BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 767050 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(Cl)cc(Cl)c1 InChI=1S/C17H18Cl2N6/c1-17(20)2-4-25(5-3-17)13-9-21-15-14(23-24-16(15)22-13)10-6-11(18)8-12(19)7-10/h6-9H,2-5,20H2,1H3,(H,22,23,24) ZLSAGPLZHAPKDO-UHFFFAOYSA-N 384126 1-(3-(3,5-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 12::US10851110, Example 12::US11466017, Example 12 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 404 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384126&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166892 404853412 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767052 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C18H20Cl2N6/c1-18(10-21)4-6-26(7-5-18)14-9-22-16-15(24-25-17(16)23-14)11-2-3-12(19)13(20)8-11/h2-3,8-9H,4-7,10,21H2,1H3,(H,23,24,25) LJXXZVLIMZSWLE-UHFFFAOYSA-N 384127 (1-(3-(3,4-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 13::US10851110, Example 13::US11466017, Example 13 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 158 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384127&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167147 404853413 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767054 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(F)c(Cl)c1 InChI=1S/C18H20ClFN6/c1-18(10-21)4-6-26(7-5-18)14-9-22-16-15(24-25-17(16)23-14)11-2-3-13(20)12(19)8-11/h2-3,8-9H,4-7,10,21H2,1H3,(H,23,24,25) HXKDFUSJAFLWKF-UHFFFAOYSA-N 384128 (1-(3-(3-Chloro-4- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 14::US10851110, Example 14::US11466017, Example 14 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 521 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384128&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166905 404853414 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767056 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)cc1 InChI=1S/C17H19ClN6/c1-17(19)6-8-24(9-7-17)13-10-20-15-14(22-23-16(15)21-13)11-2-4-12(18)5-3-11/h2-5,10H,6-9,19H2,1H3,(H,21,22,23) MGGGLWKKMYVXPD-UHFFFAOYSA-N 384129 1-(3-(4-Chlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-amine::US10280171, Example 15::US10851110, Example 15::US11466017, Example 15::US11529347, Compound 17 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 140 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384129&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166901 404853415 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767058 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)cc1 InChI=1S/C18H21ClN6/c1-18(11-20)6-8-25(9-7-18)14-10-21-16-15(23-24-17(16)22-14)12-2-4-13(19)5-3-12/h2-5,10H,6-9,11,20H2,1H3,(H,22,23,24) BHDQDMSKLZFAOP-UHFFFAOYSA-N 384130 (1-(3-(4-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin- methanamine::US10280171, Example 16::US10851110, Example 16::US11466017, Example 16::US11529347, Compound 29 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 169 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384130&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176105 404853416 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767060 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)cc1 384131 (R)-8-(3-(4-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 17::US10851110, Example 17 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 118 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384131&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166931 404853417 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767062 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C17H18Cl2N6/c1-17(20)4-6-25(7-5-17)13-9-21-15-14(23-24-16(15)22-13)10-2-3-11(18)12(19)8-10/h2-3,8-9H,4-7,20H2,1H3,(H,22,23,24) IEUPVYYCTFCLTF-UHFFFAOYSA-N 384132 1-(3-(3,4-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 18::US10851110, Example 18::US11466017, Example 18 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 141 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384132&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167085 404853418 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767064 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(F)c(Cl)c1 InChI=1S/C17H18ClFN6/c1-17(20)4-6-25(7-5-17)13-9-21-15-14(23-24-16(15)22-13)10-2-3-12(19)11(18)8-10/h2-3,8-9H,4-7,20H2,1H3,(H,22,23,24) HILFUTGZGNSLCF-UHFFFAOYSA-N 384133 1-(3-(3-Chloro-4- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 19::US10851110, Example 19::US11466017, Example 19 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 510 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384133&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166896 404853419 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767066 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl InChI=1S/C17H19ClN6/c1-17(19)6-8-24(9-7-17)13-10-20-15-14(22-23-16(15)21-13)11-4-2-3-5-12(11)18/h2-5,10H,6-9,19H2,1H3,(H,21,22,23) JQWPQEJDTUKOCS-UHFFFAOYSA-N 384134 1-(3-(2- Chlorophenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 20::US10851110, Example 20::US11466017, Example 20::US11529347, Compound 6 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 326 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384134&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167115 404853420 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767068 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(c1)C(F)(F)F InChI=1S/C18H19F3N6/c1-17(22)5-7-27(8-6-17)13-10-23-15-14(25-26-16(15)24-13)11-3-2-4-12(9-11)18(19,20)21/h2-4,9-10H,5-8,22H2,1H3,(H,24,25,26) UCVNJKUCRRXAMU-UHFFFAOYSA-N 384135 4-Methyl-1-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)piperidin-4-amine::US10280171, Example 21::US10851110, Example 21::US11466017, Example 21 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 956 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384135&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166903 404853421 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767070 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(c1)C(F)(F)F InChI=1S/C19H21F3N6/c1-18(11-23)5-7-28(8-6-18)14-10-24-16-15(26-27-17(16)25-14)12-3-2-4-13(9-12)19(20,21)22/h2-4,9-10H,5-8,11,23H2,1H3,(H,25,26,27) VBWUNPVCLSZAAP-UHFFFAOYSA-N 384136 (4-methyl-1-(3-(3- (trifluoromethyl)- phenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)- piperidin-4-yl)- methanamine::US10280171, Example 22::US10851110, Example 22::US11466017, Example 22 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1747 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384136&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167094 404853422 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767072 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccnc1Cl InChI=1S/C16H18ClN7/c1-16(18)4-7-24(8-5-16)11-9-20-13-12(22-23-15(13)21-11)10-3-2-6-19-14(10)17/h2-3,6,9H,4-5,7-8,18H2,1H3,(H,21,22,23) KUMMBNPRGBFMLN-UHFFFAOYSA-N 384137 1-(3-(2-chloro- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methyl-piperidin-4- amine::US10280171, Example 23::US10851110, Example 23::US11466017, Example 23 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1824 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384137&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166863 404853423 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767074 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(F)c1Cl InChI=1S/C17H18ClFN6/c1-17(20)5-7-25(8-6-17)12-9-21-15-14(23-24-16(15)22-12)10-3-2-4-11(19)13(10)18/h2-4,9H,5-8,20H2,1H3,(H,22,23,24) QKNOZCPUZKQEHX-UHFFFAOYSA-N 384138 1-(3-(2-chloro-3- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methyl-piperidin-4- amine::US10280171, Example 24::US10851110, Example 24::US11466017, Example 24 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 204 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384138&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166810 404853424 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767076 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1F InChI=1S/C18H20ClFN6/c1-18(10-21)5-7-26(8-6-18)13-9-22-16-15(24-25-17(16)23-13)11-3-2-4-12(19)14(11)20/h2-4,9H,5-8,10,21H2,1H3,(H,23,24,25) CUTMOOSDQSRDHK-UHFFFAOYSA-N 384139 (1-(3-(3-Chloro-2-fluorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)-methanamine::US10280171, Example 25::US10851110, Example 25::US11466017, Example 25::US11529347, Compound 48 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 101 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384139&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166994 404853425 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767078 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1F InChI=1S/C17H18ClFN6/c1-17(20)5-7-25(8-6-17)12-9-21-15-14(23-24-16(15)22-12)10-3-2-4-11(18)13(10)19/h2-4,9H,5-8,20H2,1H3,(H,22,23,24) QROQTLNVCIGXBV-UHFFFAOYSA-N 384140 1-(3-(3-chloro-2- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 26::US10851110, Example 26::US11466017, Example 26::US11529347, Compound 7 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 213 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384140&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166959 404853426 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767079 COc1cccc(-c2n[nH]c3nc(cnc23)N2CCC(C)(CN)CC2)c1Cl InChI=1S/C19H23ClN6O/c1-19(11-21)6-8-26(9-7-19)14-10-22-17-16(24-25-18(17)23-14)12-4-3-5-13(27-2)15(12)20/h3-5,10H,6-9,11,21H2,1-2H3,(H,23,24,25) NQCYZSVEYSASFG-UHFFFAOYSA-N 384141 (1-(3-(2-chloro-3- methoxy phenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 27::US10851110, Example 27::US11466017, Example 27::US11529347, Compound 39 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 80.0 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384141&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166928 404853427 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767081 Cc1c(Cl)cccc1-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 InChI=1S/C19H23ClN6/c1-12-13(4-3-5-14(12)20)16-17-18(25-24-16)23-15(10-22-17)26-8-6-19(2,11-21)7-9-26/h3-5,10H,6-9,11,21H2,1-2H3,(H,23,24,25) DEVINZPHNDARNY-UHFFFAOYSA-N 384142 (1-(3-(3-chloro-2- methylphenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 28::US10851110, Example 28::US11466017, Example 28 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 142 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384142&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166891 404853428 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767083 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl InChI=1S/C18H21ClN6/c1-18(11-20)6-8-25(9-7-18)14-10-21-16-15(23-24-17(16)22-14)12-4-2-3-5-13(12)19/h2-5,10H,6-9,11,20H2,1H3,(H,22,23,24) JCYHCBVXAFUBRD-UHFFFAOYSA-N 384143 (1-(3-(2-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin- methanamine::US10280171, Example 29::US10851110, Example 29::US11466017, Example 29::US11529347, Compound 43 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 178 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384143&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176109 404853429 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767085 Cc1ncccc1-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 InChI=1S/C18H23N7/c1-12-13(4-3-7-20-12)15-16-17(24-23-15)22-14(10-21-16)25-8-5-18(2,11-19)6-9-25/h3-4,7,10H,5-6,8-9,11,19H2,1-2H3,(H,22,23,24) UJEPRQRVJYIQTG-UHFFFAOYSA-N 384144 (4-methyl-1-(3-(2- methylpyridin-3-yl)- 1H-pyrazolo[3,4- b]pyrazin-6-yl)- piperidin-4-yl) methanamine::US10280171, Example 30::US10851110, Example 30::US11466017, Example 30 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 2509 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384144&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166785 404853430 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767087 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccncc1Cl InChI=1S/C17H20ClN7/c1-17(10-19)3-6-25(7-4-17)13-9-21-15-14(23-24-16(15)22-13)11-2-5-20-8-12(11)18/h2,5,8-9H,3-4,6-7,10,19H2,1H3,(H,22,23,24) HZYUNIMXNROZHD-UHFFFAOYSA-N 384145 (1-(3-(3-chloro- pyridin-4-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 31::US10851110, Example 31::US11466017, Example 31 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 929 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384145&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167009 404853431 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767090 COc1cc(ccc1Cl)-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 InChI=1S/C19H23ClN6O/c1-19(11-21)5-7-26(8-6-19)15-10-22-17-16(24-25-18(17)23-15)12-3-4-13(20)14(9-12)27-2/h3-4,9-10H,5-8,11,21H2,1-2H3,(H,23,24,25) XEMDEEZOTNHZCZ-UHFFFAOYSA-N 384147 (1-(3-(4-Chloro-3-methoxyphenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)methanamine::US10280171, Example 33::US10851110, Example 33::US11466017, Example 33 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 72.0 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384147&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166819 404853433 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767092 COc1cc(ccc1Cl)-c1n[nH]c2nc(cnc12)N1CCC2(CCC[C@H]2N)CC1 384148 (R)-8-(3-(4-chloro-3- methoxyphenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 34::US10851110, Example 34::US11466017, Example 34 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 102 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384148&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166932 404853434 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767093 COc1cc(Cl)cc(c1)-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 InChI=1S/C19H23ClN6O/c1-19(11-21)3-5-26(6-4-19)15-10-22-17-16(24-25-18(17)23-15)12-7-13(20)9-14(8-12)27-2/h7-10H,3-6,11,21H2,1-2H3,(H,23,24,25) ZXABOENZJMEVQC-UHFFFAOYSA-N 384149 (1-(3-(3-chloro-5- methoxyphenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 35::US10851110, Example 35::US11466017, Example 35 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 304 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384149&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167103 404853435 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767095 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccnc1Cl InChI=1S/C17H20ClN7/c1-17(10-19)4-7-25(8-5-17)12-9-21-14-13(23-24-16(14)22-12)11-3-2-6-20-15(11)18/h2-3,6,9H,4-5,7-8,10,19H2,1H3,(H,22,23,24) ACZCNRCVPUGLCW-UHFFFAOYSA-N 384150 (1-(3-(2-chloro- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 36::US10851110, Example 36::US11466017, Example 36 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 967 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384150&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166991 404853436 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767097 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(F)c1Cl InChI=1S/C17H18ClFN6O/c18-13-10(2-1-3-11(13)19)14-15-16(24-23-14)22-12(8-21-15)25-6-4-17(26,9-20)5-7-25/h1-3,8,26H,4-7,9,20H2,(H,22,23,24) YFIASUMJKJCVBV-UHFFFAOYSA-N 384151 4-(Aminomethyl)-1-(3-(2-chloro-3-fluorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-piperidin-4-ol::US10280171, Example 37::US10851110, Example 37::US11466017, Example 37 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 623 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384151&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166812 404853437 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767099 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 384152 (S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2-oxa-8-azaspiro[4.5]-decan-4-amine::US10280171, Example 38::US10851110, Example 38::US11466017, Example 38 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 75.0 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384152&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166974 404853438 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767101 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl 384153 (S)-8-(3-(2-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-2-oxa- 8-azaspiro[4.5]- decan-4-amine::US10280171, Example 39::US10851110, Example 39::US11466017, Example 39 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 158 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384153&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166852 404853439 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767103 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1c(F)cccc1Cl 384154 (4S)-8-(3-(2-Chloro- 6-fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-2-oxa- 8-azaspiro[4.5]- decan-4-amine::US10280171, Example 40::US10851110, Example 40::US11466017, Example 40 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 203 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384154&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167117 404853440 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767105 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccnc1Cl 384155 (S)-8-(3-(2-chloro- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-2-oxa- 8-azaspiro[4.5]- decan-4-amine trifluoroacetate::US10280171, Example 41::US10851110, Example 41::US11466017, Example 41 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 966 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384155&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166850 404853441 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767108 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1 384157 (R)-8-(3-(3-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]-decan-1- amine::US10280171, Example 44::US10851110, Example 44::US11466017, Example 44 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 429 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384157&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166809 404853443 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767110 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(Cl)cc(Cl)c1 384158 (R)-8-(3-(3,5-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 45::US10851110, Example 45::US11466017, Example 45 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 355 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384158&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166912 404853444 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767112 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)c(Cl)c1 384159 (R)-8-(3-(3,4-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 46::US10851110, Example 46::US11466017, Example 46 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 193 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384159&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167057 404853445 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767114 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(F)c(Cl)c1 384160 (R)-8-(3-(3-chloro-4- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 47::US10851110, Example 47::US11466017, Example 47 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 493 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384160&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166800 404853446 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767116 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(c1)C(F)(F)F 384161 (R)-8-(3-(3- (trifluoromethyl)- phenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 48::US10851110, Example 48::US11466017, Example 48 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1756 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384161&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167130 404853447 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767118 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1F 384162 (R)-8-(3-(3-chloro-2- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 49::US10851110, Example 49::US11466017, Example 49 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 143 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384162&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166940 404853448 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767120 COc1cccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCC[C@H]3N)CC2)c1Cl 384163 (R)-8-(3-(2-chloro-3- methoxyphenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 50::US10851110, Example 50::US11466017, Example 50 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 39.0 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384163&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167017 404853449 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767122 Cc1c(Cl)cccc1-c1n[nH]c2nc(cnc12)N1CCC2(CCC[C@H]2N)CC1 384164 (R)-8-(3-(3-chloro-2- methylphenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 51::US10851110, Example 51::US11466017, Example 51 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 153 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384164&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166886 404853450 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767123 COc1cc(Cl)cc(c1)-c1n[nH]c2nc(cnc12)N1CCC2(CCC[C@H]2N)CC1 384165 (R)-8-(3-(3-chloro-5- methoxyphenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 52::US10851110, Example 52::US11466017, Example 52 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 313 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384165&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167063 404853451 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767124 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccnc1Cl 384166 (R)-8-(3-(2-chloro- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8- aza- spiro[4.5]decan-1- amine::US10280171, Example 53::US10851110, Example 56::US11466017, Example 53 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 641 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384166&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166913 404853452 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767126 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl 384167 (R)-8-(3-(2- chlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 54::US10851110, Example 54::US11466017, Example 54::US11529347, Compound 16 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 119 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384167&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167004 404853453 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767128 Cc1ncccc1-c1n[nH]c2nc(cnc12)N1CCC2(CCC[C@H]2N)CC1 384168 (R)-8-(3-(2-methyl- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8- azaspiro[4.5]decan- I -amine::US10280171, Example 55::US10851110, Example 55::US11466017, Example 55 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1143 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384168&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176111 404853454 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767130 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccncc1Cl 384169 (R)-8-(3-(3-chloro- pyridin-4-y l)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 56::US11466017, Example 56 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 552 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384169&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166830 404853455 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767132 NC1(CO)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C17H18Cl2N6O/c18-11-3-1-2-10(13(11)19)14-15-16(24-23-14)22-12(8-21-15)25-6-4-17(20,9-26)5-7-25/h1-3,8,26H,4-7,9,20H2,(H,22,23,24) YCRNZPYPOFXDCB-UHFFFAOYSA-N 384170 (4-Amino-1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)piperidin-4-yl)-methanol::US10280171, Example 57::US10851110, Example 57::US11466017, Example 57 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 104 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384170&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166807 404853456 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767134 NC1(CF)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C17H17Cl2FN6/c18-11-3-1-2-10(13(11)19)14-15-16(25-24-14)23-12(8-22-15)26-6-4-17(21,9-20)5-7-26/h1-3,8H,4-7,9,21H2,(H,23,24,25) KCRBJSWWABFQLC-UHFFFAOYSA-N 384171 1-(3-(2,3-dichlo- rophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- (fluoromethyl)- piperidin-4-amine::US10280171, Example 58::US10851110, Example 58::US11466017, Example 58 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 338 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384171&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176113 404853457 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767137 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl InChI=1S/C17H19ClN6O/c18-12-4-2-1-3-11(12)14-15-16(23-22-14)21-13(9-20-15)24-7-5-17(25,10-19)6-8-24/h1-4,9,25H,5-8,10,19H2,(H,21,22,23) YMDXJDQSJVLAPR-UHFFFAOYSA-N 384173 4-(aminomethyl)-1- (3-(2-chlorophenyl)- 1H-pyrazolo[3,4-b]- pyrazin-6-yl)- piperidin-4-ol::US10280171, Example 60::US10851110, Example 60::US11466017, Example 60::US11529347, Compound 52 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 918 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384173&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166856 404853459 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767139 NC1(CO)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl InChI=1S/C17H19ClN6O/c18-12-4-2-1-3-11(12)14-15-16(23-22-14)21-13(9-20-15)24-7-5-17(19,10-25)6-8-24/h1-4,9,25H,5-8,10,19H2,(H,21,22,23) DCZHDAUEYSJCLK-UHFFFAOYSA-N 384174 (4-amino-1-(3-(2- chlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)- piperidin-4-yl)- methanol::US10280171, Example 61::US10851110, Example 61::US11529347, Compound 56 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 401 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384174&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166804 404853460 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767143 NC1[C@H](F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 384177 8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2-fluoro-8-azaspiro[4.5]decan-1-amine::US10280171, Example 64A Tyrosine-protein phosphatase non-receptor type 11 [E76K] 98.0 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384177&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 145996016 404853463 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767145 NC1[C@@H](F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 384178 US10280171, Example 64B Tyrosine-protein phosphatase non-receptor type 11 [E76K] 221 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384178&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 145996017 404853464 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767147 NC1C(F)(F)CC[C@]11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 384179 8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2,2-difluoro-8-azaspiro[4.5]decan-1-amine::US10280171, Example 65A::US10280171, Example 65B Tyrosine-protein phosphatase non-receptor type 11 [E76K] 235 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384179&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167135 404853465 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767149 NC1C(F)(F)CC[C@]11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 384179 8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2,2-difluoro-8-azaspiro[4.5]decan-1-amine::US10280171, Example 65A::US10280171, Example 65B Tyrosine-protein phosphatase non-receptor type 11 [E76K] 471 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384179&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167135 404853465 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767151 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cn[nH]c1C(F)(F)F InChI=1S/C15H15F3N8/c1-14(19)2-4-26(5-3-14)9-7-20-11-10(23-25-13(11)22-9)8-6-21-24-12(8)15(16,17)18/h6-7H,2-5,19H2,1H3/b10-8- KZPBYVFZYXDAKG-NTMALXAHSA-N 384181 4-Methyl-1-(3-(5-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-piperidin-4-amine::US10280171, Example 101::US10851110, Example 101::US11466017, Example 101 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1894 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384181&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166754 404853466 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767153 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cn[nH]c1C(F)(F)F InChI=1S/C18H19F3N8/c19-18(20,21)15-10(8-24-27-15)13-14-16(28-26-13)25-12(9-23-14)29-6-4-17(5-7-29)3-1-2-11(17)22/h8-9,11H,1-7,22H2/b13-10-/t11-/m1/s1 JQQQFWFXYNBFCC-COVOJHCQSA-N 384182 (R)-8-(3-(5-(Trifluoromethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-1-amine::US10280171, Example 102::US10851110, Example 102::US11466017, Example 102 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 2154 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384182&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166930 404853467 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767155 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cn[nH]c1C(F)(F)F InChI=1S/C16H17F3N8/c1-15(8-20)2-4-27(5-3-15)10-7-21-12-11(24-26-14(12)23-10)9-6-22-25-13(9)16(17,18)19/h6-7H,2-5,8,20H2,1H3/b11-9- ZFBUAYQZKUQVSN-LUAWRHEFSA-N 384183 (R)-8-(3-(5-(Trifluoromethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-1-amine::US10280171, Example 103::US10851110, Example 103::US11466017, Example 103 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 2603 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384183&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166827 404853468 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767157 CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC(C)(CN)CC2)c1Cl InChI=1S/C18H23ClN8/c1-18(10-20)4-7-27(8-5-18)12-9-23-15-14(25-26-17(15)24-12)11-3-6-22-16(21-2)13(11)19/h3,6,9H,4-5,7-8,10,20H2,1-2H3,(H,21,22)(H,24,25,26) WCBNKFWTMBJQOT-UHFFFAOYSA-N 384184 4-(6-(4-(Aminomethyl)-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloro-N-methylpyridin-2-amine::US10280171, Example 104::US10851110, Example 104::US11466017, Example 104 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 99.0 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384184&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167058 404853469 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767159 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(N)c1Cl InChI=1S/C17H20ClN7/c1-17(20)5-7-25(8-6-17)12-9-21-15-14(23-24-16(15)22-12)10-3-2-4-11(19)13(10)18/h2-4,9H,5-8,19-20H2,1H3,(H,22,23,24) QUZYGWHMIMOARM-UHFFFAOYSA-N 384185 1-(3-(3-amino-2-chlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-amine::US10280171, Example 105::US10851110, Example 105::US11466017, Example 105 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 191 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384185&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166876 404853470 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767161 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl InChI=1S/C16H19ClN8/c1-16(19)3-6-25(7-4-16)10-8-21-13-12(23-24-15(13)22-10)9-2-5-20-14(18)11(9)17/h2,5,8H,3-4,6-7,19H2,1H3,(H2,18,20)(H,22,23,24) ZSNQCYQABMACIK-UHFFFAOYSA-N 384186 4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-3-chloropyridin-2-amine::US10280171, Example 106::US10851110, Example 106::US11466017, Example 106 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 253 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384186&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166751 404853471 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767163 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl InChI=1S/C17H21ClN8/c1-17(9-19)3-6-26(7-4-17)11-8-22-14-13(24-25-16(14)23-11)10-2-5-21-15(20)12(10)18/h2,5,8H,3-4,6-7,9,19H2,1H3,(H2,20,21)(H,23,24,25) POYNJTHRRZRCMC-UHFFFAOYSA-N 384187 4-(6-(4-(Aminomethyl)-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-amine::US10280171, Example 107::US10851110, Example 107::US11466017, Example 107 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 162 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384187&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167030 404853472 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767165 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl 384188 4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-amine::US10280171, Example 108::US10851110, Example 108::US11466017, Example 108 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 726 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384188&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166878 404853473 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767167 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl 384189 (S)-4-(6-(4-Amino-2-oxa-8-azaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-ol::US10280171, Example 109::US10851110, Example 109::US11466017, Example 109 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1095 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384189&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166793 404853474 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767169 NC1(CO)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl InChI=1S/C16H18ClN7O2/c17-11-9(1-4-19-15(11)26)12-13-14(23-22-12)21-10(7-20-13)24-5-2-16(18,8-25)3-6-24/h1,4,7,25H,2-3,5-6,8,18H2,(H,19,26)(H,21,22,23) GZGWPZGIPUFBJS-UHFFFAOYSA-N 384190 4-(6-(4-Amino-4-(hydroxymethyl)piperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-ol::US10280171, Example 110::US10851110, Example 110::US11466017, Example 110 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 3679 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384190&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166946 404853475 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767171 CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCC[C@H]3N)CC2)c1Cl 384191 (R)-8-(3-(3-Chloro-2-(methylamino)pyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-1-amine::US10280171, Example 111::US10851110, Example 111::US11466017, Example 111 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 43.0 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384191&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166783 404853476 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767173 CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC(C)(N)CC2)c1Cl InChI=1S/C17H21ClN8/c1-17(19)4-7-26(8-5-17)11-9-22-14-13(24-25-16(14)23-11)10-3-6-21-15(20-2)12(10)18/h3,6,9H,4-5,7-8,19H2,1-2H3,(H,20,21)(H,23,24,25) XLKDUTBYZJONNW-UHFFFAOYSA-N 384192 4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloro-N-methylpyridin-2-amine::US10280171, Example 112::US10851110, Example 112::US11466017, Example 112 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 128 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384192&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 37I 7R7D 132166808 404853477 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767175 COc1ccc(CNc2nccc(C(=O)c3ncc(nc3Cl)N3CCC(C)(CC3)[C@@H](C)NS(=O)C(C)(C)C)c2Cl)cc1 InChI=1S/C30H38Cl2N6O3S/c1-19(37-42(40)29(2,3)4)30(5)12-15-38(16-13-30)23-18-34-25(27(32)36-23)26(39)22-11-14-33-28(24(22)31)35-17-20-7-9-21(41-6)10-8-20/h7-11,14,18-19,37H,12-13,15-17H2,1-6H3,(H,33,35)/t19-,42?/m1/s1 BAPWXYXPJRISAE-SMQOYFIQSA-N 384193 (R)-N-(1-(1-(6-chloro-5-(3-chloro-2-(4-methoxybenzylamino)isonicotinoyl)-pyrazin-2-yl)-4-methylpiperidin-4-yl)ethyl)-2-methylpropane-2-sulfinamide::US10280171, Example 113a Tyrosine-protein phosphatase non-receptor type 11 [E76K] 180 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384193&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167078 404853478 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767177 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl InChI=1S/C16H19ClN8O/c17-11-9(1-4-20-14(11)19)12-13-15(24-23-12)22-10(7-21-13)25-5-2-16(26,8-18)3-6-25/h1,4,7,26H,2-3,5-6,8,18H2,(H2,19,20)(H,22,23,24) QJPILDDCQKPWJV-UHFFFAOYSA-N 384194 1-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-(aminomethyl)piperidin-4-ol::US10280171, Example 114::US10851110, Example 114::US11466017, Example 114 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 779 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384194&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166791 404853479 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767179 NC1CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384195 7-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-7-azaspiro[3.5]nonan-1-amine::US10280171, Example 115::US10851110, Example 136b::US11466017, Example 115 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 701 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384195&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166895 404853480 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767181 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384196 (S)-8-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2-oxa-8-azaspiro[4.5]decan-4-amine::US10280171, Example 116::US10851110, Example 116::US11466017, Example 116 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 132 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384196&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167093 404853481 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767183 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl InChI=1S/C16H18ClN7O/c1-16(18)3-6-24(7-4-16)10-8-20-13-12(22-23-14(13)21-10)9-2-5-19-15(25)11(9)17/h2,5,8H,3-4,6-7,18H2,1H3,(H,19,25)(H,21,22,23) DVTOAVZTUJPMMJ-UHFFFAOYSA-N 384197 4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-ol::US10280171, Example 117::US10851110, Example 117::US11466017, Example 117 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1941 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384197&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166752 404853482 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767185 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl InChI=1S/C17H20ClN7O/c1-17(9-19)3-6-25(7-4-17)11-8-21-14-13(23-24-15(14)22-11)10-2-5-20-16(26)12(10)18/h2,5,8H,3-4,6-7,9,19H2,1H3,(H,20,26)(H,22,23,24) NRGYUJKDKQWLQO-UHFFFAOYSA-N 384198 1-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4(aminomethyl)piperidin-4-ol::US10280171, Example 118::US10851110, Example 118::US11466017, Example 118 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1128 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384198&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166938 404853483 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767187 Nc1nccc(-c2n[nH]c3nc(cnc23)N2CCC(N)(CO)CC2)c1Cl InChI=1S/C16H19ClN8O/c17-11-9(1-4-20-14(11)18)12-13-15(24-23-12)22-10(7-21-13)25-5-2-16(19,8-26)3-6-25/h1,4,7,26H,2-3,5-6,8,19H2,(H2,18,20)(H,22,23,24) QPRIEZJKJCCITA-UHFFFAOYSA-N 384199 (4-Amino-1-(3-(2-amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-piperidin-4-yl)methanol::US10280171, Example 119::US10851110, Example 119::US11466017, Example 119 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 422 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384199&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167100 404853484 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767189 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl InChI=1S/C16H18ClN7O2/c17-11-9(1-4-19-15(11)25)12-13-14(23-22-12)21-10(7-20-13)24-5-2-16(26,8-18)3-6-24/h1,4,7,26H,2-3,5-6,8,18H2,(H,19,25)(H,21,22,23) GVSONOQWYKOEOK-UHFFFAOYSA-N 384200 4-(6-(4-(Aminomethyl)-4-hydroxypiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-ol::US10280171, Example 120::US10851110, Example 120::US11466017, Example 120 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 5372 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384200&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166893 404853485 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767191 NC1(CO)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1c(F)cccc1Cl InChI=1S/C17H18ClFN6O/c18-10-2-1-3-11(19)13(10)14-15-16(24-23-14)22-12(8-21-15)25-6-4-17(20,9-26)5-7-25/h1-3,8,26H,4-7,9,20H2,(H,22,23,24) ZECYCODHSVTEAW-UHFFFAOYSA-N 384201 (4-Amino-1-(3-(2-chloro-6-fluorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-piperidin-4-yl)methanol::US10280171, Example 121::US10851110, Example 121::US11466017, Example 121 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1083 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384201&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166873 404853486 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767193 Cc1c(N)nccc1C(=N)c1ncc(nc1N)N1CCC2(CCC[C@H]2N)CC1 InChI=1S/C20H28N8/c1-12-13(4-8-25-18(12)23)16(22)17-19(24)27-15(11-26-17)28-9-6-20(7-10-28)5-2-3-14(20)21/h4,8,11,14,22H,2-3,5-7,9-10,21H2,1H3,(H2,23,25)(H2,24,27)/t14-/m1/s1 YKPSFYUUWIGQNJ-CQSZACIVSA-N 384202 3-(2,3-Dichlorophenyl)-6-(2,8-diazaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-b]pyrazine::US10280171, Example 122 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 205 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384202&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176118 404853487 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767194 Cc1c(N)nccc1-c1n[nH]c2nc(cnc12)N1CCC(C)(N)CC1 InChI=1S/C17H22N8/c1-10-11(3-6-20-15(10)18)13-14-16(24-23-13)22-12(9-21-14)25-7-4-17(2,19)5-8-25/h3,6,9H,4-5,7-8,19H2,1-2H3,(H2,18,20)(H,22,23,24) DMNYIHIRUJAKGX-UHFFFAOYSA-N 384203 4-(6-(4-amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-methylpyridin-2-amine::US10280171, Example 123::US10851110, Example 123::US11466017, Example 123 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 670 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384203&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166867 404853488 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767195 Cc1c(N)nccc1-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 InChI=1S/C18H24N8/c1-11-12(3-6-21-16(11)20)14-15-17(25-24-14)23-13(9-22-15)26-7-4-18(2,10-19)5-8-26/h3,6,9H,4-5,7-8,10,19H2,1-2H3,(H2,20,21)(H,23,24,25) LLWQCPSJCBXVHN-UHFFFAOYSA-N 384204 4-(6-(4-(Aminomethyl)-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-methylpyridin-2-amine::US10280171, Example 124::US10851110, Example 124::US11466017, Example 124 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 377 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384204&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167121 404853489 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767196 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(N)ncc1Cl 384205 (R)-8-(3-(2-amino-5-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-1-amine::US10280171, Example 125::US10851110, Example 125::US11466017, Example 125 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 509 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384205&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166759 404853490 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767198 N[C@@H]1C[C@@H](O)CC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384206 (2S,4R)-4-Amino-8-(3-(2-amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-2-ol::US10280171, Example 126::US10851110, Example 126::US11466017, Example 126 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 75.0 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384206&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166963 404853491 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767199 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384207 (1R)-8-[3-(2-amino- 3-chloropyridin-4- yl)-1H-pyrazolo[3,4- b]pyrazin-6-yl]-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 130::US10851110, Example 130::US11466017, Example 130 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 83.0 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384207&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167042 404853492 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767201 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(N)c1Cl 384208 (1R)-8-[3-(3-amino- 2-chlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl]-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 131::US10851110, Example 131::US11466017, Example 131 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 84.0 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384208&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166821 404853493 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767203 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(N)c1Cl InChI=1S/C18H22ClN7/c1-18(10-20)5-7-26(8-6-18)13-9-22-16-15(24-25-17(16)23-13)11-3-2-4-12(21)14(11)19/h2-4,9H,5-8,10,20-21H2,1H3,(H,23,24,25) CKEXLFZOLNCINM-UHFFFAOYSA-N 384209 3-{6-[4-(amino- methyl)-4-methyl- piperidin-1-yl]-1H- pyrazolo[3,4-b]- pyrazin-3-yl}-2- chloroaniline::US10280171, Example 132::US10851110, Example 132::US11466017, Example 132 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 119 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384209&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167049 404853494 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767205 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(N)ncc1Cl InChI=1S/C17H21ClN8/c1-17(9-19)2-4-26(5-3-17)13-8-22-15-14(24-25-16(15)23-13)10-6-12(20)21-7-11(10)18/h6-8H,2-5,9,19H2,1H3,(H2,20,21)(H,23,24,25) PIIJGIPNQPGCJA-UHFFFAOYSA-N 384210 4-{6-[4-(amino- methyl)-4-methyl- piperidin-1-yl]-1H- pyrazolo[3,4-b]- pyrazin-3-yl}-5- chloropyridin-2- amine::US10280171, Example 133::US10851110, Example 133::US11466017, Example 133 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 840 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384210&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166906 404853495 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767207 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(N)ncc1Cl InChI=1S/C16H19ClN8O/c17-10-6-20-11(19)5-9(10)13-14-15(24-23-13)22-12(7-21-14)25-3-1-16(26,8-18)2-4-25/h5-7,26H,1-4,8,18H2,(H2,19,20)(H,22,23,24) ZNZVUWRUFRWPCO-UHFFFAOYSA-N 384211 1-[3-(2-amino-5- chloropyridin-4-yl)- 1H-pyrazolo[3,4-b]- pyrazin-6-yl]-4- (aminomethyl)- piperidin-4-ol::US10280171, Example 134::US10851110, Example 134::US11466017, Example 134 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1532 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384211&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166958 404853496 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767209 CCC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl InChI=1S/C17H21ClN8/c1-2-17(20)4-7-26(8-5-17)11-9-22-14-13(24-25-16(14)23-11)10-3-6-21-15(19)12(10)18/h3,6,9H,2,4-5,7-8,20H2,1H3,(H2,19,21)(H,23,24,25) LVBIHNDCEXHSGZ-UHFFFAOYSA-N 384212 4-[6-(4-amino-4- ethylpiperidin-1-yl)- 1H-pyrazolo[3,4-b]- pyrazin-3-yl]-3- chloropyridin-2- amine::US10280171, Example 135::US10851110, Example 135::US11466017, Example 135 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 529 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384212&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166848 404853497 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767211 NC1CC[C@]11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384213 US10280171, Example 136a::US10280171, Example 136b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 15155 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384213&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166895 404853498 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767213 NC1CC[C@]11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384213 US10280171, Example 136a::US10280171, Example 136b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 4318 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384213&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166895 404853498 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767215 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(N)ncc1Cl 384215 (4S)-8-[3-(2-amino- 5-chloropyridin-4- yl)-1H-pyrazolo[3,4- b]pyrazin-6-yl]-2- oxa-8-azaspiro[4.5]- decan-4-amine::US10280171, Example 137::US10851110, Example 137::US11466017, Example 137 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 504 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384215&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167159 404853499 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767217 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(N)ccc1Cl InChI=1S/C17H20ClN7/c1-17(20)4-6-25(7-5-17)13-9-21-15-14(23-24-16(15)22-13)11-8-10(19)2-3-12(11)18/h2-3,8-9H,4-7,19-20H2,1H3,(H,22,23,24) ABECVSURQGZTBR-UHFFFAOYSA-N 384216 4-[6-(4-amino-4- methylpiperidin-1- yl)-1H-pyrazolo[3,4- b]pyrazin-3-yl]-5- chloropyridin-2- amine::US10280171, Example 138::US10851110, Example 138::US11466017, Example 138 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 587 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384216&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132180687 404853500 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767036 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C17H18Cl2N6/c1-17(20)5-7-25(8-6-17)12-9-21-15-14(23-24-16(15)22-12)10-3-2-4-11(18)13(10)19/h2-4,9H,5-8,20H2,1H3,(H,22,23,24) AMADCPJVPLUGQO-UHFFFAOYSA-N 384117 1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-amine::US10280171, Example 1::US10851110, Example 1::US11466017, Example 1::US11529347, Compound 23 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 110 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384117&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search U9Y 6WU8 132166923 404853403 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767037 Clc1cccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCNC3)CC2)c1Cl InChI=1S/C19H20Cl2N6/c20-13-3-1-2-12(15(13)21)16-17-18(26-25-16)24-14(10-23-17)27-8-5-19(6-9-27)4-7-22-11-19/h1-3,10,22H,4-9,11H2,(H,24,25,26) ISZYHBGNJBUGLA-UHFFFAOYSA-N 384118 8-(3-(2,3-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-2,8- diazaspiro- [4.5]decane::US10280171, Example 2::US10851110, Example 2::US11466017, Example 2 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 787 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384118&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166744 404853404 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767038 N[C@H]1[C@@H]2CN(C[C@H]12)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 384119 (1R,5S,6S)-3-(3-(2,3- dichlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-3-aza- bicyclo[3.1.0]hexan- 6-amine::US10280171, Example 3::US10851110, Example 3::US11466017, Example 3 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1072 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384119&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166986 404853405 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767039 CNC1(C)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C18H20Cl2N6/c1-18(21-2)6-8-26(9-7-18)13-10-22-16-15(24-25-17(16)23-13)11-4-3-5-12(19)14(11)20/h3-5,10,21H,6-9H2,1-2H3,(H,23,24,25) MEDFNRZYVCVZEM-UHFFFAOYSA-N 384120 1-(3-(2,3- Dichlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-N,4- dimethylpiperidin-4- amine::US10280171, Example 6::US10851110, Example 6::US11466017, Example 6 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 2.00 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384120&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166914 404853406 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767040 Clc1cccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCN3)CC2)c1Cl InChI=1S/C18H18Cl2N6/c19-12-3-1-2-11(14(12)20)15-16-17(25-24-15)23-13(10-21-16)26-8-5-18(6-9-26)4-7-22-18/h1-3,10,22H,4-9H2,(H,23,24,25) GBRTUCQWCTVZDK-UHFFFAOYSA-N 384121 3-(2,3-dichloro- phenyl)-6-(1,7-diaza- spiro[3.5]nonan-7- yl)-1H-pyrazolo[3,4- b]pyrazine::US10280171, Example 7::US10851110, Example 7::US11466017, Example 7 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 196 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384121&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166833 404853407 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767042 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C17H18Cl2N6O/c18-11-3-1-2-10(13(11)19)14-15-16(24-23-14)22-12(8-21-15)25-6-4-17(26,9-20)5-7-25/h1-3,8,26H,4-7,9,20H2,(H,22,23,24) CCNVAVIEHMNTEE-UHFFFAOYSA-N 384122 4-(aminomethyl)-1- (3-(2,3-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)- piperidin-4-ol::US10280171, Example 8::US10851110, Example 8::US11466017, Example 8 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 204 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384122&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166826 404853408 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767044 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1 InChI=1S/C18H21ClN6/c1-18(11-20)5-7-25(8-6-18)14-10-21-16-15(23-24-17(16)22-14)12-3-2-4-13(19)9-12/h2-4,9-10H,5-8,11,20H2,1H3,(H,22,23,24) STWOQVDTSIRUNC-UHFFFAOYSA-N 384123 (1-(3-(3-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- yl)methanamine::US10280171, Example 9::US10851110, Example 9::US11529347, Compound 50 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 367 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384123&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166802 404853409 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767046 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1 InChI=1S/C17H19ClN6/c1-17(19)5-7-24(8-6-17)13-10-20-15-14(22-23-16(15)21-13)11-3-2-4-12(18)9-11/h2-4,9-10H,5-8,19H2,1H3,(H,21,22,23) NHGRNRILMHNSIR-UHFFFAOYSA-N 384124 1-(3-(3-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 10::US10851110, Example 10::US11466017, Example 10::US11529347, Compound 31 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 333 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384124&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166907 404853410 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 767048 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(Cl)cc(Cl)c1 InChI=1S/C18H20Cl2N6/c1-18(10-21)2-4-26(5-3-18)14-9-22-16-15(24-25-17(16)23-14)11-6-12(19)8-13(20)7-11/h6-9H,2-5,10,21H2,1H3,(H,23,24,25) RQJVSHGOYHHYSM-UHFFFAOYSA-N 384125 (1-(3-(3,5-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 11::US10851110, Example 11::US11466017, Example 11 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 632 US Patent 10.7270/Q2TH8Q0Z aid1798584 US10280171 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA The University of Texas System http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384125&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167035 404853411 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986247 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccnc1Cl InChI=1S/C17H20ClN7/c1-17(10-19)4-7-25(8-5-17)12-9-21-14-13(23-24-16(14)22-12)11-3-2-6-20-15(11)18/h2-3,6,9H,4-5,7-8,10,19H2,1H3,(H,22,23,24) ACZCNRCVPUGLCW-UHFFFAOYSA-N 384150 (1-(3-(2-chloro- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 36::US10851110, Example 36::US11466017, Example 36 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 967 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384150&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166991 404853436 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986248 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(F)c1Cl InChI=1S/C17H18ClFN6O/c18-13-10(2-1-3-11(13)19)14-15-16(24-23-14)22-12(8-21-15)25-6-4-17(26,9-20)5-7-25/h1-3,8,26H,4-7,9,20H2,(H,22,23,24) YFIASUMJKJCVBV-UHFFFAOYSA-N 384151 4-(Aminomethyl)-1-(3-(2-chloro-3-fluorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-piperidin-4-ol::US10280171, Example 37::US10851110, Example 37::US11466017, Example 37 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 623 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384151&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166812 404853437 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986249 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 384152 (S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2-oxa-8-azaspiro[4.5]-decan-4-amine::US10280171, Example 38::US10851110, Example 38::US11466017, Example 38 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 75.0 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384152&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166974 404853438 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986250 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl 384153 (S)-8-(3-(2-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-2-oxa- 8-azaspiro[4.5]- decan-4-amine::US10280171, Example 39::US10851110, Example 39::US11466017, Example 39 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 158 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384153&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166852 404853439 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986251 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1c(F)cccc1Cl 384154 (4S)-8-(3-(2-Chloro- 6-fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-2-oxa- 8-azaspiro[4.5]- decan-4-amine::US10280171, Example 40::US10851110, Example 40::US11466017, Example 40 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 203 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384154&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167117 404853440 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986252 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccnc1Cl 384155 (S)-8-(3-(2-chloro- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-2-oxa- 8-azaspiro[4.5]- decan-4-amine trifluoroacetate::US10280171, Example 41::US10851110, Example 41::US11466017, Example 41 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 966 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384155&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166850 404853441 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986253 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1 384157 (R)-8-(3-(3-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]-decan-1- amine::US10280171, Example 44::US10851110, Example 44::US11466017, Example 44 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 429 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384157&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166809 404853443 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986254 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(Cl)cc(Cl)c1 384158 (R)-8-(3-(3,5-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 45::US10851110, Example 45::US11466017, Example 45 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 355 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384158&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166912 404853444 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986255 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)c(Cl)c1 384159 (R)-8-(3-(3,4-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 46::US10851110, Example 46::US11466017, Example 46 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 193 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384159&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167057 404853445 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986256 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(F)c(Cl)c1 384160 (R)-8-(3-(3-chloro-4- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 47::US10851110, Example 47::US11466017, Example 47 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 493 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384160&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166800 404853446 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986257 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(c1)C(F)(F)F 384161 (R)-8-(3-(3- (trifluoromethyl)- phenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 48::US10851110, Example 48::US11466017, Example 48 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1756 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384161&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167130 404853447 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986258 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1F 384162 (R)-8-(3-(3-chloro-2- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 49::US10851110, Example 49::US11466017, Example 49 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 143 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384162&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166940 404853448 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986259 COc1cccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCC[C@H]3N)CC2)c1Cl 384163 (R)-8-(3-(2-chloro-3- methoxyphenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 50::US10851110, Example 50::US11466017, Example 50 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 39.0 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384163&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167017 404853449 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986260 Cc1c(Cl)cccc1-c1n[nH]c2nc(cnc12)N1CCC2(CCC[C@H]2N)CC1 384164 (R)-8-(3-(3-chloro-2- methylphenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 51::US10851110, Example 51::US11466017, Example 51 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 153 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384164&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166886 404853450 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986261 COc1cc(Cl)cc(c1)-c1n[nH]c2nc(cnc12)N1CCC2(CCC[C@H]2N)CC1 384165 (R)-8-(3-(3-chloro-5- methoxyphenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 52::US10851110, Example 52::US11466017, Example 52 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 313 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384165&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167063 404853451 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986262 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccnc1Cl 384166 (R)-8-(3-(2-chloro- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8- aza- spiro[4.5]decan-1- amine::US10280171, Example 53::US10851110, Example 56::US11466017, Example 53 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 641 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384166&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166913 404853452 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986263 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl 384167 (R)-8-(3-(2- chlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 54::US10851110, Example 54::US11466017, Example 54::US11529347, Compound 16 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 119 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384167&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167004 404853453 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986264 Cc1ncccc1-c1n[nH]c2nc(cnc12)N1CCC2(CCC[C@H]2N)CC1 384168 (R)-8-(3-(2-methyl- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8- azaspiro[4.5]decan- I -amine::US10280171, Example 55::US10851110, Example 55::US11466017, Example 55 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1143 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384168&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176111 404853454 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986265 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccnc1Cl 384166 (R)-8-(3-(2-chloro- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8- aza- spiro[4.5]decan-1- amine::US10280171, Example 53::US10851110, Example 56::US11466017, Example 53 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 552 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384166&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166913 404853452 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986266 NC1(CO)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C17H18Cl2N6O/c18-11-3-1-2-10(13(11)19)14-15-16(24-23-14)22-12(8-21-15)25-6-4-17(20,9-26)5-7-25/h1-3,8,26H,4-7,9,20H2,(H,22,23,24) YCRNZPYPOFXDCB-UHFFFAOYSA-N 384170 (4-Amino-1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)piperidin-4-yl)-methanol::US10280171, Example 57::US10851110, Example 57::US11466017, Example 57 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 104 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384170&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166807 404853456 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986267 NC1(CF)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C17H17Cl2FN6/c18-11-3-1-2-10(13(11)19)14-15-16(25-24-14)23-12(8-22-15)26-6-4-17(21,9-20)5-7-26/h1-3,8H,4-7,9,21H2,(H,23,24,25) KCRBJSWWABFQLC-UHFFFAOYSA-N 384171 1-(3-(2,3-dichlo- rophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- (fluoromethyl)- piperidin-4-amine::US10280171, Example 58::US10851110, Example 58::US11466017, Example 58 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 338 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384171&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176113 404853457 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986268 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl InChI=1S/C17H19ClN6O/c18-12-4-2-1-3-11(12)14-15-16(23-22-14)21-13(9-20-15)24-7-5-17(25,10-19)6-8-24/h1-4,9,25H,5-8,10,19H2,(H,21,22,23) YMDXJDQSJVLAPR-UHFFFAOYSA-N 384173 4-(aminomethyl)-1- (3-(2-chlorophenyl)- 1H-pyrazolo[3,4-b]- pyrazin-6-yl)- piperidin-4-ol::US10280171, Example 60::US10851110, Example 60::US11466017, Example 60::US11529347, Compound 52 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 918 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384173&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166856 404853459 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986269 NC1(CO)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl InChI=1S/C17H19ClN6O/c18-12-4-2-1-3-11(12)14-15-16(23-22-14)21-13(9-20-15)24-7-5-17(19,10-25)6-8-24/h1-4,9,25H,5-8,10,19H2,(H,21,22,23) DCZHDAUEYSJCLK-UHFFFAOYSA-N 384174 (4-amino-1-(3-(2- chlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)- piperidin-4-yl)- methanol::US10280171, Example 61::US10851110, Example 61::US11529347, Compound 56 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 401 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384174&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166804 404853460 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986270 N[C@H]1[C@@H](F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 475734 8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2-fluoro-8-azaspiro[4.5]decan-1-amine::US10851110, Example 64A Tyrosine-protein phosphatase non-receptor type 11 [E76K] 98.0 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=475734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=475734&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176150 442075803 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986271 N[C@@H]1[C@@H](F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 475735 US10851110, Example 64B::US11466017, Example 64B Tyrosine-protein phosphatase non-receptor type 11 [E76K] 221 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=475735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=475735&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176151 442075804 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986272 N[C@@H]1C(F)(F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 475736 8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2,2-difluoro-8-azaspiro[4.5]decan-1-amine::US10851110, Example 65A::US11466017, Example 65A Tyrosine-protein phosphatase non-receptor type 11 [E76K] 235 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=475736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=475736&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 156023091 442075805 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986273 N[C@H]1C(F)(F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 475737 US10851110, Example 65B::US11466017, Example 65B Tyrosine-protein phosphatase non-receptor type 11 [E76K] 471 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=475737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=475737&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132180718 442075806 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986274 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cn[nH]c1C(F)(F)F InChI=1S/C15H15F3N8/c1-14(19)2-4-26(5-3-14)9-7-20-11-10(23-25-13(11)22-9)8-6-21-24-12(8)15(16,17)18/h6-7H,2-5,19H2,1H3/b10-8- KZPBYVFZYXDAKG-NTMALXAHSA-N 384181 4-Methyl-1-(3-(5-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-piperidin-4-amine::US10280171, Example 101::US10851110, Example 101::US11466017, Example 101 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1894 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384181&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166754 404853466 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986275 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cn[nH]c1C(F)(F)F InChI=1S/C18H19F3N8/c19-18(20,21)15-10(8-24-27-15)13-14-16(28-26-13)25-12(9-23-14)29-6-4-17(5-7-29)3-1-2-11(17)22/h8-9,11H,1-7,22H2/b13-10-/t11-/m1/s1 JQQQFWFXYNBFCC-COVOJHCQSA-N 384182 (R)-8-(3-(5-(Trifluoromethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-1-amine::US10280171, Example 102::US10851110, Example 102::US11466017, Example 102 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 2154 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384182&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166930 404853467 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986276 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cn[nH]c1C(F)(F)F InChI=1S/C16H17F3N8/c1-15(8-20)2-4-27(5-3-15)10-7-21-12-11(24-26-14(12)23-10)9-6-22-25-13(9)16(17,18)19/h6-7H,2-5,8,20H2,1H3/b11-9- ZFBUAYQZKUQVSN-LUAWRHEFSA-N 384183 (R)-8-(3-(5-(Trifluoromethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-1-amine::US10280171, Example 103::US10851110, Example 103::US11466017, Example 103 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 2603 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384183&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166827 404853468 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986277 CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC(C)(CN)CC2)c1Cl InChI=1S/C18H23ClN8/c1-18(10-20)4-7-27(8-5-18)12-9-23-15-14(25-26-17(15)24-12)11-3-6-22-16(21-2)13(11)19/h3,6,9H,4-5,7-8,10,20H2,1-2H3,(H,21,22)(H,24,25,26) WCBNKFWTMBJQOT-UHFFFAOYSA-N 384184 4-(6-(4-(Aminomethyl)-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloro-N-methylpyridin-2-amine::US10280171, Example 104::US10851110, Example 104::US11466017, Example 104 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 99.0 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384184&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167058 404853469 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986278 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(N)c1Cl InChI=1S/C17H20ClN7/c1-17(20)5-7-25(8-6-17)12-9-21-15-14(23-24-16(15)22-12)10-3-2-4-11(19)13(10)18/h2-4,9H,5-8,19-20H2,1H3,(H,22,23,24) QUZYGWHMIMOARM-UHFFFAOYSA-N 384185 1-(3-(3-amino-2-chlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-amine::US10280171, Example 105::US10851110, Example 105::US11466017, Example 105 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 191 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384185&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166876 404853470 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986279 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl InChI=1S/C16H19ClN8/c1-16(19)3-6-25(7-4-16)10-8-21-13-12(23-24-15(13)22-10)9-2-5-20-14(18)11(9)17/h2,5,8H,3-4,6-7,19H2,1H3,(H2,18,20)(H,22,23,24) ZSNQCYQABMACIK-UHFFFAOYSA-N 384186 4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-3-chloropyridin-2-amine::US10280171, Example 106::US10851110, Example 106::US11466017, Example 106 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 253 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384186&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166751 404853471 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986280 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl InChI=1S/C17H21ClN8/c1-17(9-19)3-6-26(7-4-17)11-8-22-14-13(24-25-16(14)23-11)10-2-5-21-15(20)12(10)18/h2,5,8H,3-4,6-7,9,19H2,1H3,(H2,20,21)(H,23,24,25) POYNJTHRRZRCMC-UHFFFAOYSA-N 384187 4-(6-(4-(Aminomethyl)-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-amine::US10280171, Example 107::US10851110, Example 107::US11466017, Example 107 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 162 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384187&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167030 404853472 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986281 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl 384188 4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-amine::US10280171, Example 108::US10851110, Example 108::US11466017, Example 108 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 726 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384188&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166878 404853473 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986282 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl 384189 (S)-4-(6-(4-Amino-2-oxa-8-azaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-ol::US10280171, Example 109::US10851110, Example 109::US11466017, Example 109 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1095 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384189&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166793 404853474 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986283 NC1(CO)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl InChI=1S/C16H18ClN7O2/c17-11-9(1-4-19-15(11)26)12-13-14(23-22-12)21-10(7-20-13)24-5-2-16(18,8-25)3-6-24/h1,4,7,25H,2-3,5-6,8,18H2,(H,19,26)(H,21,22,23) GZGWPZGIPUFBJS-UHFFFAOYSA-N 384190 4-(6-(4-Amino-4-(hydroxymethyl)piperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-ol::US10280171, Example 110::US10851110, Example 110::US11466017, Example 110 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 3679 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384190&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166946 404853475 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986284 CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCC[C@H]3N)CC2)c1Cl 384191 (R)-8-(3-(3-Chloro-2-(methylamino)pyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-1-amine::US10280171, Example 111::US10851110, Example 111::US11466017, Example 111 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 43.0 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384191&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166783 404853476 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986285 CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC(C)(N)CC2)c1Cl InChI=1S/C17H21ClN8/c1-17(19)4-7-26(8-5-17)11-9-22-14-13(24-25-16(14)23-11)10-3-6-21-15(20-2)12(10)18/h3,6,9H,4-5,7-8,19H2,1-2H3,(H,20,21)(H,23,24,25) XLKDUTBYZJONNW-UHFFFAOYSA-N 384192 4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloro-N-methylpyridin-2-amine::US10280171, Example 112::US10851110, Example 112::US11466017, Example 112 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 128 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384192&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 37I 7R7D 132166808 404853477 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986286 CC(N)C1(C)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 475750 US10851110, Example 113a Tyrosine-protein phosphatase non-receptor type 11 [E76K] 180 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=475750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=475750&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166942 442075819 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986287 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl InChI=1S/C16H19ClN8O/c17-11-9(1-4-20-14(11)19)12-13-15(24-23-12)22-10(7-21-13)25-5-2-16(26,8-18)3-6-25/h1,4,7,26H,2-3,5-6,8,18H2,(H2,19,20)(H,22,23,24) QJPILDDCQKPWJV-UHFFFAOYSA-N 384194 1-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-(aminomethyl)piperidin-4-ol::US10280171, Example 114::US10851110, Example 114::US11466017, Example 114 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 779 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384194&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166791 404853479 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986288 NC1CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384195 7-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-7-azaspiro[3.5]nonan-1-amine::US10280171, Example 115::US10851110, Example 136b::US11466017, Example 115 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 701 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384195&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166895 404853480 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986289 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384196 (S)-8-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2-oxa-8-azaspiro[4.5]decan-4-amine::US10280171, Example 116::US10851110, Example 116::US11466017, Example 116 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 132 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384196&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167093 404853481 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986290 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl InChI=1S/C16H18ClN7O/c1-16(18)3-6-24(7-4-16)10-8-20-13-12(22-23-14(13)21-10)9-2-5-19-15(25)11(9)17/h2,5,8H,3-4,6-7,18H2,1H3,(H,19,25)(H,21,22,23) DVTOAVZTUJPMMJ-UHFFFAOYSA-N 384197 4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-ol::US10280171, Example 117::US10851110, Example 117::US11466017, Example 117 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1941 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384197&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166752 404853482 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986291 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl InChI=1S/C17H20ClN7O/c1-17(9-19)3-6-25(7-4-17)11-8-21-14-13(23-24-15(14)22-11)10-2-5-20-16(26)12(10)18/h2,5,8H,3-4,6-7,9,19H2,1H3,(H,20,26)(H,22,23,24) NRGYUJKDKQWLQO-UHFFFAOYSA-N 384198 1-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4(aminomethyl)piperidin-4-ol::US10280171, Example 118::US10851110, Example 118::US11466017, Example 118 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1128 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384198&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166938 404853483 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986292 Nc1nccc(-c2n[nH]c3nc(cnc23)N2CCC(N)(CO)CC2)c1Cl InChI=1S/C16H19ClN8O/c17-11-9(1-4-20-14(11)18)12-13-15(24-23-12)22-10(7-21-13)25-5-2-16(19,8-26)3-6-25/h1,4,7,26H,2-3,5-6,8,19H2,(H2,18,20)(H,22,23,24) QPRIEZJKJCCITA-UHFFFAOYSA-N 384199 (4-Amino-1-(3-(2-amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-piperidin-4-yl)methanol::US10280171, Example 119::US10851110, Example 119::US11466017, Example 119 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 422 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384199&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167100 404853484 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986293 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl InChI=1S/C16H18ClN7O2/c17-11-9(1-4-19-15(11)25)12-13-14(23-22-12)21-10(7-20-13)24-5-2-16(26,8-18)3-6-24/h1,4,7,26H,2-3,5-6,8,18H2,(H,19,25)(H,21,22,23) GVSONOQWYKOEOK-UHFFFAOYSA-N 384200 4-(6-(4-(Aminomethyl)-4-hydroxypiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-ol::US10280171, Example 120::US10851110, Example 120::US11466017, Example 120 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 5372 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384200&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166893 404853485 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986294 NC1(CO)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1c(F)cccc1Cl InChI=1S/C17H18ClFN6O/c18-10-2-1-3-11(19)13(10)14-15-16(24-23-14)22-12(8-21-15)25-6-4-17(20,9-26)5-7-25/h1-3,8,26H,4-7,9,20H2,(H,22,23,24) ZECYCODHSVTEAW-UHFFFAOYSA-N 384201 (4-Amino-1-(3-(2-chloro-6-fluorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-piperidin-4-yl)methanol::US10280171, Example 121::US10851110, Example 121::US11466017, Example 121 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1083 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384201&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166873 404853486 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986295 Cc1c(N)nccc1-c1n[nH]c2nc(cnc12)N1CCC2(CCC[C@H]2N)CC1 475759 3-(2,3-Dichlorophenyl)-6-(2,8-diazaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-b]pyrazine::US10851110, Example 122::US11466017, Example 122 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 205 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=475759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=475759&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167140 442075828 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986296 Cc1c(N)nccc1-c1n[nH]c2nc(cnc12)N1CCC(C)(N)CC1 InChI=1S/C17H22N8/c1-10-11(3-6-20-15(10)18)13-14-16(24-23-13)22-12(9-21-14)25-7-4-17(2,19)5-8-25/h3,6,9H,4-5,7-8,19H2,1-2H3,(H2,18,20)(H,22,23,24) DMNYIHIRUJAKGX-UHFFFAOYSA-N 384203 4-(6-(4-amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-methylpyridin-2-amine::US10280171, Example 123::US10851110, Example 123::US11466017, Example 123 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 670 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384203&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166867 404853488 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986297 Cc1c(N)nccc1-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 InChI=1S/C18H24N8/c1-11-12(3-6-21-16(11)20)14-15-17(25-24-14)23-13(9-22-15)26-7-4-18(2,10-19)5-8-26/h3,6,9H,4-5,7-8,10,19H2,1-2H3,(H2,20,21)(H,23,24,25) LLWQCPSJCBXVHN-UHFFFAOYSA-N 384204 4-(6-(4-(Aminomethyl)-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-methylpyridin-2-amine::US10280171, Example 124::US10851110, Example 124::US11466017, Example 124 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 377 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384204&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167121 404853489 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986298 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(N)ncc1Cl 384205 (R)-8-(3-(2-amino-5-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-1-amine::US10280171, Example 125::US10851110, Example 125::US11466017, Example 125 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 509 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384205&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166759 404853490 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986299 N[C@@H]1C[C@@H](O)CC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384206 (2S,4R)-4-Amino-8-(3-(2-amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-2-ol::US10280171, Example 126::US10851110, Example 126::US11466017, Example 126 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 75.0 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384206&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166963 404853491 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986300 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384207 (1R)-8-[3-(2-amino- 3-chloropyridin-4- yl)-1H-pyrazolo[3,4- b]pyrazin-6-yl]-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 130::US10851110, Example 130::US11466017, Example 130 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 83.0 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384207&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167042 404853492 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986301 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(N)c1Cl 384208 (1R)-8-[3-(3-amino- 2-chlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl]-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 131::US10851110, Example 131::US11466017, Example 131 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 84.0 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384208&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166821 404853493 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986302 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(N)c1Cl InChI=1S/C18H22ClN7/c1-18(10-20)5-7-26(8-6-18)13-9-22-16-15(24-25-17(16)23-13)11-3-2-4-12(21)14(11)19/h2-4,9H,5-8,10,20-21H2,1H3,(H,23,24,25) CKEXLFZOLNCINM-UHFFFAOYSA-N 384209 3-{6-[4-(amino- methyl)-4-methyl- piperidin-1-yl]-1H- pyrazolo[3,4-b]- pyrazin-3-yl}-2- chloroaniline::US10280171, Example 132::US10851110, Example 132::US11466017, Example 132 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 119 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384209&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167049 404853494 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986303 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(N)ncc1Cl InChI=1S/C17H21ClN8/c1-17(9-19)2-4-26(5-3-17)13-8-22-15-14(24-25-16(15)23-13)10-6-12(20)21-7-11(10)18/h6-8H,2-5,9,19H2,1H3,(H2,20,21)(H,23,24,25) PIIJGIPNQPGCJA-UHFFFAOYSA-N 384210 4-{6-[4-(amino- methyl)-4-methyl- piperidin-1-yl]-1H- pyrazolo[3,4-b]- pyrazin-3-yl}-5- chloropyridin-2- amine::US10280171, Example 133::US10851110, Example 133::US11466017, Example 133 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 840 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384210&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166906 404853495 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986304 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(N)ncc1Cl InChI=1S/C16H19ClN8O/c17-10-6-20-11(19)5-9(10)13-14-15(24-23-13)22-12(7-21-14)25-3-1-16(26,8-18)2-4-25/h5-7,26H,1-4,8,18H2,(H2,19,20)(H,22,23,24) ZNZVUWRUFRWPCO-UHFFFAOYSA-N 384211 1-[3-(2-amino-5- chloropyridin-4-yl)- 1H-pyrazolo[3,4-b]- pyrazin-6-yl]-4- (aminomethyl)- piperidin-4-ol::US10280171, Example 134::US10851110, Example 134::US11466017, Example 134 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1532 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384211&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166958 404853496 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986305 CCC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl InChI=1S/C17H21ClN8/c1-2-17(20)4-7-26(8-5-17)11-9-22-14-13(24-25-16(14)23-11)10-3-6-21-15(19)12(10)18/h3,6,9H,2,4-5,7-8,20H2,1H3,(H2,19,21)(H,23,24,25) LVBIHNDCEXHSGZ-UHFFFAOYSA-N 384212 4-[6-(4-amino-4- ethylpiperidin-1-yl)- 1H-pyrazolo[3,4-b]- pyrazin-3-yl]-3- chloropyridin-2- amine::US10280171, Example 135::US10851110, Example 135::US11466017, Example 135 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 529 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384212&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166848 404853497 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986306 NC1CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384195 7-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-7-azaspiro[3.5]nonan-1-amine::US10280171, Example 115::US10851110, Example 136b::US11466017, Example 115 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 15155 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384195&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166895 404853480 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986307 NC1CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384195 7-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-7-azaspiro[3.5]nonan-1-amine::US10280171, Example 115::US10851110, Example 136b::US11466017, Example 115 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 4318 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384195&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166895 404853480 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986308 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(N)ncc1Cl 384215 (4S)-8-[3-(2-amino- 5-chloropyridin-4- yl)-1H-pyrazolo[3,4- b]pyrazin-6-yl]-2- oxa-8-azaspiro[4.5]- decan-4-amine::US10280171, Example 137::US10851110, Example 137::US11466017, Example 137 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 504 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384215&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167159 404853499 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986309 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(N)ccc1Cl InChI=1S/C17H20ClN7/c1-17(20)4-6-25(7-5-17)13-9-21-15-14(23-24-16(15)22-13)11-8-10(19)2-3-12(11)18/h2-3,8-9H,4-7,19-20H2,1H3,(H,22,23,24) ABECVSURQGZTBR-UHFFFAOYSA-N 384216 4-[6-(4-amino-4- methylpiperidin-1- yl)-1H-pyrazolo[3,4- b]pyrazin-3-yl]-5- chloropyridin-2- amine::US10280171, Example 138::US10851110, Example 138::US11466017, Example 138 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 587 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384216&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132180687 404853500 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986215 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C17H18Cl2N6/c1-17(20)5-7-25(8-6-17)12-9-21-15-14(23-24-16(15)22-12)10-3-2-4-11(18)13(10)19/h2-4,9H,5-8,20H2,1H3,(H,22,23,24) AMADCPJVPLUGQO-UHFFFAOYSA-N 384117 1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-amine::US10280171, Example 1::US10851110, Example 1::US11466017, Example 1::US11529347, Compound 23 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 110 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384117&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search U9Y 6WU8 132166923 404853403 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986216 Clc1cccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCNC3)CC2)c1Cl InChI=1S/C19H20Cl2N6/c20-13-3-1-2-12(15(13)21)16-17-18(26-25-16)24-14(10-23-17)27-8-5-19(6-9-27)4-7-22-11-19/h1-3,10,22H,4-9,11H2,(H,24,25,26) ISZYHBGNJBUGLA-UHFFFAOYSA-N 384118 8-(3-(2,3-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-2,8- diazaspiro- [4.5]decane::US10280171, Example 2::US10851110, Example 2::US11466017, Example 2 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 787 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384118&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166744 404853404 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986217 N[C@H]1[C@@H]2CN(C[C@H]12)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 384119 (1R,5S,6S)-3-(3-(2,3- dichlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-3-aza- bicyclo[3.1.0]hexan- 6-amine::US10280171, Example 3::US10851110, Example 3::US11466017, Example 3 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1072 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384119&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166986 404853405 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986218 CNC1(C)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C18H20Cl2N6/c1-18(21-2)6-8-26(9-7-18)13-10-22-16-15(24-25-17(16)23-13)11-4-3-5-12(19)14(11)20/h3-5,10,21H,6-9H2,1-2H3,(H,23,24,25) MEDFNRZYVCVZEM-UHFFFAOYSA-N 384120 1-(3-(2,3- Dichlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-N,4- dimethylpiperidin-4- amine::US10280171, Example 6::US10851110, Example 6::US11466017, Example 6 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 2.00 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384120&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166914 404853406 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986219 Clc1cccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCN3)CC2)c1Cl InChI=1S/C18H18Cl2N6/c19-12-3-1-2-11(14(12)20)15-16-17(25-24-15)23-13(10-21-16)26-8-5-18(6-9-26)4-7-22-18/h1-3,10,22H,4-9H2,(H,23,24,25) GBRTUCQWCTVZDK-UHFFFAOYSA-N 384121 3-(2,3-dichloro- phenyl)-6-(1,7-diaza- spiro[3.5]nonan-7- yl)-1H-pyrazolo[3,4- b]pyrazine::US10280171, Example 7::US10851110, Example 7::US11466017, Example 7 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 196 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384121&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166833 404853407 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986220 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C17H18Cl2N6O/c18-11-3-1-2-10(13(11)19)14-15-16(24-23-14)22-12(8-21-15)25-6-4-17(26,9-20)5-7-25/h1-3,8,26H,4-7,9,20H2,(H,22,23,24) CCNVAVIEHMNTEE-UHFFFAOYSA-N 384122 4-(aminomethyl)-1- (3-(2,3-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)- piperidin-4-ol::US10280171, Example 8::US10851110, Example 8::US11466017, Example 8 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 204 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384122&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166826 404853408 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986221 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1 InChI=1S/C18H21ClN6/c1-18(11-20)5-7-25(8-6-18)14-10-21-16-15(23-24-17(16)22-14)12-3-2-4-13(19)9-12/h2-4,9-10H,5-8,11,20H2,1H3,(H,22,23,24) STWOQVDTSIRUNC-UHFFFAOYSA-N 384123 (1-(3-(3-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- yl)methanamine::US10280171, Example 9::US10851110, Example 9::US11529347, Compound 50 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 367 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384123&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166802 404853409 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986222 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1 InChI=1S/C17H19ClN6/c1-17(19)5-7-24(8-6-17)13-10-20-15-14(22-23-16(15)21-13)11-3-2-4-12(18)9-11/h2-4,9-10H,5-8,19H2,1H3,(H,21,22,23) NHGRNRILMHNSIR-UHFFFAOYSA-N 384124 1-(3-(3-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 10::US10851110, Example 10::US11466017, Example 10::US11529347, Compound 31 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 333 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384124&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166907 404853410 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986223 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(Cl)cc(Cl)c1 InChI=1S/C18H20Cl2N6/c1-18(10-21)2-4-26(5-3-18)14-9-22-16-15(24-25-17(16)23-14)11-6-12(19)8-13(20)7-11/h6-9H,2-5,10,21H2,1H3,(H,23,24,25) RQJVSHGOYHHYSM-UHFFFAOYSA-N 384125 (1-(3-(3,5-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 11::US10851110, Example 11::US11466017, Example 11 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 632 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384125&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167035 404853411 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986224 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(Cl)cc(Cl)c1 InChI=1S/C17H18Cl2N6/c1-17(20)2-4-25(5-3-17)13-9-21-15-14(23-24-16(15)22-13)10-6-11(18)8-12(19)7-10/h6-9H,2-5,20H2,1H3,(H,22,23,24) ZLSAGPLZHAPKDO-UHFFFAOYSA-N 384126 1-(3-(3,5-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 12::US10851110, Example 12::US11466017, Example 12 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 404 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384126&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166892 404853412 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986225 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C18H20Cl2N6/c1-18(10-21)4-6-26(7-5-18)14-9-22-16-15(24-25-17(16)23-14)11-2-3-12(19)13(20)8-11/h2-3,8-9H,4-7,10,21H2,1H3,(H,23,24,25) LJXXZVLIMZSWLE-UHFFFAOYSA-N 384127 (1-(3-(3,4-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 13::US10851110, Example 13::US11466017, Example 13 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 158 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384127&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167147 404853413 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986226 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(F)c(Cl)c1 InChI=1S/C18H20ClFN6/c1-18(10-21)4-6-26(7-5-18)14-9-22-16-15(24-25-17(16)23-14)11-2-3-13(20)12(19)8-11/h2-3,8-9H,4-7,10,21H2,1H3,(H,23,24,25) HXKDFUSJAFLWKF-UHFFFAOYSA-N 384128 (1-(3-(3-Chloro-4- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 14::US10851110, Example 14::US11466017, Example 14 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 521 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384128&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166905 404853414 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986227 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)cc1 InChI=1S/C17H19ClN6/c1-17(19)6-8-24(9-7-17)13-10-20-15-14(22-23-16(15)21-13)11-2-4-12(18)5-3-11/h2-5,10H,6-9,19H2,1H3,(H,21,22,23) MGGGLWKKMYVXPD-UHFFFAOYSA-N 384129 1-(3-(4-Chlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-amine::US10280171, Example 15::US10851110, Example 15::US11466017, Example 15::US11529347, Compound 17 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 140 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384129&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166901 404853415 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986228 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)cc1 InChI=1S/C18H21ClN6/c1-18(11-20)6-8-25(9-7-18)14-10-21-16-15(23-24-17(16)22-14)12-2-4-13(19)5-3-12/h2-5,10H,6-9,11,20H2,1H3,(H,22,23,24) BHDQDMSKLZFAOP-UHFFFAOYSA-N 384130 (1-(3-(4-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin- methanamine::US10280171, Example 16::US10851110, Example 16::US11466017, Example 16::US11529347, Compound 29 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 169 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384130&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176105 404853416 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986229 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)cc1 384131 (R)-8-(3-(4-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 17::US10851110, Example 17 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 118 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384131&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166931 404853417 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986230 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C17H18Cl2N6/c1-17(20)4-6-25(7-5-17)13-9-21-15-14(23-24-16(15)22-13)10-2-3-11(18)12(19)8-10/h2-3,8-9H,4-7,20H2,1H3,(H,22,23,24) IEUPVYYCTFCLTF-UHFFFAOYSA-N 384132 1-(3-(3,4-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 18::US10851110, Example 18::US11466017, Example 18 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 141 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384132&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167085 404853418 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986231 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(F)c(Cl)c1 InChI=1S/C17H18ClFN6/c1-17(20)4-6-25(7-5-17)13-9-21-15-14(23-24-16(15)22-13)10-2-3-12(19)11(18)8-10/h2-3,8-9H,4-7,20H2,1H3,(H,22,23,24) HILFUTGZGNSLCF-UHFFFAOYSA-N 384133 1-(3-(3-Chloro-4- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 19::US10851110, Example 19::US11466017, Example 19 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 510 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384133&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166896 404853419 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986232 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl InChI=1S/C17H19ClN6/c1-17(19)6-8-24(9-7-17)13-10-20-15-14(22-23-16(15)21-13)11-4-2-3-5-12(11)18/h2-5,10H,6-9,19H2,1H3,(H,21,22,23) JQWPQEJDTUKOCS-UHFFFAOYSA-N 384134 1-(3-(2- Chlorophenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 20::US10851110, Example 20::US11466017, Example 20::US11529347, Compound 6 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 326 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384134&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167115 404853420 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986233 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(c1)C(F)(F)F InChI=1S/C18H19F3N6/c1-17(22)5-7-27(8-6-17)13-10-23-15-14(25-26-16(15)24-13)11-3-2-4-12(9-11)18(19,20)21/h2-4,9-10H,5-8,22H2,1H3,(H,24,25,26) UCVNJKUCRRXAMU-UHFFFAOYSA-N 384135 4-Methyl-1-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)piperidin-4-amine::US10280171, Example 21::US10851110, Example 21::US11466017, Example 21 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 956 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384135&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166903 404853421 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986234 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(c1)C(F)(F)F InChI=1S/C19H21F3N6/c1-18(11-23)5-7-28(8-6-18)14-10-24-16-15(26-27-17(16)25-14)12-3-2-4-13(9-12)19(20,21)22/h2-4,9-10H,5-8,11,23H2,1H3,(H,25,26,27) VBWUNPVCLSZAAP-UHFFFAOYSA-N 384136 (4-methyl-1-(3-(3- (trifluoromethyl)- phenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)- piperidin-4-yl)- methanamine::US10280171, Example 22::US10851110, Example 22::US11466017, Example 22 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1747 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384136&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167094 404853422 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986235 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccnc1Cl InChI=1S/C16H18ClN7/c1-16(18)4-7-24(8-5-16)11-9-20-13-12(22-23-15(13)21-11)10-3-2-6-19-14(10)17/h2-3,6,9H,4-5,7-8,18H2,1H3,(H,21,22,23) KUMMBNPRGBFMLN-UHFFFAOYSA-N 384137 1-(3-(2-chloro- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methyl-piperidin-4- amine::US10280171, Example 23::US10851110, Example 23::US11466017, Example 23 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1824 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384137&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166863 404853423 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986236 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(F)c1Cl InChI=1S/C17H18ClFN6/c1-17(20)5-7-25(8-6-17)12-9-21-15-14(23-24-16(15)22-12)10-3-2-4-11(19)13(10)18/h2-4,9H,5-8,20H2,1H3,(H,22,23,24) QKNOZCPUZKQEHX-UHFFFAOYSA-N 384138 1-(3-(2-chloro-3- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methyl-piperidin-4- amine::US10280171, Example 24::US10851110, Example 24::US11466017, Example 24 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 204 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384138&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166810 404853424 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986237 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1F InChI=1S/C18H20ClFN6/c1-18(10-21)5-7-26(8-6-18)13-9-22-16-15(24-25-17(16)23-13)11-3-2-4-12(19)14(11)20/h2-4,9H,5-8,10,21H2,1H3,(H,23,24,25) CUTMOOSDQSRDHK-UHFFFAOYSA-N 384139 (1-(3-(3-Chloro-2-fluorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)-methanamine::US10280171, Example 25::US10851110, Example 25::US11466017, Example 25::US11529347, Compound 48 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 101 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384139&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166994 404853425 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986238 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1F InChI=1S/C17H18ClFN6/c1-17(20)5-7-25(8-6-17)12-9-21-15-14(23-24-16(15)22-12)10-3-2-4-11(18)13(10)19/h2-4,9H,5-8,20H2,1H3,(H,22,23,24) QROQTLNVCIGXBV-UHFFFAOYSA-N 384140 1-(3-(3-chloro-2- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 26::US10851110, Example 26::US11466017, Example 26::US11529347, Compound 7 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 213 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384140&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166959 404853426 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986239 COc1cccc(-c2n[nH]c3nc(cnc23)N2CCC(C)(CN)CC2)c1Cl InChI=1S/C19H23ClN6O/c1-19(11-21)6-8-26(9-7-19)14-10-22-17-16(24-25-18(17)23-14)12-4-3-5-13(27-2)15(12)20/h3-5,10H,6-9,11,21H2,1-2H3,(H,23,24,25) NQCYZSVEYSASFG-UHFFFAOYSA-N 384141 (1-(3-(2-chloro-3- methoxy phenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 27::US10851110, Example 27::US11466017, Example 27::US11529347, Compound 39 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 80.0 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384141&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166928 404853427 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986240 Cc1c(Cl)cccc1-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 InChI=1S/C19H23ClN6/c1-12-13(4-3-5-14(12)20)16-17-18(25-24-16)23-15(10-22-17)26-8-6-19(2,11-21)7-9-26/h3-5,10H,6-9,11,21H2,1-2H3,(H,23,24,25) DEVINZPHNDARNY-UHFFFAOYSA-N 384142 (1-(3-(3-chloro-2- methylphenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 28::US10851110, Example 28::US11466017, Example 28 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 142 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384142&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166891 404853428 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986241 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl InChI=1S/C18H21ClN6/c1-18(11-20)6-8-25(9-7-18)14-10-21-16-15(23-24-17(16)22-14)12-4-2-3-5-13(12)19/h2-5,10H,6-9,11,20H2,1H3,(H,22,23,24) JCYHCBVXAFUBRD-UHFFFAOYSA-N 384143 (1-(3-(2-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin- methanamine::US10280171, Example 29::US10851110, Example 29::US11466017, Example 29::US11529347, Compound 43 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 178 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384143&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176109 404853429 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986242 Cc1ncccc1-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 InChI=1S/C18H23N7/c1-12-13(4-3-7-20-12)15-16-17(24-23-15)22-14(10-21-16)25-8-5-18(2,11-19)6-9-25/h3-4,7,10H,5-6,8-9,11,19H2,1-2H3,(H,22,23,24) UJEPRQRVJYIQTG-UHFFFAOYSA-N 384144 (4-methyl-1-(3-(2- methylpyridin-3-yl)- 1H-pyrazolo[3,4- b]pyrazin-6-yl)- piperidin-4-yl) methanamine::US10280171, Example 30::US10851110, Example 30::US11466017, Example 30 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 2509 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384144&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166785 404853430 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986243 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccncc1Cl InChI=1S/C17H20ClN7/c1-17(10-19)3-6-25(7-4-17)13-9-21-15-14(23-24-16(15)22-13)11-2-5-20-8-12(11)18/h2,5,8-9H,3-4,6-7,10,19H2,1H3,(H,22,23,24) HZYUNIMXNROZHD-UHFFFAOYSA-N 384145 (1-(3-(3-chloro- pyridin-4-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 31::US10851110, Example 31::US11466017, Example 31 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 929 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384145&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167009 404853431 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986244 COc1cc(ccc1Cl)-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 InChI=1S/C19H23ClN6O/c1-19(11-21)5-7-26(8-6-19)15-10-22-17-16(24-25-18(17)23-15)12-3-4-13(20)14(9-12)27-2/h3-4,9-10H,5-8,11,21H2,1-2H3,(H,23,24,25) XEMDEEZOTNHZCZ-UHFFFAOYSA-N 384147 (1-(3-(4-Chloro-3-methoxyphenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)methanamine::US10280171, Example 33::US10851110, Example 33::US11466017, Example 33 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 72.0 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384147&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166819 404853433 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986245 COc1cc(ccc1Cl)-c1n[nH]c2nc(cnc12)N1CCC2(CCC[C@H]2N)CC1 384148 (R)-8-(3-(4-chloro-3- methoxyphenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 34::US10851110, Example 34::US11466017, Example 34 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 102 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384148&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166932 404853434 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 986246 COc1cc(Cl)cc(c1)-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 InChI=1S/C19H23ClN6O/c1-19(11-21)3-5-26(6-4-19)15-10-22-17-16(24-25-18(17)23-15)12-7-13(20)9-14(8-12)27-2/h7-10H,3-6,11,21H2,1-2H3,(H,23,24,25) ZXABOENZJMEVQC-UHFFFAOYSA-N 384149 (1-(3-(3-chloro-5- methoxyphenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 35::US10851110, Example 35::US11466017, Example 35 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 304 US Patent 10.7270/Q2833W4T aid1805096 US10851110 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, CA BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384149&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167103 404853435 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015531 Cc1nc2c(n[nH]c2nc1N1CCC(C)(N)CC1)-c1cccc(Cl)c1Cl InChI=1S/C18H20Cl2N6/c1-10-17(26-8-6-18(2,21)7-9-26)23-16-15(22-10)14(24-25-16)11-4-3-5-12(19)13(11)20/h3-5H,6-9,21H2,1-2H3,(H,23,24,25) CQQHMMRMSHDXRX-UHFFFAOYSA-N 488470 US10954243, Example 1 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 68.0 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488470&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 147272133 444858418 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015532 CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1Br InChI=1S/C17H17BrCl2N6/c1-17(21)5-7-26(8-6-17)16-14(18)22-13-12(24-25-15(13)23-16)9-3-2-4-10(19)11(9)20/h2-4H,5-8,21H2,1H3,(H,23,24,25) BTSAJGLYIXMGIP-UHFFFAOYSA-N 488471 US10954243, Example 2 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 317 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488471&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 147149449 444858419 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015533 CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1O InChI=1S/C17H18Cl2N6O/c1-17(20)5-7-25(8-6-17)15-16(26)21-13-12(23-24-14(13)22-15)9-3-2-4-10(18)11(9)19/h2-4H,5-8,20H2,1H3,(H,21,26)(H,22,23,24) VTRXMYATXKKBOG-UHFFFAOYSA-N 488472 US10954243, Example 3 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 960 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488472&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 153300164 444858420 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015534 CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1C#N InChI=1S/C18H17Cl2N7/c1-18(22)5-7-27(8-6-18)17-12(9-21)23-15-14(25-26-16(15)24-17)10-3-2-4-11(19)13(10)20/h2-4H,5-8,22H2,1H3,(H,24,25,26) RCCLQQOJFUVABY-UHFFFAOYSA-N 488473 US10954243, Example 4 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 465 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488473&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 149129496 444858421 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015535 CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1-c1cc[nH]n1 InChI=1S/C20H20Cl2N8/c1-20(23)6-9-30(10-7-20)19-16(13-5-8-24-27-13)25-17-15(28-29-18(17)26-19)11-3-2-4-12(21)14(11)22/h2-5,8H,6-7,9-10,23H2,1H3,(H,24,27)(H,26,28,29) BOYPUJWDPXPKCY-UHFFFAOYSA-N 488474 US10954243, Example 5 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 397 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488474&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 153300182 444858422 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015536 COc1nc2c(n[nH]c2nc1N1CCC(C)(N)CC1)-c1cccc(Cl)c1Cl InChI=1S/C18H20Cl2N6O/c1-18(21)6-8-26(9-7-18)16-17(27-2)22-14-13(24-25-15(14)23-16)10-4-3-5-11(19)12(10)20/h3-5H,6-9,21H2,1-2H3,(H,23,24,25) AANMTIFRLSWMDS-UHFFFAOYSA-N 488475 US10954243, Example 6 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 950 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488475&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 153300197 444858423 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015537 CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1CO InChI=1S/C18H20Cl2N6O/c1-18(21)5-7-26(8-6-18)17-12(9-27)22-15-14(24-25-16(15)23-17)10-3-2-4-11(19)13(10)20/h2-4,27H,5-9,21H2,1H3,(H,23,24,25) AADWCOFHEINTKB-UHFFFAOYSA-N 488476 US10954243, Example 7 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 19.0 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488476&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146904789 444858424 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015538 CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1C(N)=O InChI=1S/C18H19Cl2N7O/c1-18(22)5-7-27(8-6-18)17-14(15(21)28)23-13-12(25-26-16(13)24-17)9-3-2-4-10(19)11(9)20/h2-4H,5-8,22H2,1H3,(H2,21,28)(H,24,25,26) XSILOAOUSQLZBJ-UHFFFAOYSA-N 488477 US10954243, Example 8 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 90.0 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488477&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 149277705 444858425 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015539 CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1C=O InChI=1S/C18H18Cl2N6O/c1-18(21)5-7-26(8-6-18)17-12(9-27)22-15-14(24-25-16(15)23-17)10-3-2-4-11(19)13(10)20/h2-4,9H,5-8,21H2,1H3,(H,23,24,25) XBAFDNBZXMKIPD-UHFFFAOYSA-N 488478 US10954243, Example 9 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 190 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488478&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 149181336 444858426 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015540 CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1Cl InChI=1S/C17H17Cl3N6/c1-17(21)5-7-26(8-6-17)16-14(20)22-13-12(24-25-15(13)23-16)9-3-2-4-10(18)11(9)19/h2-4H,5-8,21H2,1H3,(H,23,24,25) GMMYNGZNVPRARM-UHFFFAOYSA-N 488479 1-(5-chloro-3- (2,3- dichlorophenyl)- 1H-pyrazolo[3,4- b]pyrazin-6-yl)-4- methylpiperidin- 4-amine::US10954243, Example 10 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 277 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488479&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 147667084 444858427 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015541 CNc1nccc(-c2n[nH]c3nc(N4CCC(C)(N)CC4)c(CO)nc23)c1Cl InChI=1S/C18H23ClN8O/c1-18(20)4-7-27(8-5-18)17-11(9-28)23-14-13(25-26-16(14)24-17)10-3-6-22-15(21-2)12(10)19/h3,6,28H,4-5,7-9,20H2,1-2H3,(H,21,22)(H,24,25,26) JALLTYFKGRCIJA-UHFFFAOYSA-N 488480 US10954243, Example 11 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 17.0 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488480&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 148019673 444858428 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015542 CC(O)c1nc2c(n[nH]c2nc1N1CCC(C)(N)CC1)-c1cccc(Cl)c1Cl 488481 US10954243, Example 12 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 372 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488481&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 147946132 444858429 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015543 CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1C(=O)NO InChI=1S/C18H19Cl2N7O2/c1-18(21)5-7-27(8-6-18)16-14(17(28)26-29)22-13-12(24-25-15(13)23-16)9-3-2-4-10(19)11(9)20/h2-4,29H,5-8,21H2,1H3,(H,26,28)(H,23,24,25) YLUPKODEUAOTIV-UHFFFAOYSA-N 488482 US10954243, Example 13 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 224 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488482&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 149381861 444858430 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015544 CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1C(F)F InChI=1S/C18H18Cl2F2N6/c1-18(23)5-7-28(8-6-18)17-14(15(21)22)24-13-12(26-27-16(13)25-17)9-3-2-4-10(19)11(9)20/h2-4,15H,5-8,23H2,1H3,(H,25,26,27) XLKSKLXGCKYDQB-UHFFFAOYSA-N 488483 US10954243, Example 14 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 22.0 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488483&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 149237022 444858431 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015545 CC1(N)CCN(CC1)c1nc2[nH]nc(-c3cccc(Cl)c3Cl)c2nc1CF InChI=1S/C18H19Cl2FN6/c1-18(22)5-7-27(8-6-18)17-12(9-21)23-15-14(25-26-16(15)24-17)10-3-2-4-11(19)13(10)20/h2-4H,5-9,22H2,1H3,(H,24,25,26) WLVVUJTXKNHBMM-UHFFFAOYSA-N 488484 US10954243, Example 15 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1.000 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488484&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 153211342 444858432 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015546 C[C@@H]1OCC2(CCN(CC2)c2nc3[nH]nc(-c4cccc(Cl)c4Cl)c3nc2CO)[C@@H]1N 488485 US10954243, Example 16 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 4.00 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488485&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 152310635 444858433 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015547 CCNc1nccc(-c2n[nH]c3nc(N4CCC5(CO[C@@H](C)[C@H]5N)CC4)c(CO)nc23)c1Cl 488486 US10954243, Example 17 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 6.00 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488486&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 150011491 444858434 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015548 CCNc1nccc(-c2n[nH]c3nc(N4CCC5(CO[C@@H](C)[C@H]5N)CC4)c(C)nc23)c1Cl 488487 US10954243, Example 18 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 9.00 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488487&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 150250597 444858435 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015549 CCNc1nccc(-c2n[nH]c3nc(N4CCC5(CO[C@@H](C)[C@H]5N)CC4)c(Cl)nc23)c1Cl 488488 US10954243, Example 19 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 6.00 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488488&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 147823220 444858436 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015550 CNc1nccc(-c2n[nH]c3nc(N4CCC5(CO[C@@H](C)[C@H]5N)CC4)c(CO)nc23)c1Cl 488489 US10954243, Example 20 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 3.00 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488489&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 150243773 444858437 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015551 C[C@@H]1OCC2(CCN(CC2)c2nc3[nH]nc(-c4cccc(OC5COC5)c4Cl)c3nc2CO)[C@@H]1N 488490 (6-((3S,4S)-4- amino-3-methyl- 2-oxa-8- azaspiro[4.5]decan- 8-yl)-3-(2- chloro-3-(oxetan- 3-yloxy)phenyl)- 1H-pyrazolo[3,4- b]pyrazin-5- yl)methanol::US10954243, Example 21 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 558 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488490&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 151309661 444858438 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1015552 C[C@@H]1OCC2(CCN(CC2)c2nc3[nH]nc(-c4ccnc(OC5COC5)c4Cl)c3nc2CO)[C@@H]1N 488491 (6-((3S,4S)-4- amino-3-methyl-2- oxa-8- azaspiro[4.5]decan- 8-yl)-3-(3-chloro-2- (oxetan-3- yloxy)pyridin-4-yl)- 1H-pyrazolo[3,4- b]pyrazin-5- yl)methanol::US10954243, Example 22 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 48.0 US Patent 10.7270/Q2S185KT aid1805393 US10954243 Jones, P; Cross, J; Burke, J; Mcafoos, T; Kang, Z NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=488491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=488491&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 152209283 444858439 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088294 Cc1nc(cc(=O)n1-c1cccc(Cl)c1Cl)N1CCC(C)(N)CC1 InChI=1S/C17H20Cl2N4O/c1-11-21-14(22-8-6-17(2,20)7-9-22)10-15(24)23(11)13-5-3-4-12(18)16(13)19/h3-5,10H,6-9,20H2,1-2H3 HGAOJDKDTHZJNB-UHFFFAOYSA-N 497001 US11001561, Compound 2::US11104675, Example 1::US11702392, Compound 2a Tyrosine-protein phosphatase non-receptor type 11 [E76K] 510 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=497001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=497001&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146345864 459070000 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088295 C[C@@H]1OC2(C[C@@H]1N)CCN(CC2)c1cc(=O)n(c(C)n1)-c1cccc(Cl)c1Cl InChI=1S/C20H24Cl2N4O2/c1-12-15(23)11-20(28-12)6-8-25(9-7-20)17-10-18(27)26(13(2)24-17)16-5-3-4-14(21)19(16)22/h3-5,10,12,15H,6-9,11,23H2,1-2H3/t12-,15-/m0/s1 JWPCOLYANHOZLQ-WFASDCNBSA-N 516906 US11104675, Example 2a::US11104675, Example 2b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 7047 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516906&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 162678247 461602970 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088296 C[C@@H]1OC2(C[C@@H]1N)CCN(CC2)c1cc(=O)n(c(C)n1)-c1cccc(Cl)c1Cl InChI=1S/C20H24Cl2N4O2/c1-12-15(23)11-20(28-12)6-8-25(9-7-20)17-10-18(27)26(13(2)24-17)16-5-3-4-14(21)19(16)22/h3-5,10,12,15H,6-9,11,23H2,1-2H3/t12-,15-/m0/s1 JWPCOLYANHOZLQ-WFASDCNBSA-N 516906 US11104675, Example 2a::US11104675, Example 2b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 122 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516906&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 162678247 461602970 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088297 Cc1nc(cc(=O)n1-c1cccc(Cl)c1Cl)N1CCC(C)(CN)CC1 InChI=1S/C18H22Cl2N4O/c1-12-22-15(23-8-6-18(2,11-21)7-9-23)10-16(25)24(12)14-5-3-4-13(19)17(14)20/h3-5,10H,6-9,11,21H2,1-2H3 XVYAPWLPPUVJIR-UHFFFAOYSA-N 497007 US11001561, Compound 4::US11104675, Example 3::US11702392, Compound 4 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 310 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=497007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=497007&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146345874 459070005 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088298 CCC1(N)CCN(CC1)c1cc(=O)n(c(C)n1)-c1cccc(Cl)c1Cl InChI=1S/C18H22Cl2N4O/c1-3-18(21)7-9-23(10-8-18)15-11-16(25)24(12(2)22-15)14-6-4-5-13(19)17(14)20/h4-6,11H,3,7-10,21H2,1-2H3 CAGNEBQFSQCTGL-UHFFFAOYSA-N 516911 US11104675, Example 4 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 480 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516911&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146345879 461602973 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088299 C[C@@H]1OCC2(CCN(CC2)c2cc(=O)n(c(C)n2)-c2cccc(F)c2F)[C@@H]1N InChI=1S/C20H24F2N4O2/c1-12-19(23)20(11-28-12)6-8-25(9-7-20)16-10-17(27)26(13(2)24-16)15-5-3-4-14(21)18(15)22/h3-5,10,12,19H,6-9,11,23H2,1-2H3/t12-,19+/m0/s1 JCUVZMRDYXOZEC-HXPMCKFVSA-N 516912 US11104675, Example 5 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1172 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516912&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364621 461602974 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088300 C[C@@H]1OCC2(CCN(CC2)c2cc(=O)n(c(C)n2)-c2ccc(Br)c(Cl)c2Cl)[C@@H]1N InChI=1S/C20H23BrCl2N4O2/c1-11-19(24)20(10-29-11)5-7-26(8-6-20)15-9-16(28)27(12(2)25-15)14-4-3-13(21)17(22)18(14)23/h3-4,9,11,19H,5-8,10,24H2,1-2H3/t11-,19+/m0/s1 CWJRRLNTFSKUIR-JEOXALJRSA-N 516913 US11104675, Example 6 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 203 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516913&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364661 461602975 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088301 COc1cccc(c1Cl)-n1c(C)nc(cc1=O)N1CCC2(CO[C@@H](C)[C@H]2N)CC1 InChI=1S/C21H27ClN4O3/c1-13-20(23)21(12-29-13)7-9-25(10-8-21)17-11-18(27)26(14(2)24-17)15-5-4-6-16(28-3)19(15)22/h4-6,11,13,20H,7-10,12,23H2,1-3H3/t13-,20+/m0/s1 XGKAPXAPQHXZHR-RNODOKPDSA-N 516914 US11104675, Example 7a Tyrosine-protein phosphatase non-receptor type 11 [E76K] >10000 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516914&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364375 461602976 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088302 COc1cccc(c1Cl)-n1c(C)nc(cc1=O)N1CCC2(CO[C@@H](C)[C@H]2N)CC1 InChI=1S/C21H27ClN4O3/c1-13-20(23)21(12-29-13)7-9-25(10-8-21)17-11-18(27)26(14(2)24-17)15-5-4-6-16(28-3)19(15)22/h4-6,11,13,20H,7-10,12,23H2,1-3H3/t13-,20+/m0/s1 XGKAPXAPQHXZHR-RNODOKPDSA-N 516915 US11104675, Example 7b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 153 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516915&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364375 461602977 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088303 C[C@@H]1OCC2(CCN(CC2)c2cc(=O)n(c(C)n2)-c2cccc(Cl)c2Br)[C@@H]1N InChI=1S/C20H24BrClN4O2/c1-12-19(23)20(11-28-12)6-8-25(9-7-20)16-10-17(27)26(13(2)24-16)15-5-3-4-14(22)18(15)21/h3-5,10,12,19H,6-9,11,23H2,1-2H3/t12-,19+/m0/s1 WRUDLRDXCKKXPW-HXPMCKFVSA-N 516916 US11104675, Example 8 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 360 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516916&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364376 461602978 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088304 C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3cccc(Cl)c3Cl)c(=O)c2Cl)[C@@H]1N InChI=1S/C20H23Cl3N4O2/c1-11-17(24)20(10-29-11)6-8-26(9-7-20)18-16(23)19(28)27(12(2)25-18)14-5-3-4-13(21)15(14)22/h3-5,11,17H,6-10,24H2,1-2H3/t11-,17+/m0/s1 IHKHKMXWPFOHFR-APPDUMDISA-N 516917 US11104675, Example 9 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 45.0 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516917&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364426 461602979 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088305 C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3cccc(Cl)c3Cl)c(=O)c2C)[C@@H]1N InChI=1S/C21H26Cl2N4O2/c1-12-19(26-9-7-21(8-10-26)11-29-13(2)18(21)24)25-14(3)27(20(12)28)16-6-4-5-15(22)17(16)23/h4-6,13,18H,7-11,24H2,1-3H3/t13-,18+/m0/s1 ABKATOFAZUIEJX-SCLBCKFNSA-N 497074 US11001561, Compound 63::US11001561, Compound 63a::US11104675, Example 10b::US11702392, Compound 63 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 2583 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=497074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=497074&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364430 459070069 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088306 C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3cccc(Cl)c3Cl)c(=O)c2C)[C@@H]1N InChI=1S/C21H26Cl2N4O2/c1-12-19(26-9-7-21(8-10-26)11-29-13(2)18(21)24)25-14(3)27(20(12)28)16-6-4-5-15(22)17(16)23/h4-6,13,18H,7-11,24H2,1-3H3/t13-,18+/m0/s1 ABKATOFAZUIEJX-SCLBCKFNSA-N 497074 US11001561, Compound 63::US11001561, Compound 63a::US11104675, Example 10b::US11702392, Compound 63 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 28.0 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=497074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=497074&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364430 459070069 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088307 C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3cccc(Cl)c3Cl)c(=O)c2C(F)(F)F)[C@@H]1N InChI=1S/C21H23Cl2F3N4O2/c1-11-17(27)20(10-32-11)6-8-29(9-7-20)18-15(21(24,25)26)19(31)30(12(2)28-18)14-5-3-4-13(22)16(14)23/h3-5,11,17H,6-10,27H2,1-2H3/t11-,17+/m0/s1 LCXRXVJQHMVRDX-APPDUMDISA-N 497029 US11001561, Compound 24::US11104675, Example 11::US11702392, Compound 24 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 366 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=497029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=497029&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364664 459070026 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088308 C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3cccc(Cl)c3Cl)c(=O)c2Br)[C@@H]1N InChI=1S/C20H23BrCl2N4O2/c1-11-17(24)20(10-29-11)6-8-26(9-7-20)18-15(21)19(28)27(12(2)25-18)14-5-3-4-13(22)16(14)23/h3-5,11,17H,6-10,24H2,1-2H3/t11-,17+/m0/s1 SWICSQAPZMESJY-APPDUMDISA-N 516921 US11104675, Example 12a::US11104675, Example 12b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 3457 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516921&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364611 461602983 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088309 C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3cccc(Cl)c3Cl)c(=O)c2Br)[C@@H]1N InChI=1S/C20H23BrCl2N4O2/c1-11-17(24)20(10-29-11)6-8-26(9-7-20)18-15(21)19(28)27(12(2)25-18)14-5-3-4-13(22)16(14)23/h3-5,11,17H,6-10,24H2,1-2H3/t11-,17+/m0/s1 SWICSQAPZMESJY-APPDUMDISA-N 516921 US11104675, Example 12a::US11104675, Example 12b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 20.0 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516921&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364611 461602983 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088310 C[C@@H]1OCC2(CCN(CC2)c2cc(=O)n(c(C)n2)-c2cccc(C)c2Cl)[C@@H]1N InChI=1S/C21H27ClN4O2/c1-13-5-4-6-16(19(13)22)26-15(3)24-17(11-18(26)27)25-9-7-21(8-10-25)12-28-14(2)20(21)23/h4-6,11,14,20H,7-10,12,23H2,1-3H3/t14-,20+/m0/s1 FUQGOVIEBZOVIW-VBKZILBWSA-N 516923 US11104675, Example 13a::US11104675, Example 13b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 7500 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516923&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364666 461602984 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088311 C[C@@H]1OCC2(CCN(CC2)c2cc(=O)n(c(C)n2)-c2cccc(C)c2Cl)[C@@H]1N InChI=1S/C21H27ClN4O2/c1-13-5-4-6-16(19(13)22)26-15(3)24-17(11-18(26)27)25-9-7-21(8-10-25)12-28-14(2)20(21)23/h4-6,11,14,20H,7-10,12,23H2,1-3H3/t14-,20+/m0/s1 FUQGOVIEBZOVIW-VBKZILBWSA-N 516923 US11104675, Example 13a::US11104675, Example 13b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 186 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516923&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364666 461602984 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088312 C[C@@H]1OCC2(CCN(CC2)c2cc(=O)n(c(C)n2)-c2cccc(c2Cl)C(F)(F)F)[C@@H]1N InChI=1S/C21H24ClF3N4O2/c1-12-19(26)20(11-31-12)6-8-28(9-7-20)16-10-17(30)29(13(2)27-16)15-5-3-4-14(18(15)22)21(23,24)25/h3-5,10,12,19H,6-9,11,26H2,1-2H3/t12-,19+/m0/s1 AUTPODHEFRQTEM-HXPMCKFVSA-N 516925 US11104675, Example 14a::US11104675, Example 14b Tyrosine-protein phosphatase non-receptor type 11 [E76K] >1000 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516925&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364379 461602985 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088313 C[C@@H]1OCC2(CCN(CC2)c2cc(=O)n(c(C)n2)-c2cccc(c2Cl)C(F)(F)F)[C@@H]1N InChI=1S/C21H24ClF3N4O2/c1-12-19(26)20(11-31-12)6-8-28(9-7-20)16-10-17(30)29(13(2)27-16)15-5-3-4-14(18(15)22)21(23,24)25/h3-5,10,12,19H,6-9,11,26H2,1-2H3/t12-,19+/m0/s1 AUTPODHEFRQTEM-HXPMCKFVSA-N 516925 US11104675, Example 14a::US11104675, Example 14b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 703 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516925&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364379 461602985 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088314 C[C@@H]1OCC2(CCN(CC2)c2cc(=O)n(c(C)n2)-c2ccc(Oc3ccccc3)cc2)[C@@H]1N InChI=1S/C26H30N4O3/c1-18-25(27)26(17-32-18)12-14-29(15-13-26)23-16-24(31)30(19(2)28-23)20-8-10-22(11-9-20)33-21-6-4-3-5-7-21/h3-11,16,18,25H,12-15,17,27H2,1-2H3/t18-,25+/m0/s1 YIHCMHNKEYIOKH-AVRWGWEMSA-N 516927 US11104675, Example 15a::US11104675, Example 15b Tyrosine-protein phosphatase non-receptor type 11 [E76K] >1000 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516927&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 162678249 461602986 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088315 C[C@@H]1OCC2(CCN(CC2)c2cc(=O)n(c(C)n2)-c2ccc(Oc3ccccc3)cc2)[C@@H]1N InChI=1S/C26H30N4O3/c1-18-25(27)26(17-32-18)12-14-29(15-13-26)23-16-24(31)30(19(2)28-23)20-8-10-22(11-9-20)33-21-6-4-3-5-7-21/h3-11,16,18,25H,12-15,17,27H2,1-2H3/t18-,25+/m0/s1 YIHCMHNKEYIOKH-AVRWGWEMSA-N 516927 US11104675, Example 15a::US11104675, Example 15b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 148 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516927&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 162678249 461602986 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088316 C[C@@H]1OCC2(CCN(CC2)c2cc(=O)n(c(C)n2)-c2ccc(Oc3ccn(C)n3)c(Cl)c2Cl)[C@@H]1N InChI=1S/C24H28Cl2N6O3/c1-14-23(27)24(13-34-14)7-10-31(11-8-24)18-12-20(33)32(15(2)28-18)16-4-5-17(22(26)21(16)25)35-19-6-9-30(3)29-19/h4-6,9,12,14,23H,7-8,10-11,13,27H2,1-3H3/t14-,23+/m0/s1 JHBFIMHGKSCWEA-LFVRLGFBSA-N 516929 US11104675, Example 16a::US11104675, Example 16b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 9552 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516929&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364423 461602987 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088317 C[C@@H]1OCC2(CCN(CC2)c2cc(=O)n(c(C)n2)-c2ccc(Oc3ccn(C)n3)c(Cl)c2Cl)[C@@H]1N InChI=1S/C24H28Cl2N6O3/c1-14-23(27)24(13-34-14)7-10-31(11-8-24)18-12-20(33)32(15(2)28-18)16-4-5-17(22(26)21(16)25)35-19-6-9-30(3)29-19/h4-6,9,12,14,23H,7-8,10-11,13,27H2,1-3H3/t14-,23+/m0/s1 JHBFIMHGKSCWEA-LFVRLGFBSA-N 516929 US11104675, Example 16a::US11104675, Example 16b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 92.0 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516929&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364423 461602987 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088318 C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3ccn(C)c(Cl)c3Cl)c(=O)c2Cl)[C@@H]1N 516931 US11104675, Example 17 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 618 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516931&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 162678250 461602988 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088319 C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3ccc(Cc4ccn(C)n4)c(Cl)c3Cl)c(=O)c2C)[C@@H]1N InChI=1S/C26H32Cl2N6O2/c1-15-24(33-11-8-26(9-12-33)14-36-16(2)23(26)29)30-17(3)34(25(15)35)20-6-5-18(21(27)22(20)28)13-19-7-10-32(4)31-19/h5-7,10,16,23H,8-9,11-14,29H2,1-4H3/t16-,23+/m0/s1 SNKPNPVGTKWNMV-QMHKHESXSA-N 516932 US11104675, Example 18a::US11104675, Example 18b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 511 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516932&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 162678251 461602989 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088320 C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3ccc(Cc4ccn(C)n4)c(Cl)c3Cl)c(=O)c2C)[C@@H]1N InChI=1S/C26H32Cl2N6O2/c1-15-24(33-11-8-26(9-12-33)14-36-16(2)23(26)29)30-17(3)34(25(15)35)20-6-5-18(21(27)22(20)28)13-19-7-10-32(4)31-19/h5-7,10,16,23H,8-9,11-14,29H2,1-4H3/t16-,23+/m0/s1 SNKPNPVGTKWNMV-QMHKHESXSA-N 516932 US11104675, Example 18a::US11104675, Example 18b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 3.00 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516932&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 162678251 461602989 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088321 CNC(=O)c1ccc(Oc2ccc(c(Cl)c2Cl)-n2c(C)nc(N3CCC4(CO[C@@H](C)[C@H]4N)CC3)c(C)c2=O)cc1 InChI=1S/C29H33Cl2N5O4/c1-16-26(35-13-11-29(12-14-35)15-39-17(2)25(29)32)34-18(3)36(28(16)38)21-9-10-22(24(31)23(21)30)40-20-7-5-19(6-8-20)27(37)33-4/h5-10,17,25H,11-15,32H2,1-4H3,(H,33,37)/t17-,25+/m0/s1 QGNASPHDTCYUDR-SSOJOUAXSA-N 516934 US11104675, Example 19b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 12.0 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516934&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364373 461602990 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1088322 C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3ccc(Oc4cc[nH]n4)c(Cl)c3Cl)c(=O)c2C)[C@@H]1N 516935 US11104675, Example 20b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 5.00 US Patent 10.7270/Q2GQ71XC aid1805891 US11104675 Jones, P; Czako, B; Carroll, CL; Mandal, P; Cross, J NAVIRE PHARMA, INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516935&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 146364374 461602991 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214039 N[C@@H]1CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 576110 7-[3-(2-amino-3- chloropyridine-4-yl)- 1H-pyrazolo[3,4-b]- pyrazin-6-yl]-7-aza- spiro[3.5]nonan-1- amine, enantiomer 1::US11466017, Example 136a Tyrosine-protein phosphatase non-receptor type 11 [E76K] 15155 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576110&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 166177932 474498321 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214040 N[C@H]1CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 576111 7-[3-(2-amino-3- chloropyridin-4-yl)- 1H-pyrazolo[3,4-b]- pyrazin-6-yl]-7-aza- spiro[3.5]nonan-1- amine, enantiomer 2::US11466017, Example 136b Tyrosine-protein phosphatase non-receptor type 11 [E76K] 4318 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576111&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 166177933 474498322 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214041 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(N)ncc1Cl 384215 (4S)-8-[3-(2-amino- 5-chloropyridin-4- yl)-1H-pyrazolo[3,4- b]pyrazin-6-yl]-2- oxa-8-azaspiro[4.5]- decan-4-amine::US10280171, Example 137::US10851110, Example 137::US11466017, Example 137 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 504 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384215&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167159 404853499 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214042 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(N)ccc1Cl InChI=1S/C17H20ClN7/c1-17(20)4-6-25(7-5-17)13-9-21-15-14(23-24-16(15)22-13)11-8-10(19)2-3-12(11)18/h2-3,8-9H,4-7,19-20H2,1H3,(H,22,23,24) ABECVSURQGZTBR-UHFFFAOYSA-N 384216 4-[6-(4-amino-4- methylpiperidin-1- yl)-1H-pyrazolo[3,4- b]pyrazin-3-yl]-5- chloropyridin-2- amine::US10280171, Example 138::US10851110, Example 138::US11466017, Example 138 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 587 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384216&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132180687 404853500 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213948 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C17H18Cl2N6/c1-17(20)5-7-25(8-6-17)12-9-21-15-14(23-24-16(15)22-12)10-3-2-4-11(18)13(10)19/h2-4,9H,5-8,20H2,1H3,(H,22,23,24) AMADCPJVPLUGQO-UHFFFAOYSA-N 384117 1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-amine::US10280171, Example 1::US10851110, Example 1::US11466017, Example 1::US11529347, Compound 23 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 110 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384117&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search U9Y 6WU8 132166923 404853403 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213949 Clc1cccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCNC3)CC2)c1Cl InChI=1S/C19H20Cl2N6/c20-13-3-1-2-12(15(13)21)16-17-18(26-25-16)24-14(10-23-17)27-8-5-19(6-9-27)4-7-22-11-19/h1-3,10,22H,4-9,11H2,(H,24,25,26) ISZYHBGNJBUGLA-UHFFFAOYSA-N 384118 8-(3-(2,3-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-2,8- diazaspiro- [4.5]decane::US10280171, Example 2::US10851110, Example 2::US11466017, Example 2 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 787 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384118&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166744 404853404 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213950 N[C@H]1[C@@H]2CN(C[C@H]12)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 384119 (1R,5S,6S)-3-(3-(2,3- dichlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-3-aza- bicyclo[3.1.0]hexan- 6-amine::US10280171, Example 3::US10851110, Example 3::US11466017, Example 3 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1072 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384119&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166986 404853405 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213951 CNC1(C)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C18H20Cl2N6/c1-18(21-2)6-8-26(9-7-18)13-10-22-16-15(24-25-17(16)23-13)11-4-3-5-12(19)14(11)20/h3-5,10,21H,6-9H2,1-2H3,(H,23,24,25) MEDFNRZYVCVZEM-UHFFFAOYSA-N 384120 1-(3-(2,3- Dichlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-N,4- dimethylpiperidin-4- amine::US10280171, Example 6::US10851110, Example 6::US11466017, Example 6 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 2.00 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384120&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166914 404853406 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213952 Clc1cccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCN3)CC2)c1Cl InChI=1S/C18H18Cl2N6/c19-12-3-1-2-11(14(12)20)15-16-17(25-24-15)23-13(10-21-16)26-8-5-18(6-9-26)4-7-22-18/h1-3,10,22H,4-9H2,(H,23,24,25) GBRTUCQWCTVZDK-UHFFFAOYSA-N 384121 3-(2,3-dichloro- phenyl)-6-(1,7-diaza- spiro[3.5]nonan-7- yl)-1H-pyrazolo[3,4- b]pyrazine::US10280171, Example 7::US10851110, Example 7::US11466017, Example 7 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 196 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384121&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166833 404853407 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213953 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C17H18Cl2N6O/c18-11-3-1-2-10(13(11)19)14-15-16(24-23-14)22-12(8-21-15)25-6-4-17(26,9-20)5-7-25/h1-3,8,26H,4-7,9,20H2,(H,22,23,24) CCNVAVIEHMNTEE-UHFFFAOYSA-N 384122 4-(aminomethyl)-1- (3-(2,3-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)- piperidin-4-ol::US10280171, Example 8::US10851110, Example 8::US11466017, Example 8 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 204 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384122&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166826 404853408 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213954 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C18H20Cl2N6/c1-18(10-21)5-7-26(8-6-18)13-9-22-16-15(24-25-17(16)23-13)11-3-2-4-12(19)14(11)20/h2-4,9H,5-8,10,21H2,1H3,(H,23,24,25) KZCSSNUZWXPJCN-UHFFFAOYSA-N 576022 (1-(3-(3-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- yl)methanamine::US11466017, Example 9::US11529347, Compound 10 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 367 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576022&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166860 474498233 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213955 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1 InChI=1S/C17H19ClN6/c1-17(19)5-7-24(8-6-17)13-10-20-15-14(22-23-16(15)21-13)11-3-2-4-12(18)9-11/h2-4,9-10H,5-8,19H2,1H3,(H,21,22,23) NHGRNRILMHNSIR-UHFFFAOYSA-N 384124 1-(3-(3-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 10::US10851110, Example 10::US11466017, Example 10::US11529347, Compound 31 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 333 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384124&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166907 404853410 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213956 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(Cl)cc(Cl)c1 InChI=1S/C18H20Cl2N6/c1-18(10-21)2-4-26(5-3-18)14-9-22-16-15(24-25-17(16)23-14)11-6-12(19)8-13(20)7-11/h6-9H,2-5,10,21H2,1H3,(H,23,24,25) RQJVSHGOYHHYSM-UHFFFAOYSA-N 384125 (1-(3-(3,5-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 11::US10851110, Example 11::US11466017, Example 11 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 632 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384125&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167035 404853411 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213957 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(Cl)cc(Cl)c1 InChI=1S/C17H18Cl2N6/c1-17(20)2-4-25(5-3-17)13-9-21-15-14(23-24-16(15)22-13)10-6-11(18)8-12(19)7-10/h6-9H,2-5,20H2,1H3,(H,22,23,24) ZLSAGPLZHAPKDO-UHFFFAOYSA-N 384126 1-(3-(3,5-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 12::US10851110, Example 12::US11466017, Example 12 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 404 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384126&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166892 404853412 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213958 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C18H20Cl2N6/c1-18(10-21)4-6-26(7-5-18)14-9-22-16-15(24-25-17(16)23-14)11-2-3-12(19)13(20)8-11/h2-3,8-9H,4-7,10,21H2,1H3,(H,23,24,25) LJXXZVLIMZSWLE-UHFFFAOYSA-N 384127 (1-(3-(3,4-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 13::US10851110, Example 13::US11466017, Example 13 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 158 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384127&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167147 404853413 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213959 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(F)c(Cl)c1 InChI=1S/C18H20ClFN6/c1-18(10-21)4-6-26(7-5-18)14-9-22-16-15(24-25-17(16)23-14)11-2-3-13(20)12(19)8-11/h2-3,8-9H,4-7,10,21H2,1H3,(H,23,24,25) HXKDFUSJAFLWKF-UHFFFAOYSA-N 384128 (1-(3-(3-Chloro-4- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 14::US10851110, Example 14::US11466017, Example 14 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 521 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384128&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166905 404853414 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213960 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)cc1 InChI=1S/C17H19ClN6/c1-17(19)6-8-24(9-7-17)13-10-20-15-14(22-23-16(15)21-13)11-2-4-12(18)5-3-11/h2-5,10H,6-9,19H2,1H3,(H,21,22,23) MGGGLWKKMYVXPD-UHFFFAOYSA-N 384129 1-(3-(4-Chlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-amine::US10280171, Example 15::US10851110, Example 15::US11466017, Example 15::US11529347, Compound 17 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 140 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384129&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166901 404853415 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213961 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)cc1 InChI=1S/C18H21ClN6/c1-18(11-20)6-8-25(9-7-18)14-10-21-16-15(23-24-17(16)22-14)12-2-4-13(19)5-3-12/h2-5,10H,6-9,11,20H2,1H3,(H,22,23,24) BHDQDMSKLZFAOP-UHFFFAOYSA-N 384130 (1-(3-(4-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin- methanamine::US10280171, Example 16::US10851110, Example 16::US11466017, Example 16::US11529347, Compound 29 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 169 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384130&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176105 404853416 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213962 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)c(Cl)c1 384159 (R)-8-(3-(3,4-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 46::US10851110, Example 46::US11466017, Example 46 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 118 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384159&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167057 404853445 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213963 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C17H18Cl2N6/c1-17(20)4-6-25(7-5-17)13-9-21-15-14(23-24-16(15)22-13)10-2-3-11(18)12(19)8-10/h2-3,8-9H,4-7,20H2,1H3,(H,22,23,24) IEUPVYYCTFCLTF-UHFFFAOYSA-N 384132 1-(3-(3,4-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 18::US10851110, Example 18::US11466017, Example 18 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 141 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384132&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167085 404853418 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213964 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(F)c(Cl)c1 InChI=1S/C17H18ClFN6/c1-17(20)4-6-25(7-5-17)13-9-21-15-14(23-24-16(15)22-13)10-2-3-12(19)11(18)8-10/h2-3,8-9H,4-7,20H2,1H3,(H,22,23,24) HILFUTGZGNSLCF-UHFFFAOYSA-N 384133 1-(3-(3-Chloro-4- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 19::US10851110, Example 19::US11466017, Example 19 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 510 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384133&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166896 404853419 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213965 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl InChI=1S/C17H19ClN6/c1-17(19)6-8-24(9-7-17)13-10-20-15-14(22-23-16(15)21-13)11-4-2-3-5-12(11)18/h2-5,10H,6-9,19H2,1H3,(H,21,22,23) JQWPQEJDTUKOCS-UHFFFAOYSA-N 384134 1-(3-(2- Chlorophenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 20::US10851110, Example 20::US11466017, Example 20::US11529347, Compound 6 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 326 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384134&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167115 404853420 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213966 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(c1)C(F)(F)F InChI=1S/C18H19F3N6/c1-17(22)5-7-27(8-6-17)13-10-23-15-14(25-26-16(15)24-13)11-3-2-4-12(9-11)18(19,20)21/h2-4,9-10H,5-8,22H2,1H3,(H,24,25,26) UCVNJKUCRRXAMU-UHFFFAOYSA-N 384135 4-Methyl-1-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)piperidin-4-amine::US10280171, Example 21::US10851110, Example 21::US11466017, Example 21 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 956 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384135&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166903 404853421 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213967 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(c1)C(F)(F)F InChI=1S/C19H21F3N6/c1-18(11-23)5-7-28(8-6-18)14-10-24-16-15(26-27-17(16)25-14)12-3-2-4-13(9-12)19(20,21)22/h2-4,9-10H,5-8,11,23H2,1H3,(H,25,26,27) VBWUNPVCLSZAAP-UHFFFAOYSA-N 384136 (4-methyl-1-(3-(3- (trifluoromethyl)- phenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)- piperidin-4-yl)- methanamine::US10280171, Example 22::US10851110, Example 22::US11466017, Example 22 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1747 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384136&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167094 404853422 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213968 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccnc1Cl InChI=1S/C16H18ClN7/c1-16(18)4-7-24(8-5-16)11-9-20-13-12(22-23-15(13)21-11)10-3-2-6-19-14(10)17/h2-3,6,9H,4-5,7-8,18H2,1H3,(H,21,22,23) KUMMBNPRGBFMLN-UHFFFAOYSA-N 384137 1-(3-(2-chloro- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methyl-piperidin-4- amine::US10280171, Example 23::US10851110, Example 23::US11466017, Example 23 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1824 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384137&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166863 404853423 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213969 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(F)c1Cl InChI=1S/C17H18ClFN6/c1-17(20)5-7-25(8-6-17)12-9-21-15-14(23-24-16(15)22-12)10-3-2-4-11(19)13(10)18/h2-4,9H,5-8,20H2,1H3,(H,22,23,24) QKNOZCPUZKQEHX-UHFFFAOYSA-N 384138 1-(3-(2-chloro-3- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methyl-piperidin-4- amine::US10280171, Example 24::US10851110, Example 24::US11466017, Example 24 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 204 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384138&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166810 404853424 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213970 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1F InChI=1S/C18H20ClFN6/c1-18(10-21)5-7-26(8-6-18)13-9-22-16-15(24-25-17(16)23-13)11-3-2-4-12(19)14(11)20/h2-4,9H,5-8,10,21H2,1H3,(H,23,24,25) CUTMOOSDQSRDHK-UHFFFAOYSA-N 384139 (1-(3-(3-Chloro-2-fluorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)-methanamine::US10280171, Example 25::US10851110, Example 25::US11466017, Example 25::US11529347, Compound 48 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 101 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384139&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166994 404853425 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213971 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1F InChI=1S/C17H18ClFN6/c1-17(20)5-7-25(8-6-17)12-9-21-15-14(23-24-16(15)22-12)10-3-2-4-11(18)13(10)19/h2-4,9H,5-8,20H2,1H3,(H,22,23,24) QROQTLNVCIGXBV-UHFFFAOYSA-N 384140 1-(3-(3-chloro-2- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4- amine::US10280171, Example 26::US10851110, Example 26::US11466017, Example 26::US11529347, Compound 7 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 213 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384140&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166959 404853426 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213972 COc1cccc(-c2n[nH]c3nc(cnc23)N2CCC(C)(CN)CC2)c1Cl InChI=1S/C19H23ClN6O/c1-19(11-21)6-8-26(9-7-19)14-10-22-17-16(24-25-18(17)23-14)12-4-3-5-13(27-2)15(12)20/h3-5,10H,6-9,11,21H2,1-2H3,(H,23,24,25) NQCYZSVEYSASFG-UHFFFAOYSA-N 384141 (1-(3-(2-chloro-3- methoxy phenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 27::US10851110, Example 27::US11466017, Example 27::US11529347, Compound 39 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 80.0 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384141&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166928 404853427 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213973 Cc1c(Cl)cccc1-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 InChI=1S/C19H23ClN6/c1-12-13(4-3-5-14(12)20)16-17-18(25-24-16)23-15(10-22-17)26-8-6-19(2,11-21)7-9-26/h3-5,10H,6-9,11,21H2,1-2H3,(H,23,24,25) DEVINZPHNDARNY-UHFFFAOYSA-N 384142 (1-(3-(3-chloro-2- methylphenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 28::US10851110, Example 28::US11466017, Example 28 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 142 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384142&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166891 404853428 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213974 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl InChI=1S/C18H21ClN6/c1-18(11-20)6-8-25(9-7-18)14-10-21-16-15(23-24-17(16)22-14)12-4-2-3-5-13(12)19/h2-5,10H,6-9,11,20H2,1H3,(H,22,23,24) JCYHCBVXAFUBRD-UHFFFAOYSA-N 384143 (1-(3-(2-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin- methanamine::US10280171, Example 29::US10851110, Example 29::US11466017, Example 29::US11529347, Compound 43 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 178 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384143&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176109 404853429 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213975 Cc1ncccc1-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 InChI=1S/C18H23N7/c1-12-13(4-3-7-20-12)15-16-17(24-23-15)22-14(10-21-16)25-8-5-18(2,11-19)6-9-25/h3-4,7,10H,5-6,8-9,11,19H2,1-2H3,(H,22,23,24) UJEPRQRVJYIQTG-UHFFFAOYSA-N 384144 (4-methyl-1-(3-(2- methylpyridin-3-yl)- 1H-pyrazolo[3,4- b]pyrazin-6-yl)- piperidin-4-yl) methanamine::US10280171, Example 30::US10851110, Example 30::US11466017, Example 30 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 2509 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384144&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166785 404853430 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213976 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccncc1Cl InChI=1S/C17H20ClN7/c1-17(10-19)3-6-25(7-4-17)13-9-21-15-14(23-24-16(15)22-13)11-2-5-20-8-12(11)18/h2,5,8-9H,3-4,6-7,10,19H2,1H3,(H,22,23,24) HZYUNIMXNROZHD-UHFFFAOYSA-N 384145 (1-(3-(3-chloro- pyridin-4-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 31::US10851110, Example 31::US11466017, Example 31 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 929 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384145&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167009 404853431 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213977 COc1cc(ccc1Cl)-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 InChI=1S/C19H23ClN6O/c1-19(11-21)5-7-26(8-6-19)15-10-22-17-16(24-25-18(17)23-15)12-3-4-13(20)14(9-12)27-2/h3-4,9-10H,5-8,11,21H2,1-2H3,(H,23,24,25) XEMDEEZOTNHZCZ-UHFFFAOYSA-N 384147 (1-(3-(4-Chloro-3-methoxyphenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-yl)methanamine::US10280171, Example 33::US10851110, Example 33::US11466017, Example 33 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 72.0 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384147&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166819 404853433 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213978 COc1cc(ccc1Cl)-c1n[nH]c2nc(cnc12)N1CCC2(CCC[C@H]2N)CC1 384148 (R)-8-(3-(4-chloro-3- methoxyphenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 34::US10851110, Example 34::US11466017, Example 34 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 102 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384148&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166932 404853434 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213979 COc1cc(Cl)cc(c1)-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 InChI=1S/C19H23ClN6O/c1-19(11-21)3-5-26(6-4-19)15-10-22-17-16(24-25-18(17)23-15)12-7-13(20)9-14(8-12)27-2/h7-10H,3-6,11,21H2,1-2H3,(H,23,24,25) ZXABOENZJMEVQC-UHFFFAOYSA-N 384149 (1-(3-(3-chloro-5- methoxyphenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 35::US10851110, Example 35::US11466017, Example 35 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 304 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384149&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167103 404853435 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213980 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccnc1Cl InChI=1S/C17H20ClN7/c1-17(10-19)4-7-25(8-5-17)12-9-21-14-13(23-24-16(14)22-12)11-3-2-6-20-15(11)18/h2-3,6,9H,4-5,7-8,10,19H2,1H3,(H,22,23,24) ACZCNRCVPUGLCW-UHFFFAOYSA-N 384150 (1-(3-(2-chloro- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- methylpiperidin-4-yl) methanamine::US10280171, Example 36::US10851110, Example 36::US11466017, Example 36 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 967 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384150&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166991 404853436 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213981 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(F)c1Cl InChI=1S/C17H18ClFN6O/c18-13-10(2-1-3-11(13)19)14-15-16(24-23-14)22-12(8-21-15)25-6-4-17(26,9-20)5-7-25/h1-3,8,26H,4-7,9,20H2,(H,22,23,24) YFIASUMJKJCVBV-UHFFFAOYSA-N 384151 4-(Aminomethyl)-1-(3-(2-chloro-3-fluorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-piperidin-4-ol::US10280171, Example 37::US10851110, Example 37::US11466017, Example 37 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 623 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384151&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166812 404853437 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213982 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 384152 (S)-8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2-oxa-8-azaspiro[4.5]-decan-4-amine::US10280171, Example 38::US10851110, Example 38::US11466017, Example 38 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 75.0 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384152&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166974 404853438 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213983 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl 384153 (S)-8-(3-(2-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-2-oxa- 8-azaspiro[4.5]- decan-4-amine::US10280171, Example 39::US10851110, Example 39::US11466017, Example 39 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 158 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384153&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166852 404853439 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213984 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1c(F)cccc1Cl 384154 (4S)-8-(3-(2-Chloro- 6-fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-2-oxa- 8-azaspiro[4.5]- decan-4-amine::US10280171, Example 40::US10851110, Example 40::US11466017, Example 40 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 203 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384154&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167117 404853440 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213985 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccnc1Cl 384155 (S)-8-(3-(2-chloro- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-2-oxa- 8-azaspiro[4.5]- decan-4-amine trifluoroacetate::US10280171, Example 41::US10851110, Example 41::US11466017, Example 41 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 966 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384155&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166850 404853441 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213986 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1 384157 (R)-8-(3-(3-chloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]-decan-1- amine::US10280171, Example 44::US10851110, Example 44::US11466017, Example 44 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 429 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384157&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166809 404853443 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213987 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(Cl)cc(Cl)c1 384158 (R)-8-(3-(3,5-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 45::US10851110, Example 45::US11466017, Example 45 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 355 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384158&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166912 404853444 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213988 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(Cl)c(Cl)c1 384159 (R)-8-(3-(3,4-dichloro- phenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 46::US10851110, Example 46::US11466017, Example 46 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 193 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384159&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167057 404853445 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213989 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccc(F)c(Cl)c1 384160 (R)-8-(3-(3-chloro-4- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 47::US10851110, Example 47::US11466017, Example 47 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 493 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384160&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166800 404853446 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213990 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(c1)C(F)(F)F 384161 (R)-8-(3-(3- (trifluoromethyl)- phenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 48::US10851110, Example 48::US11466017, Example 48 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1756 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384161&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167130 404853447 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213991 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1F 384162 (R)-8-(3-(3-chloro-2- fluorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 49::US10851110, Example 49::US11466017, Example 49 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 143 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384162&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166940 404853448 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213992 COc1cccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCC[C@H]3N)CC2)c1Cl 384163 (R)-8-(3-(2-chloro-3- methoxyphenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 50::US10851110, Example 50::US11466017, Example 50 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 39.0 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384163&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167017 404853449 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213993 Cc1c(Cl)cccc1-c1n[nH]c2nc(cnc12)N1CCC2(CCC[C@H]2N)CC1 384164 (R)-8-(3-(3-chloro-2- methylphenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 51::US10851110, Example 51::US11466017, Example 51 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 153 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384164&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166886 404853450 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213994 COc1cc(Cl)cc(c1)-c1n[nH]c2nc(cnc12)N1CCC2(CCC[C@H]2N)CC1 384165 (R)-8-(3-(3-chloro-5- methoxyphenyl)-1H- pyrazolo[3,4- b]pyrazin-6-yl)-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 52::US10851110, Example 52::US11466017, Example 52 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 313 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384165&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167063 404853451 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213995 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccnc1Cl 384166 (R)-8-(3-(2-chloro- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8- aza- spiro[4.5]decan-1- amine::US10280171, Example 53::US10851110, Example 56::US11466017, Example 53 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 641 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384166&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166913 404853452 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213996 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl 384167 (R)-8-(3-(2- chlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 54::US10851110, Example 54::US11466017, Example 54::US11529347, Compound 16 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 119 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384167&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167004 404853453 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213997 Cc1ncccc1-c1n[nH]c2nc(cnc12)N1CCC2(CCC[C@H]2N)CC1 384168 (R)-8-(3-(2-methyl- pyridin-3-yl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8- azaspiro[4.5]decan- I -amine::US10280171, Example 55::US10851110, Example 55::US11466017, Example 55 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1143 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384168&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176111 404853454 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213998 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccncc1Cl 384169 (R)-8-(3-(3-chloro- pyridin-4-y l)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 56::US11466017, Example 56 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 552 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384169&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166830 404853455 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1213999 NC1(CO)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C17H18Cl2N6O/c18-11-3-1-2-10(13(11)19)14-15-16(24-23-14)22-12(8-21-15)25-6-4-17(20,9-26)5-7-25/h1-3,8,26H,4-7,9,20H2,(H,22,23,24) YCRNZPYPOFXDCB-UHFFFAOYSA-N 384170 (4-Amino-1-(3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)piperidin-4-yl)-methanol::US10280171, Example 57::US10851110, Example 57::US11466017, Example 57 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 104 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384170&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166807 404853456 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214000 NC1(CF)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl InChI=1S/C17H17Cl2FN6/c18-11-3-1-2-10(13(11)19)14-15-16(25-24-14)23-12(8-22-15)26-6-4-17(21,9-20)5-7-26/h1-3,8H,4-7,9,21H2,(H,23,24,25) KCRBJSWWABFQLC-UHFFFAOYSA-N 384171 1-(3-(2,3-dichlo- rophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)-4- (fluoromethyl)- piperidin-4-amine::US10280171, Example 58::US10851110, Example 58::US11466017, Example 58 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 338 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384171&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176113 404853457 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214001 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl InChI=1S/C17H19ClN6O/c18-12-4-2-1-3-11(12)14-15-16(23-22-14)21-13(9-20-15)24-7-5-17(25,10-19)6-8-24/h1-4,9,25H,5-8,10,19H2,(H,21,22,23) YMDXJDQSJVLAPR-UHFFFAOYSA-N 384173 4-(aminomethyl)-1- (3-(2-chlorophenyl)- 1H-pyrazolo[3,4-b]- pyrazin-6-yl)- piperidin-4-ol::US10280171, Example 60::US10851110, Example 60::US11466017, Example 60::US11529347, Compound 52 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 918 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384173&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166856 404853459 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214002 OCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccccc1Cl InChI=1S/C17H18ClN5O2/c18-12-4-2-1-3-11(12)14-15-16(22-21-14)20-13(9-19-15)23-7-5-17(25,10-24)6-8-23/h1-4,9,24-25H,5-8,10H2,(H,20,21,22) KRNUXBVLSFDQKD-UHFFFAOYSA-N 576073 (4-amino-1-(3-(2- chlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl)- piperidin-4-yl)- methanol::US11466017, Example 61 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 401 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576073&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 155766778 474498284 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214003 N[C@@H]1[C@H](F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 576074 8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo [3,4-b] pyrazin-6-yl)-2-fluoro-8-azaspiro [4.5] decan-1-amine::US11466017, Example 64A Tyrosine-protein phosphatase non-receptor type 11 [E76K] 98.0 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576074&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176152 474498285 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214004 N[C@@H]1[C@@H](F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 475735 US10851110, Example 64B::US11466017, Example 64B Tyrosine-protein phosphatase non-receptor type 11 [E76K] 221 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=475735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=475735&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132176151 442075804 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214005 N[C@@H]1C(F)(F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 475736 8-(3-(2,3-Dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2,2-difluoro-8-azaspiro[4.5]decan-1-amine::US10851110, Example 65A::US11466017, Example 65A Tyrosine-protein phosphatase non-receptor type 11 [E76K] 235 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=475736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=475736&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 156023091 442075805 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214006 N[C@H]1C(F)(F)CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl 475737 US10851110, Example 65B::US11466017, Example 65B Tyrosine-protein phosphatase non-receptor type 11 [E76K] 471 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=475737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=475737&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132180718 442075806 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214007 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cn[nH]c1C(F)(F)F InChI=1S/C15H15F3N8/c1-14(19)2-4-26(5-3-14)9-7-20-11-10(23-25-13(11)22-9)8-6-21-24-12(8)15(16,17)18/h6-7H,2-5,19H2,1H3/b10-8- KZPBYVFZYXDAKG-NTMALXAHSA-N 384181 4-Methyl-1-(3-(5-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-piperidin-4-amine::US10280171, Example 101::US10851110, Example 101::US11466017, Example 101 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1894 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384181&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166754 404853466 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214008 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cn[nH]c1C(F)(F)F InChI=1S/C18H19F3N8/c19-18(20,21)15-10(8-24-27-15)13-14-16(28-26-13)25-12(9-23-14)29-6-4-17(5-7-29)3-1-2-11(17)22/h8-9,11H,1-7,22H2/b13-10-/t11-/m1/s1 JQQQFWFXYNBFCC-COVOJHCQSA-N 384182 (R)-8-(3-(5-(Trifluoromethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-1-amine::US10280171, Example 102::US10851110, Example 102::US11466017, Example 102 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 2154 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384182&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166930 404853467 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214009 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cn[nH]c1C(F)(F)F InChI=1S/C16H17F3N8/c1-15(8-20)2-4-27(5-3-15)10-7-21-12-11(24-26-14(12)23-10)9-6-22-25-13(9)16(17,18)19/h6-7H,2-5,8,20H2,1H3/b11-9- ZFBUAYQZKUQVSN-LUAWRHEFSA-N 384183 (R)-8-(3-(5-(Trifluoromethyl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-1-amine::US10280171, Example 103::US10851110, Example 103::US11466017, Example 103 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 2603 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384183&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166827 404853468 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214010 CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC(C)(CN)CC2)c1Cl InChI=1S/C18H23ClN8/c1-18(10-20)4-7-27(8-5-18)12-9-23-15-14(25-26-17(15)24-12)11-3-6-22-16(21-2)13(11)19/h3,6,9H,4-5,7-8,10,20H2,1-2H3,(H,21,22)(H,24,25,26) WCBNKFWTMBJQOT-UHFFFAOYSA-N 384184 4-(6-(4-(Aminomethyl)-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloro-N-methylpyridin-2-amine::US10280171, Example 104::US10851110, Example 104::US11466017, Example 104 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 99.0 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384184&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167058 404853469 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214011 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(N)c1Cl InChI=1S/C17H20ClN7/c1-17(20)5-7-25(8-6-17)12-9-21-15-14(23-24-16(15)22-12)10-3-2-4-11(19)13(10)18/h2-4,9H,5-8,19-20H2,1H3,(H,22,23,24) QUZYGWHMIMOARM-UHFFFAOYSA-N 384185 1-(3-(3-amino-2-chlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-methylpiperidin-4-amine::US10280171, Example 105::US10851110, Example 105::US11466017, Example 105 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 191 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384185&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166876 404853470 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214012 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl InChI=1S/C16H19ClN8/c1-16(19)3-6-25(7-4-16)10-8-21-13-12(23-24-15(13)22-10)9-2-5-20-14(18)11(9)17/h2,5,8H,3-4,6-7,19H2,1H3,(H2,18,20)(H,22,23,24) ZSNQCYQABMACIK-UHFFFAOYSA-N 384186 4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazine-3-yl)-3-chloropyridin-2-amine::US10280171, Example 106::US10851110, Example 106::US11466017, Example 106 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 253 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384186&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166751 404853471 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214013 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl InChI=1S/C17H21ClN8/c1-17(9-19)3-6-26(7-4-17)11-8-22-14-13(24-25-16(14)23-11)10-2-5-21-15(20)12(10)18/h2,5,8H,3-4,6-7,9,19H2,1H3,(H2,20,21)(H,23,24,25) POYNJTHRRZRCMC-UHFFFAOYSA-N 384187 4-(6-(4-(Aminomethyl)-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-amine::US10280171, Example 107::US10851110, Example 107::US11466017, Example 107 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 162 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384187&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167030 404853472 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214014 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl 384188 4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-amine::US10280171, Example 108::US10851110, Example 108::US11466017, Example 108 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 726 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384188&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166878 404853473 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214015 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl 384189 (S)-4-(6-(4-Amino-2-oxa-8-azaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-ol::US10280171, Example 109::US10851110, Example 109::US11466017, Example 109 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1095 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384189&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166793 404853474 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214016 NC1(CO)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl InChI=1S/C16H18ClN7O2/c17-11-9(1-4-19-15(11)26)12-13-14(23-22-12)21-10(7-20-13)24-5-2-16(18,8-25)3-6-24/h1,4,7,25H,2-3,5-6,8,18H2,(H,19,26)(H,21,22,23) GZGWPZGIPUFBJS-UHFFFAOYSA-N 384190 4-(6-(4-Amino-4-(hydroxymethyl)piperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-ol::US10280171, Example 110::US10851110, Example 110::US11466017, Example 110 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 3679 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384190&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166946 404853475 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214017 CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC3(CCC[C@H]3N)CC2)c1Cl 384191 (R)-8-(3-(3-Chloro-2-(methylamino)pyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-1-amine::US10280171, Example 111::US10851110, Example 111::US11466017, Example 111 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 43.0 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384191&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166783 404853476 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214018 CNc1nccc(-c2n[nH]c3nc(cnc23)N2CCC(C)(N)CC2)c1Cl InChI=1S/C17H21ClN8/c1-17(19)4-7-26(8-5-17)11-9-22-14-13(24-25-16(14)23-11)10-3-6-21-15(20-2)12(10)18/h3,6,9H,4-5,7-8,19H2,1-2H3,(H,20,21)(H,23,24,25) XLKDUTBYZJONNW-UHFFFAOYSA-N 384192 4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloro-N-methylpyridin-2-amine::US10280171, Example 112::US10851110, Example 112::US11466017, Example 112 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 128 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384192&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 37I 7R7D 132166808 404853477 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214019 C[C@@H](N)C1(C)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 576090 4-(6-(4-(1-Aminoethyl)-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-amine::US11466017, Example 113a Tyrosine-protein phosphatase non-receptor type 11 [E76K] 180 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576090&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 166177912 474498301 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214020 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl InChI=1S/C16H19ClN8O/c17-11-9(1-4-20-14(11)19)12-13-15(24-23-12)22-10(7-21-13)25-5-2-16(26,8-18)3-6-25/h1,4,7,26H,2-3,5-6,8,18H2,(H2,19,20)(H,22,23,24) QJPILDDCQKPWJV-UHFFFAOYSA-N 384194 1-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4-(aminomethyl)piperidin-4-ol::US10280171, Example 114::US10851110, Example 114::US11466017, Example 114 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 779 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384194&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166791 404853479 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214021 NC1CCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384195 7-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-7-azaspiro[3.5]nonan-1-amine::US10280171, Example 115::US10851110, Example 136b::US11466017, Example 115 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 701 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384195&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166895 404853480 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214022 N[C@@H]1COCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384196 (S)-8-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-2-oxa-8-azaspiro[4.5]decan-4-amine::US10280171, Example 116::US10851110, Example 116::US11466017, Example 116 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 132 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384196&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167093 404853481 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214023 CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl InChI=1S/C16H18ClN7O/c1-16(18)3-6-24(7-4-16)10-8-20-13-12(22-23-14(13)21-10)9-2-5-19-15(25)11(9)17/h2,5,8H,3-4,6-7,18H2,1H3,(H,19,25)(H,21,22,23) DVTOAVZTUJPMMJ-UHFFFAOYSA-N 384197 4-(6-(4-Amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-ol::US10280171, Example 117::US10851110, Example 117::US11466017, Example 117 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1941 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384197&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166752 404853482 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214024 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl InChI=1S/C17H20ClN7O/c1-17(9-19)3-6-25(7-4-17)11-8-21-14-13(23-24-15(14)22-11)10-2-5-20-16(26)12(10)18/h2,5,8H,3-4,6-7,9,19H2,1H3,(H,20,26)(H,22,23,24) NRGYUJKDKQWLQO-UHFFFAOYSA-N 384198 1-(3-(2-Amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-4(aminomethyl)piperidin-4-ol::US10280171, Example 118::US10851110, Example 118::US11466017, Example 118 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1128 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384198&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166938 404853483 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214025 Nc1nccc(-c2n[nH]c3nc(cnc23)N2CCC(N)(CO)CC2)c1Cl InChI=1S/C16H19ClN8O/c17-11-9(1-4-20-14(11)18)12-13-15(24-23-12)22-10(7-21-13)25-5-2-16(19,8-26)3-6-25/h1,4,7,26H,2-3,5-6,8,19H2,(H2,18,20)(H,22,23,24) QPRIEZJKJCCITA-UHFFFAOYSA-N 384199 (4-Amino-1-(3-(2-amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-piperidin-4-yl)methanol::US10280171, Example 119::US10851110, Example 119::US11466017, Example 119 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 422 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384199&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167100 404853484 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214026 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(O)c1Cl InChI=1S/C16H18ClN7O2/c17-11-9(1-4-19-15(11)25)12-13-14(23-22-12)21-10(7-20-13)24-5-2-16(26,8-18)3-6-24/h1,4,7,26H,2-3,5-6,8,18H2,(H,19,25)(H,21,22,23) GVSONOQWYKOEOK-UHFFFAOYSA-N 384200 4-(6-(4-(Aminomethyl)-4-hydroxypiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-chloropyridin-2-ol::US10280171, Example 120::US10851110, Example 120::US11466017, Example 120 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 5372 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384200&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166893 404853485 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214027 NC1(CO)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1c(F)cccc1Cl InChI=1S/C17H18ClFN6O/c18-10-2-1-3-11(19)13(10)14-15-16(24-23-14)22-12(8-21-15)25-6-4-17(20,9-26)5-7-25/h1-3,8,26H,4-7,9,20H2,(H,22,23,24) ZECYCODHSVTEAW-UHFFFAOYSA-N 384201 (4-Amino-1-(3-(2-chloro-6-fluorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-piperidin-4-yl)methanol::US10280171, Example 121::US10851110, Example 121::US11466017, Example 121 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1083 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384201&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166873 404853486 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214028 Cc1c(N)nccc1-c1n[nH]c2nc(cnc12)N1CCC2(CCC[C@H]2N)CC1 475759 3-(2,3-Dichlorophenyl)-6-(2,8-diazaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-b]pyrazine::US10851110, Example 122::US11466017, Example 122 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 205 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=475759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=475759&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167140 442075828 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214029 Cc1c(N)nccc1-c1n[nH]c2nc(cnc12)N1CCC(C)(N)CC1 InChI=1S/C17H22N8/c1-10-11(3-6-20-15(10)18)13-14-16(24-23-13)22-12(9-21-14)25-7-4-17(2,19)5-8-25/h3,6,9H,4-5,7-8,19H2,1-2H3,(H2,18,20)(H,22,23,24) DMNYIHIRUJAKGX-UHFFFAOYSA-N 384203 4-(6-(4-amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-methylpyridin-2-amine::US10280171, Example 123::US10851110, Example 123::US11466017, Example 123 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 670 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384203&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166867 404853488 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214030 Cc1c(N)nccc1-c1n[nH]c2nc(cnc12)N1CCC(C)(CN)CC1 InChI=1S/C18H24N8/c1-11-12(3-6-21-16(11)20)14-15-17(25-24-14)23-13(9-22-15)26-7-4-18(2,10-19)5-8-26/h3,6,9H,4-5,7-8,10,19H2,1-2H3,(H2,20,21)(H,23,24,25) LLWQCPSJCBXVHN-UHFFFAOYSA-N 384204 4-(6-(4-(Aminomethyl)-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl)-3-methylpyridin-2-amine::US10280171, Example 124::US10851110, Example 124::US11466017, Example 124 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 377 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384204&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167121 404853489 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214031 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(N)ncc1Cl 384205 (R)-8-(3-(2-amino-5-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-1-amine::US10280171, Example 125::US10851110, Example 125::US11466017, Example 125 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 509 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384205&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166759 404853490 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214032 N[C@@H]1C[C@@H](O)CC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384206 (2S,4R)-4-Amino-8-(3-(2-amino-3-chloropyridin-4-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-8-azaspiro[4.5]decan-2-ol::US10280171, Example 126::US10851110, Example 126::US11466017, Example 126 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 75.0 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384206&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166963 404853491 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214033 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl 384207 (1R)-8-[3-(2-amino- 3-chloropyridin-4- yl)-1H-pyrazolo[3,4- b]pyrazin-6-yl]-8- azaspiro[4.5]decan- 1-amine::US10280171, Example 130::US10851110, Example 130::US11466017, Example 130 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 83.0 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384207&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167042 404853492 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214034 N[C@@H]1CCCC11CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(N)c1Cl 384208 (1R)-8-[3-(3-amino- 2-chlorophenyl)-1H- pyrazolo[3,4-b]- pyrazin-6-yl]-8-aza- spiro[4.5]decan-1- amine::US10280171, Example 131::US10851110, Example 131::US11466017, Example 131 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 84.0 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384208&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166821 404853493 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214035 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(N)c1Cl InChI=1S/C18H22ClN7/c1-18(10-20)5-7-26(8-6-18)13-9-22-16-15(24-25-17(16)23-13)11-3-2-4-12(21)14(11)19/h2-4,9H,5-8,10,20-21H2,1H3,(H,23,24,25) CKEXLFZOLNCINM-UHFFFAOYSA-N 384209 3-{6-[4-(amino- methyl)-4-methyl- piperidin-1-yl]-1H- pyrazolo[3,4-b]- pyrazin-3-yl}-2- chloroaniline::US10280171, Example 132::US10851110, Example 132::US11466017, Example 132 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 119 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384209&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132167049 404853494 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214036 CC1(CN)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(N)ncc1Cl InChI=1S/C17H21ClN8/c1-17(9-19)2-4-26(5-3-17)13-8-22-15-14(24-25-16(15)23-13)10-6-12(20)21-7-11(10)18/h6-8H,2-5,9,19H2,1H3,(H2,20,21)(H,23,24,25) PIIJGIPNQPGCJA-UHFFFAOYSA-N 384210 4-{6-[4-(amino- methyl)-4-methyl- piperidin-1-yl]-1H- pyrazolo[3,4-b]- pyrazin-3-yl}-5- chloropyridin-2- amine::US10280171, Example 133::US10851110, Example 133::US11466017, Example 133 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 840 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384210&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166906 404853495 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214037 NCC1(O)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cc(N)ncc1Cl InChI=1S/C16H19ClN8O/c17-10-6-20-11(19)5-9(10)13-14-15(24-23-13)22-12(7-21-14)25-3-1-16(26,8-18)2-4-25/h5-7,26H,1-4,8,18H2,(H2,19,20)(H,22,23,24) ZNZVUWRUFRWPCO-UHFFFAOYSA-N 384211 1-[3-(2-amino-5- chloropyridin-4-yl)- 1H-pyrazolo[3,4-b]- pyrazin-6-yl]-4- (aminomethyl)- piperidin-4-ol::US10280171, Example 134::US10851110, Example 134::US11466017, Example 134 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 1532 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384211&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166958 404853496 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7 1214038 CCC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1ccnc(N)c1Cl InChI=1S/C17H21ClN8/c1-2-17(20)4-7-26(8-5-17)11-9-22-14-13(24-25-16(14)23-11)10-3-6-21-15(19)12(10)18/h3,6,9H,2,4-5,7-8,20H2,1H3,(H2,19,21)(H,23,24,25) LVBIHNDCEXHSGZ-UHFFFAOYSA-N 384212 4-[6-(4-amino-4- ethylpiperidin-1-yl)- 1H-pyrazolo[3,4-b]- pyrazin-3-yl]-3- chloropyridin-2- amine::US10280171, Example 135::US10851110, Example 135::US11466017, Example 135 Tyrosine-protein phosphatase non-receptor type 11 [E76K] 529 US Patent 10.7270/Q2TB1B4T aid1806882 US11466017 Jones, P; Czako, B; Cross, J; Leonard, P; Mseeh, F; Parker, C BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=384212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=645&target=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=384212&enzyme=Tyrosine-protein+phosphatase+non-receptor+type+11+%5BE76K%5D&column=ki&startPg=0&Increment=50&submit=Search 132166848 404853497 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAKLVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 4JEG,6CMQ,6CMS,6CRF,6CRG,6R5G Tyrosine-protein phosphatase non-receptor type 11 PTN11_HUMAN Q06124 A8K1D9 Q96HD7