Compile Data Set for Download or QSAR
maximum 50k data
Found 5 of ic50 for monomerid = 25191
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM25191(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Affinity DataIC50:  25nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25191(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Affinity DataKi:  20nM ΔG°:  -43.5kJ/mole IC50:  59nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25191(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Affinity DataIC50:  59nMpH: 7.4 T: 2°CAssay Description:Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Gsk

LigandPNGBDBM25191(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Affinity DataKi:  400nM ΔG°:  -36.2kJ/mole IC50:  2.50E+3nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Gsk

LigandPNGBDBM25191(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Affinity DataKi: >4.00E+3nM ΔG°: >-30.5kJ/mole IC50: >1.60E+4nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed