Compile Data Set for Download or QSAR
Report error Found 136 of ic50 for UniProtKB: P35372
LigandPNGBDBM50225844(CHEMBL56347)
Affinity DataIC50: 0.0700nMAssay Description:Compound was tested for antagonistic activity against opioid receptor in electrically stimulated longitudinal muscle of guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50002346(CHEMBL384584 | [D-pro10]Dynorphin A(1-11))
Affinity DataIC50: 0.220nMAssay Description:Tested for opioid receptor agonistic activity in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50226283(CHEMBL172293)
Affinity DataIC50: 0.280nMAssay Description:In vitro inhibitory activity against opioid activity in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50123599(ETORPHINE)
Affinity DataIC50: 0.300nMAssay Description:Evaluated the ability to protect against the irreversible antagonism of morphines effects by beta-FNA in guinea pig ileal longitudinal muscle.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50013388(CHEMBL350384 | BREMAZOCINE(-) | 6-Ethyl-3-(1-hydro...)
Affinity DataIC50: 0.5nMAssay Description:In vitro binding affinity against Opioid receptors from bovine caudate nucleus determined in presence of [3H]- bremazocine (0.5 nM)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM60212(SMR000058767 | NALTREXONE HYDROCHLORIDE | MLS00006...)
Affinity DataIC50: 0.550nMAssay Description:Displacement of [3H] naloxone from opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50226282(CHEMBL170858)
Affinity DataIC50: 0.590nMAssay Description:In vitro inhibitory activity against opioid activity in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM60212(SMR000058767 | NALTREXONE HYDROCHLORIDE | MLS00006...)
Affinity DataIC50: 0.590nMAssay Description:Displacement of [3H] naloxone from opioid receptor (unknown origin) in presence of 100 mM NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50224554(Ethylketazocine)
Affinity DataIC50: 0.600nMAssay Description:Evaluated the ability to protect against the irreversible antagonism of morphines effects by beta-FNA in guinea pig ileal longitudinal muscle.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50497034(CHEMBL3249714)
Affinity DataIC50: 0.700nMAssay Description:Displacement of [3H] naloxone from opioid receptor (unknown origin) in presence of 100 mM NaClMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50497032(CHEMBL3249922)
Affinity DataIC50: 0.800nMAssay Description:Displacement of [3H]naloxone from opioid receptor (unknown origin) by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50497034(CHEMBL3249714)
Affinity DataIC50: 0.910nMAssay Description:Displacement of [3H] naloxone from opioid receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50010703(CHEMBL443068 | H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Cys-A...)
Affinity DataIC50: 1.30nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue of guinea pig ileum (GPI)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-13-ox...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of total opioid receptor by displacing 0.5 nM [3H]bremazocine in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50059841(CHEMBL278789 | (S)-1-[(S)-2-[2-((S)-2-{(R)-2-[(S)-...)
Affinity DataIC50: 1.40nMAssay Description:In vitro opioid inhibitory activity against in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50013388(CHEMBL350384 | BREMAZOCINE(-) | 6-Ethyl-3-(1-hydro...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of total opioid receptor by displacing 0.5 nM [3H]bremazocine in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50013388(CHEMBL350384 | BREMAZOCINE(-) | 6-Ethyl-3-(1-hydro...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of 0.5 nM [3H]bremazocine binding to guinea pig brain membrane opioid receptorsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50002184(Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Ly...)
Affinity DataIC50: 1.70nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue of guinea pig ileum (GPI)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50123599(ETORPHINE)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of total opioid receptor by displacing 0.5 nM [3H]bremazocine in guinea pig brain membraneMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50010701(CHEMBL410616 | H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D-Cys...)
Affinity DataIC50: 1.80nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue of guinea pig ileum (GPI)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50226284(CHEMBL170091)
Affinity DataIC50: 2.10nMAssay Description:In vitro inhibitory activity against opioid activity in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50455774(CHEMBL2092986)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of total opioid receptor by displacing 0.5 nM [3H]bremazocine in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50002347(CHEMBL425806 | [N-cyclopropyl methylTyr1, D-pro10]...)
Affinity DataIC50: 2.20nMAssay Description:Tested for opioid receptor agonistic activity in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50010706(CHEMBL384250 | H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D-Cys...)
Affinity DataIC50: 2.30nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue of guinea pig ileum (GPI)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50001713(CHEMBL143815 | methyl 2-[19-(1-hydroxy-1-methylbut...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of total opioid receptor by displacing 0.5 nM [3H]bremazocine in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50013385(CHEMBL166355 | methyl 2-[4-cyclopropylmethyl-10,17...)
Affinity DataIC50: 2.40nMAssay Description:In vitro binding affinity against Opioid receptors from bovine caudate nucleus determined in presence of [3H]- bremazocine (0.5 nM)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50010702(Dynorphin A (1-17) | dynorphin A | DYNORPHIN(1-17)...)
Affinity DataIC50: 2.5nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue of guinea pig ileum (GPI)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataIC50: 2.60nMAssay Description:Tested for opioid receptor agonistic activity in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50226289(CHEMBL369354)
Affinity DataIC50: 2.70nMAssay Description:In vitro opioid inhibitory activity against in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50497036(CHEMBL3249715)
Affinity DataIC50: 2.90nMAssay Description:Displacement of [3H] naloxone from opioid receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50226286(CHEMBL296148)
Affinity DataIC50: 3nMAssay Description:In vitro opioid inhibitory activity against in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50225843(CHEMBL293990)
Affinity DataIC50: 3.80nMAssay Description:Compound was tested for agonist activity against opioid receptor in electrically stimulated longitudinal muscle of guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM54795((4R,4aS,7aR,12bS)-4a,9-bis(oxidanyl)-3-prop-2-enyl...)
Affinity DataIC50: 4.30nMAssay Description:Displacement of [3H] naloxone from opioid receptor (unknown origin) in presence of 100 mM NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50013387(CHEMBL163704 | 4-cyclopropylmethyl-10,17-dihydroxy...)
Affinity DataIC50: 5nMAssay Description:In vitro binding affinity against Opioid receptors from bovine caudate nucleus determined in presence of [3H]- bremazocine (0.5 nM)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50497120(CHEMBL3274598)
Affinity DataIC50: 5.30nMAssay Description:Displacement of [3H]naloxone from opiate receptor (unknown origin) after 10 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM54795((4R,4aS,7aR,12bS)-4a,9-bis(oxidanyl)-3-prop-2-enyl...)
Affinity DataIC50: 5.5nMAssay Description:Displacement of [3H] naloxone from opioid receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataIC50: 5.5nMAssay Description:Displacement of [3H]naloxone from opiate receptor (unknown origin) after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM60212(SMR000058767 | NALTREXONE HYDROCHLORIDE | MLS00006...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of total opioid receptor by displacing 0.5 nM [3H]bremazocine in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM60212(SMR000058767 | NALTREXONE HYDROCHLORIDE | MLS00006...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of 0.5 nM [3H]bremazocine binding to guinea pig brain membrane opioid receptorsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50000091(EKC | EKC(-) | CHEMBL279968 | 3-Cyclopropylmethyl-...)
Affinity DataIC50: 5.90nMAssay Description:In vitro inhibitory activity against opioid receptor in Guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50013386(4-cyclopropylmethyl-10,17-dihydroxy-12-oxa-4-azape...)
Affinity DataIC50: 6nMAssay Description:In vitro binding affinity against Opioid receptors from bovine caudate nucleus determined in presence of [3H]- bremazocine (0.5 nM)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50010704(Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Ly...)
Affinity DataIC50: 7.5nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue of guinea pig ileum (GPI)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50497036(CHEMBL3249715)
Affinity DataIC50: 9nMAssay Description:Displacement of [3H] naloxone from opioid receptor (unknown origin) in presence of 100 mM NaClMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM50071860(12-(2-Amino-3-phenyl-propionylamino)-9-benzyl-5,5-...)
Affinity DataIC50: 9.10nMAssay Description:Agonistic activity tested in vitro in guinea pig ileum opioidMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50000092(Analog of 14-(Arylhydroxyamino)codeinone | 4-methy...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Opioid receptors with [3H]naloxone binding in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50001705(CHEMBL343167 | methyl 2-[4-cyclopropylmethyl-17-hy...)
Affinity DataIC50: 10nMAssay Description:Inhibition of total opioid receptor by displacing 0.5 nM [3H]bremazocine in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50000790(CHEMBL76023 | methyl 2-[4-cyclopropylmethyl-10,17-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of total opioid receptor by displacing 0.5 nM [3H]bremazocine in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM82551(C18130 | CAS_105618-26-6 | NORBNI | NOR-BNI (HCI)2)
Affinity DataIC50: 11nMAssay Description:Inhibition of total opioid receptor by displacing 0.5 nM [3H]bremazocine in guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50000790(CHEMBL76023 | methyl 2-[4-cyclopropylmethyl-10,17-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of 0.5 nM [3H]bremazocine binding to guinea pig brain membrane opioid receptorsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50000793(CHEMBL311912 | 4-cyclopropylmethyl-14-(2-oxiranylm...)
Affinity DataIC50: 11nMAssay Description:Inhibition of 0.5 nM [3H]bremazocine binding to guinea pig brain membrane opioid receptorsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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