BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50781437 Nc1nc2n(c[n+](Cc3ccccc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O InChI=1S/C17H20N5O8P/c18-17-19-14-11(15(25)20-17)21(6-9-4-2-1-3-5-9)8-22(14)16-13(24)12(23)10(30-16)7-29-31(26,27)28/h1-5,8,10,12-13,16,23-24H,6-7H2,(H4-,18,19,20,25,26,27,28)/p+1/t10-,12-,13-,16-/m1/s1 WMKJRKYLDWLLPS-XNIJJKJLSA-O 50249977 CHEMBL1234304 Eukaryotic translation initiation factor 4E 800 ChEMBL 10.1021/acs.jmedchem.7b00916 10.7270/Q28W3GRV 28858511 Okon, A; Han, J; Dawadi, S; Demosthenous, C; Aldrich, CC; Gupta, M; Wagner, CR Mayo Clinic http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50249977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50249977&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search GQ 2V8X 135566346 401961833 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 217586 NC(=O)c1ccc(Cl)c(c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H13Cl3N2O3S/c24-17-5-3-12(21(27)29)7-15(17)14-4-1-13(8-16(14)23(30)31)22-28-20(10-32-22)11-2-6-18(25)19(26)9-11/h1-10H,(H2,27,29)(H,30,31) BSVWOYDDVWFPJD-UHFFFAOYSA-N 60451 US9073881, 109 Eukaryotic translation initiation factor 4E 3700 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60451&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536085 313084634 ZINC03338687 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310903 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(F)cc1 InChI=1S/C22H13FN2O4S/c23-15-8-5-13(6-9-15)19-12-30-21(24-19)14-7-10-16(18(11-14)22(26)27)17-3-1-2-4-20(17)25(28)29/h1-12H,(H,26,27) TYUMSTKHKAJFIM-UHFFFAOYSA-N 167252 US9073881, 1 Eukaryotic translation initiation factor 4E 19000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167252&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535813 312321108 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310904 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(OC(F)(F)F)cc1 InChI=1S/C23H13F3N2O5S/c24-23(25,26)33-15-8-5-13(6-9-15)19-12-34-21(27-19)14-7-10-16(18(11-14)22(29)30)17-3-1-2-4-20(17)28(31)32/h1-12H,(H,29,30) SJXIIKDIJYIYEJ-UHFFFAOYSA-N 167253 US9073881, 2 Eukaryotic translation initiation factor 4E 2600 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167253&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535812 312321109 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310905 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(OC(F)F)cc1 InChI=1S/C23H14F2N2O5S/c24-23(25)32-15-8-5-13(6-9-15)19-12-33-21(26-19)14-7-10-16(18(11-14)22(28)29)17-3-1-2-4-20(17)27(30)31/h1-12,23H,(H,28,29) ZTYVADOPDATVKQ-UHFFFAOYSA-N 167254 US9073881, 3 Eukaryotic translation initiation factor 4E 9900 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167254&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536079 312321110 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310906 OC(=O)c1cc(ccc1-c1cc(ccc1[N+]([O-])=O)C(F)(F)F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H11Cl2F3N2O4S/c24-17-5-2-11(8-18(17)25)19-10-35-21(29-19)12-1-4-14(16(7-12)22(31)32)15-9-13(23(26,27)28)3-6-20(15)30(33)34/h1-10H,(H,31,32) VTYWGNAVIMANCM-UHFFFAOYSA-N 167255 US9073881, 4 Eukaryotic translation initiation factor 4E 2000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167255&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538602 312321111 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310907 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccccc1C(F)(F)F InChI=1S/C23H13F3N2O4S/c24-23(25,26)18-7-3-1-6-16(18)19-12-33-21(27-19)13-9-10-14(17(11-13)22(29)30)15-5-2-4-8-20(15)28(31)32/h1-12H,(H,29,30) KVCDMVFZRHJNAS-UHFFFAOYSA-N 167256 US9073881, 5 Eukaryotic translation initiation factor 4E 23000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167256&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536081 312321112 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310908 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1cccc(c1)C(F)(F)F InChI=1S/C23H13F3N2O4S/c24-23(25,26)15-5-3-4-13(10-15)19-12-33-21(27-19)14-8-9-16(18(11-14)22(29)30)17-6-1-2-7-20(17)28(31)32/h1-12H,(H,29,30) CMRWMJUOGCXATN-UHFFFAOYSA-N 167257 US9073881, 6 Eukaryotic translation initiation factor 4E 8300 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167257&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536083 312321113 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310909 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(cc1)C(F)(F)F InChI=1S/C23H13F3N2O4S/c24-23(25,26)15-8-5-13(6-9-15)19-12-33-21(27-19)14-7-10-16(18(11-14)22(29)30)17-3-1-2-4-20(17)28(31)32/h1-12H,(H,29,30) UJWSOVYRPWSKAV-UHFFFAOYSA-N 167258 US9073881, 7 Eukaryotic translation initiation factor 4E 2400 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167258&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536345 312321114 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310910 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C24H12F6N2O4S/c25-23(26,27)14-7-13(8-15(10-14)24(28,29)30)19-11-37-21(31-19)12-5-6-16(18(9-12)22(33)34)17-3-1-2-4-20(17)32(35)36/h1-11H,(H,33,34) JSBRKEQTDDBOJY-UHFFFAOYSA-N 167259 US9073881, 8 Eukaryotic translation initiation factor 4E 2500 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167259&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679841 312321115 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310911 Cc1cc(ccc1Cl)-c1csc(n1)-c1ccc(c(c1)C(O)=O)-c1ccccc1[N+]([O-])=O InChI=1S/C23H15ClN2O4S/c1-13-10-14(7-9-19(13)24)20-12-31-22(25-20)15-6-8-16(18(11-15)23(27)28)17-4-2-3-5-21(17)26(29)30/h2-12H,1H3,(H,27,28) UIYAJQXLAFNAOY-UHFFFAOYSA-N 167260 US9073881, 9 Eukaryotic translation initiation factor 4E 5900 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167260&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536348 312321116 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310912 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(Cl)cc1Cl InChI=1S/C22H12Cl2N2O4S/c23-13-6-8-16(18(24)10-13)19-11-31-21(25-19)12-5-7-14(17(9-12)22(27)28)15-3-1-2-4-20(15)26(29)30/h1-11H,(H,27,28) QLCWPWKDYFTWTP-UHFFFAOYSA-N 167261 US9073881, 10 Eukaryotic translation initiation factor 4E 3500 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167261&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537195 312321117 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310913 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccccc1Cl InChI=1S/C22H13ClN2O4S/c23-18-7-3-1-6-16(18)19-12-30-21(24-19)13-9-10-14(17(11-13)22(26)27)15-5-2-4-8-20(15)25(28)29/h1-12H,(H,26,27) FCFWLQXTCNEULY-UHFFFAOYSA-N 167262 US9073881, 11 Eukaryotic translation initiation factor 4E 12000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167262&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536349 312321118 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310914 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1cc(Cl)ccc1Cl InChI=1S/C22H12Cl2N2O4S/c23-13-6-8-18(24)17(10-13)19-11-31-21(25-19)12-5-7-14(16(9-12)22(27)28)15-3-1-2-4-20(15)26(29)30/h1-11H,(H,27,28) LGAIHEOTVSZWBB-UHFFFAOYSA-N 167263 US9073881, 12 Eukaryotic translation initiation factor 4E 2900 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167263&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537482 312321119 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310915 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(Cl)cc1 InChI=1S/C22H13ClN2O4S/c23-15-8-5-13(6-9-15)19-12-30-21(24-19)14-7-10-16(18(11-14)22(26)27)17-3-1-2-4-20(17)25(28)29/h1-12H,(H,26,27) WXKGWNWRKFMYEK-UHFFFAOYSA-N 167264 US9073881, 13 Eukaryotic translation initiation factor 4E 5200 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167264&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536626 312321120 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310916 OC(=O)c1cc(ccc1-c1cc(Cl)ccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H11Cl3N2O4S/c23-13-3-6-20(27(30)31)15(9-13)14-4-1-12(7-16(14)22(28)29)21-26-19(10-32-21)11-2-5-17(24)18(25)8-11/h1-10H,(H,28,29) PAVXUBAPGJCFRR-UHFFFAOYSA-N 167265 US9073881, 14 Eukaryotic translation initiation factor 4E 1300 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167265&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538879 312321121 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310917 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H12Cl2N2O4S/c23-17-8-6-12(10-18(17)24)19-11-31-21(25-19)13-5-7-14(16(9-13)22(27)28)15-3-1-2-4-20(15)26(29)30/h1-11H,(H,27,28) BMXHPMQKEMARLG-UHFFFAOYSA-N 167266 US9073881, 15::US9073881, 16 Eukaryotic translation initiation factor 4E 2800 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167266&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71506886 312321122 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310918 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H12Cl2N2O4S/c23-17-8-6-12(10-18(17)24)19-11-31-21(25-19)13-5-7-14(16(9-13)22(27)28)15-3-1-2-4-20(15)26(29)30/h1-11H,(H,27,28) BMXHPMQKEMARLG-UHFFFAOYSA-N 167266 US9073881, 15::US9073881, 16 Eukaryotic translation initiation factor 4E 500 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167266&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71506886 312321122 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310919 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1cccc(Cl)c1 InChI=1S/C22H13ClN2O4S/c23-15-5-3-4-13(10-15)19-12-30-21(24-19)14-8-9-16(18(11-14)22(26)27)17-6-1-2-7-20(17)25(28)29/h1-12H,(H,26,27) ORXGFRNEQDCIKZ-UHFFFAOYSA-N 167268 US9073881, 17 Eukaryotic translation initiation factor 4E 3100 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167268&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536627 312321123 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310920 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(F)c(Cl)c1 InChI=1S/C22H12ClFN2O4S/c23-17-10-12(6-8-18(17)24)19-11-31-21(25-19)13-5-7-14(16(9-13)22(27)28)15-3-1-2-4-20(15)26(29)30/h1-11H,(H,27,28) JZZZMGRKNOOPQC-UHFFFAOYSA-N 167269 US9073881, 18 Eukaryotic translation initiation factor 4E 5000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167269&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536628 312321124 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310921 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(F)cc1F InChI=1S/C22H12F2N2O4S/c23-13-6-8-16(18(24)10-13)19-11-31-21(25-19)12-5-7-14(17(9-12)22(27)28)15-3-1-2-4-20(15)26(29)30/h1-11H,(H,27,28) NXQFSZVYVVOZFW-UHFFFAOYSA-N 167270 US9073881, 19 Eukaryotic translation initiation factor 4E 13000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167270&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537196 312321125 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310922 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1c(F)cccc1F InChI=1S/C22H12F2N2O4S/c23-16-5-3-6-17(24)20(16)18-11-31-21(25-18)12-8-9-13(15(10-12)22(27)28)14-4-1-2-7-19(14)26(29)30/h1-11H,(H,27,28) AJLRKFDSFNUKCA-UHFFFAOYSA-N 167271 US9073881, 20 Eukaryotic translation initiation factor 4E >80000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167271&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538603 312321126 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310923 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccccc1F InChI=1S/C22H13FN2O4S/c23-18-7-3-1-6-16(18)19-12-30-21(24-19)13-9-10-14(17(11-13)22(26)27)15-5-2-4-8-20(15)25(28)29/h1-12H,(H,26,27) HXVAWEPENFZEBS-UHFFFAOYSA-N 167272 US9073881, 21 Eukaryotic translation initiation factor 4E 14000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167272&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536629 312321127 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310924 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1cc(F)cc(F)c1 InChI=1S/C22H12F2N2O4S/c23-14-7-13(8-15(24)10-14)19-11-31-21(25-19)12-5-6-16(18(9-12)22(27)28)17-3-1-2-4-20(17)26(29)30/h1-11H,(H,27,28) IGQOVOZZTMCSPZ-UHFFFAOYSA-N 167273 US9073881, 22 Eukaryotic translation initiation factor 4E 11000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167273&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679843 312321128 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310925 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(F)c(F)c1 InChI=1S/C22H12F2N2O4S/c23-17-8-6-12(10-18(17)24)19-11-31-21(25-19)13-5-7-14(16(9-13)22(27)28)15-3-1-2-4-20(15)26(29)30/h1-11H,(H,27,28) HOGIIWYEMLBZFV-UHFFFAOYSA-N 167274 US9073881, 23 Eukaryotic translation initiation factor 4E 20000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167274&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538881 312321129 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310926 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1cccc(F)c1 InChI=1S/C22H13FN2O4S/c23-15-5-3-4-13(10-15)19-12-30-21(24-19)14-8-9-16(18(11-14)22(26)27)17-6-1-2-7-20(17)25(28)29/h1-12H,(H,26,27) IRNHWJZMWSALDJ-UHFFFAOYSA-N 167275 US9073881, 24 Eukaryotic translation initiation factor 4E 2600 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167275&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536630 312321130 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310927 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(Br)s1 InChI=1S/C20H11BrN2O4S2/c21-18-8-7-17(29-18)15-10-28-19(22-15)11-5-6-12(14(9-11)20(24)25)13-3-1-2-4-16(13)23(26)27/h1-10H,(H,24,25) BOTKASBVGNGOGK-UHFFFAOYSA-N 167276 US9073881, 25 Eukaryotic translation initiation factor 4E 4400 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167276&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536631 312321131 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310928 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1cccc(Br)c1 InChI=1S/C22H13BrN2O4S/c23-15-5-3-4-13(10-15)19-12-30-21(24-19)14-8-9-16(18(11-14)22(26)27)17-6-1-2-7-20(17)25(28)29/h1-12H,(H,26,27) QQYQWPFBCJONBM-UHFFFAOYSA-N 167277 US9073881, 26 Eukaryotic translation initiation factor 4E 3000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167277&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536901 312321132 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310929 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(Br)cc1 InChI=1S/C22H13BrN2O4S/c23-15-8-5-13(6-9-15)19-12-30-21(24-19)14-7-10-16(18(11-14)22(26)27)17-3-1-2-4-20(17)25(28)29/h1-12H,(H,26,27) NWMKMUSZICCRJT-UHFFFAOYSA-N 167278 US9073881, 27 Eukaryotic translation initiation factor 4E 4000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167278&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536903 312321133 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310930 COc1ccc(-c2ccc(cc2C(O)=O)-c2nc(cs2)-c2ccc(Cl)c(Cl)c2)c(c1)[N+]([O-])=O InChI=1S/C23H14Cl2N2O5S/c1-32-14-4-6-16(21(10-14)27(30)31)15-5-2-13(8-17(15)23(28)29)22-26-20(11-33-22)12-3-7-18(24)19(25)9-12/h2-11H,1H3,(H,28,29) NTXJJIUAONRUHZ-UHFFFAOYSA-N 167279 US9073881, 28 Eukaryotic translation initiation factor 4E 3200 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167279&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538880 312321134 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310931 COc1ccc(-c2csc(n2)-c2ccc(c(c2)C(O)=O)-c2ccccc2[N+]([O-])=O)c(F)c1 InChI=1S/C23H15FN2O5S/c1-31-14-7-9-17(19(24)11-14)20-12-32-22(25-20)13-6-8-15(18(10-13)23(27)28)16-4-2-3-5-21(16)26(29)30/h2-12H,1H3,(H,27,28) OETXXTDQPXASRA-UHFFFAOYSA-N 167280 US9073881, 29 Eukaryotic translation initiation factor 4E 19000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167280&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536902 312321135 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310932 COc1ccccc1-c1csc(n1)-c1ccc(c(c1)C(O)=O)-c1ccccc1[N+]([O-])=O InChI=1S/C23H16N2O5S/c1-30-21-9-5-3-7-17(21)19-13-31-22(24-19)14-10-11-15(18(12-14)23(26)27)16-6-2-4-8-20(16)25(28)29/h2-13H,1H3,(H,26,27) CMSWMVLBYCZBAY-UHFFFAOYSA-N 167281 US9073881, 30 Eukaryotic translation initiation factor 4E 14000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167281&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536904 312321136 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310933 COc1cccc(c1)-c1csc(n1)-c1ccc(c(c1)C(O)=O)-c1ccccc1[N+]([O-])=O InChI=1S/C23H16N2O5S/c1-30-16-6-4-5-14(11-16)20-13-31-22(24-20)15-9-10-17(19(12-15)23(26)27)18-7-2-3-8-21(18)25(28)29/h2-13H,1H3,(H,26,27) PHDMEJPLUAARAR-UHFFFAOYSA-N 167282 US9073881, 31 Eukaryotic translation initiation factor 4E 18000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167282&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536905 312321137 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310934 COc1ccc(cc1)-c1csc(n1)-c1ccc(c(c1)C(O)=O)-c1ccccc1[N+]([O-])=O InChI=1S/C23H16N2O5S/c1-30-16-9-6-14(7-10-16)20-13-31-22(24-20)15-8-11-17(19(12-15)23(26)27)18-4-2-3-5-21(18)25(28)29/h2-13H,1H3,(H,26,27) DIGXHURTVBQAEP-UHFFFAOYSA-N 167283 US9073881, 32 Eukaryotic translation initiation factor 4E 8300 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167283&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537191 312321138 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310935 CS(=O)(=O)c1ccc(cc1)-c1csc(n1)-c1ccc(c(c1)C(O)=O)-c1ccccc1[N+]([O-])=O InChI=1S/C23H16N2O6S2/c1-33(30,31)16-9-6-14(7-10-16)20-13-32-22(24-20)15-8-11-17(19(12-15)23(26)27)18-4-2-3-5-21(18)25(28)29/h2-13H,1H3,(H,26,27) CVINBASQEVEALR-UHFFFAOYSA-N 167284 US9073881, 33 Eukaryotic translation initiation factor 4E >80000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167284&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536906 312321139 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310936 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc2OCCOc2c1 InChI=1S/C24H16N2O6S/c27-24(28)18-11-15(5-7-16(18)17-3-1-2-4-20(17)26(29)30)23-25-19(13-33-23)14-6-8-21-22(12-14)32-10-9-31-21/h1-8,11-13H,9-10H2,(H,27,28) VTNKYDKBIMDTRG-UHFFFAOYSA-N 167285 US9073881, 34 Eukaryotic translation initiation factor 4E 33000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167285&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536350 312321140 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310937 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1cccc(c1)C#N InChI=1S/C23H13N3O4S/c24-12-14-4-3-5-15(10-14)20-13-31-22(25-20)16-8-9-17(19(11-16)23(27)28)18-6-1-2-7-21(18)26(29)30/h1-11,13H,(H,27,28) XCUHLMBBWKAINM-UHFFFAOYSA-N 167286 US9073881, 35 Eukaryotic translation initiation factor 4E 28000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167286&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537192 312321141 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310938 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccc(cc1)C#N InChI=1S/C23H13N3O4S/c24-12-14-5-7-15(8-6-14)20-13-31-22(25-20)16-9-10-17(19(11-16)23(27)28)18-3-1-2-4-21(18)26(29)30/h1-11,13H,(H,27,28) YUAJRZSINAZZIT-UHFFFAOYSA-N 167287 US9073881, 36 Eukaryotic translation initiation factor 4E 30000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167287&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537193 312321142 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310939 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccccn1 InChI=1S/C21H13N3O4S/c25-21(26)16-11-13(20-23-18(12-29-20)17-6-3-4-10-22-17)8-9-14(16)15-5-1-2-7-19(15)24(27)28/h1-12H,(H,25,26) NNNCNEANGFACKT-UHFFFAOYSA-N 167288 US9073881, 37 Eukaryotic translation initiation factor 4E >80000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167288&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535811 312321143 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310940 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1cccnc1 InChI=1S/C21H13N3O4S/c25-21(26)17-10-13(20-23-18(12-29-20)14-4-3-9-22-11-14)7-8-15(17)16-5-1-2-6-19(16)24(27)28/h1-12H,(H,25,26) DJOHGXCDBSAMDK-UHFFFAOYSA-N 167289 US9073881, 38 Eukaryotic translation initiation factor 4E >80000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167289&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535810 312321144 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310941 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccncc1 InChI=1S/C21H13N3O4S/c25-21(26)17-11-14(20-23-18(12-29-20)13-7-9-22-10-8-13)5-6-15(17)16-3-1-2-4-19(16)24(27)28/h1-12H,(H,25,26) FTCODCYRSIXLRT-UHFFFAOYSA-N 167290 US9073881, 39 Eukaryotic translation initiation factor 4E >80000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167290&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535814 312321145 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310942 Cc1ccc(-c2csc(n2)-c2ccc(c(c2)C(O)=O)-c2ccccc2[N+]([O-])=O)c(C)c1 InChI=1S/C24H18N2O4S/c1-14-7-9-17(15(2)11-14)21-13-31-23(25-21)16-8-10-18(20(12-16)24(27)28)19-5-3-4-6-22(19)26(29)30/h3-13H,1-2H3,(H,27,28) PXPWQOCOBFJWLB-UHFFFAOYSA-N 167291 US9073881, 40 Eukaryotic translation initiation factor 4E 4200 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167291&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537481 312321146 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310943 Cc1ccc(cc1)-c1csc(n1)-c1ccc(c(c1)C(O)=O)-c1ccccc1[N+]([O-])=O InChI=1S/C23H16N2O4S/c1-14-6-8-15(9-7-14)20-13-30-22(24-20)16-10-11-17(19(12-16)23(26)27)18-4-2-3-5-21(18)25(28)29/h2-13H,1H3,(H,26,27) SICJDIDKRXMVFS-UHFFFAOYSA-N 167292 US9073881, 41 Eukaryotic translation initiation factor 4E 13000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167292&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536080 312321147 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310944 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccsc1 InChI=1S/C20H12N2O4S2/c23-20(24)16-9-12(19-21-17(11-28-19)13-7-8-27-10-13)5-6-14(16)15-3-1-2-4-18(15)22(25)26/h1-11H,(H,23,24) QGIRFVZDQGTGDQ-UHFFFAOYSA-N 167293 US9073881, 42 Eukaryotic translation initiation factor 4E 18000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167293&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536082 312321148 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310945 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1ccccc1 InChI=1S/C22H14N2O4S/c25-22(26)18-12-15(21-23-19(13-29-21)14-6-2-1-3-7-14)10-11-16(18)17-8-4-5-9-20(17)24(27)28/h1-13H,(H,25,26) NXURTXJIVXGDQK-UHFFFAOYSA-N 167294 US9073881, 43 Eukaryotic translation initiation factor 4E 26000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167294&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536084 312321149 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310946 OC(=O)c1cc(ccc1-c1ccccc1[N+]([O-])=O)-c1nc(cs1)-c1cccs1 InChI=1S/C20H12N2O4S2/c23-20(24)15-10-12(19-21-16(11-28-19)18-6-3-9-27-18)7-8-13(15)14-4-1-2-5-17(14)22(25)26/h1-11H,(H,23,24) MXXSDMRTJCUXBJ-UHFFFAOYSA-N 167295 US9073881, 44 Eukaryotic translation initiation factor 4E 12000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167295&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536346 312321150 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310947 OC(=O)c1cc(ccc1-c1ccc(cc1)[N+]([O-])=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H12Cl2N2O4S/c23-18-8-4-13(10-19(18)24)20-11-31-21(25-20)14-3-7-16(17(9-14)22(27)28)12-1-5-15(6-2-12)26(29)30/h1-11H,(H,27,28) FLTDSEFLYYGPFG-UHFFFAOYSA-N 167296 US9073881, 45 Eukaryotic translation initiation factor 4E 4100 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167296&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538882 312321151 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310948 OC(=O)c1cc(ccc1-c1cccc(c1)[N+]([O-])=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H12Cl2N2O4S/c23-18-7-5-13(10-19(18)24)20-11-31-21(25-20)14-4-6-16(17(9-14)22(27)28)12-2-1-3-15(8-12)26(29)30/h1-11H,(H,27,28) IZKZPKQDVQNBPQ-UHFFFAOYSA-N 167297 US9073881, 46 Eukaryotic translation initiation factor 4E 3800 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167297&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538883 312321152 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310949 CCN(CC)CCCNC(=O)c1ccc(cc1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C30H29Cl2N3O3S/c1-3-35(4-2)15-5-14-33-28(36)20-8-6-19(7-9-20)23-12-10-22(16-24(23)30(37)38)29-34-27(18-39-29)21-11-13-25(31)26(32)17-21/h6-13,16-18H,3-5,14-15H2,1-2H3,(H,33,36)(H,37,38) ZUQBQNLJJCQHNC-UHFFFAOYSA-N 167298 US9073881, 47 Eukaryotic translation initiation factor 4E >80000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167298&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71534654 312321153 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310950 CCN(C)CCCNC(=O)c1ccc(cc1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C29H27Cl2N3O3S/c1-3-34(2)14-4-13-32-27(35)19-7-5-18(6-8-19)22-11-9-21(15-23(22)29(36)37)28-33-26(17-38-28)20-10-12-24(30)25(31)16-20/h5-12,15-17H,3-4,13-14H2,1-2H3,(H,32,35)(H,36,37) KLOMNNNWEVKTNS-UHFFFAOYSA-N 167299 US9073881, 48 Eukaryotic translation initiation factor 4E >80000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167299&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 89461213 312321154 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310951 CN(C)CCNC(=O)c1ccc(cc1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C27H23Cl2N3O3S/c1-32(2)12-11-30-25(33)17-5-3-16(4-6-17)20-9-7-19(13-21(20)27(34)35)26-31-24(15-36-26)18-8-10-22(28)23(29)14-18/h3-10,13-15H,11-12H2,1-2H3,(H,30,33)(H,34,35) XTWUXSBUDJAUTB-UHFFFAOYSA-N 167300 US9073881, 49 Eukaryotic translation initiation factor 4E >80000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167300&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71534653 312321155 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310952 Cn1nccc1CNC(=O)c1ccc(cc1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C28H20Cl2N4O3S/c1-34-20(10-11-32-34)14-31-26(35)17-4-2-16(3-5-17)21-8-6-19(12-22(21)28(36)37)27-33-25(15-38-27)18-7-9-23(29)24(30)13-18/h2-13,15H,14H2,1H3,(H,31,35)(H,36,37) IBGCHEOOIZCRIM-UHFFFAOYSA-N 167301 US9073881, 50 Eukaryotic translation initiation factor 4E 7800 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167301&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71534656 312321156 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310953 CN1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C29H25Cl2N3O3S/c1-34-12-10-21(11-13-34)32-27(35)18-4-2-17(3-5-18)22-8-6-20(14-23(22)29(36)37)28-33-26(16-38-28)19-7-9-24(30)25(31)15-19/h2-9,14-16,21H,10-13H2,1H3,(H,32,35)(H,36,37) MBOVQXVVEBDHKK-UHFFFAOYSA-N 167302 US9073881, 51 Eukaryotic translation initiation factor 4E >80000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167302&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679845 312321157 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310954 CC(=O)N1CCC(CC1)NC(=O)c1ccc(cc1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C30H25Cl2N3O4S/c1-17(36)35-12-10-22(11-13-35)33-28(37)19-4-2-18(3-5-19)23-8-6-21(14-24(23)30(38)39)29-34-27(16-40-29)20-7-9-25(31)26(32)15-20/h2-9,14-16,22H,10-13H2,1H3,(H,33,37)(H,38,39) ZYCNOKBGTDFHEK-UHFFFAOYSA-N 167303 US9073881, 52 Eukaryotic translation initiation factor 4E 10000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167303&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71534655 312321158 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310955 CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C28H23Cl2N3O3S/c1-32-10-12-33(13-11-32)27(34)18-4-2-17(3-5-18)21-8-6-20(14-22(21)28(35)36)26-31-25(16-37-26)19-7-9-23(29)24(30)15-19/h2-9,14-16H,10-13H2,1H3,(H,35,36) UDDMQDFTSIHDMQ-UHFFFAOYSA-N 167304 US9073881, 53 Eukaryotic translation initiation factor 4E >80000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167304&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71534657 312321159 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310956 CC(=O)N1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C29H23Cl2N3O4S/c1-17(35)33-10-12-34(13-11-33)28(36)19-4-2-18(3-5-19)22-8-6-21(14-23(22)29(37)38)27-32-26(16-39-27)20-7-9-24(30)25(31)15-20/h2-9,14-16H,10-13H2,1H3,(H,37,38) QEFBVOQAWKASGC-UHFFFAOYSA-N 167305 US9073881, 54 Eukaryotic translation initiation factor 4E 21000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167305&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537483 312321160 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310957 OC1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C28H22Cl2N2O4S/c29-23-8-6-18(14-24(23)30)25-15-37-26(31-25)19-5-7-21(22(13-19)28(35)36)16-1-3-17(4-2-16)27(34)32-11-9-20(33)10-12-32/h1-8,13-15,20,33H,9-12H2,(H,35,36) PSCWCQJSKDJKSM-UHFFFAOYSA-N 167306 US9073881, 55 Eukaryotic translation initiation factor 4E 15000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167306&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537773 312321161 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310958 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)N1CCOCC1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C27H20Cl2N2O4S/c28-22-8-6-18(14-23(22)29)24-15-36-25(30-24)19-5-7-20(21(13-19)27(33)34)16-1-3-17(4-2-16)26(32)31-9-11-35-12-10-31/h1-8,13-15H,9-12H2,(H,33,34) ADDPNMAHURUDHE-UHFFFAOYSA-N 167307 US9073881, 56 Eukaryotic translation initiation factor 4E 15000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167307&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537772 312321162 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310959 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)N1CCCC1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C27H20Cl2N2O3S/c28-22-10-8-18(14-23(22)29)24-15-35-25(30-24)19-7-9-20(21(13-19)27(33)34)16-3-5-17(6-4-16)26(32)31-11-1-2-12-31/h3-10,13-15H,1-2,11-12H2,(H,33,34) DJYPTHUNDKQHLI-UHFFFAOYSA-N 167308 US9073881, 57 Eukaryotic translation initiation factor 4E 4300 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167308&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537485 312321163 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310960 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCCCN1CCOCC1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C30H27Cl2N3O4S/c31-25-9-7-21(17-26(25)32)27-18-40-29(34-27)22-6-8-23(24(16-22)30(37)38)19-2-4-20(5-3-19)28(36)33-10-1-11-35-12-14-39-15-13-35/h2-9,16-18H,1,10-15H2,(H,33,36)(H,37,38) AYHUWYHEOPREIH-UHFFFAOYSA-N 167309 US9073881, 58 Eukaryotic translation initiation factor 4E >80000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167309&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537776 312321164 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310961 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCCN1CCOCC1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C29H25Cl2N3O4S/c30-24-8-6-20(16-25(24)31)26-17-39-28(33-26)21-5-7-22(23(15-21)29(36)37)18-1-3-19(4-2-18)27(35)32-9-10-34-11-13-38-14-12-34/h1-8,15-17H,9-14H2,(H,32,35)(H,36,37) SVEGOQPIJKWELG-UHFFFAOYSA-N 167310 US9073881, 59 Eukaryotic translation initiation factor 4E >80000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167310&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538049 312321165 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310962 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCC1CCOCC1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C29H24Cl2N2O4S/c30-24-8-6-20(14-25(24)31)26-16-38-28(33-26)21-5-7-22(23(13-21)29(35)36)18-1-3-19(4-2-18)27(34)32-15-17-9-11-37-12-10-17/h1-8,13-14,16-17H,9-12,15H2,(H,32,34)(H,35,36) MEYMJYDNEAZQGP-UHFFFAOYSA-N 167311 US9073881, 60 Eukaryotic translation initiation factor 4E 8900 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167311&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538050 312321166 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310963 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCC1CCCO1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C28H22Cl2N2O4S/c29-23-10-8-18(13-24(23)30)25-15-37-27(32-25)19-7-9-21(22(12-19)28(34)35)16-3-5-17(6-4-16)26(33)31-14-20-2-1-11-36-20/h3-10,12-13,15,20H,1-2,11,14H2,(H,31,33)(H,34,35) YLMYXHRYEGMGAK-UHFFFAOYSA-N 167312 US9073881, 61 Eukaryotic translation initiation factor 4E 5500 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167312&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538328 312321167 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310964 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NC1CCOC1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C27H20Cl2N2O4S/c28-22-8-6-17(12-23(22)29)24-14-36-26(31-24)18-5-7-20(21(11-18)27(33)34)15-1-3-16(4-2-15)25(32)30-19-9-10-35-13-19/h1-8,11-12,14,19H,9-10,13H2,(H,30,32)(H,33,34) SGRWUSIHMIWBGQ-UHFFFAOYSA-N 167313 US9073881, 62 Eukaryotic translation initiation factor 4E 7700 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167313&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538327 312321168 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310965 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NC1CCOCC1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C28H22Cl2N2O4S/c29-23-8-6-18(14-24(23)30)25-15-37-27(32-25)19-5-7-21(22(13-19)28(34)35)16-1-3-17(4-2-16)26(33)31-20-9-11-36-12-10-20/h1-8,13-15,20H,9-12H2,(H,31,33)(H,34,35) YNSFCMCHDNGUFX-UHFFFAOYSA-N 167314 US9073881, 63 Eukaryotic translation initiation factor 4E 5700 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167314&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538326 312321169 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310966 COc1ccc(CNC(=O)c2ccc(cc2)-c2ccc(cc2C(O)=O)-c2nc(cs2)-c2ccc(Cl)c(Cl)c2)cc1 InChI=1S/C31H22Cl2N2O4S/c1-39-23-10-2-18(3-11-23)16-34-29(36)20-6-4-19(5-7-20)24-12-8-22(14-25(24)31(37)38)30-35-28(17-40-30)21-9-13-26(32)27(33)15-21/h2-15,17H,16H2,1H3,(H,34,36)(H,37,38) VEMYLYOTAXAPGS-UHFFFAOYSA-N 167315 US9073881, 64 Eukaryotic translation initiation factor 4E 2000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167315&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538599 312321170 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310967 COc1cccc(CNC(=O)c2ccc(cc2)-c2ccc(cc2C(O)=O)-c2nc(cs2)-c2ccc(Cl)c(Cl)c2)c1 InChI=1S/C31H22Cl2N2O4S/c1-39-23-4-2-3-18(13-23)16-34-29(36)20-7-5-19(6-8-20)24-11-9-22(14-25(24)31(37)38)30-35-28(17-40-30)21-10-12-26(32)27(33)15-21/h2-15,17H,16H2,1H3,(H,34,36)(H,37,38) SNHWIUDCZHAFJX-UHFFFAOYSA-N 167316 US9073881, 65 Eukaryotic translation initiation factor 4E 1300 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167316&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538330 312321171 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310968 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCCc1cccnc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C30H21Cl2N3O3S/c31-25-10-8-21(15-26(25)32)27-17-39-29(35-27)22-7-9-23(24(14-22)30(37)38)19-3-5-20(6-4-19)28(36)34-13-11-18-2-1-12-33-16-18/h1-10,12,14-17H,11,13H2,(H,34,36)(H,37,38) HJKQGCUYLGRYHK-UHFFFAOYSA-N 167317 US9073881, 66 Eukaryotic translation initiation factor 4E 9600 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167317&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538601 312321172 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310969 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCCc1ccccc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C31H22Cl2N2O3S/c32-26-13-11-22(17-27(26)33)28-18-39-30(35-28)23-10-12-24(25(16-23)31(37)38)20-6-8-21(9-7-20)29(36)34-15-14-19-4-2-1-3-5-19/h1-13,16-18H,14-15H2,(H,34,36)(H,37,38) NAYOHIXUMXMHKW-UHFFFAOYSA-N 167318 US9073881, 67 Eukaryotic translation initiation factor 4E 2900 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167318&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71534957 312321173 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310970 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCc1cccnc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C29H19Cl2N3O3S/c30-24-10-8-20(13-25(24)31)26-16-38-28(34-26)21-7-9-22(23(12-21)29(36)37)18-3-5-19(6-4-18)27(35)33-15-17-2-1-11-32-14-17/h1-14,16H,15H2,(H,33,35)(H,36,37) CDFNYDOYKKSGEQ-UHFFFAOYSA-N 167319 US9073881, 68 Eukaryotic translation initiation factor 4E 11000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167319&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537484 312321174 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310971 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCc1ccncc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C29H19Cl2N3O3S/c30-24-8-6-20(14-25(24)31)26-16-38-28(34-26)21-5-7-22(23(13-21)29(36)37)18-1-3-19(4-2-18)27(35)33-15-17-9-11-32-12-10-17/h1-14,16H,15H2,(H,33,35)(H,36,37) HTGPZNZLEQFHCT-UHFFFAOYSA-N 167320 US9073881, 69 Eukaryotic translation initiation factor 4E 7100 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167320&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537774 312321175 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310972 Cc1cccc(CNC(=O)c2ccc(cc2)-c2ccc(cc2C(O)=O)-c2nc(cs2)-c2ccc(Cl)c(Cl)c2)c1 InChI=1S/C31H22Cl2N2O3S/c1-18-3-2-4-19(13-18)16-34-29(36)21-7-5-20(6-8-21)24-11-9-23(14-25(24)31(37)38)30-35-28(17-39-30)22-10-12-26(32)27(33)15-22/h2-15,17H,16H2,1H3,(H,34,36)(H,37,38) COBXIPLANRIJSZ-UHFFFAOYSA-N 167321 US9073881, 70 Eukaryotic translation initiation factor 4E 1700 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167321&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537775 312321176 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310973 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCc1cccc(c1)C(F)(F)F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C31H19Cl2F3N2O3S/c32-25-11-9-20(14-26(25)33)27-16-42-29(38-27)21-8-10-23(24(13-21)30(40)41)18-4-6-19(7-5-18)28(39)37-15-17-2-1-3-22(12-17)31(34,35)36/h1-14,16H,15H2,(H,37,39)(H,40,41) IPTAIKAYCKAYIJ-UHFFFAOYSA-N 167322 US9073881, 71 Eukaryotic translation initiation factor 4E 3200 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167322&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538048 312321177 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310974 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCc1ccc(F)cc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C30H19Cl2FN2O3S/c31-25-12-8-20(14-26(25)32)27-16-39-29(35-27)21-7-11-23(24(13-21)30(37)38)18-3-5-19(6-4-18)28(36)34-15-17-1-9-22(33)10-2-17/h1-14,16H,15H2,(H,34,36)(H,37,38) HZAOILCKBDCXGX-UHFFFAOYSA-N 167323 US9073881, 72 Eukaryotic translation initiation factor 4E 1500 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167323&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538051 312321178 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310975 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCc1cccc(F)c1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C30H19Cl2FN2O3S/c31-25-11-9-20(14-26(25)32)27-16-39-29(35-27)21-8-10-23(24(13-21)30(37)38)18-4-6-19(7-5-18)28(36)34-15-17-2-1-3-22(33)12-17/h1-14,16H,15H2,(H,34,36)(H,37,38) PLUJFNVCCUEUAR-UHFFFAOYSA-N 167324 US9073881, 73 Eukaryotic translation initiation factor 4E 2100 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167324&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538052 312321179 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310976 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCc1ccccc1F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C30H19Cl2FN2O3S/c31-24-12-10-19(14-25(24)32)27-16-39-29(35-27)20-9-11-22(23(13-20)30(37)38)17-5-7-18(8-6-17)28(36)34-15-21-3-1-2-4-26(21)33/h1-14,16H,15H2,(H,34,36)(H,37,38) QRBYAIFWDJNTFP-UHFFFAOYSA-N 167325 US9073881, 74 Eukaryotic translation initiation factor 4E 2500 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167325&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538329 312321180 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310977 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCc1cccs1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C28H18Cl2N2O3S2/c29-23-10-8-18(13-24(23)30)25-15-37-27(32-25)19-7-9-21(22(12-19)28(34)35)16-3-5-17(6-4-16)26(33)31-14-20-2-1-11-36-20/h1-13,15H,14H2,(H,31,33)(H,34,35) LAXIVIVLNIZIAG-UHFFFAOYSA-N 167326 US9073881, 75 Eukaryotic translation initiation factor 4E 3100 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167326&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71538600 312321181 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310978 OC(=O)c1cc(ccc1-c1ccc(cc1)C(=O)NCc1ccccc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C30H20Cl2N2O3S/c31-25-13-11-21(15-26(25)32)27-17-38-29(34-27)22-10-12-23(24(14-22)30(36)37)19-6-8-20(9-7-19)28(35)33-16-18-4-2-1-3-5-18/h1-15,17H,16H2,(H,33,35)(H,36,37) OEOMDVPDDSABLE-UHFFFAOYSA-N 167327 US9073881, 76 Eukaryotic translation initiation factor 4E 2300 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167327&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71534958 312321182 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310979 NC(=O)c1ncccc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H13Cl2N3O3S/c23-16-6-4-11(9-17(16)24)18-10-31-21(27-18)12-3-5-13(15(8-12)22(29)30)14-2-1-7-26-19(14)20(25)28/h1-10H,(H2,25,28)(H,29,30) NUWUMCFYDLRZMA-UHFFFAOYSA-N 167328 US9073881, 77 Eukaryotic translation initiation factor 4E 1300 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167328&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71534959 312321183 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310980 Cc1cc(ccc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1)C(O)=O InChI=1S/C24H15Cl2NO4S/c1-12-8-15(23(28)29)3-5-16(12)17-6-2-14(9-18(17)24(30)31)22-27-21(11-32-22)13-4-7-19(25)20(26)10-13/h2-11H,1H3,(H,28,29)(H,30,31) PBPLMMOARXHJBO-UHFFFAOYSA-N 167329 US9073881, 78::US9073881, 79 Eukaryotic translation initiation factor 4E 1900 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167329&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536347 312321184 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310981 Cc1cc(ccc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1)C(O)=O InChI=1S/C24H15Cl2NO4S/c1-12-8-15(23(28)29)3-5-16(12)17-6-2-14(9-18(17)24(30)31)22-27-21(11-32-22)13-4-7-19(25)20(26)10-13/h2-11H,1H3,(H,28,29)(H,30,31) PBPLMMOARXHJBO-UHFFFAOYSA-N 167329 US9073881, 78::US9073881, 79 Eukaryotic translation initiation factor 4E 5400 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167329&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536347 312321184 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310982 CC(NC(=O)c1ccc(cc1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1)c1ccccc1 InChI=1S/C31H22Cl2N2O3S/c1-18(19-5-3-2-4-6-19)34-29(36)21-9-7-20(8-10-21)24-13-11-23(15-25(24)31(37)38)30-35-28(17-39-30)22-12-14-26(32)27(33)16-22/h2-18H,1H3,(H,34,36)(H,37,38) NJVJKWJPINHWAL-UHFFFAOYSA-N 167330 US9073881, 80 Eukaryotic translation initiation factor 4E 970 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167330&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71534961 312321185 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310983 NC(=O)c1ccccc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H14Cl2N2O3S/c24-18-8-6-12(10-19(18)25)20-11-31-22(27-20)13-5-7-15(17(9-13)23(29)30)14-3-1-2-4-16(14)21(26)28/h1-11H,(H2,26,28)(H,29,30) ATOYKTBUDLPRIX-UHFFFAOYSA-N 167331 US9073881, 81 Eukaryotic translation initiation factor 4E 15000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167331&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535252 312321186 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310984 CCOc1ncc(cn1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H15Cl2N3O3S/c1-2-30-22-25-9-14(10-26-22)15-5-3-13(7-16(15)21(28)29)20-27-19(11-31-20)12-4-6-17(23)18(24)8-12/h3-11H,2H2,1H3,(H,28,29) LJLRAPTXMIXVMN-UHFFFAOYSA-N 167332 US9073881, 82 Eukaryotic translation initiation factor 4E 3600 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167332&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535253 312321187 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310985 COc1ncc(cn1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C21H13Cl2N3O3S/c1-29-21-24-8-13(9-25-21)14-4-2-12(6-15(14)20(27)28)19-26-18(10-30-19)11-3-5-16(22)17(23)7-11/h2-10H,1H3,(H,27,28) IGVKRCFFBLMXOI-UHFFFAOYSA-N 167333 US9073881, 83 Eukaryotic translation initiation factor 4E 14000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167333&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535254 312321188 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310986 OC(=O)c1cc(ccc1-c1cnc(O)nc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C20H11Cl2N3O3S/c21-15-4-2-10(6-16(15)22)17-9-29-18(25-17)11-1-3-13(14(5-11)19(26)27)12-7-23-20(28)24-8-12/h1-9H,(H,26,27)(H,23,24,28) AXRASHFFQIQONC-UHFFFAOYSA-N 167334 US9073881, 84 Eukaryotic translation initiation factor 4E 1200 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167334&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535256 312321189 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310987 COc1cccc(n1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H14Cl2N2O3S/c1-29-20-4-2-3-18(25-20)14-7-5-13(9-15(14)22(27)28)21-26-19(11-30-21)12-6-8-16(23)17(24)10-12/h2-11H,1H3,(H,27,28) HOYUXGWFPOFRDW-UHFFFAOYSA-N 167335 US9073881, 85 Eukaryotic translation initiation factor 4E 9700 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167335&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535255 312321190 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310988 COc1ncccc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H14Cl2N2O3S/c1-29-20-15(3-2-8-25-20)14-6-4-13(9-16(14)22(27)28)21-26-19(11-30-21)12-5-7-17(23)18(24)10-12/h2-11H,1H3,(H,27,28) WQGWWSAHJHOGGV-UHFFFAOYSA-N 167336 US9073881, 86 Eukaryotic translation initiation factor 4E 15000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167336&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535257 312321191 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310989 COc1ccc(-c2ccc(cc2C(O)=O)-c2nc(cs2)-c2ccc(Cl)c(Cl)c2)c(c1)C(F)(F)F InChI=1S/C24H14Cl2F3NO3S/c1-33-14-4-6-16(18(10-14)24(27,28)29)15-5-2-13(8-17(15)23(31)32)22-30-21(11-34-22)12-3-7-19(25)20(26)9-12/h2-11H,1H3,(H,31,32) IJDZMPGJDUCZQP-UHFFFAOYSA-N 167337 US9073881, 87 Eukaryotic translation initiation factor 4E 1300 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167337&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535529 312321192 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310990 OC(=O)c1cc(ccc1-c1cc(OC(F)(F)F)ccc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H11Cl3F3NO3S/c24-17-6-3-13(33-23(27,28)29)9-15(17)14-4-1-12(7-16(14)22(31)32)21-30-20(10-34-21)11-2-5-18(25)19(26)8-11/h1-10H,(H,31,32) XBXFWKUTBSENAG-UHFFFAOYSA-N 167338 US9073881, 88 Eukaryotic translation initiation factor 4E 600 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167338&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535531 312321193 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310991 CCOc1ccc(c(Cl)c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C24H16Cl3NO3S/c1-2-31-15-5-7-17(20(26)11-15)16-6-3-14(9-18(16)24(29)30)23-28-22(12-32-23)13-4-8-19(25)21(27)10-13/h3-12H,2H2,1H3,(H,29,30) BSIUOGGAGSEQCG-UHFFFAOYSA-N 167339 US9073881, 89 Eukaryotic translation initiation factor 4E 2000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167339&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535530 312321194 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310992 COc1cccc(Cl)c1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H14Cl3NO3S/c1-30-20-4-2-3-17(25)21(20)14-7-5-13(9-15(14)23(28)29)22-27-19(11-31-22)12-6-8-16(24)18(26)10-12/h2-11H,1H3,(H,28,29) AWWYREHKSCWEQR-UHFFFAOYSA-N 167340 US9073881, 90 Eukaryotic translation initiation factor 4E 1800 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167340&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679846 312321195 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310993 COc1cccc(c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H15Cl2NO3S/c1-29-16-4-2-3-13(9-16)17-7-5-15(10-18(17)23(27)28)22-26-21(12-30-22)14-6-8-19(24)20(25)11-14/h2-12H,1H3,(H,27,28) WOQFPLGZTMWCHX-UHFFFAOYSA-N 167341 US9073881, 91 Eukaryotic translation initiation factor 4E 5000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167341&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535533 312321196 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310994 COc1ccccc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H15Cl2NO3S/c1-29-21-5-3-2-4-16(21)15-8-6-14(10-17(15)23(27)28)22-26-20(12-30-22)13-7-9-18(24)19(25)11-13/h2-12H,1H3,(H,27,28) GXHOTJJNGMSMQS-UHFFFAOYSA-N 167342 US9073881, 92 Eukaryotic translation initiation factor 4E 4800 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167342&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535532 312321197 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310995 COc1ccc(Cl)c(c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H14Cl3NO3S/c1-30-14-4-7-18(24)16(10-14)15-5-2-13(8-17(15)23(28)29)22-27-21(11-31-22)12-3-6-19(25)20(26)9-12/h2-11H,1H3,(H,28,29) YWHKAHPCWRREGI-UHFFFAOYSA-N 167343 US9073881, 93 Eukaryotic translation initiation factor 4E 3000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167343&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679847 312321198 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310996 COc1ccc(c(Cl)c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H14Cl3NO3S/c1-30-14-4-6-16(19(25)10-14)15-5-2-13(8-17(15)23(28)29)22-27-21(11-31-22)12-3-7-18(24)20(26)9-12/h2-11H,1H3,(H,28,29) IRHVVDJEAUBVHB-UHFFFAOYSA-N 167344 US9073881, 94 Eukaryotic translation initiation factor 4E 1500 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167344&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535534 312321199 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310997 OC(=O)c1cc(ccc1-c1cc(O)ccc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H12Cl3NO3S/c23-17-6-3-13(27)9-15(17)14-4-1-12(7-16(14)22(28)29)21-26-20(10-30-21)11-2-5-18(24)19(25)8-11/h1-10,27H,(H,28,29) XOIUYJOCDXUNRO-UHFFFAOYSA-N 167345 US9073881, 95 Eukaryotic translation initiation factor 4E 3400 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167345&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679848 312321200 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310998 CC(C)c1ncncc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H17Cl2N3O2S/c1-12(2)21-17(9-26-11-27-21)15-5-3-14(7-16(15)23(29)30)22-28-20(10-31-22)13-4-6-18(24)19(25)8-13/h3-12H,1-2H3,(H,29,30) WLQQHVYFJMBVKZ-UHFFFAOYSA-N 167346 US9073881, 96 Eukaryotic translation initiation factor 4E 11000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167346&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535815 312321201 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 310999 OC(=O)c1cc(ccc1-c1cncnc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C20H11Cl2N3O2S/c21-16-4-2-11(6-17(16)22)18-9-28-19(25-18)12-1-3-14(15(5-12)20(26)27)13-7-23-10-24-8-13/h1-10H,(H,26,27) OBRASLLCYYCKSL-UHFFFAOYSA-N 60439 US9073881, 97 Eukaryotic translation initiation factor 4E 16000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60439&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535818 313084626 ZINC00146920 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311000 Cc1ncccc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H14Cl2N2O2S/c1-12-15(3-2-8-25-12)16-6-4-14(9-17(16)22(27)28)21-26-20(11-29-21)13-5-7-18(23)19(24)10-13/h2-11H,1H3,(H,27,28) MCIFPCWLXPARFN-UHFFFAOYSA-N 60440 US9073881, 98 Eukaryotic translation initiation factor 4E 4000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60440&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535816 313084627 ZINC00364807 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311001 Cc1cnccc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H14Cl2N2O2S/c1-12-10-25-7-6-15(12)16-4-2-14(8-17(16)22(27)28)21-26-20(11-29-21)13-3-5-18(23)19(24)9-13/h2-11H,1H3,(H,27,28) BBESYVLWPWGGHO-UHFFFAOYSA-N 60441 US9073881, 99 Eukaryotic translation initiation factor 4E 12000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60441&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535817 313084628 ZINC33395763 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311002 OC(=O)c1cc(ccc1-c1ccc(F)cn1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C21H11Cl2FN2O2S/c22-16-5-2-11(8-17(16)23)19-10-29-20(26-19)12-1-4-14(15(7-12)21(27)28)18-6-3-13(24)9-25-18/h1-10H,(H,27,28) LKNLKJNRMAVRBR-UHFFFAOYSA-N 167350 US9073881, 100 Eukaryotic translation initiation factor 4E 3000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167350&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679849 312321203 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311003 OC(=O)c1cc(ccc1-c1cccnc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C21H12Cl2N2O2S/c22-17-6-4-12(9-18(17)23)19-11-28-20(25-19)13-3-5-15(16(8-13)21(26)27)14-2-1-7-24-10-14/h1-11H,(H,26,27) QZWRYNBZWPIXSC-UHFFFAOYSA-N 60442 US9073881, 101 Eukaryotic translation initiation factor 4E 20000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60442&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679850 313084629 ZINC39412244 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311004 OC(=O)c1cc(ccc1-c1cncc(Cl)c1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C21H11Cl3N2O2S/c22-14-5-13(8-25-9-14)15-3-1-12(6-16(15)21(27)28)20-26-19(10-29-20)11-2-4-17(23)18(24)7-11/h1-10H,(H,27,28) SRCSIRQJTKQACU-UHFFFAOYSA-N 167352 US9073881, 102 Eukaryotic translation initiation factor 4E 5400 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167352&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679851 312321204 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311005 OC(=O)c1cc(ccc1-c1ccncc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C21H12Cl2N2O2S/c22-17-4-2-13(10-18(17)23)19-11-28-20(25-19)14-1-3-15(16(9-14)21(26)27)12-5-7-24-8-6-12/h1-11H,(H,26,27) ABFWHTKEAHAYLM-UHFFFAOYSA-N 60443 US9073881, 103 Eukaryotic translation initiation factor 4E 8500 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60443&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679852 313084630 ZINC13119010 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311006 OC(=O)c1cc(ccc1-c1cccc(n1)C#N)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H11Cl2N3O2S/c23-17-7-5-12(9-18(17)24)20-11-30-21(27-20)13-4-6-15(16(8-13)22(28)29)19-3-1-2-14(10-25)26-19/h1-9,11H,(H,28,29) VPSMSSUXVRVZKF-UHFFFAOYSA-N 167354 US9073881, 104 Eukaryotic translation initiation factor 4E 12000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167354&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679853 312321205 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311007 Cc1cc(ccc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1)C#N InChI=1S/C24H14Cl2N2O2S/c1-13-8-14(11-27)2-5-17(13)18-6-3-16(9-19(18)24(29)30)23-28-22(12-31-23)15-4-7-20(25)21(26)10-15/h2-10,12H,1H3,(H,29,30) MIARHZTWJRFUBW-UHFFFAOYSA-N 167355 US9073881, 105 Eukaryotic translation initiation factor 4E 1300 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167355&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535820 312321206 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311008 OC(=O)c1cc(ccc1-c1ccc(cc1)C#N)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H12Cl2N2O2S/c24-19-8-6-15(10-20(19)25)21-12-30-22(27-21)16-5-7-17(18(9-16)23(28)29)14-3-1-13(11-26)2-4-14/h1-10,12H,(H,28,29) NIWSWEWDRLDGAT-UHFFFAOYSA-N 167356 US9073881, 106 Eukaryotic translation initiation factor 4E 7600 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167356&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71535819 312321207 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311009 OC(=O)c1cc(ccc1-c1cccc(c1)C#N)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H12Cl2N2O2S/c24-19-7-5-15(10-20(19)25)21-12-30-22(27-21)16-4-6-17(18(9-16)23(28)29)14-3-1-2-13(8-14)11-26/h1-10,12H,(H,28,29) VUEQJJYYSDYOTF-UHFFFAOYSA-N 167357 US9073881, 107 Eukaryotic translation initiation factor 4E 3200 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167357&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679854 312321208 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311010 NC(O)c1ccc(Cl)c(c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H15Cl3N2O3S/c24-17-5-3-12(21(27)29)7-15(17)14-4-1-13(8-16(14)23(30)31)22-28-20(10-32-22)11-2-6-18(25)19(26)9-11/h1-10,21,29H,27H2,(H,30,31) OPGDPEUJYNJTET-UHFFFAOYSA-N 167403 US9073881, 108 Eukaryotic translation initiation factor 4E 3500 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167403&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 118704697 312321249 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311011 OC(=O)c1cc(ccc1-c1cc(Cl)ccc1C#N)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H11Cl3N2O2S/c24-15-4-1-14(10-27)17(9-15)16-5-2-13(7-18(16)23(29)30)22-28-21(11-31-22)12-3-6-19(25)20(26)8-12/h1-9,11H,(H,29,30) CCQYJMVSLGOZLH-UHFFFAOYSA-N 167359 US9073881, 110 Eukaryotic translation initiation factor 4E 3700 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167359&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536086 312321209 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311012 OC(=O)c1cc(ccc1-c1cc(Cl)ccc1C#N)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H11Cl3N2O2S/c24-15-4-1-14(10-27)17(9-15)16-5-2-13(7-18(16)23(29)30)22-28-21(11-31-22)12-3-6-19(25)20(26)8-12/h1-9,11H,(H,29,30) CCQYJMVSLGOZLH-UHFFFAOYSA-N 167359 US9073881, 110 Eukaryotic translation initiation factor 4E 1700 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167359&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536086 312321209 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311013 OC(=O)c1cc(ccc1-c1ccccc1C#N)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H12Cl2N2O2S/c24-19-8-6-13(10-20(19)25)21-12-30-22(27-21)14-5-7-17(18(9-14)23(28)29)16-4-2-1-3-15(16)11-26/h1-10,12H,(H,28,29) KURYFNRDENLQDL-UHFFFAOYSA-N 60449 BDBM167360::US9073881, 112 Eukaryotic translation initiation factor 4E 30000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60449&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679855 313084633 ZINC03256263 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311014 OC(=O)c1cc(ccc1-c1ccccc1C#N)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H12Cl2N2O2S/c24-19-8-6-13(10-20(19)25)21-12-30-22(27-21)14-5-7-17(18(9-14)23(28)29)16-4-2-1-3-15(16)11-26/h1-10,12H,(H,28,29) KURYFNRDENLQDL-UHFFFAOYSA-N 60449 BDBM167360::US9073881, 112 Eukaryotic translation initiation factor 4E 30000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60449&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679855 313084633 ZINC03256263 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311015 OC(=O)c1cc(ccc1-c1ccc(C#N)c(Cl)c1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H11Cl3N2O2S/c24-18-6-4-13(9-20(18)26)21-11-31-22(28-21)14-3-5-16(17(7-14)23(29)30)12-1-2-15(10-27)19(25)8-12/h1-9,11H,(H,29,30) JUHXMUXDKJZLTR-UHFFFAOYSA-N 167362 US9073881, 114 Eukaryotic translation initiation factor 4E 1700 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167362&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679856 312321211 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311016 OC(=O)c1cc(ccc1-c1ccc(Cl)c(c1)C#N)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H11Cl3N2O2S/c24-18-5-2-12(7-15(18)10-27)16-4-1-14(8-17(16)23(29)30)22-28-21(11-31-22)13-3-6-19(25)20(26)9-13/h1-9,11H,(H,29,30) PMKCDYBKEUWORJ-UHFFFAOYSA-N 167363 US9073881, 115 Eukaryotic translation initiation factor 4E 1900 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167363&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679857 312321212 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311017 CC(=O)c1cccc(c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C24H15Cl2NO3S/c1-13(28)14-3-2-4-15(9-14)18-7-5-17(10-19(18)24(29)30)23-27-22(12-31-23)16-6-8-20(25)21(26)11-16/h2-12H,1H3,(H,29,30) ZSOIGTJLJKTWBD-UHFFFAOYSA-N 167364 US9073881, 116 Eukaryotic translation initiation factor 4E 7700 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167364&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679858 312321213 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311018 CC(=O)c1ccccc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C24H15Cl2NO3S/c1-13(28)16-4-2-3-5-17(16)18-8-6-15(10-19(18)24(29)30)23-27-22(12-31-23)14-7-9-20(25)21(26)11-14/h2-12H,1H3,(H,29,30) LEMBWUYOQYMPCH-UHFFFAOYSA-N 167365 US9073881, 117 Eukaryotic translation initiation factor 4E 7700 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167365&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679859 312321214 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311019 CC(=O)c1ccc(Cl)c(c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C24H14Cl3NO3S/c1-12(29)13-3-6-19(25)17(8-13)16-5-2-15(9-18(16)24(30)31)23-28-22(11-32-23)14-4-7-20(26)21(27)10-14/h2-11H,1H3,(H,30,31) ALYWSCYOOKBUAR-UHFFFAOYSA-N 167366 US9073881, 118 Eukaryotic translation initiation factor 4E 1500 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167366&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679860 312321215 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311020 CC(=O)c1sccc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H13Cl2NO3S2/c1-11(26)20-15(6-7-29-20)14-4-2-13(8-16(14)22(27)28)21-25-19(10-30-21)12-3-5-17(23)18(24)9-12/h2-10H,1H3,(H,27,28) DEEWNVHOLQJZLX-UHFFFAOYSA-N 167367 US9073881, 119 Eukaryotic translation initiation factor 4E 9600 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167367&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679861 312321216 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311021 CC(=O)c1ccc(cc1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C24H15Cl2NO3S/c1-13(28)14-2-4-15(5-3-14)18-8-6-17(10-19(18)24(29)30)23-27-22(12-31-23)16-7-9-20(25)21(26)11-16/h2-12H,1H3,(H,29,30) MDWIREWIJKUERZ-UHFFFAOYSA-N 167368 US9073881, 120 Eukaryotic translation initiation factor 4E 3800 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167368&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679862 312321217 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311022 OC(=O)c1ccc(c(F)c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H12Cl2FNO4S/c24-17-6-3-11(8-18(17)25)20-10-32-21(27-20)12-1-4-14(16(7-12)23(30)31)15-5-2-13(22(28)29)9-19(15)26/h1-10H,(H,28,29)(H,30,31) XOYQLXAWKYMXJN-UHFFFAOYSA-N 167369 US9073881, 121 Eukaryotic translation initiation factor 4E 6100 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167369&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71537194 312321218 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311023 Cc1ccc(C=O)c(c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C24H15Cl2NO3S/c1-13-2-3-16(11-28)18(8-13)17-6-4-15(9-19(17)24(29)30)23-27-22(12-31-23)14-5-7-20(25)21(26)10-14/h2-12H,1H3,(H,29,30) JIQZXKSUNRQWSD-UHFFFAOYSA-N 167370 US9073881, 122 Eukaryotic translation initiation factor 4E 5100 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167370&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679863 312321219 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311024 OC(=O)c1cc(ccc1-c1ccccc1C=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H13Cl2NO3S/c24-19-8-6-13(10-20(19)25)21-12-30-22(26-21)14-5-7-17(18(9-14)23(28)29)16-4-2-1-3-15(16)11-27/h1-12H,(H,28,29) KPFMXOKIMJASAI-UHFFFAOYSA-N 167371 US9073881, 123 Eukaryotic translation initiation factor 4E 5500 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167371&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679864 312321220 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311025 OC(=O)c1cc(ccc1-c1ccc(F)cc1C(F)(F)F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H11Cl2F4NO2S/c24-18-6-2-11(8-19(18)25)20-10-33-21(30-20)12-1-4-14(16(7-12)22(31)32)15-5-3-13(26)9-17(15)23(27,28)29/h1-10H,(H,31,32) ITPKJXMHSQJVGR-UHFFFAOYSA-N 167372 US9073881, 124 Eukaryotic translation initiation factor 4E 800 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167372&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679865 312321221 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311026 OC(=O)c1cc(ccc1-c1ccc(cc1C(F)(F)F)C(F)(F)F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C24H11Cl2F6NO2S/c25-18-6-2-11(8-19(18)26)20-10-36-21(33-20)12-1-4-14(16(7-12)22(34)35)15-5-3-13(23(27,28)29)9-17(15)24(30,31)32/h1-10H,(H,34,35) YBDBKJYSRUZYMA-UHFFFAOYSA-N 167373 US9073881, 125 Eukaryotic translation initiation factor 4E 3000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167373&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679866 312321222 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311027 OC(=O)c1cc(ccc1-c1cccc(c1Cl)C(F)(F)F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H11Cl3F3NO2S/c24-17-7-5-11(9-18(17)25)19-10-33-21(30-19)12-4-6-13(15(8-12)22(31)32)14-2-1-3-16(20(14)26)23(27,28)29/h1-10H,(H,31,32) CMIUAHZLPNNUFM-UHFFFAOYSA-N 167374 US9073881, 126 Eukaryotic translation initiation factor 4E 2800 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167374&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679867 312321223 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311028 OC(=O)c1cc(ccc1-c1ccc(cc1Cl)C(F)(F)F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H11Cl3F3NO2S/c24-17-6-2-11(8-19(17)26)20-10-33-21(30-20)12-1-4-14(16(7-12)22(31)32)15-5-3-13(9-18(15)25)23(27,28)29/h1-10H,(H,31,32) SDNVBLSBJDSFCC-UHFFFAOYSA-N 167375 US9073881, 127 Eukaryotic translation initiation factor 4E 1600 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167375&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679868 312321224 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311029 OC(=O)c1cc(ccc1-c1cc(ccc1Cl)C(F)(F)F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H11Cl3F3NO2S/c24-17-6-3-13(23(27,28)29)9-15(17)14-4-1-12(7-16(14)22(31)32)21-30-20(10-33-21)11-2-5-18(25)19(26)8-11/h1-10H,(H,31,32) QXUIGTNWLMURDI-UHFFFAOYSA-N 167376 US9073881, 128 Eukaryotic translation initiation factor 4E 1100 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167376&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679869 312321225 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311030 OC(=O)c1cc(ccc1-c1ccc(F)cc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H12Cl2FNO2S/c23-18-8-4-13(10-19(18)24)20-11-29-21(26-20)14-3-7-16(17(9-14)22(27)28)12-1-5-15(25)6-2-12/h1-11H,(H,27,28) WHSDDFWCPFDJKS-UHFFFAOYSA-N 167377 US9073881, 129 Eukaryotic translation initiation factor 4E 2600 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167377&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679870 312321226 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311031 OC(=O)c1cc(ccc1-c1cc(F)ccc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H11Cl3FNO2S/c23-17-6-3-13(26)9-15(17)14-4-1-12(7-16(14)22(28)29)21-27-20(10-30-21)11-2-5-18(24)19(25)8-11/h1-10H,(H,28,29) OTBARWSRKAJNBL-UHFFFAOYSA-N 167378 US9073881, 130 Eukaryotic translation initiation factor 4E 11000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167378&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 74221632 312321227 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311032 OC(=O)c1cc(ccc1-c1cc(F)ccc1F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H11Cl2F2NO2S/c23-17-5-2-11(8-18(17)24)20-10-30-21(27-20)12-1-4-14(16(7-12)22(28)29)15-9-13(25)3-6-19(15)26/h1-10H,(H,28,29) MRZIOESUNQQLNQ-UHFFFAOYSA-N 167379 US9073881, 131 Eukaryotic translation initiation factor 4E 1800 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167379&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 71536087 312321228 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311033 OC(=O)c1cc(ccc1-c1ccc(F)cc1F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H11Cl2F2NO2S/c23-17-6-2-11(8-18(17)24)20-10-30-21(27-20)12-1-4-14(16(7-12)22(28)29)15-5-3-13(25)9-19(15)26/h1-10H,(H,28,29) NMULQQZLWBBIMA-UHFFFAOYSA-N 167380 US9073881, 132 Eukaryotic translation initiation factor 4E 5600 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167380&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679871 312321229 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311034 OC(=O)c1cc(ccc1-c1cc(F)cc(F)c1F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H10Cl2F3NO2S/c23-16-4-2-10(6-17(16)24)19-9-31-21(28-19)11-1-3-13(15(5-11)22(29)30)14-7-12(25)8-18(26)20(14)27/h1-9H,(H,29,30) ZJYAXTXPTCUTJF-UHFFFAOYSA-N 167381 US9073881, 133 Eukaryotic translation initiation factor 4E 1600 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167381&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679872 312321230 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311035 OC(=O)c1cc(ccc1-c1ccc(F)cc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H11Cl3FNO2S/c23-17-6-2-11(8-19(17)25)20-10-30-21(27-20)12-1-4-14(16(7-12)22(28)29)15-5-3-13(26)9-18(15)24/h1-10H,(H,28,29) PXFXAYPSAJASMZ-UHFFFAOYSA-N 167382 US9073881, 134 Eukaryotic translation initiation factor 4E 1400 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167382&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679873 312321231 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311036 OC(=O)c1cc(ccc1-c1ccc(Cl)cc1F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H11Cl3FNO2S/c23-13-3-5-15(19(26)9-13)14-4-1-12(7-16(14)22(28)29)21-27-20(10-30-21)11-2-6-17(24)18(25)8-11/h1-10H,(H,28,29) HZEUKUCIXRKKKY-UHFFFAOYSA-N 167383 US9073881, 135 Eukaryotic translation initiation factor 4E 55000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167383&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679874 312321232 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311037 OC(=O)c1cc(ccc1-c1c(F)cccc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H11Cl3FNO2S/c23-15-7-5-11(9-17(15)25)19-10-30-21(27-19)12-4-6-13(14(8-12)22(28)29)20-16(24)2-1-3-18(20)26/h1-10H,(H,28,29) IJOFTDWIDOZHHD-UHFFFAOYSA-N 167384 US9073881, 136 Eukaryotic translation initiation factor 4E 11000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167384&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679875 312321233 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311038 OC(=O)c1cc(ccc1-c1ccccc1F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H12Cl2FNO2S/c23-17-8-6-12(10-18(17)24)20-11-29-21(26-20)13-5-7-14(16(9-13)22(27)28)15-3-1-2-4-19(15)25/h1-11H,(H,27,28) WMEWJPFIORXEDZ-UHFFFAOYSA-N 167385 US9073881, 137 Eukaryotic translation initiation factor 4E 3600 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167385&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679876 312321234 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311039 OC(=O)c1cc(ccc1-c1cccc(F)c1F)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H11Cl2F2NO2S/c23-16-7-5-11(9-17(16)24)19-10-30-21(27-19)12-4-6-13(15(8-12)22(28)29)14-2-1-3-18(25)20(14)26/h1-10H,(H,28,29) VDMNHODFMUSJPJ-UHFFFAOYSA-N 167386 US9073881, 138 Eukaryotic translation initiation factor 4E 1900 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167386&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679877 312321235 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311040 Cc1ccc(F)c(c1Cl)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H13Cl3FNO2S/c1-11-2-7-18(27)20(21(11)26)14-5-3-13(8-15(14)23(29)30)22-28-19(10-31-22)12-4-6-16(24)17(25)9-12/h2-10H,1H3,(H,29,30) JGEUQPYCOADFCP-UHFFFAOYSA-N 167387 US9073881, 139 Eukaryotic translation initiation factor 4E 1600 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167387&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 89454643 312321236 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311041 Cc1ccc(Cl)c(c1F)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H13Cl3FNO2S/c1-11-2-6-17(25)20(21(11)27)14-5-3-13(8-15(14)23(29)30)22-28-19(10-31-22)12-4-7-16(24)18(26)9-12/h2-10H,1H3,(H,29,30) ZNMDDOAYHHCMLC-UHFFFAOYSA-N 167388 US9073881, 140 Eukaryotic translation initiation factor 4E 700 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167388&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679878 312321237 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311042 OC(=O)c1cc(ccc1-c1ccccc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H13Cl2NO2S/c23-18-9-7-14(11-19(18)24)20-12-28-21(25-20)15-6-8-16(17(10-15)22(26)27)13-4-2-1-3-5-13/h1-12H,(H,26,27) YJBVHNLHUDBXPO-UHFFFAOYSA-N 60447 US9073881, 151 Eukaryotic translation initiation factor 4E 5900 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60447&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679888 313084632 ZINC00423337 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311043 Cc1cscc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C21H13Cl2NO2S2/c1-11-8-27-9-16(11)14-4-2-13(6-15(14)21(25)26)20-24-19(10-28-20)12-3-5-17(22)18(23)7-12/h2-10H,1H3,(H,25,26) MAGIIJQHXAQHJV-UHFFFAOYSA-N 167390 US9073881, 142 Eukaryotic translation initiation factor 4E 4200 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167390&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679880 312321238 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311044 Cc1ccc(c(Cl)c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H14Cl3NO2S/c1-12-2-5-16(19(25)8-12)15-6-3-14(9-17(15)23(28)29)22-27-21(11-30-22)13-4-7-18(24)20(26)10-13/h2-11H,1H3,(H,28,29) SCCIWTHUTPMMCT-UHFFFAOYSA-N 167391 US9073881, 143 Eukaryotic translation initiation factor 4E 11000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167391&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 89454782 312321239 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311045 Cc1ccc(Cl)c(c1)-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H14Cl3NO2S/c1-12-2-6-18(24)16(8-12)15-5-3-14(9-17(15)23(28)29)22-27-21(11-30-22)13-4-7-19(25)20(26)10-13/h2-11H,1H3,(H,28,29) BUGBQHNGQDFEQU-UHFFFAOYSA-N 167392 US9073881, 144 Eukaryotic translation initiation factor 4E 1100 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167392&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679881 312321240 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311046 OC(=O)c1cc(ccc1-c1ccsc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C20H10Cl3NO2S2/c21-15-4-2-10(8-16(15)22)17-9-28-19(24-17)11-1-3-12(14(7-11)20(25)26)13-5-6-27-18(13)23/h1-9H,(H,25,26) WYYZTMQBMOIARM-UHFFFAOYSA-N 167393 US9073881, 145 Eukaryotic translation initiation factor 4E 2200 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167393&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679882 312321241 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311047 OC(=O)c1cc(ccc1-c1sccc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C20H10Cl3NO2S2/c21-14-4-2-10(8-16(14)23)17-9-28-19(24-17)11-1-3-12(13(7-11)20(25)26)18-15(22)5-6-27-18/h1-9H,(H,25,26) GSMKRMVHCCCSAW-UHFFFAOYSA-N 167394 US9073881, 146 Eukaryotic translation initiation factor 4E 1700 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167394&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679883 312321242 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311048 OC(=O)c1cc(ccc1-c1ccc(Cl)cc1)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H12Cl3NO2S/c23-15-5-1-12(2-6-15)16-7-3-14(9-17(16)22(27)28)21-26-20(11-29-21)13-4-8-18(24)19(25)10-13/h1-11H,(H,27,28) BGRRDGXZQZLLHA-UHFFFAOYSA-N 167395 US9073881, 147 Eukaryotic translation initiation factor 4E 1700 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167395&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679884 312321243 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311049 OC(=O)c1cc(ccc1-c1cc(Cl)ccc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H11Cl4NO2S/c23-13-3-6-17(24)15(9-13)14-4-1-12(7-16(14)22(28)29)21-27-20(10-30-21)11-2-5-18(25)19(26)8-11/h1-10H,(H,28,29) RUGSBEVPRXTXAC-UHFFFAOYSA-N 167396 US9073881, 148 Eukaryotic translation initiation factor 4E 1700 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167396&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679885 312321244 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311050 OC(=O)c1cc(ccc1-c1cc(Cl)cc(Cl)c1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H10Cl5NO2S/c23-12-7-14(20(27)18(26)8-12)13-3-1-11(5-15(13)22(29)30)21-28-19(9-31-21)10-2-4-16(24)17(25)6-10/h1-9H,(H,29,30) UCQQQGBOLDLXEQ-UHFFFAOYSA-N 167397 US9073881, 149 Eukaryotic translation initiation factor 4E >80000 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167397&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679886 312321245 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311051 OC(=O)c1cc(ccc1-c1ccc(Cl)cc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H11Cl4NO2S/c23-13-3-5-15(18(25)9-13)14-4-1-12(7-16(14)22(28)29)21-27-20(10-30-21)11-2-6-17(24)19(26)8-11/h1-10H,(H,28,29) GKCFYOAZRVIVTN-UHFFFAOYSA-N 167398 US9073881, 150 Eukaryotic translation initiation factor 4E 1400 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167398&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679887 312321246 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311052 Cc1ccccc1-c1ccc(cc1C(O)=O)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C23H15Cl2NO2S/c1-13-4-2-3-5-16(13)17-8-6-15(10-18(17)23(27)28)22-26-21(12-29-22)14-7-9-19(24)20(25)11-14/h2-12H,1H3,(H,27,28) PMDHIJVHWJCPCS-UHFFFAOYSA-N 60446 US9073881, 141 Eukaryotic translation initiation factor 4E 5900 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60446&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679879 313084631 ZINC15932142 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311053 OC(=O)c1cc(ccc1-c1cccc(Cl)c1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H11Cl4NO2S/c23-16-7-5-11(9-18(16)25)19-10-30-21(27-19)12-4-6-13(15(8-12)22(28)29)14-2-1-3-17(24)20(14)26/h1-10H,(H,28,29) XGCYYHZTKSEMEH-UHFFFAOYSA-N 167400 US9073881, 152 Eukaryotic translation initiation factor 4E 2100 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167400&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679889 312321247 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 311054 OC(=O)c1cc(ccc1-c1ccccc1Cl)-c1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C22H12Cl3NO2S/c23-17-4-2-1-3-15(17)14-7-5-13(9-16(14)22(27)28)21-26-20(11-29-21)12-6-8-18(24)19(25)10-12/h1-11H,(H,27,28) MFLWPQJUYRVEEF-UHFFFAOYSA-N 167401 US9073881, 153 Eukaryotic translation initiation factor 4E 2200 7 US Patent 10.7270/Q2513X0T aid1801395 US9073881 Gillespie, P Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167401&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 86679890 312321248 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103767 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(CSc3cc(Cl)c(Cl)cc-23)s1 InChI=1S/C19H12Cl2N4O4S2/c20-11-6-10-15(7-12(11)21)30-8-16-17(10)22-19(31-16)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13- PVJPULCRKCDKPZ-QRVIBDJDSA-N 50018902 CHEMBL3287115 Eukaryotic translation initiation factor 4E 14000 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018902&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 88568650 103929955 CHEMBL3287115 ZINC96179062 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103769 COc1cc2CCc3sc(N\N=C(/Cc4ccccc4[N+]([O-])=O)C(O)=O)nc3-c2cc1OC InChI=1S/C22H20N4O6S/c1-31-17-10-12-7-8-19-20(14(12)11-18(17)32-2)23-22(33-19)25-24-15(21(27)28)9-13-5-3-4-6-16(13)26(29)30/h3-6,10-11H,7-9H2,1-2H3,(H,23,25)(H,27,28)/b24-15+ DOCIYYMWTKZCCJ-BUVRLJJBSA-N 50018903 CHEMBL3287126 Eukaryotic translation initiation factor 4E 10500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018903&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 90644210 103929956 CHEMBL3287126 ZINC95611956 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103773 COc1cc2OCc3sc(N\N=C(/Cc4ccccc4[N+]([O-])=O)C(O)=O)nc3-c2cc1OC InChI=1S/C21H18N4O7S/c1-30-16-8-12-15(9-17(16)31-2)32-10-18-19(12)22-21(33-18)24-23-13(20(26)27)7-11-5-3-4-6-14(11)25(28)29/h3-6,8-9H,7,10H2,1-2H3,(H,22,24)(H,26,27)/b23-13+ OWKOTEFVGVORRT-YDZHTSKRSA-N 50018904 CHEMBL3287130 Eukaryotic translation initiation factor 4E 10500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018904&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 90644211 103929957 CHEMBL3287130 ZINC95611975 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103774 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(CSc3c(Cl)c(Cl)ccc-23)s1 InChI=1S/C19H12Cl2N4O4S2/c20-11-6-5-10-16-14(8-30-17(10)15(11)21)31-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12- WZCAXBBILBSNCM-FMCGGJTJSA-N 50018906 CHEMBL3287117 Eukaryotic translation initiation factor 4E 11500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018906&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 88568652 103929959 CHEMBL3287117 ZINC34802507 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103775 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(COc3c(Cl)c(Cl)ccc-23)s1 InChI=1S/C19H12Cl2N4O5S/c20-11-6-5-10-16-14(8-30-17(10)15(11)21)31-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12- KBZVCOIIBBVMMZ-FMCGGJTJSA-N 50018907 CHEMBL3287111 Eukaryotic translation initiation factor 4E 15500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018907&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 87278547 103929960 CHEMBL3287111 ZINC29243074 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103776 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(CSc3cc(Cl)c(Cl)cc-23)s1 InChI=1S/C19H12Cl2N4O4S2/c20-11-6-10-15(7-12(11)21)30-8-16-17(10)22-19(31-16)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13+ PVJPULCRKCDKPZ-YDZHTSKRSA-N 50018908 CHEMBL3287114 Eukaryotic translation initiation factor 4E 15500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018908&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 90644212 103929961 CHEMBL3287114 ZINC29306683 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103777 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(COc3cc(Cl)c(Cl)cc-23)s1 InChI=1S/C19H12Cl2N4O5S/c20-11-6-10-15(7-12(11)21)30-8-16-17(10)22-19(31-16)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13+ KOZBTIDUIKQFSM-YDZHTSKRSA-N 50018909 CHEMBL3287112 Eukaryotic translation initiation factor 4E 18500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018909&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 88568626 103929962 CHEMBL3287112 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103780 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(CCc3cc(Cl)c(Cl)cc-23)s1 InChI=1S/C20H14Cl2N4O4S/c21-13-7-10-5-6-17-18(12(10)9-14(13)22)23-20(31-17)25-24-15(19(27)28)8-11-3-1-2-4-16(11)26(29)30/h1-4,7,9H,5-6,8H2,(H,23,25)(H,27,28)/b24-15+ BEGIYCBXMJSJFE-BUVRLJJBSA-N 50018910 CHEMBL3287106 Eukaryotic translation initiation factor 4E 21500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018910&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 88568595 103929963 CHEMBL3287106 ZINC95613320 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103781 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(COc3c(Cl)c(Cl)ccc-23)s1 InChI=1S/C19H12Cl2N4O5S/c20-11-6-5-10-16-14(8-30-17(10)15(11)21)31-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12+ KBZVCOIIBBVMMZ-FSJBWODESA-N 50018911 CHEMBL3287110 Eukaryotic translation initiation factor 4E 25000 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018911&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 88568566 103929964 CHEMBL3287110 ZINC95543383 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103783 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(COc3cc(Cl)c(Cl)cc-23)s1 InChI=1S/C19H12Cl2N4O5S/c20-11-6-10-15(7-12(11)21)30-8-16-17(10)22-19(31-16)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13- KOZBTIDUIKQFSM-QRVIBDJDSA-N 50018913 CHEMBL3287113 Eukaryotic translation initiation factor 4E 27000 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018913&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 87278522 103929966 CHEMBL3287113 ZINC36350265 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103786 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(CSc3c(Cl)c(Cl)ccc-23)s1 InChI=1S/C19H12Cl2N4O4S2/c20-11-6-5-10-16-14(8-30-17(10)15(11)21)31-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12+ WZCAXBBILBSNCM-FSJBWODESA-N 50018916 CHEMBL3287116 Eukaryotic translation initiation factor 4E 28000 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018916&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 88568651 103929969 CHEMBL3287116 ZINC05499278 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103788 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(C[S+]([O-])c3cc(Cl)c(Cl)cc-23)s1 InChI=1S/C19H12Cl2N4O5S2/c20-11-6-10-16(7-12(11)21)32(30)8-15-17(10)22-19(31-15)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13- GOOZJSWTRQFCSX-QRVIBDJDSA-N 50018917 CHEMBL3287119 Eukaryotic translation initiation factor 4E 30000 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018917&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 90644213 103929970 CHEMBL3287119 ZINC40723395 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103791 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(CCc3c(Cl)c(Cl)ccc-23)s1 InChI=1S/C20H14Cl2N4O4S/c21-13-7-5-12-11(17(13)22)6-8-16-18(12)23-20(31-16)25-24-14(19(27)28)9-10-3-1-2-4-15(10)26(29)30/h1-5,7H,6,8-9H2,(H,23,25)(H,27,28)/b24-14+ XCEJCUSUGFIQIE-ZVHZXABRSA-N 50018918 CHEMBL3287108 Eukaryotic translation initiation factor 4E 32000 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018918&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 88568567 242041993 CHEMBL3287108 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103793 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14- KFRKRECSIYXARE-HMAPJEAMSA-N 50018919 CHEMBL254578 Eukaryotic translation initiation factor 4E 43500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018919&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 6911989 242041994 CHEMBL254578 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103794 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(C[S+]([O-])c3cc(Cl)c(Cl)cc-23)s1 InChI=1S/C19H12Cl2N4O5S2/c20-11-6-10-16(7-12(11)21)32(30)8-15-17(10)22-19(31-15)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13+ GOOZJSWTRQFCSX-YDZHTSKRSA-N 50018920 CHEMBL3287118 Eukaryotic translation initiation factor 4E 30500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018920&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 90644214 242041995 CHEMBL3287118 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103795 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(C[S+]([O-])c3c(Cl)c(Cl)ccc-23)s1 InChI=1S/C19H12Cl2N4O5S2/c20-11-6-5-10-16-14(8-32(30)17(10)15(11)21)31-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12- UTNOIQNSFCVTAB-FMCGGJTJSA-N 50018921 CHEMBL3287121 Eukaryotic translation initiation factor 4E 32500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018921&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 90644215 242041996 CHEMBL3287121 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103796 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(CCc3c(Cl)c(Cl)ccc-23)s1 InChI=1S/C20H14Cl2N4O4S/c21-13-7-5-12-11(17(13)22)6-8-16-18(12)23-20(31-16)25-24-14(19(27)28)9-10-3-1-2-4-15(10)26(29)30/h1-5,7H,6,8-9H2,(H,23,25)(H,27,28)/b24-14- XCEJCUSUGFIQIE-OYKKKHCWSA-N 50018922 CHEMBL3287109 Eukaryotic translation initiation factor 4E 43500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018922&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 87278583 242041997 CHEMBL3287109 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103799 COc1cc2CCc3sc(N\N=C(\Cc4ccccc4[N+]([O-])=O)C(O)=O)nc3-c2cc1OC InChI=1S/C22H20N4O6S/c1-31-17-10-12-7-8-19-20(14(12)11-18(17)32-2)23-22(33-19)25-24-15(21(27)28)9-13-5-3-4-6-16(13)26(29)30/h3-6,10-11H,7-9H2,1-2H3,(H,23,25)(H,27,28)/b24-15- DOCIYYMWTKZCCJ-IWIPYMOSSA-N 50018923 CHEMBL3287127 Eukaryotic translation initiation factor 4E 45000 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018923&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 87278578 242041998 CHEMBL3287127 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103801 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(CS(=O)(=O)c3cc(Cl)c(Cl)cc-23)s1 InChI=1S/C19H12Cl2N4O6S2/c20-11-6-10-16(7-12(11)21)33(30,31)8-15-17(10)22-19(32-15)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13+ WXEUUGWVBOMIAM-YDZHTSKRSA-N 50018924 CHEMBL3287124 Eukaryotic translation initiation factor 4E 49000 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018924&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 90644216 242041999 CHEMBL3287124 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103805 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(CS(=O)(=O)c3cc(Cl)c(Cl)cc-23)s1 InChI=1S/C19H12Cl2N4O6S2/c20-11-6-10-16(7-12(11)21)33(30,31)8-15-17(10)22-19(32-15)24-23-13(18(26)27)5-9-3-1-2-4-14(9)25(28)29/h1-4,6-7H,5,8H2,(H,22,24)(H,26,27)/b23-13- WXEUUGWVBOMIAM-QRVIBDJDSA-N 50018925 CHEMBL3287125 Eukaryotic translation initiation factor 4E 49000 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018925&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 90644217 242042000 CHEMBL3287125 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103806 COc1ccc2-c3nc(N\N=C(/Cc4ccccc4[N+]([O-])=O)C(O)=O)sc3COc2c1OC InChI=1S/C21H18N4O7S/c1-30-15-8-7-12-17-16(10-32-18(12)19(15)31-2)33-21(22-17)24-23-13(20(26)27)9-11-5-3-4-6-14(11)25(28)29/h3-8H,9-10H2,1-2H3,(H,22,24)(H,26,27)/b23-13+ LRMGOHKZJYHHKE-YDZHTSKRSA-N 50018926 CHEMBL3287128 Eukaryotic translation initiation factor 4E 16500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018926&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 90644218 242042001 CHEMBL3287128 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103807 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(CCc3cc(Cl)c(Cl)cc-23)s1 InChI=1S/C20H14Cl2N4O4S/c21-13-7-10-5-6-17-18(12(10)9-14(13)22)23-20(31-17)25-24-15(19(27)28)8-11-3-1-2-4-16(11)26(29)30/h1-4,7,9H,5-6,8H2,(H,23,25)(H,27,28)/b24-15- BEGIYCBXMJSJFE-IWIPYMOSSA-N 50018927 CHEMBL3287107 Eukaryotic translation initiation factor 4E 34000 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018927&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 87278548 242042002 CHEMBL3287107 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103810 COc1cc2OCc3sc(N\N=C(\Cc4ccccc4[N+]([O-])=O)C(O)=O)nc3-c2cc1OC InChI=1S/C21H18N4O7S/c1-30-16-8-12-15(9-17(16)31-2)32-10-18-19(12)22-21(33-18)24-23-13(20(26)27)7-11-5-3-4-6-14(11)25(28)29/h3-6,8-9H,7,10H2,1-2H3,(H,22,24)(H,26,27)/b23-13- OWKOTEFVGVORRT-QRVIBDJDSA-N 50018928 CHEMBL3287131 Eukaryotic translation initiation factor 4E 51500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018928&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 90644219 242042003 CHEMBL3287131 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103811 COc1ccc2-c3nc(N\N=C(\Cc4ccccc4[N+]([O-])=O)C(O)=O)sc3COc2c1OC InChI=1S/C21H18N4O7S/c1-30-15-8-7-12-17-16(10-32-18(12)19(15)31-2)33-21(22-17)24-23-13(20(26)27)9-11-5-3-4-6-14(11)25(28)29/h3-8H,9-10H2,1-2H3,(H,22,24)(H,26,27)/b23-13- LRMGOHKZJYHHKE-QRVIBDJDSA-N 50018934 CHEMBL3287129 Eukaryotic translation initiation factor 4E 55500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018934&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 90644220 103929976 CHEMBL3287129 ZINC29399561 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103812 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc-2c(CS(=O)(=O)c3c(Cl)c(Cl)ccc-23)s1 InChI=1S/C19H12Cl2N4O6S2/c20-11-6-5-10-16-14(8-33(30,31)17(10)15(11)21)32-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12- XFHCZTXGFWNUAY-FMCGGJTJSA-N 50018935 CHEMBL3287123 Eukaryotic translation initiation factor 4E 39000 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018935&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 90644221 103929977 CHEMBL3287123 ZINC29397629 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103813 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(CS(=O)(=O)c3c(Cl)c(Cl)ccc-23)s1 InChI=1S/C19H12Cl2N4O6S2/c20-11-6-5-10-16-14(8-33(30,31)17(10)15(11)21)32-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12+ XFHCZTXGFWNUAY-FSJBWODESA-N 50018936 CHEMBL3287122 Eukaryotic translation initiation factor 4E 40500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018936&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 90644222 103929978 CHEMBL3287122 ZINC49637800 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50103814 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N\Nc1nc-2c(C[S+]([O-])c3c(Cl)c(Cl)ccc-23)s1 InChI=1S/C19H12Cl2N4O5S2/c20-11-6-5-10-16-14(8-32(30)17(10)15(11)21)31-19(22-16)24-23-12(18(26)27)7-9-3-1-2-4-13(9)25(28)29/h1-6H,7-8H2,(H,22,24)(H,26,27)/b23-12+ UTNOIQNSFCVTAB-FSJBWODESA-N 50018937 CHEMBL3287120 Eukaryotic translation initiation factor 4E 48500 ChEMBL 10.1021/jm401733v 10.7270/Q2251KR7 24827861 Mahalingam, P; Takrouri, K; Chen, T; Sahoo, R; Papadopoulos, E; Chen, L; Wagner, G; Aktas, BH; Halperin, JA; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018937&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 90644223 103929979 CHEMBL3287120 ZINC49637724 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50265968 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14- KFRKRECSIYXARE-HMAPJEAMSA-N 50018919 CHEMBL254578 Eukaryotic translation initiation factor 4E 8740000 ChEMBL 10.1016/j.ejmech.2014.03.034 10.7270/Q2Z89F19 24675136 Takrouri, K; Chen, T; Papadopoulos, E; Sahoo, R; Kabha, E; Chen, H; Cantel, S; Wagner, G; Halperin, JA; Aktas, BH; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50018919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50018919&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 6911989 242041994 CHEMBL254578 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50265969 Nc1ccc(C\C(=N\Nc2nc(cs2)-c2ccc(Cl)c(Cl)c2)C(O)=O)cc1[N+]([O-])=O InChI=1S/C18H13Cl2N5O4S/c19-11-3-2-10(7-12(11)20)15-8-30-18(22-15)24-23-14(17(26)27)5-9-1-4-13(21)16(6-9)25(28)29/h1-4,6-8H,5,21H2,(H,22,24)(H,26,27)/b23-14- UDQBWENWZFKAGN-UCQKPKSFSA-N 50044268 CHEMBL3310215 Eukaryotic translation initiation factor 4E 5010000 ChEMBL 10.1016/j.ejmech.2014.03.034 10.7270/Q2Z89F19 24675136 Takrouri, K; Chen, T; Papadopoulos, E; Sahoo, R; Kabha, E; Chen, H; Cantel, S; Wagner, G; Halperin, JA; Aktas, BH; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50044268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50044268&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 118706355 313068163 CHEMBL3310215 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50265970 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc(cs1)-c1ccc(O)cc1 InChI=1S/C18H14N4O5S/c23-13-7-5-11(6-8-13)15-10-28-18(19-15)21-20-14(17(24)25)9-12-3-1-2-4-16(12)22(26)27/h1-8,10,23H,9H2,(H,19,21)(H,24,25)/b20-14- RIXSYGNFNQCJLM-ZHZULCJRSA-N 50044269 CHEMBL3310347 Eukaryotic translation initiation factor 4E 36600000 ChEMBL 10.1016/j.ejmech.2014.03.034 10.7270/Q2Z89F19 24675136 Takrouri, K; Chen, T; Papadopoulos, E; Sahoo, R; Kabha, E; Chen, H; Cantel, S; Wagner, G; Halperin, JA; Aktas, BH; Chorev, M Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50044269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50044269&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 118706440 313068164 CHEMBL3310347 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50613925 CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1O InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 36609 Rapamycin C-7, analog 4::SIROLIMUS::US11603377, Compound Ramycin Eukaryotic translation initiation factor 4E 0.5 ChEMBL 10.1016/j.bmc.2010.04.005 10.7270/Q2KS6RTZ 20427189 Sadovski, O; Jaikaran, AS; Samanta, S; Fabian, MR; Dowling, RJ; Sonenberg, N; Woolley, GA University of Toronto http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36609&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search RAP 1Z58,5FLC,1C9H,4DRJ,4DRH,4DRI,5GPG,1PBK,7F2J,1FAP,4QT3,4QT2,2VCD,2DG4,2DG3,2DG9,5HKG,1FKL,1FKB,3KZ7,6M4W,6M4V,6M4U 5284616 118043176 9168 C07909 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825835 CC(C)O[C@H]1[C@@H](COP([O-])=O)O[C@H](C1OC(C)C)n1c[nH+]c2c1nc(N)[nH]c2=O InChI=1S/C16H26N5O7P/c1-7(2)26-11-9(5-25-29(23)24)28-15(12(11)27-8(3)4)21-6-18-10-13(21)19-16(17)20-14(10)22/h6-9,11-12,15,29H,5H2,1-4H3,(H,23,24)(H3,17,19,20,22)/t9-,11+,12?,15-/m1/s1 ITQYSMVMPNBHRU-WABSSEDKSA-N 50165117 2-amino-6-hydroxy-9-[(2R,4S,5R)-5-[(phosphinatooxy)methyl]-3,4-bis(propan-2-yloxy)oxolan-2-yl]-9H-purin-7-ium; triethylazanium Eukaryotic translation initiation factor 4E 180000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165117&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 44401796 104050704 C03498 ZINC28523386 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825836 Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1C[C@@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)O1 InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/p-4/t4-,5-,6-/m1/s1 HAAZLUGHYHWQIW-HSUXUTPPSA-J 50165116 CHEMBL194007::tetrasodium ({[(2R,3R,5R)-5-(2-amino-6-hydroxy-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl phosphonato}oxy)(phosphonatooxy)phosphinate Eukaryotic translation initiation factor 4E >400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165116&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 59524703 104050703 CHEMBL194007 C03517 ZINC13546384 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825837 CC(C)O[C@H]1[C@@H](CO)O[C@H](C1OC(C)C)n1c[n+](Cc2ccccc2)c2c1nc(N)[nH]c2=O InChI=1S/C23H31N5O5/c1-13(2)31-18-16(11-29)33-22(19(18)32-14(3)4)28-12-27(10-15-8-6-5-7-9-15)17-20(28)25-23(24)26-21(17)30/h5-9,12-14,16,18-19,22,29H,10-11H2,1-4H3,(H2-,24,25,26,30)/p+1/t16-,18+,19?,22-/m1/s1 CSGJJNJPLMSZSR-GNIVAGDMSA-O 50165118 2-Amino-7-benzyl-9-((2R,4S,5R)-5-hydroxymethyl-3,4-diisopropoxy-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-7-ium::CHEMBL382100 Eukaryotic translation initiation factor 4E >400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165118&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 44401909 104050705 CHEMBL382100 ZINC28524379 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825838 CC(C)O[C@H]1[C@@H](CO)O[C@H](C1OC(C)C)n1c[n+](C)c2c1nc(N)[nH]c2=O InChI=1S/C17H27N5O5/c1-8(2)25-12-10(6-23)27-16(13(12)26-9(3)4)22-7-21(5)11-14(22)19-17(18)20-15(11)24/h7-10,12-13,16,23H,6H2,1-5H3,(H2-,18,19,20,24)/p+1/t10-,12+,13?,16-/m1/s1 BARSWAKIRRUMSK-QEFZCKDJSA-O 50165119 2-Amino-9-((2R,4S,5R)-5-hydroxymethyl-3,4-diisopropoxy-tetrahydro-furan-2-yl)-7-methyl-6-oxo-6,9-dihydro-1H-purin-7-ium::CHEMBL193547 Eukaryotic translation initiation factor 4E >400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165119&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 44401814 104050706 CHEMBL193547 ZINC28523414 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825839 Nc1nc2n(c[n+](Cc3ccccc3)c2c(=O)[nH]1)C1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C17H20N5O8P/c18-17-19-14-11(15(25)20-17)21(6-9-4-2-1-3-5-9)8-22(14)16-13(24)12(23)10(30-16)7-29-31(26,27)28/h1-5,8,10,12-13,16,23-24H,6-7H2,(H4-,18,19,20,25,26,27,28)/p-1/t10-,12-,13-,16?/m1/s1 WMKJRKYLDWLLPS-AARXTDBFSA-M 50370481 CHEMBL611113 Eukaryotic translation initiation factor 4E 220000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370481&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91930055 160849583 CHEMBL611113 ZINC49032481 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825841 CC(C)O[C@H]1[C@@H](COP([O-])(=O)NCCC([O-])=O)O[C@H](C1OC(C)C)n1c[nH+]c2c1nc(N)[nH]c2=O InChI=1S/C19H31N6O9P/c1-9(2)32-14-11(7-31-35(29,30)22-6-5-12(26)27)34-18(15(14)33-10(3)4)25-8-21-13-16(25)23-19(20)24-17(13)28/h8-11,14-15,18H,5-7H2,1-4H3,(H,26,27)(H2,22,29,30)(H3,20,23,24,28)/p-1/t11-,14+,15?,18-/m1/s1 BOGSMJGITWKGPP-NWYBNOCISA-M 50165122 CHEMBL195283::disodium 2-amino-9-[(2R,4S,5R)-5-[({[(2-carboxylatoethyl)amino]phosphinato}oxy)methyl]-3,4-bis(propan-2-yloxy)oxolan-2-yl]-6-hydroxy-9H-purin-7-ium Eukaryotic translation initiation factor 4E 400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165122&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91936724 104050709 CHEMBL195283 ZINC28522703 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825843 CC[n+]1cn(C2O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 InChI=1S/C12H18N5O8P/c1-2-16-4-17(9-6(16)10(20)15-12(13)14-9)11-8(19)7(18)5(25-11)3-24-26(21,22)23/h4-5,7-8,11,18-19H,2-3H2,1H3,(H4-,13,14,15,20,21,22,23)/p-1/t5-,7-,8-,11?/m1/s1 ZWNDOYOXSQFHTA-YNJARDAQSA-M 50370482 CHEMBL610852 Eukaryotic translation initiation factor 4E 100000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370482&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91930056 160849584 CHEMBL610852 ZINC49110353 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825844 CC(C)O[C@H]1[C@@H](CO)O[C@H](C1OC(C)C)n1cnc2c1nc(N)[nH]c2=O InChI=1S/C16H25N5O5/c1-7(2)24-11-9(5-22)26-15(12(11)25-8(3)4)21-6-18-10-13(21)19-16(17)20-14(10)23/h6-9,11-12,15,22H,5H2,1-4H3,(H3,17,19,20,23)/t9-,11+,12?,15-/m1/s1 ZILVDJSDJUEGCF-WABSSEDKSA-N 50165127 2-Amino-9-((2R,4S,5R)-5-hydroxymethyl-3,4-diisopropoxy-tetrahydro-furan-2-yl)-1,9-dihydro-purin-6-one::CHEMBL372079 Eukaryotic translation initiation factor 4E >400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165127&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 44401930 104050714 CHEMBL372079 ZINC28524833 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825845 CN1CN(C2O[C@H](CO)[C@@H](O)[C@H]2O)C2=NC=NC(O)C12 InChI=1S/C11H18N4O5/c1-14-4-15(9-6(14)10(19)13-3-12-9)11-8(18)7(17)5(2-16)20-11/h3,5-8,10-11,16-19H,2,4H2,1H3/t5-,6?,7-,8-,10?,11?/m1/s1 PGGFFMZKRBRMSA-IOMWUIDWSA-N 50370483 CHEMBL607903 Eukaryotic translation initiation factor 4E >400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370483&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91930057 160849585 CHEMBL607903 ZINC49017494 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825847 C[n+]1cn(C2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 InChI=1S/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/p+1/t4-,6-,7-,10?/m1/s1 OGHAROSJZRTIOK-VTHZCTBJSA-O 50370484 CHEMBL611105 Eukaryotic translation initiation factor 4E >400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370484&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 46877327 160849586 CHEMBL611105 ZINC49032119 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825849 CC[n+]1cn([C@@H]2O[C@H](CO)[C@H](OC(C)C)C2OC(C)C)c2nc(N)[nH]c(=O)c12 InChI=1S/C18H29N5O5/c1-6-22-8-23(15-12(22)16(25)21-18(19)20-15)17-14(27-10(4)5)13(26-9(2)3)11(7-24)28-17/h8-11,13-14,17,24H,6-7H2,1-5H3,(H2-,19,20,21,25)/p+1/t11-,13+,14?,17-/m1/s1 FKECPCDTFCIGMF-NUKIEUHSSA-O 50165134 2-Amino-7-ethyl-9-((2R,4S,5R)-5-hydroxymethyl-3,4-diisopropoxy-tetrahydro-furan-2-yl)-6-oxo-6,9-dihydro-1H-purin-7-ium::CHEMBL193326 Eukaryotic translation initiation factor 4E >400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165134&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 44401693 104050721 CHEMBL193326 ZINC28523514 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825851 Cc1ccc(SNc2nc3n(cnc3c(=O)[nH]2)C2O[C@H](CO)[C@@H](O)[C@H]2O)cc1 InChI=1S/C17H19N5O5S/c1-8-2-4-9(5-3-8)28-21-17-19-14-11(15(26)20-17)18-7-22(14)16-13(25)12(24)10(6-23)27-16/h2-5,7,10,12-13,16,23-25H,6H2,1H3,(H2,19,20,21,26)/t10-,12-,13-,16?/m1/s1 GAVXBSHVPZVMHE-AARXTDBFSA-N 50370485 CHEMBL611114 Eukaryotic translation initiation factor 4E >400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370485&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 46877358 160849587 CHEMBL611114 ZINC49792605 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825852 CN(C)c1nc2n(ccc2c(=O)[nH]1)C1O[C@H](CO)[C@@H](O)[C@H]1O InChI=1S/C13H18N4O5/c1-16(2)13-14-10-6(11(21)15-13)3-4-17(10)12-9(20)8(19)7(5-18)22-12/h3-4,7-9,12,18-20H,5H2,1-2H3,(H,14,15,21)/t7-,8-,9-,12?/m1/s1 SNSRRFGLXRUTCB-RNRLFLAJSA-N 50370486 CHEMBL611097 Eukaryotic translation initiation factor 4E >400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370486&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 46877309 160849588 CHEMBL611097 ZINC49031770 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825853 CC(C)O[C@H]1[C@@H](COP([O-])(=O)NC(C([O-])=O)C(=O)c2ccccc2)O[C@H](C1OC(C)C)n1c[nH+]c2c1nc(N)[nH]c2=O InChI=1S/C25H33N6O10P/c1-12(2)39-19-15(10-38-42(36,37)30-16(24(34)35)18(32)14-8-6-5-7-9-14)41-23(20(19)40-13(3)4)31-11-27-17-21(31)28-25(26)29-22(17)33/h5-9,11-13,15-16,19-20,23H,10H2,1-4H3,(H,34,35)(H2,30,36,37)(H3,26,28,29,33)/p-1/t15-,16?,19+,20?,23-/m1/s1 KRYBNXLEOXPKTJ-KPRHEIOISA-M 50165135 CHEMBL193790::disodium 2-amino-9-[(2R,4S,5R)-5-[({[(1-carboxylato-2-oxo-2-phenylethyl)amino]phosphinato}oxy)methyl]-3,4-bis(propan-2-yloxy)oxolan-2-yl]-6-hydroxy-9H-purin-7-ium Eukaryotic translation initiation factor 4E 400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165135&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91936725 104050722 CHEMBL193790 ZINC43482044 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825855 Nc1nc2n(c[n+](Cc3ccccc3)c2c(=O)[nH]1)C1O[C@H](COP([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C17H20N5O7P/c18-17-19-14-11(15(25)20-17)21(6-9-4-2-1-3-5-9)8-22(14)16-13(24)12(23)10(29-16)7-28-30(26)27/h1-5,8,10,12-13,16,23-24,30H,6-7H2,(H3-,18,19,20,25,26,27)/t10-,12-,13-,16?/m1/s1 GRVYMYFXZTVXNB-AARXTDBFSA-N 50370487 CHEMBL609052 Eukaryotic translation initiation factor 4E 200000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370487&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 46876755 160849589 CHEMBL609052 C03498 ZINC49019676 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825856 C[n+]1cn(C2O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/p-3/t4-,6-,7-,10?/m1/s1 DKVRNHPCAOHRSI-VTHZCTBJSA-K 50370488 CHEMBL607618 Eukaryotic translation initiation factor 4E 5000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370488&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91930058 160849590 CHEMBL607618 C03517 ZINC49771876 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825857 CN1CN(C2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=S)c12 InChI=1S/C11H17N5O4S/c1-15-3-16(8-5(15)9(21)14-11(12)13-8)10-7(19)6(18)4(2-17)20-10/h4,6-7,10,17-19H,2-3H2,1H3,(H3,12,13,14,21)/t4-,6-,7-,10?/m1/s1 VAXBEGYAFJOXBG-VTHZCTBJSA-N 50370489 CHEMBL607902 Eukaryotic translation initiation factor 4E >400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370489&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 46876775 160849591 CHEMBL607902 ZINC49792640 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825858 C[n+]1cn(C2O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 InChI=1S/C11H16N5O8P/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(24-10)2-23-25(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H4-,12,13,14,19,20,21,22)/p-1/t4-,6-,7-,10?/m1/s1 AOKQNZVJJXPUQA-VTHZCTBJSA-M 50370490 CHEMBL610599 Eukaryotic translation initiation factor 4E 50000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370490&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91930059 160849592 CHEMBL610599 ZINC49089250 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825859 Nc1nc2n(cnc2c(=O)[nH]1)C1O[C@H](COP([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C10H14N5O7P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(22-9)1-21-23(19)20/h2-3,5-6,9,16-17,23H,1H2,(H,19,20)(H3,11,13,14,18)/p-1/t3-,5-,6-,9?/m1/s1 NKPRSPKWPQPFTK-LZGMGDPASA-M 50370491 CHEMBL611110 Eukaryotic translation initiation factor 4E 130000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370491&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 46877353 160849593 CHEMBL611110 C03498 ZINC49792603 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825860 CC(C)O[C@H]1[C@@H](COP([O-])(=O)NCC([O-])=O)O[C@H](C1OC(C)C)n1c[nH+]c2c1nc(N)[nH]c2=O InChI=1S/C18H29N6O9P/c1-8(2)31-13-10(6-30-34(28,29)21-5-11(25)26)33-17(14(13)32-9(3)4)24-7-20-12-15(24)22-18(19)23-16(12)27/h7-10,13-14,17H,5-6H2,1-4H3,(H,25,26)(H2,21,28,29)(H3,19,22,23,27)/p-1/t10-,13+,14?,17-/m1/s1 PBQOAFVAKVHJKZ-JVDGCLPLSA-M 50165142 CHEMBL194978::disodium 2-amino-9-[(2R,4S,5R)-5-[({[(carboxylatomethyl)amino]phosphinato}oxy)methyl]-3,4-bis(propan-2-yloxy)oxolan-2-yl]-6-hydroxy-9H-purin-7-ium Eukaryotic translation initiation factor 4E >400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165142&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91936727 104050729 CHEMBL194978 ZINC28525489 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825861 Nc1nc2n(c[n+](CC=C)c2c(=O)[nH]1)C1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C13H18N5O8P/c1-2-3-17-5-18(10-7(17)11(21)16-13(14)15-10)12-9(20)8(19)6(26-12)4-25-27(22,23)24/h2,5-6,8-9,12,19-20H,1,3-4H2,(H4-,14,15,16,21,22,23,24)/p-1/t6-,8-,9-,12?/m1/s1 VDGFGJFPNNGZEH-PUXKXDTASA-M 50370492 CHEMBL607905 Eukaryotic translation initiation factor 4E 220000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370492&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91930060 160849594 CHEMBL607905 ZINC49089312 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825862 CC(C)O[C@H]1[C@@H](COP([O-])(=O)NC(Cc2c[nH]c3ccccc23)C([O-])=O)O[C@H](C1OC(C)C)n1c[nH+]c2c1nc(N)[nH]c2=O InChI=1S/C27H36N7O9P/c1-13(2)41-21-19(43-25(22(21)42-14(3)4)34-12-30-20-23(34)31-27(28)32-24(20)35)11-40-44(38,39)33-18(26(36)37)9-15-10-29-17-8-6-5-7-16(15)17/h5-8,10,12-14,18-19,21-22,25,29H,9,11H2,1-4H3,(H,36,37)(H2,33,38,39)(H3,28,31,32,35)/p-1/t18?,19-,21+,22?,25-/m1/s1 LCPCGPAGEYHJFP-LPFOBZOHSA-M 50165141 CHEMBL436762::disodium 2-amino-9-[(2R,4S,5R)-5-{[({[1-carboxylato-2-(1H-indol-3-yl)ethyl]amino}phosphinato)oxy]methyl}-3,4-bis(propan-2-yloxy)oxolan-2-yl]-6-hydroxy-9H-purin-7-ium Eukaryotic translation initiation factor 4E >400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165141&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91936726 104050728 CHEMBL436762 ZINC28524308 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50825863 CNc1nc2n(cnc2c(=O)[nH]1)C1O[C@H](CO)[C@@H](O)[C@H]1O InChI=1S/C11H15N5O5/c1-12-11-14-8-5(9(20)15-11)13-3-16(8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15,20)/t4-,6-,7-,10?/m1/s1 SLEHROROQDYRAW-VTHZCTBJSA-N 50370493 CHEMBL609636 Eukaryotic translation initiation factor 4E >400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370493&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 46876768 160849595 CHEMBL609636 ZINC49785260 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943215 Nc1nc2n(c[n+](CCOc3ccc(cc3)C(F)(F)F)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C19H21F3N5O9P/c20-19(21,22)9-1-3-10(4-2-9)34-6-5-26-8-27(15-12(26)16(30)25-18(23)24-15)17-14(29)13(28)11(36-17)7-35-37(31,32)33/h1-4,8,11,13-14,17,28-29H,5-7H2,(H4-,23,24,25,30,31,32,33)/t11-,13-,14-,17-/m1/s1 DVJBJHIIUQVOJL-LSCFUAHRSA-N 50386761 CHEMBL2046909 Eukaryotic translation initiation factor 4E 2570 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386761&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57412580 160865844 CHEMBL2046909 ZINC84758903 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943217 C[n+]1cn([C@@H]2O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 InChI=1S/C11H16N5O8P/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(24-10)2-23-25(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H4-,12,13,14,19,20,21,22)/t4-,6-,7-,10-/m1/s1 AOKQNZVJJXPUQA-KQYNXXCUSA-N 50316304 ((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate::CHEMBL1097198 Eukaryotic translation initiation factor 4E 14000 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50316304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50316304&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 14393594 104150665 17825 CHEMBL1097198 C03998 ZINC04096273 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943218 Nc1nc2n(c[n+](Cc3ccccc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C17H20N5O8P/c18-17-19-14-11(15(25)20-17)21(6-9-4-2-1-3-5-9)8-22(14)16-13(24)12(23)10(30-16)7-29-31(26,27)28/h1-5,8,10,12-13,16,23-24H,6-7H2,(H4-,18,19,20,25,26,27,28)/t10-,12-,13-,16-/m1/s1 WMKJRKYLDWLLPS-XNIJJKJLSA-N 50316305 ((2R,3S,4R,5R)-5-(2-amino-7-benzyl-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate::CHEMBL1094975 Eukaryotic translation initiation factor 4E 15500 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50316305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50316305&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search MGQ 2V8X 46886611 104150666 CHEMBL1094975 ZINC16052588 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943219 Nc1nc2n(c[n+](Cc3cccc(Cl)c3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C17H19ClN5O8P/c18-9-3-1-2-8(4-9)5-22-7-23(14-11(22)15(26)21-17(19)20-14)16-13(25)12(24)10(31-16)6-30-32(27,28)29/h1-4,7,10,12-13,16,24-25H,5-6H2,(H4-,19,20,21,26,27,28,29)/t10-,12-,13-,16-/m1/s1 LNHYRHWHNOSCLV-XNIJJKJLSA-N 50316308 ((2R,3S,4R,5R)-5-(2-Amino-7-(3-chlorobenzyl)-6-oxo-1Hpurin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylphosphate::CHEMBL1097199 Eukaryotic translation initiation factor 4E 56800 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50316308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50316308&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 46886616 104150669 CHEMBL1097199 ZINC49113179 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943220 Nc1nc2n(c[n+](Cc3ccccc3Cl)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C17H19ClN5O8P/c18-9-4-2-1-3-8(9)5-22-7-23(14-11(22)15(26)21-17(19)20-14)16-13(25)12(24)10(31-16)6-30-32(27,28)29/h1-4,7,10,12-13,16,24-25H,5-6H2,(H4-,19,20,21,26,27,28,29)/t10-,12-,13-,16-/m1/s1 ZUAWTVARTFVXMM-XNIJJKJLSA-N 50316309 ((2R,3S,4R,5R)-5-(2-Amino-7-(2-chlorobenzyl)-6-oxo-1Hpurin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylphosphate::CHEMBL1095941 Eukaryotic translation initiation factor 4E 54500 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50316309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50316309&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 46886617 104150670 CHEMBL1095941 ZINC49089106 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943221 Nc1nc2n(c[n+](Cc3ccc(Cl)cc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C17H19ClN5O8P/c18-9-3-1-8(2-4-9)5-22-7-23(14-11(22)15(26)21-17(19)20-14)16-13(25)12(24)10(31-16)6-30-32(27,28)29/h1-4,7,10,12-13,16,24-25H,5-6H2,(H4-,19,20,21,26,27,28,29)/t10-,12-,13-,16-/m1/s1 FNDXXZIKXUWWSU-XNIJJKJLSA-N 50316307 ((2R,3S,4R,5R)-5-(2-Amino-7-(4-chlorobenzyl)-6-oxo-1Hpurin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylphosphate::CHEMBL1095620 Eukaryotic translation initiation factor 4E 10000 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50316307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50316307&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 46886615 104150668 CHEMBL1095620 ZINC49089075 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943222 Nc1nc2n(c[n+](CCc3ccc(Cl)cc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C18H21ClN5O8P/c19-10-3-1-9(2-4-10)5-6-23-8-24(15-12(23)16(27)22-18(20)21-15)17-14(26)13(25)11(32-17)7-31-33(28,29)30/h1-4,8,11,13-14,17,25-26H,5-7H2,(H4-,20,21,22,27,28,29,30)/t11-,13-,14-,17-/m1/s1 IOQMIGOOKHIODJ-LSCFUAHRSA-N 50386763 CHEMBL2046902 Eukaryotic translation initiation factor 4E 49300 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386763&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57412496 160865846 CHEMBL2046902 ZINC84757193 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943223 Nc1nc2n(c[n+](CCCc3ccc(Cl)cc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C19H23ClN5O8P/c20-11-5-3-10(4-6-11)2-1-7-24-9-25(16-13(24)17(28)23-19(21)22-16)18-15(27)14(26)12(33-18)8-32-34(29,30)31/h3-6,9,12,14-15,18,26-27H,1-2,7-8H2,(H4-,21,22,23,28,29,30,31)/t12-,14-,15-,18-/m1/s1 XHTWMTCCJRFTGH-SCFUHWHPSA-N 50386764 CHEMBL2046903 Eukaryotic translation initiation factor 4E 5350 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386764&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57412498 160865847 CHEMBL2046903 ZINC84757195 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943224 Nc1nc2n(c[n+](CCOc3ccccc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C18H22N5O9P/c19-18-20-15-12(16(26)21-18)22(6-7-30-10-4-2-1-3-5-10)9-23(15)17-14(25)13(24)11(32-17)8-31-33(27,28)29/h1-5,9,11,13-14,17,24-25H,6-8H2,(H4-,19,20,21,26,27,28,29)/t11-,13-,14-,17-/m1/s1 QENQSKUVFAVVRP-LSCFUAHRSA-N 50386765 CHEMBL2046904 Eukaryotic translation initiation factor 4E 43000 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386765&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57412500 160865848 CHEMBL2046904 ZINC84757198 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943225 Nc1nc2n(c[n+](CCOc3ccc(Cl)cc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C18H21ClN5O9P/c19-9-1-3-10(4-2-9)31-6-5-23-8-24(15-12(23)16(27)22-18(20)21-15)17-14(26)13(25)11(33-17)7-32-34(28,29)30/h1-4,8,11,13-14,17,25-26H,5-7H2,(H4-,20,21,22,27,28,29,30)/t11-,13-,14-,17-/m1/s1 QWFXGVANFMDSMH-LSCFUAHRSA-N 50386766 CHEMBL2046905 Eukaryotic translation initiation factor 4E 59 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386766&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 44817900 160865849 CHEMBL2046905 ZINC84757201 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943226 Nc1nc2n(c[n+](CCOc3ccc(Br)cc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C18H21BrN5O9P/c19-9-1-3-10(4-2-9)31-6-5-23-8-24(15-12(23)16(27)22-18(20)21-15)17-14(26)13(25)11(33-17)7-32-34(28,29)30/h1-4,8,11,13-14,17,25-26H,5-7H2,(H4-,20,21,22,27,28,29,30)/t11-,13-,14-,17-/m1/s1 YCZIVALBOMAUFR-LSCFUAHRSA-N 50386762 CHEMBL2046906 Eukaryotic translation initiation factor 4E 41 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386762&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 46855416 160865845 CHEMBL2046906 ZINC84758934 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943227 Nc1nc2n(c[n+](CCOc3ccc(F)cc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C18H21FN5O9P/c19-9-1-3-10(4-2-9)31-6-5-23-8-24(15-12(23)16(27)22-18(20)21-15)17-14(26)13(25)11(33-17)7-32-34(28,29)30/h1-4,8,11,13-14,17,25-26H,5-7H2,(H4-,20,21,22,27,28,29,30)/t11-,13-,14-,17-/m1/s1 AIPHWKAYHNYRMD-LSCFUAHRSA-N 50386767 CHEMBL2046907 Eukaryotic translation initiation factor 4E 1590 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386767&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57412502 160865850 CHEMBL2046907 ZINC84758935 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943228 Nc1nc2n(c[n+](CCOc3ccc(cc3)C#N)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C19H21N6O9P/c20-7-10-1-3-11(4-2-10)32-6-5-24-9-25(16-13(24)17(28)23-19(21)22-16)18-15(27)14(26)12(34-18)8-33-35(29,30)31/h1-4,9,12,14-15,18,26-27H,5-6,8H2,(H4-,21,22,23,28,29,30,31)/t12-,14-,15-,18-/m1/s1 RHMQELFSDNQEBP-SCFUHWHPSA-N 50386768 CHEMBL2046908 Eukaryotic translation initiation factor 4E 125 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386768&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57412504 160865851 CHEMBL2046908 ZINC84652586 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943229 Nc1nc2n(c[n+](CCOc3ccc(Cl)c(F)c3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C18H20ClFN5O9P/c19-9-2-1-8(5-10(9)20)32-4-3-24-7-25(15-12(24)16(28)23-18(21)22-15)17-14(27)13(26)11(34-17)6-33-35(29,30)31/h1-2,5,7,11,13-14,17,26-27H,3-4,6H2,(H4-,21,22,23,28,29,30,31)/t11-,13-,14-,17-/m1/s1 OSDHZJVAKUMRCL-LSCFUAHRSA-N 50386769 CHEMBL2046910 Eukaryotic translation initiation factor 4E 56 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386769&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57412582 160865852 CHEMBL2046910 ZINC84759181 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943230 Nc1nc2n(c[n+](CC(=O)Nc3ccc(Cl)cc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C18H20ClN6O9P/c19-8-1-3-9(4-2-8)21-11(26)5-24-7-25(15-12(24)16(29)23-18(20)22-15)17-14(28)13(27)10(34-17)6-33-35(30,31)32/h1-4,7,10,13-14,17,27-28H,5-6H2,(H5-,20,21,22,23,26,29,30,31,32)/t10-,13-,14-,17-/m1/s1 UUOOJJLRQGQGFF-IWCJZZDYSA-N 50386770 CHEMBL2046911 Eukaryotic translation initiation factor 4E 85400 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386770&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57412584 160865853 CHEMBL2046911 ZINC84759182 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943231 Nc1nc2n(c[n+](Cc3cc4cc(Cl)ccc4o3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O InChI=1S/C19H19ClN5O9P/c20-9-1-2-11-8(3-9)4-10(33-11)5-24-7-25(16-13(24)17(28)23-19(21)22-16)18-15(27)14(26)12(34-18)6-32-35(29,30)31/h1-4,7,12,14-15,18,26-27H,5-6H2,(H4-,21,22,23,28,29,30,31)/t12-,14-,15-,18-/m1/s1 XCCLFPUBQTZIEH-SCFUHWHPSA-N 50386771 CHEMBL2046912 Eukaryotic translation initiation factor 4E 117 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386771&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57412586 160865854 CHEMBL2046912 ZINC84759183 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943232 Nc1nc2c(cn(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O InChI=1S/C19H22ClN4O9P/c20-9-1-3-10(4-2-9)31-6-5-24-7-11(13-14(24)18(27)23-19(21)22-13)17-16(26)15(25)12(33-17)8-32-34(28,29)30/h1-4,7,12,15-17,25-26H,5-6,8H2,(H2,28,29,30)(H3,21,22,23,27)/t12-,15-,16-,17+/m1/s1 QQCYCDRNMBMNNY-YYQUZTFQSA-N 50386772 CHEMBL2046913 Eukaryotic translation initiation factor 4E 6580 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386772&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 44817902 160865855 CHEMBL2046913 ZINC84654987 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943233 Nc1nc2c(cn(CCOc3ccc(Br)cc3)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O InChI=1S/C19H22BrN4O9P/c20-9-1-3-10(4-2-9)31-6-5-24-7-11(13-14(24)18(27)23-19(21)22-13)17-16(26)15(25)12(33-17)8-32-34(28,29)30/h1-4,7,12,15-17,25-26H,5-6,8H2,(H2,28,29,30)(H3,21,22,23,27)/t12-,15-,16-,17+/m1/s1 GHGNRWFHLZCZOO-YYQUZTFQSA-N 50386773 CHEMBL2046914 Eukaryotic translation initiation factor 4E 3600 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386773&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57412761 160865856 CHEMBL2046914 ZINC84654989 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943234 CC1(C)O[C@@H]2[C@@H](COP(O)([O-])=O)O[C@H]([C@@H]2O1)n1c[n+](CCOc2ccc(Cl)cc2)c2c1nc(N)[nH]c2=O InChI=1S/C21H25ClN5O9P/c1-21(2)35-15-13(9-33-37(29,30)31)34-19(16(15)36-21)27-10-26(14-17(27)24-20(23)25-18(14)28)7-8-32-12-5-3-11(22)4-6-12/h3-6,10,13,15-16,19H,7-9H2,1-2H3,(H4-,23,24,25,28,29,30,31)/t13-,15-,16-,19-/m1/s1 PYFSHRHJFPDMPM-NVQRDWNXSA-N 50386774 CHEMBL2046915 Eukaryotic translation initiation factor 4E 51 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386774&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57412762 160865857 CHEMBL2046915 ZINC84654995 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943235 CNc1nc2nc(-c3ccc(cc3)P(O)(O)=O)n(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1 InChI=1S/C20H19ClN5O5P/c1-22-20-24-17-16(19(27)25-20)26(10-11-31-14-6-4-13(21)5-7-14)18(23-17)12-2-8-15(9-3-12)32(28,29)30/h2-9H,10-11H2,1H3,(H2,28,29,30)(H2,22,24,25,27) MCYZBWKMUOPJOU-UHFFFAOYSA-N 50386775 CHEMBL2046916 Eukaryotic translation initiation factor 4E 95 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386775&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search HLI 4DUM 56932131 160865858 CHEMBL2046916 ZINC84654997 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943236 CNc1nc2nc(-c3ccc(CP(O)(O)=O)cc3)n(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1 InChI=1S/C21H21ClN5O5P/c1-23-21-25-18-17(20(28)26-21)27(10-11-32-16-8-6-15(22)7-9-16)19(24-18)14-4-2-13(3-5-14)12-33(29,30)31/h2-9H,10-12H2,1H3,(H2,29,30,31)(H2,23,25,26,28) CNNKPJYFPGUGLQ-UHFFFAOYSA-N 50386776 CHEMBL2046917 Eukaryotic translation initiation factor 4E 160 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386776&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57412938 160865859 CHEMBL2046917 ZINC84654999 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943237 CNc1nc2nc(-c3ccc(cc3)C(F)(F)P(O)(O)=O)n(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1 InChI=1S/C21H19ClF2N5O5P/c1-25-20-27-17-16(19(30)28-20)29(10-11-34-15-8-6-14(22)7-9-15)18(26-17)12-2-4-13(5-3-12)21(23,24)35(31,32)33/h2-9H,10-11H2,1H3,(H2,31,32,33)(H2,25,27,28,30) ZIPYKPGMJNDUSX-UHFFFAOYSA-N 50386777 CHEMBL2046918 Eukaryotic translation initiation factor 4E 16 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386777&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57413032 160865860 CHEMBL2046918 ZINC84655002 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943238 CCOP(=O)(OCC)c1ccc(cc1)-c1nc2nc(NC)[nH]c(=O)c2n1CCOc1ccc(Cl)cc1 InChI=1S/C24H27ClN5O5P/c1-4-34-36(32,35-5-2)19-12-6-16(7-13-19)22-27-21-20(23(31)29-24(26-3)28-21)30(22)14-15-33-18-10-8-17(25)9-11-18/h6-13H,4-5,14-15H2,1-3H3,(H2,26,28,29,31) XBEXLZNBQGQIAD-UHFFFAOYSA-N 50386778 CHEMBL2046919 Eukaryotic translation initiation factor 4E 300000 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386778&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57412845 160865861 CHEMBL2046919 ZINC84758610 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943239 CCOP(O)(=O)c1ccc(cc1)-c1nc2nc(NC)[nH]c(=O)c2n1CCOc1ccc(Cl)cc1 InChI=1S/C22H23ClN5O5P/c1-3-33-34(30,31)17-10-4-14(5-11-17)20-25-19-18(21(29)27-22(24-2)26-19)28(20)12-13-32-16-8-6-15(23)7-9-16/h4-11H,3,12-13H2,1-2H3,(H,30,31)(H2,24,26,27,29) RVFCWIRYYIYVSJ-UHFFFAOYSA-N 50386779 CHEMBL2046920 Eukaryotic translation initiation factor 4E 1350 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386779&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57412846 160865862 CHEMBL2046920 ZINC84758611 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943240 CNc1nc2nc(-c3ccc(cc3)C(O)=O)n(CCOc3ccc(Cl)cc3)c2c(=O)[nH]1 InChI=1S/C21H18ClN5O4/c1-23-21-25-17-16(19(28)26-21)27(10-11-31-15-8-6-14(22)7-9-15)18(24-17)12-2-4-13(5-3-12)20(29)30/h2-9H,10-11H2,1H3,(H,29,30)(H2,23,25,26,28) HFRKMLGFCHVWTG-UHFFFAOYSA-N 50386780 CHEMBL2046921 Eukaryotic translation initiation factor 4E 3140 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386780&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 57413125 160865863 CHEMBL2046921 ZINC84738990 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 50943251 C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/t4-,6-,7-,10-/m1/s1 DKVRNHPCAOHRSI-KQYNXXCUSA-N 50316302 ((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen triphosphate::CHEMBL1094973 Eukaryotic translation initiation factor 4E 28 ChEMBL 10.1021/jm300037x 10.7270/Q27082GX 22458568 Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50316302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50316302&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search MGP 7MEU,6FBZ,3CTR,7FGG,5TFB,4TPW,6XYA,7V1I,5ZJY,6EVK,6WRZ,5ZK9,5ABX,6GKJ,4EMR,3GDH,7JHE,6SCX,3QJI,5BXV,2WMC,6O80,3AM7,7V1H,8AOW,6FC1,1IPC,1L8B,7JIB,6WVN,5T48,5T46 644349 104150663 74655 CHEMBL1094973 C03517 ZINC24540363 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51000723 COC(=O)C(Cc1ccccc1)NP([O-])(=O)OC[C@H]1O[C@H]([C@H](OC(C)C)[C@@H]1OC(C)C)n1cnc2c1nc(N)[nH]c2=O InChI=1S/C26H37N6O9P/c1-14(2)39-20-18(12-38-42(35,36)31-17(25(34)37-5)11-16-9-7-6-8-10-16)41-24(21(20)40-15(3)4)32-13-28-19-22(32)29-26(27)30-23(19)33/h6-10,13-15,17-18,20-21,24H,11-12H2,1-5H3,(H2,31,35,36)(H3,27,29,30,33)/p-1/t17?,18-,20-,21-,24-/m1/s1 DDTILYYEKMXGSN-RDNHWZOISA-M 50410169 CHEMBL2021409 Eukaryotic translation initiation factor 4E >400000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410169&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91900685 163359193 CHEMBL2021409 ZINC84603694 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51000724 C[n+]1cn([C@H]2C[C@@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)O2)c2nc([NH-])[nH]c(=O)c12 InChI=1S/C11H18N5O13P3/c1-15-4-16(9-8(15)10(18)14-11(12)13-9)7-2-5(17)6(27-7)3-26-31(22,23)29-32(24,25)28-30(19,20)21/h4-7,17H,2-3H2,1H3,(H6-,12,13,14,18,19,20,21,22,23,24,25)/p-4/t5-,6-,7-/m1/s1 CQHSYZKTLHHJNO-FSDSQADBSA-J 50410170 CHEMBL2079703 Eukaryotic translation initiation factor 4E 4000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410170&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91900686 163359194 CHEMBL2079703 C03517 ZINC38140995 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51000725 CC(C)O[C@H]1[C@@H](COP([O-])=O)O[C@H](C1OC(C)C)n1c[n+](Cc2ccccccccc2)c2c1nc([NH-])[nH]c2=O InChI=1S/C27H36N5O7P/c1-17(2)37-22-20(15-36-40(34)35)39-26(23(22)38-18(3)4)32-16-31(21-24(32)29-27(28)30-25(21)33)14-19-12-10-8-6-5-7-9-11-13-19/h5-13,16-18,20,22-23,26,40H,14-15H2,1-4H3,(H3-,28,29,30,33,34,35)/p-1/b6-5-,7-5-,8-6-,9-7-,10-8-,11-9-,12-10-,13-11-,19-12+,19-13+/t20-,22+,23?,26-/m1/s1 YKRLPSSKNFNWHV-ARAGKMDSSA-M 50410171 CHEMBL2079700 Eukaryotic translation initiation factor 4E 70000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410171&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91900687 163359195 CHEMBL2079700 C03498 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51000726 CC(C)OC1C(COP([O-])=O)OC(C1OC(C)C)n1c[n+](C)c2c1nc(N)[n-]c2=O InChI=1S/C17H28N5O7P/c1-8(2)27-12-10(6-26-30(24)25)29-16(13(12)28-9(3)4)22-7-21(5)11-14(22)19-17(18)20-15(11)23/h7-10,12-13,16,30H,6H2,1-5H3,(H3-,18,19,20,23,24,25)/p-1 XPGXBNJOMXYQGK-UHFFFAOYSA-M 50410172 CHEMBL2079724 Eukaryotic translation initiation factor 4E 55000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410172&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91900688 163359196 CHEMBL2079724 C03498 ZINC28524957 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51000727 CC[n+]1cn(C2OC(COP([O-])=O)C(OC(C)C)C2OC(C)C)c2nc(N)[n-]c(=O)c12 InChI=1S/C18H30N5O7P/c1-6-22-8-23(15-12(22)16(24)21-18(19)20-15)17-14(29-10(4)5)13(28-9(2)3)11(30-17)7-27-31(25)26/h8-11,13-14,17,31H,6-7H2,1-5H3,(H3-,19,20,21,24,25,26)/p-1 GOPKSBXOQPQVPI-UHFFFAOYSA-M 50410173 CHEMBL2079719 Eukaryotic translation initiation factor 4E 45000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410173&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91900689 163359197 CHEMBL2079719 C03498 ZINC28521710 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51000728 CC(C)O[C@H]1[C@@H](COP([O-])=O)O[C@H](C1OC(C)C)n1c[n+](Cc2ccccc2)c2c1nc([NH-])[nH]c2=O InChI=1S/C23H32N5O7P/c1-13(2)33-18-16(11-32-36(30)31)35-22(19(18)34-14(3)4)28-12-27(10-15-8-6-5-7-9-15)17-20(28)25-23(24)26-21(17)29/h5-9,12-14,16,18-19,22,36H,10-11H2,1-4H3,(H3-,24,25,26,29,30,31)/p-1/t16-,18+,19?,22-/m1/s1 XUWAFIZZCNEPKH-GNIVAGDMSA-M 50410174 CHEMBL2079702 Eukaryotic translation initiation factor 4E 85000 ChEMBL 10.1016/j.bmcl.2005.01.080 10.7270/Q27D2VWP 15808492 Ghosh, P; Park, C; Peterson, MS; Bitterman, PB; Polunovsky, VA; Wagner, CR University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410174&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 91900690 163359198 CHEMBL2079702 C03498 ZINC28524420 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51109000 C[n+]1cn([C@@H]2O[C@H](Cn3cc(nn3)P(O)([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 InChI=1S/C13H17N8O7P/c1-19-4-21(10-7(19)11(24)16-13(14)15-10)12-9(23)8(22)5(28-12)2-20-3-6(17-18-20)29(25,26)27/h3-5,8-9,12,22-23H,2H2,1H3,(H4-,14,15,16,24,25,26,27)/t5-,8-,9-,12-/m1/s1 OXYNPFVALCVOEE-JJNLEZRASA-N 50452630 CHEMBL4203412 Eukaryotic translation initiation factor 4E 382000 ChEMBL 10.1016/j.bmc.2017.11.032 10.7270/Q2DZ0BWS 29195795 Kozarski, M; Kubacka, D; Wojtczak, BA; Kasprzyk, R; Baranowski, MR; Kowalska, J University of Warsaw http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50452630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50452630&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 145975543 433921461 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51287738 CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(C)=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@]1(C)CCC\C=C/CCC[C@](C)(NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O InChI=1S/C92H149N27O22S2/c1-12-50(5)70(117-84(138)71(51(6)13-2)116-75(129)58(29-24-39-102-89(97)98)108-85(139)72(52(7)120)115-68(124)47-104-53(8)121)83(137)112-63(44-55-31-33-56(122)34-32-55)77(131)111-65(46-69(125)126)79(133)106-59(30-25-40-103-90(99)100)81(135)118-91(9)36-21-16-14-15-17-22-37-92(10,87(141)114-66(48-142)80(134)105-57(28-23-38-101-88(95)96)74(128)109-61(73(94)127)45-67(93)123)119-82(136)60(35-41-143-11)107-76(130)62(42-49(3)4)110-78(132)64(113-86(91)140)43-54-26-19-18-20-27-54/h14-15,18-20,26-27,31-34,49-52,57-66,70-72,120,122,142H,12-13,16-17,21-25,28-30,35-48H2,1-11H3,(H2,93,123)(H2,94,127)(H,104,121)(H,105,134)(H,106,133)(H,107,130)(H,108,139)(H,109,128)(H,110,132)(H,111,131)(H,112,137)(H,113,140)(H,114,141)(H,115,124)(H,116,129)(H,117,138)(H,118,135)(H,119,136)(H,125,126)(H4,95,96,101)(H4,97,98,102)(H4,99,100,103)/b15-14-/t50-,51-,52+,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,70-,71-,72-,91-,92-/m0/s1 YFVARPBUZODTDL-OYPIPQMDSA-N 50525087 CHEMBL4577429 Eukaryotic translation initiation factor 4E 5.3 ChEMBL 10.1021/acs.jmedchem.9b00068 10.7270/Q2JQ14FP 31033289 Gallagher, EE; Song, JM; Menon, A; Mishra, LD; Chmiel, AF; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525087&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155564841 440733669 C02248 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51287739 CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(C)=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O InChI=1S/C89H146N28O24S2/c1-10-46(5)69(117-85(140)70(47(6)11-2)116-78(133)56(25-19-36-101-89(97)98)108-86(141)71(48(7)118)115-66(122)43-102-49(8)119)84(139)113-62(40-51-26-28-52(120)29-27-51)81(136)112-63(42-68(125)126)82(137)104-54(23-17-34-99-87(93)94)73(128)103-53(22-15-16-33-90)75(130)111-61(39-50-20-13-12-14-21-50)80(135)110-60(38-45(3)4)79(134)107-58(32-37-143-9)77(132)106-57(30-31-67(123)124)76(131)114-64(44-142)83(138)105-55(24-18-35-100-88(95)96)74(129)109-59(72(92)127)41-65(91)121/h12-14,20-21,26-29,45-48,53-64,69-71,118,120,142H,10-11,15-19,22-25,30-44,90H2,1-9H3,(H2,91,121)(H2,92,127)(H,102,119)(H,103,128)(H,104,137)(H,105,138)(H,106,132)(H,107,134)(H,108,141)(H,109,129)(H,110,135)(H,111,130)(H,112,136)(H,113,139)(H,114,131)(H,115,122)(H,116,133)(H,117,140)(H,123,124)(H,125,126)(H4,93,94,99)(H4,95,96,100)(H4,97,98,101)/t46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,69-,70-,71-/m0/s1 ZUBOOCCOALVOHE-CWUAZLTLSA-N 50525088 CHEMBL4461497 Eukaryotic translation initiation factor 4E 21 ChEMBL 10.1021/acs.jmedchem.9b00068 10.7270/Q2JQ14FP 31033289 Gallagher, EE; Song, JM; Menon, A; Mishra, LD; Chmiel, AF; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525088&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155528577 440733670 C02248 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51287740 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O InChI=1S/C90H134N24O21/c1-51(2)43-66(77(124)101-50-73(118)103-68(46-55-23-11-7-12-24-55)85(132)108-63(35-37-72(93)117)82(129)109-65(76(94)123)45-54-21-9-6-10-22-54)110-84(131)67(44-52(3)4)111-86(133)69(47-56-25-13-8-14-26-56)113-83(130)64(36-38-74(119)120)107-80(127)61(29-19-41-99-89(95)96)106-88(135)71(49-75(121)122)114-87(134)70(48-57-31-33-58(116)34-32-57)112-81(128)62(30-20-42-100-90(97)98)105-79(126)60(28-16-18-40-92)104-78(125)59(102-53(5)115)27-15-17-39-91/h6-14,21-26,31-34,51-52,59-71,116H,15-20,27-30,35-50,91-92H2,1-5H3,(H2,93,117)(H2,94,123)(H,101,124)(H,102,115)(H,103,118)(H,104,125)(H,105,126)(H,106,135)(H,107,127)(H,108,132)(H,109,129)(H,110,131)(H,111,133)(H,112,128)(H,113,130)(H,114,134)(H,119,120)(H,121,122)(H4,95,96,99)(H4,97,98,100)/t59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-/m0/s1 BCANLOWELFOMRO-ZIUWDTJJSA-N 50525089 CHEMBL4464315 Eukaryotic translation initiation factor 4E 48 ChEMBL 10.1021/acs.jmedchem.9b00068 10.7270/Q2JQ14FP 31033289 Gallagher, EE; Song, JM; Menon, A; Mishra, LD; Chmiel, AF; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525089&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155530634 440733671 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51287741 CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@](C)(CCC\C=C/CCC[C@](C)(NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(C)=O InChI=1S/C97H146N24O19/c1-58(2)51-72-85(132)115-73(52-59(3)4)91(138)121-97(7,93(140)118-75(54-62-31-17-13-18-32-62)87(134)112-70(43-44-78(100)124)84(131)113-71(80(101)127)53-61-29-15-12-16-30-61)46-24-11-9-8-10-23-45-96(6,92(139)119-76(88(135)114-72)55-63-33-19-14-20-34-63)120-90(137)69(38-28-50-107-95(104)105)111-89(136)77(57-79(125)126)117-86(133)74(56-64-39-41-65(123)42-40-64)116-83(130)68(37-27-49-106-94(102)103)110-82(129)67(36-22-26-48-99)109-81(128)66(108-60(5)122)35-21-25-47-98/h8-9,12-20,29-34,39-42,58-59,66-77,123H,10-11,21-28,35-38,43-57,98-99H2,1-7H3,(H2,100,124)(H2,101,127)(H,108,122)(H,109,128)(H,110,129)(H,111,136)(H,112,134)(H,113,131)(H,114,135)(H,115,132)(H,116,130)(H,117,133)(H,118,140)(H,119,139)(H,120,137)(H,121,138)(H,125,126)(H4,102,103,106)(H4,104,105,107)/b9-8-/t66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,96-,97-/m0/s1 HEFXYGBSRCFHEU-VGMKALBYSA-N 50525090 CHEMBL4558213 Eukaryotic translation initiation factor 4E 30 ChEMBL 10.1021/acs.jmedchem.9b00068 10.7270/Q2JQ14FP 31033289 Gallagher, EE; Song, JM; Menon, A; Mishra, LD; Chmiel, AF; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525090&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155557498 440733672 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51287742 CC(C)C[C@H](NC(=O)[C@]1(C)CCC\C=C/CCC[C@](C)(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1)C(N)=O InChI=1S/C75H130N22O16/c1-43(2)38-54(60(79)102)95-71(113)75(9)33-17-13-11-10-12-16-32-74(8,70(112)94-53(30-31-59(78)101)64(106)90-55(39-44(3)4)65(107)91-56(40-45(5)6)69(111)97-75)96-68(110)52(25-21-37-85-73(82)83)89-67(109)58(42-98)93-66(108)57(41-47-26-28-48(100)29-27-47)92-63(105)51(24-20-36-84-72(80)81)88-62(104)50(23-15-19-35-77)87-61(103)49(86-46(7)99)22-14-18-34-76/h10-11,26-29,43-45,49-58,98,100H,12-25,30-42,76-77H2,1-9H3,(H2,78,101)(H2,79,102)(H,86,99)(H,87,103)(H,88,104)(H,89,109)(H,90,106)(H,91,107)(H,92,105)(H,93,108)(H,94,112)(H,95,113)(H,96,110)(H,97,111)(H4,80,81,84)(H4,82,83,85)/b11-10-/t49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,74-,75-/m0/s1 REWHONSUJOGBSP-WVTNLIGWSA-N 50525091 CHEMBL4447089 Eukaryotic translation initiation factor 4E 5.2 ChEMBL 10.1021/acs.jmedchem.9b00068 10.7270/Q2JQ14FP 31033289 Gallagher, EE; Song, JM; Menon, A; Mishra, LD; Chmiel, AF; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525091&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155519198 440733673 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51287743 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O InChI=1S/C90H134N24O21/c1-51(2)43-66(77(124)101-50-73(118)103-68(46-55-23-11-7-12-24-55)85(132)108-63(35-37-72(93)117)82(129)109-65(76(94)123)45-54-21-9-6-10-22-54)110-84(131)67(44-52(3)4)111-86(133)69(47-56-25-13-8-14-26-56)113-83(130)64(36-38-74(119)120)107-80(127)61(29-19-41-99-89(95)96)106-88(135)71(49-75(121)122)114-87(134)70(48-57-31-33-58(116)34-32-57)112-81(128)62(30-20-42-100-90(97)98)105-79(126)60(28-16-18-40-92)104-78(125)59(102-53(5)115)27-15-17-39-91/h6-14,21-26,31-34,51-52,59-71,116H,15-20,27-30,35-50,91-92H2,1-5H3,(H2,93,117)(H2,94,123)(H,101,124)(H,102,115)(H,103,118)(H,104,125)(H,105,126)(H,106,135)(H,107,127)(H,108,132)(H,109,129)(H,110,131)(H,111,133)(H,112,128)(H,113,130)(H,114,134)(H,119,120)(H,121,122)(H4,95,96,99)(H4,97,98,100)/t59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-/m0/s1 BCANLOWELFOMRO-ZIUWDTJJSA-N 50525089 CHEMBL4464315 Eukaryotic translation initiation factor 4E 0.046000 ChEMBL 10.1021/acs.jmedchem.9b00068 10.7270/Q2JQ14FP 31033289 Gallagher, EE; Song, JM; Menon, A; Mishra, LD; Chmiel, AF; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525089&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155530634 440733671 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51287744 CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(C)=O)C(N)=O InChI=1S/C68H118N22O18/c1-36(2)30-48(56(72)98)81-54(95)34-79-57(99)49(31-37(3)4)87-64(106)50(32-38(5)6)88-63(105)46(22-24-53(71)94)85-62(104)47(23-25-55(96)97)86-60(102)44(16-12-28-77-67(73)74)84-66(108)52(35-91)90-65(107)51(33-40-18-20-41(93)21-19-40)89-61(103)45(17-13-29-78-68(75)76)83-59(101)43(15-9-11-27-70)82-58(100)42(80-39(7)92)14-8-10-26-69/h18-21,36-38,42-52,91,93H,8-17,22-35,69-70H2,1-7H3,(H2,71,94)(H2,72,98)(H,79,99)(H,80,92)(H,81,95)(H,82,100)(H,83,101)(H,84,108)(H,85,104)(H,86,102)(H,87,106)(H,88,105)(H,89,103)(H,90,107)(H,96,97)(H4,73,74,77)(H4,75,76,78)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-/m0/s1 VVQCEELTIIOFHE-RZGVDQIZSA-N 50525092 CHEMBL4444144 Eukaryotic translation initiation factor 4E 123 ChEMBL 10.1021/acs.jmedchem.9b00068 10.7270/Q2JQ14FP 31033289 Gallagher, EE; Song, JM; Menon, A; Mishra, LD; Chmiel, AF; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525092&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155516921 440733674 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51287745 CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(C)=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O InChI=1S/C89H146N28O24S2/c1-10-46(5)69(117-85(140)70(47(6)11-2)116-78(133)56(25-19-36-101-89(97)98)108-86(141)71(48(7)118)115-66(122)43-102-49(8)119)84(139)113-62(40-51-26-28-52(120)29-27-51)81(136)112-63(42-68(125)126)82(137)104-54(23-17-34-99-87(93)94)73(128)103-53(22-15-16-33-90)75(130)111-61(39-50-20-13-12-14-21-50)80(135)110-60(38-45(3)4)79(134)107-58(32-37-143-9)77(132)106-57(30-31-67(123)124)76(131)114-64(44-142)83(138)105-55(24-18-35-100-88(95)96)74(129)109-59(72(92)127)41-65(91)121/h12-14,20-21,26-29,45-48,53-64,69-71,118,120,142H,10-11,15-19,22-25,30-44,90H2,1-9H3,(H2,91,121)(H2,92,127)(H,102,119)(H,103,128)(H,104,137)(H,105,138)(H,106,132)(H,107,134)(H,108,141)(H,109,129)(H,110,135)(H,111,130)(H,112,136)(H,113,139)(H,114,131)(H,115,122)(H,116,133)(H,117,140)(H,123,124)(H,125,126)(H4,93,94,99)(H4,95,96,100)(H4,97,98,101)/t46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,69-,70-,71-/m0/s1 ZUBOOCCOALVOHE-CWUAZLTLSA-N 50525088 CHEMBL4461497 Eukaryotic translation initiation factor 4E 0.016000 ChEMBL 10.1021/acs.jmedchem.9b00068 10.7270/Q2JQ14FP 31033289 Gallagher, EE; Song, JM; Menon, A; Mishra, LD; Chmiel, AF; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525088&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155528577 440733670 C02248 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925272 Nc1nc([O-])c2[n+](Cc3ccc(cc3)-c3ccccc3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C23H24N5O8P/c24-23-25-20-17(21(31)26-23)27(10-13-6-8-15(9-7-13)14-4-2-1-3-5-14)12-28(20)22-19(30)18(29)16(36-22)11-35-37(32,33)34/h1-9,12,16,18-19,22,29-30H,10-11H2,(H4-,24,25,26,31,32,33,34)/t16-,18-,19-,22-/m0/s1 BZRSEYMSQVHMLJ-FUOQNJDISA-N 451144 US10676499, Example 1 Eukaryotic translation initiation factor 4E 100.0 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451144&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818469 440827089 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925273 Nc1nc([O-])c2[n+](Cc3ccc(cc3)-c3ccccc3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C23H24N5O8P/c24-23-25-20-17(21(31)26-23)27(10-13-6-8-15(9-7-13)14-4-2-1-3-5-14)12-28(20)22-19(30)18(29)16(36-22)11-35-37(32,33)34/h1-9,12,16,18-19,22,29-30H,10-11H2,(H4-,24,25,26,31,32,33,34)/t16-,18-,19-,22-/m0/s1 BZRSEYMSQVHMLJ-FUOQNJDISA-N 451144 US10676499, Example 1 Eukaryotic translation initiation factor 4E 300 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451144&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818469 440827089 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925274 Nc1nc([O-])c2[n+](Cc3cc4ccccc4s3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C19H20N5O8PS/c20-19-21-16-13(17(27)22-19)23(6-10-5-9-3-1-2-4-12(9)34-10)8-24(16)18-15(26)14(25)11(32-18)7-31-33(28,29)30/h1-5,8,11,14-15,18,25-26H,6-7H2,(H4-,20,21,22,27,28,29,30)/t11-,14-,15-,18-/m0/s1 NSRCYDRNJHJROE-HEWDHTHVSA-N 451145 US10676499, Example 17 Eukaryotic translation initiation factor 4E 30.0 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451145&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818471 440827090 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925275 CO[C@H]1[C@@H](O)[C@H](COP(O)(O)=O)O[C@@H]1n1c[n+](CCOc2ccc(Cl)cc2)c2c([O-])nc(N)nc12 InChI=1S/C19H23ClN5O9P/c1-31-15-14(26)12(8-33-35(28,29)30)34-18(15)25-9-24(13-16(25)22-19(21)23-17(13)27)6-7-32-11-4-2-10(20)3-5-11/h2-5,9,12,14-15,18,26H,6-8H2,1H3,(H4-,21,22,23,27,28,29,30)/t12-,14-,15-,18-/m0/s1 CFUMBUSCNGDNOY-OWCBBSPXSA-N 451146 US10676499, Example 18 Eukaryotic translation initiation factor 4E 180 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451146&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818473 440827091 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925276 CO[C@H]1[C@@H](O)[C@H](COP(O)(O)=O)O[C@@H]1n1c[n+](CCOc2ccc(Cl)cc2)c2c([O-])nc(N)nc12 InChI=1S/C19H23ClN5O9P/c1-31-15-14(26)12(8-33-35(28,29)30)34-18(15)25-9-24(13-16(25)22-19(21)23-17(13)27)6-7-32-11-4-2-10(20)3-5-11/h2-5,9,12,14-15,18,26H,6-8H2,1H3,(H4-,21,22,23,27,28,29,30)/t12-,14-,15-,18-/m0/s1 CFUMBUSCNGDNOY-OWCBBSPXSA-N 451146 US10676499, Example 18 Eukaryotic translation initiation factor 4E 160 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451146&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818473 440827091 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925277 COc1cccc(C[n+]2cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c3nc(N)nc([O-])c23)c1 InChI=1S/C18H22N5O9P/c1-30-10-4-2-3-9(5-10)6-22-8-23(15-12(22)16(26)21-18(19)20-15)17-14(25)13(24)11(32-17)7-31-33(27,28)29/h2-5,8,11,13-14,17,24-25H,6-7H2,1H3,(H4-,19,20,21,26,27,28,29)/t11-,13-,14-,17-/m0/s1 ZYTARHANIGDPTD-MJFSBKNWSA-N 451147 US10676499, Example 26 Eukaryotic translation initiation factor 4E 50.0 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451147&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818475 440827092 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925278 COc1cccc(C[n+]2cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c3nc(N)nc([O-])c23)c1 InChI=1S/C18H22N5O9P/c1-30-10-4-2-3-9(5-10)6-22-8-23(15-12(22)16(26)21-18(19)20-15)17-14(25)13(24)11(32-17)7-31-33(27,28)29/h2-5,8,11,13-14,17,24-25H,6-7H2,1H3,(H4-,19,20,21,26,27,28,29)/t11-,13-,14-,17-/m0/s1 ZYTARHANIGDPTD-MJFSBKNWSA-N 451147 US10676499, Example 26 Eukaryotic translation initiation factor 4E 6500 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451147&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818475 440827092 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925279 Nc1nc([O-])c2[n+](Cc3cccc(OC(F)(F)F)c3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C18H19F3N5O9P/c19-18(20,21)35-9-3-1-2-8(4-9)5-25-7-26(14-11(25)15(29)24-17(22)23-14)16-13(28)12(27)10(34-16)6-33-36(30,31)32/h1-4,7,10,12-13,16,27-28H,5-6H2,(H4-,22,23,24,29,30,31,32)/t10-,12-,13-,16-/m0/s1 WUSCOERYWDHOKT-SDPXSBNPSA-N 451148 US10676499, Example 29 Eukaryotic translation initiation factor 4E 30.0 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451148&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818477 440827093 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925280 Nc1nc([O-])c2[n+](Cc3cccc(OC(F)(F)F)c3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C18H19F3N5O9P/c19-18(20,21)35-9-3-1-2-8(4-9)5-25-7-26(14-11(25)15(29)24-17(22)23-14)16-13(28)12(27)10(34-16)6-33-36(30,31)32/h1-4,7,10,12-13,16,27-28H,5-6H2,(H4-,22,23,24,29,30,31,32)/t10-,12-,13-,16-/m0/s1 WUSCOERYWDHOKT-SDPXSBNPSA-N 451148 US10676499, Example 29 Eukaryotic translation initiation factor 4E 6500 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451148&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818477 440827093 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925281 Nc1nc([O-])c2[n+](Cc3ccccc3CS(=O)(=O)c3ccccc3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C24H26N5O10PS/c25-24-26-21-18(22(32)27-24)28(13-29(21)23-20(31)19(30)17(39-23)11-38-40(33,34)35)10-14-6-4-5-7-15(14)12-41(36,37)16-8-2-1-3-9-16/h1-9,13,17,19-20,23,30-31H,10-12H2,(H4-,25,26,27,32,33,34,35)/t17-,19-,20-,23-/m0/s1 JOFPRJBODRTBBV-UDSSINMLSA-N 451149 US10676499, Example 32 Eukaryotic translation initiation factor 4E 93600 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451149&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818479 440827094 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925282 Nc1nc([O-])c2[n+](Cc3ccccc3CS(=O)(=O)c3ccccc3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C24H26N5O10PS/c25-24-26-21-18(22(32)27-24)28(13-29(21)23-20(31)19(30)17(39-23)11-38-40(33,34)35)10-14-6-4-5-7-15(14)12-41(36,37)16-8-2-1-3-9-16/h1-9,13,17,19-20,23,30-31H,10-12H2,(H4-,25,26,27,32,33,34,35)/t17-,19-,20-,23-/m0/s1 JOFPRJBODRTBBV-UDSSINMLSA-N 451149 US10676499, Example 32 Eukaryotic translation initiation factor 4E 30.0 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451149&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818479 440827094 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925283 Nc1nc([O-])c2[n+](Cc3cccc(Oc4ccccc4)c3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C23H24N5O9P/c24-23-25-20-17(21(31)26-23)27(10-13-5-4-8-15(9-13)36-14-6-2-1-3-7-14)12-28(20)22-19(30)18(29)16(37-22)11-35-38(32,33)34/h1-9,12,16,18-19,22,29-30H,10-11H2,(H4-,24,25,26,31,32,33,34)/t16-,18-,19-,22-/m0/s1 PYDNJFLGBPYTBE-FUOQNJDISA-N 451150 US10676499, Example 33 Eukaryotic translation initiation factor 4E 170 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451150&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818481 440827095 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925284 Nc1nc([O-])c2[n+](Cc3cccc(Oc4ccccc4)c3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C23H24N5O9P/c24-23-25-20-17(21(31)26-23)27(10-13-5-4-8-15(9-13)36-14-6-2-1-3-7-14)12-28(20)22-19(30)18(29)16(37-22)11-35-38(32,33)34/h1-9,12,16,18-19,22,29-30H,10-11H2,(H4-,24,25,26,31,32,33,34)/t16-,18-,19-,22-/m0/s1 PYDNJFLGBPYTBE-FUOQNJDISA-N 451150 US10676499, Example 33 Eukaryotic translation initiation factor 4E 220 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451150&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818481 440827095 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925285 COC(=O)c1sccc1NC(=O)c1cccc(C[n+]2cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c3nc(N)nc([O-])c23)c1 InChI=1S/C24H25N6O11PS/c1-39-23(35)18-13(5-6-43-18)26-20(33)12-4-2-3-11(7-12)8-29-10-30(19-15(29)21(34)28-24(25)27-19)22-17(32)16(31)14(41-22)9-40-42(36,37)38/h2-7,10,14,16-17,22,31-32H,8-9H2,1H3,(H5-,25,26,27,28,33,34,35,36,37,38)/t14-,16-,17-,22-/m0/s1 KSYNXWJQRXRVIL-GTQCGCAASA-N 451151 US10676499, Example 40 Eukaryotic translation initiation factor 4E 2360 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451151&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818483 440827096 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925286 COC(=O)c1sccc1NC(=O)c1cccc(C[n+]2cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c3nc(N)nc([O-])c23)c1 InChI=1S/C24H25N6O11PS/c1-39-23(35)18-13(5-6-43-18)26-20(33)12-4-2-3-11(7-12)8-29-10-30(19-15(29)21(34)28-24(25)27-19)22-17(32)16(31)14(41-22)9-40-42(36,37)38/h2-7,10,14,16-17,22,31-32H,8-9H2,1H3,(H5-,25,26,27,28,33,34,35,36,37,38)/t14-,16-,17-,22-/m0/s1 KSYNXWJQRXRVIL-GTQCGCAASA-N 451151 US10676499, Example 40 Eukaryotic translation initiation factor 4E 6500 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451151&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818483 440827096 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925287 Nc1nc([O-])c2[n+](Cc3cccc(c3)C(=O)Oc3c(Cl)cccc3Cl)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C24H22Cl2N5O10P/c25-13-5-2-6-14(26)19(13)41-23(35)12-4-1-3-11(7-12)8-30-10-31(20-16(30)21(34)29-24(27)28-20)22-18(33)17(32)15(40-22)9-39-42(36,37)38/h1-7,10,15,17-18,22,32-33H,8-9H2,(H4-,27,28,29,34,36,37,38)/t15-,17-,18-,22-/m0/s1 XIOTWTUIFYLOKG-JVGYHMDPSA-N 451152 US10676499, Example 41 Eukaryotic translation initiation factor 4E 8820 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451152&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818485 440827097 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925288 Nc1nc([O-])c2[n+](Cc3cccc(c3)C(=O)Oc3c(Cl)cccc3Cl)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C24H22Cl2N5O10P/c25-13-5-2-6-14(26)19(13)41-23(35)12-4-1-3-11(7-12)8-30-10-31(20-16(30)21(34)29-24(27)28-20)22-18(33)17(32)15(40-22)9-39-42(36,37)38/h1-7,10,15,17-18,22,32-33H,8-9H2,(H4-,27,28,29,34,36,37,38)/t15-,17-,18-,22-/m0/s1 XIOTWTUIFYLOKG-JVGYHMDPSA-N 451152 US10676499, Example 41 Eukaryotic translation initiation factor 4E 20.0 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451152&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818485 440827097 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925289 COC(=O)c1ccsc1NC(=O)c1cccc(C[n+]2cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c3nc(N)nc([O-])c23)c1 InChI=1S/C24H25N6O11PS/c1-39-23(35)13-5-6-43-21(13)27-19(33)12-4-2-3-11(7-12)8-29-10-30(18-15(29)20(34)28-24(25)26-18)22-17(32)16(31)14(41-22)9-40-42(36,37)38/h2-7,10,14,16-17,22,31-32H,8-9H2,1H3,(H5-,25,26,27,28,33,34,35,36,37,38)/t14-,16-,17-,22-/m0/s1 SQUOJOUYLPOCFN-GTQCGCAASA-N 451153 US10676499, Example 42 Eukaryotic translation initiation factor 4E 4900 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451153&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818487 440827098 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925290 COC(=O)c1ccsc1NC(=O)c1cccc(C[n+]2cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c3nc(N)nc([O-])c23)c1 InChI=1S/C24H25N6O11PS/c1-39-23(35)13-5-6-43-21(13)27-19(33)12-4-2-3-11(7-12)8-29-10-30(18-15(29)20(34)28-24(25)26-18)22-17(32)16(31)14(41-22)9-40-42(36,37)38/h2-7,10,14,16-17,22,31-32H,8-9H2,1H3,(H5-,25,26,27,28,33,34,35,36,37,38)/t14-,16-,17-,22-/m0/s1 SQUOJOUYLPOCFN-GTQCGCAASA-N 451153 US10676499, Example 42 Eukaryotic translation initiation factor 4E 6500 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451153&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818487 440827098 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925291 Nc1nc([O-])c2[n+](Cc3cccc(OCc4ccccc4)c3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C24H26N5O9P/c25-24-26-21-18(22(32)27-24)28(10-15-7-4-8-16(9-15)36-11-14-5-2-1-3-6-14)13-29(21)23-20(31)19(30)17(38-23)12-37-39(33,34)35/h1-9,13,17,19-20,23,30-31H,10-12H2,(H4-,25,26,27,32,33,34,35)/t17-,19-,20-,23-/m0/s1 UBNFGWBXIHGDRH-UDSSINMLSA-N 451154 US10676499, Example 43 Eukaryotic translation initiation factor 4E 3170 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451154&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818489 440827099 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925292 Nc1nc([O-])c2[n+](Cc3cccc(OCc4ccccc4)c3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C24H26N5O9P/c25-24-26-21-18(22(32)27-24)28(10-15-7-4-8-16(9-15)36-11-14-5-2-1-3-6-14)13-29(21)23-20(31)19(30)17(38-23)12-37-39(33,34)35/h1-9,13,17,19-20,23,30-31H,10-12H2,(H4-,25,26,27,32,33,34,35)/t17-,19-,20-,23-/m0/s1 UBNFGWBXIHGDRH-UDSSINMLSA-N 451154 US10676499, Example 43 Eukaryotic translation initiation factor 4E 580 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451154&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818489 440827099 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925293 Cc1ccccc1-c1ccc(C[n+]2cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c3nc(N)nc([O-])c23)cc1 InChI=1S/C24H26N5O8P/c1-13-4-2-3-5-16(13)15-8-6-14(7-9-15)10-28-12-29(21-18(28)22(32)27-24(25)26-21)23-20(31)19(30)17(37-23)11-36-38(33,34)35/h2-9,12,17,19-20,23,30-31H,10-11H2,1H3,(H4-,25,26,27,32,33,34,35)/t17-,19-,20-,23-/m0/s1 QEHXAKATIKLRPG-UDSSINMLSA-N 451155 US10676499, Example 49 Eukaryotic translation initiation factor 4E 20.0 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451155&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818491 440827100 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925294 Cc1ccccc1-c1ccc(C[n+]2cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c3nc(N)nc([O-])c23)cc1 InChI=1S/C24H26N5O8P/c1-13-4-2-3-5-16(13)15-8-6-14(7-9-15)10-28-12-29(21-18(28)22(32)27-24(25)26-21)23-20(31)19(30)17(37-23)11-36-38(33,34)35/h2-9,12,17,19-20,23,30-31H,10-11H2,1H3,(H4-,25,26,27,32,33,34,35)/t17-,19-,20-,23-/m0/s1 QEHXAKATIKLRPG-UDSSINMLSA-N 451155 US10676499, Example 49 Eukaryotic translation initiation factor 4E 6500 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451155&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818491 440827100 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925295 COc1cc(ccc1C[n+]1cn([C@H]2O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]2O)c2nc(N)nc([O-])c12)-c1ccccc1 InChI=1S/C24H26N5O9P/c1-36-16-9-14(13-5-3-2-4-6-13)7-8-15(16)10-28-12-29(21-18(28)22(32)27-24(25)26-21)23-20(31)19(30)17(38-23)11-37-39(33,34)35/h2-9,12,17,19-20,23,30-31H,10-11H2,1H3,(H4-,25,26,27,32,33,34,35)/t17-,19-,20-,23-/m0/s1 YHMVJFYSAZOQAW-UDSSINMLSA-N 451156 US10676499, Example 53 Eukaryotic translation initiation factor 4E 190 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451156&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818493 440827101 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925296 COc1cc(ccc1C[n+]1cn([C@H]2O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]2O)c2nc(N)nc([O-])c12)-c1ccccc1 InChI=1S/C24H26N5O9P/c1-36-16-9-14(13-5-3-2-4-6-13)7-8-15(16)10-28-12-29(21-18(28)22(32)27-24(25)26-21)23-20(31)19(30)17(38-23)11-37-39(33,34)35/h2-9,12,17,19-20,23,30-31H,10-11H2,1H3,(H4-,25,26,27,32,33,34,35)/t17-,19-,20-,23-/m0/s1 YHMVJFYSAZOQAW-UDSSINMLSA-N 451156 US10676499, Example 53 Eukaryotic translation initiation factor 4E 6000 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451156&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818493 440827101 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925297 Nc1nc([O-])c2[n+](Cc3ccc(cc3F)-c3ccccc3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C23H23FN5O8P/c24-15-8-13(12-4-2-1-3-5-12)6-7-14(15)9-28-11-29(20-17(28)21(32)27-23(25)26-20)22-19(31)18(30)16(37-22)10-36-38(33,34)35/h1-8,11,16,18-19,22,30-31H,9-10H2,(H4-,25,26,27,32,33,34,35)/t16-,18-,19-,22-/m0/s1 HPWBUUCMGLAISY-FUOQNJDISA-N 451157 US10676499, Example 54 Eukaryotic translation initiation factor 4E 2780 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451157&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818495 440827102 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925298 Nc1nc([O-])c2[n+](Cc3ccc(cc3F)-c3ccccc3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C23H23FN5O8P/c24-15-8-13(12-4-2-1-3-5-12)6-7-14(15)9-28-11-29(20-17(28)21(32)27-23(25)26-20)22-19(31)18(30)16(37-22)10-36-38(33,34)35/h1-8,11,16,18-19,22,30-31H,9-10H2,(H4-,25,26,27,32,33,34,35)/t16-,18-,19-,22-/m0/s1 HPWBUUCMGLAISY-FUOQNJDISA-N 451157 US10676499, Example 54 Eukaryotic translation initiation factor 4E 6000 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451157&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818495 440827102 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925299 Nc1nc([O-])c2[n+](Cc3ccc(c(Cl)c3)-c3ccccc3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C23H23ClN5O8P/c24-15-8-12(6-7-14(15)13-4-2-1-3-5-13)9-28-11-29(20-17(28)21(32)27-23(25)26-20)22-19(31)18(30)16(37-22)10-36-38(33,34)35/h1-8,11,16,18-19,22,30-31H,9-10H2,(H4-,25,26,27,32,33,34,35)/t16-,18-,19-,22-/m0/s1 MZJBWUBXWJHZPF-FUOQNJDISA-N 451158 US10676499, Example 55 Eukaryotic translation initiation factor 4E 40.0 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451158&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818497 440827103 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925300 Nc1nc([O-])c2[n+](Cc3ccc(c(Cl)c3)-c3ccccc3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C23H23ClN5O8P/c24-15-8-12(6-7-14(15)13-4-2-1-3-5-13)9-28-11-29(20-17(28)21(32)27-23(25)26-20)22-19(31)18(30)16(37-22)10-36-38(33,34)35/h1-8,11,16,18-19,22,30-31H,9-10H2,(H4-,25,26,27,32,33,34,35)/t16-,18-,19-,22-/m0/s1 MZJBWUBXWJHZPF-FUOQNJDISA-N 451158 US10676499, Example 55 Eukaryotic translation initiation factor 4E 110 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451158&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818497 440827103 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925301 Nc1nc([O-])c2[n+](Cc3ccc(cc3)-c3cccs3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C21H22N5O8PS/c22-21-23-18-15(19(29)24-21)25(8-11-3-5-12(6-4-11)14-2-1-7-36-14)10-26(18)20-17(28)16(27)13(34-20)9-33-35(30,31)32/h1-7,10,13,16-17,20,27-28H,8-9H2,(H4-,22,23,24,29,30,31,32)/t13-,16-,17-,20-/m0/s1 NQZGCAANOVOWNJ-FDRFZEDHSA-N 451159 US10676499, Example 57 Eukaryotic translation initiation factor 4E 30.0 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451159&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818499 440827104 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925302 Nc1nc([O-])c2[n+](Cc3ccc(cc3)-c3cccs3)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C21H22N5O8PS/c22-21-23-18-15(19(29)24-21)25(8-11-3-5-12(6-4-11)14-2-1-7-36-14)10-26(18)20-17(28)16(27)13(34-20)9-33-35(30,31)32/h1-7,10,13,16-17,20,27-28H,8-9H2,(H4-,22,23,24,29,30,31,32)/t13-,16-,17-,20-/m0/s1 NQZGCAANOVOWNJ-FDRFZEDHSA-N 451159 US10676499, Example 57 Eukaryotic translation initiation factor 4E 6500 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451159&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818499 440827104 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925303 Nc1nc([O-])c2[n+](Cc3ccc(cc3)-c3ccccc3F)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C23H23FN5O8P/c24-15-4-2-1-3-14(15)13-7-5-12(6-8-13)9-28-11-29(20-17(28)21(32)27-23(25)26-20)22-19(31)18(30)16(37-22)10-36-38(33,34)35/h1-8,11,16,18-19,22,30-31H,9-10H2,(H4-,25,26,27,32,33,34,35)/t16-,18-,19-,22-/m0/s1 HCKGKOJRZIRMIP-FUOQNJDISA-N 451160 US10676499, Example 58 Eukaryotic translation initiation factor 4E 1000 US Patent 10.7270/Q2K64N44 aid1804585 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451160&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818501 440827105 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 925304 Nc1nc([O-])c2[n+](Cc3ccc(cc3)-c3ccccc3F)cn([C@H]3O[C@@H](COP(O)(O)=O)[C@H](O)[C@@H]3O)c2n1 InChI=1S/C23H23FN5O8P/c24-15-4-2-1-3-14(15)13-7-5-12(6-8-13)9-28-11-29(20-17(28)21(32)27-23(25)26-20)22-19(31)18(30)16(37-22)10-36-38(33,34)35/h1-8,11,16,18-19,22,30-31H,9-10H2,(H4-,25,26,27,32,33,34,35)/t16-,18-,19-,22-/m0/s1 HCKGKOJRZIRMIP-FUOQNJDISA-N 451160 US10676499, Example 58 Eukaryotic translation initiation factor 4E 410 US Patent 10.7270/Q2K64N44 aid1804586 US10676499 Barnes-Seeman, D; Cohen, SL; Diener, JL; Gampe, C; Roache, J; White, A; Williams, S; Yuan, J; Zecri, F NOVARTIS AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=451160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=451160&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155818501 440827105 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51399971 CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(C)=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O InChI=1S/C89H146N28O24S2/c1-10-46(5)69(117-85(140)70(47(6)11-2)116-78(133)56(25-19-36-101-89(97)98)108-86(141)71(48(7)118)115-66(122)43-102-49(8)119)84(139)113-62(40-51-26-28-52(120)29-27-51)81(136)112-63(42-68(125)126)82(137)104-54(23-17-34-99-87(93)94)73(128)103-53(22-15-16-33-90)75(130)111-61(39-50-20-13-12-14-21-50)80(135)110-60(38-45(3)4)79(134)107-58(32-37-143-9)77(132)106-57(30-31-67(123)124)76(131)114-64(44-142)83(138)105-55(24-18-35-100-88(95)96)74(129)109-59(72(92)127)41-65(91)121/h12-14,20-21,26-29,45-48,53-64,69-71,118,120,142H,10-11,15-19,22-25,30-44,90H2,1-9H3,(H2,91,121)(H2,92,127)(H,102,119)(H,103,128)(H,104,137)(H,105,138)(H,106,132)(H,107,134)(H,108,141)(H,109,129)(H,110,135)(H,111,130)(H,112,136)(H,113,139)(H,114,131)(H,115,122)(H,116,133)(H,117,140)(H,123,124)(H,125,126)(H4,93,94,99)(H4,95,96,100)(H4,97,98,101)/t46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,69-,70-,71-/m0/s1 ZUBOOCCOALVOHE-CWUAZLTLSA-N 50525088 CHEMBL4461497 Eukaryotic translation initiation factor 4E 60 ChEMBL 10.1016/j.ejmech.2020.112655 10.7270/Q2KS6W8F 32739551 Gallagher, EE; Menon, A; Chmiel, AF; Deprey, K; Kritzer, JA; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525088&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155528577 440733670 C02248 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51399972 CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C79H128N24O18S2/c1-9-43(5)62(103-76(121)63(44(6)10-2)102-69(114)50(91-45(7)104)23-17-34-89-78(83)84)75(120)100-57(39-47-25-27-48(105)28-26-47)72(117)99-58(40-61(107)108)73(118)94-52(24-18-35-90-79(85)86)65(110)93-51-21-14-15-32-87-60(106)30-29-53(67(112)101-59(41-122)74(119)92-49(64(80)109)22-16-33-88-77(81)82)95-68(113)54(31-36-123-8)96-70(115)55(37-42(3)4)97-71(116)56(98-66(51)111)38-46-19-12-11-13-20-46/h11-13,19-20,25-28,42-44,49-59,62-63,105,122H,9-10,14-18,21-24,29-41H2,1-8H3,(H2,80,109)(H,87,106)(H,91,104)(H,92,119)(H,93,110)(H,94,118)(H,95,113)(H,96,115)(H,97,116)(H,98,111)(H,99,117)(H,100,120)(H,101,112)(H,102,114)(H,103,121)(H,107,108)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t43-,44-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1 HBSYOUCAUKPLME-AFUKFTIKSA-N 50565475 CHEMBL4777401 Eukaryotic translation initiation factor 4E 22 ChEMBL 10.1016/j.ejmech.2020.112655 10.7270/Q2KS6W8F 32739551 Gallagher, EE; Menon, A; Chmiel, AF; Deprey, K; Kritzer, JA; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565475&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 162642964 461685813 C02248 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51399973 CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C79H128N24O18S2/c1-9-43(5)62(103-76(121)63(44(6)10-2)102-69(114)50(91-45(7)104)23-17-34-89-78(83)84)75(120)100-57(39-47-25-27-48(105)28-26-47)72(117)99-58(40-61(107)108)73(118)94-52(24-18-35-90-79(85)86)65(110)95-53-29-30-60(106)87-32-15-14-21-51(66(111)101-59(41-122)74(119)92-49(64(80)109)22-16-33-88-77(81)82)93-68(113)54(31-36-123-8)96-70(115)55(37-42(3)4)97-71(116)56(98-67(53)112)38-46-19-12-11-13-20-46/h11-13,19-20,25-28,42-44,49-59,62-63,105,122H,9-10,14-18,21-24,29-41H2,1-8H3,(H2,80,109)(H,87,106)(H,91,104)(H,92,119)(H,93,113)(H,94,118)(H,95,110)(H,96,115)(H,97,116)(H,98,112)(H,99,117)(H,100,120)(H,101,111)(H,102,114)(H,103,121)(H,107,108)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t43-,44-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1 CURJMMDVBCSAEU-AFUKFTIKSA-N 50565476 CHEMBL4780117 Eukaryotic translation initiation factor 4E 6.5 ChEMBL 10.1016/j.ejmech.2020.112655 10.7270/Q2KS6W8F 32739551 Gallagher, EE; Menon, A; Chmiel, AF; Deprey, K; Kritzer, JA; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565476&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 162662982 461685814 C02248 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51399974 CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(C)=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O InChI=1S/C89H146N28O24S2/c1-10-46(5)69(117-85(140)70(47(6)11-2)116-78(133)56(25-19-36-101-89(97)98)108-86(141)71(48(7)118)115-66(122)43-102-49(8)119)84(139)113-62(40-51-26-28-52(120)29-27-51)81(136)112-63(42-68(125)126)82(137)104-54(23-17-34-99-87(93)94)73(128)103-53(22-15-16-33-90)75(130)111-61(39-50-20-13-12-14-21-50)80(135)110-60(38-45(3)4)79(134)107-58(32-37-143-9)77(132)106-57(30-31-67(123)124)76(131)114-64(44-142)83(138)105-55(24-18-35-100-88(95)96)74(129)109-59(72(92)127)41-65(91)121/h12-14,20-21,26-29,45-48,53-64,69-71,118,120,142H,10-11,15-19,22-25,30-44,90H2,1-9H3,(H2,91,121)(H2,92,127)(H,102,119)(H,103,128)(H,104,137)(H,105,138)(H,106,132)(H,107,134)(H,108,141)(H,109,129)(H,110,135)(H,111,130)(H,112,136)(H,113,139)(H,114,131)(H,115,122)(H,116,133)(H,117,140)(H,123,124)(H,125,126)(H4,93,94,99)(H4,95,96,100)(H4,97,98,101)/t46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,69-,70-,71-/m0/s1 ZUBOOCCOALVOHE-CWUAZLTLSA-N 50525088 CHEMBL4461497 Eukaryotic translation initiation factor 4E 0.011000 ChEMBL 10.1016/j.ejmech.2020.112655 10.7270/Q2KS6W8F 32739551 Gallagher, EE; Menon, A; Chmiel, AF; Deprey, K; Kritzer, JA; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525088&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155528577 440733670 C02248 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51399975 CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C79H128N24O18S2/c1-9-43(5)62(103-76(121)63(44(6)10-2)102-69(114)50(91-45(7)104)23-17-34-89-78(83)84)75(120)100-57(39-47-25-27-48(105)28-26-47)72(117)99-58(40-61(107)108)73(118)94-52(24-18-35-90-79(85)86)65(110)93-51-21-14-15-32-87-60(106)30-29-53(67(112)101-59(41-122)74(119)92-49(64(80)109)22-16-33-88-77(81)82)95-68(113)54(31-36-123-8)96-70(115)55(37-42(3)4)97-71(116)56(98-66(51)111)38-46-19-12-11-13-20-46/h11-13,19-20,25-28,42-44,49-59,62-63,105,122H,9-10,14-18,21-24,29-41H2,1-8H3,(H2,80,109)(H,87,106)(H,91,104)(H,92,119)(H,93,110)(H,94,118)(H,95,113)(H,96,115)(H,97,116)(H,98,111)(H,99,117)(H,100,120)(H,101,112)(H,102,114)(H,103,121)(H,107,108)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t43-,44-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1 HBSYOUCAUKPLME-AFUKFTIKSA-N 50565475 CHEMBL4777401 Eukaryotic translation initiation factor 4E 0.004200 ChEMBL 10.1016/j.ejmech.2020.112655 10.7270/Q2KS6W8F 32739551 Gallagher, EE; Menon, A; Chmiel, AF; Deprey, K; Kritzer, JA; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565475&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 162642964 461685813 C02248 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51399976 CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C79H128N24O18S2/c1-9-43(5)62(103-76(121)63(44(6)10-2)102-69(114)50(91-45(7)104)23-17-34-89-78(83)84)75(120)100-57(39-47-25-27-48(105)28-26-47)72(117)99-58(40-61(107)108)73(118)94-52(24-18-35-90-79(85)86)65(110)95-53-29-30-60(106)87-32-15-14-21-51(66(111)101-59(41-122)74(119)92-49(64(80)109)22-16-33-88-77(81)82)93-68(113)54(31-36-123-8)96-70(115)55(37-42(3)4)97-71(116)56(98-67(53)112)38-46-19-12-11-13-20-46/h11-13,19-20,25-28,42-44,49-59,62-63,105,122H,9-10,14-18,21-24,29-41H2,1-8H3,(H2,80,109)(H,87,106)(H,91,104)(H,92,119)(H,93,113)(H,94,118)(H,95,110)(H,96,115)(H,97,116)(H,98,112)(H,99,117)(H,100,120)(H,101,111)(H,102,114)(H,103,121)(H,107,108)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t43-,44-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1 CURJMMDVBCSAEU-AFUKFTIKSA-N 50565476 CHEMBL4780117 Eukaryotic translation initiation factor 4E 0.006900 ChEMBL 10.1016/j.ejmech.2020.112655 10.7270/Q2KS6W8F 32739551 Gallagher, EE; Menon, A; Chmiel, AF; Deprey, K; Kritzer, JA; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565476&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 162662982 461685814 C02248 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51399977 CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)CNC(C)=O)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O InChI=1S/C89H146N28O24S2/c1-10-46(5)69(117-85(140)70(47(6)11-2)116-78(133)56(25-19-36-101-89(97)98)108-86(141)71(48(7)118)115-66(122)43-102-49(8)119)84(139)113-62(40-51-26-28-52(120)29-27-51)81(136)112-63(42-68(125)126)82(137)104-54(23-17-34-99-87(93)94)73(128)103-53(22-15-16-33-90)75(130)111-61(39-50-20-13-12-14-21-50)80(135)110-60(38-45(3)4)79(134)107-58(32-37-143-9)77(132)106-57(30-31-67(123)124)76(131)114-64(44-142)83(138)105-55(24-18-35-100-88(95)96)74(129)109-59(72(92)127)41-65(91)121/h12-14,20-21,26-29,45-48,53-64,69-71,118,120,142H,10-11,15-19,22-25,30-44,90H2,1-9H3,(H2,91,121)(H2,92,127)(H,102,119)(H,103,128)(H,104,137)(H,105,138)(H,106,132)(H,107,134)(H,108,141)(H,109,129)(H,110,135)(H,111,130)(H,112,136)(H,113,139)(H,114,131)(H,115,122)(H,116,133)(H,117,140)(H,123,124)(H,125,126)(H4,93,94,99)(H4,95,96,100)(H4,97,98,101)/t46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,69-,70-,71-/m0/s1 ZUBOOCCOALVOHE-CWUAZLTLSA-N 50525088 CHEMBL4461497 Eukaryotic translation initiation factor 4E 17 ChEMBL 10.1016/j.ejmech.2020.112655 10.7270/Q2KS6W8F 32739551 Gallagher, EE; Menon, A; Chmiel, AF; Deprey, K; Kritzer, JA; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525088&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155528577 440733670 C02248 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51399978 CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C79H128N24O18S2/c1-9-43(5)62(103-76(121)63(44(6)10-2)102-69(114)50(91-45(7)104)23-17-34-89-78(83)84)75(120)100-57(39-47-25-27-48(105)28-26-47)72(117)99-58(40-61(107)108)73(118)94-52(24-18-35-90-79(85)86)65(110)93-51-21-14-15-32-87-60(106)30-29-53(67(112)101-59(41-122)74(119)92-49(64(80)109)22-16-33-88-77(81)82)95-68(113)54(31-36-123-8)96-70(115)55(37-42(3)4)97-71(116)56(98-66(51)111)38-46-19-12-11-13-20-46/h11-13,19-20,25-28,42-44,49-59,62-63,105,122H,9-10,14-18,21-24,29-41H2,1-8H3,(H2,80,109)(H,87,106)(H,91,104)(H,92,119)(H,93,110)(H,94,118)(H,95,113)(H,96,115)(H,97,116)(H,98,111)(H,99,117)(H,100,120)(H,101,112)(H,102,114)(H,103,121)(H,107,108)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t43-,44-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1 HBSYOUCAUKPLME-AFUKFTIKSA-N 50565475 CHEMBL4777401 Eukaryotic translation initiation factor 4E 7.2 ChEMBL 10.1016/j.ejmech.2020.112655 10.7270/Q2KS6W8F 32739551 Gallagher, EE; Menon, A; Chmiel, AF; Deprey, K; Kritzer, JA; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565475&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 162642964 461685813 C02248 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51399979 CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C79H128N24O18S2/c1-9-43(5)62(103-76(121)63(44(6)10-2)102-69(114)50(91-45(7)104)23-17-34-89-78(83)84)75(120)100-57(39-47-25-27-48(105)28-26-47)72(117)99-58(40-61(107)108)73(118)94-52(24-18-35-90-79(85)86)65(110)95-53-29-30-60(106)87-32-15-14-21-51(66(111)101-59(41-122)74(119)92-49(64(80)109)22-16-33-88-77(81)82)93-68(113)54(31-36-123-8)96-70(115)55(37-42(3)4)97-71(116)56(98-67(53)112)38-46-19-12-11-13-20-46/h11-13,19-20,25-28,42-44,49-59,62-63,105,122H,9-10,14-18,21-24,29-41H2,1-8H3,(H2,80,109)(H,87,106)(H,91,104)(H,92,119)(H,93,113)(H,94,118)(H,95,110)(H,96,115)(H,97,116)(H,98,112)(H,99,117)(H,100,120)(H,101,111)(H,102,114)(H,103,121)(H,107,108)(H4,81,82,88)(H4,83,84,89)(H4,85,86,90)/t43-,44-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-,63-/m0/s1 CURJMMDVBCSAEU-AFUKFTIKSA-N 50565476 CHEMBL4780117 Eukaryotic translation initiation factor 4E 2.2 ChEMBL 10.1016/j.ejmech.2020.112655 10.7270/Q2KS6W8F 32739551 Gallagher, EE; Menon, A; Chmiel, AF; Deprey, K; Kritzer, JA; Garner, AL University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565476&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 162662982 461685814 C02248 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51413239 OC(=O)C(\Cc1ccccc1[N+]([O-])=O)=N/Nc1nc(cs1)-c1ccc(cc1)-c1ccccc1 InChI=1S/C24H18N4O4S/c29-23(30)20(14-19-8-4-5-9-22(19)28(31)32)26-27-24-25-21(15-33-24)18-12-10-17(11-13-18)16-6-2-1-3-7-16/h1-13,15H,14H2,(H,25,27)(H,29,30)/b26-20- JKEOZOHBIPDTTJ-QOMWVZHYSA-N 50570882 CHEMBL3310358 Eukaryotic translation initiation factor 4E 67500 ChEMBL 10.1016/j.ejmech.2021.113435 10.7270/Q2QV3R91 33892272 Fischer, PD; Papadopoulos, E; Dempersmier, JM; Wang, ZF; Nowak, RP; Donovan, KA; Kalabathula, J; Gorgulla, C; Junghanns, PPM; Kabha, E; Dimitrakakis, N; Petrov, OI; Mitsiades, C; Ducho, C; Gelev, V; Fischer, ES; Wagner, G; Arthanari, H Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570882&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 87511148 471061027 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51413240 OC(=O)C(Cc1ccccc1[N+]([O-])=O)=NNc1nc(cs1)-c1ccc(Cl)c(Cl)c1 InChI=1S/C18H12Cl2N4O4S/c19-12-6-5-10(7-13(12)20)15-9-29-18(21-15)23-22-14(17(25)26)8-11-3-1-2-4-16(11)24(27)28/h1-7,9H,8H2,(H,21,23)(H,25,26)/b22-14- KFRKRECSIYXARE-HMAPJEAMSA-N 50570883 CHEMBL4848695 Eukaryotic translation initiation factor 4E 56800 ChEMBL 10.1016/j.ejmech.2021.113435 10.7270/Q2QV3R91 33892272 Fischer, PD; Papadopoulos, E; Dempersmier, JM; Wang, ZF; Nowak, RP; Donovan, KA; Kalabathula, J; Gorgulla, C; Junghanns, PPM; Kabha, E; Dimitrakakis, N; Petrov, OI; Mitsiades, C; Ducho, C; Gelev, V; Fischer, ES; Wagner, G; Arthanari, H Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570883&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 2831024 471061028 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51456335 Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12 InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) UQPMANVRZYYQMD-UHFFFAOYSA-N 50130693 CGP-57380::CHEMBL1240885 Eukaryotic translation initiation factor 4E 3000 ChEMBL 10.7270/Q20Z777Z 33892273 Jin, X; Yu, R; Wang, X; Proud, CG; Jiang, T Ocean University of China and Laboratory for Marine Drugs and Bioproducts http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50130693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50130693&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 11644425 104022005 CHEMBL1240885 ZINC26969297 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483260 CC1(C)NC(=O)c2ccc(Nc3ccncn3)c(=O)n12 InChI=1S/C13H13N5O2/c1-13(2)17-11(19)9-4-3-8(12(20)18(9)13)16-10-5-6-14-7-15-10/h3-7H,1-2H3,(H,17,19)(H,14,15,16) YUDKTFUCCPOVGR-UHFFFAOYSA-N 164243 US9669031, 2 3,3-dimethyl-6-(pyrimidin-4-ylamino)-2,3-dihydroimidazo[1,5-a]pyridine-1,5-dione (Cpd. No. 2) Eukaryotic translation initiation factor 4E 3800 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=164243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=164243&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search FZJ 6CKI 118598721 373986840 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483261 O=C(Nc1cc(Nc2ccc3C(=O)NCc3c2)ncn1)C1CC1 InChI=1S/C16H15N5O2/c22-15(9-1-2-9)21-14-6-13(18-8-19-14)20-11-3-4-12-10(5-11)7-17-16(12)23/h3-6,8-9H,1-2,7H2,(H,17,23)(H2,18,19,20,21,22) MIVZVCNGBMCBAA-UHFFFAOYSA-N 297345 N-(6-((1-oxoisoindolin-5-yl)amino)pyrimidin-4-yl)cyclopropanecarboxamide (Cpd. No. 12)::US10112955, Example 12 Eukaryotic translation initiation factor 4E 430 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=297345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=297345&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 129071545 381620201 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483262 Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 InChI=1S/C17H20N6O2/c1-10-7-11(21-13-8-12(18)19-9-20-13)16(25)23-14(10)15(24)22-17(23)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H3,18,19,20,21) HKTBYUWLRDZAJK-UHFFFAOYSA-N 50263263 CHEMBL4073443 Eukaryotic translation initiation factor 4E 6.0 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263263&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search N45 6CK6 118598754 404341429 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483263 Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1 InChI=1S/C17H20N6O2/c1-10-7-11(21-13-8-12(18)19-9-20-13)16(25)23-14(10)15(24)22-17(23)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H3,18,19,20,21) HKTBYUWLRDZAJK-UHFFFAOYSA-N 50263263 CHEMBL4073443 Eukaryotic translation initiation factor 4E 1.4 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263263&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search N45 6CK6 118598754 404341429 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483280 CN(Cc1ccon1)Cc1cc(ccc1O)-c1ccnc2cc(Cl)ccc12 InChI=1S/C21H18ClN3O2/c1-25(13-17-7-9-27-24-17)12-15-10-14(2-5-21(15)26)18-6-8-23-20-11-16(22)3-4-19(18)20/h2-11,26H,12-13H2,1H3 JLGFQDAIXIWDPE-UHFFFAOYSA-N 50597691 CHEMBL5182144 Eukaryotic translation initiation factor 4E 6800 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597691&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 136037792 482608543 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483281 CN(Cc1ccon1)Cc1cc(ccc1O)-c1ccnc2cc(Cl)ccc12 InChI=1S/C21H18ClN3O2/c1-25(13-17-7-9-27-24-17)12-15-10-14(2-5-21(15)26)18-6-8-23-20-11-16(22)3-4-19(18)20/h2-11,26H,12-13H2,1H3 JLGFQDAIXIWDPE-UHFFFAOYSA-N 50597691 CHEMBL5182144 Eukaryotic translation initiation factor 4E 6200 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597691&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 136037792 482608543 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483284 CC(C)Oc1cc(F)ccc1Nc1ncnc2cc(C(=O)NCCCN(C)C)n(C)c12 InChI=1S/C22H29FN6O2/c1-14(2)31-19-11-15(23)7-8-16(19)27-21-20-17(25-13-26-21)12-18(29(20)5)22(30)24-9-6-10-28(3)4/h7-8,11-14H,6,9-10H2,1-5H3,(H,24,30)(H,25,26,27) CLIORPUQKOJRDE-UHFFFAOYSA-N 50597671 CHEMBL5186068 Eukaryotic translation initiation factor 4E 40 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597671&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 137351430 482608523 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483285 CC(C)Oc1cc(ccc1Nc1ncnc2ccn(C)c12)C#N InChI=1S/C17H17N5O/c1-11(2)23-15-8-12(9-18)4-5-13(15)21-17-16-14(19-10-20-17)6-7-22(16)3/h4-8,10-11H,1-3H3,(H,19,20,21) FOQNSWUDBARUFL-UHFFFAOYSA-N 50597672 CHEMBL5195560 Eukaryotic translation initiation factor 4E 32 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597672&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 137352106 482608524 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483286 Cn1ccc2ncnc(Nc3ccc(F)cc3OC(CF)CF)c12 InChI=1S/C16H15F3N4O/c1-23-5-4-13-15(23)16(21-9-20-13)22-12-3-2-10(19)6-14(12)24-11(7-17)8-18/h2-6,9,11H,7-8H2,1H3,(H,20,21,22) HIIXSKLGSBCTAH-UHFFFAOYSA-N 50597673 CHEMBL5175341 Eukaryotic translation initiation factor 4E 20 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597673&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 137351813 482608525 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483287 Cn1ccc2ncnc(Nc3ccc(F)cc3O[C@@H]3CCCOC3)c12 InChI=1S/C18H19FN4O2/c1-23-7-6-15-17(23)18(21-11-20-15)22-14-5-4-12(19)9-16(14)25-13-3-2-8-24-10-13/h4-7,9,11,13H,2-3,8,10H2,1H3,(H,20,21,22)/t13-/m1/s1 WSLNKDCNHNOGHL-CYBMUJFWSA-N 50597674 CHEMBL5187414 Eukaryotic translation initiation factor 4E 20 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597674&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 137351915 482608526 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483288 Cn1ccc2ncnc(Nc3ccc(F)cc3OC3CCCC3)c12 InChI=1S/C18H19FN4O/c1-23-9-8-15-17(23)18(21-11-20-15)22-14-7-6-12(19)10-16(14)24-13-4-2-3-5-13/h6-11,13H,2-5H2,1H3,(H,20,21,22) GQPLXSNGJYAHSH-UHFFFAOYSA-N 50597675 CHEMBL5184155 Eukaryotic translation initiation factor 4E 20 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597675&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 137351394 482608527 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483289 CN(C)CCCNC(=O)c1cc2ncnc(N3CCc4cc(F)ccc34)c2n1C InChI=1S/C21H25FN6O/c1-26(2)9-4-8-23-21(29)18-12-16-19(27(18)3)20(25-13-24-16)28-10-7-14-11-15(22)5-6-17(14)28/h5-6,11-13H,4,7-10H2,1-3H3,(H,23,29) KXZLWAAQYGMLJX-UHFFFAOYSA-N 50597676 CHEMBL5196084 Eukaryotic translation initiation factor 4E 25 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597676&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 168287174 482608528 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483290 CC(C)Oc1cc(F)ccc1Nc1ncnc2cc(C(=O)NCC3CCNCC3)n(C)c12 InChI=1S/C23H29FN6O2/c1-14(2)32-20-10-16(24)4-5-17(20)29-22-21-18(27-13-28-22)11-19(30(21)3)23(31)26-12-15-6-8-25-9-7-15/h4-5,10-11,13-15,25H,6-9,12H2,1-3H3,(H,26,31)(H,27,28,29) UUQZSFPVUKCRKO-UHFFFAOYSA-N 50597677 CHEMBL5203734 Eukaryotic translation initiation factor 4E 200 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597677&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 137352544 482608529 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483291 Fc1ccc2N(CCc2c1)c1ncnc2cc[nH]c12 InChI=1S/C14H11FN4/c15-10-1-2-12-9(7-10)4-6-19(12)14-13-11(3-5-16-13)17-8-18-14/h1-3,5,7-8,16H,4,6H2 KVGHGVHKZQAQLD-UHFFFAOYSA-N 50597678 CHEMBL5183411 Eukaryotic translation initiation factor 4E 50 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597678&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 137351573 482608530 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483292 CNC(=O)c1nc2c(Nc3ccc(F)cc3OC(C)C)ncnc2s1 InChI=1S/C16H16FN5O2S/c1-8(2)24-11-6-9(17)4-5-10(11)21-13-12-15(20-7-19-13)25-16(22-12)14(23)18-3/h4-8H,1-3H3,(H,18,23)(H,19,20,21) DPFZKILBVWKIDP-UHFFFAOYSA-N 50597679 CHEMBL5195407 Eukaryotic translation initiation factor 4E 25 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597679&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 135334231 482608531 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483293 CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(nc12)C(=O)NCCN1CCNCC1 InChI=1S/C21H26FN7O2S/c1-13(2)31-16-11-14(22)3-4-15(16)27-18-17-20(26-12-25-18)32-21(28-17)19(30)24-7-10-29-8-5-23-6-9-29/h3-4,11-13,23H,5-10H2,1-2H3,(H,24,30)(H,25,26,27) QUVIEDJGNUFDDH-UHFFFAOYSA-N 50597680 CHEMBL5205835 Eukaryotic translation initiation factor 4E 40 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597680&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 135390322 482608532 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483294 CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(nc12)C(=O)NCC1CCNCC1 InChI=1S/C21H25FN6O2S/c1-12(2)30-16-9-14(22)3-4-15(16)27-18-17-20(26-11-25-18)31-21(28-17)19(29)24-10-13-5-7-23-8-6-13/h3-4,9,11-13,23H,5-8,10H2,1-2H3,(H,24,29)(H,25,26,27) FPQBGLUWBCLXFG-UHFFFAOYSA-N 50597681 CHEMBL5197975 Eukaryotic translation initiation factor 4E 79 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597681&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 135390238 482608533 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483295 CN(C)CCCNC(=O)c1nc2c(ncnc2s1)N1CC(C)(C)c2ccccc12 InChI=1S/C21H26N6OS/c1-21(2)12-27(15-9-6-5-8-14(15)21)17-16-19(24-13-23-17)29-20(25-16)18(28)22-10-7-11-26(3)4/h5-6,8-9,13H,7,10-12H2,1-4H3,(H,22,28) LVSWSCZOVNFBCZ-UHFFFAOYSA-N 50597682 CHEMBL5206647 Eukaryotic translation initiation factor 4E 16 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597682&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 135390267 482608534 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483296 CN(C)CCCNC(=O)c1nc2c(ncnc2s1)N1CCc2ccccc12 InChI=1S/C19H22N6OS/c1-24(2)10-5-9-20-17(26)19-23-15-16(21-12-22-18(15)27-19)25-11-8-13-6-3-4-7-14(13)25/h3-4,6-7,12H,5,8-11H2,1-2H3,(H,20,26) CXNIDEGZWPEOCF-UHFFFAOYSA-N 50597683 CHEMBL5171562 Eukaryotic translation initiation factor 4E 32 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597683&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 135334241 482608535 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483297 Fc1ccc2N(CCc2c1)c1ncnc2sc(nc12)C(=O)NCC1CCNCC1 InChI=1S/C20H21FN6OS/c21-14-1-2-15-13(9-14)5-8-27(15)17-16-19(25-11-24-17)29-20(26-16)18(28)23-10-12-3-6-22-7-4-12/h1-2,9,11-12,22H,3-8,10H2,(H,23,28) BTVOPBCDBRHMPF-UHFFFAOYSA-N 50597684 CHEMBL5203720 Eukaryotic translation initiation factor 4E 7.9 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597684&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 135390569 482608536 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483298 CN(C)CCCNC(=O)c1nc2c(ncnc2s1)N1CCc2cc(F)ccc12 InChI=1S/C19H21FN6OS/c1-25(2)8-3-7-21-17(27)19-24-15-16(22-11-23-18(15)28-19)26-9-6-12-10-13(20)4-5-14(12)26/h4-5,10-11H,3,6-9H2,1-2H3,(H,21,27) CYFVVHXJLAKHJY-UHFFFAOYSA-N 50597685 CHEMBL5181488 Eukaryotic translation initiation factor 4E 7.9 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597685&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 135333935 482608537 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483299 CC1(C)CN(c2ccccc12)c1ncnc2sc(nc12)C(=O)NCC1CCNCC1 InChI=1S/C22H26N6OS/c1-22(2)12-28(16-6-4-3-5-15(16)22)18-17-20(26-13-25-18)30-21(27-17)19(29)24-11-14-7-9-23-10-8-14/h3-6,13-14,23H,7-12H2,1-2H3,(H,24,29) NQKUBPWGXDRNCR-UHFFFAOYSA-N 50597686 CHEMBL5183975 Eukaryotic translation initiation factor 4E 3.2 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597686&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 145743795 482608538 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51483300 Clc1ccc2N(CCc2c1)c1ncnc2sc(nc12)C(=O)NCC1CCNCC1 InChI=1S/C20H21ClN6OS/c21-14-1-2-15-13(9-14)5-8-27(15)17-16-19(25-11-24-17)29-20(26-16)18(28)23-10-12-3-6-22-7-4-12/h1-2,9,11-12,22H,3-8,10H2,(H,23,28) XZUIPTFXIKGMGA-UHFFFAOYSA-N 50597687 CHEMBL5180948 Eukaryotic translation initiation factor 4E 32 ChEMBL 10.7270/Q20C50T2 34533957 Xu, W; Kannan, S; Verma, CS; Nacro, K A*STAR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50597687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50597687&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 135333839 482608539 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51510114 OC(=O)C(=N/Nc1ncc(s1)-c1ccc(Cl)c(Cl)c1)\c1ccccc1[N+]([O-])=O InChI=1S/C17H10Cl2N4O4S/c18-11-6-5-9(7-12(11)19)14-8-20-17(28-14)22-21-15(16(24)25)10-3-1-2-4-13(10)23(26)27/h1-8H,(H,20,22)(H,24,25)/b21-15- MVJZGVTUJQAVFI-QNGOZBTKSA-N 50607960 CHEMBL5289039 Eukaryotic translation initiation factor 4E 25000 ChEMBL 10.7270/Q2T43Z96 33592144 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50607960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50607960&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 171351253 494497708 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51525473 C[n+]1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/p+1/t4-,6-,7-,10-/m1/s1 DKVRNHPCAOHRSI-KQYNXXCUSA-O 50613700 CHEBI:50226::CHEMBL1234303 Eukaryotic translation initiation factor 4E 370 ChEMBL 10.7270/Q27D30DF 27592390 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50613700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50613700&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 135419182 494503448 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51525474 C[n+]1cn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 InChI=1S/C11H16N5O8P/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(24-10)2-23-25(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H4-,12,13,14,19,20,21,22)/p+1/t4-,6-,7-,10-/m1/s1 AOKQNZVJJXPUQA-KQYNXXCUSA-O 50613701 CHEBI:17825::CHEMBL1232939 Eukaryotic translation initiation factor 4E 3900 ChEMBL 10.7270/Q27D30DF 27592390 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50613701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50613701&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 135398701 494503449 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51525475 Nc1nc2n(c[n+](Cc3ccccc3)c2c(=O)[nH]1)[C@@H]1O[C@H](CNS(=O)(=O)C(F)(F)F)[C@@H](O)[C@H]1O InChI=1S/C18H19F3N6O6S/c19-18(20,21)34(31,32)23-6-10-12(28)13(29)16(33-10)27-8-26(7-9-4-2-1-3-5-9)11-14(27)24-17(22)25-15(11)30/h1-5,8,10,12-13,16,23,28-29H,6-7H2,(H2-,22,24,25,30)/p+1/t10-,12-,13-,16-/m1/s1 NMFHLBUCTTXCHX-XNIJJKJLSA-O 50613702 CHEMBL5282449 Eukaryotic translation initiation factor 4E 56500 ChEMBL 10.7270/Q27D30DF 27592390 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50613702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50613702&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 135567093 494503450 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51525476 C[n+]1cn([C@@H]2O[C@H](CNS(=O)(=O)c3ccc(cc3)C(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 InChI=1S/C18H20N6O8S/c1-23-7-24(14-11(23)15(27)22-18(19)21-14)16-13(26)12(25)10(32-16)6-20-33(30,31)9-4-2-8(3-5-9)17(28)29/h2-5,7,10,12-13,16,20,25-26H,6H2,1H3,(H3-,19,21,22,27,28,29)/p+1/t10-,12-,13-,16-/m1/s1 AWWBCTMRCFTUFB-XNIJJKJLSA-O 50613703 CHEMBL5286550 Eukaryotic translation initiation factor 4E 133000 ChEMBL 10.7270/Q27D30DF 27592390 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50613703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50613703&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 171348349 494503451 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51525477 CC(C)CNC(=S)N(Cc1ccccc1)Cc1cc2cc3OCOc3cc2[nH]c1=O InChI=1S/C23H25N3O3S/c1-15(2)11-24-23(30)26(12-16-6-4-3-5-7-16)13-18-8-17-9-20-21(29-14-28-20)10-19(17)25-22(18)27/h3-10,15H,11-14H2,1-2H3,(H,24,30)(H,25,27) JBPVNZAVPAZFCW-UHFFFAOYSA-N 50613704 CHEMBL5283082 Eukaryotic translation initiation factor 4E 57800 ChEMBL 10.7270/Q27D30DF 27592390 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50613704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50613704&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 3175571 494503452 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51525478 CC(C)CNC(=S)N(Cc1ccccc1)Cc1cc2cc3OCOc3cc2[nH]c1=O InChI=1S/C23H25N3O3S/c1-15(2)11-24-23(30)26(12-16-6-4-3-5-7-16)13-18-8-17-9-20-21(29-14-28-20)10-19(17)25-22(18)27/h3-10,15H,11-14H2,1-2H3,(H,24,30)(H,25,27) JBPVNZAVPAZFCW-UHFFFAOYSA-N 50613704 CHEMBL5283082 Eukaryotic translation initiation factor 4E 38600 ChEMBL 10.7270/Q27D30DF 27592390 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50613704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50613704&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 3175571 494503452 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51525479 C[n+]1cn([C@@H]2O[C@H](CNS(=O)(=O)c3ccc(cc3)C(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 InChI=1S/C18H20N6O8S/c1-23-7-24(14-11(23)15(27)22-18(19)21-14)16-13(26)12(25)10(32-16)6-20-33(30,31)9-4-2-8(3-5-9)17(28)29/h2-5,7,10,12-13,16,20,25-26H,6H2,1H3,(H3-,19,21,22,27,28,29)/p+1/t10-,12-,13-,16-/m1/s1 AWWBCTMRCFTUFB-XNIJJKJLSA-O 50613703 CHEMBL5286550 Eukaryotic translation initiation factor 4E 18700 ChEMBL 10.7270/Q27D30DF 27592390 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50613703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50613703&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 171348349 494503451 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51525480 Nc1nc2n(c[n+](Cc3ccccc3)c2c(=O)[nH]1)[C@@H]1O[C@H](CNS(=O)(=O)C(F)(F)F)[C@@H](O)[C@H]1O InChI=1S/C18H19F3N6O6S/c19-18(20,21)34(31,32)23-6-10-12(28)13(29)16(33-10)27-8-26(7-9-4-2-1-3-5-9)11-14(27)24-17(22)25-15(11)30/h1-5,8,10,12-13,16,23,28-29H,6-7H2,(H2-,22,24,25,30)/p+1/t10-,12-,13-,16-/m1/s1 NMFHLBUCTTXCHX-XNIJJKJLSA-O 50613702 CHEMBL5282449 Eukaryotic translation initiation factor 4E 12600 ChEMBL 10.7270/Q27D30DF 27592390 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50613702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50613702&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 135567093 494503450 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51525481 C[n+]1cn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 InChI=1S/C11H16N5O8P/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(24-10)2-23-25(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H4-,12,13,14,19,20,21,22)/p+1/t4-,6-,7-,10-/m1/s1 AOKQNZVJJXPUQA-KQYNXXCUSA-O 50613701 CHEBI:17825::CHEMBL1232939 Eukaryotic translation initiation factor 4E 1700 ChEMBL 10.7270/Q27D30DF 27592390 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50613701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50613701&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 135398701 494503449 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51525482 C[n+]1cn([C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/p+1/t4-,6-,7-,10-/m1/s1 DKVRNHPCAOHRSI-KQYNXXCUSA-O 50613700 CHEBI:50226::CHEMBL1234303 Eukaryotic translation initiation factor 4E 720 ChEMBL 10.7270/Q27D30DF 27592390 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50613700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50613700&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 135419182 494503448 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 1IPB,1IPC,1WKW,2GPQ,2V8W,2V8X,2V8Y,2W97,3AM7,3TF2,3U7X,4AZA,4BEA,4DT6,4DUM,4TPW,4TQB,4TQC,5EHC,5EI3,5EIR,5EKV,5T46,5ZJY,5ZJZ,5ZK5,5ZK7,5ZK9,5ZML,7D6Y,7D8B,7EZW,7F07,7MEU,7XTP,8SX4 Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51554895 NC(=O)c1ncn(n1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O InChI=1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 50154375 Adenosine receptor agonist, 16::Ribavirin::Tribavirin::cid_37542::med.21724, Compound 180 Eukaryotic translation initiation factor 4E Homo sapiens 8400 ChEMBL 10.1039/d3md00121k 10.7270/Q2XW4Q6V 37360400 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50154375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50154375&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search RBV 8TZ1,8KI6,5AXD,4PB1,3SFU 37542 252819749 63580 DB00811 6842 ZINC01035331 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 5T46,7XTP,7F07,7EZW,7D8B,7D6Y,5EKV,5EIR,5EI3,5EHC,4BEA,4AZA,3U7X,3TF2,2W97,2V8Y,2V8X,2V8W,2GPQ,1IPC,1IPB,4DUM,4DT6,5ZML,3AM7,1WKW,7MEU,8SX4,5ZK9,5ZK7,5ZK5,5ZJZ,5ZJY,4TQC,4TQB,4TPW Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51554896 O=C(N1CCOCC1)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2c1 InChI=1S/C25H20N4O2/c26-15-18-1-3-20(4-2-18)23-16-27-24-10-9-22(17-29(23)24)19-5-7-21(8-6-19)25(30)28-11-13-31-14-12-28/h1-10,16-17H,11-14H2 FWRFPHJSGLYXTD-UHFFFAOYSA-N 375544 4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile::US9908886, Example 96 Eukaryotic translation initiation factor 4E Homo sapiens 321 ChEMBL 10.1039/d3md00121k 10.7270/Q2XW4Q6V 37360400 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=375544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=375544&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search X8K 8P9B 71766360 404344575 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 5T46,7XTP,7F07,7EZW,7D8B,7D6Y,5EKV,5EIR,5EI3,5EHC,4BEA,4AZA,3U7X,3TF2,2W97,2V8Y,2V8X,2V8W,2GPQ,1IPC,1IPB,4DUM,4DT6,5ZML,3AM7,1WKW,7MEU,8SX4,5ZK9,5ZK7,5ZK5,5ZJZ,5ZJY,4TQC,4TQB,4TPW Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51554897 CC(C)Oc1cc(ccc1C(N)=O)-c1cncc(c1)-c1cnn(c1)C1COC1 InChI=1S/C21H22N4O3/c1-13(2)28-20-6-14(3-4-19(20)21(22)26)15-5-16(8-23-7-15)17-9-24-25(10-17)18-11-27-12-18/h3-10,13,18H,11-12H2,1-2H3,(H2,22,26) FXMBSEOFWALADX-UHFFFAOYSA-N 50520253 CHEMBL4587832 Eukaryotic translation initiation factor 4E Homo sapiens 200 ChEMBL 10.1039/d3md00121k 10.7270/Q2XW4Q6V 37360400 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50520253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50520253&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 155567311 440728835 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 5T46,7XTP,7F07,7EZW,7D8B,7D6Y,5EKV,5EIR,5EI3,5EHC,4BEA,4AZA,3U7X,3TF2,2W97,2V8Y,2V8X,2V8W,2GPQ,1IPC,1IPB,4DUM,4DT6,5ZML,3AM7,1WKW,7MEU,8SX4,5ZK9,5ZK7,5ZK5,5ZJZ,5ZJY,4TQC,4TQB,4TPW Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51554898 CN1CCN(Cc2ccc(NC(=O)CNc3ccc(cc3F)-c3ccc(NC(=O)C4CC4)nc3)cc2C(F)(F)F)CC1 InChI=1S/C30H32F4N6O2/c1-39-10-12-40(13-11-39)18-22-4-7-23(15-24(22)30(32,33)34)37-28(41)17-35-26-8-5-20(14-25(26)31)21-6-9-27(36-16-21)38-29(42)19-2-3-19/h4-9,14-16,19,35H,2-3,10-13,17-18H2,1H3,(H,37,41)(H,36,38,42) CGMQSJXTBXHOTH-UHFFFAOYSA-N 50170221 CHEMBL3806189 Eukaryotic translation initiation factor 4E Homo sapiens 280 ChEMBL 10.1039/d3md00121k 10.7270/Q2XW4Q6V 37360400 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50170221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50170221&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 73438493 341104907 CHEMBL3806189 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 5T46,7XTP,7F07,7EZW,7D8B,7D6Y,5EKV,5EIR,5EI3,5EHC,4BEA,4AZA,3U7X,3TF2,2W97,2V8Y,2V8X,2V8W,2GPQ,1IPC,1IPB,4DUM,4DT6,5ZML,3AM7,1WKW,7MEU,8SX4,5ZK9,5ZK7,5ZK5,5ZJZ,5ZJY,4TQC,4TQB,4TPW Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51558364 C[n+]1cn(C\C=C/CP(O)(O)=O)c2nc(N)[nH]c(=O)c12 InChI=1S/C10H14N5O4P/c1-14-6-15(4-2-3-5-20(17,18)19)8-7(14)9(16)13-10(11)12-8/h2-3,6H,4-5H2,1H3,(H4-,11,12,13,16,17,18,19)/p+1/b3-2- KVAZAUATOPVVRV-IHWYPQMZSA-O 50627248 CHEMBL5397680 Eukaryotic translation initiation factor 4E Homo sapiens 16000 ChEMBL 10.1021/acs.jmedchem.3c00917 10.7270/Q2QN6C66 37471629 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627248&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 5T46,7XTP,7F07,7EZW,7D8B,7D6Y,5EKV,5EIR,5EI3,5EHC,4BEA,4AZA,3U7X,3TF2,2W97,2V8Y,2V8X,2V8W,2GPQ,1IPC,1IPB,4DUM,4DT6,5ZML,3AM7,1WKW,7MEU,8SX4,5ZK9,5ZK7,5ZK5,5ZJZ,5ZJY,4TQC,4TQB,4TPW Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51558365 Nc1nc2n(C\C=C/CP(O)(O)=O)c[n+](Cc3ccc(Cl)cc3)c2c(=O)[nH]1 InChI=1S/C16H17ClN5O4P/c17-12-5-3-11(4-6-12)9-22-10-21(7-1-2-8-27(24,25)26)14-13(22)15(23)20-16(18)19-14/h1-6,10H,7-9H2,(H4-,18,19,20,23,24,25,26)/p+1/b2-1- VPYBINFRTAKGSW-UPHRSURJSA-O 50627249 CHEMBL5421043 Eukaryotic translation initiation factor 4E Homo sapiens 58000 ChEMBL 10.1021/acs.jmedchem.3c00917 10.7270/Q2QN6C66 37471629 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627249&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 5T46,7XTP,7F07,7EZW,7D8B,7D6Y,5EKV,5EIR,5EI3,5EHC,4BEA,4AZA,3U7X,3TF2,2W97,2V8Y,2V8X,2V8W,2GPQ,1IPC,1IPB,4DUM,4DT6,5ZML,3AM7,1WKW,7MEU,8SX4,5ZK9,5ZK7,5ZK5,5ZJZ,5ZJY,4TQC,4TQB,4TPW Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51558366 Nc1nc2n(C\C=C/CP(O)(O)=O)c[n+](Cc3ccc(cc3)-c3ccccc3)c2c(=O)[nH]1 InChI=1S/C22H22N5O4P/c23-22-24-20-19(21(28)25-22)27(15-26(20)12-4-5-13-32(29,30)31)14-16-8-10-18(11-9-16)17-6-2-1-3-7-17/h1-11,15H,12-14H2,(H4-,23,24,25,28,29,30,31)/p+1/b5-4- MEHZPFNZEGNOQM-PLNGDYQASA-O 50627250 CHEMBL5401394 Eukaryotic translation initiation factor 4E Homo sapiens 10000 ChEMBL 10.1021/acs.jmedchem.3c00917 10.7270/Q2QN6C66 37471629 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627250&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 5T46,7XTP,7F07,7EZW,7D8B,7D6Y,5EKV,5EIR,5EI3,5EHC,4BEA,4AZA,3U7X,3TF2,2W97,2V8Y,2V8X,2V8W,2GPQ,1IPC,1IPB,4DUM,4DT6,5ZML,3AM7,1WKW,7MEU,8SX4,5ZK9,5ZK7,5ZK5,5ZJZ,5ZJY,4TQC,4TQB,4TPW Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51558367 Nc1nc2n(C\C=C/CP(O)(O)=O)c[n+](CCOc3ccc(Cl)cc3)c2c(=O)[nH]1 InChI=1S/C17H19ClN5O5P/c18-12-3-5-13(6-4-12)28-9-8-22-11-23(7-1-2-10-29(25,26)27)15-14(22)16(24)21-17(19)20-15/h1-6,11H,7-10H2,(H4-,19,20,21,24,25,26,27)/p+1/b2-1- MTLUWGRHGJBYAG-UPHRSURJSA-O 50627251 CHEMBL5420929 Eukaryotic translation initiation factor 4E Homo sapiens 1100 ChEMBL 10.1021/acs.jmedchem.3c00917 10.7270/Q2QN6C66 37471629 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627251&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 5T46,7XTP,7F07,7EZW,7D8B,7D6Y,5EKV,5EIR,5EI3,5EHC,4BEA,4AZA,3U7X,3TF2,2W97,2V8Y,2V8X,2V8W,2GPQ,1IPC,1IPB,4DUM,4DT6,5ZML,3AM7,1WKW,7MEU,8SX4,5ZK9,5ZK7,5ZK5,5ZJZ,5ZJY,4TQC,4TQB,4TPW Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51558368 Nc1nc2n(C\C=C/CP(O)(O)=O)c[n+](Cc3cc4cc(Cl)ccc4o3)c2c(=O)[nH]1 InChI=1S/C18H17ClN5O5P/c19-12-3-4-14-11(7-12)8-13(29-14)9-24-10-23(5-1-2-6-30(26,27)28)16-15(24)17(25)22-18(20)21-16/h1-4,7-8,10H,5-6,9H2,(H4-,20,21,22,25,26,27,28)/p+1/b2-1- FBIVWZVSDHRDAZ-UPHRSURJSA-O 50627252 CHEMBL5428127 Eukaryotic translation initiation factor 4E Homo sapiens 7700 ChEMBL 10.1021/acs.jmedchem.3c00917 10.7270/Q2QN6C66 37471629 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627252&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 5T46,7XTP,7F07,7EZW,7D8B,7D6Y,5EKV,5EIR,5EI3,5EHC,4BEA,4AZA,3U7X,3TF2,2W97,2V8Y,2V8X,2V8W,2GPQ,1IPC,1IPB,4DUM,4DT6,5ZML,3AM7,1WKW,7MEU,8SX4,5ZK9,5ZK7,5ZK5,5ZJZ,5ZJY,4TQC,4TQB,4TPW Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51558369 Nc1nc2n(C\C=C/CP(O)(O)=O)c[n+](Cc3cc4cc(Cl)ccc4s3)c2c(=O)[nH]1 InChI=1S/C18H17ClN5O4PS/c19-12-3-4-14-11(7-12)8-13(30-14)9-24-10-23(5-1-2-6-29(26,27)28)16-15(24)17(25)22-18(20)21-16/h1-4,7-8,10H,5-6,9H2,(H4-,20,21,22,25,26,27,28)/p+1/b2-1- ZZICBAZQGWIAIO-UPHRSURJSA-O 50627253 CHEMBL5414736 Eukaryotic translation initiation factor 4E Homo sapiens 16000 ChEMBL 10.1021/acs.jmedchem.3c00917 10.7270/Q2QN6C66 37471629 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627253&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 5T46,7XTP,7F07,7EZW,7D8B,7D6Y,5EKV,5EIR,5EI3,5EHC,4BEA,4AZA,3U7X,3TF2,2W97,2V8Y,2V8X,2V8W,2GPQ,1IPC,1IPB,4DUM,4DT6,5ZML,3AM7,1WKW,7MEU,8SX4,5ZK9,5ZK7,5ZK5,5ZJZ,5ZJY,4TQC,4TQB,4TPW Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51558370 Nc1nc2n(C\C=C/CP(O)(O)=O)c[n+](Cc3cn4cc(Cl)ccc4n3)c2c(=O)[nH]1 InChI=1S/C17H17ClN7O4P/c18-11-3-4-13-20-12(8-24(13)7-11)9-25-10-23(5-1-2-6-30(27,28)29)15-14(25)16(26)22-17(19)21-15/h1-4,7-8,10H,5-6,9H2,(H4-,19,21,22,26,27,28,29)/p+1/b2-1- USXCHHKBFUHEEM-UPHRSURJSA-O 50627254 CHEMBL5419734 Eukaryotic translation initiation factor 4E Homo sapiens 4000 ChEMBL 10.1021/acs.jmedchem.3c00917 10.7270/Q2QN6C66 37471629 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627254&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 5T46,7XTP,7F07,7EZW,7D8B,7D6Y,5EKV,5EIR,5EI3,5EHC,4BEA,4AZA,3U7X,3TF2,2W97,2V8Y,2V8X,2V8W,2GPQ,1IPC,1IPB,4DUM,4DT6,5ZML,3AM7,1WKW,7MEU,8SX4,5ZK9,5ZK7,5ZK5,5ZJZ,5ZJY,4TQC,4TQB,4TPW Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95 51558371 Nc1nc2n(C\C=C/CP(O)(O)=O)c[n+](Cc3cc4cc(Cl)ccc4[nH]3)c2c(=O)[nH]1 InChI=1S/C18H18ClN6O4P/c19-12-3-4-14-11(7-12)8-13(21-14)9-25-10-24(5-1-2-6-30(27,28)29)16-15(25)17(26)23-18(20)22-16/h1-4,7-8,10,21H,5-6,9H2,(H4-,20,22,23,26,27,28,29)/p+1/b2-1- JSTMWLOUXSFOCX-UPHRSURJSA-O 50627255 CHEMBL5424854 Eukaryotic translation initiation factor 4E Homo sapiens 5600 ChEMBL 10.1021/acs.jmedchem.3c00917 10.7270/Q2QN6C66 37471629 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7436&target=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627255&enzyme=Eukaryotic+translation+initiation+factor+4E&column=ki&startPg=0&Increment=50&submit=Search 1 MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV 5T46,7XTP,7F07,7EZW,7D8B,7D6Y,5EKV,5EIR,5EI3,5EHC,4BEA,4AZA,3U7X,3TF2,2W97,2V8Y,2V8X,2V8W,2GPQ,1IPC,1IPB,4DUM,4DT6,5ZML,3AM7,1WKW,7MEU,8SX4,5ZK9,5ZK7,5ZK5,5ZJZ,5ZJY,4TQC,4TQB,4TPW Eukaryotic translation initiation factor 4E IF4E_HUMAN P06730 B7Z6V1 D6RCQ6 Q96E95