Found 57 of ec50 for monomerid = 50000092 TargetAlpha-2A adrenergic/Mu-type opioid receptor(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataEC50: 3nMAssay Description:Inhibition of MOR/alpha2A adrenergic receptor heterodimer expressed in HEK293 cells assessed as stimulation of ERK1/2 phosphorylationMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataEC50: 3nMAssay Description:Binding affinity to rat brain opioid receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Binding affinity to opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Displacement of radiolabeled dihydromorphine from opioid receptor in rat brain homogenatesMore data for this Ligand-Target Pair
TargetDelta-type opioid receptor/Kappa-type opioid receptor/Mu-type opioid receptor/Sigma non-opioid intracellular receptor 1(Rattus norvegicus (rat))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataEC50: 3nMAssay Description:Displacement of [3H]dalamid ([D-Ala2,Met5] enkephalinamide) from opioid receptors of rat brain membraneMore data for this Ligand-Target Pair
Affinity DataEC50: 3.70nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF ...More data for this Ligand-Target Pair
Affinity DataEC50: 4.70nMAssay Description:Agonist activity at human MOR expressed in CHOK1 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by lumi...More data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity at human mu opiod receptor expressed in CHO-K1 cells assessed as increase in forskolin induced cAMP production measured after 30 min...More data for this Ligand-Target Pair
Affinity DataEC50: 8.70nMAssay Description:Agonist activity at human mu opioid receptor expressed in HEK293T cells assessed as Galphai2 activation preincubated for 5 mins with coelenterazine f...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human mu opioid receptor expressed CHO-K1 cells coexpressing Galpha15 assessed as induction of intracellular calcium release by F...More data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 16nMAssay Description:Stimulation of [35S]GTPgammaS binding to human recombinant MORMore data for this Ligand-Target Pair
Affinity DataEC50: 21nMAssay Description:Compound was tested for its ability to stimulate [35S]GTP-gamma-S, binding to membranes from C6 glioma cells stably expressing rat mu opioid receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Agonist activity at mouse MOR assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by cell based TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 34nMpH: 7.4Assay Description:The EC50 and Imax for μ opioid receptors was determined using a [I35S]GTPγS binding assay. This assay measures the functional properties of a compo...More data for this Ligand-Target Pair
Affinity DataEC50: 34nMAssay Description:The EC50 and Imax for μ opioid receptors was determined using a [35S]GTPγS binding assay. This assay measures the functional properties of ...More data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescen...More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Agonist activity at human MOR assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by cell based TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 64nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by ...More data for this Ligand-Target Pair
Affinity DataEC50: 71nMAssay Description:Agonist activity at MOR (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 3...More data for this Ligand-Target Pair
Affinity DataEC50: 72nMAssay Description:Agonist activity at MOR (unknown origin) expressed in HEK293-A cells assessed as inhibition of forskolin-induced cAMP accumulation preincubated for 3...More data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Agonist activity at human mu opioid receptor expressed in HEK293T cells assessed as arrestin-3 recruitment preincubated for 5 mins with coelenterazin...More data for this Ligand-Target Pair
Affinity DataEC50: 79nMAssay Description:Agonist activity at human delta opioid receptor assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 85.5nMAssay Description:Agonist activity at mu opioid receptor in Swiss albino mouse ileum assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Stimulation of mouse MOR expressed in CHO cells after 1.5 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 124nMAssay Description:Agonist activity at rat mu opioid receptor assessed as stimulation of [35]SGTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 124nMAssay Description:Agonist activity at rat mu opioid receptor expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding based liquid scintillation cou...More data for this Ligand-Target Pair
Affinity DataEC50: 124nMAssay Description:Agonist activity at rat MOR expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr by liquid scintillat...More data for this Ligand-Target Pair
Affinity DataEC50: 147nMAssay Description:Agonist activity at human MOR expressed in CHO cell membranes assessed as stimulation of [35S]-GTPgammaS binding incubated for 1 hr by by liquid scin...More data for this Ligand-Target Pair
Affinity DataEC50: 194nMAssay Description:Agonist activity at rat MOR expressed in rat C6 cells assessed as stimulation of [35S]GTPgammaS binding after 1 hr by liquid scintillation counting a...More data for this Ligand-Target Pair
Affinity DataEC50: 194nMAssay Description:Agonist activity at rat Mu-type opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 ...More data for this Ligand-Target Pair
Affinity DataEC50: 204nMAssay Description:Agonist activity at human mu opioid receptor assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: 316nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 316nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 316nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 316nMAssay Description:Stimulation of [35S]GTP-gamma-S binding to human recombinant DORMore data for this Ligand-Target Pair
Affinity DataEC50: 330nMAssay Description:Agonist activity at human kappa opiod receptor expressed in CHO-K1 cells assessed as increase in forskolin induced cAMP production measured after 30 ...More data for this Ligand-Target Pair
Affinity DataEC50: 379nMAssay Description:Agonist activity at human mu opioid receptor expressed in human USOS-beta-arrestin-hMOR-PathHunter cells incubated for 90 mins by beta-arrestin-2 enz...More data for this Ligand-Target Pair
Affinity DataEC50: 380nMAssay Description:Activity at human MOR expressed in CHOK1 cells co-expressing beta-arrestin2 EFC assessed as beta-arrestin2 EFC recruitment measured after 90 mins by ...More data for this Ligand-Target Pair
Affinity DataEC50: 380nMAssay Description:Agonist activity at human mu opiod receptor expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment measured after 90 mins by ...More data for this Ligand-Target Pair
Affinity DataEC50: 395nMAssay Description:Agonist activity at mu opioid receptor in Swiss mouse vas deferens assessed as inhibition of electrically-stimulated twitchMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Mus musculus (Mouse))
University Of Texas At Austin
Curated by ChEMBL
University Of Texas At Austin
Curated by ChEMBL
Affinity DataEC50: 400nMAssay Description:Agonist activity at mouse KOR assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by cell based TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 400nMAssay Description:Agonist activity at human KOR assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by cell based TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: 417nMAssay Description:Agonist activity at human mu opioid receptor expressed in HEK293T cells assessed as Nb33 recruitment preincubated for 5 mins with coelenterazine foll...More data for this Ligand-Target Pair
Affinity DataEC50: 484nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 484nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 484nMAssay Description:Stimulation of [35S]GTP-gamma-S binding to human recombinant KORMore data for this Ligand-Target Pair
Affinity DataEC50: 484nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
