Compile Data Set for Download or QSAR
Found 15 of ki for UniProtKB: P14416
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50005118((S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(Cl)c1OC
Show InChI InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1
Affinity DataKi:  5.10nMAssay Description:In vitro inhibition of [3H]-Spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranes (using L-tartrate salt of authentic rac...More data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50005118((S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(Cl)c1OC
Show InChI InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1
Affinity DataKi:  8.70nMAssay Description:In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50228777(CHEMBL80127)
Show SMILES CCCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(Cl)c1OC
Show InChI InChI=1S/C16H22Cl2N2O3/c1-3-6-20-7-4-5-10(20)9-19-16(22)13-14(21)11(17)8-12(18)15(13)23-2/h8,10,21H,3-7,9H2,1-2H3,(H,19,22)/t10-/m0/s1
Affinity DataKi:  17nMAssay Description:In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50228772(CHEMBL418922)
Show SMILES CCCCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(Cl)c1OC
Show InChI InChI=1S/C17H24Cl2N2O3/c1-3-4-7-21-8-5-6-11(21)10-20-17(23)14-15(22)12(18)9-13(19)16(14)24-2/h9,11,22H,3-8,10H2,1-2H3,(H,20,23)/t11-/m0/s1
Affinity DataKi:  41nMAssay Description:In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50228774(CHEMBL80126)
Show SMILES COc1c(Cl)cc(Cl)c(O)c1C(=O)NC[C@@H]1CCCN1CCCCF
Show InChI InChI=1S/C17H23Cl2FN2O3/c1-25-16-13(19)9-12(18)15(23)14(16)17(24)21-10-11-5-4-8-22(11)7-3-2-6-20/h9,11,23H,2-8,10H2,1H3,(H,21,24)/t11-/m0/s1
Affinity DataKi:  89nMAssay Description:In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50134526(2-{2-[5-(2-Benzyloxy-phenyl)-thiophen-3-yl]-phenyl...)
Show SMILES OC(=O)C1CC1c1ccccc1-c1csc(c1)-c1ccccc1OCc1ccccc1
Show InChI InChI=1S/C27H22O3S/c28-27(29)24-15-23(24)21-11-5-4-10-20(21)19-14-26(31-17-19)22-12-6-7-13-25(22)30-16-18-8-2-1-3-9-18/h1-14,17,23-24H,15-16H2,(H,28,29)
Affinity DataKi:  120nMAssay Description:Ability to inhibit the binding of human DP receptor to PGD-2More data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50228776(CHEMBL81778)
Show SMILES COc1c(Cl)cc(Cl)c(O)c1C(=O)NC[C@@H]1CCCN1CCCF
Show InChI InChI=1S/C16H21Cl2FN2O3/c1-24-15-12(18)8-11(17)14(22)13(15)16(23)20-9-10-4-2-6-21(10)7-3-5-19/h8,10,22H,2-7,9H2,1H3,(H,20,23)/t10-/m0/s1
Affinity DataKi:  130nMAssay Description:In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50228771(CHEMBL312602)
Show SMILES COc1c(Cl)cc(Cl)c(O)c1C(=O)NC[C@@H]1CCCN1CCF
Show InChI InChI=1S/C15H19Cl2FN2O3/c1-23-14-11(17)7-10(16)13(21)12(14)15(22)19-8-9-3-2-5-20(9)6-4-18/h7,9,21H,2-6,8H2,1H3,(H,19,22)/t9-/m0/s1
Affinity DataKi:  159nMAssay Description:In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50159788(CHEMBL3786973)
Show SMILES CCN\C(=N/S(=O)(=O)c1ccc(N)cc1)N1CC2(CCCC2)C=N1
Show InChI InChI=1S/C16H23N5O2S/c1-2-18-15(21-12-16(11-19-21)9-3-4-10-16)20-24(22,23)14-7-5-13(17)6-8-14/h5-8,11H,2-4,9-10,12,17H2,1H3,(H,18,20)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to dopamine receptor (unknown origin)More data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50187377(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)
Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1
Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28)
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to dopamine receptor by radioligand binding assayMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50228775(CHEMBL77448)
Show SMILES COc1c(Cl)cc(Cl)c(O)c1C(=O)NC[C@@H]1CCCN1CCC(C)F
Show InChI InChI=1S/C17H23Cl2FN2O3/c1-10(20)5-7-22-6-3-4-11(22)9-21-17(24)14-15(23)12(18)8-13(19)16(14)25-2/h8,10-11,23H,3-7,9H2,1-2H3,(H,21,24)/t10?,11-/m0/s1
Affinity DataKi:  2.61E+3nMAssay Description:In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50228773(CHEMBL2021339)
Show SMILES COc1c(Cl)cc(Cl)c(O)c1C(=O)NC[C@H]1CCCN1CCC(C)F
Show InChI InChI=1S/C17H23Cl2FN2O3/c1-10(20)5-7-22-6-3-4-11(22)9-21-17(24)14-15(23)12(18)8-13(19)16(14)25-2/h8,10-11,23H,3-7,9H2,1-2H3,(H,21,24)/t10?,11-/m1/s1
Affinity DataKi:  2.62E+3nMAssay Description:In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in Macaca nemestrina striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50132104(6-Methoxy-1-methyl-4,9-dihydro-3H-beta-carboline |...)
Show SMILES COc1ccc2[nH]c3c(CCN=C3C)c2c1
Show InChI InChI=1S/C13H14N2O/c1-8-13-10(5-6-14-8)11-7-9(16-2)3-4-12(11)15-13/h3-4,7,15H,5-6H2,1-2H3
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards cloned rat 5-hydroxytryptamine 2A receptor by [3H]-ketanserin displacement.More data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Show SMILES COc1ccc2c(c1)[nH]c1c(C)nccc21
Show InChI InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards cloned rat 5-hydroxytryptamine 2A receptor by [3H]-ketanserin displacement.More data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50136493(1-Methyl-4,9-dihydro-3H-beta-carboline | 1-methyl-...)
Show SMILES CC1=NCCc2c1[nH]c1ccccc21
Show InChI InChI=1S/C12H12N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-5,14H,6-7H2,1H3
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards cloned rat Inhibition of binding towards 5-hydroxytryptamine 2A receptor at 100 nM concentration was determined using [3H]-D...More data for this Ligand-Target Pair