) VWQOVCCGOGWSCR-UHFFFAOYSA-N 23536 3-Carboxamide-coumarin deriv., 22::N-cyclododecyl-6-methyl-2-oxo-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23536&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860434 50091797 ZINC40955744 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42756 Cc1ccc2oc(=O)c(cc2c1)C(=O)NC12CC3CC(CC(C3)C1)C2 InChI=1S/C21H23NO3/c1-12-2-3-18-16(4-12)8-17(20(24)25-18)19(23)22-21-9-13-5-14(10-21)7-15(6-13)11-21/h2-4,8,13-15H,5-7,9-11H2,1H3,(H,22,23) GNLDGWVBEXHJII-UHFFFAOYSA-N 23537 3-Carboxamide-coumarin deriv., 23::N-(adamantan-1-yl)-6-methyl-2-oxo-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23537&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860435 50091798 ZINC40955747 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42757 Cc1ccc2oc(=O)c(cc2c1)C(=O)Nc1ccccc1 InChI=1S/C17H13NO3/c1-11-7-8-15-12(9-11)10-14(17(20)21-15)16(19)18-13-5-3-2-4-6-13/h2-10H,1H3,(H,18,19) JUQDUATUBQVGDN-UHFFFAOYSA-N 23538 3-Carboxamide-coumarin deriv., 20::6-methyl-2-oxo-N-phenyl-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23538&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10423722 50091799 ZINC38816294 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42758 Cc1ccc2oc(=O)c(cc2c1)C(=O)NCc1ccccc1 InChI=1S/C18H15NO3/c1-12-7-8-16-14(9-12)10-15(18(21)22-16)17(20)19-11-13-5-3-2-4-6-13/h2-10H,11H2,1H3,(H,19,20) ZEYLUFWPGDCIRE-UHFFFAOYSA-N 23539 3-Carboxamide-coumarin deriv., 24::N-benzyl-6-methyl-2-oxo-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23539&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860436 50091800 ZINC40955750 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42759 Cc1ccc2oc(=O)c(cc2c1)C(=O)NCCc1ccccc1 InChI=1S/C19H17NO3/c1-13-7-8-17-15(11-13)12-16(19(22)23-17)18(21)20-10-9-14-5-3-2-4-6-14/h2-8,11-12H,9-10H2,1H3,(H,20,21) AOIFLQZKMIKPNH-UHFFFAOYSA-N 23540 3-Carboxamide-coumarin deriv., 25::6-methyl-2-oxo-N-(2-phenylethyl)-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23540&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860437 50091801 ZINC40431329 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42760 Cc1ccc2oc(=O)c(cc2c1)C(=O)NCc1cccc2ccccc12 InChI=1S/C22H17NO3/c1-14-9-10-20-17(11-14)12-19(22(25)26-20)21(24)23-13-16-7-4-6-15-5-2-3-8-18(15)16/h2-12H,13H2,1H3,(H,23,24) AVGJZESYBKYYGZ-UHFFFAOYSA-N 23541 3-Carboxamide-coumarin deriv., 26::6-methyl-N-(naphthalen-1-ylmethyl)-2-oxo-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23541&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860438 50091802 ZINC40430494 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42761 Cc1ccc2oc(=O)c(cc2c1)C(=O)Nc1cnc2ccccc2c1 InChI=1S/C20H14N2O3/c1-12-6-7-18-14(8-12)10-16(20(24)25-18)19(23)22-15-9-13-4-2-3-5-17(13)21-11-15/h2-11H,1H3,(H,22,23) VZCIAGCETBUMJW-UHFFFAOYSA-N 23542 3-Carboxamide-coumarin deriv., 27::6-methyl-2-oxo-N-(quinolin-3-yl)-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23542&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860439 50091803 ZINC40827710 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42762 O=C(Nc1ccccc1)c1cc2ccccc2oc1=O InChI=1S/C16H11NO3/c18-15(17-12-7-2-1-3-8-12)13-10-11-6-4-5-9-14(11)20-16(13)19/h1-10H,(H,17,18) IMFBGZCBLOPVCJ-UHFFFAOYSA-N 23543 2-oxo-N-phenyl-2H-chromene-3-carboxamide::3-Carboxamide-coumarin deriv., 18::JMC521935 Compound 6 Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23543&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 341782 50091804 ZINC00042178 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42763 ClCc1ccc2oc(=O)c(cc2c1)C(=O)Nc1ccccc1 InChI=1S/C17H12ClNO3/c18-10-11-6-7-15-12(8-11)9-14(17(21)22-15)16(20)19-13-4-2-1-3-5-13/h1-9H,10H2,(H,19,20) RUYAFFMOCORBIV-UHFFFAOYSA-N 23544 3-Carboxamide-coumarin deriv., 4::6-(chloromethyl)-2-oxo-N-phenyl-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens >50000 Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23544&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 402501 50091805 ZINC01660778 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42764 [O-][N+](=O)c1ccc2oc(=O)c(cc2c1)C(=O)Nc1ccccc1 InChI=1S/C16H10N2O5/c19-15(17-11-4-2-1-3-5-11)13-9-10-8-12(18(21)22)6-7-14(10)23-16(13)20/h1-9H,(H,17,19) NDMMIVPXGAPYKM-UHFFFAOYSA-N 23545 3-Carboxamide-coumarin deriv., 35::6-nitro-2-oxo-N-phenyl-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23545&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 739350 50091806 ZINC00174967 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42765 Brc1ccc2oc(=O)c(cc2c1)C(=O)Nc1ccccc1 InChI=1S/C16H10BrNO3/c17-11-6-7-14-10(8-11)9-13(16(20)21-14)15(19)18-12-4-2-1-3-5-12/h1-9H,(H,18,19) PNVSYOXGZZSDQM-UHFFFAOYSA-N 23546 3-Carboxamide-coumarin deriv., 36::6-bromo-2-oxo-N-phenyl-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23546&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 747661 50091807 ZINC00192816 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42768 COc1cc(Br)cc2cc(C(=O)Nc3ccccc3)c(=O)oc12 InChI=1S/C17H12BrNO4/c1-22-14-9-11(18)7-10-8-13(17(21)23-15(10)14)16(20)19-12-5-3-2-4-6-12/h2-9H,1H3,(H,19,20) LIBPMSGKTCOWCM-UHFFFAOYSA-N 23549 3-Carboxamide-coumarin deriv., 47::6-bromo-8-methoxy-2-oxo-N-phenyl-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23549&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860441 50091810 ZINC26842740 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42769 ClCc1ccc2oc(=O)c(cc2c1)C(=O)Oc1ccccc1 InChI=1S/C17H11ClO4/c18-10-11-6-7-15-12(8-11)9-14(17(20)22-15)16(19)21-13-4-2-1-3-5-13/h1-9H,10H2 VLAVQNSKKDLVGI-UHFFFAOYSA-N 23563 3-Carboxylate-coumarin deriv., 3::CHEMBL13357::phenyl 6-(chloromethyl)-2-oxo-2H-chromene-3-carboxylate Coagulation factor X Homo sapiens >50000 Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23563&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 402499 50091824 CHEMBL13357 ZINC01660776 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42770 Cc1ccc2oc(=O)c(cc2c1)C(=O)Nc1ccccc1Cl InChI=1S/C17H12ClNO3/c1-10-6-7-15-11(8-10)9-12(17(21)22-15)16(20)19-14-5-3-2-4-13(14)18/h2-9H,1H3,(H,19,20) FPUSGBFAZGKFJK-UHFFFAOYSA-N 23555 3-Carboxamide-coumarin deriv., 31::N-(2-chlorophenyl)-6-methyl-2-oxo-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23555&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860442 50091816 ZINC40953963 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42771 Cc1ccc2oc(=O)c(cc2c1)C(=O)Nc1cccc(Cl)c1 InChI=1S/C17H12ClNO3/c1-10-5-6-15-11(7-10)8-14(17(21)22-15)16(20)19-13-4-2-3-12(18)9-13/h2-9H,1H3,(H,19,20) OOLBPPCJUQNAAW-UHFFFAOYSA-N 23556 3-Carboxamide-coumarin deriv., 32::N-(3-chlorophenyl)-6-methyl-2-oxo-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23556&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860443 50091817 ZINC40431165 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42772 Cc1ccc2oc(=O)c(cc2c1)C(=O)Nc1ccc(Cl)cc1 InChI=1S/C17H12ClNO3/c1-10-2-7-15-11(8-10)9-14(17(21)22-15)16(20)19-13-5-3-12(18)4-6-13/h2-9H,1H3,(H,19,20) KLSTVAQJRQHMEW-UHFFFAOYSA-N 23557 3-Carboxamide-coumarin deriv., 33::N-(4-chlorophenyl)-6-methyl-2-oxo-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23557&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860444 50091818 ZINC40954603 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42773 Cc1ccc2oc(=O)c(cc2c1)C(=O)Nc1ccccc1C InChI=1S/C18H15NO3/c1-11-7-8-16-13(9-11)10-14(18(21)22-16)17(20)19-15-6-4-3-5-12(15)2/h3-10H,1-2H3,(H,19,20) FCSXWWMASMRVEL-UHFFFAOYSA-N 23558 3-Carboxamide-coumarin deriv., 28::6-methyl-N-(2-methylphenyl)-2-oxo-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23558&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860445 50091819 ZINC40424127 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42774 Cc1cccc(NC(=O)c2cc3cc(C)ccc3oc2=O)c1 InChI=1S/C18H15NO3/c1-11-4-3-5-14(9-11)19-17(20)15-10-13-8-12(2)6-7-16(13)22-18(15)21/h3-10H,1-2H3,(H,19,20) BYMDGQZMHMAQIC-UHFFFAOYSA-N 23559 3-Carboxamide-coumarin deriv., 29::6-methyl-N-(3-methylphenyl)-2-oxo-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23559&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860446 50091820 ZINC40431053 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 42775 Cc1ccc(NC(=O)c2cc3cc(C)ccc3oc2=O)cc1 InChI=1S/C18H15NO3/c1-11-3-6-14(7-4-11)19-17(20)15-10-13-9-12(2)5-8-16(13)22-18(15)21/h3-10H,1-2H3,(H,19,20) MFUWDBLYKLNULI-UHFFFAOYSA-N 23560 3-Carboxamide-coumarin deriv., 30::6-methyl-N-(4-methylphenyl)-2-oxo-2H-chromene-3-carboxamide Coagulation factor X Homo sapiens Curated from the literature by BindingDB 10.1021/jm8002697 10.7270/Q2610XNH 18459730 aid1798332 Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L University of Namur http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23560&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 24860447 50091821 ZINC40955216 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 48039 Cc1cccc(NC(=S)N[C@H]2CCCCN(CC(=O)N3CCCC3)C2=O)c1 InChI=1S/C20H28N4O2S/c1-15-7-6-8-16(13-15)21-20(27)22-17-9-2-3-12-24(19(17)26)14-18(25)23-10-4-5-11-23/h6-8,13,17H,2-5,9-12,14H2,1H3,(H2,21,22,27)/t17-/m0/s1 ROBFJTHBLVFFRU-KRWDZBQOSA-N 26350 (S)-1-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-yl)-3-m-tolylthiourea::1-(3-methylphenyl)-3-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]thiourea::3-(3-methylphenyl)-1-[(3S)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepan-3-yl]thiourea::3-methylphenyl compound, 1::BMCL196882 Compound 1::CHEMBL198694 Coagulation factor X Homo sapiens 110 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm800855x 10.7270/Q2V12332 18998662 aid1798672 Shi, Y; Sitkoff, D; Zhang, J; Klei, HE; Kish, K; Liu, EC; Hartl, KS; Seiler, SM; Chang, M; Huang, C; Youssef, S; Steinbacher, TE; Schumacher, WA; Grazier, N; Pudzianowski, A; Apedo, A; Discenza, L; Yanchunas, J; Stein, PD; Atwal, KS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26350&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 25138134 56464787 CHEMBL198694 ZINC28530127 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 48040 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)C(C#N)C#N InChI=1S/C25H28N6O3/c1-17-12-18-13-20(7-8-22(18)34-17)28-24(19(14-26)15-27)29-21-6-2-3-11-31(25(21)33)16-23(32)30-9-4-5-10-30/h7-8,12-13,19,21H,2-6,9-11,16H2,1H3,(H,28,29)/t21-/m0/s1 HKKVYLLIDWPQMA-NRFANRHFSA-N 26351 2-methylbenzofuran compound, 2::2-{[(2-methyl-1-benzofuran-5-yl)amino]({[(3S)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepan-3-yl]amino})methylidene}propanedinitrile::CHEMBL196803 Coagulation factor X Homo sapiens 30 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm800855x 10.7270/Q2V12332 18998662 aid1798672 Shi, Y; Sitkoff, D; Zhang, J; Klei, HE; Kish, K; Liu, EC; Hartl, KS; Seiler, SM; Chang, M; Huang, C; Youssef, S; Steinbacher, TE; Schumacher, WA; Grazier, N; Pudzianowski, A; Apedo, A; Discenza, L; Yanchunas, J; Stein, PD; Atwal, KS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26351&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91242797 56464788 CHEMBL196803 ZINC34689203 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 48041 Cc1c[nH]c2c(cccc12)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)C(C#N)C#N InChI=1S/C25H29N7O2/c1-17-15-28-23-19(17)7-6-9-20(23)29-24(18(13-26)14-27)30-21-8-2-3-12-32(25(21)34)16-22(33)31-10-4-5-11-31/h6-7,9,15,18,21,28H,2-5,8,10-12,16H2,1H3,(H,29,30)/t21-/m0/s1 VPSKDLFTAXFXMT-NRFANRHFSA-N 26352 2-{[(3-methyl-1H-indol-7-yl)amino]({[(3S)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepan-3-yl]amino})methylidene}propanedinitrile::3-methylindole compound, 3 Coagulation factor X Homo sapiens 114 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm800855x 10.7270/Q2V12332 18998662 aid1798672 Shi, Y; Sitkoff, D; Zhang, J; Klei, HE; Kish, K; Liu, EC; Hartl, KS; Seiler, SM; Chang, M; Huang, C; Youssef, S; Steinbacher, TE; Schumacher, WA; Grazier, N; Pudzianowski, A; Apedo, A; Discenza, L; Yanchunas, J; Stein, PD; Atwal, KS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26352&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91254222 56464789 ZINC40393520 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 48042 O=C(CN1CCCC[C@H](NC(=Nc2cccc3cc[nH]c23)C(C#N)C#N)C1=O)N1CCCC1 InChI=1S/C24H27N7O2/c25-14-18(15-26)23(28-19-8-5-6-17-9-10-27-22(17)19)29-20-7-1-2-13-31(24(20)33)16-21(32)30-11-3-4-12-30/h5-6,8-10,18,20,27H,1-4,7,11-13,16H2,(H,28,29)/t20-/m0/s1 MWNQWXJZEKWVMI-FQEVSTJZSA-N 26353 2-[(1H-indol-7-ylamino)({[(3S)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepan-3-yl]amino})methylidene]propanedinitrile::indole-7-yl compound, 14 Coagulation factor X Homo sapiens 430 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm800855x 10.7270/Q2V12332 18998662 aid1798672 Shi, Y; Sitkoff, D; Zhang, J; Klei, HE; Kish, K; Liu, EC; Hartl, KS; Seiler, SM; Chang, M; Huang, C; Youssef, S; Steinbacher, TE; Schumacher, WA; Grazier, N; Pudzianowski, A; Apedo, A; Discenza, L; Yanchunas, J; Stein, PD; Atwal, KS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26353&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91255104 56464790 ZINC03955435 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 48043 Clc1c[nH]c2c(cccc12)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)C(C#N)C#N InChI=1S/C24H26ClN7O2/c25-18-14-28-22-17(18)6-5-8-19(22)29-23(16(12-26)13-27)30-20-7-1-2-11-32(24(20)34)15-21(33)31-9-3-4-10-31/h5-6,8,14,16,20,28H,1-4,7,9-11,15H2,(H,29,30)/t20-/m0/s1 NIZMINGTRGUPGY-FQEVSTJZSA-N 26354 2-{[(3-chloro-1H-indol-7-yl)amino]({[(3S)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepan-3-yl]amino})methylidene}propanedinitrile::3-chloroindole compound, 15 Coagulation factor X Homo sapiens 9.3 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm800855x 10.7270/Q2V12332 18998662 aid1798672 Shi, Y; Sitkoff, D; Zhang, J; Klei, HE; Kish, K; Liu, EC; Hartl, KS; Seiler, SM; Chang, M; Huang, C; Youssef, S; Steinbacher, TE; Schumacher, WA; Grazier, N; Pudzianowski, A; Apedo, A; Discenza, L; Yanchunas, J; Stein, PD; Atwal, KS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26354&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91236689 56464791 ZINC36413573 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 48044 COC(=O)C(C#N)C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1cccc2cc[nH]c12 InChI=1S/C25H30N6O4/c1-35-25(34)18(15-26)23(28-19-9-6-7-17-10-11-27-22(17)19)29-20-8-2-3-14-31(24(20)33)16-21(32)30-12-4-5-13-30/h6-7,9-11,18,20,27H,2-5,8,12-14,16H2,1H3,(H,28,29)/t18?,20-/m0/s1 ORAZILGZAILGDL-IJHRGXPZSA-N 26355 indole-7-yl compound, 16::methyl (2Z)-2-cyano-3-(1H-indol-7-ylamino)-3-{[(3S)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepan-3-yl]amino}prop-2-enoate Coagulation factor X Homo sapiens 650 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm800855x 10.7270/Q2V12332 18998662 aid1798672 Shi, Y; Sitkoff, D; Zhang, J; Klei, HE; Kish, K; Liu, EC; Hartl, KS; Seiler, SM; Chang, M; Huang, C; Youssef, S; Steinbacher, TE; Schumacher, WA; Grazier, N; Pudzianowski, A; Apedo, A; Discenza, L; Yanchunas, J; Stein, PD; Atwal, KS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26355&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91195333 56464792 51689 ZINC40848309 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 48045 COC(=O)C(C#N)C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1cccc2c[nH]nc12 InChI=1S/C24H29N7O4/c1-35-24(34)17(13-25)22(27-18-9-6-7-16-14-26-29-21(16)18)28-19-8-2-3-12-31(23(19)33)15-20(32)30-10-4-5-11-30/h6-7,9,14,17,19H,2-5,8,10-12,15H2,1H3,(H,26,29)(H,27,28)/t17?,19-/m0/s1 CIADMZOYTVAQSC-NNBQYGFHSA-N 26356 indazol-7-yl compound, 17::methyl (2Z)-2-cyano-3-(1H-indazol-7-ylamino)-3-{[(3S)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepan-3-yl]amino}prop-2-enoate Coagulation factor X Homo sapiens 13700 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm800855x 10.7270/Q2V12332 18998662 aid1798672 Shi, Y; Sitkoff, D; Zhang, J; Klei, HE; Kish, K; Liu, EC; Hartl, KS; Seiler, SM; Chang, M; Huang, C; Youssef, S; Steinbacher, TE; Schumacher, WA; Grazier, N; Pudzianowski, A; Apedo, A; Discenza, L; Yanchunas, J; Stein, PD; Atwal, KS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26356&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 90881152 56464793 51689 ZINC40393018 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 48046 COC(=O)C(C#N)C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1cccc2c(Cl)c[nH]c12 InChI=1S/C25H29ClN6O4/c1-36-25(35)17(13-27)23(29-19-9-6-7-16-18(26)14-28-22(16)19)30-20-8-2-3-12-32(24(20)34)15-21(33)31-10-4-5-11-31/h6-7,9,14,17,20,28H,2-5,8,10-12,15H2,1H3,(H,29,30)/t17?,20-/m0/s1 SKFZGPKSPUYPLJ-OZBJMMHXSA-N 26357 3-chloroindole compound, 18::methyl (2Z)-3-[(3-chloro-1H-indol-7-yl)amino]-2-cyano-3-{[(3S)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepan-3-yl]amino}prop-2-enoate Coagulation factor X Homo sapiens 8.9 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm800855x 10.7270/Q2V12332 18998662 aid1798672 Shi, Y; Sitkoff, D; Zhang, J; Klei, HE; Kish, K; Liu, EC; Hartl, KS; Seiler, SM; Chang, M; Huang, C; Youssef, S; Steinbacher, TE; Schumacher, WA; Grazier, N; Pudzianowski, A; Apedo, A; Discenza, L; Yanchunas, J; Stein, PD; Atwal, KS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26357&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 3ENS 90720065 56464794 51689 ZINC03955434 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 48047 CN(C)C(=O)C(C#N)C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1cccc2c(C)c[nH]c12 InChI=1S/C27H35N7O3/c1-18-16-29-24-19(18)9-8-11-21(24)30-25(20(15-28)26(36)32(2)3)31-22-10-4-5-14-34(27(22)37)17-23(35)33-12-6-7-13-33/h8-9,11,16,20,22,29H,4-7,10,12-14,17H2,1-3H3,(H,30,31)/t20?,22-/m0/s1 STEXSGQNONPPJY-IAXKEJLGSA-N 26358 (2Z)-2-cyano-N,N-dimethyl-3-[(3-methyl-1H-indol-7-yl)amino]-3-{[(3S)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepan-3-yl]amino}prop-2-enamide::3-methylindole compound, 19 Coagulation factor X Homo sapiens 118 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm800855x 10.7270/Q2V12332 18998662 aid1798672 Shi, Y; Sitkoff, D; Zhang, J; Klei, HE; Kish, K; Liu, EC; Hartl, KS; Seiler, SM; Chang, M; Huang, C; Youssef, S; Steinbacher, TE; Schumacher, WA; Grazier, N; Pudzianowski, A; Apedo, A; Discenza, L; Yanchunas, J; Stein, PD; Atwal, KS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26358&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91245026 56464795 51689 ZINC49808166 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 48048 CN(C)C(=O)C(C#N)C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1cccc2c(Cl)c[nH]c12 InChI=1S/C26H32ClN7O3/c1-32(2)25(36)18(14-28)24(30-20-10-7-8-17-19(27)15-29-23(17)20)31-21-9-3-4-13-34(26(21)37)16-22(35)33-11-5-6-12-33/h7-8,10,15,18,21,29H,3-6,9,11-13,16H2,1-2H3,(H,30,31)/t18?,21-/m0/s1 TZGZUYLAZYIPNS-ZYZRXSCRSA-N 26359 (2Z)-3-[(3-chloro-1H-indol-7-yl)amino]-2-cyano-N,N-dimethyl-3-{[(3S)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepan-3-yl]amino}prop-2-enamide::3-chloroindole compound, 20 Coagulation factor X Homo sapiens 2.4 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm800855x 10.7270/Q2V12332 18998662 aid1798672 Shi, Y; Sitkoff, D; Zhang, J; Klei, HE; Kish, K; Liu, EC; Hartl, KS; Seiler, SM; Chang, M; Huang, C; Youssef, S; Steinbacher, TE; Schumacher, WA; Grazier, N; Pudzianowski, A; Apedo, A; Discenza, L; Yanchunas, J; Stein, PD; Atwal, KS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26359&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91096682 56464796 51689 ZINC40379776 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 48049 CN(C)C(=O)C(C#N)C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1cccc2c(Br)c[nH]c12 InChI=1S/C26H32BrN7O3/c1-32(2)25(36)18(14-28)24(30-20-10-7-8-17-19(27)15-29-23(17)20)31-21-9-3-4-13-34(26(21)37)16-22(35)33-11-5-6-12-33/h7-8,10,15,18,21,29H,3-6,9,11-13,16H2,1-2H3,(H,30,31)/t18?,21-/m0/s1 WEZYQFYMKROKDT-ZYZRXSCRSA-N 26360 (2Z)-3-[(3-bromo-1H-indol-7-yl)amino]-2-cyano-N,N-dimethyl-3-{[(3S)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepan-3-yl]amino}prop-2-enamide::3-bromoindole compound, 21 Coagulation factor X Homo sapiens 9 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm800855x 10.7270/Q2V12332 18998662 aid1798672 Shi, Y; Sitkoff, D; Zhang, J; Klei, HE; Kish, K; Liu, EC; Hartl, KS; Seiler, SM; Chang, M; Huang, C; Youssef, S; Steinbacher, TE; Schumacher, WA; Grazier, N; Pudzianowski, A; Apedo, A; Discenza, L; Yanchunas, J; Stein, PD; Atwal, KS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26360&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91896049 56464797 51689 ZINC42876011 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 48050 CN(C)C(=O)C(C#N)C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1cccc2c(c[nH]c12)C#N InChI=1S/C27H32N8O3/c1-33(2)26(37)20(15-29)25(31-21-10-7-8-19-18(14-28)16-30-24(19)21)32-22-9-3-4-13-35(27(22)38)17-23(36)34-11-5-6-12-34/h7-8,10,16,20,22,30H,3-6,9,11-13,17H2,1-2H3,(H,31,32)/t20?,22-/m0/s1 NDKBELNDNOXNOM-IAXKEJLGSA-N 26361 (2Z)-2-cyano-3-[(3-cyano-1H-indol-7-yl)amino]-N,N-dimethyl-3-{[(3S)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepan-3-yl]amino}prop-2-enamide::3-cyanoindole compound, 22 Coagulation factor X Homo sapiens 290 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm800855x 10.7270/Q2V12332 18998662 aid1798672 Shi, Y; Sitkoff, D; Zhang, J; Klei, HE; Kish, K; Liu, EC; Hartl, KS; Seiler, SM; Chang, M; Huang, C; Youssef, S; Steinbacher, TE; Schumacher, WA; Grazier, N; Pudzianowski, A; Apedo, A; Discenza, L; Yanchunas, J; Stein, PD; Atwal, KS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26361&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 90835519 56464798 51689 ZINC40863652 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 48051 CN(C)C(=O)C(C#N)C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1cccc2c(c[nH]c12)C(N)=O InChI=1S/C27H34N8O4/c1-33(2)26(38)18(14-28)25(31-20-10-7-8-17-19(24(29)37)15-30-23(17)20)32-21-9-3-4-13-35(27(21)39)16-22(36)34-11-5-6-12-34/h7-8,10,15,18,21,30H,3-6,9,11-13,16H2,1-2H3,(H2,29,37)(H,31,32)/t18?,21-/m0/s1 JIBXDTGKPQECST-ZYZRXSCRSA-N 26362 3-carboxamide indole compound, 23::7-{[(1Z)-2-cyano-2-(dimethylcarbamoyl)-1-{[(3S)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepan-3-yl]amino}eth-1-en-1-yl]amino}-1H-indole-3-carboxamide Coagulation factor X Homo sapiens 17000 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm800855x 10.7270/Q2V12332 18998662 aid1798672 Shi, Y; Sitkoff, D; Zhang, J; Klei, HE; Kish, K; Liu, EC; Hartl, KS; Seiler, SM; Chang, M; Huang, C; Youssef, S; Steinbacher, TE; Schumacher, WA; Grazier, N; Pudzianowski, A; Apedo, A; Discenza, L; Yanchunas, J; Stein, PD; Atwal, KS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26362&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91158867 56464799 51689 ZINC44386421 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 48052 Cc1c[nH]c2c(cccc12)N=C(NC#N)N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O InChI=1S/C23H29N7O2/c1-16-13-25-21-17(16)7-6-9-18(21)27-23(26-15-24)28-19-8-2-3-12-30(22(19)32)14-20(31)29-10-4-5-11-29/h6-7,9,13,19,25H,2-5,8,10-12,14H2,1H3,(H2,26,27,28)/t19-/m0/s1 LZFHYIGXOYFDCJ-IBGZPJMESA-N 26363 (3S)-2-cyano-1-(3-methyl-1H-indol-7-yl)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepane-3-guanidine::3-methylindole compound, 25 Coagulation factor X Homo sapiens 336 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm800855x 10.7270/Q2V12332 18998662 aid1798672 Shi, Y; Sitkoff, D; Zhang, J; Klei, HE; Kish, K; Liu, EC; Hartl, KS; Seiler, SM; Chang, M; Huang, C; Youssef, S; Steinbacher, TE; Schumacher, WA; Grazier, N; Pudzianowski, A; Apedo, A; Discenza, L; Yanchunas, J; Stein, PD; Atwal, KS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26363&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 25138146 56464800 ZINC62233001 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 48053 Clc1c[nH]c2c(cccc12)N=C(NC#N)N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O InChI=1S/C22H26ClN7O2/c23-16-12-25-20-15(16)6-5-8-17(20)27-22(26-14-24)28-18-7-1-2-11-30(21(18)32)13-19(31)29-9-3-4-10-29/h5-6,8,12,18,25H,1-4,7,9-11,13H2,(H2,26,27,28)/t18-/m0/s1 GMKVIXQDIDTCNX-SFHVURJKSA-N 26364 (3S)-1-(3-chloro-1H-indol-7-yl)-2-cyano-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepane-3-guanidine::3-chloroindole compound, 26 Coagulation factor X Homo sapiens 46 7.4 22.00 C Curated from the literature by BindingDB 10.1021/jm800855x 10.7270/Q2V12332 18998662 aid1798672 Shi, Y; Sitkoff, D; Zhang, J; Klei, HE; Kish, K; Liu, EC; Hartl, KS; Seiler, SM; Chang, M; Huang, C; Youssef, S; Steinbacher, TE; Schumacher, WA; Grazier, N; Pudzianowski, A; Apedo, A; Discenza, L; Yanchunas, J; Stein, PD; Atwal, KS Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26364&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 25138147 56464801 ZINC62233008 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56676 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccccc1C(=O)Nc1ccc(cc1)C(N)=N InChI=1S/C26H26N4O4/c1-15(2)14-29-24(31)17-9-12-20(22(13-17)26(33)34)19-5-3-4-6-21(19)25(32)30-18-10-7-16(8-11-18)23(27)28/h3-13,15H,14H2,1-2H3,(H3,27,28)(H,29,31)(H,30,32)(H,33,34) OPEFANHGJWQXDF-UHFFFAOYSA-N 31459 CHEMBL224485::substituted biphenyl derivative, 21 Coagulation factor X Homo sapiens 103000 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31459&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 17809181 252615382 CHEMBL224485 ZINC28639762 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56677 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(O)cc1C(=O)Nc1ccc(cc1)C(N)=N InChI=1S/C26H26N4O5/c1-14(2)13-29-24(32)16-5-9-20(22(11-16)26(34)35)19-10-8-18(31)12-21(19)25(33)30-17-6-3-15(4-7-17)23(27)28/h3-12,14,31H,13H2,1-2H3,(H3,27,28)(H,29,32)(H,30,33)(H,34,35) JGVKSXDKYFNHKI-UHFFFAOYSA-N 31460 substituted biphenyl derivative, 36a Coagulation factor X Homo sapiens 50000 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31460&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592955 172097363 ZINC40423936 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56678 COc1ccc(c(c1)C(=O)Nc1ccc(cc1)C(N)=N)-c1ccc(cc1C(O)=O)C(=O)NCC(C)C InChI=1S/C27H28N4O5/c1-15(2)14-30-25(32)17-6-10-21(23(12-17)27(34)35)20-11-9-19(36-3)13-22(20)26(33)31-18-7-4-16(5-8-18)24(28)29/h4-13,15H,14H2,1-3H3,(H3,28,29)(H,30,32)(H,31,33)(H,34,35) JVXBUVJQTIKERQ-UHFFFAOYSA-N 31461 substituted biphenyl derivative, 24 Coagulation factor X Homo sapiens 6630 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31461&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 17809213 172097364 ZINC45496335 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56679 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(C=C)cc1C(=O)Nc1ccc(cc1)C(N)=N InChI=1S/C28H28N4O4/c1-4-17-5-11-21(23(13-17)27(34)32-20-9-6-18(7-10-20)25(29)30)22-12-8-19(14-24(22)28(35)36)26(33)31-15-16(2)3/h4-14,16H,1,15H2,2-3H3,(H3,29,30)(H,31,33)(H,32,34)(H,35,36) FCTCJAGJUHHZDO-UHFFFAOYSA-N 31462 substituted biphenyl derivative, 36b Coagulation factor X Homo sapiens 1650 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31462&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22336163 172097365 ZINC03971974 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56680 CCc1ccc(c(c1)C(=O)Nc1ccc(cc1)C(N)=N)-c1ccc(cc1C(O)=O)C(=O)NCC(C)C InChI=1S/C28H30N4O4/c1-4-17-5-11-21(23(13-17)27(34)32-20-9-6-18(7-10-20)25(29)30)22-12-8-19(14-24(22)28(35)36)26(33)31-15-16(2)3/h5-14,16H,4,15H2,1-3H3,(H3,29,30)(H,31,33)(H,32,34)(H,35,36) OLFYUUPVCGARIA-UHFFFAOYSA-N 31463 substituted biphenyl derivative, 36c Coagulation factor X Homo sapiens 50000 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31463&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592978 172097366 ZINC40411542 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56681 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(CC=C)cc1C(=O)Nc1ccc(cc1)C(N)=N InChI=1S/C29H30N4O4/c1-4-5-18-6-12-22(24(14-18)28(35)33-21-10-7-19(8-11-21)26(30)31)23-13-9-20(15-25(23)29(36)37)27(34)32-16-17(2)3/h4,6-15,17H,1,5,16H2,2-3H3,(H3,30,31)(H,32,34)(H,33,35)(H,36,37) PREVZZBJVCTDTQ-UHFFFAOYSA-N 31464 substituted biphenyl derivative, 36d Coagulation factor X Homo sapiens 1900 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31464&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22336180 172097367 ZINC45496107 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56682 CCCc1ccc(c(c1)C(=O)Nc1ccc(cc1)C(N)=N)-c1ccc(cc1C(O)=O)C(=O)NCC(C)C InChI=1S/C29H32N4O4/c1-4-5-18-6-12-22(24(14-18)28(35)33-21-10-7-19(8-11-21)26(30)31)23-13-9-20(15-25(23)29(36)37)27(34)32-16-17(2)3/h6-15,17H,4-5,16H2,1-3H3,(H3,30,31)(H,32,34)(H,33,35)(H,36,37) NDXKHAPOIIBQOC-UHFFFAOYSA-N 31465 substituted biphenyl derivative, 36e Coagulation factor X Homo sapiens 46050 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31465&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592617 172097368 ZINC40979588 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56683 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)C#C InChI=1S/C28H26N4O4/c1-4-17-5-11-21(23(13-17)27(34)32-20-9-6-18(7-10-20)25(29)30)22-12-8-19(14-24(22)28(35)36)26(33)31-15-16(2)3/h1,5-14,16H,15H2,2-3H3,(H3,29,30)(H,31,33)(H,32,34)(H,35,36) RXGWTRRHEHZYJO-UHFFFAOYSA-N 31466 substituted biphenyl derivative, 36f Coagulation factor X Homo sapiens 8140 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31466&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592979 172097369 ZINC45496301 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56684 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)C(C)=C InChI=1S/C29H30N4O4/c1-16(2)15-32-27(34)20-8-12-23(25(14-20)29(36)37)22-11-7-19(17(3)4)13-24(22)28(35)33-21-9-5-18(6-10-21)26(30)31/h5-14,16H,3,15H2,1-2,4H3,(H3,30,31)(H,32,34)(H,33,35)(H,36,37) DKFBIZDHPKUBIT-UHFFFAOYSA-N 31467 substituted biphenyl derivative, 36g Coagulation factor X Homo sapiens 1170 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31467&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44593006 172097370 ZINC40943114 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56685 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(C=C=C)cc1C(=O)Nc1ccc(cc1)C(N)=N InChI=1S/C29H28N4O4/c1-4-5-18-6-12-22(24(14-18)28(35)33-21-10-7-19(8-11-21)26(30)31)23-13-9-20(15-25(23)29(36)37)27(34)32-16-17(2)3/h5-15,17H,1,16H2,2-3H3,(H3,30,31)(H,32,34)(H,33,35)(H,36,37) MYYPVSMRQLUUCW-UHFFFAOYSA-N 31468 substituted biphenyl derivative, 36h Coagulation factor X Homo sapiens 1500 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31468&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44593007 172097371 ZINC40423500 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56686 CC#Cc1ccc(c(c1)C(=O)Nc1ccc(cc1)C(N)=N)-c1ccc(cc1C(O)=O)C(=O)NCC(C)C InChI=1S/C29H28N4O4/c1-4-5-18-6-12-22(24(14-18)28(35)33-21-10-7-19(8-11-21)26(30)31)23-13-9-20(15-25(23)29(36)37)27(34)32-16-17(2)3/h6-15,17H,16H2,1-3H3,(H3,30,31)(H,32,34)(H,33,35)(H,36,37) FNPAYHPYLXUHPD-UHFFFAOYSA-N 31469 substituted biphenyl derivative, 36i Coagulation factor X Homo sapiens 5220 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31469&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22336133 172097372 ZINC40939968 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56687 C\C=C/Cc1ccc(c(c1)C(=O)Nc1ccc(cc1)C(N)=N)-c1ccc(cc1C(O)=O)C(=O)NCC(C)C InChI=1S/C30H32N4O4/c1-4-5-6-19-7-13-23(25(15-19)29(36)34-22-11-8-20(9-12-22)27(31)32)24-14-10-21(16-26(24)30(37)38)28(35)33-17-18(2)3/h4-5,7-16,18H,6,17H2,1-3H3,(H3,31,32)(H,33,35)(H,34,36)(H,37,38)/b5-4- UHSOJTIMDDIBQO-PLNGDYQASA-N 31470 substituted biphenyl derivative, 36j Coagulation factor X Homo sapiens 7600 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31470&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44593008 172097373 ZINC40410415 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56688 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(CC=C(C)C)cc1C(=O)Nc1ccc(cc1)C(N)=N InChI=1S/C31H34N4O4/c1-18(2)5-6-20-7-13-24(26(15-20)30(37)35-23-11-8-21(9-12-23)28(32)33)25-14-10-22(16-27(25)31(38)39)29(36)34-17-19(3)4/h5,7-16,19H,6,17H2,1-4H3,(H3,32,33)(H,34,36)(H,35,37)(H,38,39) WBPLJGAAZCZXSP-UHFFFAOYSA-N 31471 substituted biphenyl derivative, 36k Coagulation factor X Homo sapiens 26960 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31471&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592560 172097374 ZINC40424612 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56689 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(\C=C/C(C)=C)cc1C(=O)Nc1ccc(cc1)C(N)=N InChI=1S/C31H32N4O4/c1-18(2)5-6-20-7-13-24(26(15-20)30(37)35-23-11-8-21(9-12-23)28(32)33)25-14-10-22(16-27(25)31(38)39)29(36)34-17-19(3)4/h5-16,19H,1,17H2,2-4H3,(H3,32,33)(H,34,36)(H,35,37)(H,38,39)/b6-5- JFLGQUGULDSYQV-WAYWQWQTSA-N 31472 substituted biphenyl derivative, 36l Coagulation factor X Homo sapiens 310 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31472&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592561 172097375 ZINC40980235 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56690 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(\C=C/CO)cc1C(=O)Nc1ccc(cc1)C(N)=N InChI=1S/C29H30N4O5/c1-17(2)16-32-27(35)20-8-12-23(25(15-20)29(37)38)22-11-5-18(4-3-13-34)14-24(22)28(36)33-21-9-6-19(7-10-21)26(30)31/h3-12,14-15,17,34H,13,16H2,1-2H3,(H3,30,31)(H,32,35)(H,33,36)(H,37,38)/b4-3- RMVFYPMRRGCHJM-ARJAWSKDSA-N 31473 substituted biphenyl derivative, 36m Coagulation factor X Homo sapiens 6620 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31473&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72699228 172097376 ZINC62241657 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56691 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)C(=C)CO InChI=1S/C29H30N4O5/c1-16(2)14-32-27(35)20-7-11-23(25(13-20)29(37)38)22-10-6-19(17(3)15-34)12-24(22)28(36)33-21-8-4-18(5-9-21)26(30)31/h4-13,16,34H,3,14-15H2,1-2H3,(H3,30,31)(H,32,35)(H,33,36)(H,37,38) KTKCXWRXASRRSD-UHFFFAOYSA-N 31474 substituted biphenyl derivative, 36n Coagulation factor X Homo sapiens 7100 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31474&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44188281 172097377 ZINC40429104 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56692 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)C(=C)CCO InChI=1S/C30H32N4O5/c1-17(2)16-33-28(36)21-7-11-24(26(15-21)30(38)39)23-10-6-20(18(3)12-13-35)14-25(23)29(37)34-22-8-4-19(5-9-22)27(31)32/h4-11,14-15,17,35H,3,12-13,16H2,1-2H3,(H3,31,32)(H,33,36)(H,34,37)(H,38,39) BUIUMQPEDCQMFD-UHFFFAOYSA-N 31475 substituted biphenyl derivative, 36o Coagulation factor X Homo sapiens 11270 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31475&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592593 172097378 ZINC40979630 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56693 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)C#CCCO InChI=1S/C30H30N4O5/c1-18(2)17-33-28(36)21-9-13-24(26(16-21)30(38)39)23-12-6-19(5-3-4-14-35)15-25(23)29(37)34-22-10-7-20(8-11-22)27(31)32/h6-13,15-16,18,35H,4,14,17H2,1-2H3,(H3,31,32)(H,33,36)(H,34,37)(H,38,39) RPWMNCDNXZFZIK-UHFFFAOYSA-N 31477 substituted biphenyl derivative, 36q Coagulation factor X Homo sapiens 59000 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31477&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22336148 172097380 ZINC40979711 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56694 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)C(O)CO InChI=1S/C28H30N4O6/c1-15(2)13-31-26(35)18-6-10-21(23(12-18)28(37)38)20-9-5-17(24(34)14-33)11-22(20)27(36)32-19-7-3-16(4-8-19)25(29)30/h3-12,15,24,33-34H,13-14H2,1-2H3,(H3,29,30)(H,31,35)(H,32,36)(H,37,38) PVBZWKGRSQGPPR-UHFFFAOYSA-N 31479 substituted biphenyl derivative, 36s Coagulation factor X Homo sapiens 50000 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31479&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592658 172097382 ZINC40424856 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56695 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1ccccc1 InChI=1S/C32H30N4O4/c1-19(2)18-35-30(37)23-11-15-26(28(17-23)32(39)40)25-14-10-22(20-6-4-3-5-7-20)16-27(25)31(38)36-24-12-8-21(9-13-24)29(33)34/h3-17,19H,18H2,1-2H3,(H3,33,34)(H,35,37)(H,36,38)(H,39,40) GVACGRWTTRFLEX-UHFFFAOYSA-N 31482 substituted biphenyl derivative, 36v Coagulation factor X Homo sapiens 350 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31482&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22336153 172097385 ZINC42920672 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56696 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(Cc2ccccc2)cc1C(=O)Nc1ccc(cc1)C(N)=N InChI=1S/C33H32N4O4/c1-20(2)19-36-31(38)24-11-15-27(29(18-24)33(40)41)26-14-8-22(16-21-6-4-3-5-7-21)17-28(26)32(39)37-25-12-9-23(10-13-25)30(34)35/h3-15,17-18,20H,16,19H2,1-2H3,(H3,34,35)(H,36,38)(H,37,39)(H,40,41) GEJPIBYDWDPPLK-UHFFFAOYSA-N 31483 substituted biphenyl derivative, 36w Coagulation factor X Homo sapiens 1750 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31483&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592888 172097386 ZINC42891964 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56697 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1ccncc1 InChI=1S/C31H29N5O4/c1-18(2)17-35-29(37)22-6-10-25(27(16-22)31(39)40)24-9-5-21(19-11-13-34-14-12-19)15-26(24)30(38)36-23-7-3-20(4-8-23)28(32)33/h3-16,18H,17H2,1-2H3,(H3,32,33)(H,35,37)(H,36,38)(H,39,40) YGUNDOMQXJSNFY-UHFFFAOYSA-N 31484 substituted biphenyl derivative, 36x Coagulation factor X Homo sapiens 19410 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31484&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22336121 172097387 ZINC01911193 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56698 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1cccnc1 InChI=1S/C31H29N5O4/c1-18(2)16-35-29(37)21-8-12-25(27(15-21)31(39)40)24-11-7-20(22-4-3-13-34-17-22)14-26(24)30(38)36-23-9-5-19(6-10-23)28(32)33/h3-15,17-18H,16H2,1-2H3,(H3,32,33)(H,35,37)(H,36,38)(H,39,40) QZHVHPIWETWGAQ-UHFFFAOYSA-N 31485 substituted biphenyl derivative, 36y Coagulation factor X Homo sapiens 36490 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31485&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592693 172097388 ZINC42835063 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56699 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1cccs1 InChI=1S/C30H28N4O4S/c1-17(2)16-33-28(35)20-8-12-23(25(15-20)30(37)38)22-11-7-19(26-4-3-13-39-26)14-24(22)29(36)34-21-9-5-18(6-10-21)27(31)32/h3-15,17H,16H2,1-2H3,(H3,31,32)(H,33,35)(H,34,36)(H,37,38) WZCKHEIOLVYNTQ-UHFFFAOYSA-N 31486 substituted biphenyl derivative, 36z Coagulation factor X Homo sapiens 150 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31486&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22336150 172097389 ZINC42835079 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56700 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1ccsc1 InChI=1S/C30H28N4O4S/c1-17(2)15-33-28(35)20-6-10-24(26(14-20)30(37)38)23-9-5-19(21-11-12-39-16-21)13-25(23)29(36)34-22-7-3-18(4-8-22)27(31)32/h3-14,16-17H,15H2,1-2H3,(H3,31,32)(H,33,35)(H,34,36)(H,37,38) OCNKSJHQWUSIRB-UHFFFAOYSA-N 31487 substituted biphenyl derivative, 36aa Coagulation factor X Homo sapiens 40 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31487&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22336151 172097390 ZINC42835081 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56737 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1ccoc1 InChI=1S/C30H28N4O5/c1-17(2)15-33-28(35)20-6-10-24(26(14-20)30(37)38)23-9-5-19(21-11-12-39-16-21)13-25(23)29(36)34-22-7-3-18(4-8-22)27(31)32/h3-14,16-17H,15H2,1-2H3,(H3,31,32)(H,33,35)(H,34,36)(H,37,38) QAIZMIBCSNGQKN-UHFFFAOYSA-N 31489 substituted biphenyl derivative, 36ac Coagulation factor X Homo sapiens 120 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31489&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22336143 172097392 ZINC40979195 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56738 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1ccc[nH]1 InChI=1S/C30H29N5O4/c1-17(2)16-34-28(36)20-8-12-23(25(15-20)30(38)39)22-11-7-19(26-4-3-13-33-26)14-24(22)29(37)35-21-9-5-18(6-10-21)27(31)32/h3-15,17,33H,16H2,1-2H3,(H3,31,32)(H,34,36)(H,35,37)(H,38,39) XTUJNPODMRCIHC-UHFFFAOYSA-N 31490 substituted biphenyl derivative, 36ad Coagulation factor X Homo sapiens 50 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31490&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22336181 172097393 ZINC40428757 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56739 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1cccn1C InChI=1S/C31H31N5O4/c1-18(2)17-34-29(37)21-9-13-24(26(16-21)31(39)40)23-12-8-20(27-5-4-14-36(27)3)15-25(23)30(38)35-22-10-6-19(7-11-22)28(32)33/h4-16,18H,17H2,1-3H3,(H3,32,33)(H,34,37)(H,35,38)(H,39,40) SYSCAMXJUQSOPK-UHFFFAOYSA-N 31491 substituted biphenyl derivative, 36ae Coagulation factor X Homo sapiens 50 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31491&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592765 172097394 ZINC42921367 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56740 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1nccs1 InChI=1S/C29H27N5O4S/c1-16(2)15-33-26(35)18-5-9-22(24(13-18)29(37)38)21-10-6-19(28-32-11-12-39-28)14-23(21)27(36)34-20-7-3-17(4-8-20)25(30)31/h3-14,16H,15H2,1-2H3,(H3,30,31)(H,33,35)(H,34,36)(H,37,38) JHMLZMRJAKCEAM-UHFFFAOYSA-N 31492 substituted biphenyl derivative, 36af Coagulation factor X Homo sapiens 230 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31492&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22336174 172097395 ZINC01911200 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56741 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(Cc2cccs2)cc1C(=O)Nc1ccc(cc1)C(N)=N InChI=1S/C31H30N4O4S/c1-18(2)17-34-29(36)21-8-12-25(27(16-21)31(38)39)24-11-5-19(14-23-4-3-13-40-23)15-26(24)30(37)35-22-9-6-20(7-10-22)28(32)33/h3-13,15-16,18H,14,17H2,1-2H3,(H3,32,33)(H,34,36)(H,35,37)(H,38,39) ZTMVWIJIHZGCIY-UHFFFAOYSA-N 31493 substituted biphenyl derivative, 36ag Coagulation factor X Homo sapiens 8150 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31493&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22336142 172097396 ZINC42920918 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56742 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1ccsc1CO InChI=1S/C31H30N4O5S/c1-17(2)15-34-29(37)20-6-10-24(26(14-20)31(39)40)23-9-5-19(22-11-12-41-27(22)16-36)13-25(23)30(38)35-21-7-3-18(4-8-21)28(32)33/h3-14,17,36H,15-16H2,1-2H3,(H3,32,33)(H,34,37)(H,35,38)(H,39,40) REKBLSLNDZXMEV-UHFFFAOYSA-N 31495 substituted biphenyl derivative, 36ai Coagulation factor X Homo sapiens 450 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31495&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22336172 172097398 ZINC49888959 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56743 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1sccc1CO InChI=1S/C31H30N4O5S/c1-17(2)15-34-29(37)20-6-10-24(26(14-20)31(39)40)23-9-5-19(27-21(16-36)11-12-41-27)13-25(23)30(38)35-22-7-3-18(4-8-22)28(32)33/h3-14,17,36H,15-16H2,1-2H3,(H3,32,33)(H,34,37)(H,35,38)(H,39,40) JMBFMRIGGCGNMP-UHFFFAOYSA-N 31496 substituted biphenyl derivative, 36aj Coagulation factor X Homo sapiens 640 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31496&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22336127 172097399 ZINC42805998 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56744 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1cscc1CO InChI=1S/C31H30N4O5S/c1-17(2)13-34-29(37)20-6-10-24(26(12-20)31(39)40)23-9-5-19(27-16-41-15-21(27)14-36)11-25(23)30(38)35-22-7-3-18(4-8-22)28(32)33/h3-12,15-17,36H,13-14H2,1-2H3,(H3,32,33)(H,34,37)(H,35,38)(H,39,40) RSIRPNPAPRYLFZ-UHFFFAOYSA-N 31497 substituted biphenyl derivative, 36ak Coagulation factor X Homo sapiens 130 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31497&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592831 172097400 ZINC42806003 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56745 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1cscc1CN=[N+]=[N-] InChI=1S/C31H29N7O4S/c1-17(2)13-35-29(39)20-6-10-24(26(12-20)31(41)42)23-9-5-19(27-16-43-15-21(27)14-36-38-34)11-25(23)30(40)37-22-7-3-18(4-8-22)28(32)33/h3-12,15-17H,13-14H2,1-2H3,(H3,32,33)(H,35,39)(H,37,40)(H,41,42) JSMHBBVRPWBLOR-UHFFFAOYSA-N 31499 substituted biphenyl derivative, 36am Coagulation factor X Homo sapiens 50 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31499&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592833 172097402 ZINC44350849 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56746 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1cscc1CN InChI=1S/C31H31N5O4S/c1-17(2)14-35-29(37)20-6-10-24(26(12-20)31(39)40)23-9-5-19(27-16-41-15-21(27)13-32)11-25(23)30(38)36-22-7-3-18(4-8-22)28(33)34/h3-12,15-17H,13-14,32H2,1-2H3,(H3,33,34)(H,35,37)(H,36,38)(H,39,40) NRTPJMXYAMIJHJ-UHFFFAOYSA-N 31500 substituted biphenyl derivative, 36an Coagulation factor X Homo sapiens 10 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31500&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20631502 172097403 ZINC42833767 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56747 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1ccoc1CO InChI=1S/C31H30N4O6/c1-17(2)15-34-29(37)20-6-10-24(26(14-20)31(39)40)23-9-5-19(22-11-12-41-27(22)16-36)13-25(23)30(38)35-21-7-3-18(4-8-21)28(32)33/h3-14,17,36H,15-16H2,1-2H3,(H3,32,33)(H,34,37)(H,35,38)(H,39,40) WLBRATSWGHWZND-UHFFFAOYSA-N 31501 substituted biphenyl derivative, 36ao Coagulation factor X Homo sapiens 20 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31501&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592864 172097404 ZINC42834749 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56748 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1cocc1CO InChI=1S/C31H30N4O6/c1-17(2)13-34-29(37)20-6-10-24(26(12-20)31(39)40)23-9-5-19(27-16-41-15-21(27)14-36)11-25(23)30(38)35-22-7-3-18(4-8-22)28(32)33/h3-12,15-17,36H,13-14H2,1-2H3,(H3,32,33)(H,34,37)(H,35,38)(H,39,40) MISOKRMZLXAKLN-UHFFFAOYSA-N 31502 substituted biphenyl derivative, 36ap Coagulation factor X Homo sapiens 230 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31502&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592865 172097405 ZINC42890160 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56749 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1occc1CO InChI=1S/C31H30N4O6/c1-17(2)15-34-29(37)20-6-10-24(26(14-20)31(39)40)23-9-5-19(27-21(16-36)11-12-41-27)13-25(23)30(38)35-22-7-3-18(4-8-22)28(32)33/h3-14,17,36H,15-16H2,1-2H3,(H3,32,33)(H,34,37)(H,35,38)(H,39,40) GFQUGBZAHVGALJ-UHFFFAOYSA-N 31503 substituted biphenyl derivative, 36aq Coagulation factor X Homo sapiens 150 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31503&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22336146 172097406 ZINC42803331 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 56750 CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(cc1C(=O)Nc1ccc(cc1)C(N)=N)-c1ccco1 InChI=1S/C30H28N4O5/c1-17(2)16-33-28(35)20-8-12-23(25(15-20)30(37)38)22-11-7-19(26-4-3-13-39-26)14-24(22)29(36)34-21-9-5-18(6-10-21)27(31)32/h3-15,17H,16H2,1-2H3,(H3,31,32)(H,33,35)(H,34,36)(H,37,38) BQDYQUZLQVWWMF-UHFFFAOYSA-N 31488 substituted biphenyl derivative, 36ab Coagulation factor X Homo sapiens 1300 25.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.04.013 10.7270/Q2SX6BJN 19409795 aid1799135 Kotian, PL; Krishnan, R; Rowland, S; El-Kattan, Y; Saini, SK; Upshaw, R; Bantia, S; Arnold, S; Babu, YS; Chand, P BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31488&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44592729 172097391 ZINC40980000 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63401 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C26H31ClN6O3S/c1-32(2)26(36)14-4-6-18(29-23(34)21-12-15-10-16(27)5-7-17(15)28-21)20(11-14)30-24(35)25-31-19-8-9-33(3)13-22(19)37-25/h5,7,10,12,14,18,20,28H,4,6,8-9,11,13H2,1-3H3,(H,29,34)(H,30,35)/t14-,18-,20+/m0/s1 SZBHQQIIGORYND-ADLFWFRXSA-N 35743 CHEMBL479863::cis-1,2-diaminocyclohexane derivative, A Coagulation factor X Homo sapiens 2.3 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35743&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search DT8 2EI8 9808346 85856536 CHEMBL479863 ZINC24745003 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63402 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cn3ccc(Cl)cc3n2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C25H30ClN7O3S/c1-31(2)25(36)14-4-5-16(28-22(34)19-12-33-9-6-15(26)11-21(33)27-19)18(10-14)29-23(35)24-30-17-7-8-32(3)13-20(17)37-24/h6,9,11-12,14,16,18H,4-5,7-8,10,13H2,1-3H3,(H,28,34)(H,29,35)/t14-,16-,18+/m0/s1 BMQNRNJEGSOAQO-QILLFSRXSA-N 35744 cis-1,2-diaminocyclohexane derivative, 8a Coagulation factor X Homo sapiens 120 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35744&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520907 85856537 ZINC49771277 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63403 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3cc(Cl)ccc3o2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C26H30ClN5O4S/c1-31(2)26(35)14-4-6-17(28-23(33)21-12-15-10-16(27)5-7-20(15)36-21)19(11-14)29-24(34)25-30-18-8-9-32(3)13-22(18)37-25/h5,7,10,12,14,17,19H,4,6,8-9,11,13H2,1-3H3,(H,28,33)(H,29,34)/t14-,17-,19+/m0/s1 OXDWZBAYLRPOQJ-UCLAIMLFSA-N 35745 cis-1,2-diaminocyclohexane derivative, 8b Coagulation factor X Homo sapiens 1100 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35745&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520908 85856538 ZINC49756427 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63404 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3ccc(Cl)cc3o2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C26H30ClN5O4S/c1-31(2)26(35)15-5-7-17(28-23(33)21-11-14-4-6-16(27)12-20(14)36-21)19(10-15)29-24(34)25-30-18-8-9-32(3)13-22(18)37-25/h4,6,11-12,15,17,19H,5,7-10,13H2,1-3H3,(H,28,33)(H,29,34)/t15-,17-,19+/m0/s1 PGHUVZYEMDTBOA-VDZJLULYSA-N 35746 cis-1,2-diaminocyclohexane derivative, 8c Coagulation factor X Homo sapiens 1900 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35746&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520909 85856539 ZINC49767136 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63405 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2nc3cc(Cl)ccc3s2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C25H29ClN6O3S2/c1-31(2)25(35)13-4-6-15(27-21(33)24-30-18-11-14(26)5-7-19(18)36-24)17(10-13)28-22(34)23-29-16-8-9-32(3)12-20(16)37-23/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,34)/t13-,15-,17+/m0/s1 ZTOIPRGDUQHISA-JLJPHGGASA-N 35747 cis-1,2-diaminocyclohexane derivative, 8d Coagulation factor X Homo sapiens 2300 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35747&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520910 85856540 ZINC49757228 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63406 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2nc3ccc(Cl)cc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C25H30ClN7O3S/c1-32(2)25(36)13-4-6-16(29-22(34)21-27-15-7-5-14(26)11-19(15)28-21)18(10-13)30-23(35)24-31-17-8-9-33(3)12-20(17)37-24/h5,7,11,13,16,18H,4,6,8-10,12H2,1-3H3,(H,27,28)(H,29,34)(H,30,35)/t13-,16-,18+/m0/s1 ULJORWGWMSQAAC-QANKJYHBSA-N 35748 cis-1,2-diaminocyclohexane derivative, 8e Coagulation factor X Homo sapiens 6.5 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35748&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16660968 85856541 ZINC49757276 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63407 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3cc(Cl)ncc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C25H30ClN7O3S/c1-32(2)25(36)13-4-5-15(29-22(34)18-9-14-10-21(26)27-11-19(14)28-18)17(8-13)30-23(35)24-31-16-6-7-33(3)12-20(16)37-24/h9-11,13,15,17,28H,4-8,12H2,1-3H3,(H,29,34)(H,30,35)/t13-,15-,17+/m0/s1 MZKORJAMCPLKHK-JLJPHGGASA-N 35749 cis-1,2-diaminocyclohexane derivative, 8f Coagulation factor X Homo sapiens 69 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35749&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520911 85856542 ZINC49762337 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63408 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3nc(Cl)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C25H30ClN7O3S/c1-32(2)25(36)13-4-5-15(29-22(34)19-11-18-14(27-19)6-7-21(26)28-18)17(10-13)30-23(35)24-31-16-8-9-33(3)12-20(16)37-24/h6-7,11,13,15,17,27H,4-5,8-10,12H2,1-3H3,(H,29,34)(H,30,35)/t13-,15-,17+/m0/s1 PXTUJKPBKRSACG-JLJPHGGASA-N 35750 cis-1,2-diaminocyclohexane derivative, 8g Coagulation factor X Homo sapiens 55 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35750&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520912 85856543 ZINC49756414 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63409 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3c(F)c(Cl)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C26H30ClFN6O3S/c1-33(2)26(37)13-4-6-17(30-23(35)20-11-14-16(29-20)7-5-15(27)22(14)28)19(10-13)31-24(36)25-32-18-8-9-34(3)12-21(18)38-25/h5,7,11,13,17,19,29H,4,6,8-10,12H2,1-3H3,(H,30,35)(H,31,36)/t13-,17-,19+/m0/s1 VEJHUCHPLUJJEC-SOVGHPHASA-N 35751 cis-1,2-diaminocyclohexane derivative, 8h Coagulation factor X Homo sapiens 1.4 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35751&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520913 85856544 ZINC49767054 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63410 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3cc(Cl)cc(F)c3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C26H30ClFN6O3S/c1-33(2)26(37)13-4-5-17(30-23(35)20-10-14-8-15(27)11-16(28)22(14)29-20)19(9-13)31-24(36)25-32-18-6-7-34(3)12-21(18)38-25/h8,10-11,13,17,19,29H,4-7,9,12H2,1-3H3,(H,30,35)(H,31,36)/t13-,17-,19+/m0/s1 JEZONOMJOXBMHF-SOVGHPHASA-N 35752 cis-1,2-diaminocyclohexane derivative, 8i Coagulation factor X Homo sapiens 49 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35752&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520914 85856545 ZINC49766888 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63411 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2[nH]c3ccc(Cl)cc3c2F)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C26H30ClFN6O3S/c1-33(2)26(37)13-4-6-17(30-23(35)22-21(28)15-11-14(27)5-7-16(15)29-22)19(10-13)31-24(36)25-32-18-8-9-34(3)12-20(18)38-25/h5,7,11,13,17,19,29H,4,6,8-10,12H2,1-3H3,(H,30,35)(H,31,36)/t13-,17-,19+/m0/s1 MVAVQDNPGSCRCB-SOVGHPHASA-N 35753 cis-1,2-diaminocyclohexane derivative, 8j Coagulation factor X Homo sapiens 3.5 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35753&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520915 85856546 ZINC49757477 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63412 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2[nH]c3ccc(Cl)cc3c2Br)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C26H30BrClN6O3S/c1-33(2)26(37)13-4-6-17(30-23(35)22-21(27)15-11-14(28)5-7-16(15)29-22)19(10-13)31-24(36)25-32-18-8-9-34(3)12-20(18)38-25/h5,7,11,13,17,19,29H,4,6,8-10,12H2,1-3H3,(H,30,35)(H,31,36)/t13-,17-,19+/m0/s1 DCEKHWXALSASNF-SOVGHPHASA-N 35754 cis-1,2-diaminocyclohexane derivative, 8k Coagulation factor X Homo sapiens 4.8 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35754&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520916 85856547 ZINC49756987 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63413 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2[nH]c3ccc(F)cc3c2Cl)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C26H30ClFN6O3S/c1-33(2)26(37)13-4-6-17(30-23(35)22-21(27)15-11-14(28)5-7-16(15)29-22)19(10-13)31-24(36)25-32-18-8-9-34(3)12-20(18)38-25/h5,7,11,13,17,19,29H,4,6,8-10,12H2,1-3H3,(H,30,35)(H,31,36)/t13-,17-,19+/m0/s1 PRNHFCBYKORVPK-SOVGHPHASA-N 35755 cis-1,2-diaminocyclohexane derivative, 8l Coagulation factor X Homo sapiens 5.7 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35755&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520917 85856548 ZINC49771256 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63414 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2[nH]c3ccc(Cl)cc3c2C=O)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C27H31ClN6O4S/c1-33(2)27(38)14-4-6-19(30-24(36)23-17(13-35)16-11-15(28)5-7-18(16)29-23)21(10-14)31-25(37)26-32-20-8-9-34(3)12-22(20)39-26/h5,7,11,13-14,19,21,29H,4,6,8-10,12H2,1-3H3,(H,30,36)(H,31,37)/t14-,19-,21+/m0/s1 CFKFDPIYKGDUPV-ONTRVFCTSA-N 35756 cis-1,2-diaminocyclohexane derivative, 8m Coagulation factor X Homo sapiens 2.1 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35756&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16660960 85856549 ZINC49762212 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63415 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2[nH]c3ccc(Cl)cc3c2C(=O)N(C)C)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C29H36ClN7O4S/c1-35(2)28(40)15-6-8-19(21(12-15)33-26(39)27-34-20-10-11-37(5)14-22(20)42-27)32-25(38)24-23(29(41)36(3)4)17-13-16(30)7-9-18(17)31-24/h7,9,13,15,19,21,31H,6,8,10-12,14H2,1-5H3,(H,32,38)(H,33,39)/t15-,19-,21+/m0/s1 WCOFJANBYJEZLV-PAXLWEDBSA-N 35757 cis-1,2-diaminocyclohexane derivative, 8n Coagulation factor X Homo sapiens 37 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35757&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16660962 85856550 ZINC49756202 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63416 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3cc(F)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C26H31FN6O3S/c1-32(2)26(36)14-4-6-18(29-23(34)21-12-15-10-16(27)5-7-17(15)28-21)20(11-14)30-24(35)25-31-19-8-9-33(3)13-22(19)37-25/h5,7,10,12,14,18,20,28H,4,6,8-9,11,13H2,1-3H3,(H,29,34)(H,30,35)/t14-,18-,20+/m0/s1 MFXVEJMJXBUBJG-ADLFWFRXSA-N 35758 cis-1,2-diaminocyclohexane derivative, 8o Coagulation factor X Homo sapiens 15 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35758&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520918 85856551 ZINC45350477 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63417 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3cc(Br)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C26H31BrN6O3S/c1-32(2)26(36)14-4-6-18(29-23(34)21-12-15-10-16(27)5-7-17(15)28-21)20(11-14)30-24(35)25-31-19-8-9-33(3)13-22(19)37-25/h5,7,10,12,14,18,20,28H,4,6,8-9,11,13H2,1-3H3,(H,29,34)(H,30,35)/t14-,18-,20+/m0/s1 XWNNEAYWKBHARN-ADLFWFRXSA-N 35759 cis-1,2-diaminocyclohexane derivative, 8p Coagulation factor X Homo sapiens 3.2 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.023 10.7270/Q2H130CP 19884015 aid1799341 Yoshikawa, K; Yokomizo, A; Naito, H; Haginoya, N; Kobayashi, S; Yoshino, T; Nagata, T; Mochizuki, A; Osanai, K; Watanabe, K; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35759&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520919 85856552 ZINC49757446 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63418 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C26H31ClN6O3S/c1-32(2)26(36)14-4-6-18(29-23(34)21-12-15-10-16(27)5-7-17(15)28-21)20(11-14)30-24(35)25-31-19-8-9-33(3)13-22(19)37-25/h5,7,10,12,14,18,20,28H,4,6,8-9,11,13H2,1-3H3,(H,29,34)(H,30,35)/t14-,18-,20+/m0/s1 SZBHQQIIGORYND-ADLFWFRXSA-N 35743 CHEMBL479863::cis-1,2-diaminocyclohexane derivative, A Coagulation factor X Homo sapiens 2.3 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.024 10.7270/Q2CC0Z1V 19900814 aid1799342 Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35743&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search DT8 2EI8 9808346 85856536 CHEMBL479863 ZINC24745003 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63419 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2ccc3cc(Cl)ccc3c2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C28H32ClN5O3S/c1-33(2)28(37)19-7-9-21(30-25(35)18-5-4-17-13-20(29)8-6-16(17)12-18)23(14-19)31-26(36)27-32-22-10-11-34(3)15-24(22)38-27/h4-6,8,12-13,19,21,23H,7,9-11,14-15H2,1-3H3,(H,30,35)(H,31,36)/t19-,21-,23+/m0/s1 BLIHXFNPRDSWKB-IEIRFRATSA-N 35760 cis-1,2-diaminocyclohexane derivative, 5a Coagulation factor X Homo sapiens 5.7 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.024 10.7270/Q2CC0Z1V 19900814 aid1799342 Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35760&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16660964 85856553 ZINC49756802 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63420 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2ccc3cc(Cl)ccc3n2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C27H31ClN6O3S/c1-33(2)27(37)16-5-7-19(30-24(35)21-8-4-15-12-17(28)6-9-18(15)29-21)22(13-16)31-25(36)26-32-20-10-11-34(3)14-23(20)38-26/h4,6,8-9,12,16,19,22H,5,7,10-11,13-14H2,1-3H3,(H,30,35)(H,31,36)/t16-,19-,22+/m0/s1 NBYHGOPTYAMMNR-XWFZLUIHSA-N 35761 cis-1,2-diaminocyclohexane derivative, 5b Coagulation factor X Homo sapiens 4000 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.024 10.7270/Q2CC0Z1V 19900814 aid1799342 Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35761&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520920 85856554 ZINC49767323 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63421 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3ccc(Cl)cc3cn2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C27H31ClN6O3S/c1-33(2)27(37)16-5-7-19(30-24(35)22-11-15-4-6-18(28)10-17(15)13-29-22)21(12-16)31-25(36)26-32-20-8-9-34(3)14-23(20)38-26/h4,6,10-11,13,16,19,21H,5,7-9,12,14H2,1-3H3,(H,30,35)(H,31,36)/t16-,19-,21+/m0/s1 XSJTYAFJNMRVBR-NBHGPNQESA-N 35762 cis-1,2-diaminocyclohexane derivative, 5c Coagulation factor X Homo sapiens 3 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.024 10.7270/Q2CC0Z1V 19900814 aid1799342 Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35762&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520921 85856555 ZINC49767610 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63422 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cnc3cc(Cl)ccc3c2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C27H31ClN6O3S/c1-33(2)27(37)16-5-7-19(30-24(35)17-10-15-4-6-18(28)12-21(15)29-13-17)22(11-16)31-25(36)26-32-20-8-9-34(3)14-23(20)38-26/h4,6,10,12-13,16,19,22H,5,7-9,11,14H2,1-3H3,(H,30,35)(H,31,36)/t16-,19-,22+/m0/s1 NKXJYUGBJUKWKU-XWFZLUIHSA-N 35763 cis-1,2-diaminocyclohexane derivative, 5d Coagulation factor X Homo sapiens 4.1 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.024 10.7270/Q2CC0Z1V 19900814 aid1799342 Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35763&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520922 85856556 ZINC49768004 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63423 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2ncc3cc(Cl)ccc3n2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C26H30ClN7O3S/c1-33(2)26(37)14-4-6-18(30-23(35)22-28-12-15-10-16(27)5-7-17(15)29-22)20(11-14)31-24(36)25-32-19-8-9-34(3)13-21(19)38-25/h5,7,10,12,14,18,20H,4,6,8-9,11,13H2,1-3H3,(H,30,35)(H,31,36)/t14-,18-,20+/m0/s1 CYEYXDKPFTXXAG-ADLFWFRXSA-N 35764 cis-1,2-diaminocyclohexane derivative, 5e Coagulation factor X Homo sapiens 870 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.024 10.7270/Q2CC0Z1V 19900814 aid1799342 Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35764&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520923 85856557 ZINC49757364 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63424 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3ccc(Cl)cc3nn2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C26H30ClN7O3S/c1-33(2)26(37)15-5-7-17(28-23(35)21-10-14-4-6-16(27)12-19(14)31-32-21)20(11-15)29-24(36)25-30-18-8-9-34(3)13-22(18)38-25/h4,6,10,12,15,17,20H,5,7-9,11,13H2,1-3H3,(H,28,35)(H,29,36)/t15-,17-,20+/m0/s1 PNQXOEXOFLZKCD-RIFZZMRRSA-N 35765 cis-1,2-diaminocyclohexane derivative, 5f Coagulation factor X Homo sapiens 3.3 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.024 10.7270/Q2CC0Z1V 19900814 aid1799342 Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35765&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16660966 85856558 ZINC49762136 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63425 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)C2=Cc3ccc(Cl)cc3OC2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C27H32ClN5O4S/c1-32(2)27(36)16-5-7-19(29-24(34)17-10-15-4-6-18(28)12-22(15)37-14-17)21(11-16)30-25(35)26-31-20-8-9-33(3)13-23(20)38-26/h4,6,10,12,16,19,21H,5,7-9,11,13-14H2,1-3H3,(H,29,34)(H,30,35)/t16-,19-,21+/m0/s1 BRGHULUVIQNSDA-NBHGPNQESA-N 35766 cis-1,2-diaminocyclohexane derivative, 5g Coagulation factor X Homo sapiens 35 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.024 10.7270/Q2CC0Z1V 19900814 aid1799342 Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35766&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520924 85856559 ZINC49762040 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63426 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc(O)c3cc(Cl)ccc3n2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C27H31ClN6O4S/c1-33(2)27(38)14-4-6-18(30-24(36)21-12-22(35)16-11-15(28)5-7-17(16)29-21)20(10-14)31-25(37)26-32-19-8-9-34(3)13-23(19)39-26/h5,7,11-12,14,18,20H,4,6,8-10,13H2,1-3H3,(H,29,35)(H,30,36)(H,31,37)/t14-,18-,20+/m0/s1 NFTHBHJSBBKFKQ-ADLFWFRXSA-N 35767 cis-1,2-diaminocyclohexane derivative, 5h Coagulation factor X Homo sapiens 0.43 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.024 10.7270/Q2CC0Z1V 19900814 aid1799342 Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35767&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16661109 85856560 ZINC49762041 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63427 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3ccc(Cl)cc3[nH]c2=O)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C27H31ClN6O4S/c1-33(2)27(38)15-5-7-18(29-23(35)17-10-14-4-6-16(28)12-20(14)30-24(17)36)21(11-15)31-25(37)26-32-19-8-9-34(3)13-22(19)39-26/h4,6,10,12,15,18,21H,5,7-9,11,13H2,1-3H3,(H,29,35)(H,30,36)(H,31,37)/t15-,18-,21+/m0/s1 RQALTJZKSUBDKY-UQASEVPWSA-N 35768 cis-1,2-diaminocyclohexane derivative, 5i Coagulation factor X Homo sapiens 12 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.024 10.7270/Q2CC0Z1V 19900814 aid1799342 Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35768&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520925 85856561 ZINC49757023 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63428 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2nc3ccc(Cl)cc3c(=O)[nH]2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C26H30ClN7O4S/c1-33(2)26(38)13-4-6-17(29-23(36)21-28-16-7-5-14(27)11-15(16)22(35)32-21)19(10-13)30-24(37)25-31-18-8-9-34(3)12-20(18)39-25/h5,7,11,13,17,19H,4,6,8-10,12H2,1-3H3,(H,29,36)(H,30,37)(H,28,32,35)/t13-,17-,19+/m0/s1 JXTLYYJGXOUZGB-SOVGHPHASA-N 35769 cis-1,2-diaminocyclohexane derivative, 5j Coagulation factor X Homo sapiens 1.4 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.024 10.7270/Q2CC0Z1V 19900814 aid1799342 Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35769&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520926 85856562 ZINC49756660 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63429 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)C2=Nc3ccc(Cl)cc3S(=O)(=O)N2)[C@@H](C1)NC(=O)c1nc2CCN(C)Cc2s1 InChI=1S/C25H30ClN7O5S2/c1-32(2)25(36)13-4-6-15(18(10-13)29-23(35)24-30-16-8-9-33(3)12-19(16)39-24)28-22(34)21-27-17-7-5-14(26)11-20(17)40(37,38)31-21/h5,7,11,13,15,18H,4,6,8-10,12H2,1-3H3,(H,27,31)(H,28,34)(H,29,35)/t13-,15-,18+/m0/s1 BPFHOVIJMQSTBH-DHSIGJKJSA-N 35770 cis-1,2-diaminocyclohexane derivative, 5k Coagulation factor X Homo sapiens 4.9 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.024 10.7270/Q2CC0Z1V 19900814 aid1799342 Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35770&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520927 85856563 ZINC49756577 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63430 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2ccc3cc(Cl)ccc3c2)[C@@H](C1)NC(=O)c1nc2CN(C)Cc2s1 InChI=1S/C27H30ClN5O3S/c1-32(2)27(36)18-7-9-20(29-24(34)17-5-4-16-11-19(28)8-6-15(16)10-17)21(12-18)30-25(35)26-31-22-13-33(3)14-23(22)37-26/h4-6,8,10-11,18,20-21H,7,9,12-14H2,1-3H3,(H,29,34)(H,30,35)/t18-,20-,21+/m0/s1 KDVKXSIMMKHVJO-SESVDKBCSA-N 35771 cis-1,2-diaminocyclohexane derivative, 45a Coagulation factor X Homo sapiens 12 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.024 10.7270/Q2CC0Z1V 19900814 aid1799342 Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35771&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520928 85856564 ZINC49757366 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63431 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3ccc(Cl)cc3cn2)[C@@H](C1)NC(=O)c1nc2CN(C)Cc2s1 InChI=1S/C26H29ClN6O3S/c1-32(2)26(36)15-5-7-18(29-23(34)20-9-14-4-6-17(27)8-16(14)11-28-20)19(10-15)30-24(35)25-31-21-12-33(3)13-22(21)37-25/h4,6,8-9,11,15,18-19H,5,7,10,12-13H2,1-3H3,(H,29,34)(H,30,35)/t15-,18-,19+/m0/s1 GZCKMZURFJCTJE-ZYSHUDEJSA-N 35772 cis-1,2-diaminocyclohexane derivative, 45c Coagulation factor X Homo sapiens 9.5 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.024 10.7270/Q2CC0Z1V 19900814 aid1799342 Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35772&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search D14 3IIT 44520929 85856565 ZINC49756541 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 63432 CN(C)C(=O)[C@H]1CC[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)[C@@H](C1)NC(=O)c1nc2CN(C)Cc2s1 InChI=1S/C25H29ClN6O3S/c1-31(2)25(35)13-4-6-17(28-22(33)19-10-14-8-15(26)5-7-16(14)27-19)18(9-13)29-23(34)24-30-20-11-32(3)12-21(20)36-24/h5,7-8,10,13,17-18,27H,4,6,9,11-12H2,1-3H3,(H,28,33)(H,29,34)/t13-,17-,18+/m0/s1 AURBUEBIALGLQY-DOPJRALCSA-N 35773 cis-1,2-diaminocyclohexane derivative, 48 Coagulation factor X Homo sapiens 3.4 7.4 23.00 C Curated from the literature by BindingDB 10.1016/j.bmc.2009.10.024 10.7270/Q2CC0Z1V 19900814 aid1799342 Yoshikawa, K; Kobayashi, S; Nakamoto, Y; Haginoya, N; Komoriya, S; Yoshino, T; Nagata, T; Mochizuki, A; Watanabe, K; Suzuki, M; Kanno, H; Ohta, T Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35773&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44520930 85856566 ZINC49761970 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62442 Cc1cccc(NC(=S)N[C@H]2CCCCN(CC(=O)N3CCCC3)C2=O)c1 InChI=1S/C20H28N4O2S/c1-15-7-6-8-16(13-15)21-20(27)22-17-9-2-3-12-24(19(17)26)14-18(25)23-10-4-5-11-23/h6-8,13,17H,2-5,9-12,14H2,1H3,(H2,21,22,27)/t17-/m0/s1 ROBFJTHBLVFFRU-KRWDZBQOSA-N 26350 (S)-1-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-yl)-3-m-tolylthiourea::1-(3-methylphenyl)-3-[(3S)-2-oxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)azepan-3-yl]thiourea::3-(3-methylphenyl)-1-[(3S)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepan-3-yl]thiourea::3-methylphenyl compound, 1::BMCL196882 Compound 1::CHEMBL198694 Coagulation factor X Homo sapiens 110 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26350&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 25138134 56464787 CHEMBL198694 ZINC28530127 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62443 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)C(C#N)C#N InChI=1S/C25H28N6O3/c1-17-12-18-13-20(7-8-22(18)34-17)28-24(19(14-26)15-27)29-21-6-2-3-11-31(25(21)33)16-23(32)30-9-4-5-10-30/h7-8,12-13,19,21H,2-6,9-11,16H2,1H3,(H,28,29)/t21-/m0/s1 HKKVYLLIDWPQMA-NRFANRHFSA-N 26351 2-methylbenzofuran compound, 2::2-{[(2-methyl-1-benzofuran-5-yl)amino]({[(3S)-2-oxo-1-[2-oxo-2-(pyrrolidin-1-yl)ethyl]azepan-3-yl]amino})methylidene}propanedinitrile::CHEMBL196803 Coagulation factor X Homo sapiens 30 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26351&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91242797 56464788 CHEMBL196803 ZINC34689203 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62444 Cc1cc2cc(ccc2o1)N=C(NC#N)N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O InChI=1S/C23H28N6O3/c1-16-12-17-13-18(7-8-20(17)32-16)26-23(25-15-24)27-19-6-2-3-11-29(22(19)31)14-21(30)28-9-4-5-10-28/h7-8,12-13,19H,2-6,9-11,14H2,1H3,(H2,25,26,27)/t19-/m0/s1 BQUXAJWDRCSKFN-IBGZPJMESA-N 35283 CHEMBL551991::cyanoguanidine, 3 Coagulation factor X Homo sapiens 12 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35283&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search YET 3HPT 44249821 85753359 CHEMBL551991 ZINC43019712 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62445 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)N[N+]([O-])=O InChI=1S/C22H28N6O5/c1-15-12-16-13-17(7-8-19(16)33-15)23-22(25-28(31)32)24-18-6-2-3-11-27(21(18)30)14-20(29)26-9-4-5-10-26/h7-8,12-13,18H,2-6,9-11,14H2,1H3,(H2,23,24,25)/t18-/m0/s1 NEQYJEALGOSBJO-SFHVURJKSA-N 35284 nitroguanidine, 4 Coagulation factor X Homo sapiens 25 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35284&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473068 85753360 ZINC45316209 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62446 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NS(C)(=O)=O InChI=1S/C23H31N5O5S/c1-16-13-17-14-18(8-9-20(17)33-16)24-23(26-34(2,31)32)25-19-7-3-4-12-28(22(19)30)15-21(29)27-10-5-6-11-27/h8-9,13-14,19H,3-7,10-12,15H2,1-2H3,(H2,24,25,26)/t19-/m0/s1 TZESIOICLNCLGQ-IBGZPJMESA-N 35285 sulfonylguanidine, 5 Coagulation factor X Homo sapiens 10 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35285&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473069 85753361 ZINC45318654 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62447 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NS(N)(=O)=O InChI=1S/C22H30N6O5S/c1-15-12-16-13-17(7-8-19(16)33-15)24-22(26-34(23,31)32)25-18-6-2-3-11-28(21(18)30)14-20(29)27-9-4-5-10-27/h7-8,12-13,18H,2-6,9-11,14H2,1H3,(H2,23,31,32)(H2,24,25,26)/t18-/m0/s1 DMMMNEOMZGQUPI-SFHVURJKSA-N 35286 sulfamoylguanidine, 6 Coagulation factor X Homo sapiens 12 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35286&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473070 85753362 ZINC45257008 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62448 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NS(=O)(=O)c1ccccc1 InChI=1S/C28H33N5O5S/c1-20-17-21-18-22(12-13-25(21)38-20)29-28(31-39(36,37)23-9-3-2-4-10-23)30-24-11-5-6-16-33(27(24)35)19-26(34)32-14-7-8-15-32/h2-4,9-10,12-13,17-18,24H,5-8,11,14-16,19H2,1H3,(H2,29,30,31)/t24-/m0/s1 IWEOWGPCEMNNLJ-DEOSSOPVSA-N 35287 sulfonylguanidine, 7 Coagulation factor X Homo sapiens 24 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35287&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473071 85753363 ZINC49745409 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62449 CC(=O)NC(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1ccc2oc(C)cc2c1 InChI=1S/C24H31N5O4/c1-16-13-18-14-19(8-9-21(18)33-16)26-24(25-17(2)30)27-20-7-3-4-12-29(23(20)32)15-22(31)28-10-5-6-11-28/h8-9,13-14,20H,3-7,10-12,15H2,1-2H3,(H2,25,26,27,30)/t20-/m0/s1 WHZAETQIRWBIBK-FQEVSTJZSA-N 35288 acetylguanidine, 8 Coagulation factor X Homo sapiens 17 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35288&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473072 85753364 ZINC45252895 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62450 CCOC(=O)NC(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1ccc2oc(C)cc2c1 InChI=1S/C25H33N5O5/c1-3-34-25(33)28-24(26-19-9-10-21-18(15-19)14-17(2)35-21)27-20-8-4-5-13-30(23(20)32)16-22(31)29-11-6-7-12-29/h9-10,14-15,20H,3-8,11-13,16H2,1-2H3,(H2,26,27,28,33)/t20-/m0/s1 KLVFLJJGNUCXCE-FQEVSTJZSA-N 35289 ethoxylcarbonylguanidine, 9 Coagulation factor X Homo sapiens 32 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35289&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473073 85753365 ZINC45253450 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62451 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(N)=O InChI=1S/C23H30N6O4/c1-15-12-16-13-17(7-8-19(16)33-15)25-23(27-22(24)32)26-18-6-2-3-11-29(21(18)31)14-20(30)28-9-4-5-10-28/h7-8,12-13,18H,2-6,9-11,14H2,1H3,(H4,24,25,26,27,32)/t18-/m0/s1 NVDVIJNEIDIGBB-SFHVURJKSA-N 35290 carbamoylguanidine, 10 Coagulation factor X Homo sapiens 28 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35290&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473074 85753366 ZINC45245258 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62452 CN(C)C(=O)NC(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1ccc2oc(C)cc2c1 InChI=1S/C25H34N6O4/c1-17-14-18-15-19(9-10-21(18)35-17)26-24(28-25(34)29(2)3)27-20-8-4-5-13-31(23(20)33)16-22(32)30-11-6-7-12-30/h9-10,14-15,20H,4-8,11-13,16H2,1-3H3,(H2,26,27,28,34)/t20-/m0/s1 DXESZQKHAGLMMX-FQEVSTJZSA-N 35291 carbamoylguanidine, 11 Coagulation factor X Homo sapiens 15 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35291&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473075 85753367 ZINC45245974 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62453 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1ccccc1 InChI=1S/C29H33N5O4/c1-20-17-22-18-23(12-13-25(22)38-20)30-29(32-27(36)21-9-3-2-4-10-21)31-24-11-5-6-16-34(28(24)37)19-26(35)33-14-7-8-15-33/h2-4,9-10,12-13,17-18,24H,5-8,11,14-16,19H2,1H3,(H2,30,31,32,36)/t24-/m0/s1 GSMFCURCLGIFMR-DEOSSOPVSA-N 35292 benzoylguanidine, 12 Coagulation factor X Homo sapiens 6 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35292&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473076 85753368 ZINC40874678 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62454 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1cccc(Cl)c1 InChI=1S/C29H32ClN5O4/c1-19-15-21-17-23(10-11-25(21)39-19)31-29(33-27(37)20-7-6-8-22(30)16-20)32-24-9-2-3-14-35(28(24)38)18-26(36)34-12-4-5-13-34/h6-8,10-11,15-17,24H,2-5,9,12-14,18H2,1H3,(H2,31,32,33,37)/t24-/m0/s1 DAYOFUOSHATVFV-DEOSSOPVSA-N 35293 benzoylguanidine, 13 Coagulation factor X Homo sapiens 7 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35293&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473077 85753369 ZINC49678269 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62455 COC(=O)c1cccc(c1)C(=O)NC(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1ccc2oc(C)cc2c1 InChI=1S/C31H35N5O6/c1-20-16-23-18-24(11-12-26(23)42-20)32-31(34-28(38)21-8-7-9-22(17-21)30(40)41-2)33-25-10-3-4-15-36(29(25)39)19-27(37)35-13-5-6-14-35/h7-9,11-12,16-18,25H,3-6,10,13-15,19H2,1-2H3,(H2,32,33,34,38)/t25-/m0/s1 LAMHIKNPNKNLPR-VWLOTQADSA-N 35294 benzoylguanidine, 14 Coagulation factor X Homo sapiens 5 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35294&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473078 85753370 ZINC49695332 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62456 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1cccc(c1)C(=O)ON InChI=1S/C30H34N6O6/c1-19-15-22-17-23(10-11-25(22)41-19)32-30(34-27(38)20-7-6-8-21(16-20)29(40)42-31)33-24-9-2-3-14-36(28(24)39)18-26(37)35-12-4-5-13-35/h6-8,10-11,15-17,24H,2-5,9,12-14,18,31H2,1H3,(H2,32,33,34,38)/t24-/m0/s1 GQIBAUJOKPCUFS-DEOSSOPVSA-N 35295 benzoylguanidine, 15 Coagulation factor X Homo sapiens 18 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35295&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473079 85753371 ZINC70707226 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62457 CN(C)OC(=O)c1cccc(c1)C(=O)NC(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1ccc2oc(C)cc2c1 InChI=1S/C32H38N6O6/c1-21-17-24-19-25(12-13-27(24)43-21)33-32(35-29(40)22-9-8-10-23(18-22)31(42)44-36(2)3)34-26-11-4-5-16-38(30(26)41)20-28(39)37-14-6-7-15-37/h8-10,12-13,17-19,26H,4-7,11,14-16,20H2,1-3H3,(H2,33,34,35,40)/t26-/m0/s1 XXBBMGRLEMRZBE-SANMLTNESA-N 35296 benzoylguanidine, 16 Coagulation factor X Homo sapiens 10 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35296&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473080 85753372 ZINC70707247 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62458 COC(=O)c1ccc(cc1)C(=O)NC(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1ccc2oc(C)cc2c1 InChI=1S/C31H35N5O6/c1-20-17-23-18-24(12-13-26(23)42-20)32-31(34-28(38)21-8-10-22(11-9-21)30(40)41-2)33-25-7-3-4-16-36(29(25)39)19-27(37)35-14-5-6-15-35/h8-13,17-18,25H,3-7,14-16,19H2,1-2H3,(H2,32,33,34,38)/t25-/m0/s1 WMBQKZMDBWGVFW-VWLOTQADSA-N 35297 benzoylguanidine, 17 Coagulation factor X Homo sapiens 6 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35297&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473081 85753373 ZINC49722532 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62459 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1ccc(cc1)C(O)=O InChI=1S/C30H33N5O6/c1-19-16-22-17-23(11-12-25(22)41-19)31-30(33-27(37)20-7-9-21(10-8-20)29(39)40)32-24-6-2-3-15-35(28(24)38)18-26(36)34-13-4-5-14-34/h7-12,16-17,24H,2-6,13-15,18H2,1H3,(H,39,40)(H2,31,32,33,37)/t24-/m0/s1 QRLFWIYNTVCZJR-DEOSSOPVSA-N 35298 benzoylguanidine, 18 Coagulation factor X Homo sapiens 2 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35298&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473082 85753374 ZINC49722561 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62460 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1ccc(cc1)C(=O)ON InChI=1S/C30H34N6O6/c1-19-16-22-17-23(11-12-25(22)41-19)32-30(34-27(38)20-7-9-21(10-8-20)29(40)42-31)33-24-6-2-3-15-36(28(24)39)18-26(37)35-13-4-5-14-35/h7-12,16-17,24H,2-6,13-15,18,31H2,1H3,(H2,32,33,34,38)/t24-/m0/s1 YPLOUJCUKOTLBQ-DEOSSOPVSA-N 35299 benzoylguanidine, 19 Coagulation factor X Homo sapiens 3 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35299&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473083 85753375 ZINC70707272 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62461 CN(C)OC(=O)c1ccc(cc1)C(=O)NC(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1ccc2oc(C)cc2c1 InChI=1S/C32H38N6O6/c1-21-18-24-19-25(13-14-27(24)43-21)33-32(35-29(40)22-9-11-23(12-10-22)31(42)44-36(2)3)34-26-8-4-5-17-38(30(26)41)20-28(39)37-15-6-7-16-37/h9-14,18-19,26H,4-8,15-17,20H2,1-3H3,(H2,33,34,35,40)/t26-/m0/s1 PBDARTXWKVUCQO-SANMLTNESA-N 35300 benzoylguanidine, 20 Coagulation factor X Homo sapiens 3 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35300&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473084 85753376 ZINC70707287 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62462 COC(=O)c1ccc(nc1)C(=O)NC(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1ccc2oc(C)cc2c1 InChI=1S/C30H34N6O6/c1-19-15-21-16-22(9-11-25(21)42-19)32-30(34-27(38)23-10-8-20(17-31-23)29(40)41-2)33-24-7-3-4-14-36(28(24)39)18-26(37)35-12-5-6-13-35/h8-11,15-17,24H,3-7,12-14,18H2,1-2H3,(H2,32,33,34,38)/t24-/m0/s1 OXNNNLQIYQFBKE-DEOSSOPVSA-N 35301 picolinoyl guanidine, 21 Coagulation factor X Homo sapiens 55 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35301&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473085 85753377 ZINC70707307 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62463 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1cccnc1 InChI=1S/C28H32N6O4/c1-19-15-21-16-22(9-10-24(21)38-19)30-28(32-26(36)20-7-6-11-29-17-20)31-23-8-2-3-14-34(27(23)37)18-25(35)33-12-4-5-13-33/h6-7,9-11,15-17,23H,2-5,8,12-14,18H2,1H3,(H2,30,31,32,36)/t23-/m0/s1 GNYXHJVKEWBHAI-QHCPKHFHSA-N 35302 nicotinoyl guanidine, 22 Coagulation factor X Homo sapiens 4 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35302&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search MBM 3K9X 44473086 85753378 ZINC44460288 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62464 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1ccncc1 InChI=1S/C28H32N6O4/c1-19-16-21-17-22(7-8-24(21)38-19)30-28(32-26(36)20-9-11-29-12-10-20)31-23-6-2-3-15-34(27(23)37)18-25(35)33-13-4-5-14-33/h7-12,16-17,23H,2-6,13-15,18H2,1H3,(H2,30,31,32,36)/t23-/m0/s1 XADNBXRMAXRZGY-QHCPKHFHSA-N 35303 isonicotinoyl guanidine, 23 Coagulation factor X Homo sapiens 3 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35303&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473087 85753379 ZINC45245922 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62465 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1cnccn1 InChI=1S/C27H31N7O4/c1-18-14-19-15-20(7-8-23(19)38-18)30-27(32-25(36)22-16-28-9-10-29-22)31-21-6-2-3-13-34(26(21)37)17-24(35)33-11-4-5-12-33/h7-10,14-16,21H,2-6,11-13,17H2,1H3,(H2,30,31,32,36)/t21-/m0/s1 QCFANUTYFQTUHC-NRFANRHFSA-N 35304 heteroaroylguanidine, 24 Coagulation factor X Homo sapiens 50 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35304&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473088 85753380 ZINC45252951 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62466 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1ccoc1 InChI=1S/C27H31N5O5/c1-18-14-20-15-21(7-8-23(20)37-18)28-27(30-25(34)19-9-13-36-17-19)29-22-6-2-3-12-32(26(22)35)16-24(33)31-10-4-5-11-31/h7-9,13-15,17,22H,2-6,10-12,16H2,1H3,(H2,28,29,30,34)/t22-/m0/s1 BNXJYMMHJNYEHE-QFIPXVFZSA-N 35305 heteroaroylguanidine, 25 Coagulation factor X Homo sapiens 4 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35305&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473089 85753381 ZINC45320970 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62467 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1ccsc1 InChI=1S/C27H31N5O4S/c1-18-14-20-15-21(7-8-23(20)36-18)28-27(30-25(34)19-9-13-37-17-19)29-22-6-2-3-12-32(26(22)35)16-24(33)31-10-4-5-11-31/h7-9,13-15,17,22H,2-6,10-12,16H2,1H3,(H2,28,29,30,34)/t22-/m0/s1 HQYPQJGCRYBALL-QFIPXVFZSA-N 35306 heteroaroylguanidine, 26 Coagulation factor X Homo sapiens 6 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35306&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473090 85753382 ZINC45253448 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62468 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1cnn(C)c1 InChI=1S/C27H33N7O4/c1-18-13-19-14-21(8-9-23(19)38-18)29-27(31-25(36)20-15-28-32(2)16-20)30-22-7-3-4-12-34(26(22)37)17-24(35)33-10-5-6-11-33/h8-9,13-16,22H,3-7,10-12,17H2,1-2H3,(H2,29,30,31,36)/t22-/m0/s1 NDGAWDDCHYCUAK-QFIPXVFZSA-N 35307 heteroaroylguanidine, 27 Coagulation factor X Homo sapiens 9 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35307&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473091 85753383 ZINC45245500 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62469 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1nnn(C)n1 InChI=1S/C25H31N9O4/c1-16-13-17-14-18(8-9-20(17)38-16)26-25(28-23(36)22-29-31-32(2)30-22)27-19-7-3-4-12-34(24(19)37)15-21(35)33-10-5-6-11-33/h8-9,13-14,19H,3-7,10-12,15H2,1-2H3,(H2,26,27,28,36)/t19-/m0/s1 IXWTWZLZTBMNNQ-IBGZPJMESA-N 35308 tetrazoloyl guanidine, 28 Coagulation factor X Homo sapiens 56 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35308&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473092 85753384 ZINC45321006 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62470 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1ccc[n+]([O-])c1 InChI=1S/C28H32N6O5/c1-19-15-21-16-22(9-10-24(21)39-19)29-28(31-26(36)20-7-6-14-34(38)17-20)30-23-8-2-3-13-33(27(23)37)18-25(35)32-11-4-5-12-32/h6-7,9-10,14-17,23H,2-5,8,11-13,18H2,1H3,(H2,29,30,31,36)/t23-/m0/s1 LBOFATLQBXVRSA-QHCPKHFHSA-N 35309 nicotinoyl guanidine, 29 Coagulation factor X Homo sapiens 10 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35309&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473093 85753385 ZINC49677716 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62471 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1cncc(c1)C(N)=O InChI=1S/C29H33N7O5/c1-18-12-19-14-22(7-8-24(19)41-18)32-29(34-27(39)21-13-20(26(30)38)15-31-16-21)33-23-6-2-3-11-36(28(23)40)17-25(37)35-9-4-5-10-35/h7-8,12-16,23H,2-6,9-11,17H2,1H3,(H2,30,38)(H2,32,33,34,39)/t23-/m0/s1 IBABQVTVKGTVDW-QHCPKHFHSA-N 35310 nicotinoyl guanidine, 30 Coagulation factor X Homo sapiens 17 7.4 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35310&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473094 85753386 ZINC49722563 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62472 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1ccc(C)nc1 InChI=1S/C29H34N6O4/c1-19-8-9-21(17-30-19)27(37)33-29(31-23-10-11-25-22(16-23)15-20(2)39-25)32-24-7-3-4-14-35(28(24)38)18-26(36)34-12-5-6-13-34/h8-11,15-17,24H,3-7,12-14,18H2,1-2H3,(H2,31,32,33,37)/t24-/m0/s1 NPLZSLFSOASJNF-DEOSSOPVSA-N 35311 nicotinoyl guanidine, 31 Coagulation factor X Homo sapiens 4 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35311&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473095 85753387 ZINC45245171 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62473 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1ccc(Cl)nc1 InChI=1S/C28H31ClN6O4/c1-18-14-20-15-21(8-9-23(20)39-18)31-28(33-26(37)19-7-10-24(29)30-16-19)32-22-6-2-3-13-35(27(22)38)17-25(36)34-11-4-5-12-34/h7-10,14-16,22H,2-6,11-13,17H2,1H3,(H2,31,32,33,37)/t22-/m0/s1 QOJWZANXROFNQS-QFIPXVFZSA-N 35312 nicotinoyl guanidine, 32 Coagulation factor X Homo sapiens 5 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35312&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473096 85753388 ZINC49694448 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62474 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1ccc(nc1)C(O)=O InChI=1S/C29H32N6O6/c1-18-14-20-15-21(8-10-24(20)41-18)31-29(33-26(37)19-7-9-23(28(39)40)30-16-19)32-22-6-2-3-13-35(27(22)38)17-25(36)34-11-4-5-12-34/h7-10,14-16,22H,2-6,11-13,17H2,1H3,(H,39,40)(H2,31,32,33,37)/t22-/m0/s1 SMLNDPGQWMLXAK-QFIPXVFZSA-N 35313 nicotinoyl guanidine, 33 Coagulation factor X Homo sapiens 3.3 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35313&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473097 85753389 ZINC70707384 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62475 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)NC(=O)c1ccc(nc1)C(N)=O InChI=1S/C29H33N7O5/c1-18-14-20-15-21(8-10-24(20)41-18)32-29(34-27(39)19-7-9-22(26(30)38)31-16-19)33-23-6-2-3-13-36(28(23)40)17-25(37)35-11-4-5-12-35/h7-10,14-16,23H,2-6,11-13,17H2,1H3,(H2,30,38)(H2,32,33,34,39)/t23-/m0/s1 VUXWOZNVRFWGIQ-QHCPKHFHSA-N 35314 nicotinoyl guanidine, 34 Coagulation factor X Homo sapiens 12 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35314&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473098 85753390 ZINC70707390 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62476 CNC(=O)c1ccc(cn1)C(=O)NC(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1ccc2oc(C)cc2c1 InChI=1S/C30H35N7O5/c1-19-15-21-16-22(9-11-25(21)42-19)33-30(35-27(39)20-8-10-23(32-17-20)28(40)31-2)34-24-7-3-4-14-37(29(24)41)18-26(38)36-12-5-6-13-36/h8-11,15-17,24H,3-7,12-14,18H2,1-2H3,(H,31,40)(H2,33,34,35,39)/t24-/m0/s1 IFHTTXSATPHTDC-DEOSSOPVSA-N 35315 nicotinoyl guanidine, 35 Coagulation factor X Homo sapiens 6 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35315&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473099 85753391 ZINC70707397 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 62477 CN(C)C(=O)c1ccc(cn1)C(=O)NC(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)=Nc1ccc2oc(C)cc2c1 InChI=1S/C31H37N7O5/c1-20-16-22-17-23(10-12-26(22)43-20)33-31(35-28(40)21-9-11-24(32-18-21)29(41)36(2)3)34-25-8-4-5-15-38(30(25)42)19-27(39)37-13-6-7-14-37/h9-12,16-18,25H,4-8,13-15,19H2,1-3H3,(H2,33,34,35,40)/t25-/m0/s1 YLSKCQOVDOZHTQ-VWLOTQADSA-N 35316 BMS-344577 Coagulation factor X Homo sapiens 9 25.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.10.084 10.7270/Q2Z899R2 19896847 aid1799306 Shi, Y; Li, C; O'Connor, SP; Zhang, J; Shi, M; Bisaha, SN; Wang, Y; Sitkoff, D; Pudzianowski, AT; Huang, C; Klei, HE; Kish, K; Yanchunas, J; Liu, EC; Hartl, KS; Seiler, SM; Steinbacher, TE; Schumacher, WA; Atwal, KS; Stein, PD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35316&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44473100 85753392 ZINC03966566 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154787 NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)C2CCCN2C(=O)Nc2ccc(Br)cc2)c(F)c1 InChI=1S/C24H22BrFN4O4S/c25-16-8-10-17(11-9-16)28-24(32)30-13-3-5-21(30)23(31)29-20-12-7-15(14-19(20)26)18-4-1-2-6-22(18)35(27,33)34/h1-2,4,6-12,14,21H,3,5,13H2,(H,28,32)(H,29,31)(H2,27,33,34) HICSFOWYIPJAEW-UHFFFAOYSA-N 81681 P1 Phenyl Ring, 22 Coagulation factor X Homo sapiens 33 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81681&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21025990 131342255 ZINC70463352 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154788 NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)[C@H]2CCCN2C(=O)Nc2ccc(Cl)cc2)c(F)c1 InChI=1S/C24H22ClFN4O4S/c25-16-8-10-17(11-9-16)28-24(32)30-13-3-5-21(30)23(31)29-20-12-7-15(14-19(20)26)18-4-1-2-6-22(18)35(27,33)34/h1-2,4,6-12,14,21H,3,5,13H2,(H,28,32)(H,29,31)(H2,27,33,34)/t21-/m1/s1 BTWQGZKVIXMIOP-OAQYLSRUSA-N 50328725 (R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)pyrrolidine-1,2-dicarboxamide::4-Substituted Pyrrolidine Ring, 1::CHEMBL1271371::P1 Phenyl Ring, 23 Coagulation factor X Homo sapiens 36 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50328725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50328725&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16749087 123107840 CHEMBL1271371 ZINC34272828 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154789 Cc1ccc(NC(=O)N2CCCC2C(=O)Nc2ccc(cc2F)-c2ccccc2S(N)(=O)=O)cc1 InChI=1S/C25H25FN4O4S/c1-16-8-11-18(12-9-16)28-25(32)30-14-4-6-22(30)24(31)29-21-13-10-17(15-20(21)26)19-5-2-3-7-23(19)35(27,33)34/h2-3,5,7-13,15,22H,4,6,14H2,1H3,(H,28,32)(H,29,31)(H2,27,33,34) PQFRCLDNWFFIGY-UHFFFAOYSA-N 81682 P1 Phenyl Ring, 24 Coagulation factor X Homo sapiens 389 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81682&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21025982 131342256 ZINC70463354 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154790 Cc1ccc(NC(=O)N2CCCC2C(=O)Nc2ccc(cc2F)-c2ccccc2S(N)(=O)=O)cc1F InChI=1S/C25H24F2N4O4S/c1-15-8-10-17(14-19(15)26)29-25(33)31-12-4-6-22(31)24(32)30-21-11-9-16(13-20(21)27)18-5-2-3-7-23(18)36(28,34)35/h2-3,5,7-11,13-14,22H,4,6,12H2,1H3,(H,29,33)(H,30,32)(H2,28,34,35) XGFPXLVJXYOMIM-UHFFFAOYSA-N 81683 P1 Phenyl Ring, 25 Coagulation factor X Homo sapiens 516 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81683&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21025984 131342257 ZINC70463356 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154791 COc1ccc(NC(=O)N2CCCC2C(=O)Nc2ccc(cc2F)-c2ccccc2S(N)(=O)=O)cc1 InChI=1S/C25H25FN4O5S/c1-35-18-11-9-17(10-12-18)28-25(32)30-14-4-6-22(30)24(31)29-21-13-8-16(15-20(21)26)19-5-2-3-7-23(19)36(27,33)34/h2-3,5,7-13,15,22H,4,6,14H2,1H3,(H,28,32)(H,29,31)(H2,27,33,34) CKSMADBNTANRQG-UHFFFAOYSA-N 81684 P1 Phenyl Ring, 26 Coagulation factor X Homo sapiens 873 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81684&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21025980 131342258 ZINC70463358 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154792 NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)C2CCCN2C(=O)Nc2ccccc2)c(F)c1 InChI=1S/C24H23FN4O4S/c25-19-15-16(18-9-4-5-11-22(18)34(26,32)33)12-13-20(19)28-23(30)21-10-6-14-29(21)24(31)27-17-7-2-1-3-8-17/h1-5,7-9,11-13,15,21H,6,10,14H2,(H,27,31)(H,28,30)(H2,26,32,33) OBQZKTHLYMINJK-UHFFFAOYSA-N 81685 P1 Phenyl Ring, 27 Coagulation factor X Homo sapiens 951 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81685&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21025981 131342259 ZINC70463360 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154793 NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)C2CCCN2C(=O)Nc2cccc(Cl)c2)c(F)c1 InChI=1S/C24H22ClFN4O4S/c25-16-5-3-6-17(14-16)28-24(32)30-12-4-8-21(30)23(31)29-20-11-10-15(13-19(20)26)18-7-1-2-9-22(18)35(27,33)34/h1-3,5-7,9-11,13-14,21H,4,8,12H2,(H,28,32)(H,29,31)(H2,27,33,34) WMNYLFGSVLDMGP-UHFFFAOYSA-N 81686 P1 Phenyl Ring, 28 Coagulation factor X Homo sapiens >4000 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81686&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 54592291 131342260 ZINC70463362 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154794 NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)C2CCCN2C(=O)Nc2ccc(Cl)c(Cl)c2)c(F)c1 InChI=1S/C24H21Cl2FN4O4S/c25-17-9-8-15(13-18(17)26)29-24(33)31-11-3-5-21(31)23(32)30-20-10-7-14(12-19(20)27)16-4-1-2-6-22(16)36(28,34)35/h1-2,4,6-10,12-13,21H,3,5,11H2,(H,29,33)(H,30,32)(H2,28,34,35) BGWOZYOVFMBNNR-UHFFFAOYSA-N 81687 P1 Phenyl Ring, 29 Coagulation factor X Homo sapiens >4000 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81687&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 54592292 131342261 ZINC70463364 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154795 CCc1ccc(NC(=O)N2CCCC2C(=O)Nc2ccc(cc2F)-c2ccccc2S(N)(=O)=O)cc1 InChI=1S/C26H27FN4O4S/c1-2-17-9-12-19(13-10-17)29-26(33)31-15-5-7-23(31)25(32)30-22-14-11-18(16-21(22)27)20-6-3-4-8-24(20)36(28,34)35/h3-4,6,8-14,16,23H,2,5,7,15H2,1H3,(H,29,33)(H,30,32)(H2,28,34,35) LLSZMIFWLGZGOT-UHFFFAOYSA-N 81688 P1 Phenyl Ring, 30 Coagulation factor X Homo sapiens >4000 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81688&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 54592293 131342262 ZINC70463366 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154796 NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)C2CCCN2C(=O)Nc2ccc(cc2)C(F)(F)F)c(F)c1 InChI=1S/C25H22F4N4O4S/c26-19-14-15(18-4-1-2-6-22(18)38(30,36)37)7-12-20(19)32-23(34)21-5-3-13-33(21)24(35)31-17-10-8-16(9-11-17)25(27,28)29/h1-2,4,6-12,14,21H,3,5,13H2,(H,31,35)(H,32,34)(H2,30,36,37) ZBVYHFLQOVUOMR-UHFFFAOYSA-N 81689 P1 Phenyl Ring, 31 Coagulation factor X Homo sapiens >4000 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81689&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 54592294 131342263 ZINC70463368 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154797 COc1cccc(NC(=O)N2CCCC2C(=O)Nc2ccc(cc2F)-c2ccccc2S(N)(=O)=O)c1 InChI=1S/C25H25FN4O5S/c1-35-18-7-4-6-17(15-18)28-25(32)30-13-5-9-22(30)24(31)29-21-12-11-16(14-20(21)26)19-8-2-3-10-23(19)36(27,33)34/h2-4,6-8,10-12,14-15,22H,5,9,13H2,1H3,(H,28,32)(H,29,31)(H2,27,33,34) GCPPDHNFHIHODC-UHFFFAOYSA-N 81690 P1 Phenyl Ring, 32 Coagulation factor X Homo sapiens >4000 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81690&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 54592295 131342264 ZINC70463370 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154798 NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)C2CCCN2C(=O)Nc2ccccc2F)c(F)c1 InChI=1S/C24H22F2N4O4S/c25-17-7-2-3-8-19(17)29-24(32)30-13-5-9-21(30)23(31)28-20-12-11-15(14-18(20)26)16-6-1-4-10-22(16)35(27,33)34/h1-4,6-8,10-12,14,21H,5,9,13H2,(H,28,31)(H,29,32)(H2,27,33,34) HLAWUHGLWHBBEM-UHFFFAOYSA-N 81691 P1 Phenyl Ring, 33 Coagulation factor X Homo sapiens >4000 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81691&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 54592296 131342265 ZINC70463372 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154799 NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)[C@H]2CCCN2C(=O)Nc2ccc(Cl)cc2)c(F)c1 InChI=1S/C24H22ClFN4O4S/c25-16-8-10-17(11-9-16)28-24(32)30-13-3-5-21(30)23(31)29-20-12-7-15(14-19(20)26)18-4-1-2-6-22(18)35(27,33)34/h1-2,4,6-12,14,21H,3,5,13H2,(H,28,32)(H,29,31)(H2,27,33,34)/t21-/m1/s1 BTWQGZKVIXMIOP-OAQYLSRUSA-N 50328725 (R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)pyrrolidine-1,2-dicarboxamide::4-Substituted Pyrrolidine Ring, 1::CHEMBL1271371::P1 Phenyl Ring, 23 Coagulation factor X Homo sapiens 18 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50328725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50328725&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16749087 123107840 CHEMBL1271371 ZINC34272828 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154800 CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)[C@H]2C[C@@H](O)CN2C(=O)Nc2ccc(Cl)cc2)c(F)c1 InChI=1S/C25H23ClFN3O5S/c1-36(34,35)23-5-3-2-4-19(23)15-6-11-21(20(27)12-15)29-24(32)22-13-18(31)14-30(22)25(33)28-17-9-7-16(26)8-10-17/h2-12,18,22,31H,13-14H2,1H3,(H,28,33)(H,29,32)/t18-,22-/m1/s1 SAWKEKRFHJVBDD-XMSQKQJNSA-N 50328728 (2R,4R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl)-4-hydroxypyrrolidine-1,2-dicarboxamide::4-Substituted Pyrrolidine Ring, 13::4-Substituted Pyrrolidine Ring, 15::CHEMBL1269832 Coagulation factor X Homo sapiens 0.38 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50328728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50328728&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16748993 123107843 CHEMBL1269832 ZINC64527083 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154802 CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)[C@H]2C[C@@H](O)CN2C(=O)Nc2ccc(Cl)cc2)c(F)c1 InChI=1S/C25H23ClFN3O5S/c1-36(34,35)23-5-3-2-4-19(23)15-6-11-21(20(27)12-15)29-24(32)22-13-18(31)14-30(22)25(33)28-17-9-7-16(26)8-10-17/h2-12,18,22,31H,13-14H2,1H3,(H,28,33)(H,29,32)/t18-,22-/m1/s1 SAWKEKRFHJVBDD-XMSQKQJNSA-N 50328728 (2R,4R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl)-4-hydroxypyrrolidine-1,2-dicarboxamide::4-Substituted Pyrrolidine Ring, 13::4-Substituted Pyrrolidine Ring, 15::CHEMBL1269832 Coagulation factor X Homo sapiens 6.1 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50328728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50328728&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16748993 123107843 CHEMBL1269832 ZINC64527083 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154803 CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)[C@H]2CC(F)CN2C(=O)Nc2ccc(Cl)cc2)c(F)c1 InChI=1S/C25H22ClF2N3O4S/c1-36(34,35)23-5-3-2-4-19(23)15-6-11-21(20(28)12-15)30-24(32)22-13-17(27)14-31(22)25(33)29-18-9-7-16(26)8-10-18/h2-12,17,22H,13-14H2,1H3,(H,29,33)(H,30,32)/t17?,22-/m1/s1 NXKSHXRRVMZPFR-IVAFLUGOSA-N 81693 4-Substituted Pyrrolidine Ring, 16::4-Substituted Pyrrolidine Ring, 17 Coagulation factor X Homo sapiens 7.0 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81693&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 54592298 131342267 ZINC70463376 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154804 CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)[C@H]2CC(F)CN2C(=O)Nc2ccc(Cl)cc2)c(F)c1 InChI=1S/C25H22ClF2N3O4S/c1-36(34,35)23-5-3-2-4-19(23)15-6-11-21(20(28)12-15)30-24(32)22-13-17(27)14-31(22)25(33)29-18-9-7-16(26)8-10-18/h2-12,17,22H,13-14H2,1H3,(H,29,33)(H,30,32)/t17?,22-/m1/s1 NXKSHXRRVMZPFR-IVAFLUGOSA-N 81693 4-Substituted Pyrrolidine Ring, 16::4-Substituted Pyrrolidine Ring, 17 Coagulation factor X Homo sapiens 1.2 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81693&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 54592298 131342267 ZINC70463376 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154805 CO[C@@H]1C[C@@H](N(C1)C(=O)Nc1ccc(Cl)cc1)C(=O)Nc1ccc(cc1F)-c1ccccc1S(C)(=O)=O InChI=1S/C26H25ClFN3O5S/c1-36-19-14-23(31(15-19)26(33)29-18-10-8-17(27)9-11-18)25(32)30-22-12-7-16(13-21(22)28)20-5-3-4-6-24(20)37(2,34)35/h3-13,19,23H,14-15H2,1-2H3,(H,29,33)(H,30,32)/t19-,23-/m1/s1 QBTQRXKLWHEJQY-AUSIDOKSSA-N 50328726 (2R,4R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl)-4-methoxypyrrolidine-1,2-dicarboxamide::(2R,4R)-N~1~-(4-CHLOROPHENYL)-N~2~-[3-FLUORO-2'-(METHYLSULFONYL)BIPHENYL-4-YL]-4-METHOXYPYRROLIDINE-1,2-DICARBOXAMIDE::4-Substituted Pyrrolidine Ring, 18::4-Substituted Pyrrolidine Ring, 19::CHEMBL1229814 Coagulation factor X Homo sapiens 0.16 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50328726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50328726&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 237 2PR3 16741235 123107841 CHEMBL1229814 ZINC03916351 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154806 CO[C@@H]1C[C@@H](N(C1)C(=O)Nc1ccc(Cl)cc1)C(=O)Nc1ccc(cc1F)-c1ccccc1S(C)(=O)=O InChI=1S/C26H25ClFN3O5S/c1-36-19-14-23(31(15-19)26(33)29-18-10-8-17(27)9-11-18)25(32)30-22-12-7-16(13-21(22)28)20-5-3-4-6-24(20)37(2,34)35/h3-13,19,23H,14-15H2,1-2H3,(H,29,33)(H,30,32)/t19-,23-/m1/s1 QBTQRXKLWHEJQY-AUSIDOKSSA-N 50328726 (2R,4R)-N1-(4-chlorophenyl)-N2-(3-fluoro-2'-(methylsulfonyl)biphenyl-4-yl)-4-methoxypyrrolidine-1,2-dicarboxamide::(2R,4R)-N~1~-(4-CHLOROPHENYL)-N~2~-[3-FLUORO-2'-(METHYLSULFONYL)BIPHENYL-4-YL]-4-METHOXYPYRROLIDINE-1,2-DICARBOXAMIDE::4-Substituted Pyrrolidine Ring, 18::4-Substituted Pyrrolidine Ring, 19::CHEMBL1229814 Coagulation factor X Homo sapiens 1.7 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50328726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50328726&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 237 2PR3 16741235 123107841 CHEMBL1229814 ZINC03916351 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154807 CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)[C@H]2CC(=O)CN2C(=O)Nc2ccc(Cl)cc2)c(F)c1 InChI=1S/C25H21ClFN3O5S/c1-36(34,35)23-5-3-2-4-19(23)15-6-11-21(20(27)12-15)29-24(32)22-13-18(31)14-30(22)25(33)28-17-9-7-16(26)8-10-17/h2-12,22H,13-14H2,1H3,(H,28,33)(H,29,32)/t22-/m1/s1 DRENYSDHQSXSTO-JOCHJYFZSA-N 81695 4-Substituted Pyrrolidine Ring, 20 Coagulation factor X Homo sapiens 2.9 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81695&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16749189 131342269 ZINC70463377 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154808 CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)[C@H]2CC(F)(F)CN2C(=O)Nc2ccc(Cl)cc2)c(F)c1 InChI=1S/C25H21ClF3N3O4S/c1-37(35,36)22-5-3-2-4-18(22)15-6-11-20(19(27)12-15)31-23(33)21-13-25(28,29)14-32(21)24(34)30-17-9-7-16(26)8-10-17/h2-12,21H,13-14H2,1H3,(H,30,34)(H,31,33)/t21-/m1/s1 JEXAFZJMDHOQNW-OAQYLSRUSA-N 81696 4-Substituted Pyrrolidine Ring, 21 Coagulation factor X Homo sapiens 5.0 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81696&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 16749190 131342270 ZINC70463378 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154809 CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)[C@H]2CC(O)CN2C(=O)Nc2ccc(Cl)cn2)c(F)c1 InChI=1S/C24H22ClFN4O5S/c1-36(34,35)21-5-3-2-4-17(21)14-6-8-19(18(26)10-14)28-23(32)20-11-16(31)13-30(20)24(33)29-22-9-7-15(25)12-27-22/h2-10,12,16,20,31H,11,13H2,1H3,(H,28,32)(H,27,29,33)/t16?,20-/m1/s1 WVDZAJWNFOWGTG-OTOKDRCRSA-N 81697 4-Substituted Pyrrolidine Ring, 34 Coagulation factor X Homo sapiens 4.3 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81697&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 54592299 131342271 ZINC70463380 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154810 COC1C[C@@H](N(C1)C(=O)Nc1ccc(Cl)cn1)C(=O)Nc1ccc(cc1F)-c1ccccc1S(C)(=O)=O InChI=1S/C25H24ClFN4O5S/c1-36-17-12-21(31(14-17)25(33)30-23-10-8-16(26)13-28-23)24(32)29-20-9-7-15(11-19(20)27)18-5-3-4-6-22(18)37(2,34)35/h3-11,13,17,21H,12,14H2,1-2H3,(H,29,32)(H,28,30,33)/t17?,21-/m1/s1 MNBCZNUKDWVZCV-FBLFFUNLSA-N 81698 4-Substituted Pyrrolidine Ring, 35 Coagulation factor X Homo sapiens 1.0 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81698&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 54592300 131342272 ZINC70463382 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154811 CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)[C@H]2CC(O)CN2C(=O)Nc2ccc(F)cc2)c(F)c1 InChI=1S/C25H23F2N3O5S/c1-36(34,35)23-5-3-2-4-19(23)15-6-11-21(20(27)12-15)29-24(32)22-13-18(31)14-30(22)25(33)28-17-9-7-16(26)8-10-17/h2-12,18,22,31H,13-14H2,1H3,(H,28,33)(H,29,32)/t18?,22-/m1/s1 PDEJQZAMNJMRAN-LMNIDFBRSA-N 81699 4-Substituted Pyrrolidine Ring, 36 Coagulation factor X Homo sapiens 7.6 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81699&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 54592301 131342273 ZINC70463384 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 154801 NS(=O)(=O)c1ccccc1-c1ccc(NC(=O)[C@H]2CC(O)CN2C(=O)Nc2ccc(Cl)cc2)c(F)c1 InChI=1S/C24H22ClFN4O5S/c25-15-6-8-16(9-7-15)28-24(33)30-13-17(31)12-21(30)23(32)29-20-10-5-14(11-19(20)26)18-3-1-2-4-22(18)36(27,34)35/h1-11,17,21,31H,12-13H2,(H,28,33)(H,29,32)(H2,27,34,35)/t17?,21-/m1/s1 FOTQXLYFKKVZMB-FBLFFUNLSA-N 81692 4-Substituted Pyrrolidine Ring, 14 Coagulation factor X Homo sapiens 0.75 Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00520.x 10.7270/Q2PZ5799 17581239 aid1799571 Van Huis, CA; Bigge, CF; Casimiro-Garcia, A; Cody, WL; Dudley, DA; Filipski, KJ; Heemstra, RJ; Kohrt, JT; Narasimhan, LS; Schaum, RP; Zhang, E; Bryant, JW; Haarer, S; Janiczek, N; Leadley, RJ; McClanahan, T; Thomas Peterson, J; Welch, KM; Edmunds, JJ Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81692&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 54592297 131342266 ZINC70463374 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 214272 Cc1cc(ccc1-n1cccc(CO)c1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C22H20ClN3O5S/c1-13-9-15(4-5-17(13)25-8-2-3-14(12-27)21(25)29)26-11-16(31-22(26)30)10-24-20(28)18-6-7-19(23)32-18/h2-9,16,27H,10-12H2,1H3,(H,24,28)/t16-/m0/s1 QGFDDMPEQGUIST-INIZCTEOSA-N 98166 US8487111, 2 Coagulation factor X Homo sapiens 21 US Patent 10.7270/Q29K48V9 aid1799966 US8487111 Allerheiligen, S; Bauser, M; Schirok, H; Rester, U; Heitmeier, S; Gerdes, C; Von Degenfeld, G; Dittrich-Wengenroth, E; Saatmann, U; Straßburger, J; Strasburger, K; Munter, MJ; Lang, D Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=98166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=98166&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 25143687 164039410 ZINC43202332 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 214273 Cc1cc(ccc1-n1cccc(CCO)c1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C23H22ClN3O5S/c1-14-11-16(4-5-18(14)26-9-2-3-15(8-10-28)22(26)30)27-13-17(32-23(27)31)12-25-21(29)19-6-7-20(24)33-19/h2-7,9,11,17,28H,8,10,12-13H2,1H3,(H,25,29)/t17-/m0/s1 WUCJQADZOHCKCX-KRWDZBQOSA-N 98167 US8487111, 6 Coagulation factor X Homo sapiens 70 US Patent 10.7270/Q29K48V9 aid1799966 US8487111 Allerheiligen, S; Bauser, M; Schirok, H; Rester, U; Heitmeier, S; Gerdes, C; Von Degenfeld, G; Dittrich-Wengenroth, E; Saatmann, U; Straßburger, J; Strasburger, K; Munter, MJ; Lang, D Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=98167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=98167&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 25143832 164039411 ZINC43202331 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 214274 COCc1cc(ccc1-n1cccc(CCO)c1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C24H24ClN3O6S/c1-33-14-16-11-17(4-5-19(16)27-9-2-3-15(8-10-29)23(27)31)28-13-18(34-24(28)32)12-26-22(30)20-6-7-21(25)35-20/h2-7,9,11,18,29H,8,10,12-14H2,1H3,(H,26,30)/t18-/m0/s1 VKYVGNOZMWMZDF-SFHVURJKSA-N 98168 US8487111, 8 Coagulation factor X Homo sapiens 167 US Patent 10.7270/Q29K48V9 aid1799966 US8487111 Allerheiligen, S; Bauser, M; Schirok, H; Rester, U; Heitmeier, S; Gerdes, C; Von Degenfeld, G; Dittrich-Wengenroth, E; Saatmann, U; Straßburger, J; Strasburger, K; Munter, MJ; Lang, D Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=98168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=98168&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 25143834 164039412 ZINC43202330 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 214275 Cc1cc(ccc1-n1cccc(CCCO)c1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C24H24ClN3O5S/c1-15-12-17(6-7-19(15)27-10-2-4-16(23(27)31)5-3-11-29)28-14-18(33-24(28)32)13-26-22(30)20-8-9-21(25)34-20/h2,4,6-10,12,18,29H,3,5,11,13-14H2,1H3,(H,26,30)/t18-/m0/s1 WLUQFTQBDKCCLW-SFHVURJKSA-N 98169 US8487111, 10 Coagulation factor X Homo sapiens 40 US Patent 10.7270/Q29K48V9 aid1799966 US8487111 Allerheiligen, S; Bauser, M; Schirok, H; Rester, U; Heitmeier, S; Gerdes, C; Von Degenfeld, G; Dittrich-Wengenroth, E; Saatmann, U; Straßburger, J; Strasburger, K; Munter, MJ; Lang, D Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=98169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=98169&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 25108832 164039413 ZINC43202333 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228219 NC(=N)c1ccc(CNC(=O)[C@H](CCC2CCNCC2)NC(=O)[C@@H](CCCn2cnnn2)NS(=O)(=O)Cc2ccccc2)cc1 InChI=1S/C30H42N10O4S/c31-28(32)25-11-8-23(9-12-25)19-34-29(41)26(13-10-22-14-16-33-17-15-22)36-30(42)27(7-4-18-40-21-35-38-39-40)37-45(43,44)20-24-5-2-1-3-6-24/h1-3,5-6,8-9,11-12,21-22,26-27,33,37H,4,7,10,13-20H2,(H3,31,32)(H,34,41)(H,36,42)/t26-,27+/m0/s1 RUUQARAMINJWGP-RRPNLBNLSA-N 108118 US8598206, Table 6, 1 Coagulation factor X Homo sapiens 2400 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108118&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345654 186524988 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228220 NC(=N)c1ccc(CNC(=O)[C@H](CCC2CCNCC2)NC(=O)[C@@H](CCCc2ccncc2)NS(=O)(=O)Cc2ccccc2)cc1 InChI=1S/C34H45N7O4S/c35-32(36)29-12-9-27(10-13-29)23-39-33(42)30(14-11-26-17-21-38-22-18-26)40-34(43)31(8-4-7-25-15-19-37-20-16-25)41-46(44,45)24-28-5-2-1-3-6-28/h1-3,5-6,9-10,12-13,15-16,19-20,26,30-31,38,41H,4,7-8,11,14,17-18,21-24H2,(H3,35,36)(H,39,42)(H,40,43)/t30-,31+/m0/s1 VNKFZBCCJJVXJG-IOWSJCHKSA-N 108117 US8598206, Table 6, 2 Coagulation factor X Homo sapiens 850 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108117&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345653 186524987 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228221 COC(=O)c1cccc(CS(=O)(=O)N[C@H](CCCc2ccccc2)C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCc2ccc(cc2)C(N)=N)c1 InChI=1S/C37H48N6O6S/c1-49-37(46)31-11-5-10-29(23-31)25-50(47,48)43-33(12-6-9-26-7-3-2-4-8-26)36(45)42-32(18-15-27-19-21-40-22-20-27)35(44)41-24-28-13-16-30(17-14-28)34(38)39/h2-5,7-8,10-11,13-14,16-17,23,27,32-33,40,43H,6,9,12,15,18-22,24-25H2,1H3,(H3,38,39)(H,41,44)(H,42,45)/t32-,33+/m0/s1 JPGNXUNXIAMWMQ-JHOUSYSJSA-N 108116 US8598206, Table 6, 3 Coagulation factor X Homo sapiens 5900 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108116&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345754 186524986 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228222 NC(=N)c1ccc(CNC(=O)[C@H](CCC2CCNCC2)NC(=O)[C@@H](CCCc2ccccc2)NS(=O)(=O)Cc2cccc(c2)C(O)=O)cc1 InChI=1S/C36H46N6O6S/c37-33(38)29-15-12-27(13-16-29)23-40-34(43)31(17-14-26-18-20-39-21-19-26)41-35(44)32(11-5-8-25-6-2-1-3-7-25)42-49(47,48)24-28-9-4-10-30(22-28)36(45)46/h1-4,6-7,9-10,12-13,15-16,22,26,31-32,39,42H,5,8,11,14,17-21,23-24H2,(H3,37,38)(H,40,43)(H,41,44)(H,45,46)/t31-,32+/m0/s1 OITRKHUOZGPBJI-AJQTZOPKSA-N 108095 US8598206, Table 6, 4 Coagulation factor X Homo sapiens 2400 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108095&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345755 186524965 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228223 CC(=O)N1CCC(CC[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCc2ccc(cc2)C(N)=N)CC1 InChI=1S/C35H51N7O5S/c1-25(43)42-21-17-27(18-22-42)10-14-32(41-48(46,47)24-29-5-3-2-4-6-29)35(45)40-31(13-9-26-15-19-38-20-16-26)34(44)39-23-28-7-11-30(12-8-28)33(36)37/h2-8,11-12,26-27,31-32,38,41H,9-10,13-24H2,1H3,(H3,36,37)(H,39,44)(H,40,45)/t31-,32+/m0/s1 XATHBXYKVIAZOR-AJQTZOPKSA-N 108096 US8598206, Table 6, 5 Coagulation factor X Homo sapiens 1900 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108096&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345860 186524966 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228224 NC(=N)c1ccc(CNC(=O)[C@H](CCC2CCNCC2)NC(=O)[C@@H](CCCC2CCNCC2)NS(=O)(=O)Cc2ccccc2)cc1 InChI=1S/C34H51N7O4S/c35-32(36)29-12-9-27(10-13-29)23-39-33(42)30(14-11-26-17-21-38-22-18-26)40-34(43)31(8-4-7-25-15-19-37-20-16-25)41-46(44,45)24-28-5-2-1-3-6-28/h1-3,5-6,9-10,12-13,25-26,30-31,37-38,41H,4,7-8,11,14-24H2,(H3,35,36)(H,39,42)(H,40,43)/t30-,31+/m0/s1 FDLUVBKZNIPEQR-IOWSJCHKSA-N 108097 US8598206, Table 6, 6 Coagulation factor X Homo sapiens 300 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108097&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53346079 186524967 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228225 NC(=N)c1ccc(CNC(=O)[C@H](CCC2CCNCC2)NC(=O)[C@@H](CCC2CCN(CC2)C(=O)C2CC2)NS(=O)(=O)Cc2ccccc2)cc1 InChI=1S/C37H53N7O5S/c38-34(39)30-10-6-28(7-11-30)24-41-35(45)32(14-8-26-16-20-40-21-17-26)42-36(46)33(43-50(48,49)25-29-4-2-1-3-5-29)15-9-27-18-22-44(23-19-27)37(47)31-12-13-31/h1-7,10-11,26-27,31-33,40,43H,8-9,12-25H2,(H3,38,39)(H,41,45)(H,42,46)/t32-,33+/m0/s1 DIFGLRSYVDIDJS-JHOUSYSJSA-N 108098 US8598206, Table 6, 7 Coagulation factor X Homo sapiens 2300 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108098&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345968 186524968 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228226 CCC(=O)N1CCC(CC[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCc2ccc(cc2)C(N)=N)CC1 InChI=1S/C36H53N7O5S/c1-2-33(44)43-22-18-27(19-23-43)11-15-32(42-49(47,48)25-29-6-4-3-5-7-29)36(46)41-31(14-10-26-16-20-39-21-17-26)35(45)40-24-28-8-12-30(13-9-28)34(37)38/h3-9,12-13,26-27,31-32,39,42H,2,10-11,14-25H2,1H3,(H3,37,38)(H,40,45)(H,41,46)/t31-,32+/m0/s1 LWFLIRIWEPBXFX-AJQTZOPKSA-N 108099 US8598206, Table 6, 8 Coagulation factor X Homo sapiens 2300 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108099&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53346082 186524969 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228227 CC(=O)N1CCC(CCC[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCc2ccc(cc2)C(N)=N)CC1 InChI=1S/C36H53N7O5S/c1-26(44)43-22-18-27(19-23-43)8-5-9-33(42-49(47,48)25-30-6-3-2-4-7-30)36(46)41-32(15-12-28-16-20-39-21-17-28)35(45)40-24-29-10-13-31(14-11-29)34(37)38/h2-4,6-7,10-11,13-14,27-28,32-33,39,42H,5,8-9,12,15-25H2,1H3,(H3,37,38)(H,40,45)(H,41,46)/t32-,33+/m0/s1 QCJKXYYLKAMQSD-JHOUSYSJSA-N 47177 BDBM108100::US8598206, Table 6, 9 Coagulation factor X Homo sapiens 750 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47177&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53346080 313362578 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228228 NC(=N)c1ccc(CNC(=O)[C@H](CCC2CCNCC2)NC(=O)[C@@H](CCC2CCNCC2)NS(=O)(=O)Cc2ccccc2)cc1 InChI=1S/C33H49N7O4S/c34-31(35)28-10-6-26(7-11-28)22-38-32(41)29(12-8-24-14-18-36-19-15-24)39-33(42)30(13-9-25-16-20-37-21-17-25)40-45(43,44)23-27-4-2-1-3-5-27/h1-7,10-11,24-25,29-30,36-37,40H,8-9,12-23H2,(H3,34,35)(H,38,41)(H,39,42)/t29-,30+/m0/s1 ZTJVQQCXGUIYTL-XZWHSSHBSA-N 108101 US8598206, Table 6, 10 Coagulation factor X Homo sapiens 90 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108101&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53346181 186524971 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228229 COCC(=O)N1CCC(CC[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCc2ccc(cc2)C(N)=N)CC1 InChI=1S/C36H53N7O6S/c1-49-24-33(44)43-21-17-27(18-22-43)10-14-32(42-50(47,48)25-29-5-3-2-4-6-29)36(46)41-31(13-9-26-15-19-39-20-16-26)35(45)40-23-28-7-11-30(12-8-28)34(37)38/h2-8,11-12,26-27,31-32,39,42H,9-10,13-25H2,1H3,(H3,37,38)(H,40,45)(H,41,46)/t31-,32+/m0/s1 DTIUMOLBWQXRPH-AJQTZOPKSA-N 108102 US8598206, Table 6, 11 Coagulation factor X Homo sapiens 1600 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108102&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345862 186524972 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228230 NC(=N)c1ccc(CNC(=O)[C@H](CCC2CCNCC2)NC(=O)[C@@H](CCc2ccncc2)NS(=O)(=O)Cc2ccccc2)cc1 InChI=1S/C33H43N7O4S/c34-31(35)28-10-6-26(7-11-28)22-38-32(41)29(12-8-24-14-18-36-19-15-24)39-33(42)30(13-9-25-16-20-37-21-17-25)40-45(43,44)23-27-4-2-1-3-5-27/h1-7,10-11,16-17,20-21,24,29-30,36,40H,8-9,12-15,18-19,22-23H2,(H3,34,35)(H,38,41)(H,39,42)/t29-,30+/m0/s1 ZYKYKDNQGMXJQR-XZWHSSHBSA-N 47178 BDBM108103::US8598206, Table 6, 12 Coagulation factor X Homo sapiens 20 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47178&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345752 313362579 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228231 CN(C)C(=O)N1CCC(CC[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCc2ccc(cc2)C(N)=N)CC1 InChI=1S/C36H54N8O5S/c1-43(2)36(47)44-22-18-27(19-23-44)11-15-32(42-50(48,49)25-29-6-4-3-5-7-29)35(46)41-31(14-10-26-16-20-39-21-17-26)34(45)40-24-28-8-12-30(13-9-28)33(37)38/h3-9,12-13,26-27,31-32,39,42H,10-11,14-25H2,1-2H3,(H3,37,38)(H,40,45)(H,41,46)/t31-,32+/m0/s1 WYOJURVOHOBMRY-AJQTZOPKSA-N 108104 US8598206, Table 6, 13 Coagulation factor X Homo sapiens 2500 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108104&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345967 186524974 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228232 CNC(=O)N1CCC(CC[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCc2ccc(cc2)C(N)=N)CC1 InChI=1S/C35H52N8O5S/c1-38-35(46)43-21-17-26(18-22-43)10-14-31(42-49(47,48)24-28-5-3-2-4-6-28)34(45)41-30(13-9-25-15-19-39-20-16-25)33(44)40-23-27-7-11-29(12-8-27)32(36)37/h2-8,11-12,25-26,30-31,39,42H,9-10,13-24H2,1H3,(H3,36,37)(H,38,46)(H,40,44)(H,41,45)/t30-,31+/m0/s1 OGCGKERBEQPTBU-IOWSJCHKSA-N 108105 US8598206, Table 6, 14 Coagulation factor X Homo sapiens 1700 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108105&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345863 186524975 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228233 CCCC(=O)N1CCC(CC[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCc2ccc(cc2)C(N)=N)CC1 InChI=1S/C37H55N7O5S/c1-2-6-34(45)44-23-19-28(20-24-44)12-16-33(43-50(48,49)26-30-7-4-3-5-8-30)37(47)42-32(15-11-27-17-21-40-22-18-27)36(46)41-25-29-9-13-31(14-10-29)35(38)39/h3-5,7-10,13-14,27-28,32-33,40,43H,2,6,11-12,15-26H2,1H3,(H3,38,39)(H,41,46)(H,42,47)/t32-,33+/m0/s1 GWZGMZVWURNLOZ-JHOUSYSJSA-N 108106 US8598206, Table 6, 15 Coagulation factor X Homo sapiens 2200 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108106&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345969 186524976 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228234 COC(=O)N1CCC(CC[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCc2ccc(cc2)C(N)=N)CC1 InChI=1S/C35H51N7O6S/c1-48-35(45)42-21-17-26(18-22-42)10-14-31(41-49(46,47)24-28-5-3-2-4-6-28)34(44)40-30(13-9-25-15-19-38-20-16-25)33(43)39-23-27-7-11-29(12-8-27)32(36)37/h2-8,11-12,25-26,30-31,38,41H,9-10,13-24H2,1H3,(H3,36,37)(H,39,43)(H,40,44)/t30-,31+/m0/s1 ZTXALZIIFRKUGE-IOWSJCHKSA-N 108107 US8598206, Table 6, 16 Coagulation factor X Homo sapiens 2000 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108107&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345861 186524977 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228235 NC(=N)c1ccc(CNC(=O)[C@H](CCC2CCNCC2)NC(=O)[C@@H](CCCC2=CC=[N](O)C=C2)NS(=O)(=O)Cc2ccccc2)cc1 InChI=1S/C34H46N7O5S/c35-32(36)29-12-9-27(10-13-29)23-38-33(42)30(14-11-26-15-19-37-20-16-26)39-34(43)31(8-4-7-25-17-21-41(44)22-18-25)40-47(45,46)24-28-5-2-1-3-6-28/h1-3,5-6,9-10,12-13,17-18,21-22,26,30-31,37,40,44H,4,7-8,11,14-16,19-20,23-24H2,(H3,35,36)(H,38,42)(H,39,43)/t30-,31+/m0/s1 LBBUQPWJBKYVNI-IOWSJCHKSA-N 108108 US8598206, 117::US8598206, 123 Coagulation factor X Homo sapiens 400 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108108&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91663788 186524978 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228236 CC(C)C(=O)N1CCC(CC[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCc2ccc(cc2)C(N)=N)CC1 InChI=1S/C37H55N7O5S/c1-26(2)37(47)44-22-18-28(19-23-44)11-15-33(43-50(48,49)25-30-6-4-3-5-7-30)36(46)42-32(14-10-27-16-20-40-21-17-27)35(45)41-24-29-8-12-31(13-9-29)34(38)39/h3-9,12-13,26-28,32-33,40,43H,10-11,14-25H2,1-2H3,(H3,38,39)(H,41,45)(H,42,46)/t32-,33+/m0/s1 RRYHCECMCWJEIU-JHOUSYSJSA-N 108109 US8598206, 118::US8598206, 122 Coagulation factor X Homo sapiens 3200 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108109&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345970 186524979 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228237 NC(=N)c1ccc(CNC(=O)[C@H](CCC2CCNCC2)NC(=O)[C@@H](CCCc2ccccc2)NS(=O)(=O)Cc2ccccc2)cc1 InChI=1S/C35H46N6O4S/c36-33(37)30-17-14-28(15-18-30)24-39-34(42)31(19-16-27-20-22-38-23-21-27)40-35(43)32(13-7-12-26-8-3-1-4-9-26)41-46(44,45)25-29-10-5-2-6-11-29/h1-6,8-11,14-15,17-18,27,31-32,38,41H,7,12-13,16,19-25H2,(H3,36,37)(H,39,42)(H,40,43)/t31-,32+/m0/s1 MCDKKKIUEGNSPK-AJQTZOPKSA-N 108110 US8598206, Table 6, 19 Coagulation factor X Homo sapiens 1100 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108110&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345652 186524980 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228238 NC(=N)c1ccc(CNC(=O)[C@H](CCC2CCNCC2)NC(=O)[C@H](NS(=O)(=O)Cc2ccccc2)c2ccccc2)cc1 InChI=1S/C32H40N6O4S/c33-30(34)27-14-11-24(12-15-27)21-36-31(39)28(16-13-23-17-19-35-20-18-23)37-32(40)29(26-9-5-2-6-10-26)38-43(41,42)22-25-7-3-1-4-8-25/h1-12,14-15,23,28-29,35,38H,13,16-22H2,(H3,33,34)(H,36,39)(H,37,40)/t28-,29+/m0/s1 BQJXMSPBOZFQJJ-URLMMPGGSA-N 108111 US8598206, Table 6, 20 Coagulation factor X Homo sapiens 1600 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108111&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345655 186524981 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228239 NC(=N)c1ccc(CNC(=O)[C@H](CCC2CCNCC2)NC(=O)[C@@H](CCC2=CC=[N](O)C=C2)NS(=O)(=O)Cc2ccccc2)cc1 InChI=1S/C33H44N7O5S/c34-31(35)28-10-6-26(7-11-28)22-37-32(41)29(12-8-24-14-18-36-19-15-24)38-33(42)30(13-9-25-16-20-40(43)21-17-25)39-46(44,45)23-27-4-2-1-3-5-27/h1-7,10-11,16-17,20-21,24,29-30,36,39,43H,8-9,12-15,18-19,22-23H2,(H3,34,35)(H,37,41)(H,38,42)/t29-,30+/m0/s1 CKZGCUFXVIRNEZ-XZWHSSHBSA-N 108112 US8598206, Table 6, 21 Coagulation factor X Homo sapiens 120 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108112&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91663789 186524982 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228240 CC(C)C(=O)N1CCC(CC[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCc2ccc(cc2)C(N)=N)CC1 InChI=1S/C37H55N7O5S/c1-26(2)37(47)44-22-18-28(19-23-44)11-15-33(43-50(48,49)25-30-6-4-3-5-7-30)36(46)42-32(14-10-27-16-20-40-21-17-27)35(45)41-24-29-8-12-31(13-9-29)34(38)39/h3-9,12-13,26-28,32-33,40,43H,10-11,14-25H2,1-2H3,(H3,38,39)(H,41,45)(H,42,46)/t32-,33+/m0/s1 RRYHCECMCWJEIU-JHOUSYSJSA-N 108109 US8598206, 118::US8598206, 122 Coagulation factor X Homo sapiens 3200 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108109&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53345970 186524979 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228241 NC(=N)c1ccc(CNC(=O)[C@H](CCC2CCNCC2)NC(=O)[C@@H](CCCC2=CC=[N](O)C=C2)NS(=O)(=O)Cc2ccccc2)cc1 InChI=1S/C34H46N7O5S/c35-32(36)29-12-9-27(10-13-29)23-38-33(42)30(14-11-26-15-19-37-20-16-26)39-34(43)31(8-4-7-25-17-21-41(44)22-18-25)40-47(45,46)24-28-5-2-1-3-6-28/h1-3,5-6,9-10,12-13,17-18,21-22,26,30-31,37,40,44H,4,7-8,11,14-16,19-20,23-24H2,(H3,35,36)(H,38,42)(H,39,43)/t30-,31+/m0/s1 LBBUQPWJBKYVNI-IOWSJCHKSA-N 108108 US8598206, 117::US8598206, 123 Coagulation factor X Homo sapiens 400 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108108&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 91663788 186524978 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 228242 COC(=O)N1CCC(CCC[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)N[C@@H](CCC2CCNCC2)C(=O)NCc2ccc(cc2)C(N)=N)CC1 InChI=1S/C36H53N7O6S/c1-49-36(46)43-22-18-26(19-23-43)8-5-9-32(42-50(47,48)25-29-6-3-2-4-7-29)35(45)41-31(15-12-27-16-20-39-21-17-27)34(44)40-24-28-10-13-30(14-11-28)33(37)38/h2-4,6-7,10-11,13-14,26-27,31-32,39,42H,5,8-9,12,15-25H2,1H3,(H3,37,38)(H,40,44)(H,41,45)/t31-,32+/m0/s1 BJSIWIFJSRFHPS-AJQTZOPKSA-N 108115 US8598206, Table 6, 24 Coagulation factor X Homo sapiens 400 US Patent 10.7270/Q25T3J5F aid1800209 US8598206 Herold, P; Daghish, M; Jelakovic, S; Ludwig, F; Reichelt, C; Schulze, A; Schweinitz, A The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108115&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 53346081 186524985 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262387 OCC(=O)N1CCN(CC1)c1ccc(cc1F)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C21H22ClFN4O5S/c22-18-4-3-17(33-18)20(30)24-10-14-11-27(21(31)32-14)13-1-2-16(15(23)9-13)25-5-7-26(8-6-25)19(29)12-28/h1-4,9,14,28H,5-8,10-12H2,(H,24,30)/t14-/m0/s1 LSMJWDIHLCYVFL-AWEZNQCLSA-N 130520 US8822458, 48 Coagulation factor X Homo sapiens 120 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130520&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777734 225156854 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262388 CN(C)c1ccc(cc1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C17H18ClN3O3S/c1-20(2)11-3-5-12(6-4-11)21-10-13(24-17(21)23)9-19-16(22)14-7-8-15(18)25-14/h3-8,13H,9-10H2,1-2H3,(H,19,22)/t13-/m0/s1 SDPNOIGDWTUQEV-ZDUSSCGKSA-N 12993 5-Chloro-N-({(5S)-3-[4-(dimethylamino)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide::5-chloro-N-{[(5S)-3-[4-(dimethylamino)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide::BAY 59-7939 Analog 9::US8822458, 49 Coagulation factor X Homo sapiens 74 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12993&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11523750 46513419 ZINC12354881 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262389 CC1Oc2cc(ccc2N(C)C1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C19H18ClN3O5S/c1-10-18(25)22(2)13-4-3-11(7-14(13)27-10)23-9-12(28-19(23)26)8-21-17(24)15-5-6-16(20)29-15/h3-7,10,12H,8-9H2,1-2H3,(H,21,24)/t10?,12-/m0/s1 KJHJENBNBAVKDZ-KFJBMODSSA-N 130521 US8822458, 50 Coagulation factor X Homo sapiens 1150 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130521&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777751 225156855 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262390 CN1C(=O)COc2cc(ccc12)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C18H16ClN3O5S/c1-21-12-3-2-10(6-13(12)26-9-16(21)23)22-8-11(27-18(22)25)7-20-17(24)14-4-5-15(19)28-14/h2-6,11H,7-9H2,1H3,(H,20,24)/t11-/m0/s1 ZOJJEZDOSBSXLZ-NSHDSACASA-N 130522 US8822458, 51 Coagulation factor X Homo sapiens 1190 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130522&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777694 225156856 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262391 NC1CCN(C1)c1ccc(cn1)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C18H20ClN5O3S/c19-15-3-2-14(28-15)17(25)22-8-13-10-24(18(26)27-13)12-1-4-16(21-7-12)23-6-5-11(20)9-23/h1-4,7,11,13H,5-6,8-10,20H2,(H,22,25)/t11?,13-/m0/s1 VKDLWAZJLCBNGK-YUZLPWPTSA-N 130523 US8822458, 52 Coagulation factor X Homo sapiens 190 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130523&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777757 225156857 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262392 Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc-2c(OCc3nccn-23)c1 InChI=1S/C19H15ClN4O4S/c20-16-4-3-15(29-16)18(25)22-8-12-9-24(19(26)28-12)11-1-2-13-14(7-11)27-10-17-21-5-6-23(13)17/h1-7,12H,8-10H2,(H,22,25)/t12-/m0/s1 IVDILMMHQWFRRE-LBPRGKRZSA-N 130524 US8822458, 53 Coagulation factor X Homo sapiens 740 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130524&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 12042977 225156858 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262393 Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(N2CCCC2)c(c1)C#N InChI=1S/C20H19ClN4O3S/c21-18-6-5-17(29-18)19(26)23-11-15-12-25(20(27)28-15)14-3-4-16(13(9-14)10-22)24-7-1-2-8-24/h3-6,9,15H,1-2,7-8,11-12H2,(H,23,26)/t15-/m0/s1 UEMHJTMVMPPAJL-HNNXBMFYSA-N 130525 US8822458, 54 Coagulation factor X Homo sapiens 130 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130525&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777759 225156859 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262394 Clc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCOC1=O InChI=1S/C18H16ClN3O5S/c19-15-6-5-14(28-15)16(23)20-9-13-10-22(18(25)27-13)12-3-1-11(2-4-12)21-7-8-26-17(21)24/h1-6,13H,7-10H2,(H,20,23)/t13-/m0/s1 JFBDEZAXUXVNID-ZDUSSCGKSA-N 130526 US8822458, 55 Coagulation factor X Homo sapiens 40 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130526&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777717 225156860 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262395 Brc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCCC1=O InChI=1S/C19H18BrN3O4S/c20-16-8-7-15(28-16)18(25)21-10-14-11-23(19(26)27-14)13-5-3-12(4-6-13)22-9-1-2-17(22)24/h3-8,14H,1-2,9-11H2,(H,21,25)/t14-/m0/s1 ODBNMTFTNNWNCT-AWEZNQCLSA-N 130527 US8822458, 56 Coagulation factor X Homo sapiens 4 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130527&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777746 225156861 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262396 Cc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCCC1=O InChI=1S/C20H21N3O4S/c1-13-4-9-17(28-13)19(25)21-11-16-12-23(20(26)27-16)15-7-5-14(6-8-15)22-10-2-3-18(22)24/h4-9,16H,2-3,10-12H2,1H3,(H,21,25)/t16-/m0/s1 JDZMFDDYWDYSSV-INIZCTEOSA-N 130528 US8822458, 57 Coagulation factor X Homo sapiens 580 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130528&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777767 225156862 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262397 NC1CCN(C1)c1ccc(cc1F)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C19H20ClFN4O3S/c20-17-4-3-16(29-17)18(26)23-8-13-10-25(19(27)28-13)12-1-2-15(14(21)7-12)24-6-5-11(22)9-24/h1-4,7,11,13H,5-6,8-10,22H2,(H,23,26) CHWLKSLEUUHXEB-UHFFFAOYSA-N 130529 US8822458, 126 Coagulation factor X Homo sapiens 13 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130529&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777684 225156863 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262398 Fc1cc(ccc1N1CCOCC1=O)N1C[C@H](CNC(=O)c2ccc(Br)s2)OC1=O InChI=1S/C19H17BrFN3O5S/c20-16-4-3-15(30-16)18(26)22-8-12-9-24(19(27)29-12)11-1-2-14(13(21)7-11)23-5-6-28-10-17(23)25/h1-4,7,12H,5-6,8-10H2,(H,22,26)/t12-/m0/s1 AVDMAGXTFXQPIZ-LBPRGKRZSA-N 130530 US8822458, 127 Coagulation factor X Homo sapiens 0.7 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130530&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777754 225156864 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262399 Fc1cc(ccc1N1CCCC1=O)N1C[C@H](CNC(=O)c2ccc(Br)s2)OC1=O InChI=1S/C19H17BrFN3O4S/c20-16-6-5-15(29-16)18(26)22-9-12-10-24(19(27)28-12)11-3-4-14(13(21)8-11)23-7-1-2-17(23)25/h3-6,8,12H,1-2,7,9-10H2,(H,22,26)/t12-/m0/s1 UWNDWLUSUQOFBS-LBPRGKRZSA-N 130531 US8822458, 128 Coagulation factor X Homo sapiens 2 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130531&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777699 225156865 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262400 Brc1ccc(s1)C(=O)NC[C@H]1CN(C(=O)O1)c1ccc(cc1)N1CCCCC1=O InChI=1S/C20H20BrN3O4S/c21-17-9-8-16(29-17)19(26)22-11-15-12-24(20(27)28-15)14-6-4-13(5-7-14)23-10-2-1-3-18(23)25/h4-9,15H,1-3,10-12H2,(H,22,26)/t15-/m0/s1 KBRZZTZXVQVSKY-HNNXBMFYSA-N 130532 US8822458, 129 Coagulation factor X Homo sapiens 1 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130532&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777736 225156866 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262401 Fc1cc(ccc1N1CCCC1=O)N1C[C@H](CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C19H17ClFN3O4S/c20-16-6-5-15(29-16)18(26)22-9-12-10-24(19(27)28-12)11-3-4-14(13(21)8-11)23-7-1-2-17(23)25/h3-6,8,12H,1-2,7,9-10H2,(H,22,26)/t12-/m0/s1 OSYKJAFAQUNRFN-LBPRGKRZSA-N 130533 US8822458, 130 Coagulation factor X Homo sapiens 3.3 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130533&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10160285 225156867 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262402 Clc1ccc(s1)C(=O)NCC1CN(C(=O)O1)c1ccc(cc1)C1CCCCC1 InChI=1S/C21H23ClN2O3S/c22-19-11-10-18(28-19)20(25)23-12-17-13-24(21(26)27-17)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h6-11,14,17H,1-5,12-13H2,(H,23,25) WWOCGHITABMUNN-UHFFFAOYSA-N 130534 US8822458, 131 Coagulation factor X Homo sapiens 850 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130534&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777780 225156868 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262403 Fc1cc(ccc1N1CCC1)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C18H17ClFN3O3S/c19-16-5-4-15(27-16)17(24)21-9-12-10-23(18(25)26-12)11-2-3-14(13(20)8-11)22-6-1-7-22/h2-5,8,12H,1,6-7,9-10H2,(H,21,24) PTKUFCDBZCKBJW-UHFFFAOYSA-N 130535 US8822458, 132 Coagulation factor X Homo sapiens 120 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130535&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777675 225156869 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262404 OC1CCN(C1)c1ccc(cc1F)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C19H19ClFN3O4S/c20-17-4-3-16(29-17)18(26)22-8-13-10-24(19(27)28-13)11-1-2-15(14(21)7-11)23-6-5-12(25)9-23/h1-4,7,12-13,25H,5-6,8-10H2,(H,22,26) HYLFUJWLOLVJRE-UHFFFAOYSA-N 130536 US8822458, 133 Coagulation factor X Homo sapiens 62 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130536&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777738 225156870 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262405 OC1CCCN(C1)c1ccc(cc1F)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C20H21ClFN3O4S/c21-18-6-5-17(30-18)19(27)23-9-14-11-25(20(28)29-14)12-3-4-16(15(22)8-12)24-7-1-2-13(26)10-24/h3-6,8,13-14,26H,1-2,7,9-11H2,(H,23,27) DSPTYTXUFIODET-UHFFFAOYSA-N 130537 US8822458, 134 Coagulation factor X Homo sapiens 480 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130537&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777742 225156871 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262406 CC(C)(C)OC(=O)NC1CCCN(C1)c1ccc(cc1F)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C25H30ClFN4O5S/c1-25(2,3)36-23(33)29-15-5-4-10-30(13-15)19-7-6-16(11-18(19)27)31-14-17(35-24(31)34)12-28-22(32)20-8-9-21(26)37-20/h6-9,11,15,17H,4-5,10,12-14H2,1-3H3,(H,28,32)(H,29,33) WWVSDIXIKBVVML-UHFFFAOYSA-N 130538 US8822458, 135 Coagulation factor X Homo sapiens 1100 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130538&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777692 225156872 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262407 CC1(N)CCN(CC1)c1ccc(cc1F)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C21H24ClFN4O3S/c1-21(24)6-8-26(9-7-21)16-3-2-13(10-15(16)23)27-12-14(30-20(27)29)11-25-19(28)17-4-5-18(22)31-17/h2-5,10,14H,6-9,11-12,24H2,1H3,(H,25,28) IMSZAUYUASXLBS-UHFFFAOYSA-N 130539 US8822458, 136 Coagulation factor X Homo sapiens 1200 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130539&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777730 225156873 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262408 NC1CCCN(C1)c1ccc(cc1F)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C20H22ClFN4O3S/c21-18-6-5-17(30-18)19(27)24-9-14-11-26(20(28)29-14)13-3-4-16(15(22)8-13)25-7-1-2-12(23)10-25/h3-6,8,12,14H,1-2,7,9-11,23H2,(H,24,27) BPEKZRXHJUFHAM-UHFFFAOYSA-N 130540 US8822458, 137 Coagulation factor X Homo sapiens 44 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130540&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777709 225156874 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262409 OCCCNc1ccc(cc1)N1CC(CNC(=O)c2ccc(Cl)s2)OC1=O InChI=1S/C18H20ClN3O4S/c19-16-7-6-15(27-16)17(24)21-10-14-11-22(18(25)26-14)13-4-2-12(3-5-13)20-8-1-9-23/h2-7,14,20,23H,1,8-11H2,(H,21,24) HMOVJANPMNUNDK-UHFFFAOYSA-N 130541 US8822458, 138 Coagulation factor X Homo sapiens 420 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130541&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58777680 225156875 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 262410 Clc1ccc(s1)C(=O)NCC1CN(C(=O)O1)c1ccc(cc1)-n1cccc1 InChI=1S/C19H16ClN3O3S/c20-17-8-7-16(27-17)18(24)21-11-15-12-23(19(25)26-15)14-5-3-13(4-6-14)22-9-1-2-10-22/h1-10,15H,11-12H2,(H,21,24) RRMGVGVYLSXUEY-UHFFFAOYSA-N 130542 US8822458, 139 Coagulation factor X Homo sapiens 1700 25.00 C US Patent 10.7270/Q2VH5MJ2 aid1800646 US8822458 Straub, A; Lampe, T; Pohlmann, J; Rohrig, S; Perzborn, E; Schlemmer, K; Pernerstofer, J Bayer Intellectual Property GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=130542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=130542&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 12041510 225156876 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 273557 CCc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2ccc(nc2)N(C)C)C1=O)C(O)=O InChI=1S/C25H30N6O5S/c1-4-15-12-19-16(7-9-27-23(19)26)11-17(15)13-21(25(33)34)31-10-8-20(24(31)32)29-37(35,36)18-5-6-22(28-14-18)30(2)3/h5-7,9,11-12,14,20-21,29H,4,8,10,13H2,1-3H3,(H2,26,27)(H,33,34)/t20-,21+/m0/s1 DAVMEQIDLFGLFH-LEWJYISDSA-N 60667 BDBM183000::US9150544, 34 Coagulation factor X Homo sapiens 32 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60667&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626032 316921781 ZINC03032817 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 276700 NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cn(Cc4cccc(Cn5cc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)nn5)c4)nn3)cc1 InChI=1S/C33H35N11O4S/c34-31(35)26-11-9-22(10-12-26)16-36-32(45)29-14-27-19-43(41-38-27)17-24-7-4-8-25(13-24)18-44-20-28(39-42-44)15-30(33(46)37-29)40-49(47,48)21-23-5-2-1-3-6-23/h1-13,19-20,29-30,40H,14-18,21H2,(H3,34,35)(H,36,45)(H,37,46)/t29-,30+/m0/s1 BKSCOHJNKDJECO-XZWHSSHBSA-N 50380617 CHEMBL2016873 Coagulation factor X Homo sapiens 206 8 US Patent 10.7270/Q2RX99S6 aid1800815 US8921319 Steinmetzer, T; Saupe, SM The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50380617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50380617&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 56599309 160859700 CHEMBL2016873 ZINC84596939 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 276701 NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cn(Cc4cccc(Cn5cc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)nn5)n4)nn3)cc1 InChI=1S/C32H34N12O4S/c33-30(34)23-11-9-21(10-12-23)15-35-31(45)28-13-26-18-43(41-38-26)16-24-7-4-8-25(36-24)17-44-19-27(39-42-44)14-29(32(46)37-28)40-49(47,48)20-22-5-2-1-3-6-22/h1-12,18-19,28-29,40H,13-17,20H2,(H3,33,34)(H,35,45)(H,37,46)/t28-,29+/m0/s1 PODBMIDYMFKRKE-URLMMPGGSA-N 50380626 CHEMBL2016874 Coagulation factor X Homo sapiens 1860 8 US Patent 10.7270/Q2RX99S6 aid1800815 US8921319 Steinmetzer, T; Saupe, SM The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50380626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50380626&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 56954952 160859709 CHEMBL2016874 ZINC84596940 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 276702 NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(CNC(=O)Cc4cccc(CC(=O)NCc5ccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)cc5)c4)cc3)cc1 InChI=1S/C45H47N7O6S/c46-43(47)38-19-17-34(18-20-38)28-50-44(55)39-22-30-9-13-32(14-10-30)26-48-41(53)24-36-7-4-8-37(21-36)25-42(54)49-27-33-15-11-31(12-16-33)23-40(45(56)51-39)52-59(57,58)29-35-5-2-1-3-6-35/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1 VQUIFQIXWHRTLG-IOLBBIBUSA-N 141387 US8921319, 3 Coagulation factor X Homo sapiens 5700 8 US Patent 10.7270/Q2RX99S6 aid1800815 US8921319 Steinmetzer, T; Saupe, SM The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=141387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=141387&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 89843663 251855665 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 276703 NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(CNC(=O)Cc4ccc(CC(=O)NCc5ccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)cc5)cc4)cc3)cc1 InChI=1S/C45H47N7O6S/c46-43(47)38-20-18-36(19-21-38)28-50-44(55)39-22-30-10-14-34(15-11-30)26-48-41(53)24-32-6-8-33(9-7-32)25-42(54)49-27-35-16-12-31(13-17-35)23-40(45(56)51-39)52-59(57,58)29-37-4-2-1-3-5-37/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1 XNDGXBNDCNRYDE-IOLBBIBUSA-N 50380621 CHEMBL2016864 Coagulation factor X Homo sapiens 9370 8 US Patent 10.7270/Q2RX99S6 aid1800815 US8921319 Steinmetzer, T; Saupe, SM The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50380621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50380621&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 56954732 160859704 CHEMBL2016864 ZINC95550988 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 276704 NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)Cc4cccc(CC(=O)NCc5cccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)c5)c4)c3)cc1 InChI=1S/C45H47N7O6S/c46-43(47)38-17-15-30(16-18-38)26-50-44(55)39-22-32-9-5-13-36(20-32)27-48-41(53)24-34-11-4-12-35(19-34)25-42(54)49-28-37-14-6-10-33(21-37)23-40(45(56)51-39)52-59(57,58)29-31-7-2-1-3-8-31/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1 MLVTZWQEWUGCSC-IOLBBIBUSA-N 50380623 CHEMBL2016870 Coagulation factor X Homo sapiens 42.1 8 US Patent 10.7270/Q2RX99S6 aid1800815 US8921319 Steinmetzer, T; Saupe, SM The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50380623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50380623&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 56954834 160859706 CHEMBL2016870 ZINC95550895 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 276705 NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)Cc4ccc(CC(=O)NCc5cccc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)c5)cc4)c3)cc1 InChI=1S/C45H47N7O6S/c46-43(47)38-18-16-32(17-19-38)26-50-44(55)39-22-34-8-4-10-36(20-34)27-48-41(53)24-30-12-14-31(15-13-30)25-42(54)49-28-37-11-5-9-35(21-37)23-40(45(56)51-39)52-59(57,58)29-33-6-2-1-3-7-33/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1 UIBUHBYTPNMHCK-IOLBBIBUSA-N 50380618 CHEMBL2016868 Coagulation factor X Homo sapiens 152 8 US Patent 10.7270/Q2RX99S6 aid1800815 US8921319 Steinmetzer, T; Saupe, SM The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50380618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50380618&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 56640092 160859701 CHEMBL2016868 ZINC95550857 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 276706 NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)Cc4ccccc4CC(=O)NCc4cccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)c4)c3)cc1 InChI=1S/C45H47N7O6S/c46-43(47)36-18-16-30(17-19-36)26-50-44(55)39-22-32-10-6-12-34(20-32)27-48-41(53)24-37-14-4-5-15-38(37)25-42(54)49-28-35-13-7-11-33(21-35)23-40(45(56)51-39)52-59(57,58)29-31-8-2-1-3-9-31/h1-21,39-40,52H,22-29H2,(H3,46,47)(H,48,53)(H,49,54)(H,50,55)(H,51,56)/t39-,40+/m0/s1 ZLYCPBBJASZKFG-IOLBBIBUSA-N 141388 US8921319, 7 Coagulation factor X Homo sapiens 103 8 US Patent 10.7270/Q2RX99S6 aid1800815 US8921319 Steinmetzer, T; Saupe, SM The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=141388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=141388&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 89843744 251855666 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 276707 NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cccc(CNC(=O)CN4CCN(CC4)CC(=O)NCc4cccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)c4)c3)cc1 InChI=1S/C43H51N9O6S/c44-41(45)36-14-12-30(13-15-36)24-48-42(55)37-22-32-8-4-10-34(20-32)25-46-39(53)27-51-16-18-52(19-17-51)28-40(54)47-26-35-11-5-9-33(21-35)23-38(43(56)49-37)50-59(57,58)29-31-6-2-1-3-7-31/h1-15,20-21,37-38,50H,16-19,22-29H2,(H3,44,45)(H,46,53)(H,47,54)(H,48,55)(H,49,56)/t37-,38+/m0/s1 UPFBONOEYAFXQG-QPPIDDCLSA-N 50380616 CHEMBL2016869 Coagulation factor X Homo sapiens 26.3 8 US Patent 10.7270/Q2RX99S6 aid1800815 US8921319 Steinmetzer, T; Saupe, SM The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50380616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50380616&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 56640160 160859699 CHEMBL2016869 ZINC95550858 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 276708 NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(CNC(=O)CN4CCN(CC4)CC(=O)NCc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1 InChI=1S/C43H51N9O6S/c44-41(45)36-16-14-34(15-17-36)26-48-42(55)37-22-30-6-10-32(11-7-30)24-46-39(53)27-51-18-20-52(21-19-51)28-40(54)47-25-33-12-8-31(9-13-33)23-38(43(56)49-37)50-59(57,58)29-35-4-2-1-3-5-35/h1-17,37-38,50H,18-29H2,(H3,44,45)(H,46,53)(H,47,54)(H,48,55)(H,49,56)/t37-,38+/m0/s1 IHGDLTOMAAIKHD-QPPIDDCLSA-N 50380622 CHEMBL2016867 Coagulation factor X Homo sapiens 3472 8 US Patent 10.7270/Q2RX99S6 aid1800815 US8921319 Steinmetzer, T; Saupe, SM The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50380622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50380622&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 56954733 160859705 CHEMBL2016867 ZINC95550902 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 276709 NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(OC\C=C/COc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1 InChI=1S/C37H39N5O6S/c38-35(39)30-14-8-28(9-15-30)24-40-36(43)33-22-26-10-16-31(17-11-26)47-20-4-5-21-48-32-18-12-27(13-19-32)23-34(37(44)41-33)42-49(45,46)25-29-6-2-1-3-7-29/h1-19,33-34,42H,20-25H2,(H3,38,39)(H,40,43)(H,41,44)/b5-4-/t33-,34+/m0/s1 XWJGZMVWOIPRDB-CLIZBVFSSA-N 141389 US8921319, 10 Coagulation factor X Homo sapiens 220 8 US Patent 10.7270/Q2RX99S6 aid1800815 US8921319 Steinmetzer, T; Saupe, SM The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=141389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=141389&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 56954835 251855667 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 276710 NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(OCCCCOc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1 InChI=1S/C37H41N5O6S/c38-35(39)30-14-8-28(9-15-30)24-40-36(43)33-22-26-10-16-31(17-11-26)47-20-4-5-21-48-32-18-12-27(13-19-32)23-34(37(44)41-33)42-49(45,46)25-29-6-2-1-3-7-29/h1-3,6-19,33-34,42H,4-5,20-25H2,(H3,38,39)(H,40,43)(H,41,44)/t33-,34+/m0/s1 HFYJVMKRIIAVFV-SZAHLOSFSA-N 50380625 CHEMBL2016872 Coagulation factor X Homo sapiens 2011 8 US Patent 10.7270/Q2RX99S6 aid1800815 US8921319 Steinmetzer, T; Saupe, SM The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50380625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50380625&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 56640226 160859708 CHEMBL2016872 ZINC84596938 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 276711 NC(=N)c1ccc(CNC(=O)[C@@H]2CCCCNC(=O)c3cccc(c3)C(=O)NCCCC[C@@H](NS(=O)(=O)Cc3ccccc3)C(=O)N2)cc1 InChI=1S/C35H43N7O6S/c36-31(37)26-17-15-24(16-18-26)22-40-34(45)29-13-4-6-19-38-32(43)27-11-8-12-28(21-27)33(44)39-20-7-5-14-30(35(46)41-29)42-49(47,48)23-25-9-2-1-3-10-25/h1-3,8-12,15-18,21,29-30,42H,4-7,13-14,19-20,22-23H2,(H3,36,37)(H,38,43)(H,39,44)(H,40,45)(H,41,46)/t29-,30+/m0/s1 FYBDWVPJOGSTDV-XZWHSSHBSA-N 141390 US8921319, 12 Coagulation factor X Homo sapiens 376 8 US Patent 10.7270/Q2RX99S6 aid1800815 US8921319 Steinmetzer, T; Saupe, SM The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=141390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=141390&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 89843696 251855668 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 276712 NC(=N)c1ccc(CNC(=O)[C@@H]2CCC(=O)NCc3cccc(CNC(=O)CC[C@@H](NS(=O)(=O)Cc4ccccc4)C(=O)N2)c3)cc1 InChI=1S/C33H39N7O6S/c34-31(35)26-11-9-22(10-12-26)18-38-32(43)27-13-15-29(41)36-19-24-7-4-8-25(17-24)20-37-30(42)16-14-28(33(44)39-27)40-47(45,46)21-23-5-2-1-3-6-23/h1-12,17,27-28,40H,13-16,18-21H2,(H3,34,35)(H,36,41)(H,37,42)(H,38,43)(H,39,44)/t27-,28+/m0/s1 DBLYNSSCIKMVDW-WUFINQPMSA-N 50380620 CHEMBL2016866 Coagulation factor X Homo sapiens 3430 8 US Patent 10.7270/Q2RX99S6 aid1800815 US8921319 Steinmetzer, T; Saupe, SM The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50380620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50380620&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 56954620 160859703 CHEMBL2016866 ZINC84632384 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 276713 NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3cn(Cc4ccc(Cn5cc(C[C@@H](NS(=O)(=O)Cc6ccccc6)C(=O)N2)nn5)cc4)nn3)cc1 InChI=1S/C33H35N11O4S/c34-31(35)26-12-10-22(11-13-26)16-36-32(45)29-14-27-19-43(41-38-27)17-23-6-8-24(9-7-23)18-44-20-28(39-42-44)15-30(33(46)37-29)40-49(47,48)21-25-4-2-1-3-5-25/h1-13,19-20,29-30,40H,14-18,21H2,(H3,34,35)(H,36,45)(H,37,46)/t29-,30+/m0/s1 YPIIFDXBWMJKHY-XZWHSSHBSA-N 141392 US8921319, 14 Coagulation factor X Homo sapiens 600 8 US Patent 10.7270/Q2RX99S6 aid1800815 US8921319 Steinmetzer, T; Saupe, SM The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=141392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=141392&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 90145679 251855670 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 276714 OC(=O)[C@@H]1Cc2ccc(NC(=O)CN3CCN(CC3)CC(=O)Nc3ccc(C[C@@H](NS(=O)(=O)Cc4ccccc4)C(=O)N1)cc3)cc2 InChI=1S/C33H38N6O7S/c40-30-20-38-14-16-39(17-15-38)21-31(41)35-27-12-8-24(9-13-27)19-29(33(43)44)36-32(42)28(18-23-6-10-26(34-30)11-7-23)37-47(45,46)22-25-4-2-1-3-5-25/h1-13,28-29,37H,14-22H2,(H,34,40)(H,35,41)(H,36,42)(H,43,44)/t28-,29+/m1/s1 MQTMFZBGEJWSRJ-WDYNHAJCSA-N 141391 US8921319, 15 Coagulation factor X Homo sapiens >10000 8 US Patent 10.7270/Q2RX99S6 aid1800815 US8921319 Steinmetzer, T; Saupe, SM The Medicines Company (Leipzig) GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=141391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=141391&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71563253 251855669 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330778 Nc1nccc2c(F)c(C[C@@H](N3CC[C@H](NS(=O)(=O)c4ccc(nc4)N4CCCC4)C3=O)C(O)=O)ccc12 InChI=1S/C25H27FN6O5S/c26-22-15(3-5-18-17(22)7-9-28-23(18)27)13-20(25(34)35)32-12-8-19(24(32)33)30-38(36,37)16-4-6-21(29-14-16)31-10-1-2-11-31/h3-7,9,14,19-20,30H,1-2,8,10-13H2,(H2,27,28)(H,34,35)/t19-,20+/m0/s1 ARZIIAPITGERNS-VQTJNVASSA-N 182967 US9150544, 1 Coagulation factor X Homo sapiens 4680 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182967&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626609 313634379 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330779 COC(=O)[C@@H](Cc1ccc2c(N)nccc2c1F)N1CC[C@H](NS(=O)(=O)c2ccc(nc2)N2CCCC2)C1=O InChI=1S/C26H29FN6O5S/c1-38-26(35)21(14-16-4-6-19-18(23(16)27)8-10-29-24(19)28)33-13-9-20(25(33)34)31-39(36,37)17-5-7-22(30-15-17)32-11-2-3-12-32/h4-8,10,15,20-21,31H,2-3,9,11-14H2,1H3,(H2,28,29)/t20-,21+/m0/s1 HNJFPOPALWJYDN-LEWJYISDSA-N 182968 US9150544, 2 Coagulation factor X Homo sapiens >5000 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182968&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626608 313634380 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330780 CN(C)c1ncc(s1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2ccc3c(N)nccc3c2F)C(O)=O)C1=O InChI=1S/C21H23FN6O5S2/c1-27(2)21-25-10-16(34-21)35(32,33)26-14-6-8-28(19(14)29)15(20(30)31)9-11-3-4-13-12(17(11)22)5-7-24-18(13)23/h3-5,7,10,14-15,26H,6,8-9H2,1-2H3,(H2,23,24)(H,30,31)/t14-,15+/m0/s1 QVGYEGOZKMWZDP-LSDHHAIUSA-N 182972 US9150544, 6 Coagulation factor X Homo sapiens 200 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182972&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626677 313634383 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330781 COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O)C(O)=O InChI=1S/C22H26N6O6S2/c1-27(2)22-25-11-18(35-22)36(32,33)26-15-5-7-28(20(15)29)16(21(30)31)9-13-8-12-4-6-24-19(23)14(12)10-17(13)34-3/h4,6,8,10-11,15-16,26H,5,7,9H2,1-3H3,(H2,23,24)(H,30,31)/t15-,16+/m0/s1 RYAYNCVIJUQFES-JKSUJKDBSA-N 182973 US9150544, 7 Coagulation factor X Homo sapiens 2000 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182973&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626678 313634384 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330782 COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O)C(=O)OCC(C)C InChI=1S/C26H34N6O6S2/c1-15(2)14-38-25(34)20(11-17-10-16-6-8-28-23(27)18(16)12-21(17)37-5)32-9-7-19(24(32)33)30-40(35,36)22-13-29-26(39-22)31(3)4/h6,8,10,12-13,15,19-20,30H,7,9,11,14H2,1-5H3,(H2,27,28)/t19-,20+/m0/s1 DSVIVCYXVBEWMO-VQTJNVASSA-N 182974 US9150544, 8 Coagulation factor X Homo sapiens 100 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182974&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626679 313634385 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330783 COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O)C(=O)OCC1CC1 InChI=1S/C26H32N6O6S2/c1-31(2)26-29-13-22(39-26)40(35,36)30-19-7-9-32(24(19)33)20(25(34)38-14-15-4-5-15)11-17-10-16-6-8-28-23(27)18(16)12-21(17)37-3/h6,8,10,12-13,15,19-20,30H,4-5,7,9,11,14H2,1-3H3,(H2,27,28)/t19-,20+/m0/s1 YHTYOGLMOBEAHD-VQTJNVASSA-N 182975 US9150544, 9 Coagulation factor X Homo sapiens 29 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182975&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626680 313634386 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330784 COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O)C(=O)OCC1CCC1 InChI=1S/C27H34N6O6S2/c1-32(2)27-30-14-23(40-27)41(36,37)31-20-8-10-33(25(20)34)21(26(35)39-15-16-5-4-6-16)12-18-11-17-7-9-29-24(28)19(17)13-22(18)38-3/h7,9,11,13-14,16,20-21,31H,4-6,8,10,12,15H2,1-3H3,(H2,28,29)/t20-,21+/m0/s1 UCZCHLSMAUGBNL-LEWJYISDSA-N 182976 US9150544, 10 Coagulation factor X Homo sapiens 86 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182976&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626681 313634387 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330785 COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O)C(=O)OC(C)C InChI=1S/C25H32N6O6S2/c1-14(2)37-24(33)19(11-16-10-15-6-8-27-22(26)17(15)12-20(16)36-5)31-9-7-18(23(31)32)29-39(34,35)21-13-28-25(38-21)30(3)4/h6,8,10,12-14,18-19,29H,7,9,11H2,1-5H3,(H2,26,27)/t18-,19+/m0/s1 DHIJFHQMFQOZAB-RBUKOAKNSA-N 182977 US9150544, 11 Coagulation factor X Homo sapiens 21 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182977&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626745 313634388 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330786 COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O)C(=O)OC1CCCC1 InChI=1S/C27H34N6O6S2/c1-32(2)27-30-15-23(40-27)41(36,37)31-20-9-11-33(25(20)34)21(26(35)39-18-6-4-5-7-18)13-17-12-16-8-10-29-24(28)19(16)14-22(17)38-3/h8,10,12,14-15,18,20-21,31H,4-7,9,11,13H2,1-3H3,(H2,28,29)/t20-,21+/m0/s1 UDYIKQVGKWZFOI-LEWJYISDSA-N 182978 US9150544, 12 Coagulation factor X Homo sapiens 43 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182978&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626746 313634389 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330787 CCOC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1OC)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O InChI=1S/C24H30N6O6S2/c1-5-36-23(32)18(11-15-10-14-6-8-26-21(25)16(14)12-19(15)35-4)30-9-7-17(22(30)31)28-38(33,34)20-13-27-24(37-20)29(2)3/h6,8,10,12-13,17-18,28H,5,7,9,11H2,1-4H3,(H2,25,26)/t17-,18+/m0/s1 SKBXNVFZPUDRNW-ZWKOTPCHSA-N 182979 US9150544, 13 Coagulation factor X Homo sapiens 21 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182979&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626747 313634390 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330788 COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCCC2)C1=O)C(O)=O InChI=1S/C24H28N6O6S2/c1-36-19-12-16-14(4-6-26-21(16)25)10-15(19)11-18(23(32)33)30-9-5-17(22(30)31)28-38(34,35)20-13-27-24(37-20)29-7-2-3-8-29/h4,6,10,12-13,17-18,28H,2-3,5,7-9,11H2,1H3,(H2,25,26)(H,32,33)/t17-,18+/m0/s1 YKLKZWGBQYRUIA-ZWKOTPCHSA-N 182980 US9150544, 14 Coagulation factor X Homo sapiens 4 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182980&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626748 313634391 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330789 COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCCC2)C1=O)C(=O)OCC1CC1 InChI=1S/C28H34N6O6S2/c1-39-23-14-20-18(6-8-30-25(20)29)12-19(23)13-22(27(36)40-16-17-4-5-17)34-11-7-21(26(34)35)32-42(37,38)24-15-31-28(41-24)33-9-2-3-10-33/h6,8,12,14-15,17,21-22,32H,2-5,7,9-11,13,16H2,1H3,(H2,29,30)/t21-,22+/m0/s1 SZVUPCACLGZLOB-FCHUYYIVSA-N 182981 US9150544, 15 Coagulation factor X Homo sapiens 120 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182981&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626749 313634392 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330790 CCOC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1OC)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCCC2)C1=O InChI=1S/C26H32N6O6S2/c1-3-38-25(34)20(13-17-12-16-6-8-28-23(27)18(16)14-21(17)37-2)32-11-7-19(24(32)33)30-40(35,36)22-15-29-26(39-22)31-9-4-5-10-31/h6,8,12,14-15,19-20,30H,3-5,7,9-11,13H2,1-2H3,(H2,27,28)/t19-,20+/m0/s1 AFQXENPUPUCZSM-VQTJNVASSA-N 182982 US9150544, 16 Coagulation factor X Homo sapiens 74 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182982&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626808 313634393 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330791 COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCC(F)(F)C2)C1=O)C(O)=O InChI=1S/C24H26F2N6O6S2/c1-38-18-10-15-13(2-5-28-20(15)27)8-14(18)9-17(22(34)35)32-6-3-16(21(32)33)30-40(36,37)19-11-29-23(39-19)31-7-4-24(25,26)12-31/h2,5,8,10-11,16-17,30H,3-4,6-7,9,12H2,1H3,(H2,27,28)(H,34,35)/t16-,17+/m0/s1 MASLUDJVSFZZCR-DLBZAZTESA-N 182983 US9150544, 17 Coagulation factor X Homo sapiens 17 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182983&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626809 313634394 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330792 CCOC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1OC)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCC(F)(F)C2)C1=O InChI=1S/C26H30F2N6O6S2/c1-3-40-24(36)19(11-16-10-15-4-7-30-22(29)17(15)12-20(16)39-2)34-8-5-18(23(34)35)32-42(37,38)21-13-31-25(41-21)33-9-6-26(27,28)14-33/h4,7,10,12-13,18-19,32H,3,5-6,8-9,11,14H2,1-2H3,(H2,29,30)/t18-,19+/m0/s1 AVDMRYABNBCYPY-RBUKOAKNSA-N 182984 US9150544, 18 Coagulation factor X Homo sapiens 120 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182984&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626810 313634395 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330793 COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCC(F)(F)C2)C1=O)C(=O)OCC1CC1 InChI=1S/C28H32F2N6O6S2/c1-41-22-12-19-17(4-7-32-24(19)31)10-18(22)11-21(26(38)42-14-16-2-3-16)36-8-5-20(25(36)37)34-44(39,40)23-13-33-27(43-23)35-9-6-28(29,30)15-35/h4,7,10,12-13,16,20-21,34H,2-3,5-6,8-9,11,14-15H2,1H3,(H2,31,32)/t20-,21+/m0/s1 MEJMIZVFTUQQKE-LEWJYISDSA-N 182985 US9150544, 19 Coagulation factor X Homo sapiens 1000 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182985&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626811 313634396 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330794 COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCC(F)(F)C2)C1=O)C(=O)OC(C)C InChI=1S/C27H32F2N6O6S2/c1-15(2)41-25(37)20(11-17-10-16-4-7-31-23(30)18(16)12-21(17)40-3)35-8-5-19(24(35)36)33-43(38,39)22-13-32-26(42-22)34-9-6-27(28,29)14-34/h4,7,10,12-13,15,19-20,33H,5-6,8-9,11,14H2,1-3H3,(H2,30,31)/t19-,20+/m0/s1 GCYUCXXTANBMJM-VQTJNVASSA-N 182986 US9150544, 20 Coagulation factor X Homo sapiens 630 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182986&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626878 313634397 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330795 COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CC[C@@H](F)C2)C1=O)C(O)=O InChI=1S/C24H27FN6O6S2/c1-37-19-10-16-13(2-5-27-21(16)26)8-14(19)9-18(23(33)34)31-7-4-17(22(31)32)29-39(35,36)20-11-28-24(38-20)30-6-3-15(25)12-30/h2,5,8,10-11,15,17-18,29H,3-4,6-7,9,12H2,1H3,(H2,26,27)(H,33,34)/t15-,17+,18-/m1/s1 UBSFFMVIWJYHAX-BPQIPLTHSA-N 182987 US9150544, 21 Coagulation factor X Homo sapiens 8 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182987&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626879 313634398 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330796 COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(N(C)C)c(C)c2)C1=O)C(O)=O InChI=1S/C25H30N6O6S/c1-14-9-17(13-28-23(14)30(2)3)38(35,36)29-19-6-8-31(24(19)32)20(25(33)34)11-16-10-15-5-7-27-22(26)18(15)12-21(16)37-4/h5,7,9-10,12-13,19-20,29H,6,8,11H2,1-4H3,(H2,26,27)(H,33,34)/t19-,20+/m0/s1 UVLLLCGBOKFHRM-VQTJNVASSA-N 182988 US9150544, 22 Coagulation factor X Homo sapiens 73 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182988&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626880 313634399 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330797 CCOC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1OC)N1CC[C@H](NS(=O)(=O)c2cnc(N(C)C)c(C)c2)C1=O InChI=1S/C27H34N6O6S/c1-6-39-27(35)22(13-18-12-17-7-9-29-24(28)20(17)14-23(18)38-5)33-10-8-21(26(33)34)31-40(36,37)19-11-16(2)25(30-15-19)32(3)4/h7,9,11-12,14-15,21-22,31H,6,8,10,13H2,1-5H3,(H2,28,29)/t21-,22+/m0/s1 AEEBFJAOCZOMFE-FCHUYYIVSA-N 182989 US9150544, 23 Coagulation factor X Homo sapiens 1600 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182989&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626881 313634400 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330798 COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2ccc(nc2)N(C)C)C1=O)C(O)=O InChI=1S/C24H28N6O6S/c1-29(2)21-5-4-16(13-27-21)37(34,35)28-18-7-9-30(23(18)31)19(24(32)33)11-15-10-14-6-8-26-22(25)17(14)12-20(15)36-3/h4-6,8,10,12-13,18-19,28H,7,9,11H2,1-3H3,(H2,25,26)(H,32,33)/t18-,19+/m0/s1 UVBLFSHFVMHKJF-RBUKOAKNSA-N 182990 US9150544, 24 Coagulation factor X Homo sapiens 2 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182990&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626882 313634401 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330799 CCOC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1OC)N1CC[C@H](NS(=O)(=O)c2ccc(nc2)N(C)C)C1=O InChI=1S/C26H32N6O6S/c1-5-38-26(34)21(13-17-12-16-8-10-28-24(27)19(16)14-22(17)37-4)32-11-9-20(25(32)33)30-39(35,36)18-6-7-23(29-15-18)31(2)3/h6-8,10,12,14-15,20-21,30H,5,9,11,13H2,1-4H3,(H2,27,28)/t20-,21+/m0/s1 HLBMCXVPWOZWCN-LEWJYISDSA-N 182991 US9150544, 25 Coagulation factor X Homo sapiens 97 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182991&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626955 313634402 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330800 COc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(N(C)C)c(Cl)c2)C1=O)C(O)=O InChI=1S/C24H27ClN6O6S/c1-30(2)22-17(25)10-15(12-28-22)38(35,36)29-18-5-7-31(23(18)32)19(24(33)34)9-14-8-13-4-6-27-21(26)16(13)11-20(14)37-3/h4,6,8,10-12,18-19,29H,5,7,9H2,1-3H3,(H2,26,27)(H,33,34)/t18-,19+/m0/s1 FINXSQWTTVFKNX-RBUKOAKNSA-N 182992 US9150544, 26 Coagulation factor X Homo sapiens 100 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182992&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626956 313634403 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330801 CN(C)c1ncc(s1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2C)C(O)=O)C1=O InChI=1S/C22H26N6O5S2/c1-12-8-15-13(4-6-24-19(15)23)9-14(12)10-17(21(30)31)28-7-5-16(20(28)29)26-35(32,33)18-11-25-22(34-18)27(2)3/h4,6,8-9,11,16-17,26H,5,7,10H2,1-3H3,(H2,23,24)(H,30,31)/t16-,17+/m0/s1 RQLRLQMOCZXBHM-DLBZAZTESA-N 182994 US9150544, 28 Coagulation factor X Homo sapiens 34 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182994&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626959 313634404 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330802 Cc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCCC2)C1=O)C(O)=O InChI=1S/C24H28N6O5S2/c1-14-10-17-15(4-6-26-21(17)25)11-16(14)12-19(23(32)33)30-9-5-18(22(30)31)28-37(34,35)20-13-27-24(36-20)29-7-2-3-8-29/h4,6,10-11,13,18-19,28H,2-3,5,7-9,12H2,1H3,(H2,25,26)(H,32,33)/t18-,19+/m0/s1 ZUHPACHWDGIPCQ-RBUKOAKNSA-N 182995 US9150544, 29 Coagulation factor X Homo sapiens 150 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182995&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71625960 313634405 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330803 CCc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O)C(O)=O InChI=1S/C23H28N6O5S2/c1-4-13-10-16-14(5-7-25-20(16)24)9-15(13)11-18(22(31)32)29-8-6-17(21(29)30)27-36(33,34)19-12-26-23(35-19)28(2)3/h5,7,9-10,12,17-18,27H,4,6,8,11H2,1-3H3,(H2,24,25)(H,31,32)/t17-,18+/m0/s1 WDERBQGYQKUKDB-ZWKOTPCHSA-N 182996 US9150544, 30 Coagulation factor X Homo sapiens 12 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182996&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71625961 313634406 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330804 CCc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCCC2)C1=O)C(O)=O InChI=1S/C25H30N6O5S2/c1-2-15-12-18-16(5-7-27-22(18)26)11-17(15)13-20(24(33)34)31-10-6-19(23(31)32)29-38(35,36)21-14-28-25(37-21)30-8-3-4-9-30/h5,7,11-12,14,19-20,29H,2-4,6,8-10,13H2,1H3,(H2,26,27)(H,33,34)/t19-,20+/m0/s1 POJHSDHVDLWXCJ-VQTJNVASSA-N 182998 US9150544, 32 Coagulation factor X Homo sapiens 48 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=182998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=182998&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71625963 313634408 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330805 CCc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2ccc(nc2)N(C)C)C1=O)C(O)=O InChI=1S/C25H30N6O5S/c1-4-15-12-19-16(7-9-27-23(19)26)11-17(15)13-21(25(33)34)31-10-8-20(24(31)32)29-37(35,36)18-5-6-22(28-14-18)30(2)3/h5-7,9,11-12,14,20-21,29H,4,8,10,13H2,1-3H3,(H2,26,27)(H,33,34)/t20-,21+/m0/s1 DAVMEQIDLFGLFH-LEWJYISDSA-N 60667 BDBM183000::US9150544, 34 Coagulation factor X Homo sapiens 32 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60667&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626032 316921781 ZINC03032817 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330806 CCc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2ccc(nc2)N2CCCC2)C1=O)C(O)=O InChI=1S/C27H32N6O5S/c1-2-17-14-21-18(7-9-29-25(21)28)13-19(17)15-23(27(35)36)33-12-8-22(26(33)34)31-39(37,38)20-5-6-24(30-16-20)32-10-3-4-11-32/h5-7,9,13-14,16,22-23,31H,2-4,8,10-12,15H2,1H3,(H2,28,29)(H,35,36)/t22-,23+/m0/s1 LTBUHUTYRIJRMR-XZOQPEGZSA-N 183002 US9150544, 36 Coagulation factor X Homo sapiens 470 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183002&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626034 313634411 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330807 CN(C)c1ncc(s1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2F)C(O)=O)C1=O InChI=1S/C21H23FN6O5S2/c1-27(2)21-25-10-17(34-21)35(32,33)26-15-4-6-28(19(15)29)16(20(30)31)8-12-7-11-3-5-24-18(23)13(11)9-14(12)22/h3,5,7,9-10,15-16,26H,4,6,8H2,1-2H3,(H2,23,24)(H,30,31)/t15-,16+/m0/s1 XBUNUDMABSKXMM-JKSUJKDBSA-N 183006 US9150544, 40 Coagulation factor X Homo sapiens 22 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183006&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626089 313634412 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330808 Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCCC4)C3=O)C(O)=O)c(F)cc12 InChI=1S/C23H25FN6O5S2/c24-16-11-15-13(3-5-26-20(15)25)9-14(16)10-18(22(32)33)30-8-4-17(21(30)31)28-37(34,35)19-12-27-23(36-19)29-6-1-2-7-29/h3,5,9,11-12,17-18,28H,1-2,4,6-8,10H2,(H2,25,26)(H,32,33)/t17-,18+/m0/s1 CSGWFHFCQPKNJF-ZWKOTPCHSA-N 183007 US9150544, 41 Coagulation factor X Homo sapiens 47 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183007&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626090 313634413 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330809 Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCC(F)(F)C4)C3=O)C(O)=O)c(F)cc12 InChI=1S/C23H23F3N6O5S2/c24-15-9-14-12(1-4-28-19(14)27)7-13(15)8-17(21(34)35)32-5-2-16(20(32)33)30-39(36,37)18-10-29-22(38-18)31-6-3-23(25,26)11-31/h1,4,7,9-10,16-17,30H,2-3,5-6,8,11H2,(H2,27,28)(H,34,35)/t16-,17+/m0/s1 QBLMCZCTYFJGGT-DLBZAZTESA-N 183008 US9150544, 42 Coagulation factor X Homo sapiens 1200 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183008&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626091 313634414 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330810 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1OC(F)(F)F)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O InChI=1S/C23H25F3N6O6S2/c1-31(2)22-29-11-18(39-22)40(35,36)30-15-5-7-32(20(15)33)16(21(34)37-3)9-13-8-12-4-6-28-19(27)14(12)10-17(13)38-23(24,25)26/h4,6,8,10-11,15-16,30H,5,7,9H2,1-3H3,(H2,27,28)/t15-,16+/m0/s1 SZFZHTXOJIXHBU-JKSUJKDBSA-N 183009 US9150544, 43::US9150544, 77 Coagulation factor X Homo sapiens 60 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183009&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626092 313634415 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330811 CN(C)c1ncc(s1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2OC(F)(F)F)C(O)=O)C1=O InChI=1S/C22H23F3N6O6S2/c1-30(2)21-28-10-17(38-21)39(35,36)29-14-4-6-31(19(14)32)15(20(33)34)8-12-7-11-3-5-27-18(26)13(11)9-16(12)37-22(23,24)25/h3,5,7,9-10,14-15,29H,4,6,8H2,1-2H3,(H2,26,27)(H,33,34)/t14-,15+/m0/s1 BQQOIJPWHPKKRX-LSDHHAIUSA-N 183010 US9150544, 44 Coagulation factor X Homo sapiens 14 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183010&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626093 313634416 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330812 CCOc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O)C(O)=O InChI=1S/C23H28N6O6S2/c1-4-35-18-11-15-13(5-7-25-20(15)24)9-14(18)10-17(22(31)32)29-8-6-16(21(29)30)27-37(33,34)19-12-26-23(36-19)28(2)3/h5,7,9,11-12,16-17,27H,4,6,8,10H2,1-3H3,(H2,24,25)(H,31,32)/t16-,17+/m0/s1 GUUFMKYBWYKLAS-DLBZAZTESA-N 183011 US9150544, 45 Coagulation factor X Homo sapiens 67 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183011&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626151 313634417 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330813 CCOc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCCC2)C1=O)C(O)=O InChI=1S/C25H30N6O6S2/c1-2-37-20-13-17-15(5-7-27-22(17)26)11-16(20)12-19(24(33)34)31-10-6-18(23(31)32)29-39(35,36)21-14-28-25(38-21)30-8-3-4-9-30/h5,7,11,13-14,18-19,29H,2-4,6,8-10,12H2,1H3,(H2,26,27)(H,33,34)/t18-,19+/m0/s1 DEPXLHRQEGGSSJ-RBUKOAKNSA-N 183012 US9150544, 46 Coagulation factor X Homo sapiens 8.4 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183012&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626152 313634418 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330814 CCOc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCC(F)(F)C2)C1=O)C(O)=O InChI=1S/C25H28F2N6O6S2/c1-2-39-19-11-16-14(3-6-29-21(16)28)9-15(19)10-18(23(35)36)33-7-4-17(22(33)34)31-41(37,38)20-12-30-24(40-20)32-8-5-25(26,27)13-32/h3,6,9,11-12,17-18,31H,2,4-5,7-8,10,13H2,1H3,(H2,28,29)(H,35,36)/t17-,18+/m0/s1 RYPKKOBUPPMXJE-ZWKOTPCHSA-N 183013 US9150544, 47 Coagulation factor X Homo sapiens 190 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183013&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626153 313634419 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330815 CN(C)c1ccc(cn1)S(=O)(=O)N[C@H]1CCN(C(Cc2cc3ccnc(N)c3cc2O)C(O)=O)C1=O InChI=1S/C23H26N6O6S/c1-28(2)20-4-3-15(12-26-20)36(34,35)27-17-6-8-29(22(17)31)18(23(32)33)10-14-9-13-5-7-25-21(24)16(13)11-19(14)30/h3-5,7,9,11-12,17-18,27,30H,6,8,10H2,1-2H3,(H2,24,25)(H,32,33)/t17-,18?/m0/s1 PCUGDHAPMBABSD-ZENAZSQFSA-N 183014 US9150544, 48 Coagulation factor X Homo sapiens 6.4 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183014&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 117681979 313634420 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330816 CN(C1CCC1)c1ncc(s1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2Cl)C(O)=O)C1=O InChI=1S/C24H27ClN6O5S2/c1-30(15-3-2-4-15)24-28-12-20(37-24)38(35,36)29-18-6-8-31(22(18)32)19(23(33)34)10-14-9-13-5-7-27-21(26)16(13)11-17(14)25/h5,7,9,11-12,15,18-19,29H,2-4,6,8,10H2,1H3,(H2,26,27)(H,33,34)/t18-,19+/m0/s1 JBMASIMCPHNGJF-RBUKOAKNSA-N 183015 US9150544, 49 Coagulation factor X Homo sapiens 270 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183015&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626155 313634421 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330817 CN(C)c1ncc(s1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2Cl)C(O)=O)C1=O InChI=1S/C21H23ClN6O5S2/c1-27(2)21-25-10-17(34-21)35(32,33)26-15-4-6-28(19(15)29)16(20(30)31)8-12-7-11-3-5-24-18(23)13(11)9-14(12)22/h3,5,7,9-10,15-16,26H,4,6,8H2,1-2H3,(H2,23,24)(H,30,31)/t15-,16+/m0/s1 DYRGULRRGUHACC-JKSUJKDBSA-N 183016 US9150544, 50 Coagulation factor X Homo sapiens 5 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183016&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626214 313634422 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330818 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1Cl)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O InChI=1S/C22H25ClN6O5S2/c1-28(2)22-26-11-18(35-22)36(32,33)27-16-5-7-29(20(16)30)17(21(31)34-3)9-13-8-12-4-6-25-19(24)14(12)10-15(13)23/h4,6,8,10-11,16-17,27H,5,7,9H2,1-3H3,(H2,24,25)/t16-,17+/m0/s1 XIBRERVDEVNLOY-DLBZAZTESA-N 183017 US9150544, 51 Coagulation factor X Homo sapiens 240 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183017&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626215 313634423 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330819 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1Cl)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCCC2)C1=O InChI=1S/C24H27ClN6O5S2/c1-36-23(33)19(11-15-10-14-4-6-27-21(26)16(14)12-17(15)25)31-9-5-18(22(31)32)29-38(34,35)20-13-28-24(37-20)30-7-2-3-8-30/h4,6,10,12-13,18-19,29H,2-3,5,7-9,11H2,1H3,(H2,26,27)/t18-,19+/m0/s1 JACIRYISMLCOOZ-RBUKOAKNSA-N 183018 US9150544, 52 Coagulation factor X Homo sapiens 410 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183018&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626216 313634424 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330820 Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCCC4)C3=O)C(O)=O)c(Cl)cc12 InChI=1S/C23H25ClN6O5S2/c24-16-11-15-13(3-5-26-20(15)25)9-14(16)10-18(22(32)33)30-8-4-17(21(30)31)28-37(34,35)19-12-27-23(36-19)29-6-1-2-7-29/h3,5,9,11-12,17-18,28H,1-2,4,6-8,10H2,(H2,25,26)(H,32,33)/t17-,18+/m0/s1 SYIZRHNKMPFMEA-ZWKOTPCHSA-N 183019 US9150544, 53 Coagulation factor X Homo sapiens 27 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183019&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626217 313634425 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330821 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1OC(F)(F)F)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCCC2)C1=O InChI=1S/C25H27F3N6O6S2/c1-39-23(36)18(11-15-10-14-4-6-30-21(29)16(14)12-19(15)40-25(26,27)28)34-9-5-17(22(34)35)32-42(37,38)20-13-31-24(41-20)33-7-2-3-8-33/h4,6,10,12-13,17-18,32H,2-3,5,7-9,11H2,1H3,(H2,29,30)/t17-,18+/m0/s1 LTEGXTZXBWOHGG-ZWKOTPCHSA-N 183020 US9150544, 54 Coagulation factor X Homo sapiens 1120 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183020&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626218 313634426 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330822 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1OC(F)(F)F)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCC(F)(F)C2)C1=O InChI=1S/C25H25F5N6O6S2/c1-41-22(38)17(9-14-8-13-2-5-32-20(31)15(13)10-18(14)42-25(28,29)30)36-6-3-16(21(36)37)34-44(39,40)19-11-33-23(43-19)35-7-4-24(26,27)12-35/h2,5,8,10-11,16-17,34H,3-4,6-7,9,12H2,1H3,(H2,31,32)/t16-,17+/m0/s1 WVTNAMRPXVDFLQ-DLBZAZTESA-N 183021 US9150544, 55 Coagulation factor X Homo sapiens 6120 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183021&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626274 313634427 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330823 Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCC(F)(F)C4)C3=O)C(O)=O)c(OC(F)(F)F)cc12 InChI=1S/C24H23F5N6O6S2/c25-23(26)3-6-34(11-23)22-32-10-18(42-22)43(39,40)33-15-2-5-35(20(15)36)16(21(37)38)8-13-7-12-1-4-31-19(30)14(12)9-17(13)41-24(27,28)29/h1,4,7,9-10,15-16,33H,2-3,5-6,8,11H2,(H2,30,31)(H,37,38)/t15-,16+/m0/s1 GGYAYBPGFQCTME-JKSUJKDBSA-N 183022 US9150544, 56 Coagulation factor X Homo sapiens 560 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183022&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626275 313634428 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330824 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1OC(F)(F)F)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCC2)C1=O InChI=1S/C24H25F3N6O6S2/c1-38-22(35)17(10-14-9-13-3-5-29-20(28)15(13)11-18(14)39-24(25,26)27)33-8-4-16(21(33)34)31-41(36,37)19-12-30-23(40-19)32-6-2-7-32/h3,5,9,11-12,16-17,31H,2,4,6-8,10H2,1H3,(H2,28,29)/t16-,17+/m0/s1 KZEPWUVKJXTJRL-DLBZAZTESA-N 183023 US9150544, 57 Coagulation factor X Homo sapiens 1970 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183023&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626276 313634429 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330825 Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCC4)C3=O)C(O)=O)c(OC(F)(F)F)cc12 InChI=1S/C23H23F3N6O6S2/c24-23(25,26)38-17-10-14-12(2-4-28-19(14)27)8-13(17)9-16(21(34)35)32-7-3-15(20(32)33)30-40(36,37)18-11-29-22(39-18)31-5-1-6-31/h2,4,8,10-11,15-16,30H,1,3,5-7,9H2,(H2,27,28)(H,34,35)/t15-,16+/m0/s1 DYMJVFQUJWVIAD-JKSUJKDBSA-N 183024 US9150544, 58 Coagulation factor X Homo sapiens 35 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183024&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626277 313634430 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330826 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1OC(F)(F)F)N1CC[C@H](NS(=O)(=O)c2ccc(nc2)N(C)C)C1=O InChI=1S/C25H27F3N6O6S/c1-33(2)21-5-4-16(13-31-21)41(37,38)32-18-7-9-34(23(18)35)19(24(36)39-3)11-15-10-14-6-8-30-22(29)17(14)12-20(15)40-25(26,27)28/h4-6,8,10,12-13,18-19,32H,7,9,11H2,1-3H3,(H2,29,30)/t18-,19+/m0/s1 WUUVDHVYCJVNHJ-RBUKOAKNSA-N 183025 US9150544, 59 Coagulation factor X Homo sapiens 1090 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183025&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626336 313634431 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330827 CN(C)c1ccc(cn1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2OC(F)(F)F)C(O)=O)C1=O InChI=1S/C24H25F3N6O6S/c1-32(2)20-4-3-15(12-30-20)40(37,38)31-17-6-8-33(22(17)34)18(23(35)36)10-14-9-13-5-7-29-21(28)16(13)11-19(14)39-24(25,26)27/h3-5,7,9,11-12,17-18,31H,6,8,10H2,1-2H3,(H2,28,29)(H,35,36)/t17-,18+/m0/s1 ZZCAKOUFQSCCCF-ZWKOTPCHSA-N 183026 US9150544, 60 Coagulation factor X Homo sapiens 34 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183026&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626337 313634432 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330828 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1Cl)N1CC[C@H](NS(=O)(=O)c2ccc(nc2)N(C)C)C1=O InChI=1S/C24H27ClN6O5S/c1-30(2)21-5-4-16(13-28-21)37(34,35)29-19-7-9-31(23(19)32)20(24(33)36-3)11-15-10-14-6-8-27-22(26)17(14)12-18(15)25/h4-6,8,10,12-13,19-20,29H,7,9,11H2,1-3H3,(H2,26,27)/t19-,20+/m0/s1 XIKIVOVOHHNTKK-VQTJNVASSA-N 183027 US9150544, 61 Coagulation factor X Homo sapiens 470 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183027&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626338 313634433 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330829 CN(C)c1ccc(cn1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2Cl)C(O)=O)C1=O InChI=1S/C23H25ClN6O5S/c1-29(2)20-4-3-15(12-27-20)36(34,35)28-18-6-8-30(22(18)31)19(23(32)33)10-14-9-13-5-7-26-21(25)16(13)11-17(14)24/h3-5,7,9,11-12,18-19,28H,6,8,10H2,1-2H3,(H2,25,26)(H,32,33)/t18-,19+/m0/s1 ORPCYBIXIFWZDJ-RBUKOAKNSA-N 183028 US9150544, 62 Coagulation factor X Homo sapiens 16 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183028&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626339 313634434 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330830 CN(C)c1ccc(cn1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2F)C(O)=O)C1=O InChI=1S/C23H25FN6O5S/c1-29(2)20-4-3-15(12-27-20)36(34,35)28-18-6-8-30(22(18)31)19(23(32)33)10-14-9-13-5-7-26-21(25)16(13)11-17(14)24/h3-5,7,9,11-12,18-19,28H,6,8,10H2,1-2H3,(H2,25,26)(H,32,33)/t18-,19+/m0/s1 SZUJJQUYAIDMRR-RBUKOAKNSA-N 183029 US9150544, 63 Coagulation factor X Homo sapiens 42 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183029&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626340 313634435 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330831 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1F)N1CC[C@H](NS(=O)(=O)c2ccc(nc2)N(C)C)C1=O InChI=1S/C24H27FN6O5S/c1-30(2)21-5-4-16(13-28-21)37(34,35)29-19-7-9-31(23(19)32)20(24(33)36-3)11-15-10-14-6-8-27-22(26)17(14)12-18(15)25/h4-6,8,10,12-13,19-20,29H,7,9,11H2,1-3H3,(H2,26,27)/t19-,20+/m0/s1 XPRWUIUHWBFRAY-VQTJNVASSA-N 183030 US9150544, 64 Coagulation factor X Homo sapiens 400 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183030&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626401 313634436 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330832 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1Cl)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCC(F)(F)C2)C1=O InChI=1S/C24H25ClF2N6O5S2/c1-38-22(35)18(9-14-8-13-2-5-29-20(28)15(13)10-16(14)25)33-6-3-17(21(33)34)31-40(36,37)19-11-30-23(39-19)32-7-4-24(26,27)12-32/h2,5,8,10-11,17-18,31H,3-4,6-7,9,12H2,1H3,(H2,28,29)/t17-,18+/m0/s1 JUNXSIBFIARCRB-ZWKOTPCHSA-N 183031 US9150544, 65 Coagulation factor X Homo sapiens 5500 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183031&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626402 313634437 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330833 Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCC(F)(F)C4)C3=O)C(O)=O)c(Cl)cc12 InChI=1S/C23H23ClF2N6O5S2/c24-15-9-14-12(1-4-28-19(14)27)7-13(15)8-17(21(34)35)32-5-2-16(20(32)33)30-39(36,37)18-10-29-22(38-18)31-6-3-23(25,26)11-31/h1,4,7,9-10,16-17,30H,2-3,5-6,8,11H2,(H2,27,28)(H,34,35)/t16-,17+/m0/s1 ALCAZULJAWNTIU-DLBZAZTESA-N 183032 US9150544, 66 Coagulation factor X Homo sapiens 190 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183032&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626403 313634438 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330834 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1F)N1CC[C@H](NS(=O)(=O)c2cnc(N(C)C)c(Cl)c2)C1=O InChI=1S/C24H26ClFN6O5S/c1-31(2)22-17(25)10-15(12-29-22)38(35,36)30-19-5-7-32(23(19)33)20(24(34)37-3)9-14-8-13-4-6-28-21(27)16(13)11-18(14)26/h4,6,8,10-12,19-20,30H,5,7,9H2,1-3H3,(H2,27,28)/t19-,20+/m0/s1 MJYAEKTZMOJSNM-VQTJNVASSA-N 183033 US9150544, 67 Coagulation factor X Homo sapiens 3850 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183033&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626404 313634439 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330835 CN(C)c1ncc(cc1Cl)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2F)C(O)=O)C1=O InChI=1S/C23H24ClFN6O5S/c1-30(2)21-16(24)9-14(11-28-21)37(35,36)29-18-4-6-31(22(18)32)19(23(33)34)8-13-7-12-3-5-27-20(26)15(12)10-17(13)25/h3,5,7,9-11,18-19,29H,4,6,8H2,1-2H3,(H2,26,27)(H,33,34)/t18-,19+/m0/s1 MMKNYJALKTVJIC-RBUKOAKNSA-N 183034 US9150544, 68 Coagulation factor X Homo sapiens 1910 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183034&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626405 313634440 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330836 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1Cl)N1CC[C@H](NS(=O)(=O)c2cnc(N(C)C)c(Cl)c2)C1=O InChI=1S/C24H26Cl2N6O5S/c1-31(2)22-18(26)10-15(12-29-22)38(35,36)30-19-5-7-32(23(19)33)20(24(34)37-3)9-14-8-13-4-6-28-21(27)16(13)11-17(14)25/h4,6,8,10-12,19-20,30H,5,7,9H2,1-3H3,(H2,27,28)/t19-,20+/m0/s1 GYDKAFSDTLMPEP-VQTJNVASSA-N 183035 US9150544, 69 Coagulation factor X Homo sapiens 3850 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183035&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626473 313634441 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330837 CN(C)c1ncc(cc1Cl)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2Cl)C(O)=O)C1=O InChI=1S/C23H24Cl2N6O5S/c1-30(2)21-17(25)9-14(11-28-21)37(35,36)29-18-4-6-31(22(18)32)19(23(33)34)8-13-7-12-3-5-27-20(26)15(12)10-16(13)24/h3,5,7,9-11,18-19,29H,4,6,8H2,1-2H3,(H2,26,27)(H,33,34)/t18-,19+/m0/s1 KLFSLDKLJLSVFR-RBUKOAKNSA-N 183036 US9150544, 70 Coagulation factor X Homo sapiens 590 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183036&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626474 313634442 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330838 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1OC(F)(F)F)N1CC[C@H](NS(=O)(=O)c2cnc(N(C)C)c(C)c2)C1=O InChI=1S/C26H29F3N6O6S/c1-14-9-17(13-32-23(14)34(2)3)42(38,39)33-19-6-8-35(24(19)36)20(25(37)40-4)11-16-10-15-5-7-31-22(30)18(15)12-21(16)41-26(27,28)29/h5,7,9-10,12-13,19-20,33H,6,8,11H2,1-4H3,(H2,30,31)/t19-,20+/m0/s1 PIKIUPTYUQSXJU-VQTJNVASSA-N 183038 US9150544, 72 Coagulation factor X Homo sapiens 5450 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183038&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626476 313634444 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330839 CN(C)c1ncc(cc1C)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2F)C(O)=O)C1=O InChI=1S/C24H27FN6O5S/c1-13-8-16(12-28-22(13)30(2)3)37(35,36)29-19-5-7-31(23(19)32)20(24(33)34)10-15-9-14-4-6-27-21(26)17(14)11-18(15)25/h4,6,8-9,11-12,19-20,29H,5,7,10H2,1-3H3,(H2,26,27)(H,33,34)/t19-,20+/m0/s1 XAFKLXZJDNZCCE-VQTJNVASSA-N 183039 US9150544, 73 Coagulation factor X Homo sapiens 2770 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183039&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626477 313634445 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330840 CN(C)c1ncc(cc1C)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2OC(F)(F)F)C(O)=O)C1=O InChI=1S/C25H27F3N6O6S/c1-13-8-16(12-31-22(13)33(2)3)41(38,39)32-18-5-7-34(23(18)35)19(24(36)37)10-15-9-14-4-6-30-21(29)17(14)11-20(15)40-25(26,27)28/h4,6,8-9,11-12,18-19,32H,5,7,10H2,1-3H3,(H2,29,30)(H,36,37)/t18-,19+/m0/s1 PMQKOMRVCJPMLV-RBUKOAKNSA-N 183040 US9150544, 74 Coagulation factor X Homo sapiens 810 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183040&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626540 313634446 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330841 CN(C)c1ncc(cc1C)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2Cl)C(O)=O)C1=O InChI=1S/C24H27ClN6O5S/c1-13-8-16(12-28-22(13)30(2)3)37(35,36)29-19-5-7-31(23(19)32)20(24(33)34)10-15-9-14-4-6-27-21(26)17(14)11-18(15)25/h4,6,8-9,11-12,19-20,29H,5,7,10H2,1-3H3,(H2,26,27)(H,33,34)/t19-,20+/m0/s1 QHLZKZFIYMQOKP-VQTJNVASSA-N 183042 US9150544, 76 Coagulation factor X Homo sapiens 650 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183042&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626542 313634448 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330842 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1OC(F)(F)F)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O InChI=1S/C23H25F3N6O6S2/c1-31(2)22-29-11-18(39-22)40(35,36)30-15-5-7-32(20(15)33)16(21(34)37-3)9-13-8-12-4-6-28-19(27)14(12)10-17(13)38-23(24,25)26/h4,6,8,10-11,15-16,30H,5,7,9H2,1-3H3,(H2,27,28)/t15-,16+/m0/s1 SZFZHTXOJIXHBU-JKSUJKDBSA-N 183009 US9150544, 43::US9150544, 77 Coagulation factor X Homo sapiens 110 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183009&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626092 313634415 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330843 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1C(F)(F)F)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O InChI=1S/C23H25F3N6O5S2/c1-31(2)22-29-11-18(38-22)39(35,36)30-16-5-7-32(20(16)33)17(21(34)37-3)9-13-8-12-4-6-28-19(27)14(12)10-15(13)23(24,25)26/h4,6,8,10-11,16-17,30H,5,7,9H2,1-3H3,(H2,27,28)/t16-,17+/m0/s1 BSGNZKXOPXXCFR-DLBZAZTESA-N 183044 US9150544, 78 Coagulation factor X Homo sapiens 800 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183044&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626543 313634449 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330844 CN(C)c1ncc(s1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2C(F)(F)F)C(O)=O)C1=O InChI=1S/C22H23F3N6O5S2/c1-30(2)21-28-10-17(37-21)38(35,36)29-15-4-6-31(19(15)32)16(20(33)34)8-12-7-11-3-5-27-18(26)13(11)9-14(12)22(23,24)25/h3,5,7,9-10,15-16,29H,4,6,8H2,1-2H3,(H2,26,27)(H,33,34)/t15-,16+/m0/s1 RWYVWVGDZRZFTC-JKSUJKDBSA-N 183045 US9150544, 79 Coagulation factor X Homo sapiens 33 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183045&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626544 313634450 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330845 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1C(F)(F)F)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCCC2)C1=O InChI=1S/C25H27F3N6O5S2/c1-39-23(36)19(11-15-10-14-4-6-30-21(29)16(14)12-17(15)25(26,27)28)34-9-5-18(22(34)35)32-41(37,38)20-13-31-24(40-20)33-7-2-3-8-33/h4,6,10,12-13,18-19,32H,2-3,5,7-9,11H2,1H3,(H2,29,30)/t18-,19+/m0/s1 FKKRIFGOJQHROR-RBUKOAKNSA-N 183046 US9150544, 80 Coagulation factor X Homo sapiens 3230 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183046&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626613 313634451 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330846 Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCCC4)C3=O)C(O)=O)c(cc12)C(F)(F)F InChI=1S/C24H25F3N6O5S2/c25-24(26,27)16-11-15-13(3-5-29-20(15)28)9-14(16)10-18(22(35)36)33-8-4-17(21(33)34)31-40(37,38)19-12-30-23(39-19)32-6-1-2-7-32/h3,5,9,11-12,17-18,31H,1-2,4,6-8,10H2,(H2,28,29)(H,35,36)/t17-,18+/m0/s1 VZTGHAQSALBFJS-ZWKOTPCHSA-N 183047 US9150544, 81 Coagulation factor X Homo sapiens 370 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183047&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626614 313634452 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330847 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1C(F)(F)F)N1CC[C@H](NS(=O)(=O)c2ccc(nc2)N(C)C)C1=O InChI=1S/C25H27F3N6O5S/c1-33(2)21-5-4-16(13-31-21)40(37,38)32-19-7-9-34(23(19)35)20(24(36)39-3)11-15-10-14-6-8-30-22(29)17(14)12-18(15)25(26,27)28/h4-6,8,10,12-13,19-20,32H,7,9,11H2,1-3H3,(H2,29,30)/t19-,20+/m0/s1 QUHDVEMLJSUFHS-VQTJNVASSA-N 183048 US9150544, 82 Coagulation factor X Homo sapiens 2430 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183048&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626615 313634453 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330848 CN(C)c1ccc(cn1)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2C(F)(F)F)C(O)=O)C1=O InChI=1S/C24H25F3N6O5S/c1-32(2)20-4-3-15(12-30-20)39(37,38)31-18-6-8-33(22(18)34)19(23(35)36)10-14-9-13-5-7-29-21(28)16(13)11-17(14)24(25,26)27/h3-5,7,9,11-12,18-19,31H,6,8,10H2,1-2H3,(H2,28,29)(H,35,36)/t18-,19+/m0/s1 SNMOFBUTBIIIQV-RBUKOAKNSA-N 183049 US9150544, 83 Coagulation factor X Homo sapiens 240 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183049&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 89644406 313634454 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330849 CCOC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1Cl)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCCC2)C1=O InChI=1S/C25H29ClN6O5S2/c1-2-37-24(34)20(12-16-11-15-5-7-28-22(27)17(15)13-18(16)26)32-10-6-19(23(32)33)30-39(35,36)21-14-29-25(38-21)31-8-3-4-9-31/h5,7,11,13-14,19-20,30H,2-4,6,8-10,12H2,1H3,(H2,27,28)/t19-,20+/m0/s1 UCOCEOONAULCKX-VQTJNVASSA-N 183050 US9150544, 84 Coagulation factor X Homo sapiens 940 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183050&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626616 313634455 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330850 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1Cl)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCC2)C1=O InChI=1S/C23H25ClN6O5S2/c1-35-22(32)18(10-14-9-13-3-5-26-20(25)15(13)11-16(14)24)30-8-4-17(21(30)31)28-37(33,34)19-12-27-23(36-19)29-6-2-7-29/h3,5,9,11-12,17-18,28H,2,4,6-8,10H2,1H3,(H2,25,26)/t17-,18+/m0/s1 XIRBPKXBCLXGPB-ZWKOTPCHSA-N 183051 US9150544, 85 Coagulation factor X Homo sapiens 780 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183051&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626617 313634456 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330851 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1OC(F)(F)F)N1CC[C@H](NS(=O)(=O)c2cnc(N(C)C)c(Cl)c2)C1=O InChI=1S/C25H26ClF3N6O6S/c1-34(2)22-17(26)10-15(12-32-22)42(38,39)33-18-5-7-35(23(18)36)19(24(37)40-3)9-14-8-13-4-6-31-21(30)16(13)11-20(14)41-25(27,28)29/h4,6,8,10-12,18-19,33H,5,7,9H2,1-3H3,(H2,30,31)/t18-,19+/m0/s1 KSZGZPHHCGNFER-RBUKOAKNSA-N 183052 US9150544, 86 Coagulation factor X Homo sapiens 2840 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183052&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626682 313634457 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330852 CN(C)c1ncc(cc1Cl)S(=O)(=O)N[C@H]1CCN([C@H](Cc2cc3ccnc(N)c3cc2OC(F)(F)F)C(O)=O)C1=O InChI=1S/C24H24ClF3N6O6S/c1-33(2)21-16(25)9-14(11-31-21)41(38,39)32-17-4-6-34(22(17)35)18(23(36)37)8-13-7-12-3-5-30-20(29)15(12)10-19(13)40-24(26,27)28/h3,5,7,9-11,17-18,32H,4,6,8H2,1-2H3,(H2,29,30)(H,36,37)/t17-,18+/m0/s1 LERNDWIYHSCVBK-ZWKOTPCHSA-N 183053 US9150544, 87 Coagulation factor X Homo sapiens 1650 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183053&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626683 313634458 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330853 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1C(F)(F)F)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCC2)C1=O InChI=1S/C24H25F3N6O5S2/c1-38-22(35)18(10-14-9-13-3-5-29-20(28)15(13)11-16(14)24(25,26)27)33-8-4-17(21(33)34)31-40(36,37)19-12-30-23(39-19)32-6-2-7-32/h3,5,9,11-12,17-18,31H,2,4,6-8,10H2,1H3,(H2,28,29)/t17-,18+/m0/s1 CYDWBJDGJSCSFH-ZWKOTPCHSA-N 183054 US9150544, 88 Coagulation factor X Homo sapiens 3080 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183054&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626684 313634459 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330854 Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCC4)C3=O)C(O)=O)c(cc12)C(F)(F)F InChI=1S/C23H23F3N6O5S2/c24-23(25,26)15-10-14-12(2-4-28-19(14)27)8-13(15)9-17(21(34)35)32-7-3-16(20(32)33)30-39(36,37)18-11-29-22(38-18)31-5-1-6-31/h2,4,8,10-11,16-17,30H,1,3,5-7,9H2,(H2,27,28)(H,34,35)/t16-,17+/m0/s1 WCNFGOBCQACIGW-DLBZAZTESA-N 183055 US9150544, 89 Coagulation factor X Homo sapiens 560 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183055&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626685 313634460 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330855 Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCC(F)(F)C4)C3=O)C(O)=O)c(cc12)C(F)(F)F InChI=1S/C24H23F5N6O5S2/c25-23(26)3-6-34(11-23)22-32-10-18(41-22)42(39,40)33-16-2-5-35(20(16)36)17(21(37)38)8-13-7-12-1-4-31-19(30)14(12)9-15(13)24(27,28)29/h1,4,7,9-10,16-17,33H,2-3,5-6,8,11H2,(H2,30,31)(H,37,38)/t16-,17+/m0/s1 XRSGFSZNARETKV-DLBZAZTESA-N 183057 US9150544, 91 Coagulation factor X Homo sapiens 2180 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183057&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626751 313634462 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330856 Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCC4)C3=O)C(O)=O)c(Cl)cc12 InChI=1S/C22H23ClN6O5S2/c23-15-10-14-12(2-4-25-19(14)24)8-13(15)9-17(21(31)32)29-7-3-16(20(29)30)27-36(33,34)18-11-26-22(35-18)28-5-1-6-28/h2,4,8,10-11,16-17,27H,1,3,5-7,9H2,(H2,24,25)(H,31,32)/t16-,17+/m0/s1 CQOCPYQVKHQTQU-DLBZAZTESA-N 183058 US9150544, 92 Coagulation factor X Homo sapiens 19 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183058&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626752 313634463 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330857 CCCCOC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1Cl)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCCC2)C1=O InChI=1S/C27H33ClN6O5S2/c1-2-3-12-39-26(36)22(14-18-13-17-6-8-30-24(29)19(17)15-20(18)28)34-11-7-21(25(34)35)32-41(37,38)23-16-31-27(40-23)33-9-4-5-10-33/h6,8,13,15-16,21-22,32H,2-5,7,9-12,14H2,1H3,(H2,29,30)/t21-,22+/m0/s1 VIMRVAKOLBCXBX-FCHUYYIVSA-N 183059 US9150544, 93 Coagulation factor X Homo sapiens 1000 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183059&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626753 313634464 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330858 COC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1C#N)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N2CCCC2)C1=O InChI=1S/C25H27N7O5S2/c1-37-24(34)20(12-16-10-15-4-6-28-22(27)18(15)11-17(16)13-26)32-9-5-19(23(32)33)30-39(35,36)21-14-29-25(38-21)31-7-2-3-8-31/h4,6,10-11,14,19-20,30H,2-3,5,7-9,12H2,1H3,(H2,27,28)/t19-,20+/m0/s1 LLXHMJZTRPAHDM-VQTJNVASSA-N 183060 US9150544, 94 Coagulation factor X Homo sapiens 1060 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183060&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71626754 313634465 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330859 Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCCC4)C3=O)C(O)=O)c(cc12)C#N InChI=1S/C24H25N7O5S2/c25-12-16-10-17-14(3-5-27-21(17)26)9-15(16)11-19(23(33)34)31-8-4-18(22(31)32)29-38(35,36)20-13-28-24(37-20)30-6-1-2-7-30/h3,5,9-10,13,18-19,29H,1-2,4,6-8,11H2,(H2,26,27)(H,33,34)/t18-,19+/m0/s1 ORCHICABHKIDCE-RBUKOAKNSA-N 183061 US9150544, 95 Coagulation factor X Homo sapiens 25 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183061&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 89644327 313634466 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330860 Nc1nccc2cc(C[C@@H](N3CC[C@H](NS(=O)(=O)c4cnc(s4)N4CCCC4)C3=O)C(O)=O)c(OC(F)(F)F)cc12 InChI=1S/C24H25F3N6O6S2/c25-24(26,27)39-18-11-15-13(3-5-29-20(15)28)9-14(18)10-17(22(35)36)33-8-4-16(21(33)34)31-41(37,38)19-12-30-23(40-19)32-6-1-2-7-32/h3,5,9,11-12,16-17,31H,1-2,4,6-8,10H2,(H2,28,29)(H,35,36)/t16-,17+/m0/s1 ONHZVHMZTKZTFT-DLBZAZTESA-N 183062 US9150544, 96 Coagulation factor X Homo sapiens 42 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183062&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71584488 313634467 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330861 CCOC(=O)[C@@H](Cc1cc2ccnc(N)c2cc1OCCOC)N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O InChI=1S/C26H34N6O7S2/c1-5-38-25(34)20(13-17-12-16-6-8-28-23(27)18(16)14-21(17)39-11-10-37-4)32-9-7-19(24(32)33)30-41(35,36)22-15-29-26(40-22)31(2)3/h6,8,12,14-15,19-20,30H,5,7,9-11,13H2,1-4H3,(H2,27,28)/t19-,20+/m0/s1 UIIJMUGOGFMNFD-VQTJNVASSA-N 183068 US9150544, 102 Coagulation factor X Homo sapiens 37 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183068&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 89644112 313634468 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 330862 COCCOc1cc2c(N)nccc2cc1C[C@@H](N1CC[C@H](NS(=O)(=O)c2cnc(s2)N(C)C)C1=O)C(O)=O InChI=1S/C24H30N6O7S2/c1-29(2)24-27-13-20(38-24)39(34,35)28-17-5-7-30(22(17)31)18(23(32)33)11-15-10-14-4-6-26-21(25)16(14)12-19(15)37-9-8-36-3/h4,6,10,12-13,17-18,28H,5,7-9,11H2,1-3H3,(H2,25,26)(H,32,33)/t17-,18+/m0/s1 KEHAQUINLNOUGX-ZWKOTPCHSA-N 183069 US9150544, 103 Coagulation factor X Homo sapiens 1.4 7 US Patent 10.7270/Q27S7MKF aid1801697 US9150544 Alet, N; Altenburger, J; Herault, J; Kirsch, R; Lassalle, G; Mallart, S; Philippo-Orts, M Sanofi http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183069&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 89644163 313634469 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 346875 CN(C)C(=N)c1ccc(cc1)C(=O)Nc1ccc(OCC(=O)NCCCCCCN)cc1C(=O)Nc1ccccn1 InChI=1S/C30H37N7O4/c1-37(2)28(32)21-10-12-22(13-11-21)29(39)35-25-15-14-23(41-20-27(38)34-18-7-4-3-6-16-31)19-24(25)30(40)36-26-9-5-8-17-33-26/h5,8-15,17,19,32H,3-4,6-7,16,18,20,31H2,1-2H3,(H,34,38)(H,35,39)(H,33,36,40) SQUCCHIATSTSKW-UHFFFAOYSA-N 194505 US9200268, Table 4, Compound 1 Coagulation factor X Homo sapiens 227 7.4 25.00 C US Patent 10.7270/Q2PV6J61 aid1801962 US9200268 Pandey, A; Rose, JW Portola Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=194505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=194505&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 76902900 318123700 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 346876 CN(C)C(=N)c1ccc(cc1)C(=O)Nc1ccc(OCC(=O)NCCCCCCN)cc1C(=O)Nc1ccc(Cl)cn1 InChI=1S/C30H36ClN7O4/c1-38(2)28(33)20-7-9-21(10-8-20)29(40)36-25-13-12-23(42-19-27(39)34-16-6-4-3-5-15-32)17-24(25)30(41)37-26-14-11-22(31)18-35-26/h7-14,17-18,33H,3-6,15-16,19,32H2,1-2H3,(H,34,39)(H,36,40)(H,35,37,41) QQGACZCZSKTPRJ-UHFFFAOYSA-N 194506 US9200268, Table 4, Compound 2 Coagulation factor X Homo sapiens 24 7.4 25.00 C US Patent 10.7270/Q2PV6J61 aid1801962 US9200268 Pandey, A; Rose, JW Portola Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=194506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=194506&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 76902899 318123701 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 346877 NCCCCCCNc1cc(ccc1C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1)C(F)(F)F InChI=1S/C26H26Cl2F3N5O2/c27-17-6-9-21(20(14-17)25(38)36-23-10-7-18(28)15-34-23)35-24(37)19-8-5-16(26(29,30)31)13-22(19)33-12-4-2-1-3-11-32/h5-10,13-15,33H,1-4,11-12,32H2,(H,35,37)(H,34,36,38) WUTYKZPJCNQSOU-UHFFFAOYSA-N 194507 US9200268, Table 4, Compound 3 Coagulation factor X Homo sapiens 615 7.4 25.00 C US Patent 10.7270/Q2PV6J61 aid1801962 US9200268 Pandey, A; Rose, JW Portola Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=194507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=194507&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 76903279 318123702 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 346878 CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c(NCCCCCCN)c1 InChI=1S/C26H29Cl2N5O4S/c1-38(36,37)19-8-9-20(23(15-19)30-13-5-3-2-4-12-29)25(34)32-22-10-6-17(27)14-21(22)26(35)33-24-11-7-18(28)16-31-24/h6-11,14-16,30H,2-5,12-13,29H2,1H3,(H,32,34)(H,31,33,35) BPCLMRQCMSZQGT-UHFFFAOYSA-N 194508 US9200268, Table 4, Compound 4 Coagulation factor X Homo sapiens 158 7.4 25.00 C US Patent 10.7270/Q2PV6J61 aid1801962 US9200268 Pandey, A; Rose, JW Portola Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=194508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=194508&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 76903281 318123703 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 346879 CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c(NCCCCCCCN)c1 InChI=1S/C27H31Cl2N5O4S/c1-39(37,38)20-9-10-21(24(16-20)31-14-6-4-2-3-5-13-30)26(35)33-23-11-7-18(28)15-22(23)27(36)34-25-12-8-19(29)17-32-25/h7-12,15-17,31H,2-6,13-14,30H2,1H3,(H,33,35)(H,32,34,36) VMISJPSUUHMJHG-UHFFFAOYSA-N 194509 US9200268, Table 4, Compound 5 Coagulation factor X Homo sapiens 320 7.4 25.00 C US Patent 10.7270/Q2PV6J61 aid1801962 US9200268 Pandey, A; Rose, JW Portola Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=194509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=194509&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 76903282 318123704 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 356165 CCOc1ccc(C[C@@H](NC(=O)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCc2ccc(CN)cc2)cc1 InChI=1S/C35H38N4O4/c1-2-43-30-19-17-26(18-20-30)22-32(38-33(40)29-11-7-4-8-12-29)35(42)39-31(21-25-9-5-3-6-10-25)34(41)37-24-28-15-13-27(23-36)14-16-28/h3-20,31-32H,2,21-24,36H2,1H3,(H,37,41)(H,38,40)(H,39,42)/t31-,32+/m0/s1 UCIXIQRCAGGOJY-AJQTZOPKSA-N 200012 US9234000, 3::US9512065, N-[(R)-1-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-(4-ethoxy-phenyl)-ethyl]-benzamide Coagulation factor X Homo sapiens >10000 US Patent 10.7270/Q2X065W0 aid1802101 US9234000 Evans, DM; Davie, RL; Edwards, HJ; Rooker, DP Kalvista Pharmaceuticals Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=200012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=200012&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71185716 318589842 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395714 COC(=O)CN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)c1ccc2cc(Cl)ccc2c1 InChI=1S/C24H28ClN3O7S/c1-16(23(30)26-9-11-35-12-10-26)27-8-7-21(24(27)31)28(15-22(29)34-2)36(32,33)20-6-4-17-13-19(25)5-3-18(17)14-20/h3-6,13-14,16,21H,7-12,15H2,1-2H3/t16-,21-/m0/s1 ODQASWVTSCKYSN-KKSFZXQISA-N 226017 GTC000001A Coagulation factor X Homo sapiens 10.5 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226017&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10187090 336293166 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395715 C[C@H](N1CC[C@H](N(CC(O)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C23H26ClN3O7S/c1-15(22(30)25-8-10-34-11-9-25)26-7-6-20(23(26)31)27(14-21(28)29)35(32,33)19-5-3-16-12-18(24)4-2-17(16)13-19/h2-5,12-13,15,20H,6-11,14H2,1H3,(H,28,29)/t15-,20-/m0/s1 UAYCGHBBLVJXTC-YWZLYKJASA-N 12567 2-[(6-chloronaphthalene-2-)[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]sulfonamido]acetic acid::GTC000002A::pyrrolidin-2-one-based inhibitor 26 Coagulation factor X Homo sapiens 14.3 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12567&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10142920 46513025 ZINC14950158 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395716 C[C@H](N1CC[C@H](N(CC#N)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C23H25ClN4O5S/c1-16(22(29)26-10-12-33-13-11-26)27-8-6-21(23(27)30)28(9-7-25)34(31,32)20-5-3-17-14-19(24)4-2-18(17)15-20/h2-5,14-16,21H,6,8-13H2,1H3/t16-,21-/m0/s1 MMFJBPKSIQNYKR-KKSFZXQISA-N 226018 GTC000003A Coagulation factor X Homo sapiens 22.5 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226018&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10278908 336293167 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395717 C[C@H](N1CC[C@H](N(CC=C)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C24H28ClN3O5S/c1-3-9-28(34(31,32)21-7-5-18-15-20(25)6-4-19(18)16-21)22-8-10-27(24(22)30)17(2)23(29)26-11-13-33-14-12-26/h3-7,15-17,22H,1,8-14H2,2H3/t17-,22-/m0/s1 RNTZYYFNYQXYPX-JTSKRJEESA-N 226019 GTC000004A Coagulation factor X Homo sapiens 67 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226019&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10118127 336293168 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395718 C[C@H](N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C23H27ClN4O6S/c1-15(22(30)26-8-10-34-11-9-26)27-7-6-20(23(27)31)28(14-21(25)29)35(32,33)19-5-3-16-12-18(24)4-2-17(16)13-19/h2-5,12-13,15,20H,6-11,14H2,1H3,(H2,25,29)/t15-,20-/m0/s1 DRTYVXQQGDRUEW-YWZLYKJASA-N 12568 2-[(6-chloronaphthalene-2-)[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]sulfonamido]acetamide::GTC000005A::pyrrolidin-2-one-based inhibitor 27 Coagulation factor X Homo sapiens 21.2 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12568&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10301730 46513026 ZINC14950162 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395719 CCC(=O)CN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)c1ccc2cc(Cl)ccc2c1 InChI=1S/C25H30ClN3O6S/c1-3-21(30)16-29(36(33,34)22-7-5-18-14-20(26)6-4-19(18)15-22)23-8-9-28(25(23)32)17(2)24(31)27-10-12-35-13-11-27/h4-7,14-15,17,23H,3,8-13,16H2,1-2H3/t17-,23-/m0/s1 DSPUJUOXCWMCJY-SBUREZEXSA-N 12569 GTC000006A::N-(6-chloronaphthalen-2-yl)-N'-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-2-oxobutane-1-sulfonamido::pyrrolidin-2-one-based inhibitor 28 Coagulation factor X Homo sapiens 6.4 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12569&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10187006 46513027 ZINC14950166 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395720 C[C@H](N1CC[C@H](N(C)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C22H26ClN3O5S/c1-15(21(27)25-9-11-31-12-10-25)26-8-7-20(22(26)28)24(2)32(29,30)19-6-4-16-13-18(23)5-3-17(16)14-19/h3-6,13-15,20H,7-12H2,1-2H3/t15-,20-/m0/s1 XDIZICJZQYNVHW-YWZLYKJASA-N 12566 6-chloro-N-methyl-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide::GTC000007A::pyrrolidin-2-one-based inhibitor 25 Coagulation factor X Homo sapiens 70 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12566&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10227632 46513024 ZINC14950153 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395721 C[C@H](N1CC[C@H](N(CC#N)S(=O)(=O)c2ccc(s2)-c2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H23ClN4O5S3/c1-14(20(27)24-10-12-31-13-11-24)25-8-6-15(21(25)28)26(9-7-23)34(29,30)19-5-3-17(33-19)16-2-4-18(22)32-16/h2-5,14-15H,6,8-13H2,1H3/t14-,15-/m0/s1 MUNVXOMYOFIISN-GJZGRUSLSA-N 226020 GTC000008A Coagulation factor X Homo sapiens 28 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226020&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10187263 336293169 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395722 COC(=O)CN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)c1ccc(s1)-c1ccc(Cl)s1 InChI=1S/C22H26ClN3O7S3/c1-14(21(28)24-9-11-33-12-10-24)25-8-7-15(22(25)29)26(13-19(27)32-2)36(30,31)20-6-4-17(35-20)16-3-5-18(23)34-16/h3-6,14-15H,7-13H2,1-2H3/t14-,15-/m0/s1 ZDPIZMOGKZZWMV-GJZGRUSLSA-N 226021 GTC000009A Coagulation factor X Homo sapiens 15.5 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226021&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10120862 336293170 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395723 CCC(=O)CN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)c1ccc(s1)-c1ccc(Cl)s1 InChI=1S/C23H28ClN3O6S3/c1-3-16(28)14-27(36(31,32)21-7-5-19(35-21)18-4-6-20(24)34-18)17-8-9-26(23(17)30)15(2)22(29)25-10-12-33-13-11-25/h4-7,15,17H,3,8-14H2,1-2H3/t15-,17-/m0/s1 PIPROJVDCBAYFQ-RDJZCZTQSA-N 226022 GTC000010A Coagulation factor X Homo sapiens 17 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226022&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10281558 336293171 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395724 C[C@H](N1CC[C@H](N(CC#N)S(=O)(=O)\C=C\c2ccc(Cl)cc2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H25ClN4O5S/c1-16(20(27)24-11-13-31-14-12-24)25-9-6-19(21(25)28)26(10-8-23)32(29,30)15-7-17-2-4-18(22)5-3-17/h2-5,7,15-16,19H,6,9-14H2,1H3/b15-7+/t16-,19-/m0/s1 HYISNJUZKPKKCH-DXAXNQGJSA-N 226023 GTC000011A Coagulation factor X Homo sapiens 87.5 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226023&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10227693 336293172 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395725 CCC(=O)CN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)\C=C\c1ccc(Cl)cc1 InChI=1S/C23H30ClN3O6S/c1-3-20(28)16-27(34(31,32)15-9-18-4-6-19(24)7-5-18)21-8-10-26(23(21)30)17(2)22(29)25-11-13-33-14-12-25/h4-7,9,15,17,21H,3,8,10-14,16H2,1-2H3/b15-9+/t17-,21-/m0/s1 RMRQFOBKGJWUCD-TUAMIGAHSA-N 226024 GTC000012A Coagulation factor X Homo sapiens 60 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226024&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10164576 336293173 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395726 COC(=O)CN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)\C=C\c1ccc(Cl)cc1 InChI=1S/C22H28ClN3O7S/c1-16(21(28)24-10-12-33-13-11-24)25-9-7-19(22(25)29)26(15-20(27)32-2)34(30,31)14-8-17-3-5-18(23)6-4-17/h3-6,8,14,16,19H,7,9-13,15H2,1-2H3/b14-8+/t16-,19-/m0/s1 ZLGPXHQZLGUYEO-WTCBMFSRSA-N 226025 GTC000013A Coagulation factor X Homo sapiens 60 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226025&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10301325 336293174 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395727 C[C@H](N1CC[C@H](N(Cc2ccoc2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C26H28ClN3O6S/c1-18(25(31)28-9-12-35-13-10-28)29-8-6-24(26(29)32)30(16-19-7-11-36-17-19)37(33,34)23-5-3-20-14-22(27)4-2-21(20)15-23/h2-5,7,11,14-15,17-18,24H,6,8-10,12-13,16H2,1H3/t18-,24-/m0/s1 VSMYDIWQOVBDOR-UUOWRZLLSA-N 226026 GTC000014A Coagulation factor X Homo sapiens 40 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226026&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10143807 336293175 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395728 C[C@H](N1CC[C@H](N(Cc2cccnc2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C27H29ClN4O5S/c1-19(26(33)30-11-13-37-14-12-30)31-10-8-25(27(31)34)32(18-20-3-2-9-29-17-20)38(35,36)24-7-5-21-15-23(28)6-4-22(21)16-24/h2-7,9,15-17,19,25H,8,10-14,18H2,1H3/t19-,25-/m0/s1 CHKKYXSZHOMSPN-DFBJGRDBSA-N 226027 GTC000015A Coagulation factor X Homo sapiens 26.3 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226027&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10145450 336293176 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395729 C[C@H](N1CC[C@H](N(CC(O)=O)S(=O)(=O)c2ccc(s2)-c2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H24ClN3O7S3/c1-13(20(28)23-8-10-32-11-9-23)24-7-6-14(21(24)29)25(12-18(26)27)35(30,31)19-5-3-16(34-19)15-2-4-17(22)33-15/h2-5,13-14H,6-12H2,1H3,(H,26,27)/t13-,14-/m0/s1 DBZKQUOPWCRLAB-KBPBESRZSA-N 226028 GTC000016A Coagulation factor X Homo sapiens 24 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226028&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10231364 336293177 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395730 C[C@H](N1CC[C@H](N(CC(O)=O)S(=O)(=O)\C=C\c2ccc(Cl)cc2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H26ClN3O7S/c1-15(20(28)23-9-11-32-12-10-23)24-8-6-18(21(24)29)25(14-19(26)27)33(30,31)13-7-16-2-4-17(22)5-3-16/h2-5,7,13,15,18H,6,8-12,14H2,1H3,(H,26,27)/b13-7+/t15-,18-/m0/s1 BEUVFPREGFKXAD-KUJPFMKMSA-N 226029 GTC000017A Coagulation factor X Homo sapiens 132 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226029&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69065287 336293178 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395731 CCOC(=O)CN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)c1ccc2cc(Cl)ccc2c1 InChI=1S/C25H30ClN3O7S/c1-3-36-23(30)16-29(37(33,34)21-7-5-18-14-20(26)6-4-19(18)15-21)22-8-9-28(25(22)32)17(2)24(31)27-10-12-35-13-11-27/h4-7,14-15,17,22H,3,8-13,16H2,1-2H3/t17-,22-/m0/s1 PONWZVXIQQZYCB-JTSKRJEESA-N 226030 GTC000018A Coagulation factor X Homo sapiens 358 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226030&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69058775 336293179 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395732 C[C@H](N1CC[C@H](N(Cc2ccco2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C26H28ClN3O6S/c1-18(25(31)28-10-13-35-14-11-28)29-9-8-24(26(29)32)30(17-22-3-2-12-36-22)37(33,34)23-7-5-19-15-21(27)6-4-20(19)16-23/h2-7,12,15-16,18,24H,8-11,13-14,17H2,1H3/t18-,24-/m0/s1 PARXVTQEMHWTEM-UUOWRZLLSA-N 226031 GTC000019A Coagulation factor X Homo sapiens 68 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226031&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10280667 336293180 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395733 C[C@H](N1CC[C@H](N(Cc2nccs2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C25H27ClN4O5S2/c1-17(24(31)28-9-11-35-12-10-28)29-8-6-22(25(29)32)30(16-23-27-7-13-36-23)37(33,34)21-5-3-18-14-20(26)4-2-19(18)15-21/h2-5,7,13-15,17,22H,6,8-12,16H2,1H3/t17-,22-/m0/s1 DFFSXTOBBHWRCC-JTSKRJEESA-N 226032 GTC000020A Coagulation factor X Homo sapiens 38 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226032&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10281243 336293181 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395734 C[C@H](N1CC[C@H](N(CC(=O)C(C)(C)C)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C27H34ClN3O6S/c1-18(25(33)29-11-13-37-14-12-29)30-10-9-23(26(30)34)31(17-24(32)27(2,3)4)38(35,36)22-8-6-19-15-21(28)7-5-20(19)16-22/h5-8,15-16,18,23H,9-14,17H2,1-4H3/t18-,23-/m0/s1 VNTZDWUDGLAWMO-MBSDFSHPSA-N 226033 GTC000021A Coagulation factor X Homo sapiens 17 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226033&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10166612 336293182 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395735 C[C@H](N1CC[C@H](N(CC(=O)OC(C)(C)C)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C27H34ClN3O7S/c1-18(25(33)29-11-13-37-14-12-29)30-10-9-23(26(30)34)31(17-24(32)38-27(2,3)4)39(35,36)22-8-6-19-15-21(28)7-5-20(19)16-22/h5-8,15-16,18,23H,9-14,17H2,1-4H3/t18-,23-/m0/s1 KQMIJWATTZPQDL-MBSDFSHPSA-N 226034 GTC000022A Coagulation factor X Homo sapiens 6.5 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226034&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10210348 336293183 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395736 CCN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)c1ccc2cc(Cl)ccc2c1 InChI=1S/C23H28ClN3O5S/c1-3-27(33(30,31)20-7-5-17-14-19(24)6-4-18(17)15-20)21-8-9-26(23(21)29)16(2)22(28)25-10-12-32-13-11-25/h4-7,14-16,21H,3,8-13H2,1-2H3/t16-,21-/m0/s1 PMOIZZGKNUQBMU-KKSFZXQISA-N 226035 GTC000023A Coagulation factor X Homo sapiens 54 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226035&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10141411 336293184 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395737 C[C@H](N1CC[C@H](N(Cc2csc(C)n2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C26H29ClN4O5S2/c1-17(25(32)29-9-11-36-12-10-29)30-8-7-24(26(30)33)31(15-22-16-37-18(2)28-22)38(34,35)23-6-4-19-13-21(27)5-3-20(19)14-23/h3-6,13-14,16-17,24H,7-12,15H2,1-2H3/t17-,24-/m0/s1 VSRYPGRZIMXDAS-XDHUDOTRSA-N 226036 GTC000024A Coagulation factor X Homo sapiens 17.5 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226036&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10120893 336293185 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395738 CCC(=O)CN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)c1cc2ccc(Cl)cc2s1 InChI=1S/C23H28ClN3O6S2/c1-3-18(28)14-27(35(31,32)21-12-16-4-5-17(24)13-20(16)34-21)19-6-7-26(23(19)30)15(2)22(29)25-8-10-33-11-9-25/h4-5,12-13,15,19H,3,6-11,14H2,1-2H3/t15-,19-/m0/s1 TXRABPKRCFCBFV-KXBFYZLASA-N 226037 GTC000025A Coagulation factor X Homo sapiens 27 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226037&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10143669 336293186 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395739 C[C@H](N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2cc3ccc(Cl)cc3s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H25ClN4O6S2/c1-13(20(28)24-6-8-32-9-7-24)25-5-4-16(21(25)29)26(12-18(23)27)34(30,31)19-10-14-2-3-15(22)11-17(14)33-19/h2-3,10-11,13,16H,4-9,12H2,1H3,(H2,23,27)/t13-,16-/m0/s1 MGXYMQASXHYJAG-BBRMVZONSA-N 226038 GTC000026A Coagulation factor X Homo sapiens 50 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226038&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10301966 336293187 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395740 CCC(=O)CN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)c1cc2cc(Cl)ccc2s1 InChI=1S/C23H28ClN3O6S2/c1-3-18(28)14-27(35(31,32)21-13-16-12-17(24)4-5-20(16)34-21)19-6-7-26(23(19)30)15(2)22(29)25-8-10-33-11-9-25/h4-5,12-13,15,19H,3,6-11,14H2,1-2H3/t15-,19-/m0/s1 JTWGGGJPQNNLAK-KXBFYZLASA-N 226039 GTC000027A Coagulation factor X Homo sapiens 278 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226039&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69058926 336293188 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395741 C[C@H](N1CC[C@H](N(Cc2ccccn2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C27H29ClN4O5S/c1-19(26(33)30-12-14-37-15-13-30)31-11-9-25(27(31)34)32(18-23-4-2-3-10-29-23)38(35,36)24-8-6-20-16-22(28)7-5-21(20)17-24/h2-8,10,16-17,19,25H,9,11-15,18H2,1H3/t19-,25-/m0/s1 FCEIHHPCMZKNFX-DFBJGRDBSA-N 226040 GTC000028A Coagulation factor X Homo sapiens 8 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226040&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10232465 336293189 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395742 C[C@H](N1CC[C@H](N(Cc2ccccn2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C27H29ClN4O5S/c1-19(26(33)30-12-14-37-15-13-30)31-11-9-25(27(31)34)32(18-23-4-2-3-10-29-23)38(35,36)24-8-6-20-16-22(28)7-5-21(20)17-24/h2-8,10,16-17,19,25H,9,11-15,18H2,1H3/t19-,25-/m0/s1 FCEIHHPCMZKNFX-DFBJGRDBSA-N 226040 GTC000028A Coagulation factor X Homo sapiens 12 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226040&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10232465 336293189 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395743 C[C@H](N1CC[C@H](N(Cc2ccncc2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C27H29ClN4O5S/c1-19(26(33)30-12-14-37-15-13-30)31-11-8-25(27(31)34)32(18-20-6-9-29-10-7-20)38(35,36)24-5-3-21-16-23(28)4-2-22(21)17-24/h2-7,9-10,16-17,19,25H,8,11-15,18H2,1H3/t19-,25-/m0/s1 JNSWCLGWCZKKEQ-DFBJGRDBSA-N 226042 GTC000029A Coagulation factor X Homo sapiens 11 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226042&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10232467 336293190 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395744 C[C@H](N1CC[C@H](N(CC(N)=O)S(=O)(=O)\C=C\c2ccc(Cl)cc2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H27ClN4O6S/c1-15(20(28)24-9-11-32-12-10-24)25-8-6-18(21(25)29)26(14-19(23)27)33(30,31)13-7-16-2-4-17(22)5-3-16/h2-5,7,13,15,18H,6,8-12,14H2,1H3,(H2,23,27)/b13-7+/t15-,18-/m0/s1 UKXUKYYQADFHCP-KUJPFMKMSA-N 226043 GTC000030A Coagulation factor X Homo sapiens 54 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226043&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10141679 336293191 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395745 C[C@H](N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2cc3cc(Cl)ccc3s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H25ClN4O6S2/c1-13(20(28)24-6-8-32-9-7-24)25-5-4-16(21(25)29)26(12-18(23)27)34(30,31)19-11-14-10-15(22)2-3-17(14)33-19/h2-3,10-11,13,16H,4-9,12H2,1H3,(H2,23,27)/t13-,16-/m0/s1 CHIVOTZOQTVPRD-BBRMVZONSA-N 226044 GTC000031A Coagulation factor X Homo sapiens 218.5 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226044&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69058836 336293192 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395746 C[C@H](N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2ccc(s2)-c2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H25ClN4O6S3/c1-13(20(28)24-8-10-32-11-9-24)25-7-6-14(21(25)29)26(12-18(23)27)35(30,31)19-5-3-16(34-19)15-2-4-17(22)33-15/h2-5,13-14H,6-12H2,1H3,(H2,23,27)/t13-,14-/m0/s1 BATODKJFUYDJII-KBPBESRZSA-N 226045 GTC000032A Coagulation factor X Homo sapiens 14 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226045&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10281174 336293193 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395747 C[C@H](N1CC[C@H](N(c2ccccc2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C27H28ClN3O5S/c1-19(26(32)29-13-15-36-16-14-29)30-12-11-25(27(30)33)31(23-5-3-2-4-6-23)37(34,35)24-10-8-20-17-22(28)9-7-21(20)18-24/h2-10,17-19,25H,11-16H2,1H3/t19-,25-/m0/s1 CVFXMEABOJPJAW-DFBJGRDBSA-N 226046 GTC000033A Coagulation factor X Homo sapiens 266 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226046&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69058731 336293194 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395748 C[C@H](N1CC[C@H](N(c2ccc(F)cc2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C27H27ClFN3O5S/c1-18(26(33)30-12-14-37-15-13-30)31-11-10-25(27(31)34)32(23-7-5-22(29)6-8-23)38(35,36)24-9-3-19-16-21(28)4-2-20(19)17-24/h2-9,16-18,25H,10-15H2,1H3/t18-,25-/m0/s1 LYTDYGIGGFYQEM-BVZFJXPGSA-N 226047 GTC000034A Coagulation factor X Homo sapiens 170 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226047&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69058834 336293195 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395749 C[C@H](N1CC[C@H](N(c2ccsc2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C25H26ClN3O5S2/c1-17(24(30)27-9-11-34-12-10-27)28-8-6-23(25(28)31)29(21-7-13-35-16-21)36(32,33)22-5-3-18-14-20(26)4-2-19(18)15-22/h2-5,7,13-17,23H,6,8-12H2,1H3/t17-,23-/m0/s1 SFWBQQAQHBYNHA-SBUREZEXSA-N 226048 GTC000036A Coagulation factor X Homo sapiens 152 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226048&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69060484 336293196 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395750 C[C@H](N1CC[C@H](N(c2cccnc2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C26H27ClN4O5S/c1-18(25(32)29-11-13-36-14-12-29)30-10-8-24(26(30)33)31(22-3-2-9-28-17-22)37(34,35)23-7-5-19-15-21(27)6-4-20(19)16-23/h2-7,9,15-18,24H,8,10-14H2,1H3/t18-,24-/m0/s1 OYRQBJDKGWDSHV-UUOWRZLLSA-N 226049 GTC000037A Coagulation factor X Homo sapiens 77 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226049&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69058256 336293197 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395751 C[C@H](N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1C[C@H](C)O[C@H](C)C1 InChI=1S/C25H31ClN4O6S/c1-15-12-28(13-16(2)36-15)24(32)17(3)29-9-8-22(25(29)33)30(14-23(27)31)37(34,35)21-7-5-18-10-20(26)6-4-19(18)11-21/h4-7,10-11,15-17,22H,8-9,12-14H2,1-3H3,(H2,27,31)/t15-,16+,17-,22-/m0/s1 ZIASRVHJMRINIM-GEYWLOKFSA-N 226050 GTC000038A Coagulation factor X Homo sapiens 26.5 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226050&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10187544 336293198 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395752 C[C@H](N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1C[C@@H]2C[C@H]1CO2 InChI=1S/C24H27ClN4O6S/c1-14(23(31)28-11-19-10-18(28)13-35-19)27-7-6-21(24(27)32)29(12-22(26)30)36(33,34)20-5-3-15-8-17(25)4-2-16(15)9-20/h2-5,8-9,14,18-19,21H,6-7,10-13H2,1H3,(H2,26,30)/t14-,18-,19-,21-/m0/s1 PJGBTTGTFCVAKC-KKTRPPJXSA-N 226051 GTC000039A Coagulation factor X Homo sapiens 97.3 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226051&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69329177 336293199 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395753 C[C@H](N1CC[C@H](N(CCN2CCOCC2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C27H35ClN4O6S/c1-20(26(33)30-12-16-38-17-13-30)31-7-6-25(27(31)34)32(9-8-29-10-14-37-15-11-29)39(35,36)24-5-3-21-18-23(28)4-2-22(21)19-24/h2-5,18-20,25H,6-17H2,1H3/t20-,25-/m0/s1 VALMDQTVMWWSIP-CPJSRVTESA-N 226052 GTC000040A Coagulation factor X Homo sapiens 8.3 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226052&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10189366 336293200 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395754 C[C@H](N1CC[C@H](N(CCNC(C)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C25H31ClN4O6S/c1-17(24(32)28-11-13-36-14-12-28)29-9-7-23(25(29)33)30(10-8-27-18(2)31)37(34,35)22-6-4-19-15-21(26)5-3-20(19)16-22/h3-6,15-17,23H,7-14H2,1-2H3,(H,27,31)/t17-,23-/m0/s1 ARRMHVXQPQTJMS-SBUREZEXSA-N 226053 GTC000041A Coagulation factor X Homo sapiens 56.5 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226053&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10302798 336293201 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395755 C[C@H](N1CC[C@H](N(CCN(C)C)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C25H33ClN4O5S/c1-18(24(31)28-12-14-35-15-13-28)29-9-8-23(25(29)32)30(11-10-27(2)3)36(33,34)22-7-5-19-16-21(26)6-4-20(19)17-22/h4-7,16-18,23H,8-15H2,1-3H3/t18-,23-/m0/s1 JRFUZAKGBFMVEZ-MBSDFSHPSA-N 226054 GTC000042A Coagulation factor X Homo sapiens 24 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226054&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10303748 336293202 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395756 C[C@H](N1CC[C@H](N(CCN2CCCC2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C27H35ClN4O5S/c1-20(26(33)30-14-16-37-17-15-30)31-11-8-25(27(31)34)32(13-12-29-9-2-3-10-29)38(35,36)24-7-5-21-18-23(28)6-4-22(21)19-24/h4-7,18-20,25H,2-3,8-17H2,1H3/t20-,25-/m0/s1 XCZGJWODJAVKAT-CPJSRVTESA-N 226055 GTC000043A Coagulation factor X Homo sapiens 12 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226055&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10304331 336293203 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395757 C[C@H](N1CC[C@H](N(C)S(=O)(=O)\C=C\c2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C18H24ClN3O5S2/c1-13(17(23)21-8-10-27-11-9-21)22-7-5-15(18(22)24)20(2)29(25,26)12-6-14-3-4-16(19)28-14/h3-4,6,12-13,15H,5,7-11H2,1-2H3/b12-6+/t13-,15-/m0/s1 KTWAMXPFGPDANL-XZSJCOBXSA-N 226056 GTC000044A Coagulation factor X Homo sapiens 405 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226056&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69059144 336293204 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395758 Fc1cc(ccc1N1CC[C@H](NS(=O)(=O)\C=C\c2ccc(Cl)s2)C1=O)C(=O)N1CCCC1 InChI=1S/C21H21ClFN3O4S2/c22-19-6-4-15(31-19)8-12-32(29,30)24-17-7-11-26(21(17)28)18-5-3-14(13-16(18)23)20(27)25-9-1-2-10-25/h3-6,8,12-13,17,24H,1-2,7,9-11H2/b12-8+/t17-/m0/s1 IDBAAQURQASERV-UEICXMAYSA-N 226057 GTC000098A Coagulation factor X Homo sapiens 603.5 D3R 10.7270/Q2GM865X aid1802760 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226057&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69753482 336293205 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395759 C[C@H](N1CC[C@H](N(CC(O)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C23H26ClN3O7S/c1-15(22(30)25-8-10-34-11-9-25)26-7-6-20(23(26)31)27(14-21(28)29)35(32,33)19-5-3-16-12-18(24)4-2-17(16)13-19/h2-5,12-13,15,20H,6-11,14H2,1H3,(H,28,29)/t15-,20-/m0/s1 UAYCGHBBLVJXTC-YWZLYKJASA-N 12567 2-[(6-chloronaphthalene-2-)[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]sulfonamido]acetic acid::GTC000002A::pyrrolidin-2-one-based inhibitor 26 Coagulation factor X Homo sapiens 4.36 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12567&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10142920 46513025 ZINC14950158 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395760 C[C@H](N1CC[C@H](N(CC#N)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C23H25ClN4O5S/c1-16(22(29)26-10-12-33-13-11-26)27-8-6-21(23(27)30)28(9-7-25)34(31,32)20-5-3-17-14-19(24)4-2-18(17)15-20/h2-5,14-16,21H,6,8-13H2,1H3/t16-,21-/m0/s1 MMFJBPKSIQNYKR-KKSFZXQISA-N 226018 GTC000003A Coagulation factor X Homo sapiens 6.53 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226018&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10278908 336293167 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395761 C[C@H](N1CC[C@H](N(CC(N)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C23H27ClN4O6S/c1-15(22(30)26-8-10-34-11-9-26)27-7-6-20(23(27)31)28(14-21(25)29)35(32,33)19-5-3-16-12-18(24)4-2-17(16)13-19/h2-5,12-13,15,20H,6-11,14H2,1H3,(H2,25,29)/t15-,20-/m0/s1 DRTYVXQQGDRUEW-YWZLYKJASA-N 12568 2-[(6-chloronaphthalene-2-)[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]sulfonamido]acetamide::GTC000005A::pyrrolidin-2-one-based inhibitor 27 Coagulation factor X Homo sapiens 4.41 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12568&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10301730 46513026 ZINC14950162 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395762 CCC(=O)CN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)c1ccc2cc(Cl)ccc2c1 InChI=1S/C25H30ClN3O6S/c1-3-21(30)16-29(36(33,34)22-7-5-18-14-20(26)6-4-19(18)15-22)23-8-9-28(25(23)32)17(2)24(31)27-10-12-35-13-11-27/h4-7,14-15,17,23H,3,8-13,16H2,1-2H3/t17-,23-/m0/s1 DSPUJUOXCWMCJY-SBUREZEXSA-N 12569 GTC000006A::N-(6-chloronaphthalen-2-yl)-N'-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxopropan-2-yl]-2-oxopyrrolidin-3-yl]-2-oxobutane-1-sulfonamido::pyrrolidin-2-one-based inhibitor 28 Coagulation factor X Homo sapiens 1.11 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12569&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10187006 46513027 ZINC14950166 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395763 C[C@H](N1CC[C@H](N(CC(O)=O)S(=O)(=O)c2ccc(s2)-c2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H24ClN3O7S3/c1-13(20(28)23-8-10-32-11-9-23)24-7-6-14(21(24)29)25(12-18(26)27)35(30,31)19-5-3-16(34-19)15-2-4-17(22)33-15/h2-5,13-14H,6-12H2,1H3,(H,26,27)/t13-,14-/m0/s1 DBZKQUOPWCRLAB-KBPBESRZSA-N 226028 GTC000016A Coagulation factor X Homo sapiens 3.89 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226028&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10231364 336293177 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395764 C[C@H](N1CC[C@H](N(CC(O)=O)S(=O)(=O)\C=C\c2ccc(Cl)cc2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H26ClN3O7S/c1-15(20(28)23-9-11-32-12-10-23)24-8-6-18(21(24)29)25(14-19(26)27)33(30,31)13-7-16-2-4-17(22)5-3-16/h2-5,7,13,15,18H,6,8-12,14H2,1H3,(H,26,27)/b13-7+/t15-,18-/m0/s1 BEUVFPREGFKXAD-KUJPFMKMSA-N 226029 GTC000017A Coagulation factor X Homo sapiens 19.45 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226029&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69065287 336293178 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395765 C[C@H](N1CC[C@H](N(c2cccnc2)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O)C(=O)N1CCOCC1 InChI=1S/C26H27ClN4O5S/c1-18(25(32)29-11-13-36-14-12-29)30-10-8-24(26(30)33)31(22-3-2-9-28-17-22)37(34,35)23-7-5-19-15-21(27)6-4-20(19)16-23/h2-7,9,15-18,24H,8,10-14H2,1H3/t18-,24-/m0/s1 OYRQBJDKGWDSHV-UUOWRZLLSA-N 226049 GTC000037A Coagulation factor X Homo sapiens 141 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226049&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69058256 336293197 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395766 C[C@H](N1CC[C@H](N(C)S(=O)(=O)\C=C\c2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C18H24ClN3O5S2/c1-13(17(23)21-8-10-27-11-9-21)22-7-5-15(18(22)24)20(2)29(25,26)12-6-14-3-4-16(19)28-14/h3-4,6,12-13,15H,5,7-11H2,1-2H3/b12-6+/t13-,15-/m0/s1 KTWAMXPFGPDANL-XZSJCOBXSA-N 226056 GTC000044A Coagulation factor X Homo sapiens 44.7 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226056&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69059144 336293204 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395767 C[C@H](N1CC[C@H](N(C)S(=O)(=O)CCc2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C18H26ClN3O5S2/c1-13(17(23)21-8-10-27-11-9-21)22-7-5-15(18(22)24)20(2)29(25,26)12-6-14-3-4-16(19)28-14/h3-4,13,15H,5-12H2,1-2H3/t13-,15-/m0/s1 MYJHFLFZMIRTBU-ZFWWWQNUSA-N 226058 GTC000045A Coagulation factor X Homo sapiens 95.13 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226058&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58677369 336293206 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395768 COC(=O)CN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)CCc1ccc(Cl)s1 InChI=1S/C20H28ClN3O7S2/c1-14(19(26)22-8-10-31-11-9-22)23-7-5-16(20(23)27)24(13-18(25)30-2)33(28,29)12-6-15-3-4-17(21)32-15/h3-4,14,16H,5-13H2,1-2H3/t14-,16-/m0/s1 VZLKLLTZQDSWNH-HOCLYGCPSA-N 226059 GTC000046A Coagulation factor X Homo sapiens 12.82 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226059&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58677358 336293207 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395769 CCOC(=O)CN([C@H]1CCN([C@@H](C)C(=O)N2CCOCC2)C1=O)S(=O)(=O)CCc1ccc(Cl)s1 InChI=1S/C21H30ClN3O7S2/c1-3-32-19(26)14-25(34(29,30)13-7-16-4-5-18(22)33-16)17-6-8-24(21(17)28)15(2)20(27)23-9-11-31-12-10-23/h4-5,15,17H,3,6-14H2,1-2H3/t15-,17-/m0/s1 AZDDQBSUJAAFJC-RDJZCZTQSA-N 226060 GTC000047A Coagulation factor X Homo sapiens 9.67 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226060&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10482285 336293208 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395770 CC[C@H](C)[C@H](N1CC[C@H](N(CC(=O)N(C)C)S(=O)(=O)CCc2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C24H37ClN4O6S2/c1-5-17(2)22(24(32)27-11-13-35-14-12-27)28-10-8-19(23(28)31)29(16-21(30)26(3)4)37(33,34)15-9-18-6-7-20(25)36-18/h6-7,17,19,22H,5,8-16H2,1-4H3/t17-,19-,22-/m0/s1 QETDMHQUQVQNJG-JLMWRMLUSA-N 226061 GTC000048A Coagulation factor X Homo sapiens 4381 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226061&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69153548 336293209 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395771 CC[C@H](C)[C@H](N1CC[C@H](N(CC(=O)NC)S(=O)(=O)CCc2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C23H35ClN4O6S2/c1-4-16(2)21(23(31)26-10-12-34-13-11-26)27-9-7-18(22(27)30)28(15-20(29)25-3)36(32,33)14-8-17-5-6-19(24)35-17/h5-6,16,18,21H,4,7-15H2,1-3H3,(H,25,29)/t16-,18-,21-/m0/s1 VGLPAMQJSGWZFO-MDKPJZGXSA-N 226062 GTC000049A Coagulation factor X Homo sapiens 6669 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226062&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58677327 336293210 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395772 CC[C@H](C)[C@H](N1CC[C@H](N(C)S(=O)(=O)CCc2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C21H32ClN3O5S2/c1-4-15(2)19(21(27)24-10-12-30-13-11-24)25-9-7-17(20(25)26)23(3)32(28,29)14-8-16-5-6-18(22)31-16/h5-6,15,17,19H,4,7-14H2,1-3H3/t15-,17-,19-/m0/s1 QADVUXMZILRWOD-IEZWGBDMSA-N 226063 GTC000050A Coagulation factor X Homo sapiens 5939 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226063&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58677241 336293211 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395773 COC[C@H](N1CC[C@H](N(CC(=O)N(C)C)S(=O)(=O)CCc2ccc(Cl)s2)C1=O)C(=O)N1CCOCC1 InChI=1S/C22H33ClN4O7S2/c1-24(2)20(28)14-27(36(31,32)13-7-16-4-5-19(23)35-16)17-6-8-26(22(17)30)18(15-33-3)21(29)25-9-11-34-12-10-25/h4-5,17-18H,6-15H2,1-3H3/t17-,18-/m0/s1 IBHFLYRZWBZBEI-ROUUACIJSA-N 226064 GTC000051A Coagulation factor X Homo sapiens 2090 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226064&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58677323 336293212 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395774 CN([C@H]1CCN([C@@H](Cc2nc(C)no2)C(=O)N2CCOCC2)C1=O)S(=O)(=O)CCc1ccc(Cl)s1 InChI=1S/C21H28ClN5O6S2/c1-14-23-19(33-24-14)13-17(20(28)26-8-10-32-11-9-26)27-7-5-16(21(27)29)25(2)35(30,31)12-6-15-3-4-18(22)34-15/h3-4,16-17H,5-13H2,1-2H3/t16-,17-/m0/s1 CATFQQCSNRBCLE-IRXDYDNUSA-N 226065 GTC000052A Coagulation factor X Homo sapiens 21673 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226065&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 58677335 336293213 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395775 CN(C)C(=O)c1ccc(N2CC[C@H](N(C)S(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C20H21ClFN3O4S2/c1-23(2)19(26)13-4-6-16(15(22)12-13)25-10-8-17(20(25)27)24(3)31(28,29)11-9-14-5-7-18(21)30-14/h4-7,9,11-12,17H,8,10H2,1-3H3/b11-9+/t17-/m0/s1 UFUJISJRGTVNEN-KAMXEHQASA-N 226066 GTC000053A Coagulation factor X Homo sapiens 14.4 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226066&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11397603 336293214 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395776 CN(CCc1ccccc1)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C26H25ClFN3O4S2/c1-30(14-11-18-5-3-2-4-6-18)25(32)19-7-9-23(21(28)17-19)31-15-12-22(26(31)33)29-37(34,35)16-13-20-8-10-24(27)36-20/h2-10,13,16-17,22,29H,11-12,14-15H2,1H3/b16-13+/t22-/m0/s1 HGUSNGVGMMJBHJ-ANCZKMTESA-N 226067 GTC000054A Coagulation factor X Homo sapiens 248 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226067&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962484 336293215 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395777 CN(CCc1cccnc1)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C25H24ClFN4O4S2/c1-30(12-8-17-3-2-11-28-16-17)24(32)18-4-6-22(20(27)15-18)31-13-9-21(25(31)33)29-37(34,35)14-10-19-5-7-23(26)36-19/h2-7,10-11,14-16,21,29H,8-9,12-13H2,1H3/b14-10+/t21-/m0/s1 XYHVTOCZTWSOSD-OQHXPNFOSA-N 226068 GTC000055A Coagulation factor X Homo sapiens 29.9 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226068&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962485 336293216 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395778 Fc1cc(ccc1N1CC[C@H](NS(=O)(=O)\C=C\c2ccc(Cl)s2)C1=O)C(=O)NCc1ccncc1 InChI=1S/C23H20ClFN4O4S2/c24-21-4-2-17(34-21)8-12-35(32,33)28-19-7-11-29(23(19)31)20-3-1-16(13-18(20)25)22(30)27-14-15-5-9-26-10-6-15/h1-6,8-10,12-13,19,28H,7,11,14H2,(H,27,30)/b12-8+/t19-/m0/s1 SQYWVOHXIIJDBT-BEBFYNPSSA-N 226069 GTC000056A Coagulation factor X Homo sapiens 563 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226069&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962486 336293217 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395779 Fc1cc(ccc1N1CC[C@H](NS(=O)(=O)\C=C\c2ccc(Cl)s2)C1=O)C(=O)NCc1cccnc1 InChI=1S/C23H20ClFN4O4S2/c24-21-6-4-17(34-21)8-11-35(32,33)28-19-7-10-29(23(19)31)20-5-3-16(12-18(20)25)22(30)27-14-15-2-1-9-26-13-15/h1-6,8-9,11-13,19,28H,7,10,14H2,(H,27,30)/b11-8+/t19-/m0/s1 JTYGFPDTYACYDP-BLRBJFNZSA-N 226070 GTC000057A Coagulation factor X Homo sapiens 1540 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226070&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962487 336293218 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395780 CN(CCO)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C20H21ClFN3O5S2/c1-24(9-10-26)19(27)13-2-4-17(15(22)12-13)25-8-6-16(20(25)28)23-32(29,30)11-7-14-3-5-18(21)31-14/h2-5,7,11-12,16,23,26H,6,8-10H2,1H3/b11-7+/t16-/m0/s1 MGTMGJTXHUYKPT-BPLPYTOXSA-N 226071 GTC000058A Coagulation factor X Homo sapiens 375 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226071&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962488 336293219 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395781 Fc1cc(ccc1N1CC[C@H](NS(=O)(=O)\C=C\c2ccc(Cl)s2)C1=O)C(=O)NCc1ccccc1 InChI=1S/C24H21ClFN3O4S2/c25-22-9-7-18(34-22)11-13-35(32,33)28-20-10-12-29(24(20)31)21-8-6-17(14-19(21)26)23(30)27-15-16-4-2-1-3-5-16/h1-9,11,13-14,20,28H,10,12,15H2,(H,27,30)/b13-11+/t20-/m0/s1 CJOPFGBYOPXYEO-RPAADVPWSA-N 226072 GTC000059A Coagulation factor X Homo sapiens 4393 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226072&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962489 336293220 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395782 COCCN(C)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C21H23ClFN3O5S2/c1-25(10-11-31-2)20(27)14-3-5-18(16(23)13-14)26-9-7-17(21(26)28)24-33(29,30)12-8-15-4-6-19(22)32-15/h3-6,8,12-13,17,24H,7,9-11H2,1-2H3/b12-8+/t17-/m0/s1 CWWGDYDNRHEIMX-UEICXMAYSA-N 226073 GTC000060A Coagulation factor X Homo sapiens 798 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226073&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962490 336293221 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395783 CN(C)CCN(C)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C22H26ClFN4O4S2/c1-26(2)11-12-27(3)21(29)15-4-6-19(17(24)14-15)28-10-8-18(22(28)30)25-34(31,32)13-9-16-5-7-20(23)33-16/h4-7,9,13-14,18,25H,8,10-12H2,1-3H3/b13-9+/t18-/m0/s1 QNYRRKFWXWOLOT-FUNAXGEOSA-N 226074 GTC000061A Coagulation factor X Homo sapiens 399 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226074&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962491 336293222 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395784 CN(CCS(C)(=O)=O)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C21H23ClFN3O6S3/c1-25(10-12-34(2,29)30)20(27)14-3-5-18(16(23)13-14)26-9-7-17(21(26)28)24-35(31,32)11-8-15-4-6-19(22)33-15/h3-6,8,11,13,17,24H,7,9-10,12H2,1-2H3/b11-8+/t17-/m0/s1 QURYCNVSNLCSAB-YRYLYKBFSA-N 226075 GTC000062A Coagulation factor X Homo sapiens 1075 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226075&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962492 336293223 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395785 CN(CC=C)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C21H21ClFN3O4S2/c1-3-10-25(2)20(27)14-4-6-18(16(23)13-14)26-11-8-17(21(26)28)24-32(29,30)12-9-15-5-7-19(22)31-15/h3-7,9,12-13,17,24H,1,8,10-11H2,2H3/b12-9+/t17-/m0/s1 PKEABSGNCCITEN-KQPPXVQYSA-N 226076 GTC000063A Coagulation factor X Homo sapiens 137 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226076&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962493 336293224 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395786 CN(CC(N)=O)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C20H20ClFN4O5S2/c1-25(11-18(23)27)19(28)12-2-4-16(14(22)10-12)26-8-6-15(20(26)29)24-33(30,31)9-7-13-3-5-17(21)32-13/h2-5,7,9-10,15,24H,6,8,11H2,1H3,(H2,23,27)/b9-7+/t15-/m0/s1 VUYAMTBLJZPZGK-HEWZJLJBSA-N 226077 GTC000064A Coagulation factor X Homo sapiens 1194 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226077&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962494 336293225 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395787 CN(Cc1ccncc1)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C24H22ClFN4O4S2/c1-29(15-16-6-10-27-11-7-16)23(31)17-2-4-21(19(26)14-17)30-12-8-20(24(30)32)28-36(33,34)13-9-18-3-5-22(25)35-18/h2-7,9-11,13-14,20,28H,8,12,15H2,1H3/b13-9+/t20-/m0/s1 WZCNMKWOHHUOET-SQSZOCELSA-N 226078 GTC000065A Coagulation factor X Homo sapiens 1487 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226078&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962495 336293226 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395788 CN(CCN1CCCC1)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C24H28ClFN4O4S2/c1-28(13-14-29-10-2-3-11-29)23(31)17-4-6-21(19(26)16-17)30-12-8-20(24(30)32)27-36(33,34)15-9-18-5-7-22(25)35-18/h4-7,9,15-16,20,27H,2-3,8,10-14H2,1H3/b15-9+/t20-/m0/s1 QSAWNXNIGZJMAQ-ULXKQSRTSA-N 226079 GTC000066A Coagulation factor X Homo sapiens 285.5 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226079&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962496 336293227 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395789 CN(CCc1c[nH]cn1)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C23H23ClFN5O4S2/c1-29(9-6-16-13-26-14-27-16)22(31)15-2-4-20(18(25)12-15)30-10-7-19(23(30)32)28-36(33,34)11-8-17-3-5-21(24)35-17/h2-5,8,11-14,19,28H,6-7,9-10H2,1H3,(H,26,27)/b11-8+/t19-/m0/s1 NJEOFPIBRORNLV-BLRBJFNZSA-N 226080 GTC000067A Coagulation factor X Homo sapiens 603 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226080&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962497 336293228 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395790 CN(CCCO)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C21H23ClFN3O5S2/c1-25(9-2-11-27)20(28)14-3-5-18(16(23)13-14)26-10-7-17(21(26)29)24-33(30,31)12-8-15-4-6-19(22)32-15/h3-6,8,12-13,17,24,27H,2,7,9-11H2,1H3/b12-8+/t17-/m0/s1 JOUZKKYHDUHWMR-UEICXMAYSA-N 226081 GTC000068A Coagulation factor X Homo sapiens 510 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226081&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962498 336293229 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395791 CNC(=O)CCN(C)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C22H24ClFN4O5S2/c1-25-20(29)8-10-27(2)21(30)14-3-5-18(16(24)13-14)28-11-7-17(22(28)31)26-35(32,33)12-9-15-4-6-19(23)34-15/h3-6,9,12-13,17,26H,7-8,10-11H2,1-2H3,(H,25,29)/b12-9+/t17-/m0/s1 LNOJUFJDZLXTFC-KQPPXVQYSA-N 226082 GTC000069A Coagulation factor X Homo sapiens 845 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226082&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962499 336293230 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395792 CN(CCc1nc[nH]c1C)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C24H25ClFN5O4S2/c1-15-19(28-14-27-15)7-10-30(2)23(32)16-3-5-21(18(26)13-16)31-11-8-20(24(31)33)29-37(34,35)12-9-17-4-6-22(25)36-17/h3-6,9,12-14,20,29H,7-8,10-11H2,1-2H3,(H,27,28)/b12-9+/t20-/m0/s1 RJTVQXDFOITLQN-JTPHSUOKSA-N 226083 GTC000070A Coagulation factor X Homo sapiens 677 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226083&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962500 336293231 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395793 CN(CC(O)=O)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C20H19ClFN3O6S2/c1-24(11-18(26)27)19(28)12-2-4-16(14(22)10-12)25-8-6-15(20(25)29)23-33(30,31)9-7-13-3-5-17(21)32-13/h2-5,7,9-10,15,23H,6,8,11H2,1H3,(H,26,27)/b9-7+/t15-/m0/s1 BVGRZVOIVWOQNU-HEWZJLJBSA-N 226084 GTC000071A Coagulation factor X Homo sapiens 562 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226084&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962501 336293232 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395794 OC(=O)CNC(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C19H17ClFN3O6S2/c20-16-4-2-12(31-16)6-8-32(29,30)23-14-5-7-24(19(14)28)15-3-1-11(9-13(15)21)18(27)22-10-17(25)26/h1-4,6,8-9,14,23H,5,7,10H2,(H,22,27)(H,25,26)/b8-6+/t14-/m0/s1 HCWJXHSABJZFHP-OWNNVSBGSA-N 226085 GTC000072A Coagulation factor X Homo sapiens 4172 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226085&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962502 336293233 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395795 CN(CCO)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C21H23ClFN3O5S2/c1-13(18-5-6-19(22)32-18)12-33(30,31)24-16-7-8-26(21(16)29)17-4-3-14(11-15(17)23)20(28)25(2)9-10-27/h3-6,11-12,16,24,27H,7-10H2,1-2H3/b13-12+/t16-/m0/s1 YEFAPIGVQXFLDJ-DBTPVHCXSA-N 226086 GTC000073A Coagulation factor X Homo sapiens 275 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226086&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962503 336293234 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395796 CN(Cc1ccccn1)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C25H24ClFN4O4S2/c1-16(22-8-9-23(26)36-22)15-37(34,35)29-20-10-12-31(25(20)33)21-7-6-17(13-19(21)27)24(32)30(2)14-18-5-3-4-11-28-18/h3-9,11,13,15,20,29H,10,12,14H2,1-2H3/b16-15+/t20-/m0/s1 UOVNSLHKFFYVDH-APHAIJBRSA-N 226087 GTC000074A Coagulation factor X Homo sapiens 131 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226087&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962504 336293235 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395797 CNCCN(C)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C22H26ClFN4O4S2/c1-14(19-6-7-20(23)33-19)13-34(31,32)26-17-8-10-28(22(17)30)18-5-4-15(12-16(18)24)21(29)27(3)11-9-25-2/h4-7,12-13,17,25-26H,8-11H2,1-3H3/b14-13+/t17-/m0/s1 DJLSNGFTRGLGDO-CLVCIHKQSA-N 226088 GTC000075A Coagulation factor X Homo sapiens 4.41 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226088&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962505 336293236 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395798 CN(CCS(C)(=O)=O)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C22H25ClFN3O6S3/c1-14(19-6-7-20(23)34-19)13-36(32,33)25-17-8-9-27(22(17)29)18-5-4-15(12-16(18)24)21(28)26(2)10-11-35(3,30)31/h4-7,12-13,17,25H,8-11H2,1-3H3/b14-13+/t17-/m0/s1 FNEDWSNGTJAKSZ-CLVCIHKQSA-N 226089 GTC000076A Coagulation factor X Homo sapiens 38.6 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226089&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962506 336293237 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395799 COCCN(C)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C22H25ClFN3O5S2/c1-14(19-6-7-20(23)33-19)13-34(30,31)25-17-8-9-27(22(17)29)18-5-4-15(12-16(18)24)21(28)26(2)10-11-32-3/h4-7,12-13,17,25H,8-11H2,1-3H3/b14-13+/t17-/m0/s1 IXBDHWHQAJDEAU-CLVCIHKQSA-N 226090 GTC000077A Coagulation factor X Homo sapiens 180 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226090&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962507 336293238 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395800 CN(C)C(=O)c1ccc(N2CC[C@H](N(C)S(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C21H23ClFN3O4S2/c1-13(18-7-8-19(22)31-18)12-32(29,30)25(4)17-9-10-26(21(17)28)16-6-5-14(11-15(16)23)20(27)24(2)3/h5-8,11-12,17H,9-10H2,1-4H3/b13-12+/t17-/m0/s1 IUOXBBNPMZHGCV-UJGDBWEASA-N 226091 GTC000078A Coagulation factor X Homo sapiens 1.24 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226091&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11214193 336293239 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395801 CN(C)CCN(C)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)c3cc4ccc(Cl)cc4s3)C2=O)c(F)c1 InChI=1S/C24H26ClFN4O4S2/c1-28(2)10-11-29(3)23(31)16-5-7-20(18(26)12-16)30-9-8-19(24(30)32)27-36(33,34)22-13-15-4-6-17(25)14-21(15)35-22/h4-7,12-14,19,27H,8-11H2,1-3H3/t19-/m0/s1 VBEQUNMFVWEVAQ-IBGZPJMESA-N 226092 GTC000079A Coagulation factor X Homo sapiens 414 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226092&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962508 336293240 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395802 CNCCN(C)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)c3cc4ccc(Cl)cc4s3)C2=O)c(F)c1 InChI=1S/C23H24ClFN4O4S2/c1-26-8-10-28(2)22(30)15-4-6-19(17(25)11-15)29-9-7-18(23(29)31)27-35(32,33)21-12-14-3-5-16(24)13-20(14)34-21/h3-6,11-13,18,26-27H,7-10H2,1-2H3/t18-/m0/s1 VSAPUMBGKXDGNR-SFHVURJKSA-N 226093 GTC000080A Coagulation factor X Homo sapiens 15.9 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226093&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962509 336293241 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395803 CN(CCN)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)c3cc4ccc(Cl)cc4s3)C2=O)c(F)c1 InChI=1S/C22H22ClFN4O4S2/c1-27(9-7-25)21(29)14-3-5-18(16(24)10-14)28-8-6-17(22(28)30)26-34(31,32)20-11-13-2-4-15(23)12-19(13)33-20/h2-5,10-12,17,26H,6-9,25H2,1H3/t17-/m0/s1 ZSABRQVWRZBFJQ-KRWDZBQOSA-N 226094 GTC000081A Coagulation factor X Homo sapiens 258 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226094&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962510 336293242 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395804 CN(CCc1cccnc1)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)c3cc4ccc(Cl)cc4s3)C2=O)c(F)c1 InChI=1S/C27H24ClFN4O4S2/c1-32(11-8-17-3-2-10-30-16-17)26(34)19-5-7-23(21(29)13-19)33-12-9-22(27(33)35)31-39(36,37)25-14-18-4-6-20(28)15-24(18)38-25/h2-7,10,13-16,22,31H,8-9,11-12H2,1H3/t22-/m0/s1 FNLXHTCIXFWNNP-QFIPXVFZSA-N 226095 GTC000082A Coagulation factor X Homo sapiens 91.5 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226095&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962511 336293243 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395805 CN(C)CCN(C)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C23H28ClFN4O4S2/c1-15(20-7-8-21(24)34-20)14-35(32,33)26-18-9-10-29(23(18)31)19-6-5-16(13-17(19)25)22(30)28(4)12-11-27(2)3/h5-8,13-14,18,26H,9-12H2,1-4H3/b15-14+/t18-/m0/s1 TZJZLNSDMWMHLM-JJJPLKNQSA-N 226096 GTC000083A Coagulation factor X Homo sapiens 35.5 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226096&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962512 336293244 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395806 CN(CCc1cccnc1)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C26H26ClFN4O4S2/c1-17(23-7-8-24(27)37-23)16-38(35,36)30-21-10-13-32(26(21)34)22-6-5-19(14-20(22)28)25(33)31(2)12-9-18-4-3-11-29-15-18/h3-8,11,14-16,21,30H,9-10,12-13H2,1-2H3/b17-16+/t21-/m0/s1 CBPNGFHDUHIGKQ-PQORCFSTSA-N 226097 GTC000084A Coagulation factor X Homo sapiens 29.2 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226097&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962513 336293245 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395807 CN(CCc1c[nH]cn1)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C24H25ClFN5O4S2/c1-15(21-5-6-22(25)36-21)13-37(34,35)29-19-8-10-31(24(19)33)20-4-3-16(11-18(20)26)23(32)30(2)9-7-17-12-27-14-28-17/h3-6,11-14,19,29H,7-10H2,1-2H3,(H,27,28)/b15-13+/t19-/m0/s1 ZNMXNODRHJPABD-LLLGYDHXSA-N 226098 GTC000085A Coagulation factor X Homo sapiens 66.3 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226098&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 126962514 336293246 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395808 CN(C)C(=O)c1ccc(N2CC[C@H](N(CC3CC3)S(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C24H27ClFN3O4S2/c1-15(21-8-9-22(25)34-21)14-35(32,33)29(13-16-4-5-16)20-10-11-28(24(20)31)19-7-6-17(12-18(19)26)23(30)27(2)3/h6-9,12,14,16,20H,4-5,10-11,13H2,1-3H3/b15-14+/t20-/m0/s1 ATHUNKNQUKRTND-JWHUVLAVSA-N 226099 GTC000086A Coagulation factor X Homo sapiens 1.17 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226099&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11353217 336293247 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395809 CN(C)C(=O)c1ccc(N2CC[C@H](N(Cc3c(C)noc3C)S(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C26H28ClFN4O5S2/c1-15(23-8-9-24(27)38-23)14-39(35,36)32(13-19-16(2)29-37-17(19)3)22-10-11-31(26(22)34)21-7-6-18(12-20(21)28)25(33)30(4)5/h6-9,12,14,22H,10-11,13H2,1-5H3/b15-14+/t22-/m0/s1 OLOUIJIFSWXBBK-FRFYRWIFSA-N 226100 GTC000087A Coagulation factor X Homo sapiens 2.01 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226100&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11786688 336293248 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395810 CN(C)C(=O)c1ccc(N2CC[C@H](N(Cc3nccn3C)S(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C25H27ClFN5O4S2/c1-16(21-7-8-22(26)37-21)15-38(35,36)32(14-23-28-10-12-30(23)4)20-9-11-31(25(20)34)19-6-5-17(13-18(19)27)24(33)29(2)3/h5-8,10,12-13,15,20H,9,11,14H2,1-4H3/b16-15+/t20-/m0/s1 RUZPEOZKOWVNLW-APHAIJBRSA-N 226101 GTC000088A Coagulation factor X Homo sapiens 1.68 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226101&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11273218 336293249 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395811 CC(C)N([C@H]1CCN(C1=O)c1ccc(cc1F)C(=O)N(C)C)S(=O)(=O)\C=C(/C)c1ccc(Cl)s1 InChI=1S/C23H27ClFN3O4S2/c1-14(2)28(34(31,32)13-15(3)20-8-9-21(24)33-20)19-10-11-27(23(19)30)18-7-6-16(12-17(18)25)22(29)26(4)5/h6-9,12-14,19H,10-11H2,1-5H3/b15-13+/t19-/m0/s1 QYEXGIQFYMRBDD-LLLGYDHXSA-N 226102 GTC000089A Coagulation factor X Homo sapiens 1.67 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226102&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11455319 336293250 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395812 COCCN([C@H]1CCN(C1=O)c1ccc(cc1F)C(=O)N(C)C)S(=O)(=O)\C=C(/C)c1ccc(Cl)s1 InChI=1S/C23H27ClFN3O5S2/c1-15(20-7-8-21(24)34-20)14-35(31,32)28(11-12-33-4)19-9-10-27(23(19)30)18-6-5-16(13-17(18)25)22(29)26(2)3/h5-8,13-14,19H,9-12H2,1-4H3/b15-14+/t19-/m0/s1 LIPZVMNLDVCNQT-IQGVVSCOSA-N 226103 GTC000090A Coagulation factor X Homo sapiens 0.89 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226103&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11168752 336293251 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395813 CN(C)C(=O)c1ccc(N2CC[C@H](N(CCOC(C)(C)C)S(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C26H33ClFN3O5S2/c1-17(22-9-10-23(27)37-22)16-38(34,35)31(13-14-36-26(2,3)4)21-11-12-30(25(21)33)20-8-7-18(15-19(20)28)24(32)29(5)6/h7-10,15-16,21H,11-14H2,1-6H3/b17-16+/t21-/m0/s1 IKEJTENQOMIVLX-PQORCFSTSA-N 226104 GTC000091A Coagulation factor X Homo sapiens 1.14 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226104&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11319251 336293252 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395814 CN(C)C(=O)c1ccc(N2CC[C@H](N(Cc3nccnc3N)S(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C25H26ClFN6O4S2/c1-15(21-6-7-22(26)38-21)14-39(36,37)33(13-18-23(28)30-10-9-29-18)20-8-11-32(25(20)35)19-5-4-16(12-17(19)27)24(34)31(2)3/h4-7,9-10,12,14,20H,8,11,13H2,1-3H3,(H2,28,30)/b15-14+/t20-/m0/s1 IBXJKXYJJVUSJS-JWHUVLAVSA-N 226105 GTC000092A Coagulation factor X Homo sapiens 1.28 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226105&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11444718 336293253 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395815 CN(C)CCN([C@H]1CCN(C1=O)c1ccc(cc1F)C(=O)N(C)C)S(=O)(=O)\C=C(/C)c1ccc(Cl)s1 InChI=1S/C24H30ClFN4O4S2/c1-16(21-8-9-22(25)35-21)15-36(33,34)30(13-12-27(2)3)20-10-11-29(24(20)32)19-7-6-17(14-18(19)26)23(31)28(4)5/h6-9,14-15,20H,10-13H2,1-5H3/b16-15+/t20-/m0/s1 PDFXRHNKRATJSR-APHAIJBRSA-N 226106 GTC000093A Coagulation factor X Homo sapiens 97.7 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226106&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11192182 336293254 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395816 CN(C)C(=O)c1ccc(N2CC[C@H](N(CCOCC(N)=O)S(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C24H28ClFN4O6S2/c1-15(20-6-7-21(25)37-20)14-38(34,35)30(10-11-36-13-22(27)31)19-8-9-29(24(19)33)18-5-4-16(12-17(18)26)23(32)28(2)3/h4-7,12,14,19H,8-11,13H2,1-3H3,(H2,27,31)/b15-14+/t19-/m0/s1 XYHNRNHKHBRUJS-IQGVVSCOSA-N 226107 GTC000094A Coagulation factor X Homo sapiens 6.1 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226107&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11192566 336293255 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395817 CN(C)CCCN([C@H]1CCN(C1=O)c1ccc(cc1F)C(=O)N(C)C)S(=O)(=O)\C=C(/C)c1ccc(Cl)s1 InChI=1S/C25H32ClFN4O4S2/c1-17(22-9-10-23(26)36-22)16-37(34,35)31(13-6-12-28(2)3)21-11-14-30(25(21)33)20-8-7-18(15-19(20)27)24(32)29(4)5/h7-10,15-16,21H,6,11-14H2,1-5H3/b17-16+/t21-/m0/s1 KAYKHDZOLQGXAL-PQORCFSTSA-N 226108 GTC000095A Coagulation factor X Homo sapiens 10.78 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226108&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11250055 336293256 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395818 CN(C)C(=O)c1ccc(N2CC[C@H](N(Cc3ccccn3)S(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C26H26ClFN4O4S2/c1-17(23-9-10-24(27)37-23)16-38(35,36)32(15-19-6-4-5-12-29-19)22-11-13-31(26(22)34)21-8-7-18(14-20(21)28)25(33)30(2)3/h4-10,12,14,16,22H,11,13,15H2,1-3H3/b17-16+/t22-/m0/s1 XIEJZKJXYCREIR-QWYDYZLZSA-N 226109 GTC000096A Coagulation factor X Homo sapiens 0.641 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226109&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11215320 336293257 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395819 CN(C)C(=O)c1ccc(N2CC[C@H](N(C3CCCC3)S(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C25H29ClFN3O4S2/c1-16(22-10-11-23(26)35-22)15-36(33,34)30(18-6-4-5-7-18)21-12-13-29(25(21)32)20-9-8-17(14-19(20)27)24(31)28(2)3/h8-11,14-15,18,21H,4-7,12-13H2,1-3H3/b16-15+/t21-/m0/s1 LXDQDNYQBLWSNX-ANUWBXLYSA-N 226110 GTC000097A Coagulation factor X Homo sapiens 1.61 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226110&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11261410 336293258 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395820 NC(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C17H15ClFN3O4S2/c18-15-4-2-11(27-15)6-8-28(25,26)21-13-5-7-22(17(13)24)14-3-1-10(16(20)23)9-12(14)19/h1-4,6,8-9,13,21H,5,7H2,(H2,20,23)/b8-6+/t13-/m0/s1 ZLADJJKLKTWOER-CFNZNRNTSA-N 50306150 (S)-4-(3-(2-(5-chlorothiophen-2-yl)vinylsulfonamido)-2-oxopyrrolidin-1-yl)-3-fluorobenzamide::CHEMBL594515::GTC000099A Coagulation factor X Homo sapiens 7.4 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306150&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 46226322 104160511 CHEMBL594515 ZINC45350940 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395821 NC(=O)CN([C@H]1CCN(C1=O)c1ccc(cc1F)C(N)=O)S(=O)(=O)\C=C\c1ccc(Cl)s1 InChI=1S/C19H18ClFN4O5S2/c20-16-4-2-12(31-16)6-8-32(29,30)25(10-17(22)26)15-5-7-24(19(15)28)14-3-1-11(18(23)27)9-13(14)21/h1-4,6,8-9,15H,5,7,10H2,(H2,22,26)(H2,23,27)/b8-6+/t15-/m0/s1 IWCRFKQOSXDKKV-VFADXPBXSA-N 226111 GTC000100A Coagulation factor X Homo sapiens 4.47 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226111&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69753495 336293259 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395822 CN(C)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C19H19ClFN3O4S2/c1-23(2)18(25)12-3-5-16(14(21)11-12)24-9-7-15(19(24)26)22-30(27,28)10-8-13-4-6-17(20)29-13/h3-6,8,10-11,15,22H,7,9H2,1-2H3/b10-8+/t15-/m0/s1 YVFKLOGRKAMHKF-HQPKTYMTSA-N 50306148 (S)-4-(3-(2-(5-chlorothiophen-2-yl)vinylsulfonamido)-2-oxopyrrolidin-1-yl)-3-fluoro-N,N-dimethylbenzamide::CHEMBL607085::GTC000101A Coagulation factor X Homo sapiens 4.83 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306148&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 48U 4Y6D 46226324 104160509 CHEMBL607085 ZINC45387787 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395823 CNC(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C18H17ClFN3O4S2/c1-21-17(24)11-2-4-15(13(20)10-11)23-8-6-14(18(23)25)22-29(26,27)9-7-12-3-5-16(19)28-12/h2-5,7,9-10,14,22H,6,8H2,1H3,(H,21,24)/b9-7+/t14-/m0/s1 MRLVEBYZUBUEBU-KGXGESDWSA-N 50306149 (S)-4-(3-(2-(5-chlorothiophen-2-yl)vinylsulfonamido)-2-oxopyrrolidin-1-yl)-3-fluoro-N-methylbenzamide::CHEMBL594516::GTC000102A Coagulation factor X Homo sapiens 57.2 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306149&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 46226323 104160510 CHEMBL594516 ZINC45351722 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395824 CN(C)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)c3cc4ccc(Cl)cc4s3)C2=O)c(F)c1 InChI=1S/C21H19ClFN3O4S2/c1-25(2)20(27)13-4-6-17(15(23)9-13)26-8-7-16(21(26)28)24-32(29,30)19-10-12-3-5-14(22)11-18(12)31-19/h3-6,9-11,16,24H,7-8H2,1-2H3/t16-/m0/s1 QWSPOKCEAQQIPA-INIZCTEOSA-N 226112 GTC000103A Coagulation factor X Homo sapiens 5.55 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226112&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69755068 336293260 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395825 CN(C)C(=O)c1ccc(N2CC[C@H](N(CC(N)=O)S(=O)(=O)\C=C\c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C21H22ClFN4O5S2/c1-25(2)20(29)13-3-5-16(15(23)11-13)26-9-7-17(21(26)30)27(12-19(24)28)34(31,32)10-8-14-4-6-18(22)33-14/h3-6,8,10-11,17H,7,9,12H2,1-2H3,(H2,24,28)/b10-8+/t17-/m0/s1 IUPLTPUQZVHRKU-VMSUTVGLSA-N 226113 GTC000104A Coagulation factor X Homo sapiens 2.89 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226113&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69753182 336293261 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395826 CN(C)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)\C=C(/C)c3ccc(Cl)s3)C2=O)c(F)c1 InChI=1S/C20H21ClFN3O4S2/c1-12(17-6-7-18(21)30-17)11-31(28,29)23-15-8-9-25(20(15)27)16-5-4-13(10-14(16)22)19(26)24(2)3/h4-7,10-11,15,23H,8-9H2,1-3H3/b12-11+/t15-/m0/s1 UTCDFKQSXRXKKO-RUMSDORHSA-N 226114 GTC000105A Coagulation factor X Homo sapiens 1.16 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226114&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11698765 336293262 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 395827 CC(C)N(C)C(=O)c1ccc(N2CC[C@H](NS(=O)(=O)c3cc4ccc(Cl)cc4s3)C2=O)c(F)c1 InChI=1S/C23H23ClFN3O4S2/c1-13(2)27(3)22(29)15-5-7-19(17(25)10-15)28-9-8-18(23(28)30)26-34(31,32)21-11-14-4-6-16(24)12-20(14)33-21/h4-7,10-13,18,26H,8-9H2,1-3H3/t18-/m0/s1 OICQLLSBOAVDEG-SFHVURJKSA-N 226115 GTC000106A Coagulation factor X Homo sapiens 1688 D3R 10.7270/Q2BV7FGN aid1802761 D3R, DD D3R/Abbott http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=226115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=226115&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 69753641 336293263 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 408740 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32) QNZCBYKSOIHPEH-UHFFFAOYSA-N 19023 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Apixaban::BMS-562247::CHEMBL231779::US9938272, Example Apixaban Coagulation factor X Homo sapiens 0.075 7.4 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2010.535793 10.7270/Q2VX0FDF 21171894 aid1802999 Luettgen, JM; Knabb, RM; He, K; Pinto, DJ; Rendina, AR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19023&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GG2 2P16,6W70 10182969 46519072 72296 CHEMBL231779 DB06605 6390 ZINC11677837 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 408741 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32) QNZCBYKSOIHPEH-UHFFFAOYSA-N 19023 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Apixaban::BMS-562247::CHEMBL231779::US9938272, Example Apixaban Coagulation factor X Homo sapiens 0.14 7.4 31.00 C Curated from the literature by BindingDB 10.3109/14756366.2010.535793 10.7270/Q2VX0FDF 21171894 aid1802999 Luettgen, JM; Knabb, RM; He, K; Pinto, DJ; Rendina, AR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19023&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GG2 2P16,6W70 10182969 46519072 72296 CHEMBL231779 DB06605 6390 ZINC11677837 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 408742 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32) QNZCBYKSOIHPEH-UHFFFAOYSA-N 19023 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Apixaban::BMS-562247::CHEMBL231779::US9938272, Example Apixaban Coagulation factor X Homo sapiens 0.25 7.4 37.00 C Curated from the literature by BindingDB 10.3109/14756366.2010.535793 10.7270/Q2VX0FDF 21171894 aid1802999 Luettgen, JM; Knabb, RM; He, K; Pinto, DJ; Rendina, AR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19023&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GG2 2P16,6W70 10182969 46519072 72296 CHEMBL231779 DB06605 6390 ZINC11677837 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 408743 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32) QNZCBYKSOIHPEH-UHFFFAOYSA-N 19023 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Apixaban::BMS-562247::CHEMBL231779::US9938272, Example Apixaban Coagulation factor X Homo sapiens 0.40 7.4 43.00 C Curated from the literature by BindingDB 10.3109/14756366.2010.535793 10.7270/Q2VX0FDF 21171894 aid1802999 Luettgen, JM; Knabb, RM; He, K; Pinto, DJ; Rendina, AR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19023&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GG2 2P16,6W70 10182969 46519072 72296 CHEMBL231779 DB06605 6390 ZINC11677837 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 408744 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32) QNZCBYKSOIHPEH-UHFFFAOYSA-N 19023 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Apixaban::BMS-562247::CHEMBL231779::US9938272, Example Apixaban Coagulation factor X Homo sapiens 0.41 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2010.535793 10.7270/Q2VX0FDF 21171894 aid1803000 Luettgen, JM; Knabb, RM; He, K; Pinto, DJ; Rendina, AR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19023&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GG2 2P16,6W70 10182969 46519072 72296 CHEMBL231779 DB06605 6390 ZINC11677837 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 408745 COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32) QNZCBYKSOIHPEH-UHFFFAOYSA-N 19023 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide::Apixaban::BMS-562247::CHEMBL231779::US9938272, Example Apixaban Coagulation factor X Homo sapiens 0.72 7.5 37.00 C Curated from the literature by BindingDB 10.3109/14756366.2010.535793 10.7270/Q2VX0FDF 21171894 aid1803000 Luettgen, JM; Knabb, RM; He, K; Pinto, DJ; Rendina, AR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=19023&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search GG2 2P16,6W70 10182969 46519072 72296 CHEMBL231779 DB06605 6390 ZINC11677837 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415514 CS(=O)(=O)N1CCN(CC1)[C@H]1C[C@H](N(C1)C(=O)C1CCN(CC1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O InChI=1S/C24H35N7O6S/c1-38(36,37)30-12-10-28(11-13-30)19-14-20(21(32)27-18-4-2-17(3-5-18)23(34)35)31(15-19)22(33)16-6-8-29(9-7-16)24(25)26/h2-5,16,19-20H,6-15H2,1H3,(H3,25,26)(H,27,32)(H,34,35)/t19-,20-/m0/s1 QRFYQKCKNQTQSA-PMACEKPBSA-N 238251 US10336741, Example 9::US10882855, Example 9::US9394250, 9::US9585881, Example 9 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238251&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72550184 340131647 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415515 CS(=O)(=O)N1CCN(CC1)[C@H]1C[C@H](N(C1)C(=O)c1ccc(cc1)C(N)=N)C(=O)Nc1ccc(cc1)C(O)=O InChI=1S/C25H30N6O6S/c1-38(36,37)30-12-10-29(11-13-30)20-14-21(23(32)28-19-8-6-18(7-9-19)25(34)35)31(15-20)24(33)17-4-2-16(3-5-17)22(26)27/h2-9,20-21H,10-15H2,1H3,(H3,26,27)(H,28,32)(H,34,35)/t20-,21-/m0/s1 DCBBOIFLGAMQFC-SFTDATJTSA-N 238252 US10336741, Example 20::US10882855, Example 20::US9394250, 20::US9585881, Example 20 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238252&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72550185 340131648 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415516 OC(=O)c1ccc(NC(=O)[C@@H]2C[C@@H](CN2C(=O)\C=C\c2cc(Cl)ccc2-n2cnnn2)N2CCOCC2)cc1 InChI=1S/C26H26ClN7O5/c27-19-4-7-22(34-16-28-30-31-34)18(13-19)3-8-24(35)33-15-21(32-9-11-39-12-10-32)14-23(33)25(36)29-20-5-1-17(2-6-20)26(37)38/h1-8,13,16,21,23H,9-12,14-15H2,(H,29,36)(H,37,38)/b8-3+/t21-,23-/m0/s1 XKCJWVCNDOVAHF-VAEGLNEYSA-N 238253 US10336741, Example 37::US10882855, Example 37::US9394250, 37::US9585881, Example 37 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238253&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72550186 340131649 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415517 Clc1ccc(c(\C=C\C(=O)N2C[C@H](C[C@H]2C(=O)Nc2ccccc2)N2CCN(CC2)S(=O)(=O)c2ccccc2)c1)-n1cnnn1 InChI=1S/C31H31ClN8O4S/c32-24-12-13-28(40-22-33-35-36-40)23(19-24)11-14-30(41)39-21-26(20-29(39)31(42)34-25-7-3-1-4-8-25)37-15-17-38(18-16-37)45(43,44)27-9-5-2-6-10-27/h1-14,19,22,26,29H,15-18,20-21H2,(H,34,42)/b14-11+/t26-,29-/m0/s1 MOLPVSKHMAUZQO-ZXVVROJWSA-N 238254 US10882855, Example 39::US9394250, 39::US9585881, Example 39 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238254&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72550187 340131650 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415518 Clc1ccc(c(\C=C\C(=O)N2C[C@H](C[C@H]2C(=O)Nc2ccc3nn[nH]c3c2)N2CCOCC2)c1)-n1cnnn1 238255 US10336741, Example 43::US10882855, Example 43::US9394250, 43::US9585881, Example 43 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238255&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72550404 340131651 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415519 NC[C@H]1CC[C@@H](CC1)C(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(cc1)C(O)=O)N1CCN(CC1)S(=O)(=O)C1CC1 InChI=1S/C27H39N5O6S/c28-16-18-1-3-19(4-2-18)26(34)32-17-22(30-11-13-31(14-12-30)39(37,38)23-9-10-23)15-24(32)25(33)29-21-7-5-20(6-8-21)27(35)36/h5-8,18-19,22-24H,1-4,9-17,28H2,(H,29,33)(H,35,36)/t18-,19-,22-,24-/m0/s1 KPHTWWMYMFXYAQ-MWYJAUPDSA-N 238256 US10336741, Example 55::US10882855, Example 55::US9394250, 55::US9585881, Example 55 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238256&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72550405 340131652 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415520 C[C@H]1CN(CCN1S(N)(=O)=O)[C@H]1C[C@H](N(C1)C(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1)C(=O)Nc1ccccc1 InChI=1S/C26H30ClN9O4S/c1-18-15-33(11-12-36(18)41(28,39)40)22-14-24(26(38)30-21-5-3-2-4-6-21)34(16-22)25(37)10-7-19-13-20(27)8-9-23(19)35-17-29-31-32-35/h2-10,13,17-18,22,24H,11-12,14-16H2,1H3,(H,30,38)(H2,28,39,40)/b10-7+/t18-,22-,24-/m0/s1 ZTVWUADOYUCSOA-QFRTYVPDSA-N 238257 US10336741, Example 57::US10882855, Example 57::US9394250, 57::US9585881, Example 57 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238257&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 90033784 340131653 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415521 COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O 238258 US10882855, Example 69::US9394250, 69::US9585881, Example 69 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238258&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72550407 340131654 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415522 COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)c1ccc(cc1)C(N)=N)C1CCN(CC1)S(C)(=O)=O 238260 US10336741, Example 73::US10882855, Example 73::US9394250, 73::US9585881, Example 73 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238260&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72550625 340131656 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415523 COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)c1ccc(NC(N)=N)cc1)C1CCN(CC1)S(C)(=O)=O 238261 US10336741, Example 79::US10882855, Example 79::US9394250, 79::US9585881, Example 79 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238261&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72550626 340131657 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415524 COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)[C@H]1CCC(CC1)[C@H](C)N)C1CCN(CC1)S(C)(=O)=O 238262 US9394250, 86 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238262&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72550627 340131658 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415525 COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)N1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O 238263 US10336741, Example 88::US10882855, Example 88::US9394250, 88::US9585881, Example 88 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238263&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72550628 340131659 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415526 Cn1cc(Cl)c2c(F)c(ccc12)C(=O)N1C[C@H](C[C@H]1C(=O)Nc1ccc(cc1)C(O)=O)C1CCN(CC1)S(C)(=O)=O InChI=1S/C28H30ClFN4O6S/c1-32-15-21(29)24-22(32)8-7-20(25(24)30)27(36)34-14-18(16-9-11-33(12-10-16)41(2,39)40)13-23(34)26(35)31-19-5-3-17(4-6-19)28(37)38/h3-8,15-16,18,23H,9-14H2,1-2H3,(H,31,35)(H,37,38)/t18-,23-/m0/s1 WKLGVORXJYLGCX-MBSDFSHPSA-N 238264 US10336741, Example 93::US10882855, Example 93::US9394250, 93::US9585881, Example 93 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238264&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72550847 340131660 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415527 COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)\C=C\c1cc(Cl)ccc1-n1cnnn1)C1CCN(CC1)S(C)(=O)=O 238265 US10336741, Example 94::US10882855, Example 94::US9394250, 94::US9585881, Example 94 Coagulation factor X Homo sapiens >33000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238265&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72550848 340131661 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415528 COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)[C@H]1CC[C@H](CN)CC1)C1CCN(CC1)S(C)(=O)=O 238266 US10882855, Example 96::US9394250, 96::US9585881, Example 96 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238266&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72550850 340131662 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415529 COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O 238268 US10336741, Example 98::US10882855, Example 98::US9394250, 98::US9585881, Example 98 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238268&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72550849 340131664 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415530 COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CCN(CC1)C(N)=N)C1CCN(CC1)S(C)(=O)=O 238259 US10336741, Example 71::US10882855, Example 71::US9394250, 71::US9585881, Example 71 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238259&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 72551066 340131655 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 415531 COC(=O)Nc1ccc(cc1)-c1[nH]c(nc1Cl)[C@@H]1C[C@@H](CN1C(=O)C1CCC(CC1)C(N)=N)N1CCN(CC1)S(C)(=O)=O 238267 US9394250, 99 Coagulation factor X Homo sapiens >100000 US Patent 10.7270/Q2222SP5 aid1803158 US9394250 Imagawa, A; Kondo, T; Nishiyama, T; Courtney, S; Yarnold, C; Ichihara, O; Flanagan, S Ono Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238267&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 129012579 340131663 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 450587 CCOc1ccc(C[C@@H](NC(=O)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCc2ccc(CN)cc2)cc1 InChI=1S/C35H38N4O4/c1-2-43-30-19-17-26(18-20-30)22-32(38-33(40)29-11-7-4-8-12-29)35(42)39-31(21-25-9-5-3-6-10-25)34(41)37-24-28-15-13-27(23-36)14-16-28/h3-20,31-32H,2,21-24,36H2,1H3,(H,37,41)(H,38,40)(H,39,42)/t31-,32+/m0/s1 UCIXIQRCAGGOJY-AJQTZOPKSA-N 200012 US9234000, 3::US9512065, N-[(R)-1-[(S)-1-(4-aminomethyl-benzylcarbamoyl)-2-phenyl-ethylcarbamoyl]-2-(4-ethoxy-phenyl)-ethyl]-benzamide Coagulation factor X Homo sapiens >10000 US Patent 10.7270/Q2N878QN aid1803629 US9512065 Northen, JS; Mykytiuk, J Kalvista Pharmaceuticals Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=200012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=200012&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71185716 318589842 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50008757 Cl.CC(=O)N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)B(O)O InChI=1S/C21H33BN6O5.ClH/c1-14(29)26-16(13-15-7-3-2-4-8-15)20(31)28-12-6-9-17(28)19(30)27-18(22(32)33)10-5-11-25-21(23)24;/h2-4,7-8,16-18,32-33H,5-6,9-13H2,1H3,(H,26,29)(H,27,30)(H4,23,24,25);1H/t16-,17+,18+;/m1./s1 KXZSMOLMRHMZDG-PWGAQZMISA-N 50288632 Boropeptide::CHEMBL607008 Coagulation factor X Homo sapiens 9 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50288632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50288632&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 46878203 104130203 CHEMBL607008 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50124973 CC(C)=CC(=O)C[C@@H]1[C@@H]2[C@H](C[C@]3(C)C4=CC[C@H]5[C@@]6(C)[C@@H](CC[C@]5(C)[C@H]4CC[C@@]23C)OC6=O)OC1=O InChI=1S/C30H40O5/c1-16(2)13-17(31)14-18-24-21(34-25(18)32)15-29(5)20-7-8-22-27(3,19(20)9-12-28(24,29)4)11-10-23-30(22,6)26(33)35-23/h7,13,18-19,21-24H,8-12,14-15H2,1-6H3/t18-,19+,21+,22-,23-,24-,27-,28+,29-,30+/m1/s1 UAKRLLAUOQEYFN-PQNCNOJFSA-N 50072284 (1S,2R,4aR,6aS,6bS,7R,9aS,10aS)-2-Acetoxy-1,4a,6a,10a-tetramethyl-7-(4-methyl-2-oxo-pent-3-enyl)-8-oxo-2,3,4,4a,4b,5,6,6a,6b,7,8,9a,10,10a,12,12a-hexadecahydro-1H-9-oxa-pentaleno[2,1-a]phenanthrene-1-carboxylic acid::CHEMBL457155::GR-133686 Coagulation factor X Homo sapiens >20000 ChEMBL 10.1016/S0960-894X(98)00531-9 10.7270/Q2JQ105F 9873654 Finch, H; Pegg, NA; McLaren, J; Lowdon, A; Bolton, R; Coote, SJ; Dyer, U; Montana, JG; Owen, MR; Dowle, M; Buckley, D; Ross, BC; Campbell, C; Dix, C; Mooney, C; Man-Tang, C; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072284&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10696098 103965932 CHEMBL457155 ZINC26743681 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50013125 CN(CC(=O)N[C@H]1CCCC(C1O)C(N)=N)C(=O)[C@@H](CCCNC(N)=N)NS(=O)(=O)Cc1ccccc1 InChI=1S/C23H38N8O5S/c1-31(13-19(32)29-17-10-5-9-16(20(17)33)21(24)25)22(34)18(11-6-12-28-23(26)27)30-37(35,36)14-15-7-3-2-4-8-15/h2-4,7-8,16-18,20,30,33H,5-6,9-14H2,1H3,(H3,24,25)(H,29,32)(H4,26,27,28)/t16?,17-,18+,20?/m0/s1 ABJUGLXDGYDGLY-AGYKMIKPSA-N 50093057 (R)-5-Guanidino-2-phenylmethanesulfonylamino-pentanoic acid [((S)-3-carbamimidoyl-2-hydroxy-cyclohexylcarbamoyl)-methyl]-methyl-amide::CHEMBL431985 Coagulation factor X Homo sapiens 3.4 ChEMBL 10.1016/s0960-894x(00)00458-3 10.7270/Q25Q4VBR 11055344 Semple, JE; Levy, OE; Minami, NK; Owens, TD; Siev, DV Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50093057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50093057&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44314053 103991076 CHEMBL431985 ZINC26397374 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50013127 CCOC(=O)CNC(=O)C(=O)[C@H](Cc1ccccc1)NC(=O)CN(C)C(=O)[C@@H](CCCNC(N)=N)NS(=O)(=O)Cc1ccccc1 InChI=1S/C30H41N7O8S/c1-3-45-26(39)18-34-28(41)27(40)24(17-21-11-6-4-7-12-21)35-25(38)19-37(2)29(42)23(15-10-16-33-30(31)32)36-46(43,44)20-22-13-8-5-9-14-22/h4-9,11-14,23-24,36H,3,10,15-20H2,1-2H3,(H,34,41)(H,35,38)(H4,31,32,33)/t23-,24+/m1/s1 DEJIGJUTJUIFLI-RPWUZVMVSA-N 50093058 ((S)-3-{2-[((R)-5-Guanidino-2-phenylmethanesulfonylamino-pentanoyl)-methyl-amino]-acetylamino}-2-oxo-4-phenyl-butyrylamino)-acetic acid ethyl ester::CHEMBL309068 Coagulation factor X Homo sapiens 25 ChEMBL 10.1016/s0960-894x(00)00458-3 10.7270/Q25Q4VBR 11055344 Semple, JE; Levy, OE; Minami, NK; Owens, TD; Siev, DV Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50093058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50093058&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44313932 103991077 CHEMBL309068 ZINC26393445 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50013128 CCOC(=O)CNC(=O)C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CN(C)C(=O)[C@@H](CCCNC(N)=N)NS(=O)(=O)Cc1ccccc1 InChI=1S/C30H41N7O9S/c1-3-46-26(40)17-34-28(42)27(41)24(16-20-11-13-22(38)14-12-20)35-25(39)18-37(2)29(43)23(10-7-15-33-30(31)32)36-47(44,45)19-21-8-5-4-6-9-21/h4-6,8-9,11-14,23-24,36,38H,3,7,10,15-19H2,1-2H3,(H,34,42)(H,35,39)(H4,31,32,33)/t23-,24+/m1/s1 KIRCWUMMOSYFRV-RPWUZVMVSA-N 50093060 CHEMBL432159::[(S)-3-{2-[((R)-5-Guanidino-2-phenylmethanesulfonylamino-pentanoyl)-methyl-amino]-acetylamino}-4-(4-hydroxy-phenyl)-2-oxo-butyrylamino]-acetic acid ethyl ester; TFA Coagulation factor X Homo sapiens 7.6 ChEMBL 10.1016/s0960-894x(00)00458-3 10.7270/Q25Q4VBR 11055344 Semple, JE; Levy, OE; Minami, NK; Owens, TD; Siev, DV Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50093060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50093060&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44314265 103991079 CHEMBL432159 ZINC26386525 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50013129 CN(CC(=O)N[C@@H](Cc1ccccc1)C(=O)C(=O)NCC(=O)NCCc1ccccc1)C(=O)[C@@H](CCCNC(N)=N)NS(=O)(=O)Cc1ccccc1 InChI=1S/C36H46N8O7S/c1-44(35(49)29(18-11-20-40-36(37)38)43-52(50,51)25-28-16-9-4-10-17-28)24-32(46)42-30(22-27-14-7-3-8-15-27)33(47)34(48)41-23-31(45)39-21-19-26-12-5-2-6-13-26/h2-10,12-17,29-30,43H,11,18-25H2,1H3,(H,39,45)(H,41,48)(H,42,46)(H4,37,38,40)/t29-,30+/m1/s1 RYVSUTWQVTWKNM-IHLOFXLRSA-N 50093065 (R)-5-Guanidino-2-phenylmethanesulfonylamino-pentanoic acid ({(S)-1-benzyl-2-oxo-2-[(phenethylcarbamoyl-methyl)-carbamoyl]-ethylcarbamoyl}-methyl)-methyl-amide; TFA::CHEMBL74418 Coagulation factor X Homo sapiens 26 ChEMBL 10.1016/s0960-894x(00)00458-3 10.7270/Q25Q4VBR 11055344 Semple, JE; Levy, OE; Minami, NK; Owens, TD; Siev, DV Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50093065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50093065&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44314000 103991084 CHEMBL74418 ZINC26389196 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50009989 COc1cccc2N(CC(=O)N[C@H]3CCCN(C3O)C(N)=N)C(=O)[C@H](CCc12)NS(=O)(=O)Cc1ccccc1 InChI=1S/C26H34N6O6S/c1-38-22-11-5-10-21-18(22)12-13-20(30-39(36,37)16-17-7-3-2-4-8-17)25(35)32(21)15-23(33)29-19-9-6-14-31(24(19)34)26(27)28/h2-5,7-8,10-11,19-20,24,30,34H,6,9,12-16H2,1H3,(H3,27,28)(H,29,33)/t19-,20-,24?/m0/s1 BZIOCUVNHKVFDQ-ZRENRBBTSA-N 50081090 CHEMBL87502::N-((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-((S)-6-methoxy-2-oxo-3-phenylmethanesulfonylamino-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-acetamide; TFA Coagulation factor X Homo sapiens 27 ChEMBL 10.1016/s0960-894x(99)00417-5 10.7270/Q26M361R 10498211 Tamura, SY; Goldman, EA; Bergum, PW; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081090&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44320839 103981150 CHEMBL87502 ZINC26575582 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50009991 COc1ccc2N(CC(=O)N[C@H]3CCCN(C3O)C(N)=N)C(=O)[C@H](CCc2c1)NS(=O)(=O)CC1CCCCC1 InChI=1S/C26H40N6O6S/c1-38-19-10-12-22-18(14-19)9-11-21(30-39(36,37)16-17-6-3-2-4-7-17)25(35)32(22)15-23(33)29-20-8-5-13-31(24(20)34)26(27)28/h10,12,14,17,20-21,24,30,34H,2-9,11,13,15-16H2,1H3,(H3,27,28)(H,29,33)/t20-,21-,24?/m0/s1 DRTWJAWLWULICG-GAIPOIILSA-N 50081092 CHEMBL85238::N-((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-((S)-3-cyclohexylmethanesulfonylamino-7-methoxy-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-acetamide; TFA Coagulation factor X Homo sapiens 1.9 ChEMBL 10.1016/s0960-894x(99)00417-5 10.7270/Q26M361R 10498211 Tamura, SY; Goldman, EA; Bergum, PW; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081092&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10460541 103981152 CHEMBL85238 ZINC26576379 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50009993 NC(=N)N1CCC[C@H](NC(=O)CN2c3ccccc3CC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O InChI=1S/C25H32N6O5S/c26-25(27)30-14-6-10-19(23(30)33)28-22(32)15-31-21-11-5-4-9-18(21)12-13-20(24(31)34)29-37(35,36)16-17-7-2-1-3-8-17/h1-5,7-9,11,19-20,23,29,33H,6,10,12-16H2,(H3,26,27)(H,28,32)/t19-,20-,23?/m0/s1 VBWQNCMYUXVASP-ZXTYOHMPSA-N 50081086 CHEMBL314576::N-((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-acetamide; TFA Coagulation factor X Homo sapiens 17 ChEMBL 10.1016/s0960-894x(99)00417-5 10.7270/Q26M361R 10498211 Tamura, SY; Goldman, EA; Bergum, PW; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081086&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44320862 103981146 CHEMBL314576 ZINC26575991 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50011589 COC(=O)[C@@H]1CN(Cc2ccc(cc2)-c2ccccc2S(N)(=O)=O)C[C@H]1c1cccc(c1)C(N)=N InChI=1S/C26H28N4O4S/c1-34-26(31)23-16-30(15-22(23)19-5-4-6-20(13-19)25(27)28)14-17-9-11-18(12-10-17)21-7-2-3-8-24(21)35(29,32)33/h2-13,22-23H,14-16H2,1H3,(H3,27,28)(H2,29,32,33)/t22-,23+/m0/s1 VXVOMLLAAQVNLR-XZOQPEGZSA-N 50076907 (3S,4R)-4-(3-Carbamimidoyl-phenyl)-1-(2'-sulfamoyl-biphenyl-4-ylmethyl)-pyrrolidine-3-carboxylic acid methyl ester with 2M of TFA::CHEMBL18225 Coagulation factor X Homo sapiens 4.80 ChEMBL 10.1016/s0960-894x(99)00164-x 10.7270/Q20V8BZZ 10328312 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076907&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 15463576 103969772 CHEMBL18225 ZINC28219356 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50013746 NC(=N)N1CCC(C[C@@H](NS(=O)(=O)Cc2ccccc2C(O)=O)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)CC1 InChI=1S/C25H39N9O7S/c26-24(27)33-10-7-15(8-11-33)12-19(32-42(40,41)14-16-4-1-2-5-17(16)23(38)39)21(36)30-13-20(35)31-18-6-3-9-34(22(18)37)25(28)29/h1-2,4-5,15,18-19,22,32,37H,3,6-14H2,(H3,26,27)(H3,28,29)(H,30,36)(H,31,35)(H,38,39)/t18-,19+,22?/m0/s1 HFVSFLXWTFMTFO-ZKTCVHQMSA-N 50087646 2-{[(R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-methyl]-carbamoyl}-2-(1-carbamimidoyl-piperidin-4-yl)-ethylsulfamoyl]-methyl}-benzoic acid; TFA::CHEMBL163218 Coagulation factor X Homo sapiens 5.3 ChEMBL 10.1016/s0960-894x(00)00105-0 10.7270/Q2D50M5R 10782677 Tamura, SY; Levy, OE; Uong, TH; Reiner, JE; Goldman, EA; Ho, JZ; Cohen, CR; Bergum, PW; Nutt, RF; Brunck, TK; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50087646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50087646&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44377550 103986680 CHEMBL163218 ZINC14128123 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50013757 NC(=N)N1CCCC(C[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)C1 InChI=1S/C24H39N9O5S/c25-23(26)32-10-4-8-17(14-32)12-19(31-39(37,38)15-16-6-2-1-3-7-16)21(35)29-13-20(34)30-18-9-5-11-33(22(18)36)24(27)28/h1-3,6-7,17-19,22,31,36H,4-5,8-15H2,(H3,25,26)(H3,27,28)(H,29,35)(H,30,34)/t17?,18-,19+,22?/m0/s1 CKRQXNYHHJWLPU-LECRGTDLSA-N 50087636 (R)-N-[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-methyl]-3-(1-carbamimidoyl-piperidin-3-yl)-2-phenylmethanesulfonylamino-propionamide; TFA::CHEMBL162443 Coagulation factor X Homo sapiens 0.920 ChEMBL 10.1016/s0960-894x(00)00105-0 10.7270/Q2D50M5R 10782677 Tamura, SY; Levy, OE; Uong, TH; Reiner, JE; Goldman, EA; Ho, JZ; Cohen, CR; Bergum, PW; Nutt, RF; Brunck, TK; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50087636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50087636&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10460564 103986670 CHEMBL162443 ZINC27852354 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50013760 NC(=N)N1CCCC(C[C@@H](NS(=O)(=O)Cc2ccccc2C(O)=O)C(=O)NCC(=O)N[C@H]2CCCN(C2O)C(N)=N)C1 InChI=1S/C25H39N9O7S/c26-24(27)33-9-3-5-15(13-33)11-19(32-42(40,41)14-16-6-1-2-7-17(16)23(38)39)21(36)30-12-20(35)31-18-8-4-10-34(22(18)37)25(28)29/h1-2,6-7,15,18-19,22,32,37H,3-5,8-14H2,(H3,26,27)(H3,28,29)(H,30,36)(H,31,35)(H,38,39)/t15?,18-,19+,22?/m0/s1 BIQZIGMQDFWFKF-ICZWNRPBSA-N 50087637 2-{[(R)-1-{[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-methyl]-carbamoyl}-2-(1-carbamimidoyl-piperidin-3-yl)-ethylsulfamoyl]-methyl}-benzoic acid; TFA::CHEMBL435448 Coagulation factor X Homo sapiens 2.1 ChEMBL 10.1016/s0960-894x(00)00105-0 10.7270/Q2D50M5R 10782677 Tamura, SY; Levy, OE; Uong, TH; Reiner, JE; Goldman, EA; Ho, JZ; Cohen, CR; Bergum, PW; Nutt, RF; Brunck, TK; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50087637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50087637&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44377558 103986671 CHEMBL435448 ZINC27859363 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50205641 C\C(=C(/F)C(=O)Nc1ccc(cc1Cl)-c1ccccc1S(N)(=O)=O)c1ccc(F)c(c1)C(N)=N InChI=1S/C23H19ClF2N4O3S/c1-12(13-6-8-18(25)16(10-13)22(27)28)21(26)23(31)30-19-9-7-14(11-17(19)24)15-4-2-3-5-20(15)34(29,32)33/h2-11H,1H3,(H3,27,28)(H,30,31)(H2,29,32,33)/b21-12+ RTEUQXCVRROFGK-CIAFOILYSA-N 50113598 (Z)-3-(3-Carbamimidoyl-4-fluoro-phenyl)-2-fluoro-but-2-enoic acid (3-chloro-2'-sulfamoyl-biphenyl-4-yl)-amide::CHEMBL39297 Coagulation factor X Homo sapiens 0.740000 ChEMBL 10.1016/s0960-894x(02)00199-3 10.7270/Q2P84B6X 12031331 Song, Y; Clizbe, L; Bhakta, C; Teng, W; Li, W; Wu, Y; Jia, ZJ; Zhang, P; Wang, L; Doughan, B; Su, T; Kanter, J; Woolfrey, J; Wong, P; Huang, B; Tran, K; Sinha, U; Park, G; Reed, A; Malinowski, J; Hollenbach, S; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50113598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50113598&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44284786 104007872 51689 CHEMBL39297 ZINC13442400 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50016374 C\C(=C(/F)C(=O)Nc1ccc(cc1Cl)-c1ccccc1S(N)(=O)=O)c1ccc(F)c(c1)C(N)=N InChI=1S/C23H19ClF2N4O3S/c1-12(13-6-8-18(25)16(10-13)22(27)28)21(26)23(31)30-19-9-7-14(11-17(19)24)15-4-2-3-5-20(15)34(29,32)33/h2-11H,1H3,(H3,27,28)(H,30,31)(H2,29,32,33)/b21-12+ RTEUQXCVRROFGK-CIAFOILYSA-N 50113598 (Z)-3-(3-Carbamimidoyl-4-fluoro-phenyl)-2-fluoro-but-2-enoic acid (3-chloro-2'-sulfamoyl-biphenyl-4-yl)-amide::CHEMBL39297 Coagulation factor X Homo sapiens 0.180000 ChEMBL 10.1016/s0960-894x(02)00199-3 10.7270/Q2P84B6X 12031331 Song, Y; Clizbe, L; Bhakta, C; Teng, W; Li, W; Wu, Y; Jia, ZJ; Zhang, P; Wang, L; Doughan, B; Su, T; Kanter, J; Woolfrey, J; Wong, P; Huang, B; Tran, K; Sinha, U; Park, G; Reed, A; Malinowski, J; Hollenbach, S; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50113598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50113598&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44284786 104007872 51689 CHEMBL39297 ZINC13442400 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50016758 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cc2ccccc2cc1F InChI=1S/C27H21FN4O3S/c1-17-14-25(32(31-17)24-16-20-7-3-2-6-19(20)15-23(24)28)27(33)30-21-12-10-18(11-13-21)22-8-4-5-9-26(22)36(29,34)35/h2-16H,1H3,(H,30,33)(H2,29,34,35) STHFXJMXOVWINY-UHFFFAOYSA-N 50114434 2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide::CHEMBL41982 Coagulation factor X Homo sapiens 9 ChEMBL 10.1016/s0960-894x(02)00239-1 10.7270/Q2VT1RFZ 12039583 Jia, ZJ; Wu, Y; Huang, W; Goldman, E; Zhang, P; Woolfrey, J; Wong, P; Huang, B; Sinha, U; Park, G; Reed, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114434&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9827306 104008510 CHEMBL41982 ZINC01494901 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50016745 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cc2ccccc2cc1F InChI=1S/C27H21FN4O3S/c1-17-14-25(32(31-17)24-16-20-7-3-2-6-19(20)15-23(24)28)27(33)30-21-12-10-18(11-13-21)22-8-4-5-9-26(22)36(29,34)35/h2-16H,1H3,(H,30,33)(H2,29,34,35) STHFXJMXOVWINY-UHFFFAOYSA-N 50114434 2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide::CHEMBL41982 Coagulation factor X Homo sapiens 5.7 ChEMBL 10.1016/s0960-894x(02)00239-1 10.7270/Q2VT1RFZ 12039583 Jia, ZJ; Wu, Y; Huang, W; Goldman, E; Zhang, P; Woolfrey, J; Wong, P; Huang, B; Sinha, U; Park, G; Reed, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114434&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9827306 104008510 CHEMBL41982 ZINC01494901 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50016857 C\C(=C(/F)C(=O)Nc1ccc(cc1Br)-c1ccccc1S(N)(=O)=O)c1ccc2ccnc(N)c2c1 InChI=1S/C25H20BrFN4O3S/c1-14(16-7-6-15-10-11-30-24(28)19(15)12-16)23(27)25(32)31-21-9-8-17(13-20(21)26)18-4-2-3-5-22(18)35(29,33)34/h2-13H,1H3,(H2,28,30)(H,31,32)(H2,29,33,34)/b23-14+ LWKKDTXFIYFHNG-OEAKJJBVSA-N 50115936 (E)-3-(1-Amino-isoquinolin-7-yl)-2-fluoro-but-2-enoic acid (3-bromo-2'-sulfamoyl-biphenyl-4-yl)-amide::CHEMBL63088 Coagulation factor X Homo sapiens 1.3 ChEMBL 10.1016/s0960-894x(02)00304-9 10.7270/Q2PZ584G 12113838 Song, Y; Clizbe, L; Bhakta, C; Teng, W; Li, W; Wong, P; Huang, B; Sinha, U; Park, G; Reed, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115936&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9829120 104009764 51689 CHEMBL63088 ZINC26173538 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50016858 C\C(=C(/F)C(=O)Nc1ccc(cc1Cl)-c1ccccc1S(N)(=O)=O)c1ccc2ccnc(N)c2c1 InChI=1S/C25H20ClFN4O3S/c1-14(16-7-6-15-10-11-30-24(28)19(15)12-16)23(27)25(32)31-21-9-8-17(13-20(21)26)18-4-2-3-5-22(18)35(29,33)34/h2-13H,1H3,(H2,28,30)(H,31,32)(H2,29,33,34)/b23-14+ PZQXOASUPDYJBC-OEAKJJBVSA-N 50115933 (E)-3-(1-Amino-isoquinolin-7-yl)-2-fluoro-but-2-enoic acid (3-chloro-2'-sulfamoyl-biphenyl-4-yl)-amide::CHEMBL63041 Coagulation factor X Homo sapiens 11 ChEMBL 10.1016/s0960-894x(02)00304-9 10.7270/Q2PZ584G 12113838 Song, Y; Clizbe, L; Bhakta, C; Teng, W; Li, W; Wong, P; Huang, B; Sinha, U; Park, G; Reed, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115933&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10029343 104009761 51689 CHEMBL63041 ZINC26174730 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50026933 OC1CCN(CC1)c1ccccc1-c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 InChI=1S/C30H26Cl2N4O3/c31-21-9-11-26(25(17-21)30(39)35-28-12-10-22(32)18-33-28)34-29(38)20-7-5-19(6-8-20)24-3-1-2-4-27(24)36-15-13-23(37)14-16-36/h1-12,17-18,23,37H,13-16H2,(H,34,38)(H,33,35,39) OOXMIJAEJWFLEK-UHFFFAOYSA-N 50142129 2'-(4-Hydroxy-piperidin-1-yl)-biphenyl-4-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenyl]-amide::CHEMBL174815 Coagulation factor X Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2003.11.079 10.7270/Q21V5DF7 15013006 Zhang, P; Bao, L; Zuckett, JF; Goldman, EA; Jia, ZJ; Arfsten, A; Edwards, S; Sinha, U; Hutchaleelaha, A; Park, G; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142129&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44386419 104031559 CHEMBL174815 ZINC28095355 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50026934 CC(N)=NCc1ccccc1-c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 InChI=1S/C28H23Cl2N5O2/c1-17(31)32-15-20-4-2-3-5-23(20)18-6-8-19(9-7-18)27(36)34-25-12-10-21(29)14-24(25)28(37)35-26-13-11-22(30)16-33-26/h2-14,16H,15H2,1H3,(H2,31,32)(H,34,36)(H,33,35,37) HIJFDIOXAYJNDY-UHFFFAOYSA-N 50142125 2'-(Acetimidoylamino-methyl)-biphenyl-4-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenyl]-amide::CHEMBL171854 Coagulation factor X Homo sapiens 0.700000 ChEMBL 10.1016/j.bmcl.2003.11.079 10.7270/Q21V5DF7 15013006 Zhang, P; Bao, L; Zuckett, JF; Goldman, EA; Jia, ZJ; Arfsten, A; Edwards, S; Sinha, U; Hutchaleelaha, A; Park, G; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142125&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44385552 104031555 CHEMBL171854 ZINC28017210 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50026935 NC(N)=NCc1ccccc1-c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 InChI=1S/C27H22Cl2N6O2/c28-19-9-11-23(22(13-19)26(37)35-24-12-10-20(29)15-32-24)34-25(36)17-7-5-16(6-8-17)21-4-2-1-3-18(21)14-33-27(30)31/h1-13,15H,14H2,(H,34,36)(H4,30,31,33)(H,32,35,37) IADWULQKYSCHHK-UHFFFAOYSA-N 50142126 2'-Guanidinomethyl-biphenyl-4-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenyl]-amide::CHEMBL173878 Coagulation factor X Homo sapiens 1.2 ChEMBL 10.1016/j.bmcl.2003.11.079 10.7270/Q21V5DF7 15013006 Zhang, P; Bao, L; Zuckett, JF; Goldman, EA; Jia, ZJ; Arfsten, A; Edwards, S; Sinha, U; Hutchaleelaha, A; Park, G; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142126&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44386116 104031556 CHEMBL173878 ZINC28098071 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50026937 CC(=N)NCc1cccc(c1)-c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 InChI=1S/C28H23Cl2N5O2/c1-17(31)32-15-18-3-2-4-21(13-18)19-5-7-20(8-6-19)27(36)34-25-11-9-22(29)14-24(25)28(37)35-26-12-10-23(30)16-33-26/h2-14,16H,15H2,1H3,(H2,31,32)(H,34,36)(H,33,35,37) FFYARTBJFPGFQN-UHFFFAOYSA-N 50142091 3'-(Acetimidoylamino-methyl)-biphenyl-4-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenyl]-amide::CHEMBL425142 Coagulation factor X Homo sapiens 4.4 ChEMBL 10.1016/j.bmcl.2003.11.079 10.7270/Q21V5DF7 15013006 Zhang, P; Bao, L; Zuckett, JF; Goldman, EA; Jia, ZJ; Arfsten, A; Edwards, S; Sinha, U; Hutchaleelaha, A; Park, G; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142091&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44385924 104031521 CHEMBL425142 ZINC28098548 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50026938 CN1CCCN(CC1)c1ccccc1-c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 InChI=1S/C31H29Cl2N5O2/c1-37-15-4-16-38(18-17-37)28-6-3-2-5-25(28)21-7-9-22(10-8-21)30(39)35-27-13-11-23(32)19-26(27)31(40)36-29-14-12-24(33)20-34-29/h2-3,5-14,19-20H,4,15-18H2,1H3,(H,35,39)(H,34,36,40) GBXQTAMUKOSFPP-UHFFFAOYSA-N 50142100 2'-(4-Methyl-[1,4]diazepan-1-yl)-biphenyl-4-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenyl]-amide::CHEMBL367451 Coagulation factor X Homo sapiens 3.1 ChEMBL 10.1016/j.bmcl.2003.11.079 10.7270/Q21V5DF7 15013006 Zhang, P; Bao, L; Zuckett, JF; Goldman, EA; Jia, ZJ; Arfsten, A; Edwards, S; Sinha, U; Hutchaleelaha, A; Park, G; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142100&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44385447 104031530 CHEMBL367451 ZINC28085960 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50026939 CN1CCN(CC1)c1ccccc1-c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 InChI=1S/C30H27Cl2N5O2/c1-36-14-16-37(17-15-36)27-5-3-2-4-24(27)20-6-8-21(9-7-20)29(38)34-26-12-10-22(31)18-25(26)30(39)35-28-13-11-23(32)19-33-28/h2-13,18-19H,14-17H2,1H3,(H,34,38)(H,33,35,39) FIXOUFMNZULNKP-UHFFFAOYSA-N 50142103 2'-(4-Methyl-piperazin-1-yl)-biphenyl-4-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenyl]-amide::CHEMBL444809 Coagulation factor X Homo sapiens 3.5 ChEMBL 10.1016/j.bmcl.2003.11.079 10.7270/Q21V5DF7 15013006 Zhang, P; Bao, L; Zuckett, JF; Goldman, EA; Jia, ZJ; Arfsten, A; Edwards, S; Sinha, U; Hutchaleelaha, A; Park, G; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142103&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44385561 104031533 CHEMBL444809 ZINC28092045 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50026942 CN(C)C(=N)c1cccc(c1)-c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 InChI=1S/C28H23Cl2N5O2/c1-35(2)26(31)20-5-3-4-19(14-20)17-6-8-18(9-7-17)27(36)33-24-12-10-21(29)15-23(24)28(37)34-25-13-11-22(30)16-32-25/h3-16,31H,1-2H3,(H,33,36)(H,32,34,37) AGSZXFWXEIGOTP-UHFFFAOYSA-N 50142096 3'-(N,N-Dimethyl-carbamimidoyl)-biphenyl-4-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenyl]-amide::CHEMBL368984 Coagulation factor X Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2003.11.079 10.7270/Q21V5DF7 15013006 Zhang, P; Bao, L; Zuckett, JF; Goldman, EA; Jia, ZJ; Arfsten, A; Edwards, S; Sinha, U; Hutchaleelaha, A; Park, G; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142096&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44387120 104031526 CHEMBL368984 ZINC28114748 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50026943 OC(=O)C1CCN(CC1)c1ccccc1-c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 InChI=1S/C31H26Cl2N4O4/c32-22-9-11-26(25(17-22)30(39)36-28-12-10-23(33)18-34-28)35-29(38)20-7-5-19(6-8-20)24-3-1-2-4-27(24)37-15-13-21(14-16-37)31(40)41/h1-12,17-18,21H,13-16H2,(H,35,38)(H,40,41)(H,34,36,39) DFODFKSDZXIEHN-UHFFFAOYSA-N 50142111 1-{4'-[4-Chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenylcarbamoyl]-biphenyl-2-yl}-piperidine-4-carboxylic acid::CHEMBL174330 Coagulation factor X Homo sapiens 0.400000 ChEMBL 10.1016/j.bmcl.2003.11.079 10.7270/Q21V5DF7 15013006 Zhang, P; Bao, L; Zuckett, JF; Goldman, EA; Jia, ZJ; Arfsten, A; Edwards, S; Sinha, U; Hutchaleelaha, A; Park, G; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142111&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44385893 104031541 CHEMBL174330 ZINC28092487 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50023653 NC(=N)c1cccc(c1)C1=NOC(Cn2cnnn2)(C1)C(=O)Nc1ccc(cn1)-c1ccccc1S(N)(=O)=O InChI=1S/C24H22N10O4S/c25-22(26)16-5-3-4-15(10-16)19-11-24(38-31-19,13-34-14-29-32-33-34)23(35)30-21-9-8-17(12-28-21)18-6-1-2-7-20(18)39(27,36)37/h1-10,12,14H,11,13H2,(H3,25,26)(H2,27,36,37)(H,28,30,35) NWIZWPMWIKFVDY-UHFFFAOYSA-N 50079240 3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyridin-2-yl]-amide; TFA::CHEMBL7651::CHEMBL93210 Coagulation factor X Homo sapiens 0.110000 ChEMBL 10.1016/s0960-894x(03)00080-5 10.7270/Q21R6PWQ 12643903 Quan, ML; Ellis, CD; He, MY; Liauw, AY; Lam, PY; Rossi, KA; Knabb, RM; Luettgen, JM; Wright, MR; Wong, PC; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079240&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10794450 103971553 CHEMBL7651CHEMBL93210 ZINC14096405 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50023669 Nc1cc(ccc1Cl)C1=NOC(Cn2cnnn2)(C1)C(=O)Nc1ccc(cn1)-c1ccccc1S(N)(=O)=O InChI=1S/C23H20ClN9O4S/c24-17-7-5-14(9-18(17)25)19-10-23(37-30-19,12-33-13-28-31-32-33)22(34)29-21-8-6-15(11-27-21)16-3-1-2-4-20(16)38(26,35)36/h1-9,11,13H,10,12,25H2,(H2,26,35,36)(H,27,29,34) GWMQLCDSIBPQFB-UHFFFAOYSA-N 50125237 3-(3-Amino-4-chloro-phenyl)-5-tetrazol-1-ylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyridin-2-yl]-amide::CHEMBL268225 Coagulation factor X Homo sapiens 320 ChEMBL 10.1016/s0960-894x(03)00080-5 10.7270/Q21R6PWQ 12643903 Quan, ML; Ellis, CD; He, MY; Liauw, AY; Lam, PY; Rossi, KA; Knabb, RM; Luettgen, JM; Wright, MR; Wong, PC; Wexler, RR Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50125237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50125237&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44264885 104017465 CHEMBL268225 ZINC25975713 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50026988 Clc1ccc(NC(=O)c2cc(Cl)ccc2NC(=O)c2ccc(cc2)-c2ccccc2N2CCNCC2)nc1 InChI=1S/C29H25Cl2N5O2/c30-21-9-11-25(24(17-21)29(38)35-27-12-10-22(31)18-33-27)34-28(37)20-7-5-19(6-8-20)23-3-1-2-4-26(23)36-15-13-32-14-16-36/h1-12,17-18,32H,13-16H2,(H,34,37)(H,33,35,38) NRANTPWFPSRULP-UHFFFAOYSA-N 50142106 2'-Piperazin-1-yl-biphenyl-4-carboxylic acid [4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)-phenyl]-amide::CHEMBL369130 Coagulation factor X Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2003.11.079 10.7270/Q21V5DF7 15013006 Zhang, P; Bao, L; Zuckett, JF; Goldman, EA; Jia, ZJ; Arfsten, A; Edwards, S; Sinha, U; Hutchaleelaha, A; Park, G; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142106&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44385953 104031536 CHEMBL369130 ZINC28101301 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50026994 CNC(=N)N(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 InChI=1S/C23H22Cl2N6O2/c1-27-23(26)31(2)13-14-3-5-15(6-4-14)21(32)29-19-9-7-16(24)11-18(19)22(33)30-20-10-8-17(25)12-28-20/h3-12H,13H2,1-2H3,(H2,26,27)(H,29,32)(H,28,30,33) ZZWYWUIPVCUVLM-UHFFFAOYSA-N 50142169 5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(N,N'-dimethyl-guanidinomethyl)-benzoylamino]-benzamide::CHEMBL369681 Coagulation factor X Homo sapiens 0.200000 ChEMBL 10.1016/j.bmcl.2003.11.080 10.7270/Q2X34WXD 15013007 Zhang, P; Bao, L; Zuckett, JF; Jia, ZJ; Woolfrey, J; Arfsten, A; Edwards, S; Sinha, U; Hutchaleelaha, A; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142169&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44385998 104031599 CHEMBL369681 ZINC28099250 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027022 CN(C)Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 InChI=1S/C22H20Cl2N4O2/c1-28(2)13-14-3-5-15(6-4-14)21(29)26-19-9-7-16(23)11-18(19)22(30)27-20-10-8-17(24)12-25-20/h3-12H,13H2,1-2H3,(H,26,29)(H,25,27,30) MNVTXUPCTQRIEV-UHFFFAOYSA-N 50142146 5-Chloro-N-(5-chloro-pyridin-2-yl)-2-(4-dimethylaminomethyl-benzoylamino)-benzamide::CHEMBL369086 Coagulation factor X Homo sapiens 4 ChEMBL 10.1016/j.bmcl.2003.11.080 10.7270/Q2X34WXD 15013007 Zhang, P; Bao, L; Zuckett, JF; Jia, ZJ; Woolfrey, J; Arfsten, A; Edwards, S; Sinha, U; Hutchaleelaha, A; Lambing, JL; Hollenbach, SJ; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142146&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44385935 104031576 CHEMBL369086 ZINC28098610 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027107 CN(C)Cc1ccccc1-c1ccc(NC(=O)c2cc(C)nn2-c2ccc3cc(Cl)ccc3c2)c(F)c1 InChI=1S/C30H26ClFN4O/c1-19-14-29(36(34-19)25-12-9-20-15-24(31)11-8-21(20)16-25)30(37)33-28-13-10-22(17-27(28)32)26-7-5-4-6-23(26)18-35(2)3/h4-17H,18H2,1-3H3,(H,33,37) MTGLNKLJXIUNBV-UHFFFAOYSA-N 50140386 2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-dimethylaminomethyl-3-fluoro-biphenyl-4-yl)-amide::CHEMBL277949 Coagulation factor X Homo sapiens 1.5 ChEMBL 10.1016/j.bmcl.2003.12.053 10.7270/Q2VD6XV5 14980670 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140386&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44274017 104029975 CHEMBL277949 ZINC28238972 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027110 CN(C)Cc1nccn1-c1ccc(NC(=O)c2cc(C)nn2-c2ccc3cc(Cl)ccc3c2)c(F)c1 InChI=1S/C27H24ClFN6O/c1-17-12-25(35(32-17)22-7-5-18-13-20(28)6-4-19(18)14-22)27(36)31-24-9-8-21(15-23(24)29)34-11-10-30-26(34)16-33(2)3/h4-15H,16H2,1-3H3,(H,31,36) LLDFKUNAZJSYRJ-UHFFFAOYSA-N 50140363 2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid [4-(2-dimethylaminomethyl-imidazol-1-yl)-2-fluoro-phenyl]-amide::CHEMBL279287 Coagulation factor X Homo sapiens 1.1 ChEMBL 10.1016/j.bmcl.2003.12.053 10.7270/Q2VD6XV5 14980670 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140363&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44273935 104029952 CHEMBL279287 ZINC28239941 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027111 Cc1cc(C(=O)Nc2ccc(cc2)C(=O)N2CCCC2)n(n1)-c1ccc2cc(Cl)ccc2c1 InChI=1S/C26H23ClN4O2/c1-17-14-24(31(29-17)23-11-7-19-15-21(27)8-4-20(19)16-23)25(32)28-22-9-5-18(6-10-22)26(33)30-12-2-3-13-30/h4-11,14-16H,2-3,12-13H2,1H3,(H,28,32) HZWWMRNNXWFLMB-UHFFFAOYSA-N 50140382 2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid [4-(pyrrolidine-1-carbonyl)-phenyl]-amide::CHEMBL21065 Coagulation factor X Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2003.12.053 10.7270/Q2VD6XV5 14980670 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140382&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44273754 104029971 CHEMBL21065 ZINC28235325 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027114 Cc1cc(C(=O)Nc2ccc(cc2)N2CCCCC2=O)n(n1)-c1ccc2cc(Cl)ccc2c1 InChI=1S/C26H23ClN4O2/c1-17-14-24(31(29-17)23-10-6-18-15-20(27)7-5-19(18)16-23)26(33)28-21-8-11-22(12-9-21)30-13-3-2-4-25(30)32/h5-12,14-16H,2-4,13H2,1H3,(H,28,33) MXOVIZLCZVKFEA-UHFFFAOYSA-N 50140387 2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid [4-(2-oxo-piperidin-1-yl)-phenyl]-amide::CHEMBL20660 Coagulation factor X Homo sapiens 1.1 ChEMBL 10.1016/j.bmcl.2003.12.053 10.7270/Q2VD6XV5 14980670 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140387&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44273701 104029976 CHEMBL20660 ZINC28233542 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027116 Cc1cc(C(=O)Nc2ccc(cc2)N2CCOCC2=O)n(n1)-c1ccc2cc(Cl)ccc2c1 InChI=1S/C25H21ClN4O3/c1-16-12-23(30(28-16)22-7-3-17-13-19(26)4-2-18(17)14-22)25(32)27-20-5-8-21(9-6-20)29-10-11-33-15-24(29)31/h2-9,12-14H,10-11,15H2,1H3,(H,27,32) GBNYOANAAKFYIH-UHFFFAOYSA-N 50140394 2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide::CHEMBL279212 Coagulation factor X Homo sapiens 0.300000 ChEMBL 10.1016/j.bmcl.2003.12.053 10.7270/Q2VD6XV5 14980670 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140394&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44273703 104029983 CHEMBL279212 ZINC28233551 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027118 Cc1cc(C(=O)Nc2ccc(cc2F)N2CCOCC2=O)n(n1)-c1ccc2cc(Cl)ccc2c1 InChI=1S/C25H20ClFN4O3/c1-15-10-23(31(29-15)20-5-3-16-11-18(26)4-2-17(16)12-20)25(33)28-22-7-6-19(13-21(22)27)30-8-9-34-14-24(30)32/h2-7,10-13H,8-9,14H2,1H3,(H,28,33) UPCNRLYOUPHLAH-UHFFFAOYSA-N 50140388 2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid [2-fluoro-4-(3-oxo-morpholin-4-yl)-phenyl]-amide::CHEMBL20714 Coagulation factor X Homo sapiens 0.500000 ChEMBL 10.1016/j.bmcl.2003.12.053 10.7270/Q2VD6XV5 14980670 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140388&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44273702 104029977 CHEMBL20714 ZINC28233547 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027119 Cc1cc(C(=O)Nc2ccc(cc2F)-c2ccccc2S(C)(=O)=O)n(n1)-c1cc2ccccc2cc1S(C)(=O)=O InChI=1S/C29H24FN3O5S2/c1-18-14-26(33(32-18)25-16-19-8-4-5-9-20(19)17-28(25)40(3,37)38)29(34)31-24-13-12-21(15-23(24)30)22-10-6-7-11-27(22)39(2,35)36/h4-17H,1-3H3,(H,31,34) FXGWYXPHUQWSQF-UHFFFAOYSA-N 50140367 2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide::CHEMBL20604 Coagulation factor X Homo sapiens 1.7 ChEMBL 10.1016/j.bmcl.2003.12.053 10.7270/Q2VD6XV5 14980670 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140367&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20595260 104029956 CHEMBL20604 ZINC28234299 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027120 CN(C)Cc1ccccc1-c1ccc(NC(=O)c2cc(C)nn2-c2ccc3cc(Cl)ccc3c2)cc1 InChI=1S/C30H27ClN4O/c1-20-16-29(35(33-20)27-15-11-22-17-25(31)12-8-23(22)18-27)30(36)32-26-13-9-21(10-14-26)28-7-5-4-6-24(28)19-34(2)3/h4-18H,19H2,1-3H3,(H,32,36) VTIFDOBLLNTLSJ-UHFFFAOYSA-N 50140375 2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-dimethylaminomethyl-biphenyl-4-yl)-amide::CHEMBL20832 Coagulation factor X Homo sapiens 1.8 ChEMBL 10.1016/j.bmcl.2003.12.053 10.7270/Q2VD6XV5 14980670 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140375&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44274058 104029964 CHEMBL20832 ZINC28234415 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027122 Cc1cc(C(=O)Nc2ccc(cc2)-n2ccnc2C)n(n1)-c1ccc2cc(Cl)ccc2c1 InChI=1S/C25H20ClN5O/c1-16-13-24(31(29-16)23-8-4-18-14-20(26)5-3-19(18)15-23)25(32)28-21-6-9-22(10-7-21)30-12-11-27-17(30)2/h3-15H,1-2H3,(H,28,32) QNZWMYOSWTXTBZ-UHFFFAOYSA-N 50140352 2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid [4-(2-methyl-imidazol-1-yl)-phenyl]-amide::CHEMBL20603 Coagulation factor X Homo sapiens 8 ChEMBL 10.1016/j.bmcl.2003.12.053 10.7270/Q2VD6XV5 14980670 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140352&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44273645 104029941 CHEMBL20603 ZINC28233983 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027123 CN(C)Cc1nccn1-c1ccc(NC(=O)c2cc(C)nn2-c2cc3ccccc3cc2S(C)(=O)=O)c(F)c1 InChI=1S/C28H27FN6O3S/c1-18-13-25(35(32-18)24-14-19-7-5-6-8-20(19)15-26(24)39(4,37)38)28(36)31-23-10-9-21(16-22(23)29)34-12-11-30-27(34)17-33(2)3/h5-16H,17H2,1-4H3,(H,31,36) DPLRRZRCKVWXJJ-UHFFFAOYSA-N 50140401 2-(3-Methanesulfonyl-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid [4-(2-dimethylaminomethyl-imidazol-1-yl)-2-fluoro-phenyl]-amide::CHEMBL20561 Coagulation factor X Homo sapiens 8 ChEMBL 10.1016/j.bmcl.2003.12.053 10.7270/Q2VD6XV5 14980670 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140401&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44274011 104029990 CHEMBL20561 ZINC28237974 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027124 Cc1cc(C(=O)Nc2ccc(cc2F)-c2ccccc2S(C)(=O)=O)n(n1)-c1ccc2cc(Cl)ccc2c1 InChI=1S/C28H21ClFN3O3S/c1-17-13-26(33(32-17)22-11-8-18-14-21(29)10-7-19(18)15-22)28(34)31-25-12-9-20(16-24(25)30)23-5-3-4-6-27(23)37(2,35)36/h3-16H,1-2H3,(H,31,34) XMTZQCZYGBGKSJ-UHFFFAOYSA-N 50140356 2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide::CHEMBL20536 Coagulation factor X Homo sapiens 1.8 ChEMBL 10.1016/j.bmcl.2003.12.053 10.7270/Q2VD6XV5 14980670 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140356&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21366646 104029945 CHEMBL20536 ZINC28230576 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027125 Cc1cc(C(=O)Nc2ncc(cn2)-c2ccccc2S(N)(=O)=O)n(n1)-c1ccc2cc(Cl)ccc2c1 InChI=1S/C25H19ClN6O3S/c1-15-10-22(32(31-15)20-9-7-16-11-19(26)8-6-17(16)12-20)24(33)30-25-28-13-18(14-29-25)21-4-2-3-5-23(21)36(27,34)35/h2-14H,1H3,(H2,27,34,35)(H,28,29,30,33) NMJUJDCNPCHXBC-UHFFFAOYSA-N 50140381 2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyrimidin-2-yl]-amide::CHEMBL20299 Coagulation factor X Homo sapiens 7 ChEMBL 10.1016/j.bmcl.2003.12.053 10.7270/Q2VD6XV5 14980670 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140381&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44273493 104029970 CHEMBL20299 ZINC28229817 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027128 Cc1cc(C(=O)Nc2ccc(cn2)-c2ccccc2S(N)(=O)=O)n(n1)-c1ccc2cc(Cl)ccc2c1 InChI=1S/C26H20ClN5O3S/c1-16-12-23(32(31-16)21-10-7-17-13-20(27)9-6-18(17)14-21)26(33)30-25-11-8-19(15-29-25)22-4-2-3-5-24(22)36(28,34)35/h2-15H,1H3,(H2,28,34,35)(H,29,30,33) CPZVHEIHBOXGKU-UHFFFAOYSA-N 50140366 2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyridin-2-yl]-amide::CHEMBL277679 Coagulation factor X Homo sapiens 1.9 ChEMBL 10.1016/j.bmcl.2003.12.053 10.7270/Q2VD6XV5 14980670 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140366&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21366640 104029955 CHEMBL277679 ZINC28228803 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027129 Cc1cc(C(=O)Nc2ccc(cc2F)N2CCOCC2=O)n(n1)-c1cc2ccccc2cc1F InChI=1S/C25H20F2N4O3/c1-15-10-23(31(29-15)22-12-17-5-3-2-4-16(17)11-20(22)27)25(33)28-21-7-6-18(13-19(21)26)30-8-9-34-14-24(30)32/h2-7,10-13H,8-9,14H2,1H3,(H,28,33) RSFAKFNRGNVKNY-UHFFFAOYSA-N 50140371 2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid [2-fluoro-4-(3-oxo-morpholin-4-yl)-phenyl]-amide::CHEMBL21125 Coagulation factor X Homo sapiens 0.500000 ChEMBL 10.1016/j.bmcl.2003.12.053 10.7270/Q2VD6XV5 14980670 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140371&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44274046 104029960 CHEMBL21125 ZINC28235926 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027130 Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(C)(=O)=O)n(n1)-c1ccc2cc(Cl)ccc2c1 InChI=1S/C28H22ClN3O3S/c1-18-15-26(32(31-18)24-14-10-20-16-22(29)11-7-21(20)17-24)28(33)30-23-12-8-19(9-13-23)25-5-3-4-6-27(25)36(2,34)35/h3-17H,1-2H3,(H,30,33) HLHYXHNCGGCDMK-UHFFFAOYSA-N 50140377 2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-methanesulfonyl-biphenyl-4-yl)-amide::CHEMBL280696 Coagulation factor X Homo sapiens 4 ChEMBL 10.1016/j.bmcl.2003.12.053 10.7270/Q2VD6XV5 14980670 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Clizbe, LA; Goldman, EA; Sinha, U; Arfsten, AE; Edwards, ST; Alphonso, M; Hutchaleelaha, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140377&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21366636 104029966 CHEMBL280696 ZINC28233974 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027134 Fc1cc(ccc1NC(=O)c1cc(nn1-c1cc2ccccc2cc1F)C(F)(F)F)C(=N)N1CCCC1 InChI=1S/C26H20F5N5O/c27-18-12-17(24(32)35-9-3-4-10-35)7-8-20(18)33-25(37)22-14-23(26(29,30)31)34-36(22)21-13-16-6-2-1-5-15(16)11-19(21)28/h1-2,5-8,11-14,32H,3-4,9-10H2,(H,33,37) WNEFIHZOWXDTPA-UHFFFAOYSA-N 50404324 CHEMBL2092985 Coagulation factor X Homo sapiens 10 ChEMBL 10.1016/j.bmcl.2003.12.054 10.7270/Q2QN6664 14980671 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Song, Y; Woolfrey, J; Sinha, U; Arfsten, AE; Edwards, ST; Hutchaleelaha, A; Hollennbach, SJ; Lambing, JL; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50404324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50404324&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21366563 163353348 CHEMBL2092985 ZINC84708848 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027136 Cc1cc(C(=O)Nc2ccc(cc2F)C(=N)N2CCCCC2)n(n1)-c1cc2ccccc2cc1F InChI=1S/C27H25F2N5O/c1-17-13-25(34(32-17)24-16-19-8-4-3-7-18(19)14-22(24)29)27(35)31-23-10-9-20(15-21(23)28)26(30)33-11-5-2-6-12-33/h3-4,7-10,13-16,30H,2,5-6,11-12H2,1H3,(H,31,35) DYJHCTNNQAYHCI-UHFFFAOYSA-N 50140427 2-(3-Fluoro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid [2-fluoro-4-(imino-piperidin-1-yl-methyl)-phenyl]-amide::CHEMBL20897 Coagulation factor X Homo sapiens 8 ChEMBL 10.1016/j.bmcl.2003.12.054 10.7270/Q2QN6664 14980671 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Song, Y; Woolfrey, J; Sinha, U; Arfsten, AE; Edwards, ST; Hutchaleelaha, A; Hollennbach, SJ; Lambing, JL; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140427&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21366560 104030016 CHEMBL20897 ZINC28235294 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027137 CN(C)C(=N)c1ccc(NC(=O)c2nnnn2-c2ccc3cc(Cl)ccc3c2)c(F)c1 InChI=1S/C21H17ClFN7O/c1-29(2)19(24)14-5-8-18(17(23)11-14)25-21(31)20-26-27-28-30(20)16-7-4-12-9-15(22)6-3-13(12)10-16/h3-11,24H,1-2H3,(H,25,31) SORXSNFJTDQXLI-UHFFFAOYSA-N 50140443 1-(6-Chloro-naphthalen-2-yl)-1H-tetrazole-5-carboxylic acid [4-(N,N-dimethyl-carbamimidoyl)-2-fluoro-phenyl]-amide::CHEMBL21250 Coagulation factor X Homo sapiens 0.700000 ChEMBL 10.1016/j.bmcl.2003.12.054 10.7270/Q2QN6664 14980671 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Song, Y; Woolfrey, J; Sinha, U; Arfsten, AE; Edwards, ST; Hutchaleelaha, A; Hollennbach, SJ; Lambing, JL; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140443&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21366482 104030032 CHEMBL21250 ZINC28231471 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50027143 CN(C)C(=N)c1ccc(NC(=O)c2cc(C)nn2-c2ccc3cc(Cl)ccc3c2)c(F)c1 InChI=1S/C24H21ClFN5O/c1-14-10-22(24(32)28-21-9-6-17(13-20(21)26)23(27)30(2)3)31(29-14)19-8-5-15-11-18(25)7-4-16(15)12-19/h4-13,27H,1-3H3,(H,28,32) MMSOCXBFSNEWLT-UHFFFAOYSA-N 50140424 2-(6-Chloro-naphthalen-2-yl)-5-methyl-2H-pyrazole-3-carboxylic acid [4-(N,N-dimethyl-carbamimidoyl)-2-fluoro-phenyl]-amide::CHEMBL20918 Coagulation factor X Homo sapiens 5 ChEMBL 10.1016/j.bmcl.2003.12.054 10.7270/Q2QN6664 14980671 Jia, ZJ; Wu, Y; Huang, W; Zhang, P; Song, Y; Woolfrey, J; Sinha, U; Arfsten, AE; Edwards, ST; Hutchaleelaha, A; Hollennbach, SJ; Lambing, JL; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140424&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10389039 104030013 CHEMBL20918 ZINC03949174 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50023000 CO[C@H]1O[C@H](COS(O)(=O)=O)[C@@H](O[C@@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COS(O)(=O)=O)[C@@H](O)[C@H](O)[C@H]3NS(O)(=O)=O)[C@H](O)[C@H]2O)C(O)=O)[C@H](OS(O)(=O)=O)[C@H]1NS(O)(=O)=O InChI=1S/C19H34N2O30S5/c1-43-17-7(21-53(31,32)33)13(51-56(40,41)42)12(5(47-17)3-45-55(37,38)39)48-19-11(25)10(24)14(15(50-19)16(26)27)49-18-6(20-52(28,29)30)9(23)8(22)4(46-18)2-44-54(34,35)36/h4-15,17-25H,2-3H2,1H3,(H,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36)(H,37,38,39)(H,40,41,42)/t4-,5-,6-,7-,8-,9-,10-,11-,12-,13-,14+,15+,17+,18-,19-/m1/s1 XTOSKUWVIRIKJD-LUQVCBTISA-N 50421638 CHEMBL2303825 Coagulation factor X Homo sapiens 2000 ChEMBL 10.1016/s0960-894x(02)01055-7 10.7270/Q20865VX 12639557 Gunnarsson, GT; Desai, UR Virginia Commonwealth University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50421638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50421638&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71720265 164150513 CHEMBL2303825 C01614 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50023001 CO[C@@H]1O[C@H]([C@@H](O[C@H]2OC(COS(O)(=O)=O)=C[C@H](OS(O)(=O)=O)[C@H]2NS(O)(=O)=O)[C@H](O)[C@H]1OS(O)(=O)=O)C(O)=O InChI=1S/C13H21NO22S4/c1-30-13-9(36-40(27,28)29)7(15)8(10(34-13)11(16)17)33-12-6(14-37(18,19)20)5(35-39(24,25)26)2-4(32-12)3-31-38(21,22)23/h2,5-10,12-15H,3H2,1H3,(H,16,17)(H,18,19,20)(H,21,22,23)(H,24,25,26)(H,27,28,29)/t5-,6+,7-,8-,9+,10+,12+,13+/m0/s1 IPQPDAVGKFYCKY-MGPPVRRBSA-N 50421637 CHEMBL2303826 Coagulation factor X Homo sapiens 95000 ChEMBL 10.1016/s0960-894x(02)01055-7 10.7270/Q20865VX 12639557 Gunnarsson, GT; Desai, UR Virginia Commonwealth University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50421637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50421637&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 71719662 164150512 CHEMBL2303826 C01614 ZINC95564579 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50023185 NC(=N)NCCCC(NC(=O)CN1CCN(CC1=O)S(=O)(=O)c1ccc2c(Cl)cccc2c1)C(=O)c1nccs1 InChI=1S/C25H28ClN7O5S2/c26-19-4-1-3-16-13-17(6-7-18(16)19)40(37,38)33-11-10-32(22(35)15-33)14-21(34)31-20(5-2-8-30-25(27)28)23(36)24-29-9-12-39-24/h1,3-4,6-7,9,12-13,20H,2,5,8,10-11,14-15H2,(H,31,34)(H4,27,28,30) LCSPIPBAMWVNCU-UHFFFAOYSA-N 50124979 2-[4-(5-Chloro-naphthalene-2-sulfonyl)-2-oxo-piperazin-1-yl]-N-[4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide::CHEMBL350587 Coagulation factor X Homo sapiens 0.790000 ChEMBL 10.1016/s0960-894x(02)01037-5 10.7270/Q2Z037JH 12639567 Huang, W; Naughton, MA; Yang, H; Su, T; Dam, S; Wong, PW; Arfsten, A; Edwards, S; Sinha, U; Hollenbach, S; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50124979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50124979&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44376252 104017229 CHEMBL350587 ZINC27843684 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50023186 NC(=N)NCCCC(NC(=O)CN1CCN(CC1=O)S(=O)(=O)c1ccc2ccccc2c1)C(=O)c1nccs1 InChI=1S/C25H29N7O5S2/c26-25(27)29-9-3-6-20(23(35)24-28-10-13-38-24)30-21(33)15-31-11-12-32(16-22(31)34)39(36,37)19-8-7-17-4-1-2-5-18(17)14-19/h1-2,4-5,7-8,10,13-14,20H,3,6,9,11-12,15-16H2,(H,30,33)(H4,26,27,29) LGGUFBYXMLCOMY-UHFFFAOYSA-N 50124972 CHEMBL163174::N-[4-Guanidino-1-(thiazole-2-carbonyl)-butyl]-2-[4-(naphthalene-2-sulfonyl)-2-oxo-piperazin-1-yl]-acetamide Coagulation factor X Homo sapiens 8 ChEMBL 10.1016/s0960-894x(02)01037-5 10.7270/Q2Z037JH 12639567 Huang, W; Naughton, MA; Yang, H; Su, T; Dam, S; Wong, PW; Arfsten, A; Edwards, S; Sinha, U; Hollenbach, S; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50124972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50124972&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20641745 104017222 CHEMBL163174 ZINC04423861 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50023190 NC(=N)NCCC[C@@H](NC(=O)CN1CCN(CC1=O)S(=O)(=O)c1ccc(Cl)cc1)C(=O)c1nccs1 InChI=1S/C21H26ClN7O5S2/c22-14-3-5-15(6-4-14)36(33,34)29-10-9-28(18(31)13-29)12-17(30)27-16(2-1-7-26-21(23)24)19(32)20-25-8-11-35-20/h3-6,8,11,16H,1-2,7,9-10,12-13H2,(H,27,30)(H4,23,24,26)/t16-/m1/s1 RCRCIDZJGYMMJX-MRXNPFEDSA-N 50124995 2-[4-(4-Chloro-benzenesulfonyl)-2-oxo-piperazin-1-yl]-N-[(R)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-acetamide::CHEMBL159695 Coagulation factor X Homo sapiens 2 ChEMBL 10.1016/s0960-894x(02)01037-5 10.7270/Q2Z037JH 12639567 Huang, W; Naughton, MA; Yang, H; Su, T; Dam, S; Wong, PW; Arfsten, A; Edwards, S; Sinha, U; Hollenbach, S; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50124995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50124995&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44376100 104017245 CHEMBL159695 ZINC27755451 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50023197 NC(=N)NCCC[C@@H](NS(=O)(=O)Cc1ccccc1)C(=O)NCC(=O)N[C@H](CCCNC(N)=N)C(=O)c1nccs1 InChI=1S/C24H36N10O5S2/c25-23(26)30-10-4-8-17(20(36)22-29-12-13-40-22)33-19(35)14-32-21(37)18(9-5-11-31-24(27)28)34-41(38,39)15-16-6-2-1-3-7-16/h1-3,6-7,12-13,17-18,34H,4-5,8-11,14-15H2,(H,32,37)(H,33,35)(H4,25,26,30)(H4,27,28,31)/t17-,18-/m1/s1 BZGZTAKGLPGMAV-QZTJIDSGSA-N 50124984 (R)-5-Guanidino-2-phenylmethanesulfonylamino-pentanoic acid {[(R)-4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-methyl}-amide::CHEMBL352039 Coagulation factor X Homo sapiens 0.000007 3.1 ChEMBL 10.1016/s0960-894x(02)01037-5 10.7270/Q2Z037JH 12639567 Huang, W; Naughton, MA; Yang, H; Su, T; Dam, S; Wong, PW; Arfsten, A; Edwards, S; Sinha, U; Hollenbach, S; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50124984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50124984&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44375987 104017234 CHEMBL352039 ZINC27751390 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028363 COc1c(Br)cc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H28BrCl2N3O3/c1-35-26-23(28)14-20(15-25(26)36-13-8-19-2-3-21(29)16-24(19)30)27(34)32-17-18-6-11-33(12-7-18)22-4-9-31-10-5-22/h2-5,9-10,14-16,18H,6-8,11-13,17H2,1H3,(H,32,34) BDYFOSDTBNSZBW-UHFFFAOYSA-N 13661 3-Oxybenzamide 47::3-bromo-5-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 1053 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13661&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646475 46514053 ZINC14953536 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028364 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(Cc2ccncc2)CC1 InChI=1S/C28H31Cl2N3O3/c1-35-26-5-3-23(16-27(26)36-15-10-22-2-4-24(29)17-25(22)30)28(34)32-18-20-8-13-33(14-9-20)19-21-6-11-31-12-7-21/h2-7,11-12,16-17,20H,8-10,13-15,18-19H2,1H3,(H,32,34) DFOLWHGZUDJOTI-UHFFFAOYSA-N 13679 3-Oxybenzamide 65::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(pyridin-4-ylmethyl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 970 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13679&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11398411 46514070 ZINC13643423 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028365 COc1ccc(cc1OCCc1ccc(Cl)cc1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H30ClN3O3/c1-33-25-7-4-22(18-26(25)34-17-12-20-2-5-23(28)6-3-20)27(32)30-19-21-10-15-31(16-11-21)24-8-13-29-14-9-24/h2-9,13-14,18,21H,10-12,15-17,19H2,1H3,(H,30,32) IHWQZDBTWMPDIP-UHFFFAOYSA-N 13665 3-Oxybenzamide 51::3-[2-(4-chlorophenyl)ethoxy]-4-methoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 41 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13665&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396258 46514057 ZINC13643401 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028366 Fc1ccc(cc1OCCc1ccc(cc1)C#N)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H27FN4O2/c28-25-6-5-23(17-26(25)34-16-11-20-1-3-21(18-29)4-2-20)27(33)31-19-22-9-14-32(15-10-22)24-7-12-30-13-8-24/h1-8,12-13,17,22H,9-11,14-16,19H2,(H,31,33) MWAZJUSHGPEJEM-UHFFFAOYSA-N 13633 3-Oxybenzamide 19::3-[2-(4-cyanophenyl)ethoxy]-4-fluoro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 4605 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13633&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396259 46514025 ZINC13643369 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028367 Cc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H29Cl2N3O2/c1-19-2-3-22(16-26(19)34-15-10-21-4-5-23(28)17-25(21)29)27(33)31-18-20-8-13-32(14-9-20)24-6-11-30-12-7-24/h2-7,11-12,16-17,20H,8-10,13-15,18H2,1H3,(H,31,33) QPHKHBUNEICWPT-UHFFFAOYSA-N 13642 3-Oxybenzamide 28::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methyl-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 37 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13642&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396230 46514034 ZINC03989404 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028368 Fc1ccc(cc1OCCc1ccc(Cl)cc1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C26H27ClFN3O2/c27-22-4-1-19(2-5-22)11-16-33-25-17-21(3-6-24(25)28)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18H2,(H,30,32) SPSKAYMQPXKPMJ-UHFFFAOYSA-N 13617 3-Oxybenzamide 3::3-[2-(4-chlorophenyl)ethoxy]-4-fluoro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13617&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052371 46514009 ZINC13643337 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028369 NC(=O)c1cc(OCCc2ccc(Cl)cc2Cl)cc(c1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H28Cl2N4O3/c28-22-2-1-19(25(29)16-22)7-12-36-24-14-20(26(30)34)13-21(15-24)27(35)32-17-18-5-10-33(11-6-18)23-3-8-31-9-4-23/h1-4,8-9,13-16,18H,5-7,10-12,17H2,(H2,30,34)(H,32,35) ZKSQIMPBUMVRHT-UHFFFAOYSA-N 13651 3-Oxybenzamide 37::5-[2-(2,4-dichlorophenyl)ethoxy]-1-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzene-1,3-dicarboxamide Coagulation factor X Homo sapiens 51 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13651&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10052619 46514043 ZINC13643389 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028370 COc1ccc(CCOc2cc(ccc2F)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C27H30FN3O3/c1-33-24-5-2-20(3-6-24)12-17-34-26-18-22(4-7-25(26)28)27(32)30-19-21-10-15-31(16-11-21)23-8-13-29-14-9-23/h2-9,13-14,18,21H,10-12,15-17,19H2,1H3,(H,30,32) SUDGKHGTKKJQCF-UHFFFAOYSA-N 13632 3-Oxybenzamide 18::4-fluoro-3-[2-(4-methoxyphenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 307 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13632&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396291 46514024 ZINC13643367 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028371 CSc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H29Cl2N3O2S/c1-35-26-5-3-21(16-25(26)34-15-10-20-2-4-22(28)17-24(20)29)27(33)31-18-19-8-13-32(14-9-19)23-6-11-30-12-7-23/h2-7,11-12,16-17,19H,8-10,13-15,18H2,1H3,(H,31,33) BCQQWWXAOHPASE-UHFFFAOYSA-N 13652 3-Oxybenzamide 38::3-[2-(2,4-dichlorophenyl)ethoxy]-4-(methylsulfanyl)-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 28 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13652&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052452 46514044 ZINC03989406 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028372 COc1cc(cc(OCCc2ccc(Cl)cc2Cl)c1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H28Cl3N3O3/c1-35-24-14-20(15-25(26(24)30)36-13-8-19-2-3-21(28)16-23(19)29)27(34)32-17-18-6-11-33(12-7-18)22-4-9-31-10-5-22/h2-5,9-10,14-16,18H,6-8,11-13,17H2,1H3,(H,32,34) VPVZSERFJANUOF-UHFFFAOYSA-N 13662 3-Oxybenzamide 48::4-chloro-3-[2-(2,4-dichlorophenyl)ethoxy]-5-methoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 10.0 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13662&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9937410 46514054 ZINC14953541 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028373 CC(=O)Nc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C28H30Cl2N4O3/c1-19(35)33-26-5-3-22(16-27(26)37-15-10-21-2-4-23(29)17-25(21)30)28(36)32-18-20-8-13-34(14-9-20)24-6-11-31-12-7-24/h2-7,11-12,16-17,20H,8-10,13-15,18H2,1H3,(H,32,36)(H,33,35) NDDNITDSHULYDX-UHFFFAOYSA-N 13648 3-Oxybenzamide 34::3-[2-(2,4-dichlorophenyl)ethoxy]-4-acetamido-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 316 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13648&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052326 46514040 ZINC14953497 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028374 Clc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)c(Cl)c1 InChI=1S/C26H26Cl3N3O2/c27-21-3-1-19(24(29)16-21)9-14-34-25-15-20(2-4-23(25)28)26(33)31-17-18-7-12-32(13-8-18)22-5-10-30-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17H2,(H,31,33) OJUQZWAQJCEVIB-UHFFFAOYSA-N 13667 3-Oxybenzamide 53::4-chloro-3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 41 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13667&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052482 46514059 ZINC13643405 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028375 NC(=O)Nc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H29Cl2N5O3/c28-21-3-1-19(23(29)16-21)9-14-37-25-15-20(2-4-24(25)33-27(30)36)26(35)32-17-18-7-12-34(13-8-18)22-5-10-31-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17H2,(H,32,35)(H3,30,33,36) PZTVPHNZFYDIEQ-UHFFFAOYSA-N 13649 3-Oxybenzamide 35::4-(carbamoylamino)-3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 1763 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13649&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052377 46514041 ZINC14953503 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028376 Clc1cccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)c1 InChI=1S/C26H27Cl2N3O2/c27-22-3-1-2-19(16-22)10-15-33-25-17-21(4-5-24(25)28)26(32)30-18-20-8-13-31(14-9-20)23-6-11-29-12-7-23/h1-7,11-12,16-17,20H,8-10,13-15,18H2,(H,30,32) XKBUEUQVUBZXMJ-UHFFFAOYSA-N 13624 3-Oxybenzamide 10::4-chloro-3-[2-(3-chlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 1931 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13624&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396282 46514016 ZINC13643351 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028377 CC(C)Oc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C29H33Cl2N3O3/c1-20(2)37-27-6-4-23(17-28(27)36-16-11-22-3-5-24(30)18-26(22)31)29(35)33-19-21-9-14-34(15-10-21)25-7-12-32-13-8-25/h3-8,12-13,17-18,20-21H,9-11,14-16,19H2,1-2H3,(H,33,35) OCXDHMHFDLCZGZ-UHFFFAOYSA-N 13654 3-Oxybenzamide 40::3-[2-(2,4-dichlorophenyl)ethoxy]-4-(propan-2-yloxy)-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 233 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13654&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052392 46514046 ZINC14953509 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028378 CCOc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C28H31Cl2N3O3/c1-2-35-26-6-4-22(17-27(26)36-16-11-21-3-5-23(29)18-25(21)30)28(34)32-19-20-9-14-33(15-10-20)24-7-12-31-13-8-24/h3-8,12-13,17-18,20H,2,9-11,14-16,19H2,1H3,(H,32,34) ZXKUYRLODOJGJS-UHFFFAOYSA-N 13653 3-Oxybenzamide 39::3-[2-(2,4-dichlorophenyl)ethoxy]-4-ethoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 61 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13653&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052325 46514045 ZINC13643392 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028379 Nc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C26H28Cl2N4O2/c27-21-3-1-19(23(28)16-21)9-14-34-25-15-20(2-4-24(25)29)26(33)31-17-18-7-12-32(13-8-18)22-5-10-30-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17,29H2,(H,31,33) USTDQHUKYVFTSB-UHFFFAOYSA-N 13645 3-Oxybenzamide 31::4-amino-3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 29 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13645&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052320 46514037 ZINC00596623 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028380 CNc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H30Cl2N4O2/c1-30-25-5-3-21(16-26(25)35-15-10-20-2-4-22(28)17-24(20)29)27(34)32-18-19-8-13-33(14-9-19)23-6-11-31-12-7-23/h2-7,11-12,16-17,19,30H,8-10,13-15,18H2,1H3,(H,32,34) XWSIHPCRYGDRLR-UHFFFAOYSA-N 13646 3-Oxybenzamide 32::3-[2-(2,4-dichlorophenyl)ethoxy]-4-(methylamino)-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 48 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13646&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052309 46514038 ZINC13643383 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028381 Clc1ccc(CCOc2cc(ccc2Br)C(=O)NCC2CCN(CC2)c2ccncc2)c(Cl)c1 InChI=1S/C26H26BrCl2N3O2/c27-23-4-2-20(15-25(23)34-14-9-19-1-3-21(28)16-24(19)29)26(33)31-17-18-7-12-32(13-8-18)22-5-10-30-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17H2,(H,31,33) ADLCQQQYJWNTLY-UHFFFAOYSA-N 13640 3-Oxybenzamide 26::4-bromo-3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 76 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13640&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052436 46514032 ZINC14953480 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028382 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)N1CCN(Cc2ccncc2)CC1 InChI=1S/C26H27Cl2N3O3/c1-33-24-5-3-21(16-25(24)34-15-8-20-2-4-22(27)17-23(20)28)26(32)31-13-11-30(12-14-31)18-19-6-9-29-10-7-19/h2-7,9-10,16-17H,8,11-15,18H2,1H3 SOJUZKVZNHWTCE-UHFFFAOYSA-N 13676 1-({3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxyphenyl}carbonyl)-4-(pyridin-4-ylmethyl)piperazine::3-Oxybenzamide 62 Coagulation factor X Homo sapiens 600 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13676&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10185372 46514067 ZINC13643417 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028383 CC(=O)Nc1ccc(COc2cc(ccc2F)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C27H29FN4O3/c1-19(33)31-23-5-2-21(3-6-23)18-35-26-16-22(4-7-25(26)28)27(34)30-17-20-10-14-32(15-11-20)24-8-12-29-13-9-24/h2-9,12-13,16,20H,10-11,14-15,17-18H2,1H3,(H,30,34)(H,31,33) ABUNJKGQVMIKAO-UHFFFAOYSA-N 50452116 CHEMBL97678 Coagulation factor X Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50452116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50452116&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396266 225145582 CHEMBL97678 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028384 Fc1ccc(cc1OCCc1ccc(Br)cc1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C26H27BrFN3O2/c27-22-4-1-19(2-5-22)11-16-33-25-17-21(3-6-24(25)28)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18H2,(H,30,32) KREFHLJLUUEHNH-UHFFFAOYSA-N 13629 3-Oxybenzamide 15::3-[2-(4-bromophenyl)ethoxy]-4-fluoro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 71 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13629&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396256 46514021 ZINC13643359 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028385 Fc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C26H26Cl2FN3O2/c27-21-3-1-19(23(28)16-21)9-14-34-25-15-20(2-4-24(25)29)26(33)31-17-18-7-12-32(13-8-18)22-5-10-30-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17H2,(H,31,33) WKMDLCMGKOYKFG-UHFFFAOYSA-N 13616 3-Oxybenzamide 2::3-[2-(2,4-dichlorophenyl)ethoxy]-4-fluoro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 50 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13616&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396199 46514008 ZINC13643334 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028386 Clc1ccc(CCOc2cc(ccc2NC=O)C(=O)NCC2CCN(CC2)c2ccncc2)c(Cl)c1 InChI=1S/C27H28Cl2N4O3/c28-22-3-1-20(24(29)16-22)9-14-36-26-15-21(2-4-25(26)32-18-34)27(35)31-17-19-7-12-33(13-8-19)23-5-10-30-11-6-23/h1-6,10-11,15-16,18-19H,7-9,12-14,17H2,(H,31,35)(H,32,34) PAURWMOEDJATQA-UHFFFAOYSA-N 13647 3-Oxybenzamide 33::3-[2-(2,4-dichlorophenyl)ethoxy]-1-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzene-1,4-dicarboxamide Coagulation factor X Homo sapiens 75 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13647&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052484 46514039 C06049 ZINC13643385 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028387 COc1cc(cc(OCCc2ccc(Cl)cc2Cl)c1C)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C28H31Cl2N3O3/c1-19-26(35-2)15-22(16-27(19)36-14-9-21-3-4-23(29)17-25(21)30)28(34)32-18-20-7-12-33(13-8-20)24-5-10-31-11-6-24/h3-6,10-11,15-17,20H,7-9,12-14,18H2,1-2H3,(H,32,34) CRHWKPQYKCDTLK-UHFFFAOYSA-N 13663 3-Oxybenzamide 49::3-[2-(2,4-dichlorophenyl)ethoxy]-5-methoxy-4-methyl-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13663&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052323 46514055 ZINC13643396 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028388 Fc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C26H27ClFN3O2/c27-24-6-3-21(17-25(24)33-16-11-19-1-4-22(28)5-2-19)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18H2,(H,30,32) CKSYIUHRYUDSQE-UHFFFAOYSA-N 13620 3-Oxybenzamide 6::4-chloro-3-[2-(4-fluorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 102 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13620&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396287 46514012 ZINC13643341 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028389 Clc1ccc(cc1OCCc1ccc(cc1)C#N)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H27ClN4O2/c28-25-6-5-23(17-26(25)34-16-11-20-1-3-21(18-29)4-2-20)27(33)31-19-22-9-14-32(15-10-22)24-7-12-30-13-8-24/h1-8,12-13,17,22H,9-11,14-16,19H2,(H,31,33) GTHTVLJAXOPDRK-UHFFFAOYSA-N 13623 3-Oxybenzamide 9::4-chloro-3-[2-(4-cyanophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 1552 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13623&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396286 46514015 ZINC13643349 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028390 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccnc(Cl)n1 InChI=1S/C26H27Cl3N4O3/c1-35-22-5-3-19(14-23(22)36-13-9-18-2-4-20(27)15-21(18)28)25(34)31-16-17-7-11-33(12-8-17)24-6-10-30-26(29)32-24/h2-6,10,14-15,17H,7-9,11-13,16H2,1H3,(H,31,34) SYORKTQWURASHM-UHFFFAOYSA-N 13675 3-Oxybenzamide 61::N-{[1-(2-chloropyrimidin-4-yl)piperidin-4-yl]methyl}-3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxybenzamide Coagulation factor X Homo sapiens 264 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13675&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11249816 46514066 ZINC14953556 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028391 Clc1ccc(CCOc2cccc(c2)C(=O)NCC2CCN(CC2)c2ccncc2)c(Cl)c1 InChI=1S/C26H27Cl2N3O2/c27-22-5-4-20(25(28)17-22)10-15-33-24-3-1-2-21(16-24)26(32)30-18-19-8-13-31(14-9-19)23-6-11-29-12-7-23/h1-7,11-12,16-17,19H,8-10,13-15,18H2,(H,30,32) AQDTWVBZQDZQEZ-UHFFFAOYSA-N 13639 3-Oxybenzamide 25::3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 106 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13639&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052368 46514031 ZINC13643379 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028392 CC(C)(C)OC(=O)Nc1ccc(CCOc2cc(ccc2F)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C31H37FN4O4/c1-31(2,3)40-30(38)35-25-7-4-22(5-8-25)14-19-39-28-20-24(6-9-27(28)32)29(37)34-21-23-12-17-36(18-13-23)26-10-15-33-16-11-26/h4-11,15-16,20,23H,12-14,17-19,21H2,1-3H3,(H,34,37)(H,35,38) QXLYGSVBJIHLCV-UHFFFAOYSA-N 13637 3-Oxybenzamide 23::tert-butyl N-(4-{2-[2-fluoro-5-({[1-(pyridin-4-yl)piperidin-4-yl]methyl}carbamoyl)phenoxy]ethyl}phenyl)carbamate Coagulation factor X Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13637&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396328 46514029 ZINC14953474 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028393 CCOc1cc(cc(OCCc2ccc(Cl)cc2Cl)c1OCC)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C30H35Cl2N3O4/c1-3-37-27-17-23(30(36)34-20-21-9-14-35(15-10-21)25-7-12-33-13-8-25)18-28(29(27)38-4-2)39-16-11-22-5-6-24(31)19-26(22)32/h5-8,12-13,17-19,21H,3-4,9-11,14-16,20H2,1-2H3,(H,34,36) APMZHDGXRDMALH-UHFFFAOYSA-N 13657 3-Oxybenzamide 43::3-[2-(2,4-dichlorophenyl)ethoxy]-4,5-diethoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 263 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13657&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052419 46514049 ZINC14953519 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028394 CC(C)(C)OC(=O)Nc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C31H37ClN4O4/c1-31(2,3)40-30(38)35-25-7-4-22(5-8-25)14-19-39-28-20-24(6-9-27(28)32)29(37)34-21-23-12-17-36(18-13-23)26-10-15-33-16-11-26/h4-11,15-16,20,23H,12-14,17-19,21H2,1-3H3,(H,34,37)(H,35,38) JIBPEZNZJOOEKR-UHFFFAOYSA-N 13627 3-Oxybenzamide 13::tert-butyl N-(4-{2-[2-chloro-5-({[1-(pyridin-4-yl)piperidin-4-yl]methyl}carbamoyl)phenoxy]ethyl}phenyl)carbamate Coagulation factor X Homo sapiens 4531 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13627&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396327 46514019 ZINC14953469 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028395 Cc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C27H30ClN3O2/c1-20-2-4-21(5-3-20)12-17-33-26-18-23(6-7-25(26)28)27(32)30-19-22-10-15-31(16-11-22)24-8-13-29-14-9-24/h2-9,13-14,18,22H,10-12,15-17,19H2,1H3,(H,30,32) MYMXDIMTTAYBBP-UHFFFAOYSA-N 13621 3-Oxybenzamide 7::4-chloro-3-[2-(4-methylphenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 124 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13621&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396288 46514013 ZINC13643344 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028396 Clc1ccc(cc1OCCc1ccc(Br)cc1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C26H27BrClN3O2/c27-22-4-1-19(2-5-22)11-16-33-25-17-21(3-6-24(25)28)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18H2,(H,30,32) MNIIBNMCMGLNIR-UHFFFAOYSA-N 13619 3-Oxybenzamide 5::3-[2-(4-bromophenyl)ethoxy]-4-chloro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 36 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13619&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396255 46514011 ZINC14953463 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028397 Clc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)nc1 InChI=1S/C25H26Cl2N4O2/c26-20-2-3-21(29-17-20)9-14-33-24-15-19(1-4-23(24)27)25(32)30-16-18-7-12-31(13-8-18)22-5-10-28-11-6-22/h1-6,10-11,15,17-18H,7-9,12-14,16H2,(H,30,32) AKPBXRZTJLYEEN-UHFFFAOYSA-N 13615 3-Oxybenzamide 1::4-chloro-3-[2-(5-chloropyridin-2-yl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13615&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052426 46514007 ZINC13643332 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028398 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H29Cl2N3O3/c1-34-25-5-3-21(16-26(25)35-15-10-20-2-4-22(28)17-24(20)29)27(33)31-18-19-8-13-32(14-9-19)23-6-11-30-12-7-23/h2-7,11-12,16-17,19H,8-10,13-15,18H2,1H3,(H,31,33) UVSAHJWEJXWVGO-UHFFFAOYSA-N 13664 3-Oxybenzamide 50::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 18 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13664&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search I1H 2BMG 6420136 46514056 ZINC13643398 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028399 CC(=O)Nc1ccc(COc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C27H29ClN4O3/c1-19(33)31-23-5-2-21(3-6-23)18-35-26-16-22(4-7-25(26)28)27(34)30-17-20-10-14-32(15-11-20)24-8-12-29-13-9-24/h2-9,12-13,16,20H,10-11,14-15,17-18H2,1H3,(H,30,34)(H,31,33) ZTECLPHQQJZLLA-UHFFFAOYSA-N 50452117 CHEMBL97341 Coagulation factor X Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50452117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50452117&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396265 225145583 CHEMBL97341 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028400 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncn1 InChI=1S/C26H28Cl2N4O3/c1-34-23-5-3-20(14-24(23)35-13-9-19-2-4-21(27)15-22(19)28)26(33)30-16-18-7-11-32(12-8-18)25-6-10-29-17-31-25/h2-6,10,14-15,17-18H,7-9,11-13,16H2,1H3,(H,30,33) YNZXWKUWGMCJGP-UHFFFAOYSA-N 13674 3-Oxybenzamide 60::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(pyrimidin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 110 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13674&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11156562 46514065 ZINC13643415 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028401 COc1cccc(CCOc2cc(ccc2F)C(=O)NCC2CCN(CC2)c2ccncc2)c1 InChI=1S/C27H30FN3O3/c1-33-24-4-2-3-20(17-24)11-16-34-26-18-22(5-6-25(26)28)27(32)30-19-21-9-14-31(15-10-21)23-7-12-29-13-8-23/h2-8,12-13,17-18,21H,9-11,14-16,19H2,1H3,(H,30,32) WLNFMTABODWTMD-UHFFFAOYSA-N 13635 3-Oxybenzamide 21::4-fluoro-3-[2-(3-methoxyphenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 3348 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13635&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396289 46514027 ZINC13643375 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028402 Nc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C26H29ClN4O2/c27-24-6-3-21(17-25(24)33-16-11-19-1-4-22(28)5-2-19)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18,28H2,(H,30,32) CVUVHSMJDWAULJ-UHFFFAOYSA-N 13626 3-Oxybenzamide 12::3-[2-(4-aminophenyl)ethoxy]-4-chloro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 420 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13626&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052453 46514018 ZINC13643355 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028403 Fc1ccc(cc1OCCc1cccc(Cl)c1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C26H27ClFN3O2/c27-22-3-1-2-19(16-22)10-15-33-25-17-21(4-5-24(25)28)26(32)30-18-20-8-13-31(14-9-20)23-6-11-29-12-7-23/h1-7,11-12,16-17,20H,8-10,13-15,18H2,(H,30,32) RHJHCDDSINXMPN-UHFFFAOYSA-N 13634 3-Oxybenzamide 20::3-[2-(3-chlorophenyl)ethoxy]-4-fluoro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 712 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13634&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396254 46514026 ZINC13643373 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028404 NC(=O)c1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H28Cl2N4O3/c28-21-3-1-19(24(29)16-21)9-14-36-25-15-20(2-4-23(25)26(30)34)27(35)32-17-18-7-12-33(13-8-18)22-5-10-31-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17H2,(H2,30,34)(H,32,35) RAVOKSWRPDYRAE-UHFFFAOYSA-N 13650 3-Oxybenzamide 36::3-[2-(2,4-dichlorophenyl)ethoxy]-1-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzene-1,4-dicarboxamide Coagulation factor X Homo sapiens 588 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13650&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396194 46514042 ZINC13643387 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028405 Fc1ccc(cc1OCCc1ccc(Cl)cn1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C25H26ClFN4O2/c26-20-2-3-21(29-17-20)9-14-33-24-15-19(1-4-23(24)27)25(32)30-16-18-7-12-31(13-8-18)22-5-10-28-11-6-22/h1-6,10-11,15,17-18H,7-9,12-14,16H2,(H,30,32) LTHCKUVKEGEEGL-UHFFFAOYSA-N 13618 3-Oxybenzamide 4::3-[2-(5-chloropyridin-2-yl)ethoxy]-4-fluoro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 37 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13618&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052373 46514010 ZINC13643339 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028406 Nc1ccc(CCOc2cc(ccc2F)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C26H29FN4O2/c27-24-6-3-21(17-25(24)33-16-11-19-1-4-22(28)5-2-19)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18,28H2,(H,30,32) USYBQIBCQASYJA-UHFFFAOYSA-N 13636 3-Oxybenzamide 22::3-[2-(4-aminophenyl)ethoxy]-4-fluoro-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 1554 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13636&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052465 46514028 ZINC12355245 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028407 Clc1ccc(CCOc2cc(ccc2I)C(=O)NCC2CCN(CC2)c2ccncc2)c(Cl)c1 InChI=1S/C26H26Cl2IN3O2/c27-21-3-1-19(23(28)16-21)9-14-34-25-15-20(2-4-24(25)29)26(33)31-17-18-7-12-32(13-8-18)22-5-10-30-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17H2,(H,31,33) VYXSHJXKMJITQQ-UHFFFAOYSA-N 13641 3-Oxybenzamide 27::3-[2-(2,4-dichlorophenyl)ethoxy]-4-iodo-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 156 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13641&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23646474 46514033 ZINC14953485 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028408 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)C(C)C InChI=1S/C25H32Cl2N2O3/c1-17(2)29-11-8-18(9-12-29)16-28-25(30)20-5-7-23(31-3)24(14-20)32-13-10-19-4-6-21(26)15-22(19)27/h4-7,14-15,17-18H,8-13,16H2,1-3H3,(H,28,30) KDECAAPOPXMVQG-UHFFFAOYSA-N 13677 3-Oxybenzamide 63::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(propan-2-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 650 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13677&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11465752 46514068 ZINC13643419 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028409 Cc1ccc(CCOc2cc(ccc2F)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C27H30FN3O2/c1-20-2-4-21(5-3-20)12-17-33-26-18-23(6-7-25(26)28)27(32)30-19-22-10-15-31(16-11-22)24-8-13-29-14-9-24/h2-9,13-14,18,22H,10-12,15-17,19H2,1H3,(H,30,32) YDFSVSGREUOAEZ-UHFFFAOYSA-N 13631 3-Oxybenzamide 17::4-fluoro-3-[2-(4-methylphenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 206 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13631&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396292 46514023 ZINC13643365 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028410 COc1ccc(cc1OCCc1ccc(Cl)cn1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C26H29ClN4O3/c1-33-24-5-2-20(16-25(24)34-15-10-22-4-3-21(27)18-29-22)26(32)30-17-19-8-13-31(14-9-19)23-6-11-28-12-7-23/h2-7,11-12,16,18-19H,8-10,13-15,17H2,1H3,(H,30,32) FCFJQOMCLQWCHO-UHFFFAOYSA-N 13666 3-Oxybenzamide 52::3-[2-(5-chloropyridin-2-yl)ethoxy]-4-methoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 54 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13666&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052339 46514058 ZINC13643403 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028411 Clc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C26H27Cl2N3O2/c27-22-4-1-19(2-5-22)11-16-33-25-17-21(3-6-24(25)28)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18H2,(H,30,32) HGCZXLJPRIDMSF-UHFFFAOYSA-N 13668 3-Oxybenzamide 54::4-chloro-3-[2-(4-chlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13668&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052361 46509426 ZINC13643408 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028412 COc1cc(cc(OCCc2ccc(Cl)cc2Cl)c1OC)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C28H31Cl2N3O4/c1-35-25-15-21(16-26(27(25)36-2)37-14-9-20-3-4-22(29)17-24(20)30)28(34)32-18-19-7-12-33(13-8-19)23-5-10-31-11-6-23/h3-6,10-11,15-17,19H,7-9,12-14,18H2,1-2H3,(H,32,34) BUHZALANBOOLCL-UHFFFAOYSA-N 13656 3-Oxybenzamide 42::3-[2-(2,4-dichlorophenyl)ethoxy]-4,5-dimethoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 50 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13656&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052319 46514048 ZINC14953514 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028413 COc1cc(OCCc2ccc(Cl)cc2Cl)cc(c1)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H29Cl2N3O3/c1-34-24-14-21(15-25(17-24)35-13-8-20-2-3-22(28)16-26(20)29)27(33)31-18-19-6-11-32(12-7-19)23-4-9-30-10-5-23/h2-5,9-10,14-17,19H,6-8,11-13,18H2,1H3,(H,31,33) SPNXADOKWAUMPQ-UHFFFAOYSA-N 13655 3-Oxybenzamide 41::3-[2-(2,4-dichlorophenyl)ethoxy]-5-methoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 125 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13655&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396232 46514047 ZINC13643394 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028414 CCOc1cc(cc(OCCc2ccc(Cl)cc2Cl)c1Br)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C28H30BrCl2N3O3/c1-2-36-25-15-21(16-26(27(25)29)37-14-9-20-3-4-22(30)17-24(20)31)28(35)33-18-19-7-12-34(13-8-19)23-5-10-32-11-6-23/h3-6,10-11,15-17,19H,2,7-9,12-14,18H2,1H3,(H,33,35) XOKXLVZTHDYGDO-UHFFFAOYSA-N 13660 3-Oxybenzamide 46::4-bromo-3-[2-(2,4-dichlorophenyl)ethoxy]-5-ethoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 86 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13660&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052336 46514052 ZINC14953531 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028415 Fc1ccc(CCOc2cc(ccc2F)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C26H27F2N3O2/c27-22-4-1-19(2-5-22)11-16-33-25-17-21(3-6-24(25)28)26(32)30-18-20-9-14-31(15-10-20)23-7-12-29-13-8-23/h1-8,12-13,17,20H,9-11,14-16,18H2,(H,30,32) PQLDYDZUMUCCQC-UHFFFAOYSA-N 13630 3-Oxybenzamide 16::4-fluoro-3-[2-(4-fluorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 203 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13630&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396290 46514022 ZINC13643362 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028416 COc1cc(cc(OCCc2ccc(Cl)cc2Cl)c1Br)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H28BrCl2N3O3/c1-35-24-14-20(15-25(26(24)28)36-13-8-19-2-3-21(29)16-23(19)30)27(34)32-17-18-6-11-33(12-7-18)22-4-9-31-10-5-22/h2-5,9-10,14-16,18H,6-8,11-13,17H2,1H3,(H,32,34) GJNNFCMJAHQXBR-UHFFFAOYSA-N 13659 3-Oxybenzamide 45::4-bromo-3-[2-(2,4-dichlorophenyl)ethoxy]-5-methoxy-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13659&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052478 46514051 ZINC03989403 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028417 Clc1ccc(CCOc2cc(ccc2C#N)C(=O)NCC2CCN(CC2)c2ccncc2)c(Cl)c1 InChI=1S/C27H26Cl2N4O2/c28-23-4-3-20(25(29)16-23)9-14-35-26-15-21(1-2-22(26)17-30)27(34)32-18-19-7-12-33(13-8-19)24-5-10-31-11-6-24/h1-6,10-11,15-16,19H,7-9,12-14,18H2,(H,32,34) AZHZJSKJTQJFIZ-UHFFFAOYSA-N 13644 3-Oxybenzamide 30::4-cyano-3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 44 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13644&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052485 46514036 ZINC13643381 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028418 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(Cc2ccnc(O)c2)CC1 InChI=1S/C28H31Cl2N3O4/c1-36-25-5-3-22(15-26(25)37-13-9-21-2-4-23(29)16-24(21)30)28(35)32-17-19-7-11-33(12-8-19)18-20-6-10-31-27(34)14-20/h2-6,10,14-16,19H,7-9,11-13,17-18H2,1H3,(H,31,34)(H,32,35) JEROPZADNPCENF-UHFFFAOYSA-N 50452118 CHEMBL421560 Coagulation factor X Homo sapiens 950 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50452118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50452118&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44327306 225145584 CHEMBL421560 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028419 FC(F)(F)c1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccncc1 InChI=1S/C27H26Cl2F3N3O2/c28-21-3-1-19(24(29)16-21)9-14-37-25-15-20(2-4-23(25)27(30,31)32)26(36)34-17-18-7-12-35(13-8-18)22-5-10-33-11-6-22/h1-6,10-11,15-16,18H,7-9,12-14,17H2,(H,34,36) IVCLCGPMDAQQDD-UHFFFAOYSA-N 13643 3-Oxybenzamide 29::3-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}-4-(trifluoromethyl)benzamide Coagulation factor X Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13643&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052347 46514035 ZINC14953491 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028420 COc1ccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)cc1 InChI=1S/C27H30ClN3O3/c1-33-24-5-2-20(3-6-24)12-17-34-26-18-22(4-7-25(26)28)27(32)30-19-21-10-15-31(16-11-21)23-8-13-29-14-9-23/h2-9,13-14,18,21H,10-12,15-17,19H2,1H3,(H,30,32) UNHPOJGJLQUPNH-UHFFFAOYSA-N 13622 3-Oxybenzamide 8::4-chloro-3-[2-(4-methoxyphenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 314 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13622&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22052493 46514014 ZINC13643346 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028421 COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(CC1)c1ccnc(C)c1 InChI=1S/C28H31Cl2N3O3/c1-19-15-24(7-11-31-19)33-12-8-20(9-13-33)18-32-28(34)22-4-6-26(35-2)27(16-22)36-14-10-21-3-5-23(29)17-25(21)30/h3-7,11,15-17,20H,8-10,12-14,18H2,1-2H3,(H,32,34) ACFHSVNVQHUVJC-UHFFFAOYSA-N 13673 3-Oxybenzamide 59::3-[2-(2,4-dichlorophenyl)ethoxy]-4-methoxy-N-{[1-(2-methylpyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 57 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13673&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11466687 46514064 ZINC13643413 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028422 Clc1ccc(CCOc2cc(cc3OCOc23)C(=O)NCC2CCN(CC2)c2ccncc2)c(Cl)c1 InChI=1S/C27H27Cl2N3O4/c28-21-2-1-19(23(29)15-21)7-12-34-24-13-20(14-25-26(24)36-17-35-25)27(33)31-16-18-5-10-32(11-6-18)22-3-8-30-9-4-22/h1-4,8-9,13-15,18H,5-7,10-12,16-17H2,(H,31,33) IDTTVHUXXPGDJV-UHFFFAOYSA-N 13658 3-Oxybenzamide 44::7-[2-(2,4-dichlorophenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}-2H-1,3-benzodioxole-5-carboxamide Coagulation factor X Homo sapiens 39 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13658&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396298 46514050 ZINC14953525 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50028423 COc1cccc(CCOc2cc(ccc2Cl)C(=O)NCC2CCN(CC2)c2ccncc2)c1 InChI=1S/C27H30ClN3O3/c1-33-24-4-2-3-20(17-24)11-16-34-26-18-22(5-6-25(26)28)27(32)30-19-21-9-14-31(15-10-21)23-7-12-29-13-8-23/h2-8,12-13,17-18,21H,9-11,14-16,19H2,1H3,(H,30,32) KAZPUVKCBZSLAR-UHFFFAOYSA-N 13625 3-Oxybenzamide 11::4-chloro-3-[2-(3-methoxyphenyl)ethoxy]-N-{[1-(pyridin-4-yl)piperidin-4-yl]methyl}benzamide Coagulation factor X Homo sapiens 2494 ChEMBL 10.1016/j.bmcl.2004.03.059 10.7270/Q2XS5WW7 15125936 Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Aventis Pharma Deutschland GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13625&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 23396283 46514017 ZINC13643353 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 560170 Oc1cc(ccc1NC(=O)OCc1ccccc1)N1CCOCC1=O InChI=1S/C18H18N2O5/c21-16-10-14(20-8-9-24-12-17(20)22)6-7-15(16)19-18(23)25-11-13-4-2-1-3-5-13/h1-7,10,21H,8-9,11-12H2,(H,19,23) FFBHFFJDDLITSX-UHFFFAOYSA-N 294039 Process 1::US10106557, Compound 1 Coagulation factor X Homo sapiens 1.01 8.3 US Patent 10.7270/Q2X63Q0W aid1795908 US10106557 Chen, S; Ding, Z; Gong, G; Yan, X; Huang, W; Guo, F; Duan, B; Gao, R; Zhou, P; Lu, X; Dong, G NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294039&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 130280461 381617155 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 560175 Clc1ccc(s1)C(=O)NC[C@@H]1OC(=O)N2[C@H]1COc1cc(ccc21)N1CCCCC1=O InChI=1S/C21H20ClN3O5S/c22-18-7-6-17(31-18)20(27)23-10-16-14-11-29-15-9-12(24-8-2-1-3-19(24)26)4-5-13(15)25(14)21(28)30-16/h4-7,9,14,16H,1-3,8,10-11H2,(H,23,27)/t14-,16-/m0/s1 JCTRHKZXDDIGIB-HOCLYGCPSA-N 50024354 CHEMBL3330444::US10106557, Compound 2 Coagulation factor X Homo sapiens 1.93 8.3 US Patent 10.7270/Q2X63Q0W aid1795908 US10106557 Chen, S; Ding, Z; Gong, G; Yan, X; Huang, W; Guo, F; Duan, B; Gao, R; Zhou, P; Lu, X; Dong, G NORTH CHINA PHARMACEUTICAL NEW DRUG R&D CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50024354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50024354&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 118519579 313064867 CHEMBL3330444 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50052949 CCCCCC(NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)B1O[C@@H]2CC3CC(C3(C)C)[C@]2(C)O1 InChI=1S/C38H52BN3O6/c1-5-6-9-20-33(39-47-32-24-28-23-31(37(28,2)3)38(32,4)48-39)41-34(43)30-19-14-21-42(30)35(44)29(22-26-15-10-7-11-16-26)40-36(45)46-25-27-17-12-8-13-18-27/h7-8,10-13,15-18,28-33H,5-6,9,14,19-25H2,1-4H3,(H,40,45)(H,41,43)/t28?,29-,30-,31?,32+,33?,38-/m0/s1 MUPHEXMZSXMJJT-DTNILZMJSA-N 50034577 CHEMBL291026::Peptide boronate Coagulation factor X Homo sapiens 0.58 ChEMBL 10.1021/jm00009a012 10.7270/Q2QR4W57 7739010 Deadman, JJ; Elgendy, S; Goodwin, CA; Green, D; Baban, JA; Patel, G; Skordalakes, E; Chino, N; Claeson, G; Kakkar, VV Thrombosis Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034577&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44284992 103942743 CHEMBL291026 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50052960 COCCCC(NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(c1ccccc1)c1ccccc1)B1O[C@@H]2CC3CC(C3(C)C)[C@]2(C)O1 InChI=1S/C43H54BN3O7/c1-42(2)32-26-34(42)43(3)35(27-32)53-44(54-43)36(23-15-25-51-4)45-39(48)33-22-14-24-47(33)40(49)38(46-41(50)52-28-29-16-8-5-9-17-29)37(30-18-10-6-11-19-30)31-20-12-7-13-21-31/h5-13,16-21,32-38H,14-15,22-28H2,1-4H3,(H,45,48)(H,46,50)/t32?,33-,34?,35+,36?,38-,43-/m0/s1 FDCBFBSFHLWFFU-CBGVGXTISA-N 50034581 CHEMBL36744::Peptide boronate Coagulation factor X Homo sapiens 7.2 ChEMBL 10.1021/jm00009a012 10.7270/Q2QR4W57 7739010 Deadman, JJ; Elgendy, S; Goodwin, CA; Green, D; Baban, JA; Patel, G; Skordalakes, E; Chino, N; Claeson, G; Kakkar, VV Thrombosis Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034581&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44285253 103942747 CHEMBL36744 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50052962 COCCCC(NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)B1O[C@@H]2CC3CC(C3(C)C)[C@]2(C)O1 InChI=1S/C37H50BN3O7/c1-36(2)27-22-30(36)37(3)31(23-27)47-38(48-37)32(18-12-20-45-4)40-33(42)29-17-11-19-41(29)34(43)28(21-25-13-7-5-8-14-25)39-35(44)46-24-26-15-9-6-10-16-26/h5-10,13-16,27-32H,11-12,17-24H2,1-4H3,(H,39,44)(H,40,42)/t27?,28-,29-,30?,31+,32?,37-/m0/s1 OPOYAWWWOKBVEB-UJDBECHCSA-N 50034574 CHEMBL288150::Peptide boronate Coagulation factor X Homo sapiens 3.1 ChEMBL 10.1021/jm00009a012 10.7270/Q2QR4W57 7739010 Deadman, JJ; Elgendy, S; Goodwin, CA; Green, D; Baban, JA; Patel, G; Skordalakes, E; Chino, N; Claeson, G; Kakkar, VV Thrombosis Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034574&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44285119 103942740 CHEMBL288150 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50052963 Br.CC1(C)C2CC1[C@]1(C)OB(O[C@@H]1C2)C(CCC\C(S)=N\N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 InChI=1S/C37H50BN5O6S.BrH/c1-36(2)26-21-29(36)37(3)30(22-26)48-38(49-37)31(17-10-18-32(50)42-39)41-33(44)28-16-11-19-43(28)34(45)27(20-24-12-6-4-7-13-24)40-35(46)47-23-25-14-8-5-9-15-25;/h4-9,12-15,26-31H,10-11,16-23,39H2,1-3H3,(H,40,46)(H,41,44)(H,42,50);1H/t26?,27-,28-,29?,30+,31?,37-;/m0./s1 UAQQNLPTVQXSEN-OIAZJYILSA-N 50034582 CHEMBL2448441::Peptide boronate Coagulation factor X Homo sapiens 0.848 ChEMBL 10.1021/jm00009a012 10.7270/Q2QR4W57 7739010 Deadman, JJ; Elgendy, S; Goodwin, CA; Green, D; Baban, JA; Patel, G; Skordalakes, E; Chino, N; Claeson, G; Kakkar, VV Thrombosis Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034582&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73355715 103942748 CHEMBL2448441 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50052969 CCCCCC(NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(c1ccccc1)c1ccccc1)B1O[C@@H]2CC3CC(C3(C)C)[C@]2(C)O1 InChI=1S/C44H56BN3O6/c1-5-6-10-25-37(45-53-36-28-33-27-35(43(33,2)3)44(36,4)54-45)46-40(49)34-24-17-26-48(34)41(50)39(47-42(51)52-29-30-18-11-7-12-19-30)38(31-20-13-8-14-21-31)32-22-15-9-16-23-32/h7-9,11-16,18-23,33-39H,5-6,10,17,24-29H2,1-4H3,(H,46,49)(H,47,51)/t33?,34-,35?,36+,37?,39-,44-/m0/s1 QPBFLOWZPFHTHE-ADVKVLRRSA-N 50034583 CHEMBL287918::Peptide boronate Coagulation factor X Homo sapiens 13 ChEMBL 10.1021/jm00009a012 10.7270/Q2QR4W57 7739010 Deadman, JJ; Elgendy, S; Goodwin, CA; Green, D; Baban, JA; Patel, G; Skordalakes, E; Chino, N; Claeson, G; Kakkar, VV Thrombosis Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034583&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44285118 103942749 CHEMBL287918 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50052984 CC1(C)C2CC1[C@]1(C)OB(O[C@@H]1C2)C(Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 InChI=1S/C40H48BN3O6/c1-39(2)30-24-33(39)40(3)34(25-30)49-41(50-40)35(23-28-16-9-5-10-17-28)43-36(45)32-20-13-21-44(32)37(46)31(22-27-14-7-4-8-15-27)42-38(47)48-26-29-18-11-6-12-19-29/h4-12,14-19,30-35H,13,20-26H2,1-3H3,(H,42,47)(H,43,45)/t30?,31-,32-,33?,34+,35?,40-/m0/s1 DLEWBCCCSUQVHV-RFGFGPHLSA-N 50034585 CHEMBL285285::Peptide boronate Coagulation factor X Homo sapiens 1.2 ChEMBL 10.1021/jm00009a012 10.7270/Q2QR4W57 7739010 Deadman, JJ; Elgendy, S; Goodwin, CA; Green, D; Baban, JA; Patel, G; Skordalakes, E; Chino, N; Claeson, G; Kakkar, VV Thrombosis Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034585&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44285281 103942751 CHEMBL285285 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50053019 CCC(C)(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)B1O[C@@H]2CC3CC(C3(C)C)[C@]2(C)O1 InChI=1S/C38H52BN3O6/c1-7-36(2,3)34(39-47-31-23-27-22-30(37(27,4)5)38(31,6)48-39)41-32(43)29-19-14-20-42(29)33(44)28(21-25-15-10-8-11-16-25)40-35(45)46-24-26-17-12-9-13-18-26/h8-13,15-18,27-31,34H,7,14,19-24H2,1-6H3,(H,40,45)(H,41,43)/t27?,28-,29-,30?,31+,34?,38-/m0/s1 GOBXSXIHPUGHDS-MDFDAHAVSA-N 50034579 CHEMBL290577::Peptide boronate Coagulation factor X Homo sapiens 2.6 ChEMBL 10.1021/jm00009a012 10.7270/Q2QR4W57 7739010 Deadman, JJ; Elgendy, S; Goodwin, CA; Green, D; Baban, JA; Patel, G; Skordalakes, E; Chino, N; Claeson, G; Kakkar, VV Thrombosis Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034579&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44285211 103942745 CHEMBL290577 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50053024 CCC(C)(C)C(NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)OCc1ccccc1)B1O[C@@H]2CC3CC(C3(C)C)[C@]2(C)O1 InChI=1S/C42H54BN3O6/c1-7-40(2,3)38(43-51-35-25-31-24-34(41(31,4)5)42(35,6)52-43)45-36(47)33-18-13-21-46(33)37(48)32(44-39(49)50-26-27-14-9-8-10-15-27)23-28-19-20-29-16-11-12-17-30(29)22-28/h8-12,14-17,19-20,22,31-35,38H,7,13,18,21,23-26H2,1-6H3,(H,44,49)(H,45,47)/t31?,32-,33-,34?,35+,38?,42-/m0/s1 XMSAWCPABLSFFM-ATKGNVCISA-N 50034576 CHEMBL288176::Peptide boronate Coagulation factor X Homo sapiens 23 ChEMBL 10.1021/jm00009a012 10.7270/Q2QR4W57 7739010 Deadman, JJ; Elgendy, S; Goodwin, CA; Green, D; Baban, JA; Patel, G; Skordalakes, E; Chino, N; Claeson, G; Kakkar, VV Thrombosis Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034576&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44285352 103942742 CHEMBL288176 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50053050 CC1(C)C2CC1[C@]1(C)OB(O[C@@H]1C2)C(Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OCc1ccccc1)C(c1ccccc1)c1ccccc1 InChI=1S/C46H52BN3O6/c1-45(2)35-28-37(45)46(3)38(29-35)55-47(56-46)39(27-31-17-8-4-9-18-31)48-42(51)36-25-16-26-50(36)43(52)41(49-44(53)54-30-32-19-10-5-11-20-32)40(33-21-12-6-13-22-33)34-23-14-7-15-24-34/h4-15,17-24,35-41H,16,25-30H2,1-3H3,(H,48,51)(H,49,53)/t35?,36-,37?,38+,39?,41-,46-/m0/s1 SAHIWIHDGKJMDR-DWTJSFPDSA-N 50034580 CHEMBL418050::Peptide boronate Coagulation factor X Homo sapiens 4.3 ChEMBL 10.1021/jm00009a012 10.7270/Q2QR4W57 7739010 Deadman, JJ; Elgendy, S; Goodwin, CA; Green, D; Baban, JA; Patel, G; Skordalakes, E; Chino, N; Claeson, G; Kakkar, VV Thrombosis Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034580&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44285312 103942746 CHEMBL418050 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50055477 COC(=O)C(Cc1cccc(c1)C(N)=N)C(CCc1ccccc1)NC(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C33H33N3O3/c1-39-33(38)29(22-24-11-8-14-28(21-24)31(34)35)30(20-15-23-9-4-2-5-10-23)36-32(37)27-18-16-26(17-19-27)25-12-6-3-7-13-25/h2-14,16-19,21,29-30H,15,20,22H2,1H3,(H3,34,35)(H,36,37) JFZUBUPLMKFLQR-UHFFFAOYSA-N 50062682 3-[(Biphenyl-4-carbonyl)-amino]-2-(3-carbamimidoyl-benzyl)-5-phenyl-pentanoic acid methyl ester::CHEMBL141532 Coagulation factor X Homo sapiens 60.0 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062682&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708107 103958204 CHEMBL141532 ZINC27520443 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50061130 CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C=O InChI=1S/C21H32N6O3/c1-24-17(13-15-7-3-2-4-8-15)20(30)27-12-6-10-18(27)19(29)26-16(14-28)9-5-11-25-21(22)23/h2-4,7-8,14,16-18,24H,5-6,9-13H2,1H3,(H,26,29)(H4,22,23,25)/t16-,17+,18-/m0/s1 KAGLWQUWUNBAOO-KSZLIROESA-N 50228863 (S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid ((S)-1-formyl-4-guanidino-butyl)-amide::1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide::5N-[4-amino(imino)methylamino-1-formyl-(1S)-butyl]-1-[2-methylamino-3-phenyl-(2R)-propanoyl]-(5S)-dihydro-1H-5-pyrrolecarboxamide::CHEMBL273196::Me-(D-Phe)-Pro-Arg-CHO Coagulation factor X Homo sapiens 4000 ChEMBL 10.1021/jm00040a001 10.7270/Q2FQ9VPM 8035417 Iwanowicz, EJ; Lau, WF; Lin, J; Roberts, DG; Seiler, SM Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50228863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50228863&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 122267 104097969 CHEMBL273196 ZINC03777328 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50061142 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCNC(N)=N)C(=O)N[C@@H](CC1CCCCC1)[C@@H](O)c1nccs1 InChI=1S/C32H49N7O4S/c1-21(2)18-25(29(42)38-24(19-22-10-5-3-6-11-22)28(41)31-35-16-17-44-31)39-30(43)26(20-23-12-7-4-8-13-23)37-27(40)14-9-15-36-32(33)34/h4,7-8,12-13,16-17,21-22,24-26,28,41H,3,5-6,9-11,14-15,18-20H2,1-2H3,(H,37,40)(H,38,42)(H,39,43)(H4,33,34,36)/t24-,25-,26-,28+/m0/s1 YVAMEIZCNLFMMR-KJNQLLBQSA-N 50039010 (S)-2-[(S)-2-(4-Guanidino-butyrylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid ((1S,2R)-1-cyclohexylmethyl-2-hydroxy-2-thiazol-2-yl-ethyl)-amide::CHEMBL308232 Coagulation factor X Homo sapiens 6000 ChEMBL 10.1021/jm00040a001 10.7270/Q2FQ9VPM 8035417 Iwanowicz, EJ; Lau, WF; Lin, J; Roberts, DG; Seiler, SM Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039010&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9873979 103946273 CHEMBL308232 ZINC26258018 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065603 CCOC(=O)C(Cc1cc2ccc(cc2o1)C(N)=N)c1ccc(O[C@H]2CCNC2)cc1 InChI=1S/C24H27N3O4/c1-2-29-24(28)21(15-5-7-18(8-6-15)30-19-9-10-27-14-19)13-20-11-16-3-4-17(23(25)26)12-22(16)31-20/h3-8,11-12,19,21,27H,2,9-10,13-14H2,1H3,(H3,25,26)/t19-,21?/m0/s1 SOZKWYUMENWVJY-ZQRQZVKFSA-N 50041214 3-(6-Carbamimidoyl-benzofuran-2-yl)-2-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid ethyl ester::CHEMBL19152 Coagulation factor X Homo sapiens 1700 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041214&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10409945 103973019 CHEMBL19152 ZINC13735896 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065607 CC(=N)N1CC[C@@H](C1)Oc1ccc(cc1)C(Cc1ccc2ccc(cc2c1)C(N)=N)C(O)=O InChI=1S/C26H28N4O3/c1-16(27)30-11-10-23(15-30)33-22-8-6-19(7-9-22)24(26(31)32)13-17-2-3-18-4-5-20(25(28)29)14-21(18)12-17/h2-9,12,14,23-24,27H,10-11,13,15H2,1H3,(H3,28,29)(H,31,32)/t23-,24?/m0/s1 AGRCGQSFFMCBRE-UXMRNZNESA-N 50041218 3-(7-Carbamimidoyl-naphthalen-2-yl)-2-{4-[(S)-1-(1-imino-ethyl)-pyrrolidin-3-yloxy]-phenyl}-propionic acid::CHEMBL19660 Coagulation factor X Homo sapiens 160 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041218&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 6914706 103973023 CHEMBL19660 ZINC11686493 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065609 NC(=N)c1ccc2ccc(CC(C(O)=O)c3ccc(O[C@H]4CCNC4)cc3)cc2c1 InChI=1S/C24H25N3O3/c25-23(26)18-4-3-16-2-1-15(11-19(16)13-18)12-22(24(28)29)17-5-7-20(8-6-17)30-21-9-10-27-14-21/h1-8,11,13,21-22,27H,9-10,12,14H2,(H3,25,26)(H,28,29)/t21-,22?/m0/s1 YVXRJLHKWQGQSP-HMTLIYDFSA-N 50041221 3-(7-Carbamimidoyl-naphthalen-2-yl)-2-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid::CHEMBL19139 Coagulation factor X Homo sapiens 200 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041221&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9978512 103973026 CHEMBL19139 ZINC13735932 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065611 CC(=N)N1CC[C@@H](C1)Oc1ccc(cc1)C(Cc1cc2cc(ccc2o1)C(N)=N)C(O)=O InChI=1S/C24H26N4O4/c1-14(25)28-9-8-19(13-28)31-18-5-2-15(3-6-18)21(24(29)30)12-20-11-17-10-16(23(26)27)4-7-22(17)32-20/h2-7,10-11,19,21,25H,8-9,12-13H2,1H3,(H3,26,27)(H,29,30)/t19-,21?/m0/s1 ANKWUHWXZPQHEX-ZQRQZVKFSA-N 50041217 3-(5-Carbamimidoyl-benzofuran-2-yl)-2-{4-[(S)-1-(1-imino-ethyl)-pyrrolidin-3-yloxy]-phenyl}-propionic acid::CHEMBL279077 Coagulation factor X Homo sapiens 500 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041217&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9980363 103973022 CHEMBL279077 ZINC13735938 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065612 CCOC(=O)C(Cc1cc2cc(ccc2o1)C(N)=N)c1ccc(O[C@H]2CCNC2)cc1 InChI=1S/C24H27N3O4/c1-2-29-24(28)21(15-3-6-18(7-4-15)30-19-9-10-27-14-19)13-20-12-17-11-16(23(25)26)5-8-22(17)31-20/h3-8,11-12,19,21,27H,2,9-10,13-14H2,1H3,(H3,25,26)/t19-,21?/m0/s1 BALUOYUEXRRYDQ-ZQRQZVKFSA-N 50041222 3-(5-Carbamimidoyl-benzofuran-2-yl)-2-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid ethyl ester::CHEMBL280162 Coagulation factor X Homo sapiens 1000 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041222&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10454867 103973027 CHEMBL280162 ZINC13735889 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065616 NC(=N)c1ccc2cc(CC(C(O)=O)c3ccc(O[C@H]4CCNC4)cc3)ccc2c1 InChI=1S/C24H25N3O3/c25-23(26)19-4-3-17-11-15(1-2-18(17)13-19)12-22(24(28)29)16-5-7-20(8-6-16)30-21-9-10-27-14-21/h1-8,11,13,21-22,27H,9-10,12,14H2,(H3,25,26)(H,28,29)/t21-,22?/m0/s1 YFNXUXZGVHFDFG-HMTLIYDFSA-N 50041225 3-(6-Carbamimidoyl-naphthalen-2-yl)-2-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid::CHEMBL279959 Coagulation factor X Homo sapiens 4100 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041225&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10318999 103973030 CHEMBL279959 ZINC13735926 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065618 CC(=N)N1CC[C@@H](C1)Oc1ccc(cc1)C(Cc1cc2ccc(cc2o1)C(N)=N)C(O)=O InChI=1S/C24H26N4O4/c1-14(25)28-9-8-19(13-28)31-18-6-4-15(5-7-18)21(24(29)30)12-20-10-16-2-3-17(23(26)27)11-22(16)32-20/h2-7,10-11,19,21,25H,8-9,12-13H2,1H3,(H3,26,27)(H,29,30)/t19-,21?/m0/s1 VWKPFIHYZFRMKQ-ZQRQZVKFSA-N 50041223 3-(6-Carbamimidoyl-benzofuran-2-yl)-2-{4-[(S)-1-(1-imino-ethyl)-pyrrolidin-3-yloxy]-phenyl}-propionic acid::CHEMBL277240 Coagulation factor X Homo sapiens 840.0 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041223&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10094458 103973028 CHEMBL277240 ZINC13735942 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065619 NC(=N)c1ccc2cc(CC(C(O)=O)c3ccc(O[C@H]4CCNC4)cc3)oc2c1 InChI=1S/C22H23N3O4/c23-21(24)15-2-1-14-9-18(29-20(14)10-15)11-19(22(26)27)13-3-5-16(6-4-13)28-17-7-8-25-12-17/h1-6,9-10,17,19,25H,7-8,11-12H2,(H3,23,24)(H,26,27)/t17-,19?/m0/s1 YHAXAOUTROPKEV-KKFHFHRHSA-N 50041227 3-(6-Carbamimidoyl-benzofuran-2-yl)-2-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid::CHEMBL276989 Coagulation factor X Homo sapiens 1700 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041227&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10023491 103973032 CHEMBL276989 ZINC13735920 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065621 NC(=N)c1ccc2oc(cc2c1)C(Cc1ccc(O[C@H]2CCNC2)cc1)C(O)=O InChI=1S/C22H23N3O4/c23-21(24)14-3-6-19-15(10-14)11-20(29-19)18(22(26)27)9-13-1-4-16(5-2-13)28-17-7-8-25-12-17/h1-6,10-11,17-18,25H,7-9,12H2,(H3,23,24)(H,26,27)/t17-,18?/m0/s1 MPFABBYVBCPCKC-ZENAZSQFSA-N 50041229 2-(5-Carbamimidoyl-benzofuran-2-yl)-3-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid::CHEMBL280158 Coagulation factor X Homo sapiens 45000 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041229&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10340538 103973034 CHEMBL280158 ZINC13735954 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065622 CCOC(=O)C(Cc1ccc(O[C@H]2CCNC2)cc1)c1cc2cc(ccc2o1)C(N)=N InChI=1S/C24H27N3O4/c1-2-29-24(28)20(22-13-17-12-16(23(25)26)5-8-21(17)31-22)11-15-3-6-18(7-4-15)30-19-9-10-27-14-19/h3-8,12-13,19-20,27H,2,9-11,14H2,1H3,(H3,25,26)/t19-,20?/m0/s1 SUGLHOFWNHYTPY-XJDOXCRVSA-N 50041230 2-(5-Carbamimidoyl-benzofuran-2-yl)-3-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid ethyl ester::CHEMBL279367 Coagulation factor X Homo sapiens 52000 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041230&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10047815 103973035 CHEMBL279367 ZINC13735949 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065624 NC(=N)c1ccc2oc(CCc3cc4cc(ccc4o3)C(N)=N)cc2c1 InChI=1S/C20H18N4O2/c21-19(22)11-1-5-17-13(7-11)9-15(25-17)3-4-16-10-14-8-12(20(23)24)2-6-18(14)26-16/h1-2,5-10H,3-4H2,(H3,21,22)(H3,23,24) YMOFSDWBUFAIRB-UHFFFAOYSA-N 50041220 1,2-bis(5-amidinobenzofuran-2-yl)ethane::2-(2-{5-[(E)-amino(imino)methyl]-1-benzofuran-2-yl}ethyl)-1-benzofuran-5-carboximidamide::2-(2-{5-[(Z)-amino(imino)methyl]-1-benzofuran-2-yl}ethyl)-1-benzofuran-5-carboximidamide::2-{2-[5-amino(imino)methylbenzo[b]furan-2-yl]ethyl}benzo[b]furan-5-yl-iminomethanamine::CHEMBL279962 Coagulation factor X Homo sapiens 100 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041220&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 47978 103973025 CHEMBL279962 ZINC01844863 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065625 CCOC(=O)C(Cc1ccc2ccc(cc2c1)C(N)=N)c1ccc(O[C@H]2CCNC2)cc1 InChI=1S/C26H29N3O3/c1-2-31-26(30)24(19-7-9-22(10-8-19)32-23-11-12-29-16-23)14-17-3-4-18-5-6-20(25(27)28)15-21(18)13-17/h3-10,13,15,23-24,29H,2,11-12,14,16H2,1H3,(H3,27,28)/t23-,24?/m0/s1 VZKCASWHKFZIEV-UXMRNZNESA-N 50041231 3-(7-Carbamimidoyl-naphthalen-2-yl)-2-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid ethyl ester::CHEMBL277267 Coagulation factor X Homo sapiens 310 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041231&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10365461 103973036 CHEMBL277267 ZINC13735908 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065627 CC(=N)N1CC[C@@H](C1)Oc1ccc(cc1)[C@H](Cc1ccc2ccc(cc2c1)C(N)=N)C(O)=O InChI=1S/C26H28N4O3/c1-16(27)30-11-10-23(15-30)33-22-8-6-19(7-9-22)24(26(31)32)13-17-2-3-18-4-5-20(25(28)29)14-21(18)12-17/h2-9,12,14,23-24,27H,10-11,13,15H2,1H3,(H3,28,29)(H,31,32)/t23-,24-/m0/s1 AGRCGQSFFMCBRE-ZEQRLZLVSA-N 17283 (2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-{[(3S)-1-ethanimidoylpyrrolidin-3-yl]oxy}phenyl)propanoic acid::CHEMBL19902::DX-9065a Coagulation factor X Homo sapiens 70.0 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17283&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search DX9 1MTW,1FAX 122129 46517461 CHEMBL19902 ZINC03791107 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065631 NC(=N)c1ccc2oc(CCc3ccc(O[C@H]4CCNC4)cc3)cc2c1 InChI=1S/C21H23N3O2/c22-21(23)15-4-8-20-16(11-15)12-18(26-20)7-3-14-1-5-17(6-2-14)25-19-9-10-24-13-19/h1-2,4-6,8,11-12,19,24H,3,7,9-10,13H2,(H3,22,23)/t19-/m0/s1 CVFDRPGKRTVOEX-IBGZPJMESA-N 50041215 2-{2-[4-((S)-Pyrrolidin-3-yloxy)-phenyl]-ethyl}-benzofuran-5-carboxamidine::CHEMBL19626 Coagulation factor X Homo sapiens 940.0 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041215&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11725377 103973020 CHEMBL19626 ZINC12354915 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065632 CC(=N)N1CC[C@@H](C1)Oc1ccc(cc1)[C@@H](Cc1ccc2ccc(cc2c1)C(N)=N)C(O)=O InChI=1S/C26H28N4O3/c1-16(27)30-11-10-23(15-30)33-22-8-6-19(7-9-22)24(26(31)32)13-17-2-3-18-4-5-20(25(28)29)14-21(18)12-17/h2-9,12,14,23-24,27H,10-11,13,15H2,1H3,(H3,28,29)(H,31,32)/t23-,24+/m0/s1 AGRCGQSFFMCBRE-BJKOFHAPSA-N 50041224 (R)-3-(7-Carbamimidoyl-naphthalen-2-yl)-2-{4-[(S)-1-(1-imino-ethyl)-pyrrolidin-3-yloxy]-phenyl}-propionic acid::CHEMBL19365 Coagulation factor X Homo sapiens 500 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041224&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 12082573 103973029 CHEMBL19365 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065633 CC(=N)N1CC[C@@H](C1)Oc1ccc(CCc2cc3cc(ccc3o2)C(N)=N)cc1 InChI=1S/C23H26N4O2/c1-15(24)27-11-10-21(14-27)28-19-6-2-16(3-7-19)4-8-20-13-18-12-17(23(25)26)5-9-22(18)29-20/h2-3,5-7,9,12-13,21,24H,4,8,10-11,14H2,1H3,(H3,25,26)/t21-/m0/s1 YOUALJDPRVQZRM-NRFANRHFSA-N 50041216 2-(2-{4-[(S)-1-(1-Imino-ethyl)-pyrrolidin-3-yloxy]-phenyl}-ethyl)-benzofuran-5-carboxamidine::CHEMBL19368::CHEMBL536721 Coagulation factor X Homo sapiens 640 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041216&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10000477 103973021 CHEMBL536721CHEMBL19368 ZINC13735935 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065637 NC(=N)c1ccc2oc(CC(C(O)=O)c3ccc(O[C@H]4CCNC4)cc3)cc2c1 InChI=1S/C22H23N3O4/c23-21(24)14-3-6-20-15(9-14)10-18(29-20)11-19(22(26)27)13-1-4-16(5-2-13)28-17-7-8-25-12-17/h1-6,9-10,17,19,25H,7-8,11-12H2,(H3,23,24)(H,26,27)/t17-,19?/m0/s1 BUZIFYFUSBPIJE-KKFHFHRHSA-N 50041226 3-(5-Carbamimidoyl-benzofuran-2-yl)-2-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid::CHEMBL280157 Coagulation factor X Homo sapiens 1500 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041226&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10091962 103973031 CHEMBL280157 ZINC13735914 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065638 CC(=N)N1CC[C@@H](C1)Oc1ccc(cc1)C(Cc1ccc2cc(ccc2c1)C(N)=N)C(O)=O InChI=1S/C26H28N4O3/c1-16(27)30-11-10-23(15-30)33-22-8-6-18(7-9-22)24(26(31)32)13-17-2-3-20-14-21(25(28)29)5-4-19(20)12-17/h2-9,12,14,23-24,27H,10-11,13,15H2,1H3,(H3,28,29)(H,31,32)/t23-,24?/m0/s1 FDKBUZKECUQYHR-UXMRNZNESA-N 50041219 3-(6-Carbamimidoyl-naphthalen-2-yl)-2-{4-[(S)-1-(1-imino-ethyl)-pyrrolidin-3-yloxy]-phenyl}-propionic acid::CHEMBL19594 Coagulation factor X Homo sapiens 360 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041219&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10366176 103973024 CHEMBL19594 ZINC13558700 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50065640 CCOC(=O)C(Cc1ccc2cc(ccc2c1)C(N)=N)c1ccc(O[C@H]2CCNC2)cc1 InChI=1S/C26H29N3O3/c1-2-31-26(30)24(18-7-9-22(10-8-18)32-23-11-12-29-16-23)14-17-3-4-20-15-21(25(27)28)6-5-19(20)13-17/h3-10,13,15,23-24,29H,2,11-12,14,16H2,1H3,(H3,27,28)/t23-,24?/m0/s1 VWENWTAMDZAVEI-UXMRNZNESA-N 50041228 3-(6-Carbamimidoyl-naphthalen-2-yl)-2-[4-((S)-pyrrolidin-3-yloxy)-phenyl]-propionic acid ethyl ester::CHEMBL279270 Coagulation factor X Homo sapiens 4200 ChEMBL 10.1021/jm00034a018 10.7270/Q2FF3RF6 8164262 Nagahara, T; Yokoyama, Y; Inamura, K; Katakura, S; Komoriya, S; Yamaguchi, H; Hara, T; Iwamoto, M Daiichi Pharmaceutical Company, Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50041228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50041228&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10410499 103973033 CHEMBL279270 ZINC13735902 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50062471 CN[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C=O)c1ccccc1 InChI=1S/C20H30N6O3/c1-23-17(14-7-3-2-4-8-14)19(29)26-12-6-10-16(26)18(28)25-15(13-27)9-5-11-24-20(21)22/h2-4,7-8,13,15-17,23H,5-6,9-12H2,1H3,(H,25,28)(H4,21,22,24)/t15-,16-,17+/m0/s1 HGZDLWBCOWFXST-YESZJQIVSA-N 50060000 (S)-1-((R)-2-Methylamino-2-phenyl-acetyl)-pyrrolidine-2-carboxylic acid ((S)-1-formyl-4-guanidino-butyl)-amide::CHEMBL105205 Coagulation factor X Homo sapiens 2200 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060000&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10386393 103955773 CHEMBL105205 ZINC13765385 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50074981 NC(=N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1Cc2ccccc2CN1)C=O InChI=1S/C21H30N6O3/c22-21(23)24-9-3-7-16(13-28)26-19(29)18-8-4-10-27(18)20(30)17-11-14-5-1-2-6-15(14)12-25-17/h1-2,5-6,13,16-18,25H,3-4,7-12H2,(H,26,29)(H4,22,23,24)/t16-,17+,18-/m0/s1 WXVYOXMMXUJYLQ-KSZLIROESA-N 50046352 1-(1,2,3,4-Tetrahydro-isoquinoline-3-carbonyl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide::CHEMBL2370424 Coagulation factor X Homo sapiens 19.0 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046352&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10070407 103977137 CHEMBL2370424 ZINC36107602 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50074996 C[C@@H](C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1ccccc1 InChI=1S/C20H29N5O3/c1-14(15-7-3-2-4-8-15)19(28)25-12-6-10-17(25)18(27)24-16(13-26)9-5-11-23-20(21)22/h2-4,7-8,13-14,16-17H,5-6,9-12H2,1H3,(H,24,27)(H4,21,22,23)/t14-,16?,17+/m1/s1 JXRKSYPTADMDFW-AQYZNVCMSA-N 50046353 1-(2-Phenyl-butyryl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide::CHEMBL320098 Coagulation factor X Homo sapiens 81000 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046353&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44337925 103977138 CHEMBL320098 ZINC26935847 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075002 CC(C)(C)OC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C=O)c1ccc(F)cc1 InChI=1S/C24H35FN6O5/c1-24(2,3)36-23(35)30-19(15-8-10-16(25)11-9-15)21(34)31-13-5-7-18(31)20(33)29-17(14-32)6-4-12-28-22(26)27/h8-11,14,17-19H,4-7,12-13H2,1-3H3,(H,29,33)(H,30,35)(H4,26,27,28)/t17-,18-,19-/m0/s1 UNTYULOIKNKYHN-FHWLQOOXSA-N 50046364 CHEMBL2370416::{1-(4-Fluoro-phenyl)-2-[2-(1-formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester Coagulation factor X Homo sapiens 91000 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046364&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10029213 103977149 CHEMBL2370416 ZINC26937426 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075006 CC(C)(C)OC(=O)N[C@@H](CN1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1ccccc1 InChI=1S/C24H38N6O4/c1-24(2,3)34-23(33)29-19(17-9-5-4-6-10-17)15-30-14-8-12-20(30)21(32)28-18(16-31)11-7-13-27-22(25)26/h4-6,9-10,16,18-20H,7-8,11-15H2,1-3H3,(H,28,32)(H,29,33)(H4,25,26,27)/t18?,19-,20-/m0/s1 GSAUCCBWUDXOGL-YPJRHXLCSA-N 50046369 CHEMBL320407::{2-[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester Coagulation factor X Homo sapiens 190000 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046369&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44337899 103977154 CHEMBL320407 ZINC26851632 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075007 C[C@H](C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1ccccc1 InChI=1S/C20H29N5O3/c1-14(15-7-3-2-4-8-15)19(28)25-12-6-10-17(25)18(27)24-16(13-26)9-5-11-23-20(21)22/h2-4,7-8,13-14,16-17H,5-6,9-12H2,1H3,(H,24,27)(H4,21,22,23)/t14-,16?,17-/m0/s1 JXRKSYPTADMDFW-NZEUDUFCSA-N 50046365 1-(2-Phenyl-butyryl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide::CHEMBL323963 Coagulation factor X Homo sapiens 31000 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046365&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44338032 103977150 CHEMBL323963 ZINC26937113 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075008 CC[C@H](C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1ccccc1 InChI=1S/C21H31N5O3/c1-2-17(15-8-4-3-5-9-15)20(29)26-13-7-11-18(26)19(28)25-16(14-27)10-6-12-24-21(22)23/h3-5,8-9,14,16-18H,2,6-7,10-13H2,1H3,(H,25,28)(H4,22,23,24)/t16?,17-,18-/m0/s1 VLBYXUBKMAZVDQ-FQECFTEESA-N 50046363 1-(2-Phenyl-pentanoyl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide::CHEMBL327113 Coagulation factor X Homo sapiens 33000 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046363&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44338012 103977148 CHEMBL327113 ZINC26938738 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075013 CC(C)(C)OC(=O)N[C@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C=O InChI=1S/C24H42N6O5/c1-24(2,3)35-23(34)29-19(16-9-5-4-6-10-16)21(33)30-14-8-12-18(30)20(32)28-17(15-31)11-7-13-27-22(25)26/h15-19H,4-14H2,1-3H3,(H,28,32)(H,29,34)(H4,25,26,27)/t17-,18-,19+/m0/s1 PBMZSYYXSHEKKY-GBESFXJTSA-N 50046362 CHEMBL319930::{1-Cyclohexyl-2-[2-(1-formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester Coagulation factor X Homo sapiens 81.0 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046362&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10051441 103977147 CHEMBL319930 ZINC26936141 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075019 NC(=N)NCCCC(NC(=O)[C@@H]1CCCN1C(=O)c1cc2ccccc2[nH]1)C=O InChI=1S/C20H26N6O3/c21-20(22)23-9-3-6-14(12-27)24-18(28)17-8-4-10-26(17)19(29)16-11-13-5-1-2-7-15(13)25-16/h1-2,5,7,11-12,14,17,25H,3-4,6,8-10H2,(H,24,28)(H4,21,22,23)/t14?,17-/m0/s1 VSFNKZHGNMFXQU-JRZJBTRGSA-N 50046354 1-(1H-Indole-2-carbonyl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide::CHEMBL108848 Coagulation factor X Homo sapiens 20000 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046354&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44337935 103977139 CHEMBL108848 ZINC26939205 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075023 CC(C)(C)OC(=O)NC(C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1cccc(c1)C(F)(F)F InChI=1S/C25H35F3N6O5/c1-24(2,3)39-23(38)33-19(15-7-4-8-16(13-15)25(26,27)28)21(37)34-12-6-10-18(34)20(36)32-17(14-35)9-5-11-31-22(29)30/h4,7-8,13-14,17-19H,5-6,9-12H2,1-3H3,(H,32,36)(H,33,38)(H4,29,30,31)/t17?,18-,19?/m0/s1 KRCPVLWZQMKRME-XBMUEBEBSA-N 50046368 CHEMBL320988::[2-[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-1-(3-trifluoromethyl-phenyl)-ethyl]-carbamic acid tert-butyl ester Coagulation factor X Homo sapiens 1400 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046368&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44337917 103977153 CHEMBL320988 ZINC26937725 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075040 CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C=O InChI=1S/C25H38N6O5/c1-25(2,3)36-24(35)30-19(15-17-9-5-4-6-10-17)22(34)31-14-8-12-20(31)21(33)29-18(16-32)11-7-13-28-23(26)27/h4-6,9-10,16,18-20H,7-8,11-15H2,1-3H3,(H,29,33)(H,30,35)(H4,26,27,28)/t18-,19+,20-/m0/s1 JDXUSWQJCGTBLN-ZCNNSNEGSA-N 50046360 CHEMBL104472::{1-Benzyl-2-[2-(1-formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester Coagulation factor X Homo sapiens 45.0 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046360&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 6917805 103977145 CHEMBL104472 ZINC26937432 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075044 CC(C)(C)OC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1cccc2ccccc12 InChI=1S/C28H38N6O5/c1-28(2,3)39-27(38)33-23(21-13-6-10-18-9-4-5-12-20(18)21)25(37)34-16-8-14-22(34)24(36)32-19(17-35)11-7-15-31-26(29)30/h4-6,9-10,12-13,17,19,22-23H,7-8,11,14-16H2,1-3H3,(H,32,36)(H,33,38)(H4,29,30,31)/t19?,22-,23-/m0/s1 PLAJAOHXCUUQEL-MXQSGTKOSA-N 50046359 CHEMBL109109::{2-[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-1-naphthalen-1-yl-2-oxo-ethyl}-carbamic acid tert-butyl ester Coagulation factor X Homo sapiens 210 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046359&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44337894 103977144 CHEMBL109109 ZINC26939860 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075046 NC(=N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)C1CCc2ccccc2N1)C=O InChI=1S/C21H30N6O3/c22-21(23)24-11-3-6-15(13-28)25-19(29)18-8-4-12-27(18)20(30)17-10-9-14-5-1-2-7-16(14)26-17/h1-2,5,7,13,15,17-18,26H,3-4,6,8-12H2,(H,25,29)(H4,22,23,24)/t15-,17?,18-/m0/s1 LFIGHRNZFXNOEV-YKOWGRMDSA-N 50046357 1-(1,2,3,4-Tetrahydro-quinoline-2-carbonyl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide::CHEMBL2370422 Coagulation factor X Homo sapiens 660000 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046357&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10409551 103977142 CHEMBL2370422 ZINC13861288 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075051 CO[C@H](C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1ccccc1 InChI=1S/C20H29N5O4/c1-29-17(14-7-3-2-4-8-14)19(28)25-12-6-10-16(25)18(27)24-15(13-26)9-5-11-23-20(21)22/h2-4,7-8,13,15-17H,5-6,9-12H2,1H3,(H,24,27)(H4,21,22,23)/t15?,16-,17-/m0/s1 MNRGKDPLVYDHCV-BSOSBYQFSA-N 50046371 1-(2-Methoxy-2-phenyl-acetyl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide::CHEMBL107598 Coagulation factor X Homo sapiens 27000 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046371&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44337989 103977156 CHEMBL107598 ZINC26953764 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075053 N[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C=O)c1ccccc1 InChI=1S/C19H28N6O3/c20-16(13-6-2-1-3-7-13)18(28)25-11-5-9-15(25)17(27)24-14(12-26)8-4-10-23-19(21)22/h1-3,6-7,12,14-16H,4-5,8-11,20H2,(H,24,27)(H4,21,22,23)/t14-,15-,16+/m0/s1 GOZOOJYBIIQGLI-HRCADAONSA-N 50046356 1-(2-Amino-2-phenyl-acetyl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide::CHEMBL104305 Coagulation factor X Homo sapiens 19.0 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046356&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10091675 103977141 CHEMBL104305 ZINC26955464 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075059 CC(C)(C)OC(=O)NC(C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1ccc(Cl)c(Cl)c1 InChI=1S/C24H34Cl2N6O5/c1-24(2,3)37-23(36)31-19(14-8-9-16(25)17(26)12-14)21(35)32-11-5-7-18(32)20(34)30-15(13-33)6-4-10-29-22(27)28/h8-9,12-13,15,18-19H,4-7,10-11H2,1-3H3,(H,30,34)(H,31,36)(H4,27,28,29)/t15?,18-,19?/m0/s1 JLNWZEIIEIIPES-OBONGRFPSA-N 50046373 CHEMBL108670::{1-(3,4-Dichloro-phenyl)-2-[2-(1-formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester Coagulation factor X Homo sapiens 69.0 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046373&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44337986 103977158 CHEMBL108670 ZINC26936502 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075060 CC(C)(C)OC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C=O)c1ccc(O)cc1 InChI=1S/C24H36N6O6/c1-24(2,3)36-23(35)29-19(15-8-10-17(32)11-9-15)21(34)30-13-5-7-18(30)20(33)28-16(14-31)6-4-12-27-22(25)26/h8-11,14,16,18-19,32H,4-7,12-13H2,1-3H3,(H,28,33)(H,29,35)(H4,25,26,27)/t16-,18-,19+/m0/s1 QVDOSWZUBZJJCH-YTQUADARSA-N 50046367 CHEMBL321322::[2-[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-1-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester Coagulation factor X Homo sapiens 16000 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046367&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10006319 103977152 CHEMBL321322 ZINC26851156 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075066 CC(C)(C)OC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C=O)c1ccccc1 InChI=1S/C24H36N6O5/c1-24(2,3)35-23(34)29-19(16-9-5-4-6-10-16)21(33)30-14-8-12-18(30)20(32)28-17(15-31)11-7-13-27-22(25)26/h4-6,9-10,15,17-19H,7-8,11-14H2,1-3H3,(H,28,32)(H,29,34)(H4,25,26,27)/t17-,18-,19+/m0/s1 VDEXCODLWRXIIG-GBESFXJTSA-N 50046372 CHEMBL318998::{2-[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-1-phenyl-ethyl}-carbamic acid tert-butyl ester Coagulation factor X Homo sapiens 98.0 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046372&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10074230 103977157 CHEMBL318998 ZINC26851605 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075072 CC(C)(C)OC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C=O)c1ccc(F)cc1 InChI=1S/C24H35FN6O5/c1-24(2,3)36-23(35)30-19(15-8-10-16(25)11-9-15)21(34)31-13-5-7-18(31)20(33)29-17(14-32)6-4-12-28-22(26)27/h8-11,14,17-19H,4-7,12-13H2,1-3H3,(H,29,33)(H,30,35)(H4,26,27,28)/t17-,18-,19+/m0/s1 UNTYULOIKNKYHN-GBESFXJTSA-N 50046374 CHEMBL102216::{1-(4-Fluoro-phenyl)-2-[2-(1-formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester Coagulation factor X Homo sapiens 1600 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046374&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10074922 103977159 CHEMBL102216 ZINC26935488 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075075 CC(C)(C)OC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1cccc2ccccc12 InChI=1S/C28H38N6O5/c1-28(2,3)39-27(38)33-23(21-13-6-10-18-9-4-5-12-20(18)21)25(37)34-16-8-14-22(34)24(36)32-19(17-35)11-7-15-31-26(29)30/h4-6,9-10,12-13,17,19,22-23H,7-8,11,14-16H2,1-3H3,(H,32,36)(H,33,38)(H4,29,30,31)/t19?,22-,23+/m0/s1 PLAJAOHXCUUQEL-NWZLQDFTSA-N 50046355 CHEMBL110898::{2-[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-1-naphthalen-1-yl-2-oxo-ethyl}-carbamic acid tert-butyl ester Coagulation factor X Homo sapiens 1400 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046355&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44337945 103977140 CHEMBL110898 ZINC26938318 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075080 NC(=N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NCCc2ccccc12)C=O InChI=1S/C21H30N6O3/c22-21(23)25-10-3-6-15(13-28)26-19(29)17-8-4-12-27(17)20(30)18-16-7-2-1-5-14(16)9-11-24-18/h1-2,5,7,13,15,17-18,24H,3-4,6,8-12H2,(H,26,29)(H4,22,23,25)/t15-,17-,18+/m0/s1 GBNKGLWEDJOYBL-RYQLBKOJSA-N 50046370 1-(1,2,3,4-Tetrahydro-isoquinoline-1-carbonyl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide::CHEMBL2370421 Coagulation factor X Homo sapiens 640 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046370&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9801905 103977155 CHEMBL2370421 ZINC12355087 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075082 CC(C)(C)OC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C=O)c1ccsc1 InChI=1S/C22H34N6O5S/c1-22(2,3)33-21(32)27-17(14-8-11-34-13-14)19(31)28-10-5-7-16(28)18(30)26-15(12-29)6-4-9-25-20(23)24/h8,11-13,15-17H,4-7,9-10H2,1-3H3,(H,26,30)(H,27,32)(H4,23,24,25)/t15-,16-,17+/m0/s1 VGFDMPDZPNMFII-YESZJQIVSA-N 50046361 CHEMBL2370418::{2-[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-2-oxo-1-thiophen-3-yl-ethyl}-carbamic acid tert-butyl ester Coagulation factor X Homo sapiens 190 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046361&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10368488 103977146 CHEMBL2370418 ZINC26937999 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50075083 CC(C)(C)OC(=O)N[C@@H](C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C=O)c1ccc2ccccc2c1 InChI=1S/C28H38N6O5/c1-28(2,3)39-27(38)33-23(20-13-12-18-8-4-5-9-19(18)16-20)25(37)34-15-7-11-22(34)24(36)32-21(17-35)10-6-14-31-26(29)30/h4-5,8-9,12-13,16-17,21-23H,6-7,10-11,14-15H2,1-3H3,(H,32,36)(H,33,38)(H4,29,30,31)/t21?,22-,23+/m0/s1 YSHIHBNJUPKMRT-ATTQYFOMSA-N 50046358 CHEMBL110780::{2-[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-1-naphthalen-2-yl-2-oxo-ethyl}-carbamic acid tert-butyl ester Coagulation factor X Homo sapiens 50 ChEMBL 10.1021/jm00055a002 10.7270/Q2930S8J 8426361 Shuman, RT; Rothenberger, RB; Campbell, CS; Smith, GF; Gifford-Moore, DS; Gesellchen, PD Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046358&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44337884 103977143 CHEMBL110780 ZINC26939551 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090523 CCCC(CCC)C(=O)N[C@@H](CC(=O)OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C=O InChI=1S/C24H42N6O6/c1-4-8-16(9-5-2)21(33)29-18(14-20(32)36-3)23(35)30-13-7-11-19(30)22(34)28-17(15-31)10-6-12-27-24(25)26/h15-19H,4-14H2,1-3H3,(H,28,34)(H,29,33)(H4,25,26,27)/t17-,18-,19-/m0/s1 ICMSWQUELAGTTR-FHWLQOOXSA-N 50054482 (S)-4-[(S)-2-((S)-1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin-1-yl]-4-oxo-3-(2-propyl-pentanoylamino)-butyric acid methyl ester::CHEMBL141676 Coagulation factor X Homo sapiens 301 ChEMBL 10.1021/jm960607j 10.7270/Q2CR5SFV 8917638 Levy, OE; Semple, JE; Lim, ML; Reiner, J; Rote, WE; Dempsey, E; Richard, BM; Zhang, E; Tulinsky, A; Ripka, WC; Nutt, RF Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054482&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9806376 103951090 CHEMBL141676 ZINC13760079 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090524 CCCC(CCC)C(=O)N[C@@H](CC(=O)OC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1CCCN(C1)C(N)=N)C=O InChI=1S/C27H46N6O6/c1-4-8-19(9-5-2)24(36)31-21(15-23(35)39-3)26(38)33-13-7-11-22(33)25(37)30-20(17-34)14-18-10-6-12-32(16-18)27(28)29/h17-22H,4-16H2,1-3H3,(H3,28,29)(H,30,37)(H,31,36)/t18?,20-,21-,22-/m0/s1 HLEXEFPWIXSUIV-WDHNVLQZSA-N 50054483 (S)-4-{(S)-2-[(S)-1-(1-Carbamimidoyl-piperidin-3-ylmethyl)-2-oxo-ethylcarbamoyl]-pyrrolidin-1-yl}-4-oxo-3-(2-propyl-pentanoylamino)-butyric acid methyl ester::CHEMBL342838 Coagulation factor X Homo sapiens >2500 ChEMBL 10.1021/jm960607j 10.7270/Q2CR5SFV 8917638 Levy, OE; Semple, JE; Lim, ML; Reiner, J; Rote, WE; Dempsey, E; Richard, BM; Zhang, E; Tulinsky, A; Ripka, WC; Nutt, RF Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054483&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10325271 103951091 CHEMBL342838 ZINC14294262 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090525 NC(=N)NCCC[C@H](NC(=O)CN1CCCC[C@H](NS(=O)(=O)Cc2ccccc2)C1=O)C=O InChI=1S/C21H32N6O5S/c22-21(23)24-11-6-9-17(14-28)25-19(29)13-27-12-5-4-10-18(20(27)30)26-33(31,32)15-16-7-2-1-3-8-16/h1-3,7-8,14,17-18,26H,4-6,9-13,15H2,(H,25,29)(H4,22,23,24)/t17-,18-/m0/s1 PTYYNQHOHSWREY-ROUUACIJSA-N 50054484 CHEMBL344204::CVS-1778::N-((S)-1-Formyl-4-guanidino-butyl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide Coagulation factor X Homo sapiens 20.6 ChEMBL 10.1021/jm960607j 10.7270/Q2CR5SFV 8917638 Levy, OE; Semple, JE; Lim, ML; Reiner, J; Rote, WE; Dempsey, E; Richard, BM; Zhang, E; Tulinsky, A; Ripka, WC; Nutt, RF Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054484&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9891337 103951092 CHEMBL344204 ZINC13439339 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090527 NC(=N)N1CCC[C@H](C[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C=O)C1 InChI=1S/C23H34N6O5S/c24-23(25)29-11-4-8-18(13-29)12-19(15-30)26-21(31)14-28-10-5-9-20(22(28)32)27-35(33,34)16-17-6-2-1-3-7-17/h1-3,6-7,15,18-20,27H,4-5,8-14,16H2,(H3,24,25)(H,26,31)/t18-,19+,20+/m1/s1 DATYERRDSFNBDN-AABGKKOBSA-N 50054485 CHEMBL342604::N-[(S)-1-((R)-1-Carbamimidoyl-piperidin-3-ylmethyl)-2-oxo-ethyl]-2-((S)-2-oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-acetamide Coagulation factor X Homo sapiens >25000 ChEMBL 10.1021/jm960607j 10.7270/Q2CR5SFV 8917638 Levy, OE; Semple, JE; Lim, ML; Reiner, J; Rote, WE; Dempsey, E; Richard, BM; Zhang, E; Tulinsky, A; Ripka, WC; Nutt, RF Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054485&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 0IV 1BB0,1ZZZ 10006399 103951093 CHEMBL342604 ZINC13760081 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090531 NC(=N)N1CCCC(C[C@H](NC(=O)CN2CCCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C=O)C1 InChI=1S/C24H36N6O5S/c25-24(26)30-12-6-9-19(14-30)13-20(16-31)27-22(32)15-29-11-5-4-10-21(23(29)33)28-36(34,35)17-18-7-2-1-3-8-18/h1-3,7-8,16,19-21,28H,4-6,9-15,17H2,(H3,25,26)(H,27,32)/t19?,20-,21-/m0/s1 JTGAZLYCGWWGII-AKQSQHNNSA-N 50054487 CHEMBL342914::N-[(S)-1-(1-Carbamimidoyl-piperidin-3-ylmethyl)-2-oxo-ethyl]-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide Coagulation factor X Homo sapiens >2500 ChEMBL 10.1021/jm960607j 10.7270/Q2CR5SFV 8917638 Levy, OE; Semple, JE; Lim, ML; Reiner, J; Rote, WE; Dempsey, E; Richard, BM; Zhang, E; Tulinsky, A; Ripka, WC; Nutt, RF Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054487&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 15431805 103951095 CHEMBL342914 ZINC13760082 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090535 NC(=N)N1CCC[C@@H](C[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C=O)C1 InChI=1S/C23H34N6O5S/c24-23(25)29-11-4-8-18(13-29)12-19(15-30)26-21(31)14-28-10-5-9-20(22(28)32)27-35(33,34)16-17-6-2-1-3-7-17/h1-3,6-7,15,18-20,27H,4-5,8-14,16H2,(H3,24,25)(H,26,31)/t18-,19-,20-/m0/s1 DATYERRDSFNBDN-UFYCRDLUSA-N 50054486 CHEMBL141424::N-[(S)-1-((S)-1-Carbamimidoyl-piperidin-3-ylmethyl)-2-oxo-ethyl]-2-((S)-2-oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-acetamide Coagulation factor X Homo sapiens >25000 ChEMBL 10.1021/jm960607j 10.7270/Q2CR5SFV 8917638 Levy, OE; Semple, JE; Lim, ML; Reiner, J; Rote, WE; Dempsey, E; Richard, BM; Zhang, E; Tulinsky, A; Ripka, WC; Nutt, RF Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054486&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 0KV 1YYY,1CA8 10074927 103951094 CHEMBL141424 ZINC03943047 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090540 NC(=N)NCCC[C@H](NC(=O)CN1CCC[C@H](NS(=O)(=O)Cc2ccccc2)C1=O)C=O InChI=1S/C20H30N6O5S/c21-20(22)23-10-4-8-16(13-27)24-18(28)12-26-11-5-9-17(19(26)29)25-32(30,31)14-15-6-2-1-3-7-15/h1-3,6-7,13,16-17,25H,4-5,8-12,14H2,(H,24,28)(H4,21,22,23)/t16-,17-/m0/s1 WZYFZDIYCCGIQM-IRXDYDNUSA-N 50054488 CHEMBL138441::CVS-1178::N-((S)-1-Formyl-4-guanidino-butyl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-acetamide Coagulation factor X Homo sapiens >2500 ChEMBL 10.1021/jm960607j 10.7270/Q2CR5SFV 8917638 Levy, OE; Semple, JE; Lim, ML; Reiner, J; Rote, WE; Dempsey, E; Richard, BM; Zhang, E; Tulinsky, A; Ripka, WC; Nutt, RF Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054488&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9847373 103951096 CHEMBL138441 ZINC13760080 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090542 NC(=N)N1CCCC(C[C@H](NC(=O)CN2CCCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C=O)C1 InChI=1S/C24H36N6O5S/c25-24(26)30-12-6-9-19(14-30)13-20(16-31)27-22(32)15-29-11-5-4-10-21(23(29)33)28-36(34,35)17-18-7-2-1-3-8-18/h1-3,7-8,16,19-21,28H,4-6,9-15,17H2,(H3,25,26)(H,27,32)/t19?,20-,21-/m0/s1 JTGAZLYCGWWGII-AKQSQHNNSA-N 50054487 CHEMBL342914::N-[(S)-1-(1-Carbamimidoyl-piperidin-3-ylmethyl)-2-oxo-ethyl]-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide Coagulation factor X Homo sapiens >2500 ChEMBL 10.1021/jm960607j 10.7270/Q2CR5SFV 8917638 Levy, OE; Semple, JE; Lim, ML; Reiner, J; Rote, WE; Dempsey, E; Richard, BM; Zhang, E; Tulinsky, A; Ripka, WC; Nutt, RF Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054487&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 15431805 103951095 CHEMBL342914 ZINC13760082 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090555 COC(=O)c1ccccc1CS(=O)(=O)N[C@H]1CCCCN(CC(=O)N[C@H]2CCCC(C2O)C(N)=N)C1=O InChI=1S/C24H35N5O7S/c1-36-24(33)16-8-3-2-7-15(16)14-37(34,35)28-19-10-4-5-12-29(23(19)32)13-20(30)27-18-11-6-9-17(21(18)31)22(25)26/h2-3,7-8,17-19,21,28,31H,4-6,9-14H2,1H3,(H3,25,26)(H,27,30)/t17?,18-,19-,21?/m0/s1 OGPZZSRTWGPAJE-JMDAGXMHSA-N 50054494 2-({(S)-1-[((S)-3-Carbamimidoyl-2-hydroxy-cyclohexylcarbamoyl)-methyl]-2-oxo-azepan-3-ylsulfamoyl}-methyl)-benzoic acid methyl ester::CHEMBL337365 Coagulation factor X Homo sapiens 471 ChEMBL 10.1021/jm960572n 10.7270/Q28051QT 8917639 Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Hakanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054494&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359810 103951102 CHEMBL337365 ZINC27520778 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090556 NC(=N)C1CCC[C@H](NC(=O)CN2CCC[C@@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O InChI=1S/C21H31N5O5S/c22-20(23)15-8-4-9-16(19(15)28)24-18(27)12-26-11-5-10-17(21(26)29)25-32(30,31)13-14-6-2-1-3-7-14/h1-3,6-7,15-17,19,25,28H,4-5,8-13H2,(H3,22,23)(H,24,27)/t15?,16-,17+,19?/m0/s1 KXKMUXRHSOBPJF-DHADLLTHSA-N 50054489 CHEMBL139656::N-((S)-3-Carbamimidoyl-2-hydroxy-cyclohexyl)-2-((R)-2-oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-acetamide Coagulation factor X Homo sapiens 2500 ChEMBL 10.1021/jm960572n 10.7270/Q28051QT 8917639 Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Hakanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054489&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359755 103951097 CHEMBL139656 ZINC36107657 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090557 NC(=N)C1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)NC3CCCCC3)C2=O)C1O InChI=1S/C20H36N6O5S/c21-19(22)14-8-4-9-15(18(14)28)23-17(27)12-26-11-5-10-16(20(26)29)25-32(30,31)24-13-6-2-1-3-7-13/h13-16,18,24-25,28H,1-12H2,(H3,21,22)(H,23,27)/t14?,15-,16-,18?/m0/s1 IMDBNXVGVFXYFG-LPMVOBIJSA-N 50054495 CHEMBL422470::Lactum Sulfonamide analogue Coagulation factor X Homo sapiens 1950 ChEMBL 10.1021/jm960572n 10.7270/Q28051QT 8917639 Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Hakanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054495&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359805 103951103 CHEMBL422470 ZINC36107648 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090561 CC(N1CCC[C@H](NS(=O)(=O)Cc2ccccc2)C1=O)C(=O)N[C@H]1CCCC(C1O)C(N)=N InChI=1S/C22H33N5O5S/c1-14(21(29)25-17-10-5-9-16(19(17)28)20(23)24)27-12-6-11-18(22(27)30)26-33(31,32)13-15-7-3-2-4-8-15/h2-4,7-8,14,16-19,26,28H,5-6,9-13H2,1H3,(H3,23,24)(H,25,29)/t14?,16?,17-,18-,19?/m0/s1 BIOWNVOXFGFXII-KUVDFHCCSA-N 50054499 CHEMBL334454::N-((S)-3-Carbamimidoyl-2-hydroxy-cyclohexyl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-propionamide Coagulation factor X Homo sapiens 2500 ChEMBL 10.1021/jm960572n 10.7270/Q28051QT 8917639 Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Hakanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054499&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359794 103951107 CHEMBL334454 ZINC36107645 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090565 NC(=N)C1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O InChI=1S/C21H31N5O5S/c22-20(23)15-8-4-9-16(19(15)28)24-18(27)12-26-11-5-10-17(21(26)29)25-32(30,31)13-14-6-2-1-3-7-14/h1-3,6-7,15-17,19,25,28H,4-5,8-13H2,(H3,22,23)(H,24,27)/t15?,16-,17-,19?/m0/s1 KXKMUXRHSOBPJF-VIHIWDAPSA-N 50054502 CHEMBL140494::N-((S)-3-Carbamimidoyl-2-hydroxy-cyclohexyl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-acetamide Coagulation factor X Homo sapiens 2500 ChEMBL 10.1021/jm960572n 10.7270/Q28051QT 8917639 Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Hakanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054502&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359723 103951110 CHEMBL140494 ZINC36107641 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090566 CCCCS(=O)(=O)N[C@H]1CCCN(CC(=O)N[C@H]2CCCC(C2O)C(N)=N)C1=O InChI=1S/C18H33N5O5S/c1-2-3-10-29(27,28)22-14-8-5-9-23(18(14)26)11-15(24)21-13-7-4-6-12(16(13)25)17(19)20/h12-14,16,22,25H,2-11H2,1H3,(H3,19,20)(H,21,24)/t12?,13-,14-,16?/m0/s1 HCCOVNMWPQQJTR-WJEHIRDRSA-N 50054501 2-[(S)-3-(Butane-1-sulfonylamino)-2-oxo-piperidin-1-yl]-N-((S)-3-carbamimidoyl-2-hydroxy-cyclohexyl)-acetamide::CHEMBL140545 Coagulation factor X Homo sapiens 2500 ChEMBL 10.1021/jm960572n 10.7270/Q28051QT 8917639 Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Hakanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054501&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359724 103951109 CHEMBL140545 ZINC27520118 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090568 CC(C)(C)OC(=O)N[C@H]1CCCN(CC(=O)N[C@H]2CCCC(C2O)C(N)=N)C1=O InChI=1S/C19H33N5O5/c1-19(2,3)29-18(28)23-13-8-5-9-24(17(13)27)10-14(25)22-12-7-4-6-11(15(12)26)16(20)21/h11-13,15,26H,4-10H2,1-3H3,(H3,20,21)(H,22,25)(H,23,28)/t11?,12-,13-,15?/m0/s1 JQIGGADUNOGQQW-FMPXUHTOSA-N 50054500 CHEMBL140646::{(S)-1-[((S)-3-Carbamimidoyl-2-hydroxy-cyclohexylcarbamoyl)-methyl]-2-oxo-piperidin-3-yl}-carbamic acid tert-butyl ester Coagulation factor X Homo sapiens 2500 ChEMBL 10.1021/jm960572n 10.7270/Q28051QT 8917639 Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Hakanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054500&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359703 103951108 CHEMBL140646 ZINC27520889 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090573 NC(=N)C1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)c3cccc4ccccc34)C2=O)[C@@H]1O InChI=1S/C24H31N5O5S/c25-23(26)17-9-4-10-18(22(17)31)27-21(30)14-29-13-5-11-19(24(29)32)28-35(33,34)20-12-3-7-15-6-1-2-8-16(15)20/h1-3,6-8,12,17-19,22,28,31H,4-5,9-11,13-14H2,(H3,25,26)(H,27,30)/t17?,18-,19-,22+/m0/s1 SWQSIILIBYINLN-PSJRLOAUSA-N 50054503 CHEMBL263924::N-((1S,2R)-3-Carbamimidoyl-2-hydroxy-cyclohexyl)-2-[(S)-3-(naphthalene-1-sulfonylamino)-2-oxo-piperidin-1-yl]-acetamide Coagulation factor X Homo sapiens 2500 ChEMBL 10.1021/jm960572n 10.7270/Q28051QT 8917639 Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Hakanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054503&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359754 103951111 CHEMBL263924 ZINC27522478 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090581 NC(=N)C1CCC[C@H](NC(=O)CN2CCCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O InChI=1S/C22H33N5O5S/c23-21(24)16-9-6-11-17(20(16)29)25-19(28)13-27-12-5-4-10-18(22(27)30)26-33(31,32)14-15-7-2-1-3-8-15/h1-3,7-8,16-18,20,26,29H,4-6,9-14H2,(H3,23,24)(H,25,28)/t16?,17-,18-,20?/m0/s1 JXHRRVFVLWWLCI-NRGCRIOASA-N 50054493 CHEMBL343805::N-((S)-3-Carbamimidoyl-2-hydroxy-cyclohexyl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide Coagulation factor X Homo sapiens 20.6 ChEMBL 10.1021/jm960572n 10.7270/Q28051QT 8917639 Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Hakanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054493&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359730 103951101 CHEMBL343805 ZINC34689174 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090584 NC(=N)C1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)c3ccccc3)C2=O)C1O InChI=1S/C20H29N5O5S/c21-19(22)14-8-4-9-15(18(14)27)23-17(26)12-25-11-5-10-16(20(25)28)24-31(29,30)13-6-2-1-3-7-13/h1-3,6-7,14-16,18,24,27H,4-5,8-12H2,(H3,21,22)(H,23,26)/t14?,15-,16-,18?/m0/s1 ICZUVAJGIFVYIM-LPMVOBIJSA-N 50054491 2-((S)-3-Benzenesulfonylamino-2-oxo-piperidin-1-yl)-N-((S)-3-carbamimidoyl-2-hydroxy-cyclohexyl)-acetamide::CHEMBL141106 Coagulation factor X Homo sapiens 1100 ChEMBL 10.1021/jm960572n 10.7270/Q28051QT 8917639 Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Hakanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054491&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44360123 103951099 CHEMBL141106 ZINC34689178 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090586 CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)N[C@H]1CCCC(C1O)C(N)=N InChI=1S/C22H33N5O3/c1-25-17(13-14-7-3-2-4-8-14)22(30)27-12-6-11-18(27)21(29)26-16-10-5-9-15(19(16)28)20(23)24/h2-4,7-8,15-19,25,28H,5-6,9-13H2,1H3,(H3,23,24)(H,26,29)/t15?,16-,17+,18+,19?/m0/s1 GIJSEQPSPRTDPP-OLOUCDKRSA-N 50054498 (R)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid ((S)-3-carbamimidoyl-2-hydroxy-cyclohexyl)-amide::CHEMBL423543 Coagulation factor X Homo sapiens >2500 ChEMBL 10.1021/jm960572n 10.7270/Q28051QT 8917639 Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Hakanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054498&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359885 103951106 CHEMBL423543 ZINC27518995 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090587 CCCC(CCC)C(=O)N[C@@H](CC(=O)OC)C(=O)N1CCC[C@@H]1C(=O)N[C@H]1CCCC(C1O)C(N)=N InChI=1S/C25H43N5O6/c1-4-8-15(9-5-2)23(33)29-18(14-20(31)36-3)25(35)30-13-7-12-19(30)24(34)28-17-11-6-10-16(21(17)32)22(26)27/h15-19,21,32H,4-14H2,1-3H3,(H3,26,27)(H,28,34)(H,29,33)/t16?,17-,18-,19+,21?/m0/s1 FBHFAKDPYSBTTM-XPKGASNUSA-N 50054492 (S)-4-[(R)-2-((S)-3-Carbamimidoyl-2-hydroxy-cyclohexylcarbamoyl)-pyrrolidin-1-yl]-4-oxo-3-(2-propyl-pentanoylamino)-butyric acid methyl ester::CHEMBL141574 Coagulation factor X Homo sapiens 290 ChEMBL 10.1021/jm960572n 10.7270/Q28051QT 8917639 Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Hakanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054492&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359735 103951100 CHEMBL141574 ZINC27519548 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090592 NC(=N)C1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)CCc3ccccc3)C2=O)C1O InChI=1S/C22H33N5O5S/c23-21(24)16-8-4-9-17(20(16)29)25-19(28)14-27-12-5-10-18(22(27)30)26-33(31,32)13-11-15-6-2-1-3-7-15/h1-3,6-7,16-18,20,26,29H,4-5,8-14H2,(H3,23,24)(H,25,28)/t16?,17-,18-,20?/m0/s1 KSPYJLUHOLRXAV-NRGCRIOASA-N 50054490 CHEMBL138243::N-((S)-3-Carbamimidoyl-2-hydroxy-cyclohexyl)-2-[(S)-2-oxo-3-(2-phenyl-ethanesulfonylamino)-piperidin-1-yl]-acetamide Coagulation factor X Homo sapiens 2500 ChEMBL 10.1021/jm960572n 10.7270/Q28051QT 8917639 Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Hakanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054490&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359726 103951098 CHEMBL138243 ZINC34689166 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090594 NC(=N)C1CCC[C@H](NC(=O)CN2CCCC[C@H](NS(=O)(=O)c3ccccc3)C2=O)C1O InChI=1S/C21H31N5O5S/c22-20(23)15-9-6-11-16(19(15)28)24-18(27)13-26-12-5-4-10-17(21(26)29)25-32(30,31)14-7-2-1-3-8-14/h1-3,7-8,15-17,19,25,28H,4-6,9-13H2,(H3,22,23)(H,24,27)/t15?,16-,17-,19?/m0/s1 CZYFQAJCCZGMEU-VIHIWDAPSA-N 50054504 2-((S)-3-Benzenesulfonylamino-2-oxo-azepan-1-yl)-N-((S)-3-carbamimidoyl-2-hydroxy-cyclohexyl)-acetamide::CHEMBL140890 Coagulation factor X Homo sapiens 479 ChEMBL 10.1021/jm960572n 10.7270/Q28051QT 8917639 Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Hakanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054504&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359906 103951112 CHEMBL140890 ZINC36107637 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50090598 NC(=N)C1CCCC(NC(=O)CN2CC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O InChI=1S/C20H29N5O5S/c21-19(22)14-7-4-8-15(18(14)27)23-17(26)11-25-10-9-16(20(25)28)24-31(29,30)12-13-5-2-1-3-6-13/h1-3,5-6,14-16,18,24,27H,4,7-12H2,(H3,21,22)(H,23,26)/t14?,15?,16-,18?/m0/s1 BESVJPPKTOOXIB-HVEGKCCWSA-N 50054505 CHEMBL421760::N-(3-Carbamimidoyl-2-hydroxy-cyclohexyl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-pyrrolidin-1-yl)-acetamide Coagulation factor X Homo sapiens 2500 ChEMBL 10.1021/jm960572n 10.7270/Q28051QT 8917639 Semple, JE; Rowley, DC; Brunck, TK; Ha-Uong, T; Minami, NK; Owens, TD; Tamura, SY; Goldman, EA; Siev, DV; Ardecky, RJ; Carpenter, SH; Ge, Y; Richard, BM; Nolan, TG; Hakanson, K; Tulinsky, A; Nutt, RF; Ripka, WC Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054505&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359756 103951113 CHEMBL421760 ZINC34689176 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50096700 N[C@H](C(C1CCCCC1)C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)NCC1CCC(N)CC1 InChI=1S/C27H48N4O2/c28-22-15-13-19(14-16-22)18-30-26(32)23-12-7-17-31(23)27(33)25(29)24(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h19-25H,1-18,28-29H2,(H,30,32)/t19?,22?,23-,25+/m0/s1 SYJMIXHRYXUAGD-FEROLFGZSA-N 50057826 (S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide::1-(2-Amino-3,3-dicyclohexyl-propionyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide::CHEMBL289395 Coagulation factor X Homo sapiens 95000 ChEMBL 10.1021/jm970140s 10.7270/Q2PR7V29 9171866 Tucker, TJ; Lumma, WC; Lewis, SD; Gardell, SJ; Lucas, BJ; Baskin, EP; Woltmann, R; Lynch, JJ; Lyle, EA; Appleby, SD; Chen, IW; Dancheck, KB; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50057826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50057826&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10367012 103953805 CHEMBL289395 ZINC13761994 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50101498 FC(F)CN1C[C@@H]([C@H](C1)C(=O)Nc1ccc(cc1F)-n1ccccc1=O)C(=O)Nc1ccc(Cl)cn1 InChI=1S/C24H21ClF3N5O3/c25-14-4-7-21(29-10-14)31-24(36)17-12-32(13-20(27)28)11-16(17)23(35)30-19-6-5-15(9-18(19)26)33-8-2-1-3-22(33)34/h1-10,16-17,20H,11-13H2,(H,30,35)(H,29,31,36)/t16-,17-/m0/s1 DVMCMTVFXINJGW-IRXDYDNUSA-N 50324743 (3R,4R)-1-(2,2-DIFLUORO-ETHYL)-PYRROLIDINE-3,4-DICARBOXYLIC ACID 3-[(5-CHLORO-PYRIDIN-2-YL)-AMIDE]-4-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYL]-AMIDE}::(3R,4R)-N3-(5-chloropyridin-2-yl)-1-(2,2-difluoroethyl)-N4-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)pyrrolidine-3,4-dicarboxamide::CHEMBL1221913 Coagulation factor X Homo sapiens 3.7 ChEMBL 10.1016/j.bmcl.2010.06.126 10.7270/Q2542NSG 20650636 Anselm, L; Banner, DW; Benz, J; Zbinden, KG; Himber, J; Hilpert, H; Huber, W; Kuhn, B; Mary, JL; Otteneder, MB; Panday, N; Ricklin, F; Stahl, M; Thomi, S; Haap, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324743&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search XBV 2XBV 24849206 117646064 CHEMBL1221913 ZINC14210921 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50101532 COC(=O)N1C[C@@H]([C@H](C1)C(=O)Nc1ccc(cc1F)-n1ccccc1=O)C(=O)Nc1ccc(Cl)cn1 InChI=1S/C24H21ClFN5O5/c1-36-24(35)30-12-16(17(13-30)23(34)29-20-8-5-14(25)11-27-20)22(33)28-19-7-6-15(10-18(19)26)31-9-3-2-4-21(31)32/h2-11,16-17H,12-13H2,1H3,(H,28,33)(H,27,29,34)/t16-,17-/m0/s1 PDKKUZJALFQAFX-IRXDYDNUSA-N 50324745 (3R,4R)-methyl 3-(5-chloropyridin-2-ylcarbamoyl)-4-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenylcarbamoyl)pyrrolidine-1-carboxylate::CHEMBL1221916 Coagulation factor X Homo sapiens 27 ChEMBL 10.1016/j.bmcl.2010.06.126 10.7270/Q2542NSG 20650636 Anselm, L; Banner, DW; Benz, J; Zbinden, KG; Himber, J; Hilpert, H; Huber, W; Kuhn, B; Mary, JL; Otteneder, MB; Panday, N; Ricklin, F; Stahl, M; Thomi, S; Haap, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324745&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 49864483 117646066 CHEMBL1221916 ZINC58576009 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50101537 COC(=O)N1C[C@@H]([C@H](C1)C(=O)Nc1ccc(cc1F)-n1ccccc1=O)C(=O)Nc1ccc(Cl)cn1 InChI=1S/C24H21ClFN5O5/c1-36-24(35)30-12-16(17(13-30)23(34)29-20-8-5-14(25)11-27-20)22(33)28-19-7-6-15(10-18(19)26)31-9-3-2-4-21(31)32/h2-11,16-17H,12-13H2,1H3,(H,28,33)(H,27,29,34)/t16-,17-/m0/s1 PDKKUZJALFQAFX-IRXDYDNUSA-N 50324745 (3R,4R)-methyl 3-(5-chloropyridin-2-ylcarbamoyl)-4-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenylcarbamoyl)pyrrolidine-1-carboxylate::CHEMBL1221916 Coagulation factor X Homo sapiens 27 ChEMBL 10.1016/j.bmcl.2010.06.126 10.7270/Q2542NSG 20650636 Anselm, L; Banner, DW; Benz, J; Zbinden, KG; Himber, J; Hilpert, H; Huber, W; Kuhn, B; Mary, JL; Otteneder, MB; Panday, N; Ricklin, F; Stahl, M; Thomi, S; Haap, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324745&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 49864483 117646066 CHEMBL1221916 ZINC58576009 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102600 Nc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(Cl)c(Cl)c2)NS(=O)(=O)Cc2ccccc2)cn1 InChI=1S/C27H29Cl2N5O4S/c28-21-10-8-19(13-22(21)29)14-23(33-39(37,38)17-18-5-2-1-3-6-18)27(36)34-12-4-7-24(34)26(35)32-16-20-9-11-25(30)31-15-20/h1-3,5-6,8-11,13,15,23-24,33H,4,7,12,14,16-17H2,(H2,30,31)(H,32,35)/t23-,24+/m1/s1 MNLYTTAJTRVGFR-RPWUZVMVSA-N 50060739 (S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethanesulfonylamino-propionyl]-pyrrolidine-2-carboxylic acid (6-amino-pyridin-3-ylmethyl)-amide::CHEMBL121982 Coagulation factor X Homo sapiens 7600 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060739&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10817210 103956375 CHEMBL121982 ZINC27200293 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102605 Nc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(Cl)c(Cl)c2)NS(=O)(=O)Cc2ccccc2)cc1 InChI=1S/C28H30Cl2N4O4S/c29-23-13-10-21(15-24(23)30)16-25(33-39(37,38)18-20-5-2-1-3-6-20)28(36)34-14-4-7-26(34)27(35)32-17-19-8-11-22(31)12-9-19/h1-3,5-6,8-13,15,25-26,33H,4,7,14,16-18,31H2,(H,32,35)/t25-,26+/m1/s1 WOQBLVJNTIATHT-FTJBHMTQSA-N 50060745 (S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethanesulfonylamino-propionyl]-pyrrolidine-2-carboxylic acid 4-amino-benzylamide::CHEMBL122801 Coagulation factor X Homo sapiens 10000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060745&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10841125 103956381 CHEMBL122801 ZINC27202396 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102606 Cc1cc(N)nc(C)c1CNC(=O)[C@@H]1CCCN1C(=O)[C@H](NC(=O)OC(C)(C)C)C(C1CCCCC1)C1CCCCC1 InChI=1S/C33H53N5O4/c1-21-19-27(34)36-22(2)25(21)20-35-30(39)26-17-12-18-38(26)31(40)29(37-32(41)42-33(3,4)5)28(23-13-8-6-9-14-23)24-15-10-7-11-16-24/h19,23-24,26,28-29H,6-18,20H2,1-5H3,(H2,34,36)(H,35,39)(H,37,41)/t26-,29+/m0/s1 CVJJKAXDDGZLEP-LITSAYRRSA-N 50060746 ((R)-2-{(S)-2-[(6-Amino-2,4-dimethyl-pyridin-3-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-dicyclohexylmethyl-2-oxo-ethyl)-carbamic acid tert-butyl ester::CHEMBL123142 Coagulation factor X Homo sapiens 16000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060746&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11801417 103956382 CHEMBL123142 ZINC27197088 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102607 Cc1cc(N)nc(C)c1CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccc(Cl)c(Cl)c1)NS(=O)(=O)Cc1ccccc1 InChI=1S/C29H33Cl2N5O4S/c1-18-13-27(32)34-19(2)22(18)16-33-28(37)26-9-6-12-36(26)29(38)25(15-21-10-11-23(30)24(31)14-21)35-41(39,40)17-20-7-4-3-5-8-20/h3-5,7-8,10-11,13-14,25-26,35H,6,9,12,15-17H2,1-2H3,(H2,32,34)(H,33,37)/t25-,26+/m1/s1 UWOLGNVHETVCHA-FTJBHMTQSA-N 50060747 (S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethanesulfonylamino-propionyl]-pyrrolidine-2-carboxylic acid (6-amino-2,4-dimethyl-pyridin-3-ylmethyl)-amide::CHEMBL338788 Coagulation factor X Homo sapiens 52000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060747&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10841532 103956383 CHEMBL338788 ZINC27207218 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102608 Cc1cc(N)nc(C)c1CNC(=O)[C@@H]1CCCN1C(=O)[C@H](N)C(c1ccccc1)c1ccccc1 InChI=1S/C28H33N5O2/c1-18-16-24(29)32-19(2)22(18)17-31-27(34)23-14-9-15-33(23)28(35)26(30)25(20-10-5-3-6-11-20)21-12-7-4-8-13-21/h3-8,10-13,16,23,25-26H,9,14-15,17,30H2,1-2H3,(H2,29,32)(H,31,34)/t23-,26+/m0/s1 QBNJJQBEAIGWTA-JYFHCDHNSA-N 50060748 (S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid (6-amino-2,4-dimethyl-pyridin-3-ylmethyl)-amide::CHEMBL122601 Coagulation factor X Homo sapiens 240000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060748&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10600484 103956384 CHEMBL122601 ZINC13766347 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102609 CC(C)(C)OC(=O)N[C@H](C(C1CCCCC1)C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(N)nc1 InChI=1S/C31H49N5O4/c1-31(2,3)40-30(39)35-27(26(22-11-6-4-7-12-22)23-13-8-5-9-14-23)29(38)36-18-10-15-24(36)28(37)34-20-21-16-17-25(32)33-19-21/h16-17,19,22-24,26-27H,4-15,18,20H2,1-3H3,(H2,32,33)(H,34,37)(H,35,39)/t24-,27+/m0/s1 IFZNRMMNIPIRFG-RPLLCQBOSA-N 50060741 ((R)-2-{(S)-2-[(6-Amino-pyridin-3-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-dicyclohexylmethyl-2-oxo-ethyl)-carbamic acid tert-butyl ester::CHEMBL122331 Coagulation factor X Homo sapiens 4400 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060741&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10370457 103956377 CHEMBL122331 ZINC27199218 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102610 N[C@H](C(c1ccccc1)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1csc(N)n1 InChI=1S/C24H27N5O2S/c25-21(20(16-8-3-1-4-9-16)17-10-5-2-6-11-17)23(31)29-13-7-12-19(29)22(30)27-14-18-15-32-24(26)28-18/h1-6,8-11,15,19-21H,7,12-14,25H2,(H2,26,28)(H,27,30)/t19-,21+/m0/s1 LNYPUAWZFHLMGZ-PZJWPPBQSA-N 50060749 (S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid (2-amino-thiazol-4-ylmethyl)-amide::CHEMBL122432 Coagulation factor X Homo sapiens >100000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060749&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10623402 103956385 CHEMBL122432 ZINC13766352 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102612 N[C@H](C(c1ccccc1)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(N)nc1 InChI=1S/C26H29N5O2/c27-22-14-13-18(16-29-22)17-30-25(32)21-12-7-15-31(21)26(33)24(28)23(19-8-3-1-4-9-19)20-10-5-2-6-11-20/h1-6,8-11,13-14,16,21,23-24H,7,12,15,17,28H2,(H2,27,29)(H,30,32)/t21-,24+/m0/s1 OBSSMRFDAAAZQM-XUZZJYLKSA-N 50060751 (S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid (6-amino-pyridin-3-ylmethyl)-amide::CHEMBL96486 Coagulation factor X Homo sapiens 94000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060751&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11797515 103956387 CHEMBL96486 ZINC13766344 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102613 Nc1cc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(Cl)c(Cl)c2)NS(=O)(=O)Cc2ccccc2)cs1 InChI=1S/C26H28Cl2N4O4S2/c27-20-9-8-18(11-21(20)28)12-22(31-38(35,36)16-17-5-2-1-3-6-17)26(34)32-10-4-7-23(32)25(33)30-14-19-13-24(29)37-15-19/h1-3,5-6,8-9,11,13,15,22-23,31H,4,7,10,12,14,16,29H2,(H,30,33)/t22-,23+/m1/s1 GUMYXHIUQUSDIR-PKTZIBPZSA-N 50060744 (S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethanesulfonylamino-propionyl]-pyrrolidine-2-carboxylic acid (5-amino-thiophen-3-ylmethyl)-amide::CHEMBL331179 Coagulation factor X Homo sapiens >100000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060744&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10651120 103956380 CHEMBL331179 ZINC49734238 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102615 N[C@H](C(C1CCCCC1)C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)NCc1csc(N)n1 InChI=1S/C24H39N5O2S/c25-21(20(16-8-3-1-4-9-16)17-10-5-2-6-11-17)23(31)29-13-7-12-19(29)22(30)27-14-18-15-32-24(26)28-18/h15-17,19-21H,1-14,25H2,(H2,26,28)(H,27,30)/t19-,21+/m0/s1 ISYOJGORNOWSJJ-PZJWPPBQSA-N 50060740 (S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyrrolidine-2-carboxylic acid (2-amino-thiazol-4-ylmethyl)-amide::CHEMBL331181 Coagulation factor X Homo sapiens >100000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060740&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10671702 103956376 CHEMBL331181 ZINC13766349 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102619 Clc1ccc(C[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)NCc2ccccc2)cc1Cl InChI=1S/C28H29Cl2N3O4S/c29-23-14-13-22(16-24(23)30)17-25(32-38(36,37)19-21-10-5-2-6-11-21)28(35)33-15-7-12-26(33)27(34)31-18-20-8-3-1-4-9-20/h1-6,8-11,13-14,16,25-26,32H,7,12,15,17-19H2,(H,31,34)/t25-,26+/m1/s1 DPAUUXUZXKZLOZ-FTJBHMTQSA-N 50060754 (S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethanesulfonylamino-propionyl]-pyrrolidine-2-carboxylic acid benzylamide::CHEMBL123759 Coagulation factor X Homo sapiens 14000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060754&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10793236 103956390 CHEMBL123759 ZINC27197009 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102620 Cc1cc(N)nc(C)c1CNC(=O)[C@@H]1CCCN1C(=O)[C@H](NC(=O)OC(C)(C)C)C(c1ccccc1)c1ccccc1 InChI=1S/C33H41N5O4/c1-21-19-27(34)36-22(2)25(21)20-35-30(39)26-17-12-18-38(26)31(40)29(37-32(41)42-33(3,4)5)28(23-13-8-6-9-14-23)24-15-10-7-11-16-24/h6-11,13-16,19,26,28-29H,12,17-18,20H2,1-5H3,(H2,34,36)(H,35,39)(H,37,41)/t26-,29+/m0/s1 WKDSOFLIZLFPJH-LITSAYRRSA-N 50060755 ((R)-2-{(S)-2-[(6-Amino-2,4-dimethyl-pyridin-3-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-benzhydryl-2-oxo-ethyl)-carbamic acid tert-butyl ester::CHEMBL337923 Coagulation factor X Homo sapiens 160000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060755&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10626893 103956391 CHEMBL337923 ZINC03831733 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102621 Clc1ccc(C[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)NCc2cccnc2)cc1Cl InChI=1S/C27H28Cl2N4O4S/c28-22-11-10-20(14-23(22)29)15-24(32-38(36,37)18-19-6-2-1-3-7-19)27(35)33-13-5-9-25(33)26(34)31-17-21-8-4-12-30-16-21/h1-4,6-8,10-12,14,16,24-25,32H,5,9,13,15,17-18H2,(H,31,34)/t24-,25+/m1/s1 ZGSQQUUFGWQGEL-RPBOFIJWSA-N 50060757 (S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethanesulfonylamino-propionyl]-pyrrolidine-2-carboxylic acid (pyridin-3-ylmethyl)-amide::CHEMBL124408 Coagulation factor X Homo sapiens 230000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060757&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10698376 103956393 CHEMBL124408 ZINC27196550 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102624 CC(C)(C)OC(=O)N[C@H](C(c1ccccc1)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1csc(N)n1 InChI=1S/C29H35N5O4S/c1-29(2,3)38-28(37)33-24(23(19-11-6-4-7-12-19)20-13-8-5-9-14-20)26(36)34-16-10-15-22(34)25(35)31-17-21-18-39-27(30)32-21/h4-9,11-14,18,22-24H,10,15-17H2,1-3H3,(H2,30,32)(H,31,35)(H,33,37)/t22-,24+/m0/s1 ZYDZQUONGVZJLJ-LADGPHEKSA-N 50060753 ((R)-2-{(S)-2-[(2-Amino-thiazol-4-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-benzhydryl-2-oxo-ethyl)-carbamic acid tert-butyl ester::CHEMBL121661 Coagulation factor X Homo sapiens >100000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060753&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10745242 103956389 CHEMBL121661 ZINC27193099 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102627 CC(C)(C)OC(=O)N[C@H](C(C1CCCCC1)C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)NCc1csc(N)c1 InChI=1S/C30H48N4O4S/c1-30(2,3)38-29(37)33-26(25(21-11-6-4-7-12-21)22-13-8-5-9-14-22)28(36)34-16-10-15-23(34)27(35)32-18-20-17-24(31)39-19-20/h17,19,21-23,25-26H,4-16,18,31H2,1-3H3,(H,32,35)(H,33,37)/t23-,26+/m0/s1 FLMHEBGFVPRVIF-JYFHCDHNSA-N 50060756 ((R)-2-{(S)-2-[(5-Amino-thiophen-3-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-dicyclohexylmethyl-2-oxo-ethyl)-carbamic acid tert-butyl ester::CHEMBL421272 Coagulation factor X Homo sapiens 27000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060756&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10626697 103956392 CHEMBL421272 ZINC27199225 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102630 CC(C)(C)OC(=O)N[C@H](C(c1ccccc1)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(N)nc1 InChI=1S/C31H37N5O4/c1-31(2,3)40-30(39)35-27(26(22-11-6-4-7-12-22)23-13-8-5-9-14-23)29(38)36-18-10-15-24(36)28(37)34-20-21-16-17-25(32)33-19-21/h4-9,11-14,16-17,19,24,26-27H,10,15,18,20H2,1-3H3,(H2,32,33)(H,34,37)(H,35,39)/t24-,27+/m0/s1 FSPMPGPDTBXDDA-RPLLCQBOSA-N 50060759 ((R)-2-{(S)-2-[(6-Amino-pyridin-3-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-benzhydryl-2-oxo-ethyl)-carbamic acid tert-butyl ester::CHEMBL122488 Coagulation factor X Homo sapiens >200000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060759&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10792619 103956395 CHEMBL122488 ZINC27206427 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102638 CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(N)cc1 InChI=1S/C26H34N4O4/c1-26(2,3)34-25(33)29-21(16-18-8-5-4-6-9-18)24(32)30-15-7-10-22(30)23(31)28-17-19-11-13-20(27)14-12-19/h4-6,8-9,11-14,21-22H,7,10,15-17,27H2,1-3H3,(H,28,31)(H,29,33)/t21-,22+/m1/s1 CBRWXZBHBLDJCP-YADHBBJMSA-N 50060758 CHEMBL331160::{(R)-2-[(S)-2-(4-Amino-benzylcarbamoyl)-pyrrolidin-1-yl]-1-benzyl-2-oxo-ethyl}-carbamic acid tert-butyl ester Coagulation factor X Homo sapiens 420000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060758&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11798429 103956394 CHEMBL331160 ZINC13766341 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102639 Cc1cc(N)nc(C)c1CNC(=O)[C@@H]1CCCN1C(=O)[C@H](N)C(C1CCCCC1)C1CCCCC1 InChI=1S/C28H45N5O2/c1-18-16-24(29)32-19(2)22(18)17-31-27(34)23-14-9-15-33(23)28(35)26(30)25(20-10-5-3-6-11-20)21-12-7-4-8-13-21/h16,20-21,23,25-26H,3-15,17,30H2,1-2H3,(H2,29,32)(H,31,34)/t23-,26+/m0/s1 ZPHJYZGQZKAQSF-JYFHCDHNSA-N 50060752 (S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyrrolidine-2-carboxylic acid (6-amino-2,4-dimethyl-pyridin-3-ylmethyl)-amide::CHEMBL123942 Coagulation factor X Homo sapiens 160000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060752&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10791003 103956388 CHEMBL123942 ZINC03831708 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102643 N[C@H](C(C1CCCCC1)C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)NCc1ccc(N)nc1 InChI=1S/C26H41N5O2/c27-22-14-13-18(16-29-22)17-30-25(32)21-12-7-15-31(21)26(33)24(28)23(19-8-3-1-4-9-19)20-10-5-2-6-11-20/h13-14,16,19-21,23-24H,1-12,15,17,28H2,(H2,27,29)(H,30,32)/t21-,24+/m0/s1 DUTMSPYSKLRLIM-XUZZJYLKSA-N 50060760 (S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyrrolidine-2-carboxylic acid (6-amino-pyridin-3-ylmethyl)-amide::CHEMBL421437 Coagulation factor X Homo sapiens 8300 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060760&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9868633 103956396 CHEMBL421437 ZINC27194544 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102648 CC(C)(C)OC(=O)N[C@H](C(C1CCCCC1)C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)NCc1csc(N)n1 InChI=1S/C29H47N5O4S/c1-29(2,3)38-28(37)33-24(23(19-11-6-4-7-12-19)20-13-8-5-9-14-20)26(36)34-16-10-15-22(34)25(35)31-17-21-18-39-27(30)32-21/h18-20,22-24H,4-17H2,1-3H3,(H2,30,32)(H,31,35)(H,33,37)/t22-,24+/m0/s1 GBZBLLVKJIQDQX-LADGPHEKSA-N 50060742 ((R)-2-{(S)-2-[(2-Amino-thiazol-4-ylmethyl)-carbamoyl]-pyrrolidin-1-yl}-1-dicyclohexylmethyl-2-oxo-ethyl)-carbamic acid tert-butyl ester::CHEMBL420334 Coagulation factor X Homo sapiens >100000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060742&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10626722 103956378 CHEMBL420334 ZINC27196146 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102651 CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NC[C@H]1CCC(N)CC1 InChI=1S/C22H34N4O2/c1-24-19(14-16-6-3-2-4-7-16)22(28)26-13-5-8-20(26)21(27)25-15-17-9-11-18(23)12-10-17/h2-4,6-7,17-20,24H,5,8-15,23H2,1H3,(H,25,27)/t17-,18?,19-,20+/m1/s1 MDSVGJAUFNXYRR-XUBOLADHSA-N 50056771 (2S)-N-[(4-aminocyclohexyl)methyl]-1-[(2R)-2-(methylamino)-3-phenylpropanoyl]pyrrolidine-2-carboxamide Coagulation factor X Homo sapiens >1000000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50056771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50056771&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search MIN 1TOM 448763 103952921 ZINC03831736 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102657 Clc1ccc(C[C@@H](NS(=O)(=O)Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)NCc2ccncc2)cc1Cl InChI=1S/C27H28Cl2N4O4S/c28-22-9-8-21(15-23(22)29)16-24(32-38(36,37)18-20-5-2-1-3-6-20)27(35)33-14-4-7-25(33)26(34)31-17-19-10-12-30-13-11-19/h1-3,5-6,8-13,15,24-25,32H,4,7,14,16-18H2,(H,31,34)/t24-,25+/m1/s1 ZNNGNRAVHSUUKA-RPBOFIJWSA-N 50060750 (S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethanesulfonylamino-propionyl]-pyrrolidine-2-carboxylic acid (pyridin-4-ylmethyl)-amide::CHEMBL331908 Coagulation factor X Homo sapiens >200000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060750&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10650805 103956386 CHEMBL331908 ZINC27200250 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50102664 Nc1nc(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccc(Cl)c(Cl)c2)NS(=O)(=O)Cc2ccccc2)cs1 InChI=1S/C25H27Cl2N5O4S2/c26-19-9-8-17(11-20(19)27)12-21(31-38(35,36)15-16-5-2-1-3-6-16)24(34)32-10-4-7-22(32)23(33)29-13-18-14-37-25(28)30-18/h1-3,5-6,8-9,11,14,21-22,31H,4,7,10,12-13,15H2,(H2,28,30)(H,29,33)/t21-,22+/m1/s1 PZYHGMLSFGSYMS-YADHBBJMSA-N 50060761 (S)-1-[(R)-3-(3,4-Dichloro-phenyl)-2-phenylmethanesulfonylamino-propionyl]-pyrrolidine-2-carboxylic acid (2-amino-thiazol-4-ylmethyl)-amide::CHEMBL435012 Coagulation factor X Homo sapiens >100000 ChEMBL 10.1021/jm970493r 10.7270/Q289150N 9371237 Feng, DM; Gardell, SJ; Lewis, SD; Bock, MG; Chen, Z; Freidinger, RM; Naylor-Olsen, AM; Ramjit, HG; Woltmann, R; Baskin, EP; Lynch, JJ; Lucas, R; Shafer, JA; Dancheck, KB; Chen, IW; Mao, SS; Krueger, JA; Hare, TR; Mulichak, AM; Vacca, JP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060761&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10698758 103956397 CHEMBL435012 ZINC27207224 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107132 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(cc1)C1CCCCC1)\C=C\c1ccccc1 InChI=1S/C33H37N3O3/c1-39-33(38)29(22-24-11-8-14-28(21-24)31(34)35)30(20-15-23-9-4-2-5-10-23)36-32(37)27-18-16-26(17-19-27)25-12-6-3-7-13-25/h2,4-5,8-11,14-21,25,29-30H,3,6-7,12-13,22H2,1H3,(H3,34,35)(H,36,37)/b20-15+ DZTHNMBIWFXTLC-HMMYKYKNSA-N 50062685 (E)-2-(3-Carbamimidoyl-benzyl)-3-(4-cyclohexyl-benzoylamino)-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL139008 Coagulation factor X Homo sapiens 580 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062685&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359352 103958207 CHEMBL139008 ZINC36140637 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107133 CCOc1cccc(c1)-c1ccc(cc1)C(=O)NC(\C=C\c1ccccc1)C(Cc1cccc(c1)C(N)=N)C(=O)OC InChI=1S/C35H35N3O4/c1-3-42-30-14-8-12-28(23-30)26-16-18-27(19-17-26)34(39)38-32(20-15-24-9-5-4-6-10-24)31(35(40)41-2)22-25-11-7-13-29(21-25)33(36)37/h4-21,23,31-32H,3,22H2,1-2H3,(H3,36,37)(H,38,39)/b20-15+ PPBGNSZPDCEZLQ-HMMYKYKNSA-N 50062688 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(3'-ethoxy-biphenyl-4-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL139810 Coagulation factor X Homo sapiens 180 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062688&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708066 103958210 CHEMBL139810 ZINC27517417 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107134 NC(=N)c1cccc(CC(CO)C(NC(=O)c2ccc(cc2)-c2ccccc2)\C=C\c2ccccc2)c1 InChI=1S/C32H31N3O2/c33-31(34)28-13-7-10-24(20-28)21-29(22-36)30(19-14-23-8-3-1-4-9-23)35-32(37)27-17-15-26(16-18-27)25-11-5-2-6-12-25/h1-20,29-30,36H,21-22H2,(H3,33,34)(H,35,37)/b19-14+ DJRCYKRRZXJXEI-XMHGGMMESA-N 50062686 Biphenyl-4-carboxylic acid {(E)-1-[2-(3-carbamimidoyl-phenyl)-1-hydroxymethyl-ethyl]-3-phenyl-allyl}-amide::CHEMBL434807 Coagulation factor X Homo sapiens 650 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062686&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20707929 103958208 CHEMBL434807 ZINC27521985 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107135 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(cc1)-c1ccc(OC)c(OC)c1)\C=C\c1ccccc1 InChI=1S/C35H35N3O5/c1-41-31-19-17-27(22-32(31)42-2)25-13-15-26(16-14-25)34(39)38-30(18-12-23-8-5-4-6-9-23)29(35(40)43-3)21-24-10-7-11-28(20-24)33(36)37/h4-20,22,29-30H,21H2,1-3H3,(H3,36,37)(H,38,39)/b18-12+ AAXSMTSTCQSEEA-LDADJPATSA-N 50062689 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(3',4'-dimethoxy-biphenyl-4-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL341970 Coagulation factor X Homo sapiens 30 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062689&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10257580 103958211 CHEMBL341970 ZINC27519020 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107136 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccccc1C)\C=C\c1ccccc1 InChI=1S/C28H29N3O3/c1-19-9-6-7-14-23(19)27(32)31-25(16-15-20-10-4-3-5-11-20)24(28(33)34-2)18-21-12-8-13-22(17-21)26(29)30/h3-17,24-25H,18H2,1-2H3,(H3,29,30)(H,31,32)/b16-15+ QKJGJPYSYJQOIN-FOCLMDBBSA-N 50062687 (E)-2-(3-Carbamimidoyl-benzyl)-3-(2-methyl-benzoylamino)-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL137866 Coagulation factor X Homo sapiens 1200 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062687&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708041 103958209 CHEMBL137866 ZINC27519715 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107138 COC(=O)[C@H](Cc1cccc(c1)C(N)=N)[C@H](NC(=O)c1ccccc1)\C=C\c1ccccc1 InChI=1S/C27H27N3O3/c1-33-27(32)23(18-20-11-8-14-22(17-20)25(28)29)24(16-15-19-9-4-2-5-10-19)30-26(31)21-12-6-3-7-13-21/h2-17,23-24H,18H2,1H3,(H3,28,29)(H,30,31)/b16-15+/t23-,24-/m1/s1 ZMOPMAIWSBRIMS-KDBREVJYSA-N 50062691 (E)-(2R,3R)-3-Benzoylamino-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL138704 Coagulation factor X Homo sapiens 700 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062691&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10721501 103958213 CHEMBL138704 ZINC13777676 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107139 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)C1CCC(CC1)C1CCCCC1)\C=C\c1ccccc1 InChI=1S/C33H43N3O3/c1-39-33(38)29(22-24-11-8-14-28(21-24)31(34)35)30(20-15-23-9-4-2-5-10-23)36-32(37)27-18-16-26(17-19-27)25-12-6-3-7-13-25/h2,4-5,8-11,14-15,20-21,25-27,29-30H,3,6-7,12-13,16-19,22H2,1H3,(H3,34,35)(H,36,37)/b20-15+ JNGAIJYLBCTUCM-HMMYKYKNSA-N 50062692 (E)-3-[(Bicyclohexyl-4-carbonyl)-amino]-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL138378 Coagulation factor X Homo sapiens 1120 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062692&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359648 103958214 CHEMBL138378 ZINC40496714 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107144 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(Oc2ccccc2)cc1)\C=C\c1ccccc1 InChI=1S/C33H31N3O4/c1-39-33(38)29(22-24-11-8-12-26(21-24)31(34)35)30(20-15-23-9-4-2-5-10-23)36-32(37)25-16-18-28(19-17-25)40-27-13-6-3-7-14-27/h2-21,29-30H,22H2,1H3,(H3,34,35)(H,36,37)/b20-15+ LDQMDDWSQPMVAZ-HMMYKYKNSA-N 50062696 (E)-2-(3-Carbamimidoyl-benzyl)-3-(4-phenoxy-benzoylamino)-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL140293 Coagulation factor X Homo sapiens 1220 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062696&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359353 103958218 CHEMBL140293 ZINC36140643 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107146 CC(=O)OCC(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(cc1)-c1ccccc1)\C=C\c1ccccc1 InChI=1S/C34H33N3O3/c1-24(38)40-23-31(22-26-11-8-14-30(21-26)33(35)36)32(20-15-25-9-4-2-5-10-25)37-34(39)29-18-16-28(17-19-29)27-12-6-3-7-13-27/h2-21,31-32H,22-23H2,1H3,(H3,35,36)(H,37,39)/b20-15+ LSDCEJWALDHZKK-HMMYKYKNSA-N 50062693 Acetic acid (E)-3-[(biphenyl-4-carbonyl)-amino]-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enyl ester::CHEMBL138217 Coagulation factor X Homo sapiens 360 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062693&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359626 103958215 CHEMBL138217 ZINC34689171 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107147 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(cc1)-c1ccccc1OC)\C=C\c1ccccc1 InChI=1S/C34H33N3O4/c1-40-31-14-7-6-13-28(31)25-16-18-26(19-17-25)33(38)37-30(20-15-23-9-4-3-5-10-23)29(34(39)41-2)22-24-11-8-12-27(21-24)32(35)36/h3-21,29-30H,22H2,1-2H3,(H3,35,36)(H,37,38)/b20-15+ AINQVQKSQFDZMT-HMMYKYKNSA-N 50062698 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(2'-methoxy-biphenyl-4-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL138258 Coagulation factor X Homo sapiens 50 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062698&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708058 103958220 CHEMBL138258 ZINC34689167 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107154 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1cccc(C)c1)\C=C\c1ccccc1 InChI=1S/C28H29N3O3/c1-19-8-6-13-23(16-19)27(32)31-25(15-14-20-9-4-3-5-10-20)24(28(33)34-2)18-21-11-7-12-22(17-21)26(29)30/h3-17,24-25H,18H2,1-2H3,(H3,29,30)(H,31,32)/b15-14+ CXMYVFCHMOZRRY-CCEZHUSRSA-N 50062705 (E)-2-(3-Carbamimidoyl-benzyl)-3-(3-methyl-benzoylamino)-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL343772 Coagulation factor X Homo sapiens 1100 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062705&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708044 103958227 CHEMBL343772 ZINC27519711 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107156 CCc1ccc(cc1)-c1ccc(cc1)C(=O)NC(\C=C\c1ccccc1)C(Cc1cccc(c1)C(N)=N)C(=O)OC InChI=1S/C35H35N3O3/c1-3-24-12-15-27(16-13-24)28-17-19-29(20-18-28)34(39)38-32(21-14-25-8-5-4-6-9-25)31(35(40)41-2)23-26-10-7-11-30(22-26)33(36)37/h4-22,31-32H,3,23H2,1-2H3,(H3,36,37)(H,38,39)/b21-14+ FLCFXXDYBIGOAA-KGENOOAVSA-N 50062702 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(4'-ethyl-biphenyl-4-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL336440 Coagulation factor X Homo sapiens 890 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062702&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708074 103958224 CHEMBL336440 ZINC27519431 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107157 COC(=O)[C@@H](Cc1cccc(c1)C(N)=N)[C@H](NC(=O)c1ccccc1)\C=C\c1ccccc1 InChI=1S/C27H27N3O3/c1-33-27(32)23(18-20-11-8-14-22(17-20)25(28)29)24(16-15-19-9-4-2-5-10-19)30-26(31)21-12-6-3-7-13-21/h2-17,23-24H,18H2,1H3,(H3,28,29)(H,30,31)/b16-15+/t23-,24+/m0/s1 ZMOPMAIWSBRIMS-PMZGJIOCSA-N 50062703 (E)-(2S,3R)-3-Benzoylamino-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL140987 Coagulation factor X Homo sapiens 2000 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062703&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10530789 103958225 CHEMBL140987 ZINC27520236 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107160 COCC(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(cc1)-c1ccccc1)\C=C\c1ccccc1 InChI=1S/C33H33N3O2/c1-38-23-30(22-25-11-8-14-29(21-25)32(34)35)31(20-15-24-9-4-2-5-10-24)36-33(37)28-18-16-27(17-19-28)26-12-6-3-7-13-26/h2-21,30-31H,22-23H2,1H3,(H3,34,35)(H,36,37)/b20-15+ ZWTFULMWPLLWNJ-HMMYKYKNSA-N 50062695 Biphenyl-4-carboxylic acid {(E)-1-[2-(3-carbamimidoyl-phenyl)-1-methoxymethyl-ethyl]-3-phenyl-allyl}-amide::CHEMBL422819 Coagulation factor X Homo sapiens 540 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062695&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708219 103958217 CHEMBL422819 ZINC34689172 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107161 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccccc1)\C=C\c1ccccc1 InChI=1S/C27H27N3O3/c1-33-27(32)23(18-20-11-8-14-22(17-20)25(28)29)24(16-15-19-9-4-2-5-10-19)30-26(31)21-12-6-3-7-13-21/h2-17,23-24H,18H2,1H3,(H3,28,29)(H,30,31)/b16-15+ ZMOPMAIWSBRIMS-FOCLMDBBSA-N 50062704 (E)-3-Benzoylamino-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL344149 Coagulation factor X Homo sapiens 700 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062704&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708094 103958226 CHEMBL344149 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107163 COC(=O)C(Cc1cccc(c1)C(N)=N)C(CCc1ccccc1)NC(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C33H33N3O3/c1-39-33(38)29(22-24-11-8-14-28(21-24)31(34)35)30(20-15-23-9-4-2-5-10-23)36-32(37)27-18-16-26(17-19-27)25-12-6-3-7-13-25/h2-14,16-19,21,29-30H,15,20,22H2,1H3,(H3,34,35)(H,36,37) JFZUBUPLMKFLQR-UHFFFAOYSA-N 50062682 3-[(Biphenyl-4-carbonyl)-amino]-2-(3-carbamimidoyl-benzyl)-5-phenyl-pentanoic acid methyl ester::CHEMBL141532 Coagulation factor X Homo sapiens 60.0 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062682&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708107 103958204 CHEMBL141532 ZINC27520443 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107165 CN(C)C(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(cc1)-c1ccccc1)\C=C\c1ccccc1 InChI=1S/C34H34N4O2/c1-38(2)34(40)30(23-25-12-9-15-29(22-25)32(35)36)31(21-16-24-10-5-3-6-11-24)37-33(39)28-19-17-27(18-20-28)26-13-7-4-8-14-26/h3-22,30-31H,23H2,1-2H3,(H3,35,36)(H,37,39)/b21-16+ SDQYFCQKLHFFCE-LTGZKZEYSA-N 50062706 Biphenyl-4-carboxylic acid {(E)-1-[2-(3-carbamimidoyl-phenyl)-1-dimethylcarbamoyl-ethyl]-3-phenyl-allyl}-amide::CHEMBL141164 Coagulation factor X Homo sapiens 4400 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062706&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359609 103958228 CHEMBL141164 ZINC36140670 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107166 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(cc1)-c1ccccc1C)\C=C\c1ccccc1 InChI=1S/C34H33N3O3/c1-23-9-6-7-14-29(23)26-16-18-27(19-17-26)33(38)37-31(20-15-24-10-4-3-5-11-24)30(34(39)40-2)22-25-12-8-13-28(21-25)32(35)36/h3-21,30-31H,22H2,1-2H3,(H3,35,36)(H,37,38)/b20-15+ FMTGTQYIPPNOGJ-HMMYKYKNSA-N 50062681 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(2'-methyl-biphenyl-4-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL138299 Coagulation factor X Homo sapiens 90 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062681&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708079 103958203 CHEMBL138299 ZINC36107630 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107167 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1cccc2ccccc12)\C=C\c1ccccc1 InChI=1S/C31H29N3O3/c1-37-31(36)27(20-22-11-7-14-24(19-22)29(32)33)28(18-17-21-9-3-2-4-10-21)34-30(35)26-16-8-13-23-12-5-6-15-25(23)26/h2-19,27-28H,20H2,1H3,(H3,32,33)(H,34,35)/b18-17+ ICPWQNURJPTVSL-ISLYRVAYSA-N 50062707 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(naphthalene-1-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL344205 Coagulation factor X Homo sapiens 790.0 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062707&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708098 103958229 CHEMBL344205 ZINC36140664 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107169 NC(=N)c1cccc(CC(C(NC(=O)c2ccc(cc2)-c2ccccc2)\C=C\c2ccccc2)C(O)=O)c1 InChI=1S/C32H29N3O3/c33-30(34)27-13-7-10-23(20-27)21-28(32(37)38)29(19-14-22-8-3-1-4-9-22)35-31(36)26-17-15-25(16-18-26)24-11-5-2-6-12-24/h1-20,28-29H,21H2,(H3,33,34)(H,35,36)(H,37,38)/b19-14+ BMFFYWXKKIEIIA-XMHGGMMESA-N 50062694 (E)-3-[(Biphenyl-4-carbonyl)-amino]-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enoic acid::CHEMBL140093 Coagulation factor X Homo sapiens 2700 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062694&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20707927 103958216 CHEMBL140093 ZINC27521991 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107171 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(cc1)-c1ccc(OC)cc1OC)\C=C\c1ccccc1 InChI=1S/C35H35N3O5/c1-41-28-17-18-29(32(22-28)42-2)25-13-15-26(16-14-25)34(39)38-31(19-12-23-8-5-4-6-9-23)30(35(40)43-3)21-24-10-7-11-27(20-24)33(36)37/h4-20,22,30-31H,21H2,1-3H3,(H3,36,37)(H,38,39)/b19-12+ YUSXAXXYSSHTFP-XDHOZWIPSA-N 50062713 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(2',4'-dimethoxy-biphenyl-4-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL137858 Coagulation factor X Homo sapiens 90 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062713&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359453 103958235 CHEMBL137858 ZINC36107631 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107174 CCc1cccc(c1)-c1ccc(cc1)C(=O)NC(\C=C\c1ccccc1)C(Cc1cccc(c1)C(N)=N)C(=O)OC InChI=1S/C35H35N3O3/c1-3-24-11-7-13-29(21-24)27-16-18-28(19-17-27)34(39)38-32(20-15-25-9-5-4-6-10-25)31(35(40)41-2)23-26-12-8-14-30(22-26)33(36)37/h4-22,31-32H,3,23H2,1-2H3,(H3,36,37)(H,38,39)/b20-15+ HMWXVRNYPUAKEU-HMMYKYKNSA-N 50062700 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(3'-ethyl-biphenyl-4-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL342211 Coagulation factor X Homo sapiens 390 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062700&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359598 103958222 CHEMBL342211 ZINC27520436 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107175 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)Cc1ccc(cc1)-c1ccccc1)\C=C\c1ccccc1 InChI=1S/C34H33N3O3/c1-40-34(39)30(22-26-11-8-14-29(21-26)33(35)36)31(20-17-24-9-4-2-5-10-24)37-32(38)23-25-15-18-28(19-16-25)27-12-6-3-7-13-27/h2-21,30-31H,22-23H2,1H3,(H3,35,36)(H,37,38)/b20-17+ VMQFABUDELJKAB-LVZFUZTISA-N 50062710 (E)-3-(2-Biphenyl-4-yl-acetylamino)-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL138398 Coagulation factor X Homo sapiens 1130 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062710&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359501 103958232 CHEMBL138398 ZINC34689169 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107176 CCc1ccccc1-c1ccc(cc1)C(=O)NC(\C=C\c1ccccc1)C(Cc1cccc(c1)C(N)=N)C(=O)OC InChI=1S/C35H35N3O3/c1-3-26-13-7-8-15-30(26)27-17-19-28(20-18-27)34(39)38-32(21-16-24-10-5-4-6-11-24)31(35(40)41-2)23-25-12-9-14-29(22-25)33(36)37/h4-22,31-32H,3,23H2,1-2H3,(H3,36,37)(H,38,39)/b21-16+ KJRMSZFCCVITKM-LTGZKZEYSA-N 50062690 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(2'-ethyl-biphenyl-4-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL139084 Coagulation factor X Homo sapiens 380 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062690&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708056 103958212 CHEMBL139084 ZINC27519486 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107177 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(cc1)-c1cccc(OC)c1)\C=C\c1ccccc1 InChI=1S/C34H33N3O4/c1-40-29-13-7-11-27(22-29)25-15-17-26(18-16-25)33(38)37-31(19-14-23-8-4-3-5-9-23)30(34(39)41-2)21-24-10-6-12-28(20-24)32(35)36/h3-20,22,30-31H,21H2,1-2H3,(H3,35,36)(H,37,38)/b19-14+ SRJFMCQYJFRTOX-XMHGGMMESA-N 50062712 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(3'-methoxy-biphenyl-4-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL139561 Coagulation factor X Homo sapiens 110 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062712&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708069 103958234 CHEMBL139561 ZINC36107653 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107178 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NS(=O)(=O)c1ccc(cc1)-c1ccccc1)\C=C\c1ccccc1 InChI=1S/C32H31N3O4S/c1-39-32(36)29(22-24-11-8-14-27(21-24)31(33)34)30(20-15-23-9-4-2-5-10-23)35-40(37,38)28-18-16-26(17-19-28)25-12-6-3-7-13-25/h2-21,29-30,35H,22H2,1H3,(H3,33,34)/b20-15+ GGBQHCPYXMONLA-HMMYKYKNSA-N 50062711 (E)-3-(Biphenyl-4-sulfonylamino)-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL138449 Coagulation factor X Homo sapiens 1970 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062711&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359487 103958233 CHEMBL138449 ZINC36140656 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107179 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(cc1)-c1ccccc1)\C=C\c1ccccc1 InChI=1S/C33H31N3O3/c1-39-33(38)29(22-24-11-8-14-28(21-24)31(34)35)30(20-15-23-9-4-2-5-10-23)36-32(37)27-18-16-26(17-19-27)25-12-6-3-7-13-25/h2-21,29-30H,22H2,1H3,(H3,34,35)(H,36,37)/b20-15+ CIJBLVOZDMZNJK-HMMYKYKNSA-N 50062697 (E)-3-[(Biphenyl-4-carbonyl)-amino]-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL138610 Coagulation factor X Homo sapiens 110 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062697&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708106 103958219 CHEMBL138610 ZINC36176492 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107181 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(cc1)-c1ccc(C)cc1)\C=C\c1ccccc1 InChI=1S/C34H33N3O3/c1-23-11-14-26(15-12-23)27-16-18-28(19-17-27)33(38)37-31(20-13-24-7-4-3-5-8-24)30(34(39)40-2)22-25-9-6-10-29(21-25)32(35)36/h3-21,30-31H,22H2,1-2H3,(H3,35,36)(H,37,38)/b20-13+ LPFASJPXYLLRNZ-DEDYPNTBSA-N 50062684 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(4'-methyl-biphenyl-4-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL344831 Coagulation factor X Homo sapiens 240 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062684&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708108 103958206 CHEMBL344831 ZINC36107627 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107182 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(cc1)-c1ccc(OC)cc1)\C=C\c1ccccc1 InChI=1S/C34H33N3O4/c1-40-29-18-16-26(17-19-29)25-12-14-27(15-13-25)33(38)37-31(20-11-23-7-4-3-5-8-23)30(34(39)41-2)22-24-9-6-10-28(21-24)32(35)36/h3-21,30-31H,22H2,1-2H3,(H3,35,36)(H,37,38)/b20-11+ GUMNUIVKTFMZDK-RGVLZGJSSA-N 50062708 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(4'-methoxy-biphenyl-4-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL342831 Coagulation factor X Homo sapiens 80 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062708&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359454 103958230 CHEMBL342831 ZINC36107633 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107183 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc2ccccc2c1)\C=C\c1ccccc1 InChI=1S/C31H29N3O3/c1-37-31(36)27(19-22-10-7-13-25(18-22)29(32)33)28(17-14-21-8-3-2-4-9-21)34-30(35)26-16-15-23-11-5-6-12-24(23)20-26/h2-18,20,27-28H,19H2,1H3,(H3,32,33)(H,34,35)/b17-14+ GCGIDZQFZLNYTE-SAPNQHFASA-N 50062715 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(naphthalene-2-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL138063 Coagulation factor X Homo sapiens 160 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062715&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708099 103958237 CHEMBL138063 ZINC36140660 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107184 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(Cc2ccccc2)cc1)\C=C\c1ccccc1 InChI=1S/C34H33N3O3/c1-40-34(39)30(23-27-13-8-14-29(22-27)32(35)36)31(20-17-24-9-4-2-5-10-24)37-33(38)28-18-15-26(16-19-28)21-25-11-6-3-7-12-25/h2-20,22,30-31H,21,23H2,1H3,(H3,35,36)(H,37,38)/b20-17+ XLNGIGRIGVQMIN-LVZFUZTISA-N 50062716 (E)-3-(4-Benzyl-benzoylamino)-2-(3-carbamimidoyl-benzyl)-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL139105 Coagulation factor X Homo sapiens 460 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062716&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359354 103958238 CHEMBL139105 ZINC36140649 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107188 COC(=O)[C@H](Cc1cccc(c1)C(N)=N)[C@@H](CCc1ccccc1)NC(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C33H33N3O3/c1-39-33(38)29(22-24-11-8-14-28(21-24)31(34)35)30(20-15-23-9-4-2-5-10-23)36-32(37)27-18-16-26(17-19-27)25-12-6-3-7-13-25/h2-14,16-19,21,29-30H,15,20,22H2,1H3,(H3,34,35)(H,36,37)/t29-,30-/m1/s1 JFZUBUPLMKFLQR-LOYHVIPDSA-N 50062714 (2R,3R)-3-[(Biphenyl-4-carbonyl)-amino]-2-(3-carbamimidoyl-benzyl)-5-phenyl-pentanoic acid methyl ester::CHEMBL45407 Coagulation factor X Homo sapiens 60 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062714&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10556031 103958236 CHEMBL45407 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107191 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(cc1)-c1cccc(C)c1)\C=C\c1ccccc1 InChI=1S/C34H33N3O3/c1-23-8-6-12-28(20-23)26-15-17-27(18-16-26)33(38)37-31(19-14-24-9-4-3-5-10-24)30(34(39)40-2)22-25-11-7-13-29(21-25)32(35)36/h3-21,30-31H,22H2,1-2H3,(H3,35,36)(H,37,38)/b19-14+ JVEIHEXJFKDWES-XMHGGMMESA-N 50062683 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(3'-methyl-biphenyl-4-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL341997 Coagulation factor X Homo sapiens 120 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062683&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708078 103958205 CHEMBL341997 ZINC36107629 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107193 CCOc1ccc(cc1)-c1ccc(cc1)C(=O)NC(\C=C\c1ccccc1)C(Cc1cccc(c1)C(N)=N)C(=O)OC InChI=1S/C35H35N3O4/c1-3-42-30-19-17-27(18-20-30)26-13-15-28(16-14-26)34(39)38-32(21-12-24-8-5-4-6-9-24)31(35(40)41-2)23-25-10-7-11-29(22-25)33(36)37/h4-22,31-32H,3,23H2,1-2H3,(H3,36,37)(H,38,39)/b21-12+ VMQAFJPSEXTGNA-CIAFOILYSA-N 50062701 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(4'-ethoxy-biphenyl-4-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL140719 Coagulation factor X Homo sapiens 360 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062701&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708073 103958223 CHEMBL140719 ZINC27520183 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107194 CCOc1ccccc1-c1ccc(cc1)C(=O)NC(\C=C\c1ccccc1)C(Cc1cccc(c1)C(N)=N)C(=O)OC InChI=1S/C35H35N3O4/c1-3-42-32-15-8-7-14-29(32)26-17-19-27(20-18-26)34(39)38-31(21-16-24-10-5-4-6-11-24)30(35(40)41-2)23-25-12-9-13-28(22-25)33(36)37/h4-22,30-31H,3,23H2,1-2H3,(H3,36,37)(H,38,39)/b21-16+ RBJXGXOXVKHFAX-LTGZKZEYSA-N 50062709 (E)-2-(3-Carbamimidoyl-benzyl)-3-[(2'-ethoxy-biphenyl-4-carbonyl)-amino]-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL341808 Coagulation factor X Homo sapiens 60 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062709&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 20708055 103958231 CHEMBL341808 ZINC27517421 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107195 COC(=O)C(Cc1cccc(c1)C(N)=N)C(NC(=O)c1ccc(C)cc1)\C=C\c1ccccc1 InChI=1S/C28H29N3O3/c1-19-11-14-22(15-12-19)27(32)31-25(16-13-20-7-4-3-5-8-20)24(28(33)34-2)18-21-9-6-10-23(17-21)26(29)30/h3-17,24-25H,18H2,1-2H3,(H3,29,30)(H,31,32)/b16-13+ WARQBRAPFLKGEM-DTQAZKPQSA-N 50062717 (E)-2-(3-Carbamimidoyl-benzyl)-3-(4-methyl-benzoylamino)-5-phenyl-pent-4-enoic acid methyl ester::CHEMBL141983 Coagulation factor X Homo sapiens 600 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062717&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44359621 103958239 CHEMBL141983 ZINC27521837 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50107199 NC(=N)c1cccc(CCC(NC(=O)c2ccc(cc2)-c2ccccc2)\C=C\c2ccccc2)c1 InChI=1S/C31H29N3O/c32-30(33)28-13-7-10-24(22-28)15-21-29(20-14-23-8-3-1-4-9-23)34-31(35)27-18-16-26(17-19-27)25-11-5-2-6-12-25/h1-14,16-20,22,29H,15,21H2,(H3,32,33)(H,34,35)/b20-14+ BMXLIXIFYFUVHD-XSFVSMFZSA-N 50062699 Biphenyl-4-carboxylic acid {(E)-1-[2-(3-carbamimidoyl-phenyl)-ethyl]-3-phenyl-allyl}-amide::CHEMBL343568 Coagulation factor X Homo sapiens 950.0 ChEMBL 10.1021/jm970482y 10.7270/Q28W3CFK 9484495 Klein, SI; Czekaj, M; Gardner, CJ; Guertin, KR; Cheney, DL; Spada, AP; Bolton, SA; Brown, K; Colussi, D; Heran, CL; Morgan, SR; Leadley, RJ; Dunwiddie, CT; Perrone, MH; Chu, V Collegeville http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062699&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10647609 103958221 CHEMBL343568 ZINC27520444 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105601 NC(=N)c1ccc(CCC(CC(O)=O)c2cccc(c2)C(N)=N)cc1 InChI=1S/C19H22N4O2/c20-18(21)13-7-4-12(5-8-13)6-9-15(11-17(24)25)14-2-1-3-16(10-14)19(22)23/h1-5,7-8,10,15H,6,9,11H2,(H3,20,21)(H3,22,23)(H,24,25) CZMBCKCIGRXHMR-UHFFFAOYSA-N 50062022 5-(4-Carbamimidoyl-phenyl)-3-(3-carbamimidoyl-phenyl)-pentanoic acid::CHEMBL347586 Coagulation factor X Homo sapiens 1400 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062022&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10806942 103957570 CHEMBL347586 ZINC13776608 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105604 COC(=O)CC(CCc1ccc(cc1)C(=O)OC)c1cccc(c1)C(N)=N InChI=1S/C21H24N2O4/c1-26-19(24)13-17(16-4-3-5-18(12-16)20(22)23)11-8-14-6-9-15(10-7-14)21(25)27-2/h3-7,9-10,12,17H,8,11,13H2,1-2H3,(H3,22,23) YJHQJYCQSFPDGI-UHFFFAOYSA-N 50062019 4-[3-(3-Carbamimidoyl-phenyl)-4-methoxycarbonyl-butyl]-benzoic acid methyl ester::CHEMBL156043 Coagulation factor X Homo sapiens 2800 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062019&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10595198 103957567 CHEMBL156043 ZINC13776591 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105605 CC(C)OC(=O)CC(CCc1ccc(cc1)C(N)=N)c1cccc(c1)C(N)=N InChI=1S/C22H28N4O2/c1-14(2)28-20(27)13-18(17-4-3-5-19(12-17)22(25)26)11-8-15-6-9-16(10-7-15)21(23)24/h3-7,9-10,12,14,18H,8,11,13H2,1-2H3,(H3,23,24)(H3,25,26) GDEYPAOKQJBBOZ-UHFFFAOYSA-N 50062024 5-(4-Carbamimidoyl-phenyl)-3-(3-carbamimidoyl-phenyl)-pentanoic acid isopropyl ester::CHEMBL439642 Coagulation factor X Homo sapiens 192 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062024&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10571832 103957572 CHEMBL439642 ZINC13776612 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105609 CCOC(=O)CC(CCc1cccc(c1)C(N)=N)c1ccc(cc1)C(N)=N InChI=1S/C21H26N4O2/c1-2-27-19(26)13-17(15-8-10-16(11-9-15)20(22)23)7-6-14-4-3-5-18(12-14)21(24)25/h3-5,8-12,17H,2,6-7,13H2,1H3,(H3,22,23)(H3,24,25) IVWHZXFNFUVNTJ-UHFFFAOYSA-N 50062028 5-(3-Carbamimidoyl-phenyl)-3-(4-carbamimidoyl-phenyl)-pentanoic acid ethyl ester::CHEMBL158207 Coagulation factor X Homo sapiens 1642 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062028&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10570938 103957576 CHEMBL158207 ZINC13776587 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105612 NC(=N)c1ccc(CCC(=O)c2cccc(c2)C(N)=N)cc1 InChI=1S/C17H18N4O/c18-16(19)12-7-4-11(5-8-12)6-9-15(22)13-2-1-3-14(10-13)17(20)21/h1-5,7-8,10H,6,9H2,(H3,18,19)(H3,20,21) KKNROWNQSDBWFT-UHFFFAOYSA-N 50062030 1-[3-amino(imino)methylphenyl]-3-[4-amino(imino)methylphenyl]-1-propanone::CHEMBL157601 Coagulation factor X Homo sapiens 5100 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062030&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10661464 103957578 CHEMBL157601 ZINC13776576 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105621 CCOC(=O)CC(CCc1ccccc1)c1cccc(c1)C(N)=N InChI=1S/C20H24N2O2/c1-2-24-19(23)14-17(12-11-15-7-4-3-5-8-15)16-9-6-10-18(13-16)20(21)22/h3-10,13,17H,2,11-12,14H2,1H3,(H3,21,22) TYUUTJJTPOUFJK-UHFFFAOYSA-N 50062021 3-(3-Carbamimidoyl-phenyl)-5-phenyl-pentanoic acid ethyl ester::CHEMBL435638 Coagulation factor X Homo sapiens 2900 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062021&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44371477 103957569 CHEMBL435638 ZINC27710289 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105623 COC(=O)CC(CCc1ccc(cc1)C(N)=N)c1cccc(c1)C(N)=N InChI=1S/C20H24N4O2/c1-26-18(25)12-16(15-3-2-4-17(11-15)20(23)24)10-7-13-5-8-14(9-6-13)19(21)22/h2-6,8-9,11,16H,7,10,12H2,1H3,(H3,21,22)(H3,23,24) PVALLOSAENRPQO-UHFFFAOYSA-N 50062035 5-(4-Carbamimidoyl-phenyl)-3-(3-carbamimidoyl-phenyl)-pentanoic acid methyl ester::CHEMBL156702::CHEMBL317923 Coagulation factor X Homo sapiens 34 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062035&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search IN4 1AZ8 1308 103957583 CHEMBL156702CHEMBL317923 ZINC03870450 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105624 COC(=O)CC(CCc1ccc(NS(C)(=O)=O)cc1)c1cccc(c1)C(N)=N InChI=1S/C20H25N3O4S/c1-27-19(24)13-16(15-4-3-5-17(12-15)20(21)22)9-6-14-7-10-18(11-8-14)23-28(2,25)26/h3-5,7-8,10-12,16,23H,6,9,13H2,1-2H3,(H3,21,22) JRVSMBQXSSFFJC-UHFFFAOYSA-N 50062031 3-(3-Carbamimidoyl-phenyl)-5-(4-methanesulfonylamino-phenyl)-pentanoic acid methyl ester::CHEMBL436026 Coagulation factor X Homo sapiens 654 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062031&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10621200 103957579 CHEMBL436026 ZINC13776594 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105625 NC(=N)c1ccc(CCC(CC(=O)n2cccc2)c2cccc(c2)C(N)=N)cc1 InChI=1S/C23H25N5O/c24-22(25)17-9-6-16(7-10-17)8-11-19(15-21(29)28-12-1-2-13-28)18-4-3-5-20(14-18)23(26)27/h1-7,9-10,12-14,19H,8,11,15H2,(H3,24,25)(H3,26,27) BUCDGKAYINVMCV-UHFFFAOYSA-N 50062037 3-[3-amino(imino)methylphenyl]-5-[4-amino(imino)methylphenyl]-1-(1H-1-pyrrolyl)-1-pentanone::CHEMBL158063 Coagulation factor X Homo sapiens 1150 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062037&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10715258 103957585 CHEMBL158063 ZINC36107661 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105630 COC(=O)CC(CCCCc1ccc(cc1)N=C(N)N)c1cccc(c1)C(N)=N InChI=1S/C22H29N5O2/c1-29-20(28)14-17(16-7-4-8-18(13-16)21(23)24)6-3-2-5-15-9-11-19(12-10-15)27-22(25)26/h4,7-13,17H,2-3,5-6,14H2,1H3,(H3,23,24)(H4,25,26,27) FKTIPOLHKSMAHY-UHFFFAOYSA-N 50062038 3-(3-Carbamimidoyl-phenyl)-7-(4-guanidino-phenyl)-heptanoic acid methyl ester::CHEMBL351329 Coagulation factor X Homo sapiens 57 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062038&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10250104 103957586 CHEMBL351329 ZINC13776606 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105631 CNC(=O)CC(CCc1ccc(cc1)C(N)=N)c1cccc(c1)C(N)=N InChI=1S/C20H25N5O/c1-25-18(26)12-16(15-3-2-4-17(11-15)20(23)24)10-7-13-5-8-14(9-6-13)19(21)22/h2-6,8-9,11,16H,7,10,12H2,1H3,(H3,21,22)(H3,23,24)(H,25,26) HJNUQOATQYFGFP-UHFFFAOYSA-N 50062036 5-(4-Carbamimidoyl-phenyl)-3-(3-carbamimidoyl-phenyl)-pentanoic acid methylamide::CHEMBL156472 Coagulation factor X Homo sapiens 940 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062036&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10569959 103957584 CHEMBL156472 ZINC13776614 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105635 COC(=O)CNC(=O)CC(CCc1ccc(cc1)C(N)=N)c1cccc(c1)C(N)=N InChI=1S/C22H27N5O3/c1-30-20(29)13-27-19(28)12-17(16-3-2-4-18(11-16)22(25)26)10-7-14-5-8-15(9-6-14)21(23)24/h2-6,8-9,11,17H,7,10,12-13H2,1H3,(H3,23,24)(H3,25,26)(H,27,28) DCPMEELYWLPZBO-UHFFFAOYSA-N 50062029 CHEMBL155632::[5-(4-Carbamimidoyl-phenyl)-3-(3-carbamimidoyl-phenyl)-pentanoylamino]-acetic acid methyl ester Coagulation factor X Homo sapiens 2400 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062029&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10716448 103957577 CHEMBL155632 ZINC13776616 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105639 COC(=O)CC(CCc1ccc(cc1)N=C(N)N)c1cccc(c1)C(N)=N InChI=1S/C20H25N5O2/c1-27-18(26)12-15(14-3-2-4-16(11-14)19(21)22)8-5-13-6-9-17(10-7-13)25-20(23)24/h2-4,6-7,9-11,15H,5,8,12H2,1H3,(H3,21,22)(H4,23,24,25) CUWCNEISAWREFU-UHFFFAOYSA-N 50062027 3-(3-Carbamimidoyl-phenyl)-5-(4-guanidino-phenyl)-pentanoic acid methyl ester::CHEMBL156161 Coagulation factor X Homo sapiens 9 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062027&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9929157 103957575 CHEMBL156161 ZINC13776605 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105640 COC(=O)CC(CCc1ccc(cc1)C(N)=O)c1cccc(c1)C(N)=N InChI=1S/C20H23N3O3/c1-26-18(24)12-16(15-3-2-4-17(11-15)19(21)22)10-7-13-5-8-14(9-6-13)20(23)25/h2-6,8-9,11,16H,7,10,12H2,1H3,(H3,21,22)(H2,23,25) RSOOCDJHZHAFLX-UHFFFAOYSA-N 50062034 3-(3-Carbamimidoyl-phenyl)-5-(4-carbamoyl-phenyl)-pentanoic acid methyl ester::CHEMBL155871 Coagulation factor X Homo sapiens 550 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062034&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10546004 103957582 CHEMBL155871 ZINC13776602 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105641 CCOC(=O)CC(CCc1ccc(cc1)C(N)=N)c1ccccc1 InChI=1S/C20H24N2O2/c1-2-24-19(23)14-18(16-6-4-3-5-7-16)13-10-15-8-11-17(12-9-15)20(21)22/h3-9,11-12,18H,2,10,13-14H2,1H3,(H3,21,22) WMUAWLXKXOZNPA-UHFFFAOYSA-N 50062032 5-(4-Carbamimidoyl-phenyl)-3-phenyl-pentanoic acid ethyl ester::CHEMBL346543 Coagulation factor X Homo sapiens >30000 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062032&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10543987 103957580 CHEMBL346543 ZINC27706053 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105643 COC(=O)CC(CCc1ccc(NS(=O)(=O)c2ccccc2)cc1)c1cccc(c1)C(N)=N InChI=1S/C25H27N3O4S/c1-32-24(29)17-20(19-6-5-7-21(16-19)25(26)27)13-10-18-11-14-22(15-12-18)28-33(30,31)23-8-3-2-4-9-23/h2-9,11-12,14-16,20,28H,10,13,17H2,1H3,(H3,26,27) GKIMFPDOQSVZBN-UHFFFAOYSA-N 50062023 5-(4-Benzenesulfonylamino-phenyl)-3-(3-carbamimidoyl-phenyl)-pentanoic acid methyl ester::CHEMBL348038 Coagulation factor X Homo sapiens 1100 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062023&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10504366 103957571 CHEMBL348038 ZINC13776598 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105647 CONC(=O)CC(CCc1ccc(cc1)C(N)=N)c1cccc(c1)C(N)=N InChI=1S/C20H25N5O2/c1-27-25-18(26)12-16(15-3-2-4-17(11-15)20(23)24)10-7-13-5-8-14(9-6-13)19(21)22/h2-6,8-9,11,16H,7,10,12H2,1H3,(H3,21,22)(H3,23,24)(H,25,26) WUQUCNJVVCEYPG-UHFFFAOYSA-N 50062025 5-(4-Carbamimidoyl-phenyl)-3-(3-carbamimidoyl-phenyl)-pentanoic acid methoxy-amide::CHEMBL347640 Coagulation factor X Homo sapiens 2400 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062025&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10761484 103957573 CHEMBL347640 ZINC13776617 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105648 CCOC(=O)CC(CCc1ccc(cc1)C(N)=N)c1cccc(c1)C(N)=N InChI=1S/C21H26N4O2/c1-2-27-19(26)13-17(16-4-3-5-18(12-16)21(24)25)11-8-14-6-9-15(10-7-14)20(22)23/h3-7,9-10,12,17H,2,8,11,13H2,1H3,(H3,22,23)(H3,24,25) ZGOHPVFFWMLVKD-UHFFFAOYSA-N 50062033 5-(4-Carbamimidoyl-phenyl)-3-(3-carbamimidoyl-phenyl)-pentanoic acid ethyl ester::CHEMBL155820 Coagulation factor X Homo sapiens 42 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062033&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9907201 103957581 CHEMBL155820 ZINC13776610 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105649 COC(=O)CC(CCc1ccc(N)cc1)c1cccc(c1)C(N)=N InChI=1S/C19H23N3O2/c1-24-18(23)12-15(8-5-13-6-9-17(20)10-7-13)14-3-2-4-16(11-14)19(21)22/h2-4,6-7,9-11,15H,5,8,12,20H2,1H3,(H3,21,22) HVOVFAYWILWKPI-UHFFFAOYSA-N 50062026 5-(4-Amino-phenyl)-3-(3-carbamimidoyl-phenyl)-pentanoic acid methyl ester::CHEMBL156765 Coagulation factor X Homo sapiens 5000 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062026&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10592155 103957574 CHEMBL156765 ZINC13776604 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105651 CCOC(=O)CC(CCc1ccc(cc1)C(N)=N)c1ccc(cc1)C(N)=N InChI=1S/C21H26N4O2/c1-2-27-19(26)13-18(15-9-11-17(12-10-15)21(24)25)8-5-14-3-6-16(7-4-14)20(22)23/h3-4,6-7,9-12,18H,2,5,8,13H2,1H3,(H3,22,23)(H3,24,25) YFFCSWPASKXTLR-UHFFFAOYSA-N 50062020 3,5-Bis-(4-carbamimidoyl-phenyl)-pentanoic acid ethyl ester::CHEMBL156578 Coagulation factor X Homo sapiens 22900 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062020&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10761427 103957568 CHEMBL156578 ZINC13776583 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50105652 COC(=O)CC(CCc1cccc(c1)C(N)=N)c1cccc(c1)C(N)=N InChI=1S/C20H24N4O2/c1-26-18(25)12-15(14-5-3-7-17(11-14)20(23)24)9-8-13-4-2-6-16(10-13)19(21)22/h2-7,10-11,15H,8-9,12H2,1H3,(H3,21,22)(H3,23,24) BJHNYPYYKUGEQS-UHFFFAOYSA-N 50062039 3,5-Bis-(3-carbamimidoyl-phenyl)-pentanoic acid methyl ester::CHEMBL156367 Coagulation factor X Homo sapiens 2800 ChEMBL 10.1021/jm970485a 10.7270/Q2R49PW5 9438022 Maduskuie, TP; McNamara, KJ; Ru, Y; Knabb, RM; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062039&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10784195 103957587 CHEMBL156367 ZINC13776585 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50016856 C\C(=C(/F)C(=O)Nc1ccc(cc1F)-c1ccccc1S(N)(=O)=O)c1ccc2ccnc(N)c2c1 InChI=1S/C25H20F2N4O3S/c1-14(16-7-6-15-10-11-30-24(28)19(15)12-16)23(27)25(32)31-21-9-8-17(13-20(21)26)18-4-2-3-5-22(18)35(29,33)34/h2-13H,1H3,(H2,28,30)(H,31,32)(H2,29,33,34)/b23-14+ FLCBADIIGVYFAJ-OEAKJJBVSA-N 50115935 (E)-3-(1-Amino-isoquinolin-7-yl)-2-fluoro-but-2-enoic acid (3-fluoro-2'-sulfamoyl-biphenyl-4-yl)-amide::CHEMBL62288 Coagulation factor X Homo sapiens 5 ChEMBL 10.1016/s0960-894x(02)00304-9 10.7270/Q2PZ584G 12113838 Song, Y; Clizbe, L; Bhakta, C; Teng, W; Li, W; Wong, P; Huang, B; Sinha, U; Park, G; Reed, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115935&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10323469 104009763 51689 CHEMBL62288 ZINC13444918 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50209924 C\C(=C(/F)C(=O)Nc1ccc(cc1Br)-c1ccccc1S(N)(=O)=O)c1ccc2ccnc(N)c2c1 InChI=1S/C25H20BrFN4O3S/c1-14(16-7-6-15-10-11-30-24(28)19(15)12-16)23(27)25(32)31-21-9-8-17(13-20(21)26)18-4-2-3-5-22(18)35(29,33)34/h2-13H,1H3,(H2,28,30)(H,31,32)(H2,29,33,34)/b23-14+ LWKKDTXFIYFHNG-OEAKJJBVSA-N 50115936 (E)-3-(1-Amino-isoquinolin-7-yl)-2-fluoro-but-2-enoic acid (3-bromo-2'-sulfamoyl-biphenyl-4-yl)-amide::CHEMBL63088 Coagulation factor X Homo sapiens 7 ChEMBL 10.1016/s0960-894x(02)00304-9 10.7270/Q2PZ584G 12113838 Song, Y; Clizbe, L; Bhakta, C; Teng, W; Li, W; Wong, P; Huang, B; Sinha, U; Park, G; Reed, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115936&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9829120 104009764 51689 CHEMBL63088 ZINC26173538 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50209927 C\C(=C(/F)C(=O)Nc1ccc(cc1Cl)-c1ccccc1S(N)(=O)=O)c1ccc2ccnc(N)c2c1 InChI=1S/C25H20ClFN4O3S/c1-14(16-7-6-15-10-11-30-24(28)19(15)12-16)23(27)25(32)31-21-9-8-17(13-20(21)26)18-4-2-3-5-22(18)35(29,33)34/h2-13H,1H3,(H2,28,30)(H,31,32)(H2,29,33,34)/b23-14+ PZQXOASUPDYJBC-OEAKJJBVSA-N 50115933 (E)-3-(1-Amino-isoquinolin-7-yl)-2-fluoro-but-2-enoic acid (3-chloro-2'-sulfamoyl-biphenyl-4-yl)-amide::CHEMBL63041 Coagulation factor X Homo sapiens 1.1 ChEMBL 10.1016/s0960-894x(02)00304-9 10.7270/Q2PZ584G 12113838 Song, Y; Clizbe, L; Bhakta, C; Teng, W; Li, W; Wong, P; Huang, B; Sinha, U; Park, G; Reed, A; Scarborough, RM; Zhu, BY Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115933&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10029343 104009761 51689 CHEMBL63041 ZINC26174730 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50116444 CCOC(=O)C(Cc1ccc(cc1)C(N)=N)NC(=O)CNS(=O)(=O)c1ccc(cc1)C(N)=N InChI=1S/C21H26N6O5S/c1-2-32-21(29)17(11-13-3-5-14(6-4-13)19(22)23)27-18(28)12-26-33(30,31)16-9-7-15(8-10-16)20(24)25/h3-10,17,26H,2,11-12H2,1H3,(H3,22,23)(H3,24,25)(H,27,28) RHXBSZXVGSHOPS-UHFFFAOYSA-N 50067522 2-[2-(4-Carbamimidoyl-benzenesulfonylamino)-acetylamino]-3-(4-carbamimidoyl-phenyl)-propionic acid ethyl ester::CHEMBL135815 Coagulation factor X Homo sapiens 500 ChEMBL 10.1021/jm980227t 10.7270/Q27D2T86 9784099 Gabriel, B; Stubbs, MT; Bergner, A; Hauptmann, J; Bode, W; Sturzebecher, J; Moroder, L Institut für Biochemie http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067522&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10435038 103961961 CHEMBL135815 ZINC13781570 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50116458 NC(=N)c1ccc(cc1)S(=O)(=O)NCC(=O)NC(Cc1cccc(c1)C(N)=N)C(O)=O InChI=1S/C19H22N6O5S/c20-17(21)12-4-6-14(7-5-12)31(29,30)24-10-16(26)25-15(19(27)28)9-11-2-1-3-13(8-11)18(22)23/h1-8,15,24H,9-10H2,(H3,20,21)(H3,22,23)(H,25,26)(H,27,28) ALBBEOUDFZPYNJ-UHFFFAOYSA-N 50067523 2-[2-(4-Carbamimidoyl-benzenesulfonylamino)-acetylamino]-3-(3-carbamimidoyl-phenyl)-propionic acid::CHEMBL133027 Coagulation factor X Homo sapiens 18000 ChEMBL 10.1021/jm980227t 10.7270/Q27D2T86 9784099 Gabriel, B; Stubbs, MT; Bergner, A; Hauptmann, J; Bode, W; Sturzebecher, J; Moroder, L Institut für Biochemie http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067523&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10718240 103961962 CHEMBL133027 ZINC13781581 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50116463 CCOC(=O)C(Cc1cccc(c1)C(N)=N)NC(=O)CNS(=O)(=O)c1ccc(C)cc1 InChI=1S/C21H26N4O5S/c1-3-30-21(27)18(12-15-5-4-6-16(11-15)20(22)23)25-19(26)13-24-31(28,29)17-9-7-14(2)8-10-17/h4-11,18,24H,3,12-13H2,1-2H3,(H3,22,23)(H,25,26) DXPBRYSUDXIFKV-UHFFFAOYSA-N 50067525 3-(3-Carbamimidoyl-phenyl)-2-[2-(toluene-4-sulfonylamino)-acetylamino]-propionic acid ethyl ester::CHEMBL135041 Coagulation factor X Homo sapiens 1300 ChEMBL 10.1021/jm980227t 10.7270/Q27D2T86 9784099 Gabriel, B; Stubbs, MT; Bergner, A; Hauptmann, J; Bode, W; Sturzebecher, J; Moroder, L Institut für Biochemie http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067525&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 13755337 103961964 CHEMBL135041 ZINC13781569 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50116467 CCOC(=O)C(Cc1cccc(c1)C(N)=N)NC(=O)CNS(=O)(=O)c1ccc(cc1)C(N)=S InChI=1S/C21H25N5O5S2/c1-2-31-21(28)17(11-13-4-3-5-15(10-13)19(22)23)26-18(27)12-25-33(29,30)16-8-6-14(7-9-16)20(24)32/h3-10,17,25H,2,11-12H2,1H3,(H3,22,23)(H2,24,32)(H,26,27) YFHANJZAFYUYQQ-UHFFFAOYSA-N 50067528 3-(3-Carbamimidoyl-phenyl)-2-[2-(4-thiocarbamoyl-benzenesulfonylamino)-acetylamino]-propionic acid ethyl ester::CHEMBL336844 Coagulation factor X Homo sapiens 640 ChEMBL 10.1021/jm980227t 10.7270/Q27D2T86 9784099 Gabriel, B; Stubbs, MT; Bergner, A; Hauptmann, J; Bode, W; Sturzebecher, J; Moroder, L Institut für Biochemie http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067528&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10624948 103961967 CHEMBL336844 ZINC13781578 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50116471 CCOC(=O)C(Cc1ccc(cc1)C(N)=N)NC(=O)CNS(=O)(=O)c1ccc(cc1)C(N)=S InChI=1S/C21H25N5O5S2/c1-2-31-21(28)17(11-13-3-5-14(6-4-13)19(22)23)26-18(27)12-25-33(29,30)16-9-7-15(8-10-16)20(24)32/h3-10,17,25H,2,11-12H2,1H3,(H3,22,23)(H2,24,32)(H,26,27) XUBBHZIMNINHAR-UHFFFAOYSA-N 50067527 3-(4-Carbamimidoyl-phenyl)-2-[2-(4-thiocarbamoyl-benzenesulfonylamino)-acetylamino]-propionic acid ethyl ester::CHEMBL137311 Coagulation factor X Homo sapiens 7100 ChEMBL 10.1021/jm980227t 10.7270/Q27D2T86 9784099 Gabriel, B; Stubbs, MT; Bergner, A; Hauptmann, J; Bode, W; Sturzebecher, J; Moroder, L Institut für Biochemie http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067527&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10767421 103961966 CHEMBL137311 ZINC13781576 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50116490 COC(=O)C(Cc1cccc(c1)C(N)=N)NC(=O)CNS(=O)(=O)c1ccc(C)cc1 InChI=1S/C20H24N4O5S/c1-13-6-8-16(9-7-13)30(27,28)23-12-18(25)24-17(20(26)29-2)11-14-4-3-5-15(10-14)19(21)22/h3-10,17,23H,11-12H2,1-2H3,(H3,21,22)(H,24,25) YAEIKQDHLCFGAA-UHFFFAOYSA-N 50067532 3-(3-Carbamimidoyl-phenyl)-2-[2-(toluene-4-sulfonylamino)-acetylamino]-propionic acid methyl ester::CHEMBL423699 Coagulation factor X Homo sapiens 1800 ChEMBL 10.1021/jm980227t 10.7270/Q27D2T86 9784099 Gabriel, B; Stubbs, MT; Bergner, A; Hauptmann, J; Bode, W; Sturzebecher, J; Moroder, L Institut für Biochemie http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067532&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search ANH 3UNS,3UWI,1V2O,3V0X,3PLK,1V2R,1V2Q,1V2P,1V2W,1V2T,3PWC 13755335 103961971 CHEMBL423699 ZINC12501042 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50116494 CCOC(=O)C(Cc1cccc(c1)C(N)=N)NC(=O)CNS(=O)(=O)c1ccc(cc1)C(N)=N InChI=1S/C21H26N6O5S/c1-2-32-21(29)17(11-13-4-3-5-15(10-13)20(24)25)27-18(28)12-26-33(30,31)16-8-6-14(7-9-16)19(22)23/h3-10,17,26H,2,11-12H2,1H3,(H3,22,23)(H3,24,25)(H,27,28) PQBCMKLFEMRYGK-UHFFFAOYSA-N 50067529 2-[2-(4-Carbamimidoyl-benzenesulfonylamino)-acetylamino]-3-(3-carbamimidoyl-phenyl)-propionic acid ethyl ester::CHEMBL137780 Coagulation factor X Homo sapiens 820.0 ChEMBL 10.1021/jm980227t 10.7270/Q27D2T86 9784099 Gabriel, B; Stubbs, MT; Bergner, A; Hauptmann, J; Bode, W; Sturzebecher, J; Moroder, L Institut für Biochemie http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067529&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10648196 103961968 CHEMBL137780 ZINC13781571 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50116504 NC(=N)c1ccc(CC(NC(=O)CNS(=O)(=O)c2ccc(cc2)C(N)=N)C(O)=O)cc1 InChI=1S/C19H22N6O5S/c20-17(21)12-3-1-11(2-4-12)9-15(19(27)28)25-16(26)10-24-31(29,30)14-7-5-13(6-8-14)18(22)23/h1-8,15,24H,9-10H2,(H3,20,21)(H3,22,23)(H,25,26)(H,27,28) MREBMJAXNFLJHN-UHFFFAOYSA-N 50067526 2-[2-(4-Carbamimidoyl-benzenesulfonylamino)-acetylamino]-3-(4-carbamimidoyl-phenyl)-propionic acid::CHEMBL341933 Coagulation factor X Homo sapiens 3600 ChEMBL 10.1021/jm980227t 10.7270/Q27D2T86 9784099 Gabriel, B; Stubbs, MT; Bergner, A; Hauptmann, J; Bode, W; Sturzebecher, J; Moroder, L Institut für Biochemie http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067526&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10095093 103961965 CHEMBL341933 ZINC34208274 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50116513 CCOC(=O)C(Cc1ccc(cc1)C(N)=N)NC(=O)CNS(=O)(=O)c1ccc(cc1)C#N InChI=1S/C21H23N5O5S/c1-2-31-21(28)18(11-14-3-7-16(8-4-14)20(23)24)26-19(27)13-25-32(29,30)17-9-5-15(12-22)6-10-17/h3-10,18,25H,2,11,13H2,1H3,(H3,23,24)(H,26,27) CMUBVICFNAQVEP-UHFFFAOYSA-N 50067530 3-(4-Carbamimidoyl-phenyl)-2-[2-(4-cyano-benzenesulfonylamino)-acetylamino]-propionic acid ethyl ester::CHEMBL135198 Coagulation factor X Homo sapiens 8700.0 ChEMBL 10.1021/jm980227t 10.7270/Q27D2T86 9784099 Gabriel, B; Stubbs, MT; Bergner, A; Hauptmann, J; Bode, W; Sturzebecher, J; Moroder, L Institut für Biochemie http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067530&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10695159 103961969 CHEMBL135198 ZINC13781573 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50116517 CCOC(=O)C(Cc1cccc(c1)C(N)=N)NC(=O)CNS(=O)(=O)c1ccc(cc1)C#N InChI=1S/C21H23N5O5S/c1-2-31-21(28)18(11-15-4-3-5-16(10-15)20(23)24)26-19(27)13-25-32(29,30)17-8-6-14(12-22)7-9-17/h3-10,18,25H,2,11,13H2,1H3,(H3,23,24)(H,26,27) KKUDJWAGBDOUJA-UHFFFAOYSA-N 50067524 3-(3-Carbamimidoyl-phenyl)-2-[2-(4-cyano-benzenesulfonylamino)-acetylamino]-propionic acid ethyl ester::CHEMBL135998 Coagulation factor X Homo sapiens 5200 ChEMBL 10.1021/jm980227t 10.7270/Q27D2T86 9784099 Gabriel, B; Stubbs, MT; Bergner, A; Hauptmann, J; Bode, W; Sturzebecher, J; Moroder, L Institut für Biochemie http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067524&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11798089 103961963 CHEMBL135998 ZINC13781575 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50117700 O=C(CCCCNC(=O)OCc1ccccc1)OCN1C(=O)c2ccccc2S1(=O)=O InChI=1S/C21H22N2O7S/c24-19(12-6-7-13-22-21(26)29-14-16-8-2-1-3-9-16)30-15-23-20(25)17-10-4-5-11-18(17)31(23,27)28/h1-5,8-11H,6-7,12-15H2,(H,22,26) YPSXMLHFZYLLMR-UHFFFAOYSA-N 50068280 5-Benzyloxycarbonylamino-pentanoic acid 1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-ylmethyl ester::CHEMBL341885 Coagulation factor X Homo sapiens >33000 ChEMBL 10.1021/jm9804580 10.7270/Q21N8083 9822554 Combrink, KD; Gulgeze, HB; Meanwell, NA; Pearce, BC; Zulan, P; Bisacchi, GS; Roberts, DG; Stanley, P; Seiler, SM Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50068280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50068280&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10742017 103962550 CHEMBL341885 ZINC01546591 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50117717 O=C(CCNC(=O)OCc1ccccc1)OCN1C(=O)c2ccccc2S1(=O)=O InChI=1S/C19H18N2O7S/c22-17(10-11-20-19(24)27-12-14-6-2-1-3-7-14)28-13-21-18(23)15-8-4-5-9-16(15)29(21,25)26/h1-9H,10-13H2,(H,20,24) XGQXZQMZRZTGMF-UHFFFAOYSA-N 50068284 3-Benzyloxycarbonylamino-propionic acid 1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-ylmethyl ester::CHEMBL344560 Coagulation factor X Homo sapiens >33000 ChEMBL 10.1021/jm9804580 10.7270/Q21N8083 9822554 Combrink, KD; Gulgeze, HB; Meanwell, NA; Pearce, BC; Zulan, P; Bisacchi, GS; Roberts, DG; Stanley, P; Seiler, SM Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50068284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50068284&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10502109 103962554 CHEMBL344560 ZINC13782120 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50117855 O[C@@H]1[C@@H]2OC(=O)c3c1c(O)c(O)c(O)c3-c1c(O)c(O)c(O)cc1C(=O)O[C@H]2[C@@H]1OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c(O)cc2C(=O)OC[C@H]1O InChI=1S/C34H24O22/c35-8-1-5-12(21(42)18(8)39)13-6(2-9(36)19(40)22(13)43)32(50)54-28(11(38)4-53-31(5)49)30-29-26(47)17-16(34(52)55-29)15(24(45)27(48)25(17)46)14-7(33(51)56-30)3-10(37)20(41)23(14)44/h1-3,11,26,28-30,35-48H,4H2/t11-,26+,28-,29+,30+/m1/s1 CHBITXAMNKHJCR-VGYCLGPVSA-N 50269547 5-desgalloylstachyurin::CHEMBL488110 Coagulation factor X Homo sapiens 280 ChEMBL 10.1021/np9801458 10.7270/Q2NP2452 9834152 Dong, H; Chen, SX; Kini, RM; Xu, HX National University of Singapore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50269547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50269547&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10417809 104115211 CHEMBL488110 ZINC95615589 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50117856 O[C@H]1[C@@H]2OC(=O)c3c1c(O)c(O)c(O)c3-c1c(O)c(O)c(O)cc1C(=O)O[C@H]2[C@@H]1OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c(O)cc2C(=O)OC[C@H]1O InChI=1S/C34H24O22/c35-8-1-5-12(21(42)18(8)39)13-6(2-9(36)19(40)22(13)43)32(50)54-28(11(38)4-53-31(5)49)30-29-26(47)17-16(34(52)55-29)15(24(45)27(48)25(17)46)14-7(33(51)56-30)3-10(37)20(41)23(14)44/h1-3,11,26,28-30,35-48H,4H2/t11-,26-,28-,29+,30+/m1/s1 CHBITXAMNKHJCR-JNUHSSLSSA-N 50269546 CHEMBL509562::casuariin Coagulation factor X Homo sapiens 720 ChEMBL 10.1021/np9801458 10.7270/Q2NP2452 9834152 Dong, H; Chen, SX; Kini, RM; Xu, HX National University of Singapore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50269546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50269546&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 14035442 104115210 CHEMBL509562 ZINC95616064 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50117857 Oc1cc(cc(O)c1O)C(=O)OC1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)cc3C(=O)O[C@H]2[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1 InChI=1S/C41H30O26/c42-15-1-10(2-16(43)26(15)50)36(57)65-34-33-23(9-62-39(60)13-7-21(48)29(53)31(55)24(13)25-14(40(61)64-33)8-22(49)30(54)32(25)56)63-41(67-38(59)12-5-19(46)28(52)20(47)6-12)35(34)66-37(58)11-3-17(44)27(51)18(45)4-11/h1-8,23,33-35,41-56H,9H2/t23-,33-,34+,35-,41?/m1/s1 JCGHAEBIBSEQAD-WZASNERQSA-N 50269544 CHEMBL510512::tellimagrandin II Coagulation factor X Homo sapiens 210 ChEMBL 10.1021/np9801458 10.7270/Q2NP2452 9834152 Dong, H; Chen, SX; Kini, RM; Xu, HX National University of Singapore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50269544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50269544&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11766372 104115208 CHEMBL510512 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50117858 OC1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)cc3C(=O)O[C@H]2[C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)cc3C(=O)O[C@@H]12 InChI=1S/C34H24O22/c35-10-1-6-15(23(43)19(10)39)16-7(2-11(36)20(40)24(16)44)31(48)54-27-14(5-52-30(6)47)53-34(51)29-28(27)55-32(49)8-3-12(37)21(41)25(45)17(8)18-9(33(50)56-29)4-13(38)22(42)26(18)46/h1-4,14,27-29,34-46,51H,5H2/t14-,27-,28+,29-,34?/m1/s1 IYMHVUYNBVWXKH-ZITZVVOASA-N 50242262 CHEMBL506204::PEDUNCULAGIN Coagulation factor X Homo sapiens 560 ChEMBL 10.1021/np9801458 10.7270/Q2NP2452 9834152 Dong, H; Chen, SX; Kini, RM; Xu, HX National University of Singapore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242262&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 442688 104099005 CHEMBL506204 ZINC08234334 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50117859 Oc1cc(cc(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(O)c1 InChI=1S/C41H32O26/c42-17-1-12(2-18(43)28(17)52)36(57)62-11-27-33(64-37(58)13-3-19(44)29(53)20(45)4-13)34(65-38(59)14-5-21(46)30(54)22(47)6-14)35(66-39(60)15-7-23(48)31(55)24(49)8-15)41(63-27)67-40(61)16-9-25(50)32(56)26(51)10-16/h1-10,27,33-35,41-56H,11H2/t27-,33-,34+,35-,41+/m1/s1 QJYNZEYHSMRWBK-NIKIMHBISA-N 50241052 1,2,3,4,6-Pgg::1,2,3,4,6-pentakis-O-(3,4,5-trihydroxybenzoyl)-beta-D-glucopyranose::1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose::CHEMBL382408::acs.jmedchem.1c00409_ST.650::beta-D-glucopyranose pentakis(3,4,5-trihydroxybenzoate) Coagulation factor X Homo sapiens 170 ChEMBL 10.1021/np9801458 10.7270/Q2NP2452 9834152 Dong, H; Chen, SX; Kini, RM; Xu, HX National University of Singapore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241052&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 65238 104098581 18082 CHEMBL382408 C04576 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50117860 O[C@@H]1[C@@H]2OC(=O)c3c1c(O)c(O)c(O)c3-c1c(O)c(O)c(O)cc1C(=O)O[C@H]2[C@@H]1OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c(O)cc2C(=O)OC[C@H]1O InChI=1S/C34H24O22/c35-8-1-5-12(21(42)18(8)39)13-6(2-9(36)19(40)22(13)43)32(50)54-28(11(38)4-53-31(5)49)30-29-26(47)17-16(34(52)55-29)15(24(45)27(48)25(17)46)14-7(33(51)56-30)3-10(37)20(41)23(14)44/h1-3,11,26,28-30,35-48H,4H2/t11-,26+,28-,29+,30+/m1/s1 CHBITXAMNKHJCR-VGYCLGPVSA-N 50269547 5-desgalloylstachyurin::CHEMBL488110 Coagulation factor X Homo sapiens 690 ChEMBL 10.1021/np9801458 10.7270/Q2NP2452 9834152 Dong, H; Chen, SX; Kini, RM; Xu, HX National University of Singapore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50269547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50269547&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10417809 104115211 CHEMBL488110 ZINC95615589 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50117861 O[C@H]1[C@@H]2OC(=O)c3c1c(O)c(O)c(O)c3-c1c(O)c(O)c(O)cc1C(=O)O[C@H]2[C@@H]1OC(=O)c2cc(O)c(O)c(O)c2-c2c(O)c(O)c(O)cc2C(=O)OC[C@H]1O InChI=1S/C34H24O22/c35-8-1-5-12(21(42)18(8)39)13-6(2-9(36)19(40)22(13)43)32(50)54-28(11(38)4-53-31(5)49)30-29-26(47)17-16(34(52)55-29)15(24(45)27(48)25(17)46)14-7(33(51)56-30)3-10(37)20(41)23(14)44/h1-3,11,26,28-30,35-48H,4H2/t11-,26-,28-,29+,30+/m1/s1 CHBITXAMNKHJCR-JNUHSSLSSA-N 50269546 CHEMBL509562::casuariin Coagulation factor X Homo sapiens 450 ChEMBL 10.1021/np9801458 10.7270/Q2NP2452 9834152 Dong, H; Chen, SX; Kini, RM; Xu, HX National University of Singapore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50269546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50269546&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 14035442 104115210 CHEMBL509562 ZINC95616064 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50117862 Oc1cc(cc(O)c1O)C(=O)OC1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)cc3C(=O)O[C@H]2[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1 InChI=1S/C41H30O26/c42-15-1-10(2-16(43)26(15)50)36(57)65-34-33-23(9-62-39(60)13-7-21(48)29(53)31(55)24(13)25-14(40(61)64-33)8-22(49)30(54)32(25)56)63-41(67-38(59)12-5-19(46)28(52)20(47)6-12)35(34)66-37(58)11-3-17(44)27(51)18(45)4-11/h1-8,23,33-35,41-56H,9H2/t23-,33-,34+,35-,41?/m1/s1 JCGHAEBIBSEQAD-WZASNERQSA-N 50269544 CHEMBL510512::tellimagrandin II Coagulation factor X Homo sapiens 440 ChEMBL 10.1021/np9801458 10.7270/Q2NP2452 9834152 Dong, H; Chen, SX; Kini, RM; Xu, HX National University of Singapore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50269544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50269544&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11766372 104115208 CHEMBL510512 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50117863 OC1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)cc3C(=O)O[C@H]2[C@@H]2OC(=O)c3cc(O)c(O)c(O)c3-c3c(O)c(O)c(O)cc3C(=O)O[C@@H]12 InChI=1S/C34H24O22/c35-10-1-6-15(23(43)19(10)39)16-7(2-11(36)20(40)24(16)44)31(48)54-27-14(5-52-30(6)47)53-34(51)29-28(27)55-32(49)8-3-12(37)21(41)25(45)17(8)18-9(33(50)56-29)4-13(38)22(42)26(18)46/h1-4,14,27-29,34-46,51H,5H2/t14-,27-,28+,29-,34?/m1/s1 IYMHVUYNBVWXKH-ZITZVVOASA-N 50242262 CHEMBL506204::PEDUNCULAGIN Coagulation factor X Homo sapiens 990 ChEMBL 10.1021/np9801458 10.7270/Q2NP2452 9834152 Dong, H; Chen, SX; Kini, RM; Xu, HX National University of Singapore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242262&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 442688 104099005 CHEMBL506204 ZINC08234334 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50117864 Oc1cc(cc(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(O)c1 InChI=1S/C41H32O26/c42-17-1-12(2-18(43)28(17)52)36(57)62-11-27-33(64-37(58)13-3-19(44)29(53)20(45)4-13)34(65-38(59)14-5-21(46)30(54)22(47)6-14)35(66-39(60)15-7-23(48)31(55)24(49)8-15)41(63-27)67-40(61)16-9-25(50)32(56)26(51)10-16/h1-10,27,33-35,41-56H,11H2/t27-,33-,34+,35-,41+/m1/s1 QJYNZEYHSMRWBK-NIKIMHBISA-N 50241052 1,2,3,4,6-Pgg::1,2,3,4,6-pentakis-O-(3,4,5-trihydroxybenzoyl)-beta-D-glucopyranose::1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose::CHEMBL382408::acs.jmedchem.1c00409_ST.650::beta-D-glucopyranose pentakis(3,4,5-trihydroxybenzoate) Coagulation factor X Homo sapiens 570 ChEMBL 10.1021/np9801458 10.7270/Q2NP2452 9834152 Dong, H; Chen, SX; Kini, RM; Xu, HX National University of Singapore http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241052&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 65238 104098581 18082 CHEMBL382408 C04576 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114744 NC(=N)c1cccc(\C=C2/CCCC\C(=C/c3cccc(c3)C(N)=N)C2=O)c1 InChI=1S/C23H24N4O/c24-22(25)19-9-3-5-15(13-19)11-17-7-1-2-8-18(21(17)28)12-16-6-4-10-20(14-16)23(26)27/h3-6,9-14H,1-2,7-8H2,(H3,24,25)(H3,26,27)/b17-11+,18-12+ PHAIUFIPJBFOPT-JYFOCSDGSA-N 50066612 (E,E)-2,7-Bis(4-amidinobenzylidine)cycloheptan-1-one::2,7-di[1-[3-amino(imino)methylphenyl]-(E)-methylidene]-1-cycloheptanone::CHEMBL326552 Coagulation factor X Homo sapiens 1400 ChEMBL 10.1021/jm980281+ 10.7270/Q2QJ7GFX 9733479 Shaw, KJ; Guilford, WJ; Dallas, JL; Koovakkaat, SK; McCarrick, MA; Liang, A; Light, DR; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066612&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10833102 103961232 CHEMBL326552 ZINC13781055 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114745 NC(=N)c1cccc(\C=C2\CCCC\C(=C/c3cccc(c3)C(N)=N)C2=O)c1 InChI=1S/C23H24N4O/c24-22(25)19-9-3-5-15(13-19)11-17-7-1-2-8-18(21(17)28)12-16-6-4-10-20(14-16)23(26)27/h3-6,9-14H,1-2,7-8H2,(H3,24,25)(H3,26,27)/b17-11-,18-12+ PHAIUFIPJBFOPT-MJZABRMRSA-N 50066613 (E,Z)-2,7-Bis(4-amidinobenzylidine)cycloheptan-1-one::2-[1-[3-amino(imino)methylphenyl]-(E)-methylidene]-7-[1-[3-amino(imino)methylphenyl]-(Z)-methylidene]-1-cycloheptanone::CHEMBL325022 Coagulation factor X Homo sapiens 140 ChEMBL 10.1021/jm980281+ 10.7270/Q2QJ7GFX 9733479 Shaw, KJ; Guilford, WJ; Dallas, JL; Koovakkaat, SK; McCarrick, MA; Liang, A; Light, DR; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066613&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10547293 103961233 CHEMBL325022 ZINC13781056 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114747 NC(=N)c1ccc(\C=C2\CCCC\C(=C\c3ccc(cc3)C(N)=N)C2=O)cc1 InChI=1S/C23H24N4O/c24-22(25)17-9-5-15(6-10-17)13-19-3-1-2-4-20(21(19)28)14-16-7-11-18(12-8-16)23(26)27/h5-14H,1-4H2,(H3,24,25)(H3,26,27)/b19-13-,20-14- BGRKMKHJBDYTGS-AXPXABNXSA-N 17277 (Z,Z)BABCH::4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl)methylidene]-2-oxocycloheptylidene]methyl}benzene-1-carboximidamide::CHEMBL55035 Coagulation factor X Homo sapiens 0.66 ChEMBL 10.1021/jm980281+ 10.7270/Q2QJ7GFX 9733479 Shaw, KJ; Guilford, WJ; Dallas, JL; Koovakkaat, SK; McCarrick, MA; Liang, A; Light, DR; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17277&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1A5H,1V2N 10361934 46517455 CHEMBL55035 ZINC01545718 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114750 NC(=N)c1ccc(\C=C2/CCCC\C(=C/c3ccc(cc3)C(N)=N)C2=O)cc1 InChI=1S/C23H24N4O/c24-22(25)17-9-5-15(6-10-17)13-19-3-1-2-4-20(21(19)28)14-16-7-11-18(12-8-16)23(26)27/h5-14H,1-4H2,(H3,24,25)(H3,26,27)/b19-13+,20-14+ BGRKMKHJBDYTGS-IWGRKNQJSA-N 50066614 (E,E)-2,7-Bis(4-amidinobenzylidine)cycloheptan-1-one::2,7-di[1-[4-amino(imino)methylphenyl]-(E)-methylidene]-1-cycloheptanone::CHEMBL48233 Coagulation factor X Homo sapiens 17000 ChEMBL 10.1021/jm980281+ 10.7270/Q2QJ7GFX 9733479 Shaw, KJ; Guilford, WJ; Dallas, JL; Koovakkaat, SK; McCarrick, MA; Liang, A; Light, DR; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066614&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 639391 103961234 CHEMBL48233 ZINC38141175 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114753 NC(=N)c1ccc(\C=C2\CCCC\C(=C/c3ccc(cc3)C(N)=N)C2=O)cc1 InChI=1S/C23H24N4O/c24-22(25)17-9-5-15(6-10-17)13-19-3-1-2-4-20(21(19)28)14-16-7-11-18(12-8-16)23(26)27/h5-14H,1-4H2,(H3,24,25)(H3,26,27)/b19-13-,20-14+ BGRKMKHJBDYTGS-LRVMPXQBSA-N 50066615 (E,Z)-2,7-Bis(4-amidinobenzylidine)cycloheptan-1-one::2-[1-[4-amino(imino)methylphenyl]-(E)-methylidene]-7-[1-[4-amino(imino)methylphenyl]-(Z)-methylidene]-1-cycloheptanone::CHEMBL94336 Coagulation factor X Homo sapiens 200 ChEMBL 10.1021/jm980281+ 10.7270/Q2QJ7GFX 9733479 Shaw, KJ; Guilford, WJ; Dallas, JL; Koovakkaat, SK; McCarrick, MA; Liang, A; Light, DR; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066615&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10523322 103961235 CHEMBL94336 ZINC01545717 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114754 NC(=N)c1cccc(\C=C2\CCCC\C(=C\c3cccc(c3)C(N)=N)C2=O)c1 InChI=1S/C23H24N4O/c24-22(25)19-9-3-5-15(13-19)11-17-7-1-2-8-18(21(17)28)12-16-6-4-10-20(14-16)23(26)27/h3-6,9-14H,1-2,7-8H2,(H3,24,25)(H3,26,27)/b17-11-,18-12- PHAIUFIPJBFOPT-WHYMJUELSA-N 50066616 (Z,Z)-2,7-Bis(4-amidinobenzylidine)cycloheptan-1-one::2,7-di[1-[3-amino(imino)methylphenyl]-(Z)-methylidene]-1-cycloheptanone::CHEMBL331437 Coagulation factor X Homo sapiens 5.6 ChEMBL 10.1021/jm980281+ 10.7270/Q2QJ7GFX 9733479 Shaw, KJ; Guilford, WJ; Dallas, JL; Koovakkaat, SK; McCarrick, MA; Liang, A; Light, DR; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066616&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10785523 103961236 CHEMBL331437 ZINC13781057 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114766 CN(C)C(=O)c1cccc(Oc2cc(cc(Oc3cc(ccc3O)C(N)=N)n2)C(O)=O)c1 InChI=1S/C22H20N4O6/c1-26(2)21(28)13-4-3-5-15(8-13)31-18-10-14(22(29)30)11-19(25-18)32-17-9-12(20(23)24)6-7-16(17)27/h3-11,27H,1-2H3,(H3,23,24)(H,29,30) RPCHETUIUZUTRF-UHFFFAOYSA-N 50066622 2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-(3-dimethylcarbamoyl-phenoxy)-isonicotinic acid::CHEMBL79303 Coagulation factor X Homo sapiens 3.9 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066622&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10812814 103961242 CHEMBL79303 ZINC13474065 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114768 Cc1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2cccc(c2)C(N)=O)c1F InChI=1S/C20H16F2N4O3/c1-10-15(21)19(28-13-6-2-4-11(8-13)17(23)24)26-20(16(10)22)29-14-7-3-5-12(9-14)18(25)27/h2-9H,1H3,(H3,23,24)(H2,25,27) SQMDPBNOJWCMCP-UHFFFAOYSA-N 50066624 3-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-benzamide::CHEMBL81579 Coagulation factor X Homo sapiens 280 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066624&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10715861 103961244 CHEMBL81579 ZINC13473984 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114771 NC(=N)c1cccc(Oc2cccc(Oc3cccc(c3)C(N)=N)n2)c1 InChI=1S/C19H17N5O2/c20-18(21)12-4-1-6-14(10-12)25-16-8-3-9-17(24-16)26-15-7-2-5-13(11-15)19(22)23/h1-11H,(H3,20,21)(H3,22,23) WNTHPCMKWFKFIU-UHFFFAOYSA-N 50066626 3-{6-[3-amino(imino)methylphenoxy]-2-pyridyloxy}phenyl-iminomethanamine::CHEMBL50127 Coagulation factor X Homo sapiens 53 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066626&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10831506 103961246 CHEMBL50127 ZINC13781059 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114772 NC(=N)c1cccc(Oc2cc(cc(Oc3cccc(c3)C(N)=N)n2)C(O)=O)c1 InChI=1S/C20H17N5O4/c21-18(22)11-3-1-5-14(7-11)28-16-9-13(20(26)27)10-17(25-16)29-15-6-2-4-12(8-15)19(23)24/h1-10H,(H3,21,22)(H3,23,24)(H,26,27) NKMYAABWJWHHLH-UHFFFAOYSA-N 50066620 2,6-Bis-(3-carbamimidoyl-phenoxy)-isonicotinic acid::CHEMBL48604 Coagulation factor X Homo sapiens 59 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066620&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10715476 103961240 CHEMBL48604 ZINC13474062 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114775 NC(=N)c1ccc(O)c(Oc2cc(cc(Oc3cccc(c3)-n3ccnc3)n2)C(O)=O)c1 InChI=1S/C22H17N5O5/c23-21(24)13-4-5-17(28)18(8-13)32-20-10-14(22(29)30)9-19(26-20)31-16-3-1-2-15(11-16)27-7-6-25-12-27/h1-12,28H,(H3,23,24)(H,29,30) KUPOJJBTUCGDJK-UHFFFAOYSA-N 50066617 2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-(3-imidazol-1-yl-phenoxy)-isonicotinic acid::CHEMBL310373 Coagulation factor X Homo sapiens 26 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066617&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10717547 103961237 CHEMBL310373 ZINC13474067 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114776 NC(=N)c1cccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(Cl)cc2Cl)c1 InChI=1S/C19H15Cl2N5O2/c20-14-9-15(21)19(28-13-6-2-4-11(8-13)17(24)25)26-18(14)27-12-5-1-3-10(7-12)16(22)23/h1-9H,(H3,22,23)(H3,24,25) VBRBATJVFAKEBY-UHFFFAOYSA-N 50066629 3-{6-[3-amino(imino)methylphenoxy]-3,5-dichloro-2-pyridyloxy}phenyl-iminomethanamine::CHEMBL48864 Coagulation factor X Homo sapiens 130 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066629&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10525943 103961249 CHEMBL48864 ZINC13781061 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114782 CN(C)C(=O)c1cccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(C)c2F)c1 InChI=1S/C22H20F2N4O3/c1-12-17(23)20(30-15-8-4-6-13(10-15)19(25)26)27-21(18(12)24)31-16-9-5-7-14(11-16)22(29)28(2)3/h4-11H,1-3H3,(H3,25,26) WBQTWIMCPJDTPA-UHFFFAOYSA-N 50066633 3-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-N,N-dimethyl-benzamide::CHEMBL70730 Coagulation factor X Homo sapiens 80 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066633&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11743193 103961253 CHEMBL70730 ZINC13473988 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114784 Cc1c(F)c(Oc2ccccc2)nc(Oc2cccc(c2)C(N)=N)c1F InChI=1S/C19H15F2N3O2/c1-11-15(20)18(25-13-7-3-2-4-8-13)24-19(16(11)21)26-14-9-5-6-12(10-14)17(22)23/h2-10H,1H3,(H3,22,23) SZLVLFLVQNHHRF-UHFFFAOYSA-N 50066621 3-(3,5-Difluoro-4-methyl-6-phenoxy-pyridin-2-yloxy)-benzamidine::CHEMBL81852 Coagulation factor X Homo sapiens >5000 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066621&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10832026 103961241 CHEMBL81852 ZINC13473983 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114788 CN1CCN=C1c1cccc(Oc2cc(cc(Oc3cc(ccc3O)C(N)=N)n2)C(O)=O)c1 InChI=1S/C23H21N5O5/c1-28-8-7-26-22(28)14-3-2-4-16(9-14)32-19-11-15(23(30)31)12-20(27-19)33-18-10-13(21(24)25)5-6-17(18)29/h2-6,9-12,29H,7-8H2,1H3,(H3,24,25)(H,30,31) RFXKVRQVMAZJNN-UHFFFAOYSA-N 50066637 2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)-phenoxy]-isonicotinic acid::CHEMBL84065 Coagulation factor X Homo sapiens 2.4 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066637&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10388915 103961257 CHEMBL84065 ZINC01911692 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114789 Cn1ccnc1-c1cccc(Oc2cc(cc(Oc3cc(ccc3O)C(N)=N)n2)C(O)=O)c1 InChI=1S/C23H19N5O5/c1-28-8-7-26-22(28)14-3-2-4-16(9-14)32-19-11-15(23(30)31)12-20(27-19)33-18-10-13(21(24)25)5-6-17(18)29/h2-12,29H,1H3,(H3,24,25)(H,30,31) ANYDGTKZBSTRJJ-UHFFFAOYSA-N 50066636 2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-[3-(1-methyl-1H-imidazol-2-yl)-phenoxy]-isonicotinic acid::CHEMBL309541 Coagulation factor X Homo sapiens 9 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066636&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10765739 103961256 CHEMBL309541 ZINC38167558 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114790 NC(=N)c1ccc(Oc2cccc(Oc3ccc(cc3)C(N)=N)n2)cc1 InChI=1S/C19H17N5O2/c20-18(21)12-4-8-14(9-5-12)25-16-2-1-3-17(24-16)26-15-10-6-13(7-11-15)19(22)23/h1-11H,(H3,20,21)(H3,22,23) VATCDKFGSBVBMX-UHFFFAOYSA-N 50066618 4-{6-[4-amino(imino)methylphenoxy]-2-pyridyloxy}phenyl-iminomethanamine::CHEMBL298415 Coagulation factor X Homo sapiens 400 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066618&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9997816 103961238 CHEMBL298415 ZINC13781058 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114791 CN(C)C(=O)c1cccc(Oc2nc(Oc3cc(ccc3N)C(N)=N)c(F)c(C)c2F)c1 InChI=1S/C22H21F2N5O3/c1-11-17(23)20(31-14-6-4-5-13(9-14)22(30)29(2)3)28-21(18(11)24)32-16-10-12(19(26)27)7-8-15(16)25/h4-10H,25H2,1-3H3,(H3,26,27) JENACQRKAHXTRB-UHFFFAOYSA-N 50066627 3-[6-(2-Amino-5-carbamimidoyl-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-N,N-dimethyl-benzamide::CHEMBL79986 Coagulation factor X Homo sapiens 14 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066627&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10813043 103961247 CHEMBL79986 ZINC03815599 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114793 COc1ccc(cc1Oc1nc(Oc2cccc(c2)C(=O)N(C)C)c(F)c(C)c1F)C(N)=N InChI=1S/C23H22F2N4O4/c1-12-18(24)21(32-15-7-5-6-14(10-15)23(30)29(2)3)28-22(19(12)25)33-17-11-13(20(26)27)8-9-16(17)31-4/h5-11H,1-4H3,(H3,26,27) YFRQQLMNZPPWOI-UHFFFAOYSA-N 50066630 3-[6-(5-Carbamimidoyl-2-methoxy-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-N,N-dimethyl-benzamide::CHEMBL311608 Coagulation factor X Homo sapiens 740 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066630&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10623670 103961250 CHEMBL311608 ZINC13474055 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114803 NC(=N)c1ccc(Oc2nc(Oc3ccc(cc3)C(N)=N)c(Cl)cc2Cl)cc1 InChI=1S/C19H15Cl2N5O2/c20-14-9-15(21)19(28-13-7-3-11(4-8-13)17(24)25)26-18(14)27-12-5-1-10(2-6-12)16(22)23/h1-9H,(H3,22,23)(H3,24,25) HRUCQVIIUGSDPQ-UHFFFAOYSA-N 50066631 4-[3,5-Dichloro-6-(4-diaminomethyl-phenoxy)-pyridin-2-yloxy]-benzamidine::4-{6-[4-amino(imino)methylphenoxy]-3,5-dichloro-2-pyridyloxy}phenyl-iminomethanamine::CHEMBL49786 Coagulation factor X Homo sapiens 620 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066631&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10573919 103961251 CHEMBL49786 ZINC13781060 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114810 NC(=N)c1ccc(\C=C2\CCCC\C(=C\c3ccc(cc3)C(N)=N)C2=O)cc1 InChI=1S/C23H24N4O/c24-22(25)17-9-5-15(6-10-17)13-19-3-1-2-4-20(21(19)28)14-16-7-11-18(12-8-16)23(26)27/h5-14H,1-4H2,(H3,24,25)(H3,26,27)/b19-13-,20-14- BGRKMKHJBDYTGS-AXPXABNXSA-N 17277 (Z,Z)BABCH::4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl)methylidene]-2-oxocycloheptylidene]methyl}benzene-1-carboximidamide::CHEMBL55035 Coagulation factor X Homo sapiens 0.66 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17277&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1A5H,1V2N 10361934 46517455 CHEMBL55035 ZINC01545718 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114813 NC(=N)c1ccc(O)c(Oc2cc(cc(Oc3cccc(c3)C3=NCCN3)n2)C(O)=O)c1 InChI=1S/C22H19N5O5/c23-20(24)12-4-5-16(28)17(9-12)32-19-11-14(22(29)30)10-18(27-19)31-15-3-1-2-13(8-15)21-25-6-7-26-21/h1-5,8-11,28H,6-7H2,(H3,23,24)(H,25,26)(H,29,30) KDDSLUYCOZXRQI-UHFFFAOYSA-N 17279 2-(5-carbamimidoyl-2-hydroxyphenoxy)-6-[3-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridine-4-carboxylic acid::CHEMBL315014::Pyridine template, IV::ZK-806688 Coagulation factor X Homo sapiens 85 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17279&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1QBN 10388137 46517457 CHEMBL315014 ZINC12355224 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114818 NC(=N)c1ccc(Oc2cccc(Oc3cccc(c3)C(N)=N)n2)cc1 InChI=1S/C19H17N5O2/c20-18(21)12-7-9-14(10-8-12)25-16-5-2-6-17(24-16)26-15-4-1-3-13(11-15)19(22)23/h1-11H,(H3,20,21)(H3,22,23) QEMTWMGKVFLKPT-UHFFFAOYSA-N 50066642 4-{6-[3-amino(imino)methylphenoxy]-2-pyridyloxy}phenyl-iminomethanamine::CHEMBL330802 Coagulation factor X Homo sapiens 130 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066642&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10665326 103961262 CHEMBL330802 ZINC13781062 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114819 CN1CCN=C1c1cccc(Oc2nc(Oc3cc(ccc3O)C(N)=N)c(F)c(OC3CCN(CC(O)=O)CC3)c2F)c1 InChI=1S/C29H30F2N6O6/c1-36-12-9-34-27(36)17-3-2-4-19(13-17)42-28-23(30)25(41-18-7-10-37(11-8-18)15-22(39)40)24(31)29(35-28)43-21-14-16(26(32)33)5-6-20(21)38/h2-6,13-14,18,38H,7-12,15H2,1H3,(H3,32,33)(H,39,40) ZKPMPXGSEXIYPL-UHFFFAOYSA-N 50066635 (4-{2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3,5-difluoro-6-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)-phenoxy]-pyridin-4-yloxy}-piperidin-1-yl)-acetic acid::CHEMBL332322 Coagulation factor X Homo sapiens 0.24 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066635&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10579402 103961255 CHEMBL332322 ZINC01892573 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114820 CN1CCN=C1c1cccc(Oc2nc(Oc3cc(ccc3O)C(N)=N)c(F)c(O[C@H]3CN[C@@H](C3)C(O)=O)c2F)c1 InChI=1S/C27H26F2N6O6/c1-35-8-7-32-24(35)14-3-2-4-15(9-14)40-25-20(28)22(39-16-11-17(27(37)38)33-12-16)21(29)26(34-25)41-19-10-13(23(30)31)5-6-18(19)36/h2-6,9-10,16-17,33,36H,7-8,11-12H2,1H3,(H3,30,31)(H,37,38)/t16-,17+/m1/s1 VNQPTQBZRMCGSE-SJORKVTESA-N 50066641 (2S,4R)-4-{2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3,5-difluoro-6-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)-phenoxy]-pyridin-4-yloxy}-pyrrolidine-2-carboxylic acid::CHEMBL332189 Coagulation factor X Homo sapiens 0.33 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066641&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11801138 103961261 CHEMBL332189 ZINC27102458 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114821 CNC(=O)c1cccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(C)c2F)c1 InChI=1S/C21H18F2N4O3/c1-11-16(22)20(29-14-7-3-5-12(9-14)18(24)25)27-21(17(11)23)30-15-8-4-6-13(10-15)19(28)26-2/h3-10H,1-2H3,(H3,24,25)(H,26,28) MVFBCJUJUYGZKY-UHFFFAOYSA-N 50066643 3-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-N-methyl-benzamide::CHEMBL79735 Coagulation factor X Homo sapiens 1300 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066643&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10811600 103961263 CHEMBL79735 ZINC13473987 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114823 CN(C)c1cccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(C)c2F)c1 InChI=1S/C21H20F2N4O2/c1-12-17(22)20(28-15-8-4-6-13(10-15)19(24)25)26-21(18(12)23)29-16-9-5-7-14(11-16)27(2)3/h4-11H,1-3H3,(H3,24,25) WKTQHMDHPOBDIS-UHFFFAOYSA-N 50066632 3-[6-(3-Dimethylamino-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-benzamidine::CHEMBL83675 Coagulation factor X Homo sapiens 160 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066632&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11795137 103961252 CHEMBL83675 ZINC13474013 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114831 CCOC(=O)[C@@H]1C[C@H](CN1)Oc1c(F)c(Oc2cccc(c2)C(=O)N(C)C)nc(Oc2cc(ccc2O)C(N)=N)c1F InChI=1S/C28H29F2N5O7/c1-4-39-28(38)18-12-17(13-33-18)40-23-21(29)25(41-16-7-5-6-15(10-16)27(37)35(2)3)34-26(22(23)30)42-20-11-14(24(31)32)8-9-19(20)36/h5-11,17-18,33,36H,4,12-13H2,1-3H3,(H3,31,32)/t17-,18+/m1/s1 GHFFMACRDHXSJW-MSOLQXFVSA-N 50066628 (2S,4R)-4-[2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-(3-dimethylcarbamoyl-phenoxy)-3,5-difluoro-pyridin-4-yloxy]-pyrrolidine-2-carboxylic acid ethyl ester::CHEMBL332388 Coagulation factor X Homo sapiens 0.71 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066628&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10650967 103961248 CHEMBL332388 ZINC27103989 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114832 CN(C)C(=O)c1cccc(Oc2nc(Oc3cc(ccc3O)C(N)=N)c(F)c(C)c2F)c1 InChI=1S/C22H20F2N4O4/c1-11-17(23)20(31-14-6-4-5-13(9-14)22(30)28(2)3)27-21(18(11)24)32-16-10-12(19(25)26)7-8-15(16)29/h4-10,29H,1-3H3,(H3,25,26) PLQZURZWZWZNAM-UHFFFAOYSA-N 50066638 3-[6-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-N,N-dimethyl-benzamide::CHEMBL419651 Coagulation factor X Homo sapiens 1.2 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066638&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11744056 103961258 CHEMBL419651 ZINC13474054 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114833 Cc1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2cccc(c2)C(N)=N)c1F InChI=1S/C20H17F2N5O2/c1-10-15(21)19(28-13-6-2-4-11(8-13)17(23)24)27-20(16(10)22)29-14-7-3-5-12(9-14)18(25)26/h2-9H,1H3,(H3,23,24)(H3,25,26) ZXIHYCYAQUQHSG-UHFFFAOYSA-N 17278 3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-methylpyridin-2-yl]oxy}benzene-1-carboximidamide::CHEMBL49636::Pyridine template, III::ZK-805623 Coagulation factor X Homo sapiens 13 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17278&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1QB6 448061 46517456 CHEMBL49636 ZINC00585999 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114835 NC(=N)c1cccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)cc2F)c1 InChI=1S/C19H15F2N5O2/c20-14-9-15(21)19(28-13-6-2-4-11(8-13)17(24)25)26-18(14)27-12-5-1-3-10(7-12)16(22)23/h1-9H,(H3,22,23)(H3,24,25) YSBKPPPTSBMIHQ-UHFFFAOYSA-N 50066640 3-{6-[3-amino(imino)methylphenoxy]-3,5-difluoro-2-pyridyloxy}phenyl-iminomethanamine::CHEMBL424036 Coagulation factor X Homo sapiens 24 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066640&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10691360 103961260 CHEMBL424036 ZINC13781063 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114837 CN(C)C(=O)c1cccc(Oc2nc(Oc3cc(ccc3O)C(N)=N)c(F)c(N(C)CC(O)=O)c2F)c1 InChI=1S/C24H23F2N5O6/c1-30(2)24(35)13-5-4-6-14(9-13)36-22-18(25)20(31(3)11-17(33)34)19(26)23(29-22)37-16-10-12(21(27)28)7-8-15(16)32/h4-10,32H,11H2,1-3H3,(H3,27,28)(H,33,34) SJXRMUMLUCMWJJ-UHFFFAOYSA-N 50066623 CHEMBL72318::{[2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-(3-dimethylcarbamoyl-phenoxy)-3,5-difluoro-pyridin-4-yl]-methyl-amino}-acetic acid Coagulation factor X Homo sapiens 0.41 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066623&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10649512 103961243 CHEMBL72318 ZINC13781064 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114838 CN(CC(O)=O)c1c(F)c(Oc2cccc(c2)C2=NCCN2C)nc(Oc2cc(ccc2O)C(N)=N)c1F InChI=1S/C25H24F2N6O5/c1-32-9-8-30-23(32)14-4-3-5-15(10-14)37-24-19(26)21(33(2)12-18(35)36)20(27)25(31-24)38-17-11-13(22(28)29)6-7-16(17)34/h3-7,10-11,34H,8-9,12H2,1-2H3,(H3,28,29)(H,35,36) NPNSVNGQJGRSNR-UHFFFAOYSA-N 17284 2-{[2-(5-carbamimidoyl-2-hydroxyphenoxy)-3,5-difluoro-6-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridin-4-yl](methyl)amino}acetic acid::CHEMBL73193::CI-1031::ZK-807834 Coagulation factor X Homo sapiens 0.11 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17284&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search Z34 1FJS 5353802 46517462 CHEMBL73193 ZINC01902827 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114842 CCOC(=O)CN1CCC(CC1)Oc1c(F)c(Oc2cccc(c2)C2=NCCN2C)nc(Oc2cc(ccc2O)C(N)=N)c1F InChI=1S/C31H34F2N6O6/c1-3-42-24(41)17-39-12-9-20(10-13-39)43-27-25(32)30(44-21-6-4-5-19(15-21)29-36-11-14-38(29)2)37-31(26(27)33)45-23-16-18(28(34)35)7-8-22(23)40/h4-8,15-16,20,40H,3,9-14,17H2,1-2H3,(H3,34,35) VITCTALXBLQAIZ-UHFFFAOYSA-N 50066634 (4-{2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3,5-difluoro-6-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)-phenoxy]-pyridin-4-yloxy}-piperidin-1-yl)-acetic acid ethyl ester::CHEMBL331690 Coagulation factor X Homo sapiens 0.31 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066634&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10722591 103961254 CHEMBL331690 ZINC27182236 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114844 CN(C)C(=O)c1cccc(Oc2nc(Oc3cc(ccc3O)C(N)=N)c(F)c(OC3CCN(CC(O)=O)CC3)c2F)c1 InChI=1S/C28H29F2N5O7/c1-34(2)28(39)16-4-3-5-18(12-16)41-26-22(29)24(40-17-8-10-35(11-9-17)14-21(37)38)23(30)27(33-26)42-20-13-15(25(31)32)6-7-19(20)36/h3-7,12-13,17,36H,8-11,14H2,1-2H3,(H3,31,32)(H,37,38) CYUIADSAPKIADJ-UHFFFAOYSA-N 50066625 CHEMBL120438::{4-[2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-(3-dimethylcarbamoyl-phenoxy)-3,5-difluoro-pyridin-4-yloxy]-piperidin-1-yl}-acetic acid Coagulation factor X Homo sapiens 0.65 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066625&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10603410 103961245 CHEMBL120438 ZINC27110078 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114846 CCOC(=O)[C@@H]1C[C@H](CN1)Oc1c(F)c(Oc2cccc(c2)C2=NCCN2C)nc(Oc2cc(ccc2O)C(N)=N)c1F InChI=1S/C29H30F2N6O6/c1-3-40-29(39)19-13-18(14-35-19)41-24-22(30)27(42-17-6-4-5-16(11-17)26-34-9-10-37(26)2)36-28(23(24)31)43-21-12-15(25(32)33)7-8-20(21)38/h4-8,11-12,18-19,35,38H,3,9-10,13-14H2,1-2H3,(H3,32,33)/t18-,19+/m1/s1 AOOVDEATYRPCIJ-MOPGFXCFSA-N 50066639 (2S,4R)-4-{2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3,5-difluoro-6-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)-phenoxy]-pyridin-4-yloxy}-pyrrolidine-2-carboxylic acid ethyl ester::CHEMBL331213 Coagulation factor X Homo sapiens 0.43 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066639&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11801664 103961259 CHEMBL331213 ZINC27106256 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114848 CCOC(=O)CN(C)c1c(F)c(Oc2cccc(c2)C2=NCCN2C)nc(Oc2cc(ccc2O)C(N)=N)c1F InChI=1S/C27H28F2N6O5/c1-4-38-20(37)14-35(3)23-21(28)26(39-17-7-5-6-16(12-17)25-32-10-11-34(25)2)33-27(22(23)29)40-19-13-15(24(30)31)8-9-18(19)36/h5-9,12-13,36H,4,10-11,14H2,1-3H3,(H3,30,31) IPHOQSDIURNFBI-UHFFFAOYSA-N 50066619 ({2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-3,5-difluoro-6-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)-phenoxy]-pyridin-4-yl}-methyl-amino)-acetic acid ethyl ester::CHEMBL333266 Coagulation factor X Homo sapiens 0.26 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066619&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10554769 103961239 CHEMBL333266 ZINC27110080 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114849 CN(C)Cc1cccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(C)c2F)c1 InChI=1S/C22H22F2N4O2/c1-13-18(23)21(29-16-8-4-6-14(10-16)12-28(2)3)27-22(19(13)24)30-17-9-5-7-15(11-17)20(25)26/h4-11H,12H2,1-3H3,(H3,25,26) DQTMNMNOSWBIOY-UHFFFAOYSA-N 50066644 3-[6-(3-Dimethylaminomethyl-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-benzamidine::CHEMBL312378 Coagulation factor X Homo sapiens 640 ChEMBL 10.1021/jm980280h 10.7270/Q2KS6QPR 9733480 Phillips, GB; Buckman, BO; Davey, DD; Eagen, KA; Guilford, WJ; Hinchman, J; Ho, E; Koovakkat, S; Liang, A; Light, DR; Mohan, R; Ng, HP; Post, JM; Shaw, KJ; Smith, D; Subramanyam, B; Sullivan, ME; Trinh, L; Vergona, R; Walters, J; White, K; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066644&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10645345 103961264 CHEMBL312378 ZINC13474010 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114994 NC(=N)NCCCNC(=O)[C@@H]1CS[C@H]2CC[C@@H](NS(=O)(=O)Cc3ccccc3)C(=O)N12 InChI=1S/C19H28N6O4S2/c20-19(21)23-10-4-9-22-17(26)15-11-30-16-8-7-14(18(27)25(15)16)24-31(28,29)12-13-5-2-1-3-6-13/h1-3,5-6,14-16,24H,4,7-12H2,(H,22,26)(H4,20,21,23)/t14-,15+,16+/m1/s1 SOIIHESTBYNJRH-PMPSAXMXSA-N 50066766 (3R,6R,8aS)-5-Oxo-6-phenylmethanesulfonylamino-hexahydro-thiazolo[3,2-a]pyridine-3-carboxylic acid (3-guanidino-propyl)-amide; TFA::CHEMBL120842 Coagulation factor X Homo sapiens 26000 ChEMBL 10.1021/jm981013e 10.7270/Q22R3QSZ 9733491 Wagner, J; Kallen, J; Ehrhardt, C; Evenou, JP; Wagner, D Novartis Pharma AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066766&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search R56 1BHX 444562 103961349 CHEMBL120842 ZINC03832085 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50114999 NC(=N)NCCCNC(=O)[C@@H]1CS[C@H]2CC[C@H](NS(=O)(=O)Cc3ccccc3)C(=O)N12 InChI=1S/C19H28N6O4S2/c20-19(21)23-10-4-9-22-17(26)15-11-30-16-8-7-14(18(27)25(15)16)24-31(28,29)12-13-5-2-1-3-6-13/h1-3,5-6,14-16,24H,4,7-12H2,(H,22,26)(H4,20,21,23)/t14-,15-,16-/m0/s1 SOIIHESTBYNJRH-JYJNAYRXSA-N 50066770 (3R,6S,8aS)-5-Oxo-6-phenylmethanesulfonylamino-hexahydro-thiazolo[3,2-a]pyridine-3-carboxylic acid (3-guanidino-propyl)-amide; TFA::CHEMBL421428 Coagulation factor X Homo sapiens >33700 ChEMBL 10.1021/jm981013e 10.7270/Q22R3QSZ 9733491 Wagner, J; Kallen, J; Ehrhardt, C; Evenou, JP; Wagner, D Novartis Pharma AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066770&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9987204 103961353 CHEMBL421428 ZINC04422981 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50115006 N[C@H]1CC[C@@H]2SC[C@H](N2C1=O)C(=O)NCCCNC(N)=N InChI=1S/C12H22N6O2S/c13-7-2-3-9-18(11(7)20)8(6-21-9)10(19)16-4-1-5-17-12(14)15/h7-9H,1-6,13H2,(H,16,19)(H4,14,15,17)/t7-,8-,9-/m0/s1 QVXJGSMIEKQKJY-CIUDSAMLSA-N 50066771 (3R,6S,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a]pyridine-3-carboxylic acid (3-guanidino-propyl)-amide; TFA::CHEMBL332578 Coagulation factor X Homo sapiens >33700 ChEMBL 10.1021/jm981013e 10.7270/Q22R3QSZ 9733491 Wagner, J; Kallen, J; Ehrhardt, C; Evenou, JP; Wagner, D Novartis Pharma AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066771&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10693808 103961354 CHEMBL332578 ZINC13781162 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50115012 NC(=N)NCCCNC(=O)[C@@H]1CS[C@H]2CC[C@H](NS(=O)(=O)c3cccc4ccccc34)C(=O)N12 InChI=1S/C22H28N6O4S2/c23-22(24)26-12-4-11-25-20(29)17-13-33-19-10-9-16(21(30)28(17)19)27-34(31,32)18-8-3-6-14-5-1-2-7-15(14)18/h1-3,5-8,16-17,19,27H,4,9-13H2,(H,25,29)(H4,23,24,26)/t16-,17-,19-/m0/s1 CJYKZQILFQDAQZ-LNLFQRSKSA-N 50066768 (3R,6S,8aS)-6-(Naphthalene-1-sulfonylamino)-5-oxo-hexahydro-thiazolo[3,2-a]pyridine-3-carboxylic acid (3-guanidino-propyl)-amide; TFA::CHEMBL124042 Coagulation factor X Homo sapiens 17800 ChEMBL 10.1021/jm981013e 10.7270/Q22R3QSZ 9733491 Wagner, J; Kallen, J; Ehrhardt, C; Evenou, JP; Wagner, D Novartis Pharma AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066768&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10841535 103961351 CHEMBL124042 ZINC13781163 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50115013 NC(=N)NCCCNC(=O)[C@@H]1CS[C@H]2CC[C@@H](NS(=O)(=O)c3cccc4ccccc34)C(=O)N12 InChI=1S/C22H28N6O4S2/c23-22(24)26-12-4-11-25-20(29)17-13-33-19-10-9-16(21(30)28(17)19)27-34(31,32)18-8-3-6-14-5-1-2-7-15(14)18/h1-3,5-8,16-17,19,27H,4,9-13H2,(H,25,29)(H4,23,24,26)/t16-,17+,19+/m1/s1 CJYKZQILFQDAQZ-AOIWGVFYSA-N 50066769 (3R,6R,8aS)-6-(Naphthalene-1-sulfonylamino)-5-oxo-hexahydro-thiazolo[3,2-a]pyridine-3-carboxylic acid (3-guanidino-propyl)-amide; TFA::CHEMBL262199 Coagulation factor X Homo sapiens 6780 ChEMBL 10.1021/jm981013e 10.7270/Q22R3QSZ 9733491 Wagner, J; Kallen, J; Ehrhardt, C; Evenou, JP; Wagner, D Novartis Pharma AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066769&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10746409 103961352 CHEMBL262199 ZINC13781160 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50121915 Cc1cc(OCC2CCN(CC2)C(N)=N)cc(OS(=O)(=O)c2ccccc2Cl)c1 InChI=1S/C20H24ClN3O4S/c1-14-10-16(27-13-15-6-8-24(9-7-15)20(22)23)12-17(11-14)28-29(25,26)19-5-3-2-4-18(19)21/h2-5,10-12,15H,6-9,13H2,1H3,(H3,22,23) CYPTUCSRAKRHJR-UHFFFAOYSA-N 50070597 2-Chloro-benzenesulfonic acid 3-(1-carbamimidoyl-piperidin-4-ylmethoxy)-5-methyl-phenyl ester::CHEMBL41876 Coagulation factor X Homo sapiens 80000 ChEMBL 10.1016/s0960-894x(98)00290-x 10.7270/Q20864GK 9873397 Lu, T; Tomczuk, B; Illig, CR; Bone, R; Murphy, L; Spurlino, J; Salemme, FR; Soll, RM 3-Dimensional Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50070597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50070597&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9910982 103964434 CHEMBL41876 ZINC01893773 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50121928 Cc1cc(OCC2CCCN(C2)C(N)=N)cc(OS(=O)(=O)c2ccccc2Cl)c1 InChI=1S/C20H24ClN3O4S/c1-14-9-16(27-13-15-5-4-8-24(12-15)20(22)23)11-17(10-14)28-29(25,26)19-7-3-2-6-18(19)21/h2-3,6-7,9-11,15H,4-5,8,12-13H2,1H3,(H3,22,23) QKGIPJKYFKQJFD-UHFFFAOYSA-N 50070600 2-Chloro-benzenesulfonic acid 3-(1-carbamimidoyl-piperidin-3-ylmethoxy)-5-methyl-phenyl ester::CHEMBL41862 Coagulation factor X Homo sapiens 29000 ChEMBL 10.1016/s0960-894x(98)00290-x 10.7270/Q20864GK 9873397 Lu, T; Tomczuk, B; Illig, CR; Bone, R; Murphy, L; Spurlino, J; Salemme, FR; Soll, RM 3-Dimensional Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50070600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50070600&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44287798 103964437 CHEMBL41862 ZINC03951546 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119301 CC1(C)[C@H]2C[C@@H]1[C@]1(C)OB(O[C@@H]1C2)[C@H](CCCCN)NC(=O)Cn1nc(nc1Cc1ccccc1)-c1cccc(c1)[N+]([O-])=O InChI=1S/C32H41BN6O5/c1-31(2)23-18-25(31)32(3)26(19-23)43-33(44-32)27(14-7-8-15-34)35-29(40)20-38-28(16-21-10-5-4-6-11-21)36-30(37-38)22-12-9-13-24(17-22)39(41)42/h4-6,9-13,17,23,25-27H,7-8,14-16,18-20,34H2,1-3H3,(H,35,40)/t23-,25-,26+,27-,32-/m0/s1 LUIHVBZVTGABOO-XFESLMRKSA-N 50069148 CHEMBL2373347::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-[5-benzyl-3-(3-nitro-phenyl)-[1,2,4]triazol-1-yl]-acetamide Coagulation factor X Homo sapiens 85.0 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069148&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73348764 103963270 CHEMBL2373347 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119302 CC(C)(C)OC(=O)\C=C\c1nc(Cc2ccccc2)n(CC(=O)N[C@@H](CCCCN)B2O[C@@H]3C[C@@H]4C[C@@H](C4(C)C)[C@]3(C)O2)n1 InChI=1S/C33H48BN5O5/c1-31(2,3)42-30(41)16-15-27-37-28(18-22-12-8-7-9-13-22)39(38-27)21-29(40)36-26(14-10-11-17-35)34-43-25-20-23-19-24(32(23,4)5)33(25,6)44-34/h7-9,12-13,15-16,23-26H,10-11,14,17-21,35H2,1-6H3,(H,36,40)/b16-15+/t23-,24-,25+,26-,33-/m0/s1 FMEJXWSFZAAYQP-REPUODOGSA-N 50069147 (E)-3-(1-{[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentylcarbamoyl]-methyl}-5-benzyl-1H-[1,2,4]triazol-3-yl)-acrylic acid tert-butyl ester::CHEMBL2373345 Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069147&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73351857 103963269 CHEMBL2373345 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119304 CC1(C)[C@H]2C[C@@H]1[C@]1(C)OB(O[C@@H]1C2)[C@H](CCCCN)NC(=O)Cn1nc(CC#N)nc1Cc1ccccc1[N+]([O-])=O InChI=1S/C28H38BN7O5/c1-27(2)19-15-21(27)28(3)22(16-19)40-29(41-28)23(10-6-7-12-30)32-26(37)17-35-25(33-24(34-35)11-13-31)14-18-8-4-5-9-20(18)36(38)39/h4-5,8-9,19,21-23H,6-7,10-12,14-17,30H2,1-3H3,(H,32,37)/t19-,21-,22+,23-,28-/m0/s1 YELLYQPFWRBWSX-NYQCOFSNSA-N 50069146 CHEMBL2373405::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-[3-cyanomethyl-5-(2-nitro-benzyl)-[1,2,4]triazol-1-yl]-acetamide Coagulation factor X Homo sapiens 3000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069146&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73350340 103963268 CHEMBL2373405 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119310 CC1(C)[C@H]2C[C@@H]1[C@]1(C)OB(O[C@@H]1C2)[C@H](CCCCN)NC(=O)Cn1nc(nc1Cc1ccccc1)-c1cccc(N)c1 InChI=1S/C32H43BN6O3/c1-31(2)23-18-25(31)32(3)26(19-23)41-33(42-32)27(14-7-8-15-34)36-29(40)20-39-28(16-21-10-5-4-6-11-21)37-30(38-39)22-12-9-13-24(35)17-22/h4-6,9-13,17,23,25-27H,7-8,14-16,18-20,34-35H2,1-3H3,(H,36,40)/t23-,25-,26+,27-,32-/m0/s1 DBDHBRMINWBPKY-XFESLMRKSA-N 50069145 2-[3-(3-Amino-phenyl)-5-benzyl-[1,2,4]triazol-1-yl]-N-[(R)-5-amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-acetamide::CHEMBL2373348 Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069145&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73353327 103963267 CHEMBL2373348 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119311 Cc1nc(Cc2ccccc2)n(CC(=O)N[C@@H](CCCCN)B2O[C@@H]3C[C@@H]4C[C@@H](C4(C)C)[C@]3(C)O2)n1 InChI=1S/C27H40BN5O3/c1-18-30-24(14-19-10-6-5-7-11-19)33(32-18)17-25(34)31-23(12-8-9-13-29)28-35-22-16-20-15-21(26(20,2)3)27(22,4)36-28/h5-7,10-11,20-23H,8-9,12-17,29H2,1-4H3,(H,31,34)/t20-,21-,22+,23-,27-/m0/s1 PTJNGQGAFPGNOH-LHAUQXRRSA-N 50069156 CHEMBL2373349::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-(5-benzyl-3-methyl-[1,2,4]triazol-1-yl)-acetamide Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069156&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73348765 103963278 CHEMBL2373349 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119312 CC1(C)[C@H]2C[C@@H]1[C@]1(C)OB(O[C@@H]1C2)[C@H](CCCCN)NC(=O)Cn1nc(Cc2ccccc2)nc1Cc1ccccc1 InChI=1S/C33H44BN5O3/c1-32(2)25-20-26(32)33(3)27(21-25)41-34(42-33)28(16-10-11-17-35)36-31(40)22-39-30(19-24-14-8-5-9-15-24)37-29(38-39)18-23-12-6-4-7-13-23/h4-9,12-15,25-28H,10-11,16-22,35H2,1-3H3,(H,36,40)/t25-,26-,27+,28-,33-/m0/s1 OFGYDRFDYOFDAH-KAGPHYKASA-N 50069157 CHEMBL2373401::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-(3,5-dibenzyl-[1,2,4]triazol-1-yl)-acetamide Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069157&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73350338 103963279 CHEMBL2373401 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119314 CC1(C)[C@H]2C[C@@H]1[C@]1(C)OB(O[C@@H]1C2)[C@H](CCCCN)NC(=O)Cn1nc(CC#N)nc1Cc1ccccc1 InChI=1S/C28H39BN6O3/c1-27(2)20-16-21(27)28(3)22(17-20)37-29(38-28)23(11-7-8-13-30)32-26(36)18-35-25(33-24(34-35)12-14-31)15-19-9-5-4-6-10-19/h4-6,9-10,20-23H,7-8,11-13,15-18,30H2,1-3H3,(H,32,36)/t20-,21-,22+,23-,28-/m0/s1 CTJBFJRLIYRRCN-BMILHVPESA-N 50069159 CHEMBL2375178::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-(5-benzyl-3-cyanomethyl-[1,2,4]triazol-1-yl)-acetamide Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069159&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73354863 103963281 CHEMBL2375178 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119318 CC1(C)[C@H]2C[C@@H]1[C@]1(C)OB(O[C@@H]1C2)[C@H](CCCCN)NC(=O)Cn1nc(CC(O)=O)nc1Cc1ccccc1 InChI=1S/C28H40BN5O5/c1-27(2)19-14-20(27)28(3)21(15-19)38-29(39-28)22(11-7-8-12-30)31-25(35)17-34-24(13-18-9-5-4-6-10-18)32-23(33-34)16-26(36)37/h4-6,9-10,19-22H,7-8,11-17,30H2,1-3H3,(H,31,35)(H,36,37)/t19-,20-,21+,22-,28-/m0/s1 PCUFEQVMXQHWBV-DDUQIEEJSA-N 50069160 (1-{[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentylcarbamoyl]-methyl}-5-benzyl-1H-[1,2,4]triazol-3-yl)-acetic acid::CHEMBL2373404 Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069160&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73345767 103963282 CHEMBL2373404 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119342 CC1(C)[C@H]2C[C@@H]1[C@]1(C)OB(O[C@@H]1C2)[C@H](CCCCN)NC(=O)Cn1nc(CNC=O)nc1Cc1ccccc1 InChI=1S/C28H41BN6O4/c1-27(2)20-14-21(27)28(3)22(15-20)38-29(39-28)23(11-7-8-12-30)32-26(37)17-35-25(13-19-9-5-4-6-10-19)33-24(34-35)16-31-18-36/h4-6,9-10,18,20-23H,7-8,11-17,30H2,1-3H3,(H,31,36)(H,32,37)/t20-,21-,22+,23-,28-/m0/s1 MWJAQZALXIOOQS-BMILHVPESA-N 50069143 CHEMBL2373559::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-(5-benzyl-3-formylaminomethyl-[1,2,4]triazol-1-yl)-acetamide Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069143&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73353330 103963265 CHEMBL2373559 C06049 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119343 CC1(C)[C@H]2C[C@@H]1[C@]1(C)OB(O[C@@H]1C2)[C@H](CCCCN)NC(=O)Cn1nc(CCC(O)=O)nc1Cc1ccccc1 InChI=1S/C29H42BN5O5/c1-28(2)20-16-21(28)29(3)22(17-20)39-30(40-29)23(11-7-8-14-31)32-26(36)18-35-25(15-19-9-5-4-6-10-19)33-24(34-35)12-13-27(37)38/h4-6,9-10,20-23H,7-8,11-18,31H2,1-3H3,(H,32,36)(H,37,38)/t20-,21-,22+,23-,29-/m0/s1 CEXXVNUPCUBEML-QLJXJWLFSA-N 50069163 3-(1-{[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentylcarbamoyl]-methyl}-5-benzyl-1H-[1,2,4]triazol-3-yl)-propionic acid::CHEMBL2373400 Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069163&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73354849 103963285 CHEMBL2373400 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119348 CC(C)(C)CC(=O)NCc1nc(Cc2ccccc2)n(CC(=O)N[C@@H](CCCCN)B2O[C@@H]3C[C@@H]4C[C@@H](C4(C)C)[C@]3(C)O2)n1 InChI=1S/C33H51BN6O4/c1-31(2,3)19-29(41)36-20-27-38-28(16-22-12-8-7-9-13-22)40(39-27)21-30(42)37-26(14-10-11-15-35)34-43-25-18-23-17-24(32(23,4)5)33(25,6)44-34/h7-9,12-13,23-26H,10-11,14-21,35H2,1-6H3,(H,36,41)(H,37,42)/t23-,24-,25+,26-,33-/m0/s1 UZMQVFWUMDZRLA-SFZNBDKLSA-N 50069158 CHEMBL2373440::N-(1-{[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentylcarbamoyl]-methyl}-5-benzyl-1H-[1,2,4]triazol-3-ylmethyl)-3,3-dimethyl-butyramide Coagulation factor X Homo sapiens 4300 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069158&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73354850 103963280 CHEMBL2373440 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119352 COC(=O)Cc1nc(Cc2ccccc2)n(CC(=O)N[C@@H](CCCCN)B2O[C@@H]3C[C@@H]4C[C@@H](C4(C)C)[C@]3(C)O2)n1 InChI=1S/C29H42BN5O5/c1-28(2)20-15-21(28)29(3)22(16-20)39-30(40-29)23(12-8-9-13-31)32-26(36)18-35-25(14-19-10-6-5-7-11-19)33-24(34-35)17-27(37)38-4/h5-7,10-11,20-23H,8-9,12-18,31H2,1-4H3,(H,32,36)/t20-,21-,22+,23-,29-/m0/s1 ONNPVMQMNAGBTO-QLJXJWLFSA-N 50069153 (1-{[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentylcarbamoyl]-methyl}-5-benzyl-1H-[1,2,4]triazol-3-yl)-acetic acid methyl ester::CHEMBL2373555 Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069153&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73345771 103963275 CHEMBL2373555 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119361 CC1(C)[C@H]2C[C@@H]1[C@]1(C)OB(O[C@@H]1C2)[C@H](CCCCN)NC(=O)Cn1nc(COCc2ccccc2)nc1Cc1ccccc1 InChI=1S/C34H46BN5O4/c1-33(2)26-19-27(33)34(3)28(20-26)43-35(44-34)29(16-10-11-17-36)37-32(41)21-40-31(18-24-12-6-4-7-13-24)38-30(39-40)23-42-22-25-14-8-5-9-15-25/h4-9,12-15,26-29H,10-11,16-23,36H2,1-3H3,(H,37,41)/t26-,27-,28+,29-,34-/m0/s1 KXVNPJHKDAQTEB-VTFYTQQRSA-N 50069161 CHEMBL2373344::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-(5-benzyl-3-benzyloxymethyl-[1,2,4]triazol-1-yl)-acetamide Coagulation factor X Homo sapiens 1600 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069161&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73351856 103963283 CHEMBL2373344 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119364 CSCc1nc(Cc2ccccc2)n(CC(=O)N[C@@H](CCCCN)B2O[C@@H]3C[C@@H]4C[C@@H](C4(C)C)[C@]3(C)O2)n1 InChI=1S/C28H42BN5O3S/c1-27(2)20-15-21(27)28(3)22(16-20)36-29(37-28)23(12-8-9-13-30)31-26(35)17-34-25(32-24(33-34)18-38-4)14-19-10-6-5-7-11-19/h5-7,10-11,20-23H,8-9,12-18,30H2,1-4H3,(H,31,35)/t20-,21-,22+,23-,28-/m0/s1 PEWZOLRZXLOXMI-BMILHVPESA-N 50069152 CHEMBL2373350::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-(5-benzyl-3-methylsulfanylmethyl-[1,2,4]triazol-1-yl)-acetamide Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069152&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73353328 103963274 CHEMBL2373350 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119368 CC1(C)[C@H]2C[C@@H]1[C@]1(C)OB(O[C@@H]1C2)[C@H](CCCCN)NC(=O)Cn1nc(CC#N)cc1CCc1ccccc1 InChI=1S/C30H42BN5O3/c1-29(2)22-17-25(29)30(3)26(18-22)38-31(39-30)27(11-7-8-15-32)34-28(37)20-36-24(19-23(35-36)14-16-33)13-12-21-9-5-4-6-10-21/h4-6,9-10,19,22,25-27H,7-8,11-15,17-18,20,32H2,1-3H3,(H,34,37)/t22-,25-,26+,27-,30-/m0/s1 UGKVIJMVQRJDEZ-OZJCNNKCSA-N 50069162 CHEMBL2373351::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-(3-cyanomethyl-5-phenethyl-pyrazol-1-yl)-acetamide Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069162&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73354848 103963284 CHEMBL2373351 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119369 CC1(C)[C@H]2C[C@@H]1[C@]1(C)OB(O[C@@H]1C2)[C@H](CCCCN)NC(=O)Cn1nc(CO)nc1Cc1ccccc1 InChI=1S/C27H40BN5O4/c1-26(2)19-14-20(26)27(3)21(15-19)36-28(37-27)22(11-7-8-12-29)30-25(35)16-33-24(31-23(17-34)32-33)13-18-9-5-4-6-10-18/h4-6,9-10,19-22,34H,7-8,11-17,29H2,1-3H3,(H,30,35)/t19-,20-,21+,22-,27-/m0/s1 MTEQHLOAHWLAMX-AWZWVWSRSA-N 50069171 CHEMBL2373341::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-(5-benzyl-3-hydroxymethyl-[1,2,4]triazol-1-yl)-acetamide Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069171&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73351853 103963293 CHEMBL2373341 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119370 CC(C)(C)OC(=O)CCc1nc(Cc2ccccc2)n(CC(=O)N[C@@H](CCCCN)B2O[C@@H]3C[C@@H]4C[C@@H](C4(C)C)[C@]3(C)O2)n1 InChI=1S/C33H50BN5O5/c1-31(2,3)42-30(41)16-15-27-37-28(18-22-12-8-7-9-13-22)39(38-27)21-29(40)36-26(14-10-11-17-35)34-43-25-20-23-19-24(32(23,4)5)33(25,6)44-34/h7-9,12-13,23-26H,10-11,14-21,35H2,1-6H3,(H,36,40)/t23-,24-,25+,26-,33-/m0/s1 UPQDIVVNVJRVNI-SFZNBDKLSA-N 50069154 3-(1-{[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentylcarbamoyl]-methyl}-5-benzyl-1H-[1,2,4]triazol-3-yl)-propionic acid tert-butyl ester::CHEMBL2373367 Coagulation factor X Homo sapiens 5.50 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069154&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73348767 103963276 CHEMBL2373367 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119376 CCCc1nc(Cc2ccccc2)n(CC(=O)N[C@@H](CCCCN)B2O[C@@H]3C[C@@H]4C[C@@H](C4(C)C)[C@]3(C)O2)n1 InChI=1S/C29H44BN5O3/c1-5-11-25-33-26(16-20-12-7-6-8-13-20)35(34-25)19-27(36)32-24(14-9-10-15-31)30-37-23-18-21-17-22(28(21,2)3)29(23,4)38-30/h6-8,12-13,21-24H,5,9-11,14-19,31H2,1-4H3,(H,32,36)/t21-,22-,23+,24-,29-/m0/s1 IJPKHEGDEHMVNS-UMWNSNATSA-N 50069149 CHEMBL2373402::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-(5-benzyl-3-propyl-[1,2,4]triazol-1-yl)-acetamide Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069149&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73350339 103963271 CHEMBL2373402 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119377 CC1(C)[C@H]2C[C@@H]1[C@]1(C)OB(O[C@@H]1C2)[C@H](CCCCN)NC(=O)Cn1nc(CNS(=O)(=O)C(F)(F)F)nc1Cc1ccccc1 InChI=1S/C28H40BF3N6O5S/c1-26(2)19-14-20(26)27(3)21(15-19)42-29(43-27)22(11-7-8-12-33)35-25(39)17-38-24(13-18-9-5-4-6-10-18)36-23(37-38)16-34-44(40,41)28(30,31)32/h4-6,9-10,19-22,34H,7-8,11-17,33H2,1-3H3,(H,35,39)/t19-,20-,21+,22-,27-/m0/s1 NDSNEDZTXHWRDJ-AWZWVWSRSA-N 50069155 CHEMBL2373302::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-[5-benzyl-3-(trifluoromethanesulfonylamino-methyl)-[1,2,4]triazol-1-yl]-acetamide Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069155&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73348759 103963277 CHEMBL2373302 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119379 C[S+]([O-])Cc1nc(Cc2ccccc2)n(CC(=O)N[C@@H](CCCCN)B2O[C@@H]3C[C@@H]4C[C@@H](C4(C)C)[C@]3(C)O2)n1 InChI=1S/C28H42BN5O4S/c1-27(2)20-15-21(27)28(3)22(16-20)37-29(38-28)23(12-8-9-13-30)31-26(35)17-34-25(14-19-10-6-5-7-11-19)32-24(33-34)18-39(4)36/h5-7,10-11,20-23H,8-9,12-18,30H2,1-4H3,(H,31,35)/t20-,21-,22+,23-,28-,39?/m0/s1 OCGKHKOQHRZKIM-BXGSKYBCSA-N 50069166 CHEMBL2373475::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-(5-benzyl-3-methanesulfinylmethyl-[1,2,4]triazol-1-yl)-acetamide Coagulation factor X Homo sapiens 6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069166&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73356390 103963288 CHEMBL2373475 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119384 CC(C)C(=O)NCc1nc(Cc2ccccc2)n(CC(=O)N[C@@H](CCCCN)B2O[C@@H]3C[C@@H]4C[C@@H](C4(C)C)[C@]3(C)O2)n1 InChI=1S/C31H47BN6O4/c1-20(2)29(40)34-18-26-36-27(15-21-11-7-6-8-12-21)38(37-26)19-28(39)35-25(13-9-10-14-33)32-41-24-17-22-16-23(30(22,3)4)31(24,5)42-32/h6-8,11-12,20,22-25H,9-10,13-19,33H2,1-5H3,(H,34,40)(H,35,39)/t22-,23-,24+,25-,31-/m0/s1 ZSGGXQZFQUHUPY-IKNSMAACSA-N 50069165 CHEMBL2373346::N-(1-{[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentylcarbamoyl]-methyl}-5-benzyl-1H-[1,2,4]triazol-3-ylmethyl)-isobutyramide Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069165&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73353326 103963287 CHEMBL2373346 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119387 CC1(C)[C@H]2C[C@@H]1[C@]1(C)OB(O[C@@H]1C2)[C@H](CCCCN)NC(=O)Cn1nc(CC#N)nc1Cc1cccc(c1)[N+]([O-])=O InChI=1S/C28H38BN7O5/c1-27(2)19-15-21(27)28(3)22(16-19)40-29(41-28)23(9-4-5-11-30)32-26(37)17-35-25(33-24(34-35)10-12-31)14-18-7-6-8-20(13-18)36(38)39/h6-8,13,19,21-23H,4-5,9-11,14-17,30H2,1-3H3,(H,32,37)/t19-,21-,22+,23-,28-/m0/s1 XXDNJRMCHPIHOV-NYQCOFSNSA-N 50069173 CHEMBL2373403::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-[3-cyanomethyl-5-(3-nitro-benzyl)-[1,2,4]triazol-1-yl]-acetamide Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069173&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73345766 103963295 CHEMBL2373403 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119390 CC1(C)[C@H]2C[C@@H]1[C@]1(C)OB(O[C@@H]1C2)[C@H](CCCCN)NC(=O)Cn1nc(CC#N)nc1CCc1ccccc1 InChI=1S/C29H41BN6O3/c1-28(2)21-17-22(28)29(3)23(18-21)38-30(39-29)24(11-7-8-15-31)33-27(37)19-36-26(34-25(35-36)14-16-32)13-12-20-9-5-4-6-10-20/h4-6,9-10,21-24H,7-8,11-15,17-19,31H2,1-3H3,(H,33,37)/t21-,22-,23+,24-,29-/m0/s1 MURLAVKNQRRIBB-UMWNSNATSA-N 50069150 CHEMBL2373408::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-(3-cyanomethyl-5-phenethyl-[1,2,4]triazol-1-yl)-acetamide Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069150&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73350342 103963272 CHEMBL2373408 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119395 CC1(C)[C@H]2C[C@@H]1[C@]1(C)OB(O[C@@H]1C2)[C@H](CCCCN)NC(=O)Cn1nc(CS(C)(=O)=O)nc1Cc1ccccc1 InChI=1S/C28H42BN5O5S/c1-27(2)20-15-21(27)28(3)22(16-20)38-29(39-28)23(12-8-9-13-30)31-26(35)17-34-25(14-19-10-6-5-7-11-19)32-24(33-34)18-40(4,36)37/h5-7,10-11,20-23H,8-9,12-18,30H2,1-4H3,(H,31,35)/t20-,21-,22+,23-,28-/m0/s1 QOLVMRURXPRFJX-BMILHVPESA-N 50069151 CHEMBL2373397::N-[(R)-5-Amino-1-((1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0*2,6*]dec-4-yl)-pentyl]-2-(5-benzyl-3-methanesulfonylmethyl-[1,2,4]triazol-1-yl)-acetamide Coagulation factor X Homo sapiens >6000 ChEMBL 10.1016/s0960-894x(98)00104-8 10.7270/Q2P84B1P 9871540 Duncia, JV; Santella, JB; Higley, CA; VanAtten, MK; Weber, PC; Alexander, RS; Kettner, CA; Pruitt, JR; Liauw, AY; Quan, ML; Knabb, RM; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069151&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 73345765 103963273 CHEMBL2373397 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120653 CC(C)(CN(CC(=O)NC(CCCNC(N)=N)B(O)O)C(=O)CCc1ccccc1)c1ccccc1 InChI=1S/C26H38BN5O4/c1-26(2,21-12-7-4-8-13-21)19-32(24(34)16-15-20-10-5-3-6-11-20)18-23(33)31-22(27(35)36)14-9-17-30-25(28)29/h3-8,10-13,22,35-36H,9,14-19H2,1-2H3,(H,31,33)(H4,28,29,30) AHVRHIQTLPAZHX-UHFFFAOYSA-N 50069926 Boropeptide analogue::CHEMBL105137 Coagulation factor X Homo sapiens 99 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069926&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44334264 103963888 CHEMBL105137 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120654 OB(O)C(CCCNC=N)NC(=O)CN(CC1(CCCC1)c1ccccc1)C(=O)CCc1ccccc1 InChI=1S/C28H39BN4O4/c30-22-31-19-9-14-25(29(36)37)32-26(34)20-33(27(35)16-15-23-10-3-1-4-11-23)21-28(17-7-8-18-28)24-12-5-2-6-13-24/h1-6,10-13,22,25,36-37H,7-9,14-21H2,(H2,30,31)(H,32,34) YNXJBBUWTCLOKJ-UHFFFAOYSA-N 50069927 Boropeptide analogue::CHEMBL102930 Coagulation factor X Homo sapiens 630 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069927&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44334318 103963889 CHEMBL102930 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120658 NCCCCC(NC(=O)CN(CC1(CC1)c1ccccc1)C(=O)CCc1ccccc1)B(O)O InChI=1S/C26H36BN3O4/c28-18-8-7-13-23(27(33)34)29-24(31)19-30(25(32)15-14-21-9-3-1-4-10-21)20-26(16-17-26)22-11-5-2-6-12-22/h1-6,9-12,23,33-34H,7-8,13-20,28H2,(H,29,31) RDRHNQRAGYVVLX-UHFFFAOYSA-N 50069930 Boropeptide analogue::CHEMBL320019 Coagulation factor X Homo sapiens 438 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069930&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44333992 103963892 CHEMBL320019 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120659 CC(C)(CN(CC(=O)NC(CCCCN)B(O)O)C(=O)CCc1ccccc1)c1ccccc1 InChI=1S/C26H38BN3O4/c1-26(2,22-13-7-4-8-14-22)20-30(25(32)17-16-21-11-5-3-6-12-21)19-24(31)29-23(27(33)34)15-9-10-18-28/h3-8,11-14,23,33-34H,9-10,15-20,28H2,1-2H3,(H,29,31) IWAQYXMBYJRGPV-UHFFFAOYSA-N 50069931 Boropeptide analogue::CHEMBL105212 Coagulation factor X Homo sapiens 320 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069931&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44334002 103963893 CHEMBL105212 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120661 Cc1cc(C)cc(c1)C(C)(C)CN(CC(=O)NC(CCCNC=N)B(O)O)C(=O)CCc1ccccc1 InChI=1S/C28H41BN4O4/c1-21-15-22(2)17-24(16-21)28(3,4)19-33(27(35)13-12-23-9-6-5-7-10-23)18-26(34)32-25(29(36)37)11-8-14-31-20-30/h5-7,9-10,15-17,20,25,36-37H,8,11-14,18-19H2,1-4H3,(H2,30,31)(H,32,34) DYGABVBZUCBNDS-UHFFFAOYSA-N 50069929 Boropeptide analogue::CHEMBL103078 Coagulation factor X Homo sapiens 392 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069929&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44334316 103963891 CHEMBL103078 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120663 Cc1cc(C)cc(CCN(CC(=O)NC(CCCCN)B(O)O)C(=O)CCc2ccccc2)c1 InChI=1S/C26H38BN3O4/c1-20-16-21(2)18-23(17-20)13-15-30(26(32)12-11-22-8-4-3-5-9-22)19-25(31)29-24(27(33)34)10-6-7-14-28/h3-5,8-9,16-18,24,33-34H,6-7,10-15,19,28H2,1-2H3,(H,29,31) MDGAHOUIOJEGBC-UHFFFAOYSA-N 50069933 Boropeptide analogue::CHEMBL102916 Coagulation factor X Homo sapiens 54 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069933&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44334374 103963895 CHEMBL102916 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120672 CC(C)(CN(CC(=O)NC(CCCNC=N)B(O)O)C(=O)CCc1ccccc1)c1ccccc1 InChI=1S/C26H37BN4O4/c1-26(2,22-12-7-4-8-13-22)19-31(25(33)16-15-21-10-5-3-6-11-21)18-24(32)30-23(27(34)35)14-9-17-29-20-28/h3-8,10-13,20,23,34-35H,9,14-19H2,1-2H3,(H2,28,29)(H,30,32) LTVJYZXRRBSKBE-UHFFFAOYSA-N 50069925 Boropeptide analogue::CHEMBL317639 Coagulation factor X Homo sapiens 80 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069925&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44333951 103963887 CHEMBL317639 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120676 NCCCCC(NC(=O)CN(CCc1ccccc1)C(=O)CCc1ccccc1)B(O)O InChI=1S/C24H34BN3O4/c26-17-8-7-13-22(25(31)32)27-23(29)19-28(18-16-21-11-5-2-6-12-21)24(30)15-14-20-9-3-1-4-10-20/h1-6,9-12,22,31-32H,7-8,13-19,26H2,(H,27,29) FVEMXCSGNPVPIT-UHFFFAOYSA-N 50069924 Boropeptide analogue::CHEMBL419734 Coagulation factor X Homo sapiens 130 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069924&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44334003 103963886 CHEMBL419734 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120679 Cc1cc(C)cc(c1)C(C)(C)CN(CC(=O)NC(CCCCN)B(O)O)C(=O)CCc1ccccc1 InChI=1S/C28H42BN3O4/c1-21-16-22(2)18-24(17-21)28(3,4)20-32(27(34)14-13-23-10-6-5-7-11-23)19-26(33)31-25(29(35)36)12-8-9-15-30/h5-7,10-11,16-18,25,35-36H,8-9,12-15,19-20,30H2,1-4H3,(H,31,33) NNDZBMZJIBCTOP-UHFFFAOYSA-N 50069936 Boropeptide analogue::CHEMBL319050 Coagulation factor X Homo sapiens 810 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069936&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44334382 103963898 CHEMBL319050 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120681 Cc1cc(C)cc(c1)C(C)(C)CN(CC(=O)NC(CCCNC(N)=N)B(O)O)C(=O)CCc1ccccc1 InChI=1S/C28H42BN5O4/c1-20-15-21(2)17-23(16-20)28(3,4)19-34(26(36)13-12-22-9-6-5-7-10-22)18-25(35)33-24(29(37)38)11-8-14-32-27(30)31/h5-7,9-10,15-17,24,37-38H,8,11-14,18-19H2,1-4H3,(H,33,35)(H4,30,31,32) ALTLFQNJHQZNKO-UHFFFAOYSA-N 50069935 Boropeptide analogue::CHEMBL320213 Coagulation factor X Homo sapiens 62 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069935&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44334314 103963897 CHEMBL320213 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120683 Cc1cc(C)cc(CCN(CC(=O)NC(CCCNC=N)B(O)O)C(=O)CCc2ccccc2)c1 InChI=1S/C26H37BN4O4/c1-20-15-21(2)17-23(16-20)12-14-31(26(33)11-10-22-7-4-3-5-8-22)18-25(32)30-24(27(34)35)9-6-13-29-19-28/h3-5,7-8,15-17,19,24,34-35H,6,9-14,18H2,1-2H3,(H2,28,29)(H,30,32) DDCLHNTVVUNFED-UHFFFAOYSA-N 50069937 Boropeptide analogue::CHEMBL102779 Coagulation factor X Homo sapiens 30 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069937&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44334554 103963899 CHEMBL102779 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120684 NC(=N)NCCCC(NC(=O)CN(CC1(CC1)c1ccccc1)C(=O)CCc1ccccc1)B(O)O InChI=1S/C26H36BN5O4/c28-25(29)30-17-7-12-22(27(35)36)31-23(33)18-32(24(34)14-13-20-8-3-1-4-9-20)19-26(15-16-26)21-10-5-2-6-11-21/h1-6,8-11,22,35-36H,7,12-19H2,(H,31,33)(H4,28,29,30) DSVGBRXCGKCTSK-UHFFFAOYSA-N 50069928 Boropeptide analogue::CHEMBL102385 Coagulation factor X Homo sapiens 46 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069928&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44334242 103963890 CHEMBL102385 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120690 OB(O)C(CCCNC=N)NC(=O)CN(CCc1ccccc1)C(=O)CCc1ccccc1 InChI=1S/C24H33BN4O4/c26-19-27-16-7-12-22(25(32)33)28-23(30)18-29(17-15-21-10-5-2-6-11-21)24(31)14-13-20-8-3-1-4-9-20/h1-6,8-11,19,22,32-33H,7,12-18H2,(H2,26,27)(H,28,30) IGRCAZNQYXPQOS-UHFFFAOYSA-N 50069932 Boropeptide analogue::CHEMBL105393 Coagulation factor X Homo sapiens 22 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069932&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44333972 103963894 CHEMBL105393 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120695 OB(O)C(CCCNC=N)NC(=O)CN(CC1(CC1)c1ccccc1)C(=O)CCc1ccccc1 InChI=1S/C26H35BN4O4/c28-20-29-17-7-12-23(27(34)35)30-24(32)18-31(25(33)14-13-21-8-3-1-4-9-21)19-26(15-16-26)22-10-5-2-6-11-22/h1-6,8-11,20,23,34-35H,7,12-19H2,(H2,28,29)(H,30,32) AQOWADPLFQHPQP-UHFFFAOYSA-N 50069923 Boropeptide analogue::CHEMBL104331 Coagulation factor X Homo sapiens 300 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069923&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44334349 103963885 CHEMBL104331 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120697 NCCCCC(NC(=O)CN(CC1(CCCC1)c1ccccc1)C(=O)CCc1ccccc1)B(O)O InChI=1S/C28H40BN3O4/c30-20-10-7-15-25(29(35)36)31-26(33)21-32(27(34)17-16-23-11-3-1-4-12-23)22-28(18-8-9-19-28)24-13-5-2-6-14-24/h1-6,11-14,25,35-36H,7-10,15-22,30H2,(H,31,33) NGKBEHNBFCCOSR-UHFFFAOYSA-N 50069934 Boropeptide analogue::CHEMBL431056 Coagulation factor X Homo sapiens 1390 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069934&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44333960 103963896 CHEMBL431056 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50120699 Cc1cc(C)cc(CCN(CC(=O)NC(CCCNC(N)=N)B(O)O)C(=O)CCc2ccccc2)c1 InChI=1S/C26H38BN5O4/c1-19-15-20(2)17-22(16-19)12-14-32(25(34)11-10-21-7-4-3-5-8-21)18-24(33)31-23(27(35)36)9-6-13-30-26(28)29/h3-5,7-8,15-17,23,35-36H,6,9-14,18H2,1-2H3,(H,31,33)(H4,28,29,30) AGSWZHNILZKCTF-UHFFFAOYSA-N 50069938 Boropeptide analogue::CHEMBL103077 Coagulation factor X Homo sapiens 15 ChEMBL 10.1016/s0960-894x(98)00013-4 10.7270/Q2542MRM 9871674 Fevig, JM; Buriak, J; Cacciola, J; Alexander, RS; Kettner, CA; Knabb, RM; Pruitt, JR; Weber, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069938&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44334315 103963900 CHEMBL103077 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50119693 CN(C1CCCC1)C(=O)[C@H](Cc1ccc(cc1)C(N)=NN)NS(=O)(=O)c1ccc2ccccc2c1 InChI=1S/C26H31N5O3S/c1-31(22-8-4-5-9-22)26(32)24(16-18-10-12-20(13-11-18)25(27)29-28)30-35(33,34)23-15-14-19-6-2-3-7-21(19)17-23/h2-3,6-7,10-15,17,22,24,30H,4-5,8-9,16,28H2,1H3,(H2,27,29)/t24-/m0/s1 ZPDICRPCOSQEDS-DEOSSOPVSA-N 50069294 (S)-3-[4-(carbohydrazonamidol)-phenyl]-N-cyclopentyl-N-methyl-2-(naphthalene-2-sulfonylamino)-propionamide::(S)-5-(4-Methylamino-phenyl)-2-(5,6,7,8-tetrahydro-naphthalene-2-sulfonylamino)-pent-4-ynoic acid cyclopentylamide::1N-cyclopentyl-1N-methyl-3-(4-Carbohydrazonamidephenyl)-2-(2-naphthylsulfonamido)-(2S)-propanamide::1N-cyclopentyl-3-[4-amino(aminoimino)methylphenyl]-2-(2-naphthylsulfinamido)propanamide::Benzamidrazone analogue::CHEMBL7962::N-methyl-N-cyclopentyl-3-(4-hydrazonoformamidephenyl)-2-[(2-naphthylsulfonyl)amino]propanamide Coagulation factor X Homo sapiens 1100 ChEMBL 10.1016/s0960-894x(98)00079-1 10.7270/Q2CR5SHR 9871573 Oh, YS; Yun, M; Hwang, SY; Hong, S; Shin, Y; Lee, K; Yoon, KH; Yoo, YJ; Kim, DS; Lee, SH; Lee, YH; Park, HD; Lee, CH; Lee, SK; Kim, S Biotech Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069294&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9913629 103963402 CHEMBL7962 ZINC03928465 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50121893 Cc1cc(OCCCCCNC(N)=N)cc(OS(=O)(=O)c2ccccc2Cl)c1 InChI=1S/C19H24ClN3O4S/c1-14-11-15(26-10-6-2-5-9-23-19(21)22)13-16(12-14)27-28(24,25)18-8-4-3-7-17(18)20/h3-4,7-8,11-13H,2,5-6,9-10H2,1H3,(H4,21,22,23) PZDQWFGROZEEBN-UHFFFAOYSA-N 50070595 2-Chloro-benzenesulfonic acid 3-(5-guanidino-pentyloxy)-5-methyl-phenyl ester::CHEMBL287910 Coagulation factor X Homo sapiens 120000 ChEMBL 10.1016/s0960-894x(98)00290-x 10.7270/Q20864GK 9873397 Lu, T; Tomczuk, B; Illig, CR; Bone, R; Murphy, L; Spurlino, J; Salemme, FR; Soll, RM 3-Dimensional Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50070595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50070595&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44287797 103964432 CHEMBL287910 ZINC29341876 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50121897 Cc1cc(OCCCCNC(N)=N)cc(OS(=O)(=O)c2ccccc2Cl)c1 InChI=1S/C18H22ClN3O4S/c1-13-10-14(25-9-5-4-8-22-18(20)21)12-15(11-13)26-27(23,24)17-7-3-2-6-16(17)19/h2-3,6-7,10-12H,4-5,8-9H2,1H3,(H4,20,21,22) PVSDNGWLTSTWIU-UHFFFAOYSA-N 50070599 2-Chloro-benzenesulfonic acid 3-(4-guanidino-butoxy)-5-methyl-phenyl ester::CHEMBL287807 Coagulation factor X Homo sapiens 110000 ChEMBL 10.1016/s0960-894x(98)00290-x 10.7270/Q20864GK 9873397 Lu, T; Tomczuk, B; Illig, CR; Bone, R; Murphy, L; Spurlino, J; Salemme, FR; Soll, RM 3-Dimensional Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50070599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50070599&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44288029 103964436 CHEMBL287807 ZINC29343843 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50121900 CN(CCOc1cc(C)cc(OS(=O)(=O)c2ccccc2Cl)c1)c1ccncc1 InChI=1S/C21H21ClN2O4S/c1-16-13-18(27-12-11-24(2)17-7-9-23-10-8-17)15-19(14-16)28-29(25,26)21-6-4-3-5-20(21)22/h3-10,13-15H,11-12H2,1-2H3 MOAKYEVSWZWMBB-UHFFFAOYSA-N 50064653 2-Chloro-benzenesulfonic acid 3-methyl-5-[2-(methyl-pyridin-4-yl-amino)-ethoxy]-phenyl ester::CHEMBL289951 Coagulation factor X Homo sapiens 160000 ChEMBL 10.1016/s0960-894x(98)00290-x 10.7270/Q20864GK 9873397 Lu, T; Tomczuk, B; Illig, CR; Bone, R; Murphy, L; Spurlino, J; Salemme, FR; Soll, RM 3-Dimensional Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50064653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50064653&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10094378 103959635 CHEMBL289951 ZINC13779736 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50121909 Cc1cc(OCCCNC(N)=N)cc(OS(=O)(=O)c2ccccc2Cl)c1 InChI=1S/C17H20ClN3O4S/c1-12-9-13(24-8-4-7-21-17(19)20)11-14(10-12)25-26(22,23)16-6-3-2-5-15(16)18/h2-3,5-6,9-11H,4,7-8H2,1H3,(H4,19,20,21) CVEUGTDNSRXYGZ-UHFFFAOYSA-N 50070598 2-Chloro-benzenesulfonic acid 3-(3-guanidino-propoxy)-5-methyl-phenyl ester::CHEMBL291062 Coagulation factor X Homo sapiens >200000 ChEMBL 10.1016/s0960-894x(98)00290-x 10.7270/Q20864GK 9873397 Lu, T; Tomczuk, B; Illig, CR; Bone, R; Murphy, L; Spurlino, J; Salemme, FR; Soll, RM 3-Dimensional Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50070598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50070598&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44287937 103964435 CHEMBL291062 ZINC29346802 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50124261 NC(=N)c1cccc(c1)N1CCCN(C2CCN(Cc3ccccc3)CC2)C1=O InChI=1S/C23H29N5O/c24-22(25)19-8-4-9-21(16-19)28-13-5-12-27(23(28)29)20-10-14-26(15-11-20)17-18-6-2-1-3-7-18/h1-4,6-9,16,20H,5,10-15,17H2,(H3,24,25) WQVRWEUKPWWBBM-UHFFFAOYSA-N 50071941 3-[3-(1-Benzyl-piperidin-4-yl)-2-oxo-tetrahydro-pyrimidin-1-yl]-benzamidine::CHEMBL329127 Coagulation factor X Homo sapiens 400 ChEMBL 10.1016/s0960-894x(98)00471-5 10.7270/Q23R0S13 9873607 Galemmo, RA; Maduskuie, TP; Dominguez, C; Rossi, KA; Knabb, RM; Wexler, RR; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071941&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 15870101 103965640 CHEMBL329127 ZINC26648646 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50124263 NC(=N)c1cccc(c1)N1CCN(C2CCN(Cc3ccccc3)CC2)C1=O InChI=1S/C22H27N5O/c23-21(24)18-7-4-8-20(15-18)27-14-13-26(22(27)28)19-9-11-25(12-10-19)16-17-5-2-1-3-6-17/h1-8,15,19H,9-14,16H2,(H3,23,24) XZXIJUXYZNJQEP-UHFFFAOYSA-N 50071943 3-[3-(1-Benzyl-piperidin-4-yl)-2-oxo-imidazolidin-1-yl]-benzamidine::CHEMBL330125 Coagulation factor X Homo sapiens 2100 ChEMBL 10.1016/s0960-894x(98)00471-5 10.7270/Q23R0S13 9873607 Galemmo, RA; Maduskuie, TP; Dominguez, C; Rossi, KA; Knabb, RM; Wexler, RR; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071943&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 15870100 103965642 CHEMBL330125 ZINC26646930 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50124268 NC(=N)c1ccc(cc1)N1CCCCN(c2cccc(c2)C(N)=N)C1=O InChI=1S/C19H22N6O/c20-17(21)13-6-8-15(9-7-13)24-10-1-2-11-25(19(24)26)16-5-3-4-14(12-16)18(22)23/h3-9,12H,1-2,10-11H2,(H3,20,21)(H3,22,23) XPIYAMCDVRTICO-UHFFFAOYSA-N 50071946 3-(3-{4-[(Z)-amino(imino)methyl]phenyl}-2-oxo-1,3-diazepan-1-yl)benzenecarboximidamide::CHEMBL91654 Coagulation factor X Homo sapiens 800 ChEMBL 10.1016/s0960-894x(98)00471-5 10.7270/Q23R0S13 9873607 Galemmo, RA; Maduskuie, TP; Dominguez, C; Rossi, KA; Knabb, RM; Wexler, RR; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071946&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44324726 103965645 CHEMBL91654 ZINC26651371 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50124272 NC(=N)N1CCC(CC1)N1CCCCN(c2cccc(c2)C(N)=N)C1=O InChI=1S/C18H27N7O/c19-16(20)13-4-3-5-15(12-13)25-9-2-1-8-24(18(25)26)14-6-10-23(11-7-14)17(21)22/h3-5,12,14H,1-2,6-11H2,(H3,19,20)(H3,21,22) XSRYOJBWHVAMEX-UHFFFAOYSA-N 50071944 4-[3-(3-Carbamimidoyl-phenyl)-2-oxo-[1,3]diazepan-1-yl]-piperidine-1-carboxamidine::CHEMBL327814 Coagulation factor X Homo sapiens 2500 ChEMBL 10.1016/s0960-894x(98)00471-5 10.7270/Q23R0S13 9873607 Galemmo, RA; Maduskuie, TP; Dominguez, C; Rossi, KA; Knabb, RM; Wexler, RR; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071944&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44324745 103965643 CHEMBL327814 ZINC26654023 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50124275 NC(=N)c1ccc(cc1)N1CCCCN(C2CCN(Cc3ccccc3)CC2)C1=O InChI=1S/C24H31N5O/c25-23(26)20-8-10-21(11-9-20)28-14-4-5-15-29(24(28)30)22-12-16-27(17-13-22)18-19-6-2-1-3-7-19/h1-3,6-11,22H,4-5,12-18H2,(H3,25,26) PBKFFWDROFXKDQ-UHFFFAOYSA-N 50071947 4-[3-(1-Benzyl-piperidin-4-yl)-2-oxo-[1,3]diazepan-1-yl]-benzamidine::CHEMBL93480 Coagulation factor X Homo sapiens 7500 ChEMBL 10.1016/s0960-894x(98)00471-5 10.7270/Q23R0S13 9873607 Galemmo, RA; Maduskuie, TP; Dominguez, C; Rossi, KA; Knabb, RM; Wexler, RR; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071947&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44324744 103965646 CHEMBL93480 ZINC26653594 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50124276 NC(=N)c1cccc(c1)N1CCCCN(C2CCN(Cc3ccccc3)CC2)C1=O InChI=1S/C24H31N5O/c25-23(26)20-9-6-10-22(17-20)29-14-5-4-13-28(24(29)30)21-11-15-27(16-12-21)18-19-7-2-1-3-8-19/h1-3,6-10,17,21H,4-5,11-16,18H2,(H3,25,26) IVFAJJALDLLBIV-UHFFFAOYSA-N 50071942 3-[3-(1-Benzyl-piperidin-4-yl)-2-oxo-[1,3]diazepan-1-yl]-benzamidine::CHEMBL421370 Coagulation factor X Homo sapiens 102 ChEMBL 10.1016/s0960-894x(98)00471-5 10.7270/Q23R0S13 9873607 Galemmo, RA; Maduskuie, TP; Dominguez, C; Rossi, KA; Knabb, RM; Wexler, RR; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071942&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9887558 103965641 CHEMBL421370 ZINC26653598 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50124277 C\C(N)=[N+]1/CCC(C1)Oc1ccc(cc1)C(Cc1ccc2ccc(cc2c1)C(N)=[NH2+])C(O)=O InChI=1S/C26H28N4O3/c1-16(27)30-11-10-23(15-30)33-22-8-6-19(7-9-22)24(26(31)32)13-17-2-3-18-4-5-20(25(28)29)14-21(18)12-17/h2-9,12,14,23-24,27H,10-11,13,15H2,1H3,(H4,28,29,31,32)/p+2 FPCYYJGLPINSMR-UHFFFAOYSA-P 50071948 CHEMBL314535::Urea analogue Coagulation factor X Homo sapiens 30 ChEMBL 10.1016/s0960-894x(98)00471-5 10.7270/Q23R0S13 9873607 Galemmo, RA; Maduskuie, TP; Dominguez, C; Rossi, KA; Knabb, RM; Wexler, RR; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071948&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 78405027 103965647 CHEMBL314535 ZINC11686493 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50124281 NC(=N)c1cccc(NC(=O)NC2CCN(Cc3ccccc3)CC2)c1 InChI=1S/C20H25N5O/c21-19(22)16-7-4-8-18(13-16)24-20(26)23-17-9-11-25(12-10-17)14-15-5-2-1-3-6-15/h1-8,13,17H,9-12,14H2,(H3,21,22)(H2,23,24,26) QPPHMYQNDNAZMQ-UHFFFAOYSA-N 50071945 3-[3-(1-Benzyl-piperidin-4-yl)-ureido]-benzamidine::CHEMBL327254 Coagulation factor X Homo sapiens 4900 ChEMBL 10.1016/s0960-894x(98)00471-5 10.7270/Q23R0S13 9873607 Galemmo, RA; Maduskuie, TP; Dominguez, C; Rossi, KA; Knabb, RM; Wexler, RR; Stouten, PF DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071945&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44324727 103965644 CHEMBL327254 ZINC26651376 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50123326 CN(C)C(=O)c1cccc(Oc2nc(Oc3cc(ccc3O)C(N)=N)c(F)c(N(C)CC(O)=O)c2F)c1 InChI=1S/C24H23F2N5O6/c1-30(2)24(35)13-5-4-6-14(9-13)36-22-18(25)20(31(3)11-17(33)34)19(26)23(29-22)37-16-10-12(21(27)28)7-8-15(16)32/h4-10,32H,11H2,1-3H3,(H3,27,28)(H,33,34) SJXRMUMLUCMWJJ-UHFFFAOYSA-N 50066623 CHEMBL72318::{[2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-(3-dimethylcarbamoyl-phenoxy)-3,5-difluoro-pyridin-4-yl]-methyl-amino}-acetic acid Coagulation factor X Homo sapiens 0.410000 ChEMBL 10.1016/s0960-894x(98)00386-2 10.7270/Q2G44PGD 9873520 Buckman, BO; Mohan, R; Koovakkat, S; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066623&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10649512 103961243 CHEMBL72318 ZINC13781064 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50123327 CN(C)C(=O)c1cccc(Oc2nc3NCC(=O)Nc3c(Oc3cc(ccc3O)C(N)=N)n2)c1 InChI=1S/C22H21N7O5/c1-29(2)21(32)12-4-3-5-13(8-12)33-22-27-19-17(26-16(31)10-25-19)20(28-22)34-15-9-11(18(23)24)6-7-14(15)30/h3-9,30H,10H2,1-2H3,(H3,23,24)(H,26,31)(H,25,27,28) DOZWXXUWHDLZMJ-UHFFFAOYSA-N 50071417 3-[4-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-oxo-5,6,7,8-tetrahydro-pteridin-2-yloxy]-N,N-dimethyl-benzamide::CHEMBL71175 Coagulation factor X Homo sapiens 19 ChEMBL 10.1016/s0960-894x(98)00386-2 10.7270/Q2G44PGD 9873520 Buckman, BO; Mohan, R; Koovakkat, S; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071417&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22103167 103965170 CHEMBL71175 ZINC01545942 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50123328 CN(C)C(=O)c1cccc(Oc2nc(Oc3cc(ccc3O)C(N)=N)nc3NCC(=O)Nc23)c1 InChI=1S/C22H21N7O5/c1-29(2)21(32)12-4-3-5-13(8-12)33-20-17-19(25-10-16(31)26-17)27-22(28-20)34-15-9-11(18(23)24)6-7-14(15)30/h3-9,30H,10H2,1-2H3,(H3,23,24)(H,26,31)(H,25,27,28) PILHGSGBSPLDRI-UHFFFAOYSA-N 50071418 3-[2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-oxo-5,6,7,8-tetrahydro-pteridin-4-yloxy]-N,N-dimethyl-benzamide::CHEMBL307989 Coagulation factor X Homo sapiens 81 ChEMBL 10.1016/s0960-894x(98)00386-2 10.7270/Q2G44PGD 9873520 Buckman, BO; Mohan, R; Koovakkat, S; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071418&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22102799 103965171 CHEMBL307989 ZINC01545941 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50123334 NC(=N)c1ccc(\C=C2\CCCC\C(=C\c3ccc(cc3)C(N)=N)C2=O)cc1 InChI=1S/C23H24N4O/c24-22(25)17-9-5-15(6-10-17)13-19-3-1-2-4-20(21(19)28)14-16-7-11-18(12-8-16)23(26)27/h5-14H,1-4H2,(H3,24,25)(H3,26,27)/b19-13-,20-14- BGRKMKHJBDYTGS-AXPXABNXSA-N 17277 (Z,Z)BABCH::4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl)methylidene]-2-oxocycloheptylidene]methyl}benzene-1-carboximidamide::CHEMBL55035 Coagulation factor X Homo sapiens 0.660000 ChEMBL 10.1016/s0960-894x(98)00386-2 10.7270/Q2G44PGD 9873520 Buckman, BO; Mohan, R; Koovakkat, S; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17277&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1A5H,1V2N 10361934 46517455 CHEMBL55035 ZINC01545718 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50123336 CN(C)C(=O)c1cccc(Oc2nc(Oc3cc(ccc3O)C(N)=N)nc3n(Cc4ccccc4)c(C)nc23)c1 InChI=1S/C29H27N7O4/c1-17-32-24-26(36(17)16-18-8-5-4-6-9-18)33-29(40-23-15-19(25(30)31)12-13-22(23)37)34-27(24)39-21-11-7-10-20(14-21)28(38)35(2)3/h4-15,37H,16H2,1-3H3,(H3,30,31) XWONPVXAQKMKDM-UHFFFAOYSA-N 50071419 3-[9-Benzyl-2-(5-carbamimidoyl-2-hydroxy-phenoxy)-8-methyl-9H-purin-6-yloxy]-N,N-dimethyl-benzamide::CHEMBL72527 Coagulation factor X Homo sapiens 10 ChEMBL 10.1016/s0960-894x(98)00386-2 10.7270/Q2G44PGD 9873520 Buckman, BO; Mohan, R; Koovakkat, S; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071419&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 18916756 103965172 CHEMBL72527 ZINC01903301 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50123337 CN(C)C(=O)c1cccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)c(C)c2F)c1 InChI=1S/C22H20F2N4O3/c1-12-17(23)20(30-15-8-4-6-13(10-15)19(25)26)27-21(18(12)24)31-16-9-5-7-14(11-16)22(29)28(2)3/h4-11H,1-3H3,(H3,25,26) WBQTWIMCPJDTPA-UHFFFAOYSA-N 50066633 3-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-N,N-dimethyl-benzamide::CHEMBL70730 Coagulation factor X Homo sapiens 80 ChEMBL 10.1016/s0960-894x(98)00386-2 10.7270/Q2G44PGD 9873520 Buckman, BO; Mohan, R; Koovakkat, S; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066633&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11743193 103961253 CHEMBL70730 ZINC13473988 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50123342 CN(C)C(=O)c1cccc(Oc2nc(Oc3cc(ccc3O)C(N)=N)c3nc(C)n(Cc4ccccc4)c3n2)c1 InChI=1S/C29H27N7O4/c1-17-32-24-26(36(17)16-18-8-5-4-6-9-18)33-29(39-21-11-7-10-20(14-21)28(38)35(2)3)34-27(24)40-23-15-19(25(30)31)12-13-22(23)37/h4-15,37H,16H2,1-3H3,(H3,30,31) IKOPFZLRBYCQSH-UHFFFAOYSA-N 50071415 3-[9-Benzyl-6-(5-carbamimidoyl-2-hydroxy-phenoxy)-8-methyl-9H-purin-2-yloxy]-N,N-dimethyl-benzamide::CHEMBL305809 Coagulation factor X Homo sapiens 0.420000 ChEMBL 10.1016/s0960-894x(98)00386-2 10.7270/Q2G44PGD 9873520 Buckman, BO; Mohan, R; Koovakkat, S; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071415&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10414843 103965168 CHEMBL305809 ZINC26376265 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50123344 CN(C)C(=O)c1cccc(Oc2nc(Oc3cc(ccc3O)C(N)=N)nc3OCC(=O)Nc23)c1 InChI=1S/C22H20N6O6/c1-28(2)21(31)12-4-3-5-13(8-12)33-20-17-19(32-10-16(30)25-17)26-22(27-20)34-15-9-11(18(23)24)6-7-14(15)29/h3-9,29H,10H2,1-2H3,(H3,23,24)(H,25,30) CGKDNHKMKYUGJQ-UHFFFAOYSA-N 50071416 3-[2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-oxo-6,7-dihydro-5H-pyrimido[4,5-b][1,4]oxazin-4-yloxy]-N,N-dimethyl-benzamide::CHEMBL71975 Coagulation factor X Homo sapiens 106 ChEMBL 10.1016/s0960-894x(98)00386-2 10.7270/Q2G44PGD 9873520 Buckman, BO; Mohan, R; Koovakkat, S; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071416&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10027433 103965169 CHEMBL71975 ZINC26288292 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50123347 CN(CC(O)=O)c1c(F)c(Oc2cccc(c2)C2=NCCN2C)nc(Oc2cc(ccc2O)C(N)=N)c1F InChI=1S/C25H24F2N6O5/c1-32-9-8-30-23(32)14-4-3-5-15(10-14)37-24-19(26)21(33(2)12-18(35)36)20(27)25(31-24)38-17-11-13(22(28)29)6-7-16(17)34/h3-7,10-11,34H,8-9,12H2,1-2H3,(H3,28,29)(H,35,36) NPNSVNGQJGRSNR-UHFFFAOYSA-N 17284 2-{[2-(5-carbamimidoyl-2-hydroxyphenoxy)-3,5-difluoro-6-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridin-4-yl](methyl)amino}acetic acid::CHEMBL73193::CI-1031::ZK-807834 Coagulation factor X Homo sapiens 0.110000 ChEMBL 10.1016/s0960-894x(98)00386-2 10.7270/Q2G44PGD 9873520 Buckman, BO; Mohan, R; Koovakkat, S; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17284&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search Z34 1FJS 5353802 46517462 CHEMBL73193 ZINC01902827 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122541 NC(=N)c1ccc(\C=C2\CCCC\C(=C\c3ccc(cc3)C(N)=N)C2=O)cc1 InChI=1S/C23H24N4O/c24-22(25)17-9-5-15(6-10-17)13-19-3-1-2-4-20(21(19)28)14-16-7-11-18(12-8-16)23(26)27/h5-14H,1-4H2,(H3,24,25)(H3,26,27)/b19-13-,20-14- BGRKMKHJBDYTGS-AXPXABNXSA-N 17277 (Z,Z)BABCH::4-{[(1Z,3Z)-3-[(4-carbamimidoylphenyl)methylidene]-2-oxocycloheptylidene]methyl}benzene-1-carboximidamide::CHEMBL55035 Coagulation factor X Homo sapiens 13 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17277&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1A5H,1V2N 10361934 46517455 CHEMBL55035 ZINC01545718 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122542 Cc1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2cccc(c2)C(N)=N)c1F InChI=1S/C20H17F2N5O2/c1-10-15(21)19(28-13-6-2-4-11(8-13)17(23)24)27-20(16(10)22)29-14-7-3-5-12(9-14)18(25)26/h2-9H,1H3,(H3,23,24)(H3,25,26) ZXIHYCYAQUQHSG-UHFFFAOYSA-N 17278 3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-methylpyridin-2-yl]oxy}benzene-1-carboximidamide::CHEMBL49636::Pyridine template, III::ZK-805623 Coagulation factor X Homo sapiens 13 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17278&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1QB6 448061 46517456 CHEMBL49636 ZINC00585999 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122543 Cc1c(F)c(Oc2cccc(c2)C(N)=N)nc(N2CCN(CC2)c2ccc3OCOc3c2)c1F InChI=1S/C24H23F2N5O3/c1-14-20(25)23(29-24(21(14)26)34-17-4-2-3-15(11-17)22(27)28)31-9-7-30(8-10-31)16-5-6-18-19(12-16)33-13-32-18/h2-6,11-12H,7-10,13H2,1H3,(H3,27,28) FVQANJGIHHWEOI-UHFFFAOYSA-N 50071039 3-[6-(4-Benzo[1,3]dioxol-5-yl-piperazin-1-yl)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-benzamidine::CHEMBL55828 Coagulation factor X Homo sapiens >5000 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071039&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44298971 103964832 CHEMBL55828 ZINC29552068 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122544 Cc1c(F)c(OC2CCNC2)nc(Oc2cccc(c2)C(N)=N)c1F InChI=1S/C17H18F2N4O2/c1-9-13(18)16(24-11-4-2-3-10(7-11)15(20)21)23-17(14(9)19)25-12-5-6-22-8-12/h2-4,7,12,22H,5-6,8H2,1H3,(H3,20,21) MEJCGHQYEAPYAI-UHFFFAOYSA-N 50071040 3-[3,5-Difluoro-4-methyl-6-(pyrrolidin-3-yloxy)-pyridin-2-yloxy]-benzamidine::CHEMBL54676 Coagulation factor X Homo sapiens >5000 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071040&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44298298 103964833 CHEMBL54676 ZINC29546923 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122545 Cc1c(F)c(Oc2cccc(c2)C(N)=N)nc(N2CCN(CC2)C2CCCCC2)c1F InChI=1S/C23H29F2N5O/c1-15-19(24)22(30-12-10-29(11-13-30)17-7-3-2-4-8-17)28-23(20(15)25)31-18-9-5-6-16(14-18)21(26)27/h5-6,9,14,17H,2-4,7-8,10-13H2,1H3,(H3,26,27) YEYGQZHCFUOWLX-UHFFFAOYSA-N 50071041 3-[6-(4-Cyclohexyl-piperazin-1-yl)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-benzamidine::CHEMBL56410 Coagulation factor X Homo sapiens 495 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071041&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11743369 103964834 CHEMBL56410 ZINC29555122 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122546 Cc1c(F)c(Oc2cccc(c2)C(N)=N)nc(N2CCC[C@H]2CO)c1F InChI=1S/C18H20F2N4O2/c1-10-14(19)17(24-7-3-5-12(24)9-25)23-18(15(10)20)26-13-6-2-4-11(8-13)16(21)22/h2,4,6,8,12,25H,3,5,7,9H2,1H3,(H3,21,22)/t12-/m0/s1 UEFJGRKEWUEXHA-LBPRGKRZSA-N 50071042 3-[3,5-Difluoro-6-((S)-2-hydroxymethyl-pyrrolidin-1-yl)-4-methyl-pyridin-2-yloxy]-benzamidine::CHEMBL55575 Coagulation factor X Homo sapiens >5000 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071042&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44298972 103964835 CHEMBL55575 ZINC29552072 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122547 CCCOCCNc1nc(Oc2cccc(c2)C(N)=N)c(F)c(C)c1F InChI=1S/C18H22F2N4O2/c1-3-8-25-9-7-23-17-14(19)11(2)15(20)18(24-17)26-13-6-4-5-12(10-13)16(21)22/h4-6,10H,3,7-9H2,1-2H3,(H3,21,22)(H,23,24) RKXWESJUZGMHJQ-UHFFFAOYSA-N 50071043 3-[3,5-Difluoro-4-methyl-6-(2-propoxy-ethylamino)-pyridin-2-yloxy]-benzamidine::CHEMBL54672 Coagulation factor X Homo sapiens >5000 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071043&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44298941 103964836 CHEMBL54672 ZINC29489606 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122548 Cc1c(F)c(NCCCN2CCCC2=O)nc(Oc2cccc(c2)C(N)=N)c1F InChI=1S/C20H23F2N5O2/c1-12-16(21)19(25-8-4-10-27-9-3-7-15(27)28)26-20(17(12)22)29-14-6-2-5-13(11-14)18(23)24/h2,5-6,11H,3-4,7-10H2,1H3,(H3,23,24)(H,25,26) RWUDPDMMTUNSRU-UHFFFAOYSA-N 50071045 3-{3,5-Difluoro-4-methyl-6-[3-(2-oxo-pyrrolidin-1-yl)-propylamino]-pyridin-2-yloxy}-benzamidine::CHEMBL301057 Coagulation factor X Homo sapiens >5000 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071045&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44299040 103964838 CHEMBL301057 ZINC29547530 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122549 NC(=N)c1ccccc1 InChI=1S/C7H8N2/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H3,8,9) PXXJHWLDUBFPOL-UHFFFAOYSA-N 50038002 Benzamidine (Protonated)::CHEMBL20936::CHEMBL537204::benzamidine Coagulation factor X Homo sapiens 410 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038002&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search BDN 2332 103945453 41033 CHEMBL20936CHEMBL537204 C01784 ZINC00036634 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122550 Cc1cccc(C)c1N1CCN(CC1)c1nc(Oc2cccc(c2)C(N)=N)c(F)c(C)c1F InChI=1S/C25H27F2N5O/c1-15-6-4-7-16(2)22(15)31-10-12-32(13-11-31)24-20(26)17(3)21(27)25(30-24)33-19-9-5-8-18(14-19)23(28)29/h4-9,14H,10-13H2,1-3H3,(H3,28,29) NEIZOKBCYFXBKJ-UHFFFAOYSA-N 50071044 3-{6-[4-(2,6-Dimethyl-phenyl)-piperazin-1-yl]-3,5-difluoro-4-methyl-pyridin-2-yloxy}-benzamidine::CHEMBL300796 Coagulation factor X Homo sapiens >5000 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071044&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44298563 103964837 CHEMBL300796 ZINC29549476 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122551 CN1CCN(CC1)c1nc(Oc2cccc(c2)C(N)=N)c(F)c(C)c1F InChI=1S/C18H21F2N5O/c1-11-14(19)17(25-8-6-24(2)7-9-25)23-18(15(11)20)26-13-5-3-4-12(10-13)16(21)22/h3-5,10H,6-9H2,1-2H3,(H3,21,22) JFABBKYOADGDSS-UHFFFAOYSA-N 50071047 3-[3,5-Difluoro-4-methyl-6-(4-methyl-piperazin-1-yl)-pyridin-2-yloxy]-benzamidine::CHEMBL55766 Coagulation factor X Homo sapiens >5000 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071047&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44298559 103964840 CHEMBL55766 ZINC29547607 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122552 CCOC(=O)C1CCCN(C1)c1nc(Oc2cccc(c2)C(N)=N)c(F)c(C)c1F InChI=1S/C21H24F2N4O3/c1-3-29-21(28)14-7-5-9-27(11-14)19-16(22)12(2)17(23)20(26-19)30-15-8-4-6-13(10-15)18(24)25/h4,6,8,10,14H,3,5,7,9,11H2,1-2H3,(H3,24,25) FHPCCRAETPUFNV-UHFFFAOYSA-N 50071046 6'-(3-Carbamimidoyl-phenoxy)-3',5'-difluoro-4'-methyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3-carboxylic acid ethyl ester::CHEMBL293108 Coagulation factor X Homo sapiens >5000 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071046&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44298594 103964839 CHEMBL293108 ZINC29549783 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122553 Cc1c(F)c(Oc2cccc(c2)C(N)=N)nc(N2CCN(CC2)c2ccco2)c1F InChI=1S/C21H21F2N5O2/c1-13-17(22)20(28-9-7-27(8-10-28)16-6-3-11-29-16)26-21(18(13)23)30-15-5-2-4-14(12-15)19(24)25/h2-6,11-12H,7-10H2,1H3,(H3,24,25) FHRKDBKFCJZHHR-UHFFFAOYSA-N 50071048 3-[3,5-Difluoro-6-(4-furan-2-yl-piperazin-1-yl)-4-methyl-pyridin-2-yloxy]-benzamidine::CHEMBL292203 Coagulation factor X Homo sapiens >5000 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071048&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44298587 103964841 CHEMBL292203 ZINC29545704 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122554 Cc1c(F)c(Oc2cccc(c2)C(N)=N)nc(N2CCC(C)(CC2)c2ccccc2)c1F InChI=1S/C25H26F2N4O/c1-16-20(26)23(31-13-11-25(2,12-14-31)18-8-4-3-5-9-18)30-24(21(16)27)32-19-10-6-7-17(15-19)22(28)29/h3-10,15H,11-14H2,1-2H3,(H3,28,29) QGIPJVHEMNUPHU-UHFFFAOYSA-N 50071051 3-(3',5'-Difluoro-4,4'-dimethyl-4-phenyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-6'-yloxy)-benzamidine::CHEMBL417750 Coagulation factor X Homo sapiens 560 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071051&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10478176 103964844 CHEMBL417750 ZINC29551234 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122555 Cc1c(F)c(Oc2cccc(c2)C(N)=N)nc(N2CCN(CC(=O)N3CCOCC3)CC2)c1F InChI=1S/C23H28F2N6O3/c1-15-19(24)22(28-23(20(15)25)34-17-4-2-3-16(13-17)21(26)27)31-7-5-29(6-8-31)14-18(32)30-9-11-33-12-10-30/h2-4,13H,5-12,14H2,1H3,(H3,26,27) MGPQKMLCRPUMJG-UHFFFAOYSA-N 50071053 3-{3,5-Difluoro-4-methyl-6-[4-(2-morpholin-4-yl-2-oxo-ethyl)-piperazin-1-yl]-pyridin-2-yloxy}-benzamidine::CHEMBL442554 Coagulation factor X Homo sapiens >5000 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071053&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44298595 103964846 CHEMBL442554 ZINC29548808 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122556 Cc1c(F)c(NC2CCCCC2)nc(Oc2cccc(c2)C(N)=N)c1F InChI=1S/C19H22F2N4O/c1-11-15(20)18(24-13-7-3-2-4-8-13)25-19(16(11)21)26-14-9-5-6-12(10-14)17(22)23/h5-6,9-10,13H,2-4,7-8H2,1H3,(H3,22,23)(H,24,25) CRLDQPGUVSIDBC-UHFFFAOYSA-N 50071049 3-(6-Cyclohexylamino-3,5-difluoro-4-methyl-pyridin-2-yloxy)-benzamidine::CHEMBL54615 Coagulation factor X Homo sapiens >5000 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071049&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44298940 103964842 CHEMBL54615 ZINC29489604 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122557 NC(=N)c1cccc(COc2ccccc2)c1 InChI=1S/C14H14N2O/c15-14(16)12-6-4-5-11(9-12)10-17-13-7-2-1-3-8-13/h1-9H,10H2,(H3,15,16) RZNBPLWRIVTCIZ-UHFFFAOYSA-N 50071050 3-amidinobenzyl phenyl ether::CHEMBL294703 Coagulation factor X Homo sapiens 6.8 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071050&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 12222233 103964843 CHEMBL294703 ZINC19479622 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122558 CN(C)CCNc1nc(Oc2cccc(c2)C(N)=N)c(F)c(C)c1F InChI=1S/C17H21F2N5O/c1-10-13(18)16(22-7-8-24(2)3)23-17(14(10)19)25-12-6-4-5-11(9-12)15(20)21/h4-6,9H,7-8H2,1-3H3,(H3,20,21)(H,22,23) OLRYMYFTAHTBMZ-UHFFFAOYSA-N 50071054 3-[6-(2-Dimethylamino-ethylamino)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-benzamidine::CHEMBL55855 Coagulation factor X Homo sapiens >5000 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071054&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44298564 103964847 CHEMBL55855 ZINC29549480 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50122559 CC(=N)N1CCC(C1)Oc1nc(Oc2cccc(c2)C(N)=N)c(F)c(C)c1F InChI=1S/C19H21F2N5O2/c1-10-15(20)18(27-13-5-3-4-12(8-13)17(23)24)25-19(16(10)21)28-14-6-7-26(9-14)11(2)22/h3-5,8,14,22H,6-7,9H2,1-2H3,(H3,23,24) KTJRHEDUTSBJEQ-UHFFFAOYSA-N 50071052 3-{3,5-Difluoro-6-[1-(1-imino-ethyl)-pyrrolidin-3-yloxy]-4-methyl-pyridin-2-yloxy}-benzamidine::CHEMBL433274 Coagulation factor X Homo sapiens >5000 ChEMBL 10.1016/s0960-894x(98)00333-3 10.7270/Q2222SX9 9873451 Mohan, R; Yun, W; Buckman, BO; Liang, A; Trinh, L; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071052&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44298541 103964845 CHEMBL433274 ZINC29485231 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50123796 NC(=N)N1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O InChI=1S/C20H30N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-3,6-7,15-16,19,24,29H,4-5,8-13H2,(H3,21,22)(H,23,27)/t15-,16-,19?/m0/s1 SPUAEQJRVQHWKF-NRAVZPKASA-N 50071693 CHEMBL38927::CVS-1578::N-((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-acetamide::N-(1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-(2-oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-acetamide Coagulation factor X Homo sapiens 2500 ChEMBL 10.1016/s0960-894x(98)00448-x 10.7270/Q28C9VCK 9873569 Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071693&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9869156 103965403 CHEMBL38927 ZINC28005318 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50123797 CCOC(=O)[C@@]1(CCCN(CC(=O)N[C@H]2CCCN([C@@H]2O)C(N)=N)C1=O)NS(=O)(=O)Cc1ccccc1 InChI=1S/C23H34N6O7S/c1-2-36-21(33)23(27-37(34,35)15-16-8-4-3-5-9-16)11-7-12-28(20(23)32)14-18(30)26-17-10-6-13-29(19(17)31)22(24)25/h3-5,8-9,17,19,27,31H,2,6-7,10-15H2,1H3,(H3,24,25)(H,26,30)/t17-,19+,23-/m0/s1 YLPFNSPUPARBLY-GWJPWWOOSA-N 50071695 (S)-1-[((2R,3S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-3-phenylmethanesulfonylamino-piperidine-3-carboxylic acid ethyl ester::CHEMBL85282 Coagulation factor X Homo sapiens 5.8 ChEMBL 10.1016/s0960-894x(98)00448-x 10.7270/Q28C9VCK 9873569 Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071695&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44318182 103965405 CHEMBL85282 ZINC26569554 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50123809 CCOC(=O)[C@@]1(CCCN(CC(=O)N[C@H]2CCCN([C@H]2O)C(N)=N)C1=O)NS(=O)(=O)Cc1ccccc1 InChI=1S/C23H34N6O7S/c1-2-36-21(33)23(27-37(34,35)15-16-8-4-3-5-9-16)11-7-12-28(20(23)32)14-18(30)26-17-10-6-13-29(19(17)31)22(24)25/h3-5,8-9,17,19,27,31H,2,6-7,10-15H2,1H3,(H3,24,25)(H,26,30)/t17-,19-,23-/m0/s1 YLPFNSPUPARBLY-LTMIRXACSA-N 50071696 (S)-1-[((2S,3S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-3-phenylmethanesulfonylamino-piperidine-3-carboxylic acid ethyl ester::CHEMBL421136 Coagulation factor X Homo sapiens 43 ChEMBL 10.1016/s0960-894x(98)00448-x 10.7270/Q28C9VCK 9873569 Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071696&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44462312 103965406 CHEMBL421136 ZINC26500062 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50126972 NC(=N)N1CCC[C@H](NC(=O)CN2CCCC[C@H](NS(=O)(=O)Cc3ccccc3C(O)=O)C2=O)C1O InChI=1S/C22H32N6O7S/c23-22(24)28-11-5-9-16(20(28)31)25-18(29)12-27-10-4-3-8-17(19(27)30)26-36(34,35)13-14-6-1-2-7-15(14)21(32)33/h1-2,6-7,16-17,20,26,31H,3-5,8-13H2,(H3,23,24)(H,25,29)(H,32,33)/t16-,17-,20?/m0/s1 PSLDGXDWGVAQGZ-NBJLRHFZSA-N 50073428 2-({(S)-1-[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-azepan-3-ylsulfamoyl}-methyl)-benzoic acid; TFA::CHEMBL122435 Coagulation factor X Homo sapiens >2500 ChEMBL 10.1016/s0960-894x(98)00667-2 10.7270/Q2ZP459T 9934495 Owens, TD; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073428&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44347559 103966822 CHEMBL122435 ZINC27205077 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50126977 CCCOC(=O)c1ccccc1CS(=O)(=O)N[C@H]1CCCCN(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)C1=O InChI=1S/C25H38N6O7S/c1-2-14-38-24(35)18-9-4-3-8-17(18)16-39(36,37)29-20-10-5-6-12-30(22(20)33)15-21(32)28-19-11-7-13-31(23(19)34)25(26)27/h3-4,8-9,19-20,23,29,34H,2,5-7,10-16H2,1H3,(H3,26,27)(H,28,32)/t19-,20-,23?/m0/s1 WVANINVYBRHJAG-ZXTYOHMPSA-N 50073431 2-({(S)-1-[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-azepan-3-ylsulfamoyl}-methyl)-benzoic acid propyl ester; TFA::CHEMBL122920 Coagulation factor X Homo sapiens 451.0 ChEMBL 10.1016/s0960-894x(98)00667-2 10.7270/Q2ZP459T 9934495 Owens, TD; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073431&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44347493 103966825 CHEMBL122920 ZINC27200466 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50126980 CCCCCCCCCCOC(=O)c1ccccc1CS(=O)(=O)N[C@H]1CCCCN(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)C1=O InChI=1S/C32H52N6O7S/c1-2-3-4-5-6-7-8-13-21-45-31(42)25-16-10-9-15-24(25)23-46(43,44)36-27-17-11-12-19-37(29(27)40)22-28(39)35-26-18-14-20-38(30(26)41)32(33)34/h9-10,15-16,26-27,30,36,41H,2-8,11-14,17-23H2,1H3,(H3,33,34)(H,35,39)/t26-,27-,30?/m0/s1 DIADOEUKGBTXJB-WPVVHWIUSA-N 50073425 2-({(S)-1-[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-azepan-3-ylsulfamoyl}-methyl)-benzoic acid decyl ester; TFA::CHEMBL122170 Coagulation factor X Homo sapiens >2500 ChEMBL 10.1016/s0960-894x(98)00667-2 10.7270/Q2ZP459T 9934495 Owens, TD; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073425&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44347561 103966819 CHEMBL122170 ZINC49877903 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50126981 COC(=O)c1ccccc1CS(=O)(=O)N[C@H]1CCCCN(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)C1=O InChI=1S/C23H34N6O7S/c1-36-22(33)16-8-3-2-7-15(16)14-37(34,35)27-18-9-4-5-11-28(20(18)31)13-19(30)26-17-10-6-12-29(21(17)32)23(24)25/h2-3,7-8,17-18,21,27,32H,4-6,9-14H2,1H3,(H3,24,25)(H,26,30)/t17-,18-,21?/m0/s1 CSNUWINOCPJKME-GAOSQQNJSA-N 50073426 2-({(S)-1-[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-azepan-3-ylsulfamoyl}-methyl)-benzoic acid methyl ester; TFA::CHEMBL125988 Coagulation factor X Homo sapiens 333 ChEMBL 10.1016/s0960-894x(98)00667-2 10.7270/Q2ZP459T 9934495 Owens, TD; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073426&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10673965 103966820 CHEMBL125988 ZINC27205950 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50126986 NC(=N)N1CCC[C@H](NC(=O)CN2CCCC[C@H](N3C(=O)c4ccccc4CS3(=O)=O)C2=O)C1O InChI=1S/C22H30N6O6S/c23-22(24)27-11-5-8-16(20(27)31)25-18(29)12-26-10-4-3-9-17(21(26)32)28-19(30)15-7-2-1-6-14(15)13-35(28,33)34/h1-2,6-7,16-17,20,31H,3-5,8-13H2,(H3,23,24)(H,25,29)/t16-,17-,20?/m0/s1 UMNHQMCBYLHVMV-NBJLRHFZSA-N 50073427 CHEMBL331909::N-((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-[(S)-2-oxo-3-(2,2,4-trioxo-1,4-dihydro-2H-2lambda*6*-benzo[d][1,2]thiazin-3-yl)-azepan-1-yl]-acetamide; TFA Coagulation factor X Homo sapiens >2500 ChEMBL 10.1016/s0960-894x(98)00667-2 10.7270/Q2ZP459T 9934495 Owens, TD; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073427&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44347491 103966821 CHEMBL331909 ZINC27201797 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50126987 NC(=N)N1CCC[C@H](NC(=O)CN2CCCC[C@H](NS(=O)(=O)Cc3ccccc3C(=O)OCC3CCCCC3)C2=O)C1O InChI=1S/C29H44N6O7S/c30-29(31)35-16-8-14-23(27(35)38)32-25(36)17-34-15-7-6-13-24(26(34)37)33-43(40,41)19-21-11-4-5-12-22(21)28(39)42-18-20-9-2-1-3-10-20/h4-5,11-12,20,23-24,27,33,38H,1-3,6-10,13-19H2,(H3,30,31)(H,32,36)/t23-,24-,27?/m0/s1 RAZWOVWZXQATMU-HFKGTQBBSA-N 50073432 2-({(S)-1-[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-azepan-3-ylsulfamoyl}-methyl)-benzoic acid cyclohexylmethyl ester; TFA::CHEMBL123342 Coagulation factor X Homo sapiens 627 ChEMBL 10.1016/s0960-894x(98)00667-2 10.7270/Q2ZP459T 9934495 Owens, TD; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073432&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44347532 103966826 CHEMBL123342 ZINC27196619 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50126988 NC(=N)N1CCC[C@H](NC(=O)CN2CCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O InChI=1S/C20H30N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-3,6-7,15-16,19,24,29H,4-5,8-13H2,(H3,21,22)(H,23,27)/t15-,16-,19?/m0/s1 SPUAEQJRVQHWKF-NRAVZPKASA-N 50071693 CHEMBL38927::CVS-1578::N-((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-acetamide::N-(1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-(2-oxo-3-phenylmethanesulfonylamino-piperidin-1-yl)-acetamide Coagulation factor X Homo sapiens >2500 ChEMBL 10.1016/s0960-894x(98)00667-2 10.7270/Q2ZP459T 9934495 Owens, TD; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071693&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9869156 103965403 CHEMBL38927 ZINC28005318 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50126991 CC(C)OC(=O)c1ccccc1CS(=O)(=O)N[C@H]1CCCCN(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)C1=O InChI=1S/C25H38N6O7S/c1-16(2)38-24(35)18-9-4-3-8-17(18)15-39(36,37)29-20-10-5-6-12-30(22(20)33)14-21(32)28-19-11-7-13-31(23(19)34)25(26)27/h3-4,8-9,16,19-20,23,29,34H,5-7,10-15H2,1-2H3,(H3,26,27)(H,28,32)/t19-,20-,23?/m0/s1 HBXGGCPENRAIDU-ZXTYOHMPSA-N 50073430 2-({(S)-1-[((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-ylcarbamoyl)-methyl]-2-oxo-azepan-3-ylsulfamoyl}-methyl)-benzoic acid isopropyl ester; TFA::CHEMBL332537 Coagulation factor X Homo sapiens 369 ChEMBL 10.1016/s0960-894x(98)00667-2 10.7270/Q2ZP459T 9934495 Owens, TD; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073430&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44347498 103966824 CHEMBL332537 ZINC27194648 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50126992 NC(=N)N1CCC[C@H](NC(=O)CN2CCCC[C@H](NS(=O)(=O)Cc3ccccc3)C2=O)C1O InChI=1S/C21H32N6O5S/c22-21(23)27-12-6-10-16(20(27)30)24-18(28)13-26-11-5-4-9-17(19(26)29)25-33(31,32)14-15-7-2-1-3-8-15/h1-3,7-8,16-17,20,25,30H,4-6,9-14H2,(H3,22,23)(H,24,28)/t16-,17-,20?/m0/s1 PIIUKKBKYNGKMK-NBJLRHFZSA-N 50073429 CHEMBL82032::CHEMBL84575::N-((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide Coagulation factor X Homo sapiens 40 ChEMBL 10.1016/s0960-894x(98)00667-2 10.7270/Q2ZP459T 9934495 Owens, TD; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073429&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9913055 103966823 CHEMBL82032CHEMBL84575 ZINC13760101 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134640 NC(=N)c1cccc(Oc2cccc(Oc3cccc(c3)C(N)=N)n2)c1 InChI=1S/C19H17N5O2/c20-18(21)12-4-1-6-14(10-12)25-16-8-3-9-17(24-16)26-15-7-2-5-13(11-15)19(22)23/h1-11H,(H3,20,21)(H3,22,23) WNTHPCMKWFKFIU-UHFFFAOYSA-N 50066626 3-{6-[3-amino(imino)methylphenoxy]-2-pyridyloxy}phenyl-iminomethanamine::CHEMBL50127 Coagulation factor X Homo sapiens 53 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066626&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10831506 103961246 CHEMBL50127 ZINC13781059 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134643 NC(=N)c1cccc(Oc2cc(Oc3ccccc3C(N)=N)ccc2[N+]([O-])=O)c1 InChI=1S/C20H17N5O4/c21-19(22)12-4-3-5-13(10-12)29-18-11-14(8-9-16(18)25(26)27)28-17-7-2-1-6-15(17)20(23)24/h1-11H,(H3,21,22)(H3,23,24) RISPNJCORRYQND-UHFFFAOYSA-N 50077182 2-{3-[3-amino(imino)methylphenoxy]-4-nitrophenoxy}phenyl-iminomethanamine::CHEMBL50972 Coagulation factor X Homo sapiens 300 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077182&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44294201 103969990 CHEMBL50972 ZINC29471500 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134644 NC(=O)CNC(=O)Nc1ccc(Oc2cccc(c2)C(N)=N)nc1Oc1cccc(c1)C(N)=N InChI=1S/C22H22N8O4/c23-17(31)11-28-22(32)29-16-7-8-18(33-14-5-1-3-12(9-14)19(24)25)30-21(16)34-15-6-2-4-13(10-15)20(26)27/h1-10H,11H2,(H2,23,31)(H3,24,25)(H3,26,27)(H2,28,29,32) UIKDJAHXHVUPPY-UHFFFAOYSA-N 50077167 2-{3-[2,6-Bis-(3-carbamimidoyl-phenoxy)-pyridin-3-yl]-ureido}-acetamide::CHEMBL296618 Coagulation factor X Homo sapiens 110 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077167&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10576002 103969975 CHEMBL296618 ZINC13797412 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134646 Cc1c(F)c(Nc2cccc(c2)C(N)=N)nc(Oc2cccc(c2)C(N)=N)c1F InChI=1S/C20H18F2N6O/c1-10-15(21)19(27-13-6-2-4-11(8-13)17(23)24)28-20(16(10)22)29-14-7-3-5-12(9-14)18(25)26/h2-9H,1H3,(H3,23,24)(H3,25,26)(H,27,28) WFNZWAUCNYWALG-UHFFFAOYSA-N 50077166 2N-[3-amino(imino)methylphenyl]-6-[3-amino(imino)methylphenoxy]-3,5-difluoro-4-methyl-2-pyridinamine::CHEMBL50909 Coagulation factor X Homo sapiens 660 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077166&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10668443 103969974 CHEMBL50909 ZINC13797456 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134648 NC(=N)c1ccc(Oc2cccc(Oc3ccc(cc3)C(N)=N)c2)cc1 InChI=1S/C20H18N4O2/c21-19(22)13-4-8-15(9-5-13)25-17-2-1-3-18(12-17)26-16-10-6-14(7-11-16)20(23)24/h1-12H,(H3,21,22)(H3,23,24) XWYDBEAPGXZEHX-UHFFFAOYSA-N 50077177 4-{3-[4-amino(imino)methylphenoxy]phenoxy}phenyl-iminomethanamine::CHEMBL48199 Coagulation factor X Homo sapiens 970 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077177&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10315612 103969985 CHEMBL48199 ZINC12354909 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134651 CNC(=O)c1cc(Oc2cccc(c2)C(N)=N)nc(Oc2cccc(c2)C(N)=N)c1 InChI=1S/C21H20N6O3/c1-26-21(28)14-10-17(29-15-6-2-4-12(8-15)19(22)23)27-18(11-14)30-16-7-3-5-13(9-16)20(24)25/h2-11H,1H3,(H3,22,23)(H3,24,25)(H,26,28) LXBBMGAPPDOCAP-UHFFFAOYSA-N 50077180 2,6-Bis-(3-carbamimidoyl-phenoxy)-N-methyl-isonicotinamide::CHEMBL48409 Coagulation factor X Homo sapiens 60 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077180&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10692579 103969988 CHEMBL48409 ZINC13797439 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134652 NC(=N)c1cccc(Oc2cncc(Oc3cccc(n3)C(N)=N)n2)c1 InChI=1S/C17H15N7O2/c18-16(19)10-3-1-4-11(7-10)25-14-8-22-9-15(24-14)26-13-6-2-5-12(23-13)17(20)21/h1-9H,(H3,18,19)(H3,20,21) QXTCYPIVURITLG-UHFFFAOYSA-N 50077185 6-[6-(3-Carbamimidoyl-phenoxy)-pyrazin-2-yloxy]-pyridine-2-carboxamidine::CHEMBL45785 Coagulation factor X Homo sapiens 51 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077185&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44293746 103969993 CHEMBL45785 ZINC29416496 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134654 NC(=N)c1cccc(Oc2cc(Oc3ccccc3C(N)=N)ccc2N)c1 InChI=1S/C20H19N5O2/c21-16-9-8-14(26-17-7-2-1-6-15(17)20(24)25)11-18(16)27-13-5-3-4-12(10-13)19(22)23/h1-11H,21H2,(H3,22,23)(H3,24,25) KYXWBAVECHVHOH-UHFFFAOYSA-N 50077187 2-{4-amino-3-[3-amino(imino)methylphenoxy]phenoxy}phenyl-iminomethanamine::CHEMBL49370 Coagulation factor X Homo sapiens 1100 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077187&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44294121 103969995 CHEMBL49370 ZINC29465281 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134658 CNC(=O)c1ccc(Oc2cccc(c2)C(N)=N)nc1Oc1cccc(c1)C(N)=N InChI=1S/C21H20N6O3/c1-26-20(28)16-8-9-17(29-14-6-2-4-12(10-14)18(22)23)27-21(16)30-15-7-3-5-13(11-15)19(24)25/h2-11H,1H3,(H3,22,23)(H3,24,25)(H,26,28) KYFGCOJIFAOPLH-UHFFFAOYSA-N 50077188 2,6-Bis-(3-carbamimidoyl-phenoxy)-N-methyl-nicotinamide::CHEMBL296530 Coagulation factor X Homo sapiens 230 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077188&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10692578 103969996 CHEMBL296530 ZINC13797421 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134660 CN(C)C(=O)c1ccc(Oc2cccc(c2)C(N)=N)nc1Oc1cccc(c1)C(N)=N InChI=1S/C22H22N6O3/c1-28(2)22(29)17-9-10-18(30-15-7-3-5-13(11-15)19(23)24)27-21(17)31-16-8-4-6-14(12-16)20(25)26/h3-12H,1-2H3,(H3,23,24)(H3,25,26) YZZGIFYOGPXJKP-UHFFFAOYSA-N 50077169 2,6-Bis-(3-carbamimidoyl-phenoxy)-N,N-dimethyl-nicotinamide::CHEMBL52479 Coagulation factor X Homo sapiens 32 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077169&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10764466 103969977 CHEMBL52479 ZINC13797424 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134662 CN(c1cccc(c1)C(N)=N)c1nc(Oc2cccc(c2)C(N)=N)c(F)c(C)c1F InChI=1S/C21H20F2N6O/c1-11-16(22)20(29(2)14-7-3-5-12(9-14)18(24)25)28-21(17(11)23)30-15-8-4-6-13(10-15)19(26)27/h3-10H,1-2H3,(H3,24,25)(H3,26,27) ICDINSHVIKUFIQ-UHFFFAOYSA-N 50077190 2N-[3-amino(imino)methylphenyl]-2N,4-dimethyl-6-[3-amino(imino)methylphenoxy]-3,5-difluoro-2-pyridinamine::CHEMBL52205 Coagulation factor X Homo sapiens 12 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077190&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10549508 103969998 CHEMBL52205 ZINC13797459 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134668 NC(=N)c1cccc(Oc2ccc(C(O)=O)c(Oc3cccc(c3)C(N)=N)n2)c1 InChI=1S/C20H17N5O4/c21-17(22)11-3-1-5-13(9-11)28-16-8-7-15(20(26)27)19(25-16)29-14-6-2-4-12(10-14)18(23)24/h1-10H,(H3,21,22)(H3,23,24)(H,26,27) AGISMPMQZWVBJT-UHFFFAOYSA-N 50077178 2,6-Bis-(3-carbamimidoyl-phenoxy)-nicotinic acid::CHEMBL46077 Coagulation factor X Homo sapiens 95 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077178&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10596601 103969986 CHEMBL46077 ZINC13797433 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134671 NC(=N)c1ccc(Oc2nc(Oc3ccc(cc3)C(N)=N)c(Cl)cc2Cl)cc1 InChI=1S/C19H15Cl2N5O2/c20-14-9-15(21)19(28-13-7-3-11(4-8-13)17(24)25)26-18(14)27-12-5-1-10(2-6-12)16(22)23/h1-9H,(H3,22,23)(H3,24,25) HRUCQVIIUGSDPQ-UHFFFAOYSA-N 50066631 4-[3,5-Dichloro-6-(4-diaminomethyl-phenoxy)-pyridin-2-yloxy]-benzamidine::4-{6-[4-amino(imino)methylphenoxy]-3,5-dichloro-2-pyridyloxy}phenyl-iminomethanamine::CHEMBL49786 Coagulation factor X Homo sapiens 620 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066631&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10573919 103961251 CHEMBL49786 ZINC13781060 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134672 CNC(=O)Nc1ccc(Oc2cccc(c2)C(N)=N)nc1Oc1cccc(c1)C(N)=N InChI=1S/C21H21N7O3/c1-26-21(29)27-16-8-9-17(30-14-6-2-4-12(10-14)18(22)23)28-20(16)31-15-7-3-5-13(11-15)19(24)25/h2-11H,1H3,(H3,22,23)(H3,24,25)(H2,26,27,29) AMVVAPIBSORRDI-UHFFFAOYSA-N 50077171 2,6-di[3-amino-N-methyl carboxamide-(imino)methylphenoxy]-3-pyridinamine::CHEMBL51482 Coagulation factor X Homo sapiens 59 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077171&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10574097 103969979 CHEMBL51482 ZINC13797405 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134679 CS(=O)(=O)Nc1ccc(Oc2cccc(c2)C(N)=N)nc1Oc1cccc(c1)C(N)=N InChI=1S/C20H20N6O4S/c1-31(27,28)26-16-8-9-17(29-14-6-2-4-12(10-14)18(21)22)25-20(16)30-15-7-3-5-13(11-15)19(23)24/h2-11,26H,1H3,(H3,21,22)(H3,23,24) NQWZOZMPXIGWDF-UHFFFAOYSA-N 50077173 CHEMBL48595::N-{2,6-di[3-amino(imino)methylphenoxy]-3-pyridyl}methanesulfonamide Coagulation factor X Homo sapiens 130 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077173&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10646757 103969981 CHEMBL48595 ZINC13797398 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134687 NC(=N)c1cccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(F)cc2F)c1 InChI=1S/C19H15F2N5O2/c20-14-9-15(21)19(28-13-6-2-4-11(8-13)17(24)25)26-18(14)27-12-5-1-3-10(7-12)16(22)23/h1-9H,(H3,22,23)(H3,24,25) YSBKPPPTSBMIHQ-UHFFFAOYSA-N 50066640 3-{6-[3-amino(imino)methylphenoxy]-3,5-difluoro-2-pyridyloxy}phenyl-iminomethanamine::CHEMBL424036 Coagulation factor X Homo sapiens 24 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066640&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10691360 103961260 CHEMBL424036 ZINC13781063 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134691 CCOC(=O)c1cc(Oc2cccc(c2)C(N)=N)nc(Oc2cccc(c2)C(N)=N)c1 InChI=1S/C22H21N5O4/c1-2-29-22(28)15-11-18(30-16-7-3-5-13(9-16)20(23)24)27-19(12-15)31-17-8-4-6-14(10-17)21(25)26/h3-12H,2H2,1H3,(H3,23,24)(H3,25,26) ZCRCATCUHFHFSU-UHFFFAOYSA-N 50077184 2,6-Bis-(3-carbamimidoyl-phenoxy)-isonicotinic acid ethyl ester::CHEMBL48827 Coagulation factor X Homo sapiens 34 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077184&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10526100 103969992 CHEMBL48827 ZINC13797442 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134693 NC(=N)c1cccc(Oc2nc(Oc3cccc(c3)C(N)=N)c(Cl)cc2Cl)c1 InChI=1S/C19H15Cl2N5O2/c20-14-9-15(21)19(28-13-6-2-4-11(8-13)17(24)25)26-18(14)27-12-5-1-3-10(7-12)16(22)23/h1-9H,(H3,22,23)(H3,24,25) VBRBATJVFAKEBY-UHFFFAOYSA-N 50066629 3-{6-[3-amino(imino)methylphenoxy]-3,5-dichloro-2-pyridyloxy}phenyl-iminomethanamine::CHEMBL48864 Coagulation factor X Homo sapiens 130 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066629&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10525943 103961249 CHEMBL48864 ZINC13781061 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134694 CC(=N)N1CC[C@@H](C1)Oc1ccc(cc1)[C@H](Cc1ccc2ccc(cc2c1)C(N)=N)C(O)=O InChI=1S/C26H28N4O3/c1-16(27)30-11-10-23(15-30)33-22-8-6-19(7-9-22)24(26(31)32)13-17-2-3-18-4-5-20(25(28)29)14-21(18)12-17/h2-9,12,14,23-24,27H,10-11,13,15H2,1H3,(H3,28,29)(H,31,32)/t23-,24-/m0/s1 AGRCGQSFFMCBRE-ZEQRLZLVSA-N 17283 (2S)-3-(7-carbamimidoylnaphthalen-2-yl)-2-(4-{[(3S)-1-ethanimidoylpyrrolidin-3-yl]oxy}phenyl)propanoic acid::CHEMBL19902::DX-9065a Coagulation factor X Homo sapiens 22 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17283&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search DX9 1MTW,1FAX 122129 46517461 CHEMBL19902 ZINC03791107 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134695 COc1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2cccc(c2)C(N)=N)c1F InChI=1S/C20H17F2N5O3/c1-28-16-14(21)19(29-12-6-2-4-10(8-12)17(23)24)27-20(15(16)22)30-13-7-3-5-11(9-13)18(25)26/h2-9H,1H3,(H3,23,24)(H3,25,26) BFJZBNCCNIPTEK-UHFFFAOYSA-N 50077181 3-{6-[3-amino(imino)methylphenoxy]-3,5-difluoro-4-methoxy-2-pyridyloxy}phenyl-iminomethanamine::CHEMBL48965 Coagulation factor X Homo sapiens 23 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077181&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10835535 103969989 CHEMBL48965 ZINC13797389 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134697 CC(=O)Nc1ccc(Oc2cccc(c2)C(N)=N)nc1Oc1cccc(c1)C(N)=N InChI=1S/C21H20N6O3/c1-12(28)26-17-8-9-18(29-15-6-2-4-13(10-15)19(22)23)27-21(17)30-16-7-3-5-14(11-16)20(24)25/h2-11H,1H3,(H3,22,23)(H3,24,25)(H,26,28) ZNBMRULRQJAJNW-UHFFFAOYSA-N 50077172 CHEMBL49295::N-[2,6-Bis-(3-carbamimidoyl-phenoxy)-pyridin-3-yl]-acetamide Coagulation factor X Homo sapiens 52 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077172&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10501400 103969980 CHEMBL49295 ZINC13797395 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134698 CCOC(=O)c1ccc(Oc2cccc(c2)C(N)=N)nc1Oc1cccc(c1)C(N)=N InChI=1S/C22H21N5O4/c1-2-29-22(28)17-9-10-18(30-15-7-3-5-13(11-15)19(23)24)27-21(17)31-16-8-4-6-14(12-16)20(25)26/h3-12H,2H2,1H3,(H3,23,24)(H3,25,26) SLBCYMNSPJGIKG-UHFFFAOYSA-N 50077179 2,6-Bis-(3-carbamimidoyl-phenoxy)-nicotinic acid ethyl ester::CHEMBL48161 Coagulation factor X Homo sapiens 190 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077179&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10788206 103969987 CHEMBL48161 ZINC13797430 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134702 NC(=N)c1cccc(Oc2c[n+]([O-])cc(Oc3cccc(n3)C(N)=N)n2)c1 InChI=1S/C17H15N7O3/c18-16(19)10-3-1-4-11(7-10)26-14-8-24(25)9-15(23-14)27-13-6-2-5-12(22-13)17(20)21/h1-9H,(H3,18,19)(H3,20,21) FQVXKUYRRBORTQ-UHFFFAOYSA-N 50077192 6-[6-(3-Carbamimidoyl-phenoxy)-4-oxy-pyrazin-2-yloxy]-pyridine-2-carboxamidine::CHEMBL48497 Coagulation factor X Homo sapiens 180 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077192&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44294161 103970000 CHEMBL48497 ZINC29470820 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134704 NC(=N)c1ccc(Oc2cc(Oc3ccc(cc3)C(N)=N)c(Cl)cc2Cl)cc1 InChI=1S/C20H16Cl2N4O2/c21-15-9-16(22)18(28-14-7-3-12(4-8-14)20(25)26)10-17(15)27-13-5-1-11(2-6-13)19(23)24/h1-10H,(H3,23,24)(H3,25,26) OKSJBOAOAKZVSY-UHFFFAOYSA-N 50077175 4-(6-(4-amino(imino)methylphenoxy)-3,5-dichloro-2-pyridyloxy)phenyl-iminomethanamine::CHEMBL48691 Coagulation factor X Homo sapiens 1100 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077175&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10669525 103969983 CHEMBL48691 ZINC13797386 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134705 NC(=O)CNC(=O)c1ccc(Oc2cccc(c2)C(N)=N)nc1Oc1cccc(c1)C(N)=N InChI=1S/C22H21N7O4/c23-17(30)11-28-21(31)16-7-8-18(32-14-5-1-3-12(9-14)19(24)25)29-22(16)33-15-6-2-4-13(10-15)20(26)27/h1-10H,11H2,(H2,23,30)(H3,24,25)(H3,26,27)(H,28,31) YBMZQPAFMNIKID-UHFFFAOYSA-N 50077193 2,6-Bis-(3-carbamimidoyl-phenoxy)-N-carbamoylmethyl-nicotinamide::CHEMBL49358 Coagulation factor X Homo sapiens 690 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077193&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10694720 103970001 CHEMBL49358 ZINC13797427 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134708 NC(=N)c1cccc(Oc2nccc(Oc3cccc(n3)C(N)=N)n2)c1 InChI=1S/C17H15N7O2/c18-15(19)10-3-1-4-11(9-10)25-17-22-8-7-14(24-17)26-13-6-2-5-12(23-13)16(20)21/h1-9H,(H3,18,19)(H3,20,21) NGZIAJQDDOOBPP-UHFFFAOYSA-N 50077191 6-[2-(3-Carbamimidoyl-phenoxy)-pyrimidin-4-yloxy]-pyridine-2-carboxamidine::CHEMBL45732 Coagulation factor X Homo sapiens 120 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077191&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44293745 103969999 CHEMBL45732 ZINC29416493 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134709 NC(=N)c1ccccc1Oc1cccc(Oc2ccccc2C(N)=N)n1 InChI=1S/C19H17N5O2/c20-18(21)12-6-1-3-8-14(12)25-16-10-5-11-17(24-16)26-15-9-4-2-7-13(15)19(22)23/h1-11H,(H3,20,21)(H3,22,23) GFJGYFOGZBPJMD-UHFFFAOYSA-N 50077195 2-{6-[2-amino(imino)methylphenoxy]-2-pyridyloxy}phenyl-iminomethanamine::CHEMBL48045 Coagulation factor X Homo sapiens >5000 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077195&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10712659 103970003 CHEMBL48045 ZINC29411318 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134713 NC(=N)c1cccc(Oc2ccc(NC(=O)c3ccccc3)c(Oc3cccc(c3)C(N)=N)n2)c1 InChI=1S/C26H22N6O3/c27-23(28)17-8-4-10-19(14-17)34-22-13-12-21(31-25(33)16-6-2-1-3-7-16)26(32-22)35-20-11-5-9-18(15-20)24(29)30/h1-15H,(H3,27,28)(H3,29,30)(H,31,33) SCJOWVHNIQGJTQ-UHFFFAOYSA-N 50077189 CHEMBL295263::N-[2,6-Bis-(3-carbamimidoyl-phenoxy)-pyridin-3-yl]-benzamide Coagulation factor X Homo sapiens 120 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077189&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10837929 103969997 CHEMBL295263 ZINC13797408 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134714 NC(=N)c1cccc(Oc2ccc(C(N)=O)c(Oc3cccc(c3)C(N)=N)n2)c1 InChI=1S/C20H18N6O3/c21-17(22)11-3-1-5-13(9-11)28-16-8-7-15(19(25)27)20(26-16)29-14-6-2-4-12(10-14)18(23)24/h1-10H,(H3,21,22)(H3,23,24)(H2,25,27) AHGDYLUQZBUCBX-UHFFFAOYSA-N 50077176 2,6-Bis-(3-carbamimidoyl-phenoxy)-nicotinamide::CHEMBL48206 Coagulation factor X Homo sapiens 600 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077176&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10548429 103969984 CHEMBL48206 ZINC13797418 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134715 NC(=N)c1cccc(Oc2ccc(N)c(Oc3cccc(c3)C(N)=N)n2)c1 InChI=1S/C19H18N6O2/c20-15-7-8-16(26-13-5-1-3-11(9-13)17(21)22)25-19(15)27-14-6-2-4-12(10-14)18(23)24/h1-10H,20H2,(H3,21,22)(H3,23,24) QQSLTWQLYHGECT-UHFFFAOYSA-N 50077186 2,6-di[3-amino(imino)methylphenoxy]-3-pyridinamine::CHEMBL47264 Coagulation factor X Homo sapiens 53 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077186&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10642387 103969994 CHEMBL47264 ZINC13797392 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134718 Cc1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2cccc(c2)C(N)=N)c1F InChI=1S/C20H17F2N5O2/c1-10-15(21)19(28-13-6-2-4-11(8-13)17(23)24)27-20(16(10)22)29-14-7-3-5-12(9-14)18(25)26/h2-9H,1H3,(H3,23,24)(H3,25,26) ZXIHYCYAQUQHSG-UHFFFAOYSA-N 17278 3-{[6-(3-carbamimidoylphenoxy)-3,5-difluoro-4-methylpyridin-2-yl]oxy}benzene-1-carboximidamide::CHEMBL49636::Pyridine template, III::ZK-805623 Coagulation factor X Homo sapiens 13 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17278&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 1QB6 448061 46517456 CHEMBL49636 ZINC00585999 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134721 CN(c1cccc(c1)C(N)=N)c1nc(N(C)c2cccc(c2)C(N)=N)c(F)c(C)c1F InChI=1S/C22H23F2N7/c1-12-17(23)21(30(2)15-8-4-6-13(10-15)19(25)26)29-22(18(12)24)31(3)16-9-5-7-14(11-16)20(27)28/h4-11H,1-3H3,(H3,25,26)(H3,27,28) UZBVVTXNCWEYTB-UHFFFAOYSA-N 50077183 2N,6N-di[3-amino(imino)methylphenyl]-2N,4,6N-trimethyl-3,5-difluoro-2,6-pyridinediamine::CHEMBL49958 Coagulation factor X Homo sapiens 98 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077183&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10502393 103969991 CHEMBL49958 ZINC13797462 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134725 NC(=N)c1cccc(Oc2ccc(c(Oc3cccc(c3)C(N)=N)n2)C(F)(F)F)c1 InChI=1S/C20H16F3N5O2/c21-20(22,23)15-7-8-16(29-13-5-1-3-11(9-13)17(24)25)28-19(15)30-14-6-2-4-12(10-14)18(26)27/h1-10H,(H3,24,25)(H3,26,27) KZMJCQZBMNVBKC-UHFFFAOYSA-N 50077194 3-{6-[3-amino(imino)methylphenoxy]-3-trifluoromethyl-2-pyridyloxy}phenyl-iminomethanamine::CHEMBL50714 Coagulation factor X Homo sapiens 110 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077194&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10835646 103970002 CHEMBL50714 ZINC13797415 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50131599 Cc1cc2cc(ccc2o1)N=C(N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O)C(C#N)C(=O)OCCCCO InChI=1S/C29H37N5O6/c1-20-16-21-17-22(9-10-25(21)40-20)31-27(23(18-30)29(38)39-15-7-6-14-35)32-24-8-2-3-13-34(28(24)37)19-26(36)33-11-4-5-12-33/h9-10,16-17,23-24,35H,2-8,11-15,19H2,1H3,(H,31,32)/t23?,24-/m0/s1 CMLPKFXOBMIEHA-CGAIIQECSA-N 50175075 (S,Z)-4-hydroxybutyl 2-cyano-3-(2-methylbenzofuran-5-ylamino)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-ylamino)acrylate::CHEMBL198629 Coagulation factor X Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2005.08.107 10.7270/Q2KH0MW5 16213711 Shi, Y; Zhang, J; Stein, PD; Shi, M; O'Connor, SP; Bisaha, SN; Li, C; Atwal, KS; Bisacchi, GS; Sitkoff, D; Pudzianowski, AT; Liu, EC; Hartl, KS; Seiler, SM; Youssef, S; Steinbacher, TE; Schumacher, WA; Rendina, AR; Bozarth, JM; Peterson, TL; Zhang, G; Zahler, R Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175075&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 90928933 104060816 CHEMBL198629 ZINC34689198 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50132690 NC(=N)NCCC[C@@H](CCl)NC(=O)[C@@H]1CCN2CC[C@@](N)(Cc3ccccc3)CN12 InChI=1S/C21H34ClN7O/c22-14-17(7-4-10-26-20(23)24)27-19(30)18-8-11-28-12-9-21(25,15-29(18)28)13-16-5-2-1-3-6-16/h1-3,5-6,17-18H,4,7-15,25H2,(H,27,30)(H4,23,24,26)/t17-,18-,21+/m0/s1 JSPAUBUYPPZXSG-BBTUJRGHSA-N 50076220 (1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]pyridazine-1-carboxylic acid ((S)-1-chloromethyl-4-guanidino-butyl)-amide::CHEMBL284436 Coagulation factor X Homo sapiens 385 ChEMBL 10.1021/jm980354p 10.7270/Q20Z72G1 10212122 Boatman, PD; Ogbu, CO; Eguchi, M; Kim, HO; Nakanishi, H; Cao, B; Shea, JP; Kahn, M Molecumetics Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076220&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44278104 103969153 CHEMBL284436 ZINC28770106 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50132697 NC(=N)NCCC[C@H](NC(=O)[C@@H]1CCN2CC[C@@](N)(Cc3ccccc3)CN12)C(=O)c1nc2ccccc2s1 InChI=1S/C28H36N8O2S/c29-27(30)32-14-6-10-21(24(37)26-34-20-9-4-5-11-23(20)39-26)33-25(38)22-12-15-35-16-13-28(31,18-36(22)35)17-19-7-2-1-3-8-19/h1-5,7-9,11,21-22H,6,10,12-18,31H2,(H,33,38)(H4,29,30,32)/t21-,22-,28+/m0/s1 WQDOEYAJPUSQCH-RXYILKCJSA-N 50076222 (1S,7S)-7-Amino-7-benzyl-hexahydro-pyrazolo[1,2-a]pyridazine-1-carboxylic acid [(S)-1-(benzothiazole-2-carbonyl)-4-guanidino-butyl]-amide::CHEMBL282830 Coagulation factor X Homo sapiens 270 ChEMBL 10.1021/jm980354p 10.7270/Q20Z72G1 10212122 Boatman, PD; Ogbu, CO; Eguchi, M; Kim, HO; Nakanishi, H; Cao, B; Shea, JP; Kahn, M Molecumetics Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076222&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9937406 103969155 CHEMBL282830 ZINC28770444 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50132709 NC(=N)NCCC[C@H](NC(=O)[C@@H]1CCC2CC[C@@](N)(Cc3ccccc3)CN12)C(=O)c1nc2ccccc2s1 InChI=1S/C29H37N7O2S/c30-28(31)33-16-6-10-22(25(37)27-35-21-9-4-5-11-24(21)39-27)34-26(38)23-13-12-20-14-15-29(32,18-36(20)23)17-19-7-2-1-3-8-19/h1-5,7-9,11,20,22-23H,6,10,12-18,32H2,(H,34,38)(H4,30,31,33)/t20?,22-,23-,29+/m0/s1 MJPRZTFMWHJGMK-FFILHAAMSA-N 50076219 (3S,6R)-6-Amino-6-benzyl-octahydro-indolizine-3-carboxylic acid [(S)-1-(benzothiazole-2-carbonyl)-4-guanidino-butyl]-amide::CHEMBL27852 Coagulation factor X Homo sapiens 19.3 ChEMBL 10.1021/jm980354p 10.7270/Q20Z72G1 10212122 Boatman, PD; Ogbu, CO; Eguchi, M; Kim, HO; Nakanishi, H; Cao, B; Shea, JP; Kahn, M Molecumetics Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076219&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9850467 103969152 CHEMBL27852 ZINC28770757 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50132718 N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCl)CCCNC(N)=N InChI=1S/C20H31ClN6O2/c21-13-15(8-4-10-25-20(23)24)26-18(28)17-9-5-11-27(17)19(29)16(22)12-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13,22H2,(H,26,28)(H4,23,24,25)/t15-,16+,17-/m0/s1 BRZYOTMFHLERHD-BBWFWOEESA-N 50076221 (S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid ((S)-1-chloromethyl-4-guanidino-butyl)-amide::CHEMBL265315 Coagulation factor X Homo sapiens 165 ChEMBL 10.1021/jm980354p 10.7270/Q20Z72G1 10212122 Boatman, PD; Ogbu, CO; Eguchi, M; Kim, HO; Nakanishi, H; Cao, B; Shea, JP; Kahn, M Molecumetics Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076221&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9910164 103969154 CHEMBL265315 ZINC28769778 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50133868 CNc1ccc(cc1)C#CC[C@H](NS(=O)(=O)c1ccc2ccccc2c1)C(=O)N(C)C1CCCC1 InChI=1S/C28H31N3O3S/c1-29-24-17-14-21(15-18-24)8-7-13-27(28(32)31(2)25-11-5-6-12-25)30-35(33,34)26-19-16-22-9-3-4-10-23(22)20-26/h3-4,9-10,14-20,25,27,29-30H,5-6,11-13H2,1-2H3/t27-/m0/s1 RCTWBEIFOZSNKC-MHZLTWQESA-N 50076724 (S)-5-(4-Methylamino-phenyl)-2-(naphthalene-2-sulfonylamino)-pent-4-ynoic acid cyclopentyl-methyl-amide::CHEMBL415479 Coagulation factor X Homo sapiens 8700.0 ChEMBL 10.1016/s0960-894x(99)00125-0 10.7270/Q298866C 10230630 Lee, K; Hwang, SY; Park, CW Biotech Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076724&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44264598 103969595 CHEMBL415479 ZINC25969220 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134115 COC(=O)[C@H]1CN(Cc2ccc(cc2)-c2ccccc2S(N)(=O)=O)C[C@@H]1c1cccc(c1)C(N)=N InChI=1S/C26H28N4O4S/c1-34-26(31)23-16-30(15-22(23)19-5-4-6-20(13-19)25(27)28)14-17-9-11-18(12-10-17)21-7-2-3-8-24(21)35(29,32)33/h2-13,22-23H,14-16H2,1H3,(H3,27,28)(H2,29,32,33)/t22-,23+/m1/s1 VXVOMLLAAQVNLR-PKTZIBPZSA-N 50076908 (3R,4S)-4-(3-Carbamimidoyl-phenyl)-1-(2'-sulfamoyl-biphenyl-4-ylmethyl)-pyrrolidine-3-carboxylic acid methyl ester with 2M of TFA::CHEMBL277994 Coagulation factor X Homo sapiens 13 ChEMBL 10.1016/s0960-894x(99)00164-x 10.7270/Q20V8BZZ 10328312 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076908&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 15463577 103969773 CHEMBL277994 ZINC28221025 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134120 CCCCOC(=O)[C@@H]1CN(Cc2ccc(cc2)-c2ccccc2S(N)(=O)=O)C[C@H]1c1cccc(c1)C(N)=N InChI=1S/C29H34N4O4S/c1-2-3-15-37-29(34)26-19-33(18-25(26)22-7-6-8-23(16-22)28(30)31)17-20-11-13-21(14-12-20)24-9-4-5-10-27(24)38(32,35)36/h4-14,16,25-26H,2-3,15,17-19H2,1H3,(H3,30,31)(H2,32,35,36)/t25-,26+/m0/s1 GGSVKXFKOZNQGL-IZZNHLLZSA-N 50076912 (3S,4R)-4-(3-Carbamimidoyl-phenyl)-1-(2'-sulfamoyl-biphenyl-4-ylmethyl)-pyrrolidine-3-carboxylic acid butyl ester with 2M of TFA::CHEMBL429068 Coagulation factor X Homo sapiens 12 ChEMBL 10.1016/s0960-894x(99)00164-x 10.7270/Q20V8BZZ 10328312 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076912&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 15463580 103969777 CHEMBL429068 ZINC28222697 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134122 NC(=N)c1cccc(c1)[C@@H]1CN(Cc2ccc(cc2)-c2ccccc2S(N)(=O)=O)C[C@H]1C(O)=O InChI=1S/C25H26N4O4S/c26-24(27)19-5-3-4-18(12-19)21-14-29(15-22(21)25(30)31)13-16-8-10-17(11-9-16)20-6-1-2-7-23(20)34(28,32)33/h1-12,21-22H,13-15H2,(H3,26,27)(H,30,31)(H2,28,32,33)/t21-,22+/m0/s1 ZFAKBHPIEAWJLD-FCHUYYIVSA-N 50076915 (3S,4R)-4-(3-Carbamimidoyl-phenyl)-1-(2'-sulfamoyl-biphenyl-4-ylmethyl)-pyrrolidine-3-carboxylic acid with 2M of TFA::CHEMBL435761 Coagulation factor X Homo sapiens 600 ChEMBL 10.1016/s0960-894x(99)00164-x 10.7270/Q20V8BZZ 10328312 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076915&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44272560 103969780 CHEMBL435761 ZINC01903116 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134124 CCOC(=O)[C@]1(C)CN(Cc2ccc(cc2)-c2ccccc2S(N)(=O)=O)C[C@H]1c1cccc(c1)C(N)=N InChI=1S/C28H32N4O4S/c1-3-36-27(33)28(2)18-32(17-24(28)21-7-6-8-22(15-21)26(29)30)16-19-11-13-20(14-12-19)23-9-4-5-10-25(23)37(31,34)35/h4-15,24H,3,16-18H2,1-2H3,(H3,29,30)(H2,31,34,35)/t24-,28+/m0/s1 SVASUNOMHIDAOX-RBJSKKJNSA-N 50076914 (3S,4S)-4-(3-Carbamimidoyl-phenyl)-3-methyl-1-(2'-sulfamoyl-biphenyl-4-ylmethyl)-pyrrolidine-3-carboxylic acid ethyl ester with 2M of TFA::CHEMBL275582 Coagulation factor X Homo sapiens 26 ChEMBL 10.1016/s0960-894x(99)00164-x 10.7270/Q20V8BZZ 10328312 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076914&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 15463581 103969779 CHEMBL275582 ZINC28223010 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134125 CC(=O)[C@@H]1CN(Cc2ccc(cc2)-c2ccccc2S(N)(=O)=O)C[C@H]1c1cccc(c1)C(N)=N InChI=1S/C26H28N4O3S/c1-17(31)23-15-30(16-24(23)20-5-4-6-21(13-20)26(27)28)14-18-9-11-19(12-10-18)22-7-2-3-8-25(22)34(29,32)33/h2-13,23-24H,14-16H2,1H3,(H3,27,28)(H2,29,32,33)/t23-,24-/m0/s1 VNMJDJUMSGRWPP-ZEQRLZLVSA-N 50076916 3-[(3R,4S)-4-Acetyl-1-(2'-sulfamoyl-biphenyl-4-ylmethyl)-pyrrolidin-3-yl]-benzamidine with 2M of TFA::CHEMBL18627 Coagulation factor X Homo sapiens 36 ChEMBL 10.1016/s0960-894x(99)00164-x 10.7270/Q20V8BZZ 10328312 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076916&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44272530 103969781 CHEMBL18627 ZINC28223070 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134127 NC(=O)[C@@H]1CN(Cc2ccc(cc2)-c2ccccc2S(N)(=O)=O)C[C@H]1c1cccc(c1)C(N)=N InChI=1S/C25H27N5O3S/c26-24(27)19-5-3-4-18(12-19)21-14-30(15-22(21)25(28)31)13-16-8-10-17(11-9-16)20-6-1-2-7-23(20)34(29,32)33/h1-12,21-22H,13-15H2,(H3,26,27)(H2,28,31)(H2,29,32,33)/t21-,22+/m0/s1 XXSUCSCMAHVAOP-FCHUYYIVSA-N 50076913 (3S,4R)-4-(3-Carbamimidoyl-phenyl)-1-(2'-sulfamoyl-biphenyl-4-ylmethyl)-pyrrolidine-3-carboxylic acid amide with 2M of TFA::CHEMBL19038 Coagulation factor X Homo sapiens 150 ChEMBL 10.1016/s0960-894x(99)00164-x 10.7270/Q20V8BZZ 10328312 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076913&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44272581 103969778 CHEMBL19038 ZINC28223365 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134130 CC(C)OC(=O)[C@@H]1CN(Cc2ccc(cc2)-c2ccccc2S(N)(=O)=O)O[C@H]1c1cccc(c1)C(N)=N InChI=1S/C27H30N4O5S/c1-17(2)35-27(32)23-16-31(36-25(23)20-6-5-7-21(14-20)26(28)29)15-18-10-12-19(13-11-18)22-8-3-4-9-24(22)37(30,33)34/h3-14,17,23,25H,15-16H2,1-2H3,(H3,28,29)(H2,30,33,34)/t23-,25+/m1/s1 MPIZHZHLXIHDRD-NOZRDPDXSA-N 50076911 (4R,5R)-5-(3-Carbamimidoyl-phenyl)-2-(2'-sulfamoyl-biphenyl-4-ylmethyl)-isoxazolidine-4-carboxylic acid isopropyl ester with 2M of TFA::CHEMBL18578 Coagulation factor X Homo sapiens 1.8 ChEMBL 10.1016/s0960-894x(99)00164-x 10.7270/Q20V8BZZ 10328312 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076911&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10075442 103969776 CHEMBL18578 ZINC28220439 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134132 COC(=O)CN(CCCc1ccc(cc1)-c1ccccc1S(N)(=O)=O)c1cccc(c1)C(N)=N InChI=1S/C25H28N4O4S/c1-33-24(30)17-29(21-8-4-7-20(16-21)25(26)27)15-5-6-18-11-13-19(14-12-18)22-9-2-3-10-23(22)34(28,31)32/h2-4,7-14,16H,5-6,15,17H2,1H3,(H3,26,27)(H2,28,31,32) WTZPFQZXGTVVPM-UHFFFAOYSA-N 50072448 CHEMBL18767::{(3-Carbamimidoyl-phenyl)-[3-(2'-sulfamoyl-biphenyl-4-yl)-propyl]-amino}-acetic acid methyl ester; TFA Coagulation factor X Homo sapiens 1.3 ChEMBL 10.1016/s0960-894x(99)00164-x 10.7270/Q20V8BZZ 10328312 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072448&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10054210 103966076 CHEMBL18767 ZINC01895091 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134133 CC(C)OC(=O)[C@@H]1CN(Cc2ccc(cc2)-c2ccccc2S(N)(=O)=O)C[C@H]1c1cccc(c1)C(N)=N InChI=1S/C28H32N4O4S/c1-18(2)36-28(33)25-17-32(16-24(25)21-6-5-7-22(14-21)27(29)30)15-19-10-12-20(13-11-19)23-8-3-4-9-26(23)37(31,34)35/h3-14,18,24-25H,15-17H2,1-2H3,(H3,29,30)(H2,31,34,35)/t24-,25+/m0/s1 NWNRXYIFWXPWLQ-LOSJGSFVSA-N 50076917 (3S,4R)-4-(3-Carbamimidoyl-phenyl)-1-(2'-sulfamoyl-biphenyl-4-ylmethyl)-pyrrolidine-3-carboxylic acid isopropyl ester with 2M of TFA::CHEMBL276782 Coagulation factor X Homo sapiens 5.8 ChEMBL 10.1016/s0960-894x(99)00164-x 10.7270/Q20V8BZZ 10328312 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076917&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44272532 103969782 CHEMBL276782 ZINC28223075 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134134 NC(=N)c1cccc(c1)[C@@H]1CN(Cc2ccc(cc2)-c2ccccc2S(N)(=O)=O)C[C@@H]1C(O)=O InChI=1S/C25H26N4O4S/c26-24(27)19-5-3-4-18(12-19)21-14-29(15-22(21)25(30)31)13-16-8-10-17(11-9-16)20-6-1-2-7-23(20)34(28,32)33/h1-12,21-22H,13-15H2,(H3,26,27)(H,30,31)(H2,28,32,33)/t21-,22-/m0/s1 ZFAKBHPIEAWJLD-VXKWHMMOSA-N 50076918 (3R,4R)-4-(3-Carbamimidoyl-phenyl)-1-(2'-sulfamoyl-biphenyl-4-ylmethyl)-pyrrolidine-3-carboxylic acid with 2M of TFA::CHEMBL277366 Coagulation factor X Homo sapiens 460 ChEMBL 10.1016/s0960-894x(99)00164-x 10.7270/Q20V8BZZ 10328312 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076918&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 15463579 103969783 CHEMBL277366 ZINC28223480 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134136 COC(=O)[C@@H]1CN(Cc2ccc(cc2)-c2ccccc2S(N)(=O)=O)O[C@H]1c1cccc(c1)C(N)=N InChI=1S/C25H26N4O5S/c1-33-25(30)21-15-29(34-23(21)18-5-4-6-19(13-18)24(26)27)14-16-9-11-17(12-10-16)20-7-2-3-8-22(20)35(28,31)32/h2-13,21,23H,14-15H2,1H3,(H3,26,27)(H2,28,31,32)/t21-,23+/m1/s1 IAUMSDOPUSJDIU-GGAORHGYSA-N 50076909 (4R,5R)-5-(3-Carbamimidoyl-phenyl)-2-(2'-sulfamoyl-biphenyl-4-ylmethyl)-isoxazolidine-4-carboxylic acid methyl ester with 2M of TFA::CHEMBL279267 Coagulation factor X Homo sapiens 3.1 ChEMBL 10.1016/s0960-894x(99)00164-x 10.7270/Q20V8BZZ 10328312 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076909&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44272562 103969774 CHEMBL279267 ZINC28225901 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134137 COC(=O)CC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C26H25N5O6S/c1-36-23(32)15-26(14-21(31-37-26)17-5-4-6-18(13-17)24(27)28)25(33)30-19-11-9-16(10-12-19)20-7-2-3-8-22(20)38(29,34)35/h2-13H,14-15H2,1H3,(H3,27,28)(H,30,33)(H2,29,34,35) QMEXGOMLMAXBEB-UHFFFAOYSA-N 50072445 CHEMBL139063::CHEMBL279628::[3-(3-Carbamimidoyl-phenyl)-5-(2'-sulfamoyl-biphenyl-4-ylcarbamoyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid methyl ester; TFA Coagulation factor X Homo sapiens 6.3 ChEMBL 10.1016/s0960-894x(99)00164-x 10.7270/Q20V8BZZ 10328312 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072445&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9936983 103966073 CHEMBL279628CHEMBL139063 ZINC14113515 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134138 COC(=O)[C@H]1CN(Cc2ccc(cc2)-c2ccccc2S(N)(=O)=O)C[C@H]1c1cccc(c1)C(N)=N InChI=1S/C26H28N4O4S/c1-34-26(31)23-16-30(15-22(23)19-5-4-6-20(13-19)25(27)28)14-17-9-11-18(12-10-17)21-7-2-3-8-24(21)35(29,32)33/h2-13,22-23H,14-16H2,1H3,(H3,27,28)(H2,29,32,33)/t22-,23-/m0/s1 VXVOMLLAAQVNLR-GOTSBHOMSA-N 50076910 (3R,4R)-4-(3-Carbamimidoyl-phenyl)-1-(2'-sulfamoyl-biphenyl-4-ylmethyl)-pyrrolidine-3-carboxylic acid methyl ester with 2M of TFA::CHEMBL19075 Coagulation factor X Homo sapiens 170 ChEMBL 10.1016/s0960-894x(99)00164-x 10.7270/Q20V8BZZ 10328312 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076910&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21968289 103969775 CHEMBL19075 ZINC28222207 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134139 CN(C)C(=O)[C@@H]1CN(Cc2ccc(cc2)-c2ccccc2S(N)(=O)=O)C[C@H]1c1cccc(c1)C(N)=N InChI=1S/C27H31N5O3S/c1-31(2)27(33)24-17-32(16-23(24)20-6-5-7-21(14-20)26(28)29)15-18-10-12-19(13-11-18)22-8-3-4-9-25(22)36(30,34)35/h3-14,23-24H,15-17H2,1-2H3,(H3,28,29)(H2,30,34,35)/t23-,24+/m0/s1 LQIYKFLTUSNOOI-BJKOFHAPSA-N 50076919 (3S,4R)-4-(3-Carbamimidoyl-phenyl)-1-(2'-sulfamoyl-biphenyl-4-ylmethyl)-pyrrolidine-3-carboxylic acid dimethylamide with 2M of TFA::CHEMBL19090 Coagulation factor X Homo sapiens 400 ChEMBL 10.1016/s0960-894x(99)00164-x 10.7270/Q20V8BZZ 10328312 Fevig, JM; Buriak, J; Stouten, PF; Knabb, RM; Lam, GN; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076919&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 15463578 103969784 CHEMBL19090 ZINC28223361 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50132480 CNS(=O)(=O)Nc1c(CCc2ccccc2)ccn(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)c1=O InChI=1S/C22H31N7O5S/c1-25-35(33,34)27-19-16(10-9-15-6-3-2-4-7-15)11-13-28(21(19)32)14-18(30)26-17-8-5-12-29(20(17)31)22(23)24/h2-4,6-7,11,13,17,20,25,27,31H,5,8-10,12,14H2,1H3,(H3,23,24)(H,26,30)/t17-,20?/m0/s1 GZQAVBWKRJZVED-DIMJTDRSSA-N 50076069 1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro-5-pyridinyl]-2-(3-methylamino(sulfonyl)amino-2-oxo-4-phenethyl-1,2-dihydro-1-pyridinyl)acetamide::CHEMBL171271 Coagulation factor X Homo sapiens 2500 ChEMBL 10.1016/s0960-894x(99)00102-x 10.7270/Q2NS0T3Q 10206557 Reiner, JE; Lim-Wilby, MS; Brunck, TK; Ha-Uong, T; Goldman, EA; Abelman, MA; Nutt, RF; Semple, JE; Tamura, SY Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076069&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44382391 103969065 CHEMBL171271 ZINC28000547 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50132483 CC(=O)Nc1c(CCc2ccccc2)ccn(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)c1=O InChI=1S/C23H30N6O4/c1-15(30)26-20-17(10-9-16-6-3-2-4-7-16)11-13-28(22(20)33)14-19(31)27-18-8-5-12-29(21(18)32)23(24)25/h2-4,6-7,11,13,18,21,32H,5,8-10,12,14H2,1H3,(H3,24,25)(H,26,30)(H,27,31)/t18-,21?/m0/s1 CWLVNFRXPCBYGB-YMXDCFFPSA-N 50076072 1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro-5-pyridinyl]-2-(3-methylcarboxamido-2-oxo-4-phenethyl-1,2-dihydro-1-pyridinyl)acetamide::CHEMBL171122 Coagulation factor X Homo sapiens >2500 ChEMBL 10.1016/s0960-894x(99)00102-x 10.7270/Q2NS0T3Q 10206557 Reiner, JE; Lim-Wilby, MS; Brunck, TK; Ha-Uong, T; Goldman, EA; Abelman, MA; Nutt, RF; Semple, JE; Tamura, SY Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076072&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44382441 103969068 CHEMBL171122 ZINC28003966 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50132486 NC(=N)N1CCC[C@H](NC(=O)Cn2ccc(CCc3ccccc3)c(NS(=O)(=O)c3ccccc3)c2=O)C1O InChI=1S/C27H32N6O5S/c28-27(29)33-16-7-12-22(25(33)35)30-23(34)18-32-17-15-20(14-13-19-8-3-1-4-9-19)24(26(32)36)31-39(37,38)21-10-5-2-6-11-21/h1-6,8-11,15,17,22,25,31,35H,7,12-14,16,18H2,(H3,28,29)(H,30,34)/t22-,25?/m0/s1 RSMCTJCDYYJLAI-XADRRFQNSA-N 50076068 1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro-5-pyridinyl]-2-(2-oxo-4-phenethyl-3-phenylsulfonamido-1,2-dihydro-1-pyridinyl)acetamide::CHEMBL174431 Coagulation factor X Homo sapiens 2360 ChEMBL 10.1016/s0960-894x(99)00102-x 10.7270/Q2NS0T3Q 10206557 Reiner, JE; Lim-Wilby, MS; Brunck, TK; Ha-Uong, T; Goldman, EA; Abelman, MA; Nutt, RF; Semple, JE; Tamura, SY Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076068&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44383543 103969064 CHEMBL174431 ZINC28007957 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50132489 NC(=N)N1CCC[C@H](NC(=O)Cn2ccc(CCc3ccccc3)c(NS(=O)(=O)CC(F)(F)F)c2=O)C1O InChI=1S/C23H29F3N6O5S/c24-23(25,26)14-38(36,37)30-19-16(9-8-15-5-2-1-3-6-15)10-12-31(21(19)35)13-18(33)29-17-7-4-11-32(20(17)34)22(27)28/h1-3,5-6,10,12,17,20,30,34H,4,7-9,11,13-14H2,(H3,27,28)(H,29,33)/t17-,20?/m0/s1 QZQQGWLVAUEZSU-DIMJTDRSSA-N 50076071 1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro-5-pyridinyl]-2-[2-oxo-4-phenethyl-3-(2,2,2-trifluoroethylsulfonamido)-1,2-dihydro-1-pyridinyl]acetamide::CHEMBL414832 Coagulation factor X Homo sapiens >2500 ChEMBL 10.1016/s0960-894x(99)00102-x 10.7270/Q2NS0T3Q 10206557 Reiner, JE; Lim-Wilby, MS; Brunck, TK; Ha-Uong, T; Goldman, EA; Abelman, MA; Nutt, RF; Semple, JE; Tamura, SY Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076071&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44383542 103969067 CHEMBL414832 ZINC28007948 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50132492 NC(=N)N1CCC[C@H](NC(=O)Cn2cccc(NS(=O)(=O)Cc3ccccc3)c2=O)C1O InChI=1S/C20H26N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-4,6-7,9-10,15,19,24,29H,5,8,11-13H2,(H3,21,22)(H,23,27)/t15-,19?/m0/s1 OSTVSACFFDGYPT-FUKCDUGKSA-N 50076074 1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro-5-pyridinyl]-2-(3-benzylsulfonamido-2-oxo-1,2-dihydro-1-pyridinyl)acetamide::CHEMBL41267::N-((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-(2-oxo-3-phenylmethanesulfonylamino-2H-pyridin-1-yl)-acetamide Coagulation factor X Homo sapiens 21 ChEMBL 10.1016/s0960-894x(99)00102-x 10.7270/Q2NS0T3Q 10206557 Reiner, JE; Lim-Wilby, MS; Brunck, TK; Ha-Uong, T; Goldman, EA; Abelman, MA; Nutt, RF; Semple, JE; Tamura, SY Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076074&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9890541 103969070 CHEMBL41267 ZINC29341166 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50132497 CS(=O)(=O)Nc1c(CCC2CCCCC2)ccn(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)c1=O InChI=1S/C22H36N6O5S/c1-34(32,33)26-19-16(10-9-15-6-3-2-4-7-15)11-13-27(21(19)31)14-18(29)25-17-8-5-12-28(20(17)30)22(23)24/h11,13,15,17,20,26,30H,2-10,12,14H2,1H3,(H3,23,24)(H,25,29)/t17-,20?/m0/s1 XARBHAVVGPUFRH-DIMJTDRSSA-N 50076067 1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro-5-pyridinyl]-2-[4-(2-cyclohexylethyl)-3-methylsulfonamido-2-oxo-1,2-dihydro-1-pyridinyl]acetamide::CHEMBL170338 Coagulation factor X Homo sapiens 2500 ChEMBL 10.1016/s0960-894x(99)00102-x 10.7270/Q2NS0T3Q 10206557 Reiner, JE; Lim-Wilby, MS; Brunck, TK; Ha-Uong, T; Goldman, EA; Abelman, MA; Nutt, RF; Semple, JE; Tamura, SY Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076067&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44382389 103969063 CHEMBL170338 ZINC28000503 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50132503 NC(=N)N1CCC[C@H](NC(=O)CN2CCCC(NS(=O)(=O)Cc3ccccc3)C2=O)C1O InChI=1S/C20H30N6O5S/c21-20(22)26-11-5-8-15(19(26)29)23-17(27)12-25-10-4-9-16(18(25)28)24-32(30,31)13-14-6-2-1-3-7-14/h1-3,6-7,15-16,19,24,29H,4-5,8-13H2,(H3,21,22)(H,23,27)/t15-,16?,19?/m0/s1 SPUAEQJRVQHWKF-LYGPFTKASA-N 50076073 1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro-5-pyridinyl]-2-(3-benzylsulfonamido-2-oxohexahydro-1-pyridinyl)acetamide::CHEMBL170457 Coagulation factor X Homo sapiens 2500 ChEMBL 10.1016/s0960-894x(99)00102-x 10.7270/Q2NS0T3Q 10206557 Reiner, JE; Lim-Wilby, MS; Brunck, TK; Ha-Uong, T; Goldman, EA; Abelman, MA; Nutt, RF; Semple, JE; Tamura, SY Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076073&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44383081 103969069 CHEMBL170457 ZINC36107662 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50132504 CS(=O)(=O)Nc1c(CCCc2ccccc2)ccn(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)c1=O InChI=1S/C23H32N6O5S/c1-35(33,34)27-20-17(10-5-9-16-7-3-2-4-8-16)12-14-28(22(20)32)15-19(30)26-18-11-6-13-29(21(18)31)23(24)25/h2-4,7-8,12,14,18,21,27,31H,5-6,9-11,13,15H2,1H3,(H3,24,25)(H,26,30)/t18-,21?/m0/s1 LRWLFVYSHODFIA-YMXDCFFPSA-N 50076066 1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro-5-pyridinyl]-2-[3-methylsulfonamido-2-oxo-4-(3-phenylpropyl)-1,2-dihydro-1-pyridinyl]acetamide::CHEMBL170400 Coagulation factor X Homo sapiens >2500 ChEMBL 10.1016/s0960-894x(99)00102-x 10.7270/Q2NS0T3Q 10206557 Reiner, JE; Lim-Wilby, MS; Brunck, TK; Ha-Uong, T; Goldman, EA; Abelman, MA; Nutt, RF; Semple, JE; Tamura, SY Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076066&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44383425 103969062 CHEMBL170400 ZINC28005133 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50132505 CS(=O)(=O)Nc1c(CCc2ccccc2)ccn(CC(=O)N[C@H]2CCCN(C2O)C(N)=N)c1=O InChI=1S/C22H30N6O5S/c1-34(32,33)26-19-16(10-9-15-6-3-2-4-7-15)11-13-27(21(19)31)14-18(29)25-17-8-5-12-28(20(17)30)22(23)24/h2-4,6-7,11,13,17,20,26,30H,5,8-10,12,14H2,1H3,(H3,23,24)(H,25,29)/t17-,20?/m0/s1 ZRYFGPLHJNIDEH-DIMJTDRSSA-N 50076070 1N-[1-amino(imino)methyl-6-hydroxy-(5S)-tetrahydro-5-pyridinyl]-2-(3-methylsulfonamido-2-oxo-4-phenethyl-1,2-dihydro-1-pyridinyl)acetamide::CHEMBL353922 Coagulation factor X Homo sapiens >2500 ChEMBL 10.1016/s0960-894x(99)00102-x 10.7270/Q2NS0T3Q 10206557 Reiner, JE; Lim-Wilby, MS; Brunck, TK; Ha-Uong, T; Goldman, EA; Abelman, MA; Nutt, RF; Semple, JE; Tamura, SY Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50076070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50076070&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9983043 103969066 CHEMBL353922 ZINC27989093 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134614 NC(=N)c1ccc(Oc2cccc(Oc3ccccc3C(N)=N)n2)cc1 InChI=1S/C19H17N5O2/c20-18(21)12-8-10-13(11-9-12)25-16-6-3-7-17(24-16)26-15-5-2-1-4-14(15)19(22)23/h1-11H,(H3,20,21)(H3,22,23) OWCKBLKNIPDMGZ-UHFFFAOYSA-N 50077165 2-{6-[4-amino(imino)methylphenoxy]-2-pyridyloxy}phenyl-iminomethanamine::CHEMBL51824 Coagulation factor X Homo sapiens 130 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077165&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44294202 103969973 CHEMBL51824 ZINC29471504 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134616 NC(=N)c1ccc(\C=C2/CCCC\C(=C/c3ccc(cc3)C(N)=N)C2=O)cc1 InChI=1S/C23H24N4O/c24-22(25)17-9-5-15(6-10-17)13-19-3-1-2-4-20(21(19)28)14-16-7-11-18(12-8-16)23(26)27/h5-14H,1-4H2,(H3,24,25)(H3,26,27)/b19-13+,20-14+ BGRKMKHJBDYTGS-IWGRKNQJSA-N 50066614 (E,E)-2,7-Bis(4-amidinobenzylidine)cycloheptan-1-one::2,7-di[1-[4-amino(imino)methylphenyl]-(E)-methylidene]-1-cycloheptanone::CHEMBL48233 Coagulation factor X Homo sapiens 0.66 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066614&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 639391 103961234 CHEMBL48233 ZINC38141175 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134617 NC(=N)c1cccc(Oc2ccc(NC(=O)Nc3ccccc3)c(Oc3cccc(c3)C(N)=N)n2)c1 InChI=1S/C26H23N7O3/c27-23(28)16-6-4-10-19(14-16)35-22-13-12-21(32-26(34)31-18-8-2-1-3-9-18)25(33-22)36-20-11-5-7-17(15-20)24(29)30/h1-15H,(H3,27,28)(H3,29,30)(H2,31,32,34) APLBUSRQDBJWAR-UHFFFAOYSA-N 50077170 2,6-di[3-amino-phenyl carboxamide-(imino)methylphenoxy]-3-pyridinamine::CHEMBL300622 Coagulation factor X Homo sapiens 62 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077170&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10838473 103969978 CHEMBL300622 ZINC13797401 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134618 NC(=N)c1cccc(Oc2cc(cc(Oc3cccc(c3)C(N)=N)n2)C(N)=O)c1 InChI=1S/C20H18N6O3/c21-18(22)11-3-1-5-14(7-11)28-16-9-13(20(25)27)10-17(26-16)29-15-6-2-4-12(8-15)19(23)24/h1-10H,(H3,21,22)(H3,23,24)(H2,25,27) BCFJMQFQKRGACT-UHFFFAOYSA-N 50077168 2,6-Bis-(3-carbamimidoyl-phenoxy)-isonicotinamide::CHEMBL296532 Coagulation factor X Homo sapiens 42 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077168&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10786604 103969976 CHEMBL296532 ZINC13797436 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134623 NC(=N)c1cccc(Oc2cc(cc(Oc3cccc(c3)C(N)=N)n2)C(O)=O)c1 InChI=1S/C20H17N5O4/c21-18(22)11-3-1-5-14(7-11)28-16-9-13(20(26)27)10-17(25-16)29-15-6-2-4-12(8-15)19(23)24/h1-10H,(H3,21,22)(H3,23,24)(H,26,27) NKMYAABWJWHHLH-UHFFFAOYSA-N 50066620 2,6-Bis-(3-carbamimidoyl-phenoxy)-isonicotinic acid::CHEMBL48604 Coagulation factor X Homo sapiens 59 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066620&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10715476 103961240 CHEMBL48604 ZINC13474062 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134625 NC(=N)c1cccc(OC2N=C(CNC2=O)Oc2cccc(n2)C(N)=N)c1 InChI=1S/C17H17N7O3/c18-14(19)9-3-1-4-10(7-9)26-17-16(25)22-8-13(24-17)27-12-6-2-5-11(23-12)15(20)21/h1-7,17H,8H2,(H3,18,19)(H3,20,21)(H,22,25) PWTAVJTYNIFGIS-UHFFFAOYSA-N 50077174 6-[6-(3-Carbamimidoyl-phenoxy)-5-oxo-1,2,5,6-tetrahydro-pyrazin-2-yloxy]-pyridine-2-carboxamidine::CHEMBL50961 Coagulation factor X Homo sapiens 190 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50077174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50077174&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44294144 103969982 CHEMBL50961 ZINC36140590 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50134628 NC(=N)c1ccc(Oc2cccc(Oc3ccc(cc3)C(N)=N)n2)cc1 InChI=1S/C19H17N5O2/c20-18(21)12-4-8-14(9-5-12)25-16-2-1-3-17(24-16)26-15-10-6-13(7-11-15)19(22)23/h1-11H,(H3,20,21)(H3,22,23) VATCDKFGSBVBMX-UHFFFAOYSA-N 50066618 4-{6-[4-amino(imino)methylphenoxy]-2-pyridyloxy}phenyl-iminomethanamine::CHEMBL298415 Coagulation factor X Homo sapiens 400 ChEMBL 10.1021/jm980667k 10.7270/Q2FX78NF 10346927 Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Berlex Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066618&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9997816 103961238 CHEMBL298415 ZINC13781058 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137493 CCN(CC)C(=O)c1cccc(c1)-c1ccc2C[C@H]3[C@@H]([C@@H](CCCCC(N)=N)C(=O)N3COC(C)=O)c2c1 InChI=1S/C30H38N4O4/c1-4-33(5-2)29(36)23-10-8-9-20(15-23)21-13-14-22-17-26-28(25(22)16-21)24(11-6-7-12-27(31)32)30(37)34(26)18-38-19(3)35/h8-10,13-16,24,26,28H,4-7,11-12,17-18H2,1-3H3,(H3,31,32)/t24-,26+,28+/m1/s1 GKIHXHVLEWLVGT-XDIPAPSNSA-N 50078545 Acetic acid (3R,3aS,8aS)-3-(4-carbamimidoyl-butyl)-5-(3-diethylcarbamoyl-phenyl)-2-oxo-3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]pyrrol-1-ylmethyl ester::CHEMBL46993 Coagulation factor X Homo sapiens 14000 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078545&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290542 103971091 CHEMBL46993 ZINC29401793 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137495 CCN(CC)C(=O)c1cccc(c1)-c1ccc2C[C@H]3[C@@H]([C@@H](CCCCC(N)=N)C(=O)N3CCCCCc3ccccc3)c2c1 InChI=1S/C38H48N4O2/c1-3-41(4-2)37(43)31-18-13-17-28(24-31)29-21-22-30-26-34-36(33(30)25-29)32(19-10-11-20-35(39)40)38(44)42(34)23-12-6-9-16-27-14-7-5-8-15-27/h5,7-8,13-15,17-18,21-22,24-25,32,34,36H,3-4,6,9-12,16,19-20,23,26H2,1-2H3,(H3,39,40)/t32-,34+,36+/m1/s1 KKVROIJUGNLEGV-YFKWQYMLSA-N 50078547 3-[(3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-2-oxo-1-(5-phenyl-pentyl)-1,2,3,3a,8,8a-hexahydro-indeno[2,1-b]pyrrol-5-yl]-N,N-diethyl-benzamide::CHEMBL296972 Coagulation factor X Homo sapiens >50000 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078547&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290518 103971093 CHEMBL296972 ZINC29399314 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137496 CCN(CC)C(=O)c1cccc(c1)-c1ccc2[C@H]3[C@H](Cc2c1)N(CCCCCc1ccccc1)C(=O)[C@@H]3CCCCC(N)=N InChI=1S/C38H48N4O2/c1-3-41(4-2)37(43)30-18-13-17-28(24-30)29-21-22-32-31(25-29)26-34-36(32)33(19-10-11-20-35(39)40)38(44)42(34)23-12-6-9-16-27-14-7-5-8-15-27/h5,7-8,13-15,17-18,21-22,24-25,33-34,36H,3-4,6,9-12,16,19-20,23,26H2,1-2H3,(H3,39,40)/t33-,34+,36-/m1/s1 ZIDHHXAACGJDRP-SHXLRKJTSA-N 50078548 3-[(3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-2-oxo-1-(5-phenyl-pentyl)-1,2,3,3a,8,8a-hexahydro-indeno[2,1-b]pyrrol-6-yl]-N,N-diethyl-benzamide::CHEMBL44891 Coagulation factor X Homo sapiens 26000 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078548&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290556 103971094 CHEMBL44891 ZINC29402485 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137498 COC(=O)CN1[C@H]2Cc3ccccc3[C@@H]2[C@@H](CCCCC(N)=N)C1=O InChI=1S/C19H25N3O3/c1-25-17(23)11-22-15-10-12-6-2-3-7-13(12)18(15)14(19(22)24)8-4-5-9-16(20)21/h2-3,6-7,14-15,18H,4-5,8-11H2,1H3,(H3,20,21)/t14-,15+,18-/m1/s1 PJNIJOHEXAJXHR-RVKKMQEKSA-N 50078550 CHEMBL295211::[(3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-2-oxo-3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]pyrrol-1-yl]-acetic acid methyl ester Coagulation factor X Homo sapiens >200000 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078550&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290379 103971096 CHEMBL295211 ZINC29398725 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137500 CCNC(=O)N1[C@H]2Cc3ccc(cc3[C@@H]2[C@@H](CCCCC(N)=N)C1=O)-c1cccc(c1)C(=O)N(CC)CC InChI=1S/C30H39N5O3/c1-4-33-30(38)35-25-18-21-15-14-20(19-10-9-11-22(16-19)28(36)34(5-2)6-3)17-24(21)27(25)23(29(35)37)12-7-8-13-26(31)32/h9-11,14-17,23,25,27H,4-8,12-13,18H2,1-3H3,(H3,31,32)(H,33,38)/t23-,25+,27+/m1/s1 REKIMMLUXVOHRM-NIYJGHKDSA-N 50078546 (3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-5-(3-diethylcarbamoyl-phenyl)-2-oxo-3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]pyrrole-1-carboxylic acid ethylamide::CHEMBL45032 Coagulation factor X Homo sapiens >100000 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078546&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290377 103971092 CHEMBL45032 ZINC29402600 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137507 CCOP(=O)(OCC)N1[C@H]2Cc3cc(ccc3[C@@H]2[C@@H](CCCCC(N)=N)C1=O)-c1cccc(c1)C(=O)N(CC)CC InChI=1S/C31H43N4O5P/c1-5-34(6-2)30(36)23-13-11-12-21(18-23)22-16-17-25-24(19-22)20-27-29(25)26(14-9-10-15-28(32)33)31(37)35(27)41(38,39-7-3)40-8-4/h11-13,16-19,26-27,29H,5-10,14-15,20H2,1-4H3,(H3,32,33)/t26-,27+,29-/m1/s1 GNOYEZXDZMTHAR-IUAQSZDVSA-N 50078551 CHEMBL46365::[(3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethylcarbamoyl-phenyl)-2-oxo-3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]pyrrol-1-yl]-phosphonic acid diethyl ester Coagulation factor X Homo sapiens 20000 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078551&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290516 103971097 CHEMBL46365 ZINC29399526 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137510 CCN(CC)C(=O)c1cccc(c1)-c1ccc2C[C@H]3[C@@H]([C@@H](CCCCC(N)=N)C(=O)N3C(=O)N(C)C)c2c1 InChI=1S/C30H39N5O3/c1-5-34(6-2)28(36)22-11-9-10-19(16-22)20-14-15-21-18-25-27(24(21)17-20)23(12-7-8-13-26(31)32)29(37)35(25)30(38)33(3)4/h9-11,14-17,23,25,27H,5-8,12-13,18H2,1-4H3,(H3,31,32)/t23-,25+,27+/m1/s1 DUMSRSLPMAIPHR-NIYJGHKDSA-N 50078555 (3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-5-(3-diethylcarbamoyl-phenyl)-2-oxo-3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]pyrrole-1-carboxylic acid dimethylamide::CHEMBL47143 Coagulation factor X Homo sapiens >20000 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078555&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290376 103971101 CHEMBL47143 ZINC29402596 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137511 CCN(CC)C(=O)c1cccc(c1)-c1ccc2C[C@H]3[C@@H]([C@@H](CCCCC(N)=N)C(=O)N3C(=O)OCCCc3ccccc3)c2c1 InChI=1S/C37H44N4O4/c1-3-40(4-2)35(42)29-16-10-15-26(22-29)27-19-20-28-24-32-34(31(28)23-27)30(17-8-9-18-33(38)39)36(43)41(32)37(44)45-21-11-14-25-12-6-5-7-13-25/h5-7,10,12-13,15-16,19-20,22-23,30,32,34H,3-4,8-9,11,14,17-18,21,24H2,1-2H3,(H3,38,39)/t30-,32+,34+/m1/s1 SXBVIWSLSYULRK-LLISZCHOSA-N 50078552 (3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-5-(3-diethylcarbamoyl-phenyl)-2-oxo-3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]pyrrole-1-carboxylic acid 3-phenyl-propyl ester::CHEMBL47102 Coagulation factor X Homo sapiens 3700 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078552&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290520 103971098 CHEMBL47102 ZINC29398722 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137512 CCN(CC)C(=O)c1cccc(c1)-c1ccc2C[C@H]3[C@@H]([C@@H](CCCCC(N)=N)C(=O)N3S(=O)(=O)c3ccccc3)c2c1 InChI=1S/C33H38N4O4S/c1-3-36(4-2)32(38)25-12-10-11-22(19-25)23-17-18-24-21-29-31(28(24)20-23)27(15-8-9-16-30(34)35)33(39)37(29)42(40,41)26-13-6-5-7-14-26/h5-7,10-14,17-20,27,29,31H,3-4,8-9,15-16,21H2,1-2H3,(H3,34,35)/t27-,29+,31+/m1/s1 UWMOBFHBRYCOPF-QKMMQOFESA-N 50078544 3-[(3R,3aS,8aS)-1-Benzenesulfonyl-3-(4-carbamimidoyl-butyl)-2-oxo-1,2,3,3a,8,8a-hexahydro-indeno[2,1-b]pyrrol-5-yl]-N,N-diethyl-benzamide::CHEMBL297169 Coagulation factor X Homo sapiens 74.0 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078544&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290530 103971090 CHEMBL297169 ZINC29400866 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137516 NC(=N)CCCC[C@@H]1[C@@H]2[C@H](Cc3ccccc23)N(CCCCCc2ccccc2)C1=O InChI=1S/C27H35N3O/c28-25(29)17-9-8-16-23-26-22-15-7-6-14-21(22)19-24(26)30(27(23)31)18-10-2-5-13-20-11-3-1-4-12-20/h1,3-4,6-7,11-12,14-15,23-24,26H,2,5,8-10,13,16-19H2,(H3,28,29)/t23-,24+,26-/m1/s1 QKUOYYOPSMNOBQ-RMTZWNOUSA-N 50078558 5-[(3R,3aS,8aS)-2-Oxo-1-(5-phenyl-pentyl)-1,2,3,3a,8,8a-hexahydro-indeno[2,1-b]pyrrol-3-yl]-pentanamidine::CHEMBL46923 Coagulation factor X Homo sapiens >100000 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078558&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290502 103971104 CHEMBL46923 ZINC29399909 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137517 NC(=N)CCCC[C@@H]1[C@@H]2[C@H](Cc3ccccc23)NC1=O InChI=1S/C16H21N3O/c17-14(18)8-4-3-7-12-15-11-6-2-1-5-10(11)9-13(15)19-16(12)20/h1-2,5-6,12-13,15H,3-4,7-9H2,(H3,17,18)(H,19,20)/t12-,13+,15-/m1/s1 CSQZHNJOGJLEFX-VNHYZAJKSA-N 50078559 5-((3R,3aS,8aS)-2-Oxo-1,2,3,3a,8,8a-hexahydro-indeno[2,1-b]pyrrol-3-yl)-pentanamidine::CHEMBL46649 Coagulation factor X Homo sapiens >200000 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078559&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290501 103971105 CHEMBL46649 ZINC29400860 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137519 CCN(CC)C(=O)c1cccc(c1)-c1ccc2[C@H]3[C@H](Cc2c1)N(C(=O)OCCCc1ccccc1)C(=O)[C@@H]3CCCCC(N)=N InChI=1S/C37H44N4O4/c1-3-40(4-2)35(42)28-16-10-15-26(22-28)27-19-20-30-29(23-27)24-32-34(30)31(17-8-9-18-33(38)39)36(43)41(32)37(44)45-21-11-14-25-12-6-5-7-13-25/h5-7,10,12-13,15-16,19-20,22-23,31-32,34H,3-4,8-9,11,14,17-18,21,24H2,1-2H3,(H3,38,39)/t31-,32+,34-/m1/s1 OJRKQKMPNJUKML-HWIYEDSRSA-N 50078557 (3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethylcarbamoyl-phenyl)-2-oxo-3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]pyrrole-1-carboxylic acid 3-phenyl-propyl ester::CHEMBL44710 Coagulation factor X Homo sapiens 3600 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078557&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290378 103971103 CHEMBL44710 ZINC29402602 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137522 CCN(CC)C(=O)c1cccc(c1)-c1ccc2C[C@H]3[C@@H]([C@@H](CCCCC(N)=N)C(=O)N3C(=O)CC)c2c1 InChI=1S/C30H38N4O3/c1-4-27(35)34-25-18-21-15-14-20(19-10-9-11-22(16-19)29(36)33(5-2)6-3)17-24(21)28(25)23(30(34)37)12-7-8-13-26(31)32/h9-11,14-17,23,25,28H,4-8,12-13,18H2,1-3H3,(H3,31,32)/t23-,25+,28+/m1/s1 AJWHFWHDAUENOT-CRRLPVGBSA-N 50078556 3-[(3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-2-oxo-1-propionyl-1,2,3,3a,8,8a-hexahydro-indeno[2,1-b]pyrrol-5-yl]-N,N-diethyl-benzamide::CHEMBL47074 Coagulation factor X Homo sapiens 9900 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078556&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290361 103971102 CHEMBL47074 ZINC29398670 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137523 CCN(CC)C(=O)c1cccc(c1)-c1ccc2C[C@H]3[C@@H]([C@@H](CCCCC(N)=N)C(=O)N3C(=O)OC)c2c1 InChI=1S/C29H36N4O4/c1-4-32(5-2)27(34)21-10-8-9-18(15-21)19-13-14-20-17-24-26(23(20)16-19)22(11-6-7-12-25(30)31)28(35)33(24)29(36)37-3/h8-10,13-16,22,24,26H,4-7,11-12,17H2,1-3H3,(H3,30,31)/t22-,24+,26+/m1/s1 UJKVEAALZSDOIJ-CWDLOFLHSA-N 50078553 (3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-5-(3-diethylcarbamoyl-phenyl)-2-oxo-3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]pyrrole-1-carboxylic acid methyl ester::CHEMBL295886 Coagulation factor X Homo sapiens 2200 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078553&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290519 103971099 CHEMBL295886 ZINC29398719 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137532 CCNC(=O)N1[C@H]2Cc3cc(ccc3[C@@H]2[C@@H](CCCCC(N)=N)C1=O)-c1cccc(c1)C(=O)N(CC)CC InChI=1S/C30H39N5O3/c1-4-33-30(38)35-25-18-22-17-20(19-10-9-11-21(16-19)28(36)34(5-2)6-3)14-15-23(22)27(25)24(29(35)37)12-7-8-13-26(31)32/h9-11,14-17,24-25,27H,4-8,12-13,18H2,1-3H3,(H3,31,32)(H,33,38)/t24-,25+,27-/m1/s1 JVDFVNJPTQHXBV-CMTIAEDTSA-N 50078549 (3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethylcarbamoyl-phenyl)-2-oxo-3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]pyrrole-1-carboxylic acid ethylamide::CHEMBL296764 Coagulation factor X Homo sapiens 5600 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078549&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290529 103971095 CHEMBL296764 ZINC29400864 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50137535 CCN(CC)C(=O)c1cccc(c1)-c1ccc2[C@H]3[C@H](Cc2c1)N(C(=O)OC)C(=O)[C@@H]3CCCCC(N)=N InChI=1S/C29H36N4O4/c1-4-32(5-2)27(34)20-10-8-9-18(15-20)19-13-14-22-21(16-19)17-24-26(22)23(11-6-7-12-25(30)31)28(35)33(24)29(36)37-3/h8-10,13-16,23-24,26H,4-7,11-12,17H2,1-3H3,(H3,30,31)/t23-,24+,26-/m1/s1 ZVZKYABQRFIIAV-RMTZWNOUSA-N 50078554 (3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethylcarbamoyl-phenyl)-2-oxo-3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]pyrrole-1-carboxylic acid methyl ester::CHEMBL46845 Coagulation factor X Homo sapiens 120 ChEMBL 10.1016/s0960-894x(99)00244-9 10.7270/Q2VT1R8Q 10397495 Pass, M; Abu-Rabie, S; Baxter, A; Conroy, R; Coote, SJ; Craven, AP; Finch, H; Hindley, S; Kelly, HA; Lowdon, AW; McDonald, E; Mitchell, WL; Pegg, NA; Procopiou, PA; Ramsden, NG; Thomas, R; Walker, DA; Watson, NS; Jhoti, H; Mooney, CJ; Tang, CM; Thomas, PJ; Parry, S; Patel, C Glaxo Wellcome Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078554&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44290555 103971100 CHEMBL46845 ZINC29403388 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138683 CCOCC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C26H27N5O5S/c1-2-35-16-26(15-22(31-36-26)18-6-5-7-19(14-18)24(27)28)25(32)30-20-12-10-17(11-13-20)21-8-3-4-9-23(21)37(29,33)34/h3-14H,2,15-16H2,1H3,(H3,27,28)(H,30,32)(H2,29,33,34) BYLDDEKOPBHCIK-UHFFFAOYSA-N 50079228 3-(3-Carbamimidoyl-phenyl)-5-ethoxymethyl-4,5-dihydro-isoxazole-5-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL1184021::CHEMBL328582 Coagulation factor X Homo sapiens 3.5 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079228&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10841758 103971541 CHEMBL328582CHEMBL1184021 ZINC13799330 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138685 NC(=N)c1cccc(c1)C1=NOC(Cn2cnnn2)(C1)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C25H23N9O4S/c26-23(27)18-5-3-4-17(12-18)21-13-25(38-31-21,14-34-15-29-32-33-34)24(35)30-19-10-8-16(9-11-19)20-6-1-2-7-22(20)39(28,36)37/h1-12,15H,13-14H2,(H3,26,27)(H,30,35)(H2,28,36,37) FJIBYMWCVCRSIO-UHFFFAOYSA-N 50079236 3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL159418::CHEMBL328069 Coagulation factor X Homo sapiens 1.6 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079236&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9917705 103971549 CHEMBL328069CHEMBL159418 ZINC14096406 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138686 CCS(=O)(=O)CC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ncc(cn1)-c1ccccc1S(N)(=O)=O InChI=1S/C24H25N7O6S2/c1-2-38(33,34)14-24(11-19(31-37-24)15-6-5-7-16(10-15)21(25)26)22(32)30-23-28-12-17(13-29-23)18-8-3-4-9-20(18)39(27,35)36/h3-10,12-13H,2,11,14H2,1H3,(H3,25,26)(H2,27,35,36)(H,28,29,30,32) WVAOHMVBVSDJQO-UHFFFAOYSA-N 50079233 3-(3-Carbamimidoyl-phenyl)-5-ethanesulfonylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyrimidin-2-yl]-amide; TFA::CHEMBL328805 Coagulation factor X Homo sapiens 5.3 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079233&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11802721 103971546 CHEMBL328805 ZINC26662742 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138689 NC(=N)c1cccc(c1)C1=NOC(Cn2ncnn2)(C1)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C25H23N9O4S/c26-23(27)18-5-3-4-17(12-18)21-13-25(38-32-21,14-34-30-15-29-33-34)24(35)31-19-10-8-16(9-11-19)20-6-1-2-7-22(20)39(28,36)37/h1-12,15H,13-14H2,(H3,26,27)(H,31,35)(H2,28,36,37) MSQXYLXRTPWVQG-UHFFFAOYSA-N 50079235 3-(3-Carbamimidoyl-phenyl)-5-tetrazol-2-ylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL91999 Coagulation factor X Homo sapiens 1.6 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079235&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10770621 103971548 CHEMBL91999 ZINC26659092 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138692 NC(=N)c1cccc(c1)C1=NOC(CC(O)=O)(C1)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C25H23N5O6S/c26-23(27)17-5-3-4-16(12-17)20-13-25(36-30-20,14-22(31)32)24(33)29-18-10-8-15(9-11-18)19-6-1-2-7-21(19)37(28,34)35/h1-12H,13-14H2,(H3,26,27)(H,29,33)(H,31,32)(H2,28,34,35) GDEOTOXKKWDFKD-UHFFFAOYSA-N 50079239 CHEMBL316318::[3-(3-Carbamimidoyl-phenyl)-5-(2'-sulfamoyl-biphenyl-4-ylcarbamoyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid; TFA Coagulation factor X Homo sapiens 20 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079239&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21218732 103971552 CHEMBL316318 ZINC13799306 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138697 COCCC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C26H27N5O5S/c1-35-14-13-26(16-22(31-36-26)18-5-4-6-19(15-18)24(27)28)25(32)30-20-11-9-17(10-12-20)21-7-2-3-8-23(21)37(29,33)34/h2-12,15H,13-14,16H2,1H3,(H3,27,28)(H,30,32)(H2,29,33,34) KUXGIJZKHAPBOL-UHFFFAOYSA-N 50079231 3-(3-Carbamimidoyl-phenyl)-5-(2-methoxy-ethyl)-4,5-dihydro-isoxazole-5-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL94052 Coagulation factor X Homo sapiens 5 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079231&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10697320 103971544 CHEMBL94052 ZINC13799314 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138701 CCSCC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ncc(cn1)-c1ccccc1S(N)(=O)=O InChI=1S/C24H25N7O4S2/c1-2-36-14-24(11-19(31-35-24)15-6-5-7-16(10-15)21(25)26)22(32)30-23-28-12-17(13-29-23)18-8-3-4-9-20(18)37(27,33)34/h3-10,12-13H,2,11,14H2,1H3,(H3,25,26)(H2,27,33,34)(H,28,29,30,32) QHYSKFYMFDJSJU-UHFFFAOYSA-N 50079243 3-(3-Carbamimidoyl-phenyl)-5-ethylsulfanylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyrimidin-2-yl]-amide; TFA::CHEMBL316311 Coagulation factor X Homo sapiens 2.4 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079243&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10628066 103971556 CHEMBL316311 ZINC26660122 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138706 COC(=O)CC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ncc(cn1)-c1ccccc1S(N)(=O)=O InChI=1S/C24H23N7O6S/c1-36-20(32)11-24(10-18(31-37-24)14-5-4-6-15(9-14)21(25)26)22(33)30-23-28-12-16(13-29-23)17-7-2-3-8-19(17)38(27,34)35/h2-9,12-13H,10-11H2,1H3,(H3,25,26)(H2,27,34,35)(H,28,29,30,33) LAUGVCLUYPMNEP-UHFFFAOYSA-N 50079222 CHEMBL327213::{3-(3-Carbamimidoyl-phenyl)-5-[5-(2-sulfamoyl-phenyl)-pyrimidin-2-ylcarbamoyl]-4,5-dihydro-isoxazol-5-yl}-acetic acid methyl ester; TFA Coagulation factor X Homo sapiens 4.3 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079222&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9937032 103971535 CHEMBL327213 ZINC14114506 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138708 NC(=N)c1cccc(c1)C1=NOC(Cn2cncn2)(C1)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C26H24N8O4S/c27-24(28)19-5-3-4-18(12-19)22-13-26(38-33-22,14-34-16-30-15-31-34)25(35)32-20-10-8-17(9-11-20)21-6-1-2-7-23(21)39(29,36)37/h1-12,15-16H,13-14H2,(H3,27,28)(H,32,35)(H2,29,36,37) JIAYVDPPILTWKJ-UHFFFAOYSA-N 50079246 3-(3-Carbamimidoyl-phenyl)-5-[1,2,4]triazol-1-ylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL436684 Coagulation factor X Homo sapiens 1.7 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079246&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10770606 103971559 CHEMBL436684 ZINC26665372 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138710 CCCCOCC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C28H31N5O5S/c1-2-3-15-37-18-28(17-24(33-38-28)20-7-6-8-21(16-20)26(29)30)27(34)32-22-13-11-19(12-14-22)23-9-4-5-10-25(23)39(31,35)36/h4-14,16H,2-3,15,17-18H2,1H3,(H3,29,30)(H,32,34)(H2,31,35,36) WXUZEMMPZJCAKV-UHFFFAOYSA-N 50079234 5-Butoxymethyl-3-(3-carbamimidoyl-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL330284 Coagulation factor X Homo sapiens 13 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079234&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11802531 103971547 CHEMBL330284 ZINC26659105 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138711 NC(=N)c1cccc(c1)C1=NOC(C1)(C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O)C(F)(F)F InChI=1S/C24H20F3N5O4S/c25-24(26,27)23(13-19(32-36-23)15-4-3-5-16(12-15)21(28)29)22(33)31-17-10-8-14(9-11-17)18-6-1-2-7-20(18)37(30,34)35/h1-12H,13H2,(H3,28,29)(H,31,33)(H2,30,34,35) MFKRXTPHKUWERL-UHFFFAOYSA-N 50079237 3-(3-Carbamimidoyl-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole-5-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL445678 Coagulation factor X Homo sapiens 23 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079237&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10556167 103971550 CHEMBL445678 ZINC26665394 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138713 CC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C24H23N5O4S/c1-24(14-20(29-33-24)16-5-4-6-17(13-16)22(25)26)23(30)28-18-11-9-15(10-12-18)19-7-2-3-8-21(19)34(27,31)32/h2-13H,14H2,1H3,(H3,25,26)(H,28,30)(H2,27,31,32) WTULADZJJBGGRF-UHFFFAOYSA-N 50079247 3-(3-Carbamimidoyl-phenyl)-5-methyl-4,5-dihydro-isoxazole-5-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL330496::CHEMBL7967 Coagulation factor X Homo sapiens 11 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079247&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11801580 103971560 CHEMBL330496CHEMBL7967 ZINC13799339 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138714 CCOCC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ncc(cn1)-c1ccccc1S(N)(=O)=O InChI=1S/C24H25N7O5S/c1-2-35-14-24(11-19(31-36-24)15-6-5-7-16(10-15)21(25)26)22(32)30-23-28-12-17(13-29-23)18-8-3-4-9-20(18)37(27,33)34/h3-10,12-13H,2,11,14H2,1H3,(H3,25,26)(H2,27,33,34)(H,28,29,30,32) CAVVVGRCMBUNHS-UHFFFAOYSA-N 50079248 3-(3-Carbamimidoyl-phenyl)-5-ethoxymethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyrimidin-2-yl]-amide; TFA::CHEMBL328577 Coagulation factor X Homo sapiens 6.8 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079248&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10556085 103971561 CHEMBL328577 ZINC13799354 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138717 COC(=O)CC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cn1)-c1ccccc1S(N)(=O)=O InChI=1S/C25H24N6O6S/c1-36-22(32)13-25(12-19(31-37-25)15-5-4-6-16(11-15)23(26)27)24(33)30-21-10-9-17(14-29-21)18-7-2-3-8-20(18)38(28,34)35/h2-11,14H,12-13H2,1H3,(H3,26,27)(H2,28,34,35)(H,29,30,33) ZBAFGDZBJMAQPN-UHFFFAOYSA-N 50079211 CHEMBL327404::{3-(3-Carbamimidoyl-phenyl)-5-[5-(2-sulfamoyl-phenyl)-pyridin-2-ylcarbamoyl]-4,5-dihydro-isoxazol-5-yl}-acetic acid methyl ester; TFA Coagulation factor X Homo sapiens 2.3 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079211&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 11756961 103971524 CHEMBL327404 ZINC14114511 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138721 CCS(=O)(=O)CC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cn1)-c1ccccc1S(N)(=O)=O InChI=1S/C25H26N6O6S2/c1-2-38(33,34)15-25(13-20(31-37-25)16-6-5-7-17(12-16)23(26)27)24(32)30-22-11-10-18(14-29-22)19-8-3-4-9-21(19)39(28,35)36/h3-12,14H,2,13,15H2,1H3,(H3,26,27)(H2,28,35,36)(H,29,30,32) WYPLXKNPOOGKQB-UHFFFAOYSA-N 50079232 3-(3-Carbamimidoyl-phenyl)-5-ethanesulfonylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyridin-2-yl]-amide; TFA::CHEMBL93744 Coagulation factor X Homo sapiens 1.7 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079232&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10770845 103971545 CHEMBL93744 ZINC26658665 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138724 NC(=N)c1cccc(c1)C1=NOC(Cn2cnnn2)(C1)C(=O)Nc1ncc(cn1)-c1ccccc1S(N)(=O)=O InChI=1S/C23H21N11O4S/c24-20(25)15-5-3-4-14(8-15)18-9-23(38-31-18,12-34-13-29-32-33-34)21(35)30-22-27-10-16(11-28-22)17-6-1-2-7-19(17)39(26,36)37/h1-8,10-11,13H,9,12H2,(H3,24,25)(H2,26,36,37)(H,27,28,30,35) IGNSBDLQAZHCTR-UHFFFAOYSA-N 50079253 3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyrimidin-2-yl]-amide; TFA::CHEMBL1183989::CHEMBL327331 Coagulation factor X Homo sapiens 1.3 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079253&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10580222 103971566 CHEMBL327331CHEMBL1183989 ZINC26662306 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138727 COCC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C25H25N5O5S/c1-34-15-25(14-21(30-35-25)17-5-4-6-18(13-17)23(26)27)24(31)29-19-11-9-16(10-12-19)20-7-2-3-8-22(20)36(28,32)33/h2-13H,14-15H2,1H3,(H3,26,27)(H,29,31)(H2,28,32,33) CSZCUWDVIVOGJP-UHFFFAOYSA-N 50079252 3-(3-Carbamimidoyl-phenyl)-5-methoxymethyl-4,5-dihydro-isoxazole-5-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL328298::CHEMBL350499 Coagulation factor X Homo sapiens 3.4 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079252&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10051960 103971565 CHEMBL350499CHEMBL328298 ZINC13799322 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138728 COCC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cn1)-c1ccccc1S(N)(=O)=O InChI=1S/C24H24N6O5S/c1-34-14-24(12-19(30-35-24)15-5-4-6-16(11-15)22(25)26)23(31)29-21-10-9-17(13-28-21)18-7-2-3-8-20(18)36(27,32)33/h2-11,13H,12,14H2,1H3,(H3,25,26)(H2,27,32,33)(H,28,29,31) DEKNGEPVVQKQJB-UHFFFAOYSA-N 50079249 3-(3-Carbamimidoyl-phenyl)-5-methoxymethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyridin-2-yl]-amide; TFA::CHEMBL92909 Coagulation factor X Homo sapiens 2.5 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079249&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10436294 103971562 CHEMBL92909 ZINC13799364 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138729 CCS(=O)(=O)CC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C26H27N5O6S2/c1-2-38(33,34)16-26(15-22(31-37-26)18-6-5-7-19(14-18)24(27)28)25(32)30-20-12-10-17(11-13-20)21-8-3-4-9-23(21)39(29,35)36/h3-14H,2,15-16H2,1H3,(H3,27,28)(H,30,32)(H2,29,35,36) JAAHCKRSVQLMQH-UHFFFAOYSA-N 50079242 3-(3-Carbamimidoyl-phenyl)-5-ethanesulfonylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL406295 Coagulation factor X Homo sapiens 3.5 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079242&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10580437 103971555 CHEMBL406295 ZINC26661955 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138735 COC(=O)CC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C26H25N5O6S/c1-36-23(32)15-26(14-21(31-37-26)17-5-4-6-18(13-17)24(27)28)25(33)30-19-11-9-16(10-12-19)20-7-2-3-8-22(20)38(29,34)35/h2-13H,14-15H2,1H3,(H3,27,28)(H,30,33)(H2,29,34,35) QMEXGOMLMAXBEB-UHFFFAOYSA-N 50072445 CHEMBL139063::CHEMBL279628::[3-(3-Carbamimidoyl-phenyl)-5-(2'-sulfamoyl-biphenyl-4-ylcarbamoyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid methyl ester; TFA Coagulation factor X Homo sapiens 6.3 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072445&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9936983 103966073 CHEMBL279628CHEMBL139063 ZINC14113515 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138744 CC(C)OCC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C27H29N5O5S/c1-17(2)36-16-27(15-23(32-37-27)19-6-5-7-20(14-19)25(28)29)26(33)31-21-12-10-18(11-13-21)22-8-3-4-9-24(22)38(30,34)35/h3-14,17H,15-16H2,1-2H3,(H3,28,29)(H,31,33)(H2,30,34,35) BJQLQULIQREYIS-UHFFFAOYSA-N 50079255 3-(3-Carbamimidoyl-phenyl)-5-isopropoxymethyl-4,5-dihydro-isoxazole-5-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL327473 Coagulation factor X Homo sapiens 4.3 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079255&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10556206 103971568 CHEMBL327473 ZINC26662568 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138748 CC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cn1)-c1ccccc1S(N)(=O)=O InChI=1S/C23H22N6O4S/c1-23(12-18(29-33-23)14-5-4-6-15(11-14)21(24)25)22(30)28-20-10-9-16(13-27-20)17-7-2-3-8-19(17)34(26,31)32/h2-11,13H,12H2,1H3,(H3,24,25)(H2,26,31,32)(H,27,28,30) OAHPPGDAFVCFGP-UHFFFAOYSA-N 50079229 3-(3-Carbamimidoyl-phenyl)-5-methyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyridin-2-yl]-amide; TFA::CHEMBL92609 Coagulation factor X Homo sapiens 4.1 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079229&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10769759 103971542 CHEMBL92609 ZINC13799358 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138751 NC(=N)c1cccc(c1)C1=NOC(Cn2cnnn2)(C1)C(=O)Nc1ccc(cc1Cl)-c1ccccc1S(N)(=O)=O InChI=1S/C25H22ClN9O4S/c26-19-11-15(18-6-1-2-7-22(18)40(29,37)38)8-9-20(19)31-24(36)25(13-35-14-30-33-34-35)12-21(32-39-25)16-4-3-5-17(10-16)23(27)28/h1-11,14H,12-13H2,(H3,27,28)(H,31,36)(H2,29,37,38) UXJUUBCVRGQKNE-UHFFFAOYSA-N 50079257 3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid (3-chloro-2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL323309 Coagulation factor X Homo sapiens 0.15 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079257&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10438196 103971570 CHEMBL323309 ZINC26669632 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138753 CNS(=O)(=O)c1ccccc1-c1ccc(NC(=O)C2(Cn3cnnn3)CC(=NO2)c2cccc(c2)C(N)=N)cc1 InChI=1S/C26H25N9O4S/c1-29-40(37,38)23-8-3-2-7-21(23)17-9-11-20(12-10-17)31-25(36)26(15-35-16-30-33-34-35)14-22(32-39-26)18-5-4-6-19(13-18)24(27)28/h2-13,16,29H,14-15H2,1H3,(H3,27,28)(H,31,36) CPMPNWOJBUGGMU-UHFFFAOYSA-N 50079251 3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid (2'-methylsulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL321530 Coagulation factor X Homo sapiens 0.92 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079251&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10723163 103971564 CHEMBL321530 ZINC26670820 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138759 CCSCC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cn1)-c1ccccc1S(N)(=O)=O InChI=1S/C25H26N6O4S2/c1-2-36-15-25(13-20(31-35-25)16-6-5-7-17(12-16)23(26)27)24(32)30-22-11-10-18(14-29-22)19-8-3-4-9-21(19)37(28,33)34/h3-12,14H,2,13,15H2,1H3,(H3,26,27)(H2,28,33,34)(H,29,30,32) QGKSOYNSHUQKSD-UHFFFAOYSA-N 50079258 3-(3-Carbamimidoyl-phenyl)-5-ethylsulfanylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyridin-2-yl]-amide; TFA::CHEMBL327201 Coagulation factor X Homo sapiens 2.2 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079258&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10651873 103971571 CHEMBL327201 ZINC26658677 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138763 CCCOCC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C27H29N5O5S/c1-2-14-36-17-27(16-23(32-37-27)19-6-5-7-20(15-19)25(28)29)26(33)31-21-12-10-18(11-13-21)22-8-3-4-9-24(22)38(30,34)35/h3-13,15H,2,14,16-17H2,1H3,(H3,28,29)(H,31,33)(H2,30,34,35) KNDRHFIIOXMOMD-UHFFFAOYSA-N 50079244 3-(3-Carbamimidoyl-phenyl)-5-propoxymethyl-4,5-dihydro-isoxazole-5-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL327403 Coagulation factor X Homo sapiens 2.9 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079244&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10770527 103971557 CHEMBL327403 ZINC26659117 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138767 CCOCC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cn1)-c1ccccc1S(N)(=O)=O InChI=1S/C25H26N6O5S/c1-2-35-15-25(13-20(31-36-25)16-6-5-7-17(12-16)23(26)27)24(32)30-22-11-10-18(14-29-22)19-8-3-4-9-21(19)37(28,33)34/h3-12,14H,2,13,15H2,1H3,(H3,26,27)(H2,28,33,34)(H,29,30,32) MJYHESARPKNXPY-UHFFFAOYSA-N 50079230 3-(3-Carbamimidoyl-phenyl)-5-ethoxymethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyridin-2-yl]-amide; TFA::CHEMBL1183796::CHEMBL318112 Coagulation factor X Homo sapiens 2.8 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079230&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10722747 103971543 CHEMBL318112CHEMBL1183796 ZINC13799369 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138780 COCC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ncc(cn1)-c1ccccc1S(N)(=O)=O InChI=1S/C23H23N7O5S/c1-34-13-23(10-18(30-35-23)14-5-4-6-15(9-14)20(24)25)21(31)29-22-27-11-16(12-28-22)17-7-2-3-8-19(17)36(26,32)33/h2-9,11-12H,10,13H2,1H3,(H3,24,25)(H2,26,32,33)(H,27,28,29,31) JQGBWYNJNSRMPN-UHFFFAOYSA-N 50079245 3-(3-Carbamimidoyl-phenyl)-5-methoxymethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyrimidin-2-yl]-amide; TFA::CHEMBL327405 Coagulation factor X Homo sapiens 9.9 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079245&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10817699 103971558 CHEMBL327405 ZINC13799347 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138781 Cc1cc(ccc1NC(=O)C1(Cn2cnnn2)CC(=NO1)c1cccc(c1)C(N)=N)-c1ccccc1S(N)(=O)=O InChI=1S/C26H25N9O4S/c1-16-11-17(20-7-2-3-8-23(20)40(29,37)38)9-10-21(16)31-25(36)26(14-35-15-30-33-34-35)13-22(32-39-26)18-5-4-6-19(12-18)24(27)28/h2-12,15H,13-14H2,1H3,(H3,27,28)(H,31,36)(H2,29,37,38) PHHWZEWSGHCFRK-UHFFFAOYSA-N 50079250 3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid (3-methyl-2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL329460 Coagulation factor X Homo sapiens 1 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079250&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10770773 103971563 CHEMBL329460 ZINC26666262 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138783 NC(=N)c1cccc(c1)C1=NOC(Cc2ccccc2)(C1)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C30H27N5O4S/c31-28(32)23-10-6-9-22(17-23)26-19-30(39-35-26,18-20-7-2-1-3-8-20)29(36)34-24-15-13-21(14-16-24)25-11-4-5-12-27(25)40(33,37)38/h1-17H,18-19H2,(H3,31,32)(H,34,36)(H2,33,37,38) LNSJQGHCYSQTRJ-UHFFFAOYSA-N 50079241 5-Benzyl-3-(3-carbamimidoyl-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL316070 Coagulation factor X Homo sapiens 8.5 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079241&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10794535 103971554 CHEMBL316070 ZINC26665384 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138790 NC(=N)c1cccc(c1)C1=NOC(C1)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C23H21N5O4S/c24-22(25)16-5-3-4-15(12-16)19-13-20(32-28-19)23(29)27-17-10-8-14(9-11-17)18-6-1-2-7-21(18)33(26,30)31/h1-12,20H,13H2,(H3,24,25)(H,27,29)(H2,26,30,31) SZLKLAYGGJRRDH-UHFFFAOYSA-N 50079259 3-(3-Carbamimidoyl-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL301729::CHEMBL92523 Coagulation factor X Homo sapiens 7.2 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079259&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10840933 103971572 CHEMBL301729CHEMBL92523 ZINC13489887 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138792 CCCNS(=O)(=O)c1ccccc1-c1ccc(NC(=O)C2(Cn3cnnn3)CC(=NO2)c2cccc(c2)C(N)=N)cc1 InChI=1S/C28H29N9O4S/c1-2-14-32-42(39,40)25-9-4-3-8-23(25)19-10-12-22(13-11-19)33-27(38)28(17-37-18-31-35-36-37)16-24(34-41-28)20-6-5-7-21(15-20)26(29)30/h3-13,15,18,32H,2,14,16-17H2,1H3,(H3,29,30)(H,33,38) HTDWCKNOXARIND-UHFFFAOYSA-N 50079254 3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid (2'-propylsulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL264626 Coagulation factor X Homo sapiens 2.1 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079254&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10604774 103971567 CHEMBL264626 ZINC26670550 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138797 CC(C)COCC1(CC(=NO1)c1cccc(c1)C(N)=N)C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O InChI=1S/C28H31N5O5S/c1-18(2)16-37-17-28(15-24(33-38-28)20-6-5-7-21(14-20)26(29)30)27(34)32-22-12-10-19(11-13-22)23-8-3-4-9-25(23)39(31,35)36/h3-14,18H,15-17H2,1-2H3,(H3,29,30)(H,32,34)(H2,31,35,36) BRDWSYKDGOVQJG-UHFFFAOYSA-N 50079256 3-(3-Carbamimidoyl-phenyl)-5-isobutoxymethyl-4,5-dihydro-isoxazole-5-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL328451 Coagulation factor X Homo sapiens 37 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079256&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44326243 103971569 CHEMBL328451 ZINC26658709 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138798 NC(=N)c1cccc(c1)C1=NOC(Cn2cnnn2)(C1)C(=O)Nc1ccc(cc1F)-c1ccccc1S(N)(=O)=O InChI=1S/C25H22FN9O4S/c26-19-11-15(18-6-1-2-7-22(18)40(29,37)38)8-9-20(19)31-24(36)25(13-35-14-30-33-34-35)12-21(32-39-25)16-4-3-5-17(10-16)23(27)28/h1-11,14H,12-13H2,(H3,27,28)(H,31,36)(H2,29,37,38) RHFVBAXARQYYHX-UHFFFAOYSA-N 50079238 3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid (3-fluoro-2'-sulfamoyl-biphenyl-4-yl)-amide; TFA::CHEMBL323310 Coagulation factor X Homo sapiens 0.44 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079238&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10580396 103971551 CHEMBL323310 ZINC26669644 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50138799 NC(=N)c1cccc(c1)C1=NOC(Cn2cnnn2)(C1)C(=O)Nc1ccc(cn1)-c1ccccc1S(N)(=O)=O InChI=1S/C24H22N10O4S/c25-22(26)16-5-3-4-15(10-16)19-11-24(38-31-19,13-34-14-29-32-33-34)23(35)30-21-9-8-17(12-28-21)18-6-1-2-7-20(18)39(27,36)37/h1-10,12,14H,11,13H2,(H3,25,26)(H2,27,36,37)(H,28,30,35) NWIZWPMWIKFVDY-UHFFFAOYSA-N 50079240 3-(3-Carbamimidoyl-phenyl)-5-tetrazol-1-ylmethyl-4,5-dihydro-isoxazole-5-carboxylic acid [5-(2-sulfamoyl-phenyl)-pyridin-2-yl]-amide; TFA::CHEMBL7651::CHEMBL93210 Coagulation factor X Homo sapiens 0.17 ChEMBL 10.1021/jm980406a 10.7270/Q28W3CHG 10425087 Quan, ML; Ellis, CD; Liauw, AY; Alexander, RS; Knabb, RM; Lam, G; Wright, MR; Wong, PC; Wexler, RR DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079240&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10794450 103971553 CHEMBL7651CHEMBL93210 ZINC14096405 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142138 NC(=N)N1CCC[C@H](NC(=O)CN2C(=O)C(Cc3ccccc23)NS(=O)(=O)Cc2ccccc2)C1O InChI=1S/C24H30N6O5S/c25-24(26)29-12-6-10-18(22(29)32)27-21(31)14-30-20-11-5-4-9-17(20)13-19(23(30)33)28-36(34,35)15-16-7-2-1-3-8-16/h1-5,7-9,11,18-19,22,28,32H,6,10,12-15H2,(H3,25,26)(H,27,31)/t18-,19?,22?/m0/s1 GYZAJGLGNWNLGL-PGFLUOATSA-N 50081093 CHEMBL88079::N-((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-(2-oxo-3-phenylmethanesulfonylamino-3,4-dihydro-2H-quinolin-1-yl)-acetamide; TFA Coagulation factor X Homo sapiens >2500 ChEMBL 10.1016/s0960-894x(99)00417-5 10.7270/Q26M361R 10498211 Tamura, SY; Goldman, EA; Bergum, PW; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081093&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 15534822 103981153 CHEMBL88079 ZINC36107595 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142141 COc1ccc2N(CC(=O)N[C@H]3CCCN(C3O)C(N)=N)C(=O)[C@H](CCc2c1)NS(=O)(=O)c1ccc2ccccc2c1 InChI=1S/C29H34N6O6S/c1-41-21-10-13-25-20(15-21)9-12-24(33-42(39,40)22-11-8-18-5-2-3-6-19(18)16-22)28(38)35(25)17-26(36)32-23-7-4-14-34(27(23)37)29(30)31/h2-3,5-6,8,10-11,13,15-16,23-24,27,33,37H,4,7,9,12,14,17H2,1H3,(H3,30,31)(H,32,36)/t23-,24-,27?/m0/s1 LKXWXHDZJGJXKR-HFKGTQBBSA-N 50081088 CHEMBL316213::N-((S)-1-Carbamimidoyl-2-hydroxy-piperidin-3-yl)-2-[(S)-7-methoxy-3-(naphthalene-2-sulfonylamino)-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl]-acetamide; TFA Coagulation factor X Homo sapiens 19 ChEMBL 10.1016/s0960-894x(99)00417-5 10.7270/Q26M361R 10498211 Tamura, SY; Goldman, EA; Bergum, PW; Semple, JE Corvas International Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081088&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44320752 103981148 CHEMBL316213 ZINC26575323 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142526 Cc1c(F)c(Oc2cccc(CN)c2)cc(Oc2cccc(c2)C(N)=N)c1F InChI=1S/C21H19F2N3O2/c1-12-19(22)17(27-15-6-2-4-13(8-15)11-24)10-18(20(12)23)28-16-7-3-5-14(9-16)21(25)26/h2-10H,11,24H2,1H3,(H3,25,26) VPUTUVHMDQSNDQ-UHFFFAOYSA-N 50081364 3-[5-(3-Aminomethyl-phenoxy)-2,4-difluoro-3-methyl-phenoxy]-benzamidine::CHEMBL127052 Coagulation factor X Homo sapiens 1400 ChEMBL 10.1021/jm9900669 10.7270/Q2X63M5W 10508439 McDowell, LM; McCarrick, MA; Studelska, DR; Guilford, WJ; Arnaiz, D; Dallas, JL; Light, DR; Whitlow, M; Schaefer, J Washington University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081364&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44351253 103981392 CHEMBL127052 ZINC27306427 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142527 Cc1c(F)c(Oc2cccc(c2)C(N)=N)cc(Oc2cccc(c2)C(N)=N)c1F InChI=1S/C21H18F2N4O2/c1-11-18(22)16(28-14-6-2-4-12(8-14)20(24)25)10-17(19(11)23)29-15-7-3-5-13(9-15)21(26)27/h2-10H,1H3,(H3,24,25)(H3,26,27) AMIWNBPSEQZDCD-UHFFFAOYSA-N 50081365 3-(5-{3-[(Z)-amino(imino)methyl]phenoxy}-2,4-difluoro-3-methylphenoxy)benzenecarboximidamide::CHEMBL126575 Coagulation factor X Homo sapiens 12 ChEMBL 10.1021/jm9900669 10.7270/Q2X63M5W 10508439 McDowell, LM; McCarrick, MA; Studelska, DR; Guilford, WJ; Arnaiz, D; Dallas, JL; Light, DR; Whitlow, M; Schaefer, J Washington University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081365&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44351237 103981393 CHEMBL126575 ZINC27308125 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142831 NC(=N)c1ccc(O)c(CN2CC[C@H](NS(=O)(=O)c3cc4ccncc4s3)C2=O)c1 InChI=1S/C19H19N5O4S2/c20-18(21)12-1-2-15(25)13(7-12)10-24-6-4-14(19(24)26)23-30(27,28)17-8-11-3-5-22-9-16(11)29-17/h1-3,5,7-9,14,23,25H,4,6,10H2,(H3,20,21)/t14-/m0/s1 WCGRPZYMHYKYHQ-AWEZNQCLSA-N 50081499 4-Hydroxy-3-[(S)-2-oxo-3-(thieno[2,3-c]pyridine-2-sulfonylamino)-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL92530 Coagulation factor X Homo sapiens 2 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081499&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9911387 103981507 CHEMBL92530 ZINC03941833 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142835 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc4ccccc4c3)C2=O)c1 InChI=1S/C22H22N4O3S/c23-21(24)18-7-3-4-15(12-18)14-26-11-10-20(22(26)27)25-30(28,29)19-9-8-16-5-1-2-6-17(16)13-19/h1-9,12-13,20,25H,10-11,14H2,(H3,23,24)/t20-/m0/s1 NTFWSCPFRKNWEI-FQEVSTJZSA-N 50080477 3-[(S)-3-(Naphthalene-2-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine::3-[3-((S)-Naphthalene-2-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL93796::RPR-118071 Coagulation factor X Homo sapiens 230 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080477&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10574241 103980634 CHEMBL93796 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142837 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc4nc(N)ccc4c3)C2=O)c1 InChI=1S/C21H22N6O3S/c22-19-7-4-14-11-16(5-6-17(14)25-19)31(29,30)26-18-8-9-27(21(18)28)12-13-2-1-3-15(10-13)20(23)24/h1-7,10-11,18,26H,8-9,12H2,(H2,22,25)(H3,23,24)/t18-/m0/s1 FTEBBGMQNQCYMO-SFHVURJKSA-N 50081500 3-[(S)-3-(2-Amino-quinoline-6-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL92614 Coagulation factor X Homo sapiens 160 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081500&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44325967 103981508 CHEMBL92614 ZINC26666246 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142840 NC(=N)c1ccc(O)c(CN2CC[C@H](NS(=O)(=O)c3cc4ccnc(Cl)c4s3)C2=O)c1 InChI=1S/C19H18ClN5O4S2/c20-17-16-10(3-5-23-17)8-15(30-16)31(28,29)24-13-4-6-25(19(13)27)9-12-7-11(18(21)22)1-2-14(12)26/h1-3,5,7-8,13,24,26H,4,6,9H2,(H3,21,22)/t13-/m0/s1 QWKBVYMYRJYVKE-ZDUSSCGKSA-N 50081506 3-[(S)-3-(7-Chloro-thieno[2,3-c]pyridine-2-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-4-hydroxy-benzamidine::CHEMBL93151 Coagulation factor X Homo sapiens 5 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081506&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44325842 103981514 CHEMBL93151 ZINC26663294 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142842 NC(=N)c1ccc(O)c(CN2CC[C@H](NS(=O)(=O)c3cc4ncccc4s3)C2=O)c1 InChI=1S/C19H19N5O4S2/c20-18(21)11-3-4-15(25)12(8-11)10-24-7-5-13(19(24)26)23-30(27,28)17-9-14-16(29-17)2-1-6-22-14/h1-4,6,8-9,13,23,25H,5,7,10H2,(H3,20,21)/t13-/m0/s1 PQJGWYQPOHCEDO-ZDUSSCGKSA-N 14059 4-hydroxy-3-[[(3S)-2-oxo-3-(9-thia-5-azabicyclo[4.3.0]nona-2,4,7,10-tetraen-8-ylsulfonylamino)pyrrolidin-1-yl]methyl]benzenecarboximidamide::4-hydroxy-3-{[(3S)-2-oxo-3-{thieno[3,2-b]pyridine-2-sulfonamido}pyrrolidin-1-yl]methyl}benzene-1-carboximidamide::CHEMBL330572::RPR131247 Coagulation factor X Homo sapiens 0.700000 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14059&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search PR1 1F0T 5326514 46514424 CHEMBL330572 DB02744 ZINC03873901 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142843 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3cc4cccnc4s3)C2=O)c1 InChI=1S/C19H19N5O3S2/c20-17(21)13-4-1-3-12(9-13)11-24-8-6-15(19(24)25)23-29(26,27)16-10-14-5-2-7-22-18(14)28-16/h1-5,7,9-10,15,23H,6,8,11H2,(H3,20,21)/t15-/m0/s1 SKJBLMYZIUFJJM-HNNXBMFYSA-N 50081507 3-[(S)-2-Oxo-3-(thieno[2,3-b]pyridine-2-sulfonylamino)-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL328721 Coagulation factor X Homo sapiens 88 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081507&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22883583 103981515 CHEMBL328721 ZINC26652737 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142847 COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2cc(ccc2O)C(N)=N)C1=O InChI=1S/C23H24N4O5S/c1-32-18-5-2-14-3-6-19(12-16(14)11-18)33(30,31)26-20-8-9-27(23(20)29)13-17-10-15(22(24)25)4-7-21(17)28/h2-7,10-12,20,26,28H,8-9,13H2,1H3,(H3,24,25)/t20-/m0/s1 WYPLWOJSDQFHPG-FQEVSTJZSA-N 13286 4-Hydroxy-3-[3-(S)-(7-methoxynaphthalen-2-ylsulfonylamino)-2-oxopyrrolidin-1-ylmethyl]benzamidine::4-hydroxy-3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::CHEMBL93854::Sulfonamidopyrrolidinone 20a Coagulation factor X Homo sapiens 3 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13286&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10790446 46513694 CHEMBL93854 ZINC03985467 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142853 CCOc1ccc2cc(ccc2n1)S(=O)(=O)N[C@H]1CCN(Cc2cccc(c2)C(N)=N)C1=O InChI=1S/C23H25N5O4S/c1-2-32-21-9-6-16-13-18(7-8-19(16)26-21)33(30,31)27-20-10-11-28(23(20)29)14-15-4-3-5-17(12-15)22(24)25/h3-9,12-13,20,27H,2,10-11,14H2,1H3,(H3,24,25)/t20-/m0/s1 SFQMAWFBVWSKSI-FQEVSTJZSA-N 50081508 3-[(S)-3-(2-Ethoxy-quinoline-6-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL327560 Coagulation factor X Homo sapiens >1200 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081508&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44325982 103981516 CHEMBL327560 ZINC26659336 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142858 Cc1c(sc2ccc(Cl)cc12)S(=O)(=O)N[C@H]1CCN(Cc2cccc(c2)C(N)=N)C1=O InChI=1S/C21H21ClN4O3S2/c1-12-16-10-15(22)5-6-18(16)30-21(12)31(28,29)25-17-7-8-26(20(17)27)11-13-3-2-4-14(9-13)19(23)24/h2-6,9-10,17,25H,7-8,11H2,1H3,(H3,23,24)/t17-/m0/s1 LQWIPPFSKXCADI-KRWDZBQOSA-N 50081513 3-[(S)-3-(5-Chloro-3-methyl-benzo[b]thiophene-2-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL418958 Coagulation factor X Homo sapiens 36 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081513&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44325794 103981521 CHEMBL418958 ZINC26651532 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142862 COc1ccc2sc(cc2n1)S(=O)(=O)N[C@H]1CCN(Cc2cc(ccc2N)C(N)=N)C1=O InChI=1S/C20H22N6O4S2/c1-30-17-5-4-16-15(24-17)9-18(31-16)32(28,29)25-14-6-7-26(20(14)27)10-12-8-11(19(22)23)2-3-13(12)21/h2-5,8-9,14,25H,6-7,10,21H2,1H3,(H3,22,23)/t14-/m0/s1 ZENQPOAIMJIBQI-AWEZNQCLSA-N 50081515 4-Amino-3-[(S)-3-(5-methoxy-thieno[3,2-b]pyridine-2-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL96218 Coagulation factor X Homo sapiens 5 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081515&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 21967345 103981523 CHEMBL96218 ZINC26664310 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142863 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc4ccnc(N)c4c3)C2=O)c1 InChI=1S/C21H22N6O3S/c22-19(23)15-3-1-2-13(10-15)12-27-9-7-18(21(27)28)26-31(29,30)16-5-4-14-6-8-25-20(24)17(14)11-16/h1-6,8,10-11,18,26H,7,9,12H2,(H3,22,23)(H2,24,25)/t18-/m0/s1 QFBVQLZAJMRFGO-SFHVURJKSA-N 50081511 3-[(S)-3-(1-Amino-isoquinoline-7-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL93740 Coagulation factor X Homo sapiens 490.0 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081511&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44325526 103981519 CHEMBL93740 ZINC26656936 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142868 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc4nc(Cl)ccc4c3)C2=O)c1 InChI=1S/C21H20ClN5O3S/c22-19-7-4-14-11-16(5-6-17(14)25-19)31(29,30)26-18-8-9-27(21(18)28)12-13-2-1-3-15(10-13)20(23)24/h1-7,10-11,18,26H,8-9,12H2,(H3,23,24)/t18-/m0/s1 RSXHXPQRBXWJBY-SFHVURJKSA-N 50081518 3-[(S)-3-(2-Chloro-quinoline-6-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL431461 Coagulation factor X Homo sapiens 110 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081518&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44325983 103981526 CHEMBL431461 ZINC26663497 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142871 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc4ccc(N)nc4c3)C2=O)c1 InChI=1S/C21H22N6O3S/c22-19-7-5-14-4-6-16(11-18(14)25-19)31(29,30)26-17-8-9-27(21(17)28)12-13-2-1-3-15(10-13)20(23)24/h1-7,10-11,17,26H,8-9,12H2,(H2,22,25)(H3,23,24)/t17-/m0/s1 CZZBZHWZQVAYPZ-KRWDZBQOSA-N 50081519 3-[(S)-3-(2-Amino-quinoline-7-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL92893 Coagulation factor X Homo sapiens 240 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081519&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44325865 103981527 CHEMBL92893 ZINC26660057 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142872 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3cc4ncccc4s3)C2=O)c1 InChI=1S/C19H19N5O3S2/c20-18(21)13-4-1-3-12(9-13)11-24-8-6-14(19(24)25)23-29(26,27)17-10-15-16(28-17)5-2-7-22-15/h1-5,7,9-10,14,23H,6,8,11H2,(H3,20,21)/t14-/m0/s1 OQBGESKCQRRAQW-AWEZNQCLSA-N 50081011 3-[(S)-2-Oxo-3-(thieno[3,2-b]pyridine-2-sulfonylamino)-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL85757 Coagulation factor X Homo sapiens 26 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081011&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22883585 103981110 CHEMBL85757 ZINC26571705 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142874 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc4cccnc4c3)C2=O)c1 InChI=1S/C21H21N5O3S/c22-20(23)16-4-1-3-14(11-16)13-26-10-8-18(21(26)27)25-30(28,29)17-7-6-15-5-2-9-24-19(15)12-17/h1-7,9,11-12,18,25H,8,10,13H2,(H3,22,23)/t18-/m0/s1 YFLTUWNFFLMGOV-SFHVURJKSA-N 50081516 3-[(S)-2-Oxo-3-(quinoline-7-sulfonylamino)-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL93741 Coagulation factor X Homo sapiens 420 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081516&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44325527 103981524 CHEMBL93741 ZINC26656941 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142875 COc1ccc2ccc(cc2c1)S(=O)(=O)N[C@H]1CCN(Cc2cccc(c2)C(N)=N)C1=O InChI=1S/C23H24N4O4S/c1-31-19-7-5-16-6-8-20(13-18(16)12-19)32(29,30)26-21-9-10-27(23(21)28)14-15-3-2-4-17(11-15)22(24)25/h2-8,11-13,21,26H,9-10,14H2,1H3,(H3,24,25)/t21-/m0/s1 LDJWHJQMWPYZLV-NRFANRHFSA-N 13280 3-{[(3S)-3-[(7-methoxynaphthalene-2-)sulfonamido]-2-oxopyrrolidin-1-yl]methyl}benzene-1-carboximidamide::CHEMBL327600::Sulfonamidopyrrolidinone 3a Coagulation factor X Homo sapiens 47 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13280&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 9808035 46513688 CHEMBL327600 ZINC03936607 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142877 NC(=N)c1ccc(O)c(CN2CC[C@H](NS(=O)(=O)c3cc4nc(Cl)ccc4s3)C2=O)c1 InChI=1S/C19H18ClN5O4S2/c20-16-4-3-15-13(23-16)8-17(30-15)31(28,29)24-12-5-6-25(19(12)27)9-11-7-10(18(21)22)1-2-14(11)26/h1-4,7-8,12,24,26H,5-6,9H2,(H3,21,22)/t12-/m0/s1 OMACGBWDDJLXNR-LBPRGKRZSA-N 50081505 3-[(S)-3-(5-Chloro-thieno[3,2-b]pyridine-2-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-4-hydroxy-benzamidine::CHEMBL431267 Coagulation factor X Homo sapiens 1.5 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081505&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44325820 103981513 CHEMBL431267 ZINC26658440 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142878 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc4ccc(Cl)nc4c3)C2=O)c1 InChI=1S/C21H20ClN5O3S/c22-19-7-5-14-4-6-16(11-18(14)25-19)31(29,30)26-17-8-9-27(21(17)28)12-13-2-1-3-15(10-13)20(23)24/h1-7,10-11,17,26H,8-9,12H2,(H3,23,24)/t17-/m0/s1 WTHGGQKWPJEIAJ-KRWDZBQOSA-N 50081521 3-[(S)-3-(2-Chloro-quinoline-7-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL93190 Coagulation factor X Homo sapiens 720 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081521&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44325953 103981529 CHEMBL93190 ZINC26663371 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142880 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc4ccc(N)cc4c3)C2=O)c1 InChI=1S/C22H23N5O3S/c23-18-6-4-15-5-7-19(12-17(15)11-18)31(29,30)26-20-8-9-27(22(20)28)13-14-2-1-3-16(10-14)21(24)25/h1-7,10-12,20,26H,8-9,13,23H2,(H3,24,25)/t20-/m0/s1 FVWQYYWQCOZOPD-FQEVSTJZSA-N 50080499 3-[(S)-3-(7-Amino-naphthalene-2-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL93681 Coagulation factor X Homo sapiens 120 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080499&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 10765420 103980656 CHEMBL93681 ZINC13800251 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142886 NC(=N)c1ccc(O)c(CN2CC[C@H](NS(=O)(=O)c3cc4cnccc4s3)C2=O)c1 InChI=1S/C19H19N5O4S2/c20-18(21)11-1-2-15(25)13(7-11)10-24-6-4-14(19(24)26)23-30(27,28)17-8-12-9-22-5-3-16(12)29-17/h1-3,5,7-9,14,23,25H,4,6,10H2,(H3,20,21)/t14-/m0/s1 AWWJKLUXUPMJND-AWEZNQCLSA-N 50081517 4-Hydroxy-3-[(S)-2-oxo-3-(thieno[3,2-c]pyridine-2-sulfonylamino)-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL330011 Coagulation factor X Homo sapiens 3 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081517&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44325764 103981525 CHEMBL330011 ZINC26652306 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142897 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3ccc4ccncc4c3)C2=O)c1 InChI=1S/C21H21N5O3S/c22-20(23)16-3-1-2-14(10-16)13-26-9-7-19(21(26)27)25-30(28,29)18-5-4-15-6-8-24-12-17(15)11-18/h1-6,8,10-12,19,25H,7,9,13H2,(H3,22,23)/t19-/m0/s1 XCWVIZKXNXEVRL-IBGZPJMESA-N 50081504 3-[(S)-3-(Isoquinoline-7-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL327636 Coagulation factor X Homo sapiens 510 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081504&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44325939 103981512 CHEMBL327636 ZINC26658648 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142898 COc1ccc2ccc(cc2n1)S(=O)(=O)N[C@H]1CCN(Cc2cccc(c2)C(N)=N)C1=O InChI=1S/C22H23N5O4S/c1-31-20-8-6-15-5-7-17(12-19(15)25-20)32(29,30)26-18-9-10-27(22(18)28)13-14-3-2-4-16(11-14)21(23)24/h2-8,11-12,18,26H,9-10,13H2,1H3,(H3,23,24)/t18-/m0/s1 MWBZRPNPPVXYNJ-SFHVURJKSA-N 50081514 3-[(S)-3-(2-Methoxy-quinoline-7-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL93431 Coagulation factor X Homo sapiens 480 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081514&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 44325938 103981522 CHEMBL93431 ZINC26658642 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142903 NC(=N)c1cccc(CN2CC[C@H](NS(=O)(=O)c3cc4c(Cl)nccc4s3)C2=O)c1 InChI=1S/C19H18ClN5O3S2/c20-17-13-9-16(29-15(13)4-6-23-17)30(27,28)24-14-5-7-25(19(14)26)10-11-2-1-3-12(8-11)18(21)22/h1-4,6,8-9,14,24H,5,7,10H2,(H3,21,22)/t14-/m0/s1 FUPVQKDKIXJWIU-AWEZNQCLSA-N 50081509 3-[(S)-3-(4-Chloro-thieno[3,2-c]pyridine-2-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL314754 Coagulation factor X Homo sapiens 39 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081509&enzyme=Coagulation+factor+X&column=ki&startPg=0&Increment=50&submit=Search 22883547 103981517 CHEMBL314754 ZINC26657037 1 MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK 1C5M,1EZQ,1F0R,1F0S,1FAX,1FJS,1G2L,1G2M,1HCG,1IOE,1IQE,1IQF,1IQG,1IQH,1IQI,1IQJ,1IQK,1IQL,1IQM,1IQN,1KSN,1LPG,1LPK,1LPZ,1LQD,1MQ5,1MQ6,1NFU,1NFW,1NFX,1NFY,1P0S,1V3X,1WU1,1XKA,1XKB,1Z6E,2BMG,2BOH,2BOK,2BQ6,2BQ7,2BQW,2CJI,2D1J,2EI6,2EI7,2EI8,2FZZ,2G00,2GD4,2H9E,2J2U,2J34,2J38,2J4I,2J94,2J95,2JKH,2P16,2P3F,2P3T,2P3U,2P93,2P94,2P95,2PHB,2PR3,2Q1J,2RA0,2UWL,2UWO,2UWP,2VH0,2VH6,2VVC,2VVU,2VVV,2VWL,2VWM,2VWN,2VWO,2W26,2W3I,2W3K,2WYG,2WYJ,2XBV,2XBW,2XBX,2XBY,2XC0,2XC4,2XC5,2Y5F,2Y5G,2Y5H,2Y7X,2Y7Z,2Y80,2Y81,2Y82,3CEN,3CS7,3ENS,3FFG,3HPT,3IIT,3K9X,3KL6,3KQB,3KQC,3KQD,3KQE,3LIW,3M36,3M37,3Q3K,3SW2,3TK5,3TK6,4A7I,4BTI,4BTT,4BTU,4Y6D,4Y71,4Y76,4Y79,4Y7A,4Y7B,4ZH8,4ZHA,5K0H,5VOE,5VOF,7AHU,7TPP,7TPQ Coagulation factor X FA10_HUMAN P00742 Q14340 50142906 NC(=N)c1ccc(N)c(CN2CC[C@H](NS(=O)(=O)c3cc4nc(Cl)ccc4s3)C2=O)c1 InChI=1S/C19H19ClN6O3S2/c20-16-4-3-15-14(24-16)8-17(30-15)31(28,29)25-13-5-6-26(19(13)27)9-11-7-10(18(22)23)1-2-12(11)21/h1-4,7-8,13,25H,5-6,9,21H2,(H3,22,23)/t13-/m0/s1 VNBAVMHWKPMKEO-ZDUSSCGKSA-N 50081510 4-Amino-3-[(S)-3-(5-chloro-thieno[3,2-b]pyridine-2-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine::CHEMBL431281 Coagulation factor X Homo sapiens 3 ChEMBL 10.1016/s0960-894x(99)00466-7 10.7270/Q2W66K02 10509929 Becker, MR; Ewing, WR; Davis, RS; Pauls, HW; Ly, C; Li, A; Mason, HJ; Choi-Sledeski, YM; Spada, AP; Chu, V; Brown, KD; Colussi, DJ; Leadley, RJ; Bentley, R; Bostwick, J; Kasiewski, C; Morgan, S Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1341&target=Coagulation+factor+X&colum