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TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Affinity DataIC50:  79nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 60 mM K+-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Affinity DataIC50:  398nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of phenylephrine-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Affinity DataIC50:  481nMAssay Description:Inhibition of L-type calcium channel in Wistar rat aorta rings assessed as reduction in L-type Ba(2+) current at Vh of -50 mVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50280989(2,6-dimethyl-5-methyloxycarbonyl-4-(3-nitrophenyl)...)
Affinity DataIC50:  592nMAssay Description:Inhibition of [3H]PN-200-110 binding to L-type calcium channels in rat cortex membranes.More data for this Ligand-Target Pair
In DepthDetails Article

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50080302(2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...)
Affinity DataIC50:  900nMAssay Description:Inhibition of L-type calcium channels in GH-3 rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of L-type calcium channel in endothelium-intact Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50080296(2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of L-type calcium channels in GH-3 rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50085561(4-[2-(3-{2-[2-(3-Hydroxy-phenyl)-ethyl]-benzyloxy}...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of L-type [Ca2+] channel (VSCC) in rat A7r5 vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50080295(2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of L-type calcium channels in GH-3 rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50085560(4-[2-(3-{2-[2-(4-Hydroxy-phenyl)-ethyl]-benzyloxy}...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of L-type [Ca2+] channel (VSCC) in rat A7r5 vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50212319(CHEMBL18412)
Affinity DataIC50:  5.87E+3nMAssay Description:Displacement of [3H]nitrendipine from calcium channel receptorMore data for this Ligand-Target Pair
In DepthDetails

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50080299(2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...)
Affinity DataIC50:  9.10E+3nMAssay Description:Inhibition of L-type calcium channels in GH-3 rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50019968(7-Ethyl-1,3,5-trimethyl-6,7-dihydro-1H-1,2,4,5a,8-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]nitrendipine from L-type [Ca2+] channel of rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50046397(CHEMBL3314412)
Affinity DataIC50:  1.58E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 60 mM K+-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50046397(CHEMBL3314412)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of phenylephrine-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50046397(CHEMBL3314412)
Affinity DataIC50:  3.16E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50046397(CHEMBL3314412)
Affinity DataIC50:  3.98E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-intact Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50046399(CHEMBL3314413)
Affinity DataIC50:  5.01E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of phenylephrine-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50046399(CHEMBL3314413)
Affinity DataIC50:  6.31E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-intact Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50046399(CHEMBL3314413)
Affinity DataIC50:  7.94E+4nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 60 mM K+-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50046399(CHEMBL3314413)
Affinity DataIC50:  1.26E+5nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 30 mM K+-induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50046397(CHEMBL3314412)
Affinity DataIC50:  2.51E+5nMAssay Description:Inhibition of L-type calcium channel in Wistar rat aorta rings assessed as reduction in L-type Ba(2+) current at Vh of -50 mVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50230150(CHEMBL345052)
Affinity DataIC50: >5.00E+6nMAssay Description:Calcium channel binding activity against dihydropyridine receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50001689(4-(3-(4-benzhydrylpiperazin-1-yl)-2-hydroxypropoxy...)
Affinity DataIC50:  5.00E+6nMAssay Description:Calcium channel binding activity against dihydropyridine receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rat)
Vietnam Academy of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50230151(CHEMBL136313)
Affinity DataIC50: >5.00E+6nMAssay Description:Calcium channel binding activity against dihydropyridine receptor in rat brain cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed