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Report error Found 66 of ic50 for UniProtKB: P42866
LigandPNGBDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)
Affinity DataIC50:  0.360nMAssay Description:Compound was tested for antagonistic activity against opioid receptor in mouse vas deferensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50369571(CHEMBL1790710)
Affinity DataIC50:  2.70nMAssay Description:Opioid receptor activity was evaluated using mouse vas deferens (MVD) assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001683(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Affinity DataIC50:  2.80nMAssay Description:Compound was tested for agonistic activity against the opioid receptor in electrically stimulated mouse vas deference.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225846(CHEMBL293145)
Affinity DataIC50:  7nMAssay Description:Compound was tested for agonist activity against opioid receptor in mouse vas deferens preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50002184(CHEMBL415330 | H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-A...)
Affinity DataIC50:  7.80nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue mouse vas deferens (MVD)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataIC50:  8.40nMAssay Description:Concentration required to inhibit the specific binding of tritiated ligand [3H]DADL to opiate receptor by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM21025((2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydro...)
Affinity DataIC50:  9nMAssay Description:Concentration required to inhibit the specific binding of tritiated ligand [3H]DADL to opiate receptor by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225254(CHEMBL610531)
Affinity DataIC50:  12.5nMAssay Description:In vitro binding affinity against opioid receptor using 1 nM [3H]- Naltrexone in the presence of 100 mM NaCl.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225254(CHEMBL610531)
Affinity DataIC50:  13nMAssay Description:In vitro binding affinity against opioid receptor using 1 nM [3H]- Naltrexone in the presence of 100 mM NaCl.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225849(CHEMBL301654)
Affinity DataIC50:  13nMAssay Description:Compound was tested for agonist activity against opioid receptor in mouse vas deferens preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225254(CHEMBL610531)
Affinity DataIC50:  15nMAssay Description:In vitro binding affinity against opioid receptor using 1 nM of [3H]- Naltrexone in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225254(CHEMBL610531)
Affinity DataIC50:  15nMAssay Description:In vitro binding affinity against opioid receptor using 1 nM of [3H]- Naltrexone in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50010701(CHEMBL410616 | H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D-Cys...)
Affinity DataIC50:  20nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue mouse vas deferens (MVD)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50010703(CHEMBL443068 | H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Cys-A...)
Affinity DataIC50:  20nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue mouse vas deferens (MVD)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225847(CHEMBL54820)
Affinity DataIC50:  21nMAssay Description:Compound was tested for agonist activity against opioid receptor in mouse vas deferens preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50010702(CHEMBL411557 | DYNORPHIN(1-17)-OH | Dynorphin A (1...)
Affinity DataIC50:  23nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue mouse vas deferens (MVD)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50010706(CHEMBL384250 | H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D-Cys...)
Affinity DataIC50:  25nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue mouse vas deferens (MVD)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataIC50:  27nMAssay Description:Concentration required to inhibit [3H]naltrexone binding to Opioid receptorsMore data for this Ligand-Target Pair
LigandPNGBDBM50231235(CHEMBL441636)
Affinity DataIC50:  30nMAssay Description:Tested for displacement of radioligand [3H]-Naloxone from opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231227(CHEMBL328583)
Affinity DataIC50:  55nMAssay Description:Tested for displacement of radioligand [3H]-Naloxone from opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50367061(NALORPHINE | NALORPHINE HYDROCHLORIDE)
Affinity DataIC50:  59nMAssay Description:Concentration required to inhibit the stereospecific [3H]diprenorphine binding Opioid receptors in the absence of sodium(Na+) was determined in mouse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225845(CHEMBL293967)
Affinity DataIC50:  70nMAssay Description:Compound was tested for agonist activity against opioid receptor in mouse vas deferens preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataIC50:  75nMAssay Description:Concentration required to inhibit the specific binding of tritiated ligand [3H]-naloxone to opiate receptor by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50247803(Beta-Funeltrexamine | CHEMBL473136 | beta-funaltre...)
Affinity DataIC50:  82nMAssay Description:Compound was tested for agonist activity against opioid receptor in mouse vas deferens preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001674(14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04...)
Affinity DataIC50:  85nMAssay Description:Compound was tested for agonistic activity against the opioid receptor in electrically stimulated mouse vas deferenceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225255(CHEMBL2310924)
Affinity DataIC50:  115nMAssay Description:In vitro binding affinity against opioid receptor using 1 nM of [3H]- Naltrexone in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225255(CHEMBL2310924)
Affinity DataIC50:  115nMAssay Description:In vitro binding affinity against opioid receptor using 1 nM of [3H]- Naltrexone in the absence of NaClMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001675(14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04...)
Affinity DataIC50:  124nMAssay Description:Compound was tested for agonistic activity against the opioid receptor in electrically stimulated mouse vas deferenceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231230(CHEMBL328019)
Affinity DataIC50:  150nMAssay Description:Tested for displacement of radioligand [3H]-Naloxone from opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50367061(NALORPHINE | NALORPHINE HYDROCHLORIDE)
Affinity DataIC50:  160nMAssay Description:Concentration required to inhibit the stereospecific [3H]diprenorphine binding Opioid receptors in the presence of sodium(Na+) was determined in mous...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001679(22-phenethyl-14-oxa-11,22-diazaheptacyclo[13.9.1.0...)
Affinity DataIC50:  171nMAssay Description:Compound was tested for agonistic activity against the opioid receptor in electrically stimulated mouse vas deferenceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001677(22-phenethyl-14-oxa-11,22-diazaheptacyclo[13.9.1.0...)
Affinity DataIC50:  179nMAssay Description:Compound was tested for agonistic activity against the opioid receptor in electrically stimulated mouse vas deferenceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231233(CHEMBL92960)
Affinity DataIC50:  200nMAssay Description:Tested for displacement of radioligand [3H]-Naloxone from opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50010704(CHEMBL216640 | Dyn A(1-11)-NH2 | Dynorphin A analo...)
Affinity DataIC50:  204nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue mouse vas deferens (MVD)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataIC50:  258nMAssay Description:Opioid receptor activity was evaluated using mouse vas deferens (MVD) assayMore data for this Ligand-Target Pair
LigandPNGBDBM50231240(CHEMBL92779)
Affinity DataIC50:  400nMAssay Description:Tested for displacement of radioligand [3H]-Naloxone from opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50010705(CHEMBL385759 | H-Tyr-Gly-Gly-Phe-Cys-Arg-Arg-Ile-A...)
Affinity DataIC50:  421nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue mouse vas deferens (MVD)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50026752(1-Methyl-4-phenyl-piperidine-4-carboxylic acid eth...)
Affinity DataIC50:  500nMAssay Description:Tested for displacement of radioligand [3H]-Naloxone from opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225255(CHEMBL2310924)
Affinity DataIC50:  880nMAssay Description:In vitro binding affinity against opioid receptor using 1 nM [3H]- Naltrexone in the presence of 100 mM NaCl.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225255(CHEMBL2310924)
Affinity DataIC50:  880nMAssay Description:In vitro binding affinity against opioid receptor using 1 nM [3H]- Naltrexone in the presence of 100 mM NaCl.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231231(CHEMBL92124)
Affinity DataIC50:  900nMAssay Description:Tested for displacement of radioligand [3H]-Naloxone from opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50010700(CHEMBL265824 | H-Tyr-Gly-Gly-Phe-Cys-Arg-Arg-D-Ala...)
Affinity DataIC50:  1.66E+3nMAssay Description:Opioid receptors antagonist activity in smooth-muscle tissue mouse vas deferens (MVD)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003560(4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.0...)
Affinity DataIC50:  2.00E+3nMAssay Description:Concentration required to inhibit [3H]naltrexone binding to Opioid receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223879(CHEMBL280688)
Affinity DataIC50:  3.00E+3nMAssay Description:Concentration required to inhibit [3H]naltrexone binding to Opioid receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231236(CHEMBL89961)
Affinity DataIC50:  4.00E+3nMAssay Description:Tested for displacement of radioligand [3H]-Naloxone from opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017233(CHEMBL592 | LEVO-DROMORAN | LEVORPHANOL)
Affinity DataIC50:  4.00E+3nMAssay Description:Concentration required to inhibit [3H]naltrexone binding to Opioid receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231241(CHEMBL285244)
Affinity DataIC50:  5.00E+3nMAssay Description:Tested for displacement of radioligand [3H]-Naloxone from opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231237(CHEBI:6125 | Cetobemidone | Cliradon | Cymidon | K...)
Affinity DataIC50:  7.00E+3nMAssay Description:Tested for displacement of radioligand [3H]-Naloxone from opiate receptor; value ranges from 7-10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50231228(CHEMBL96626)
Affinity DataIC50:  8.00E+3nMAssay Description:Displacement of radioligand [3H]-2-(di-N-propylamino)-8-hydroxytetralin from 5-hydroxytryptamine 1A receptor in rat frontal cortex homogenate (experi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223880(CHEMBL610906)
Affinity DataIC50:  8.50E+3nMAssay Description:Concentration required to inhibit the stereospecific [3H]diprenorphine binding Opioid receptors in the absence of sodium(Na+) was determined in mouse...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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