Compile Data Set for Download or QSAR
Found 26 of ec50 for UniProtKB: P19793
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551946(CHEMBL4764328)
Show SMILES CC(C)(C)CC(=O)N1CC[C@@]2([C@H]1c1cccc(c1)-c1ccc(CO)c(c1)S(C)(=O)=O)C(=O)Nc1ccccc21
Show InChI InChI=1S/C31H34N2O5S/c1-30(2,3)18-27(35)33-15-14-31(24-10-5-6-11-25(24)32-29(31)36)28(33)22-9-7-8-20(16-22)21-12-13-23(19-34)26(17-21)39(4,37)38/h5-13,16-17,28,34H,14-15,18-19H2,1-4H3,(H,32,36)/t28-,31-/m1/s1
Affinity DataEC50:  0.0160nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551956(CHEMBL4756418)
Show SMILES CC(C)(C)OC(=O)N1CC[C@@]2([C@H]1c1cccc(c1)-c1ccc(CO)c(c1)S(C)(=O)=O)C(=O)Nc1ccccc21
Show InChI InChI=1S/C30H32N2O6S/c1-29(2,3)38-28(35)32-15-14-30(23-10-5-6-11-24(23)31-27(30)34)26(32)21-9-7-8-19(16-21)20-12-13-22(18-33)25(17-20)39(4,36)37/h5-13,16-17,26,33H,14-15,18H2,1-4H3,(H,31,34)/t26-,30-/m1/s1
Affinity DataEC50:  0.0350nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551953(CHEMBL4764838)
Show SMILES COC(=O)c1ccc(cc1S(C)(=O)=O)-c1cccc(c1)[C@H]1N(CC[C@]11C(=O)Nc2ccccc12)C(=O)OC(C)(C)C
Show InChI InChI=1S/C31H32N2O7S/c1-30(2,3)40-29(36)33-16-15-31(23-11-6-7-12-24(23)32-28(31)35)26(33)21-10-8-9-19(17-21)20-13-14-22(27(34)39-4)25(18-20)41(5,37)38/h6-14,17-18,26H,15-16H2,1-5H3,(H,32,35)/t26-,31-/m1/s1
Affinity DataEC50:  0.0520nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551945(CHEMBL4747448)
Show SMILES CC(C)(C)CC(=O)N1CCC2(C1c1cccc(c1)-c1ccc(CO)c(c1)S(C)(=O)=O)C(=O)Nc1ccccc21
Show InChI InChI=1S/C31H34N2O5S/c1-30(2,3)18-27(35)33-15-14-31(24-10-5-6-11-25(24)32-29(31)36)28(33)22-9-7-8-20(16-22)21-12-13-23(19-34)26(17-21)39(4,37)38/h5-13,16-17,28,34H,14-15,18-19H2,1-4H3,(H,32,36)
Affinity DataEC50:  0.0670nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551964(CHEMBL4745005)
Show SMILES CC(C)(C)CC(=O)N1CC[C@]2([C@@H]1c1cccc(c1)-c1ccc(CO)c(c1)S(C)(=O)=O)C(=O)Nc1ccccc21
Show InChI InChI=1S/C31H34N2O5S/c1-30(2,3)18-27(35)33-15-14-31(24-10-5-6-11-25(24)32-29(31)36)28(33)22-9-7-8-20(16-22)21-12-13-23(19-34)26(17-21)39(4,37)38/h5-13,16-17,28,34H,14-15,18-19H2,1-4H3,(H,32,36)/t28-,31-/m0/s1
Affinity DataEC50:  0.0830nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551947(CHEMBL4797369)
Show SMILES CC(C)(C)OC(=O)N1CC[C@@]2([C@H]1c1cccc(Nc3ccc(CO)c(c3)S(C)(=O)=O)c1)C(=O)Nc1ccccc21
Show InChI InChI=1S/C30H33N3O6S/c1-29(2,3)39-28(36)33-15-14-30(23-10-5-6-11-24(23)32-27(30)35)26(33)19-8-7-9-21(16-19)31-22-13-12-20(18-34)25(17-22)40(4,37)38/h5-13,16-17,26,31,34H,14-15,18H2,1-4H3,(H,32,35)/t26-,30-/m1/s1
Affinity DataEC50:  0.0880nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551950(CHEMBL4757761)
Show SMILES CC(C)(C)OC(=O)N1CC[C@@]2([C@H]1c1cccc(c1)-c1cc(F)c(CO)c(c1)S(C)(=O)=O)C(=O)Nc1ccccc21
Show InChI InChI=1S/C30H31FN2O6S/c1-29(2,3)39-28(36)33-13-12-30(22-10-5-6-11-24(22)32-27(30)35)26(33)19-9-7-8-18(14-19)20-15-23(31)21(17-34)25(16-20)40(4,37)38/h5-11,14-16,26,34H,12-13,17H2,1-4H3,(H,32,35)/t26-,30-/m1/s1
Affinity DataEC50:  0.0920nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551948(CHEMBL4760781)
Show SMILES CC(C)(C)OC(=O)N1CCC2(C1c1cccc(Nc3ccc(CO)c(c3)S(C)(=O)=O)c1)C(=O)Nc1ccccc21
Show InChI InChI=1S/C30H33N3O6S/c1-29(2,3)39-28(36)33-15-14-30(23-10-5-6-11-24(23)32-27(30)35)26(33)19-8-7-9-21(16-19)31-22-13-12-20(18-34)25(17-22)40(4,37)38/h5-13,16-17,26,31,34H,14-15,18H2,1-4H3,(H,32,35)
Affinity DataEC50:  0.0950nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551951(CHEMBL4749385)
Show SMILES CC(C)(C)OC(=O)N1CCC2(C1c1cccc(c1)-c1cc(F)c(CO)c(c1)S(C)(=O)=O)C(=O)Nc1ccccc21
Show InChI InChI=1S/C30H31FN2O6S/c1-29(2,3)39-28(36)33-13-12-30(22-10-5-6-11-24(22)32-27(30)35)26(33)19-9-7-8-18(14-19)20-15-23(31)21(17-34)25(16-20)40(4,37)38/h5-11,14-16,26,34H,12-13,17H2,1-4H3,(H,32,35)
Affinity DataEC50:  0.103nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM19993(CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...)
Show SMILES OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
Affinity DataEC50:  0.108nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551957(CHEMBL4755317)
Show SMILES CC(C)(C)OC(=O)N1CCC2(C1c1cccc(c1)-c1ccc(CO)c(c1)S(C)(=O)=O)C(=O)Nc1ccccc21
Show InChI InChI=1S/C30H32N2O6S/c1-29(2,3)38-28(35)32-15-14-30(23-10-5-6-11-24(23)31-27(30)34)26(32)21-9-7-8-19(16-21)20-12-13-22(18-33)25(17-20)39(4,36)37/h5-13,16-17,26,33H,14-15,18H2,1-4H3,(H,31,34)
Affinity DataEC50:  0.174nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM26066(2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophe...)
Show SMILES Fc1ccc(cc1)-c1n(Cc2ccc(F)cc2Cl)nc2c(cccc12)C(F)(F)F
Show InChI InChI=1S/C21H12ClF5N2/c22-18-10-15(24)9-6-13(18)11-29-20(12-4-7-14(23)8-5-12)16-2-1-3-17(19(16)28-29)21(25,26)27/h1-10H,11H2
Affinity DataEC50:  0.212nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM19992(2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methy...)
Show SMILES OC(=O)Cc1cccc(OCCCN(CC(c2ccccc2)c2ccccc2)Cc2cccc(c2Cl)C(F)(F)F)c1
Show InChI InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40)
Affinity DataEC50:  0.228nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551949(CHEMBL4762546)
Show SMILES CC(C)(C)OC(=O)N1CC[C@]2([C@@H]1c1cccc(c1)-c1cc(F)c(CO)c(c1)S(C)(=O)=O)C(=O)Nc1ccccc21
Show InChI InChI=1S/C30H31FN2O6S/c1-29(2,3)39-28(36)33-13-12-30(22-10-5-6-11-24(22)32-27(30)35)26(33)19-9-7-8-18(14-19)20-15-23(31)21(17-34)25(16-20)40(4,37)38/h5-11,14-16,26,34H,12-13,17H2,1-4H3,(H,32,35)/t26-,30-/m0/s1
Affinity DataEC50:  0.281nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551954(CHEMBL4757158)
Show SMILES COC(=O)c1ccc(cc1S(C)(=O)=O)-c1cccc(c1)C1N(CCC11C(=O)Nc2ccccc12)C(=O)OC(C)(C)C
Show InChI InChI=1S/C31H32N2O7S/c1-30(2,3)40-29(36)33-16-15-31(23-11-6-7-12-24(23)32-28(31)35)26(33)21-10-8-9-19(17-21)20-13-14-22(27(34)39-4)25(18-20)41(5,37)38/h6-14,17-18,26H,15-16H2,1-5H3,(H,32,35)
Affinity DataEC50:  0.341nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551963(CHEMBL4764539)
Show SMILES CN(C)C(=O)c1ccc(cc1Cl)-c1cccc(c1)[C@H]1N(CC[C@]11C(=O)Nc2ccccc12)C(=O)OC(C)(C)C
Show InChI InChI=1S/C31H32ClN3O4/c1-30(2,3)39-29(38)35-16-15-31(23-11-6-7-12-25(23)33-28(31)37)26(35)21-10-8-9-19(17-21)20-13-14-22(24(32)18-20)27(36)34(4)5/h6-14,17-18,26H,15-16H2,1-5H3,(H,33,37)/t26-,31-/m1/s1
Affinity DataEC50:  0.369nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551955(CHEMBL4777240)
Show SMILES CC(C)(C)OC(=O)N1CC[C@]2([C@@H]1c1cccc(c1)-c1ccc(CO)c(c1)S(C)(=O)=O)C(=O)Nc1ccccc21
Show InChI InChI=1S/C30H32N2O6S/c1-29(2,3)38-28(35)32-15-14-30(23-10-5-6-11-24(23)31-27(30)34)26(32)21-9-7-8-19(16-21)20-12-13-22(18-33)25(17-20)39(4,36)37/h5-13,16-17,26,33H,14-15,18H2,1-4H3,(H,31,34)/t26-,30-/m0/s1
Affinity DataEC50:  0.430nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551962(CHEMBL4781683)
Show SMILES CC(C)(C)OC(=O)N1CC[C@@]2([C@H]1c1cccc(c1)-c1ccc(CO)cc1)C(=O)Nc1ccccc21
Show InChI InChI=1S/C29H30N2O4/c1-28(2,3)35-27(34)31-16-15-29(23-9-4-5-10-24(23)30-26(29)33)25(31)22-8-6-7-21(17-22)20-13-11-19(18-32)12-14-20/h4-14,17,25,32H,15-16,18H2,1-3H3,(H,30,33)/t25-,29-/m1/s1
Affinity DataEC50:  0.445nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551944(CHEMBL4748480)
Show SMILES CC(C)(C)OC(=O)N1CC[C@]2([C@@H]1c1cccc(Nc3ccc(CO)c(c3)S(C)(=O)=O)c1)C(=O)Nc1ccccc21
Show InChI InChI=1S/C30H33N3O6S/c1-29(2,3)39-28(36)33-15-14-30(23-10-5-6-11-24(23)32-27(30)35)26(33)19-8-7-9-21(16-19)31-22-13-12-20(18-34)25(17-22)40(4,37)38/h5-13,16-17,26,31,34H,14-15,18H2,1-4H3,(H,32,35)/t26-,30-/m0/s1
Affinity DataEC50:  0.474nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551961(CHEMBL4791199)
Show SMILES CC(C)(C)OC(=O)N1CC[C@]2([C@@H]1c1cccc(c1)-c1ccccc1)C(=O)Nc1ccccc21
Show InChI InChI=1S/C28H28N2O3/c1-27(2,3)33-26(32)30-17-16-28(22-14-7-8-15-23(22)29-25(28)31)24(30)21-13-9-12-20(18-21)19-10-5-4-6-11-19/h4-15,18,24H,16-17H2,1-3H3,(H,29,31)/t24-,28-/m0/s1
Affinity DataEC50:  0.632nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551958(CHEMBL4780872)
Show SMILES CC(C)(C)OC(=O)N1CC[C@@]2([C@H]1c1cccc(c1)-c1cccc(c1)S(C)(=O)=O)C(=O)Nc1ccccc21
Show InChI InChI=1S/C29H30N2O5S/c1-28(2,3)36-27(33)31-16-15-29(23-13-5-6-14-24(23)30-26(29)32)25(31)21-11-7-9-19(17-21)20-10-8-12-22(18-20)37(4,34)35/h5-14,17-18,25H,15-16H2,1-4H3,(H,30,32)/t25-,29-/m1/s1
Affinity DataEC50:  0.680nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551952(CHEMBL4762542)
Show SMILES COC(=O)c1ccc(cc1S(C)(=O)=O)-c1cccc(c1)[C@@H]1N(CC[C@@]11C(=O)Nc2ccccc12)C(=O)OC(C)(C)C
Show InChI InChI=1S/C31H32N2O7S/c1-30(2,3)40-29(36)33-16-15-31(23-11-6-7-12-24(23)32-28(31)35)26(33)21-10-8-9-19(17-21)20-13-14-22(27(34)39-4)25(18-20)41(5,37)38/h6-14,17-18,26H,15-16H2,1-5H3,(H,32,35)/t26-,31-/m0/s1
Affinity DataEC50:  0.905nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551959(CHEMBL4759393)
Show SMILES CC(C)(C)OC(=O)N1CCC2(C1c1cccc(c1)-c1ccccc1)C(=O)Nc1ccccc21
Show InChI InChI=1S/C28H28N2O3/c1-27(2,3)33-26(32)30-17-16-28(22-14-7-8-15-23(22)29-25(28)31)24(30)21-13-9-12-20(18-21)19-10-5-4-6-11-19/h4-15,18,24H,16-17H2,1-3H3,(H,29,31)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50551960(CHEMBL4791235)
Show SMILES CC(C)(C)OC(=O)N1CC[C@@]2([C@H]1c1cccc(c1)-c1ccccc1)C(=O)Nc1ccccc21
Show InChI InChI=1S/C28H28N2O3/c1-27(2,3)33-26(32)30-17-16-28(22-14-7-8-15-23(22)29-25(28)31)24(30)21-13-9-12-20(18-21)19-10-5-4-6-11-19/h4-15,18,24H,16-17H2,1-3H3,(H,29,31)/t24-,28-/m1/s1
Affinity DataEC50: >10nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50294737(3-Benzyl-4-{3-[(1-methyl-1H-indol-7-yl)methoxy]-ph...)
Show SMILES Cn1ccc2cccc(COc3cccc(c3)-c3c(Cc4ccccc4)cnc4c(cccc34)C(F)(F)F)c12
Show InChI InChI=1S/C33H25F3N2O/c1-38-17-16-23-10-5-12-25(32(23)38)21-39-27-13-6-11-24(19-27)30-26(18-22-8-3-2-4-9-22)20-37-31-28(30)14-7-15-29(31)33(34,35)36/h2-17,19-20H,18,21H2,1H3
Affinity DataEC50:  2.67E+3nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetOxysterols receptor LXR-beta/Retinoic acid receptor RXR-alpha(Homo sapiens (Human))
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50305074(4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8-(trifluo...)
Show SMILES CS(=O)(=O)c1cccc(Oc2cccc(c2)-c2ccnc3c(cccc23)C(F)(F)F)c1
Show InChI InChI=1S/C23H16F3NO3S/c1-31(28,29)18-8-3-7-17(14-18)30-16-6-2-5-15(13-16)19-11-12-27-22-20(19)9-4-10-21(22)23(24,25)26/h2-14H,1H3
Affinity DataEC50:  2.94E+3nMAssay Description:Agonist activity at human RXRalpha/LXRbeta expressed in HEK293 cells measured after 20 hrs by dual luciferase reporter gene assayMore data for this Ligand-Target Pair