Compile Data Set for Download or QSAR
Found 2 of ic50 for monomerid = 285032
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM285032(N-[3-(6-ethyl-2-methyl-1-oxoisoquinolin-4-yl) phen...)
Show SMILES CCc1ccc2c(c1)c(cn(C)c2=O)-c1cccc(NS(C)(=O)=O)c1
Show InChI InChI=1S/C19H20N2O3S/c1-4-13-8-9-16-17(10-13)18(12-21(2)19(16)22)14-6-5-7-15(11-14)20-25(3,23)24/h5-12,20H,4H2,1-3H3
Affinity DataIC50: 270nMAssay Description:Inhibition of His-tagged human BRD4-BD1 using H4K5acK8acK12acK16ac as substrate preincubated for 30 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

Curated by ChEMBL
LigandPNGBDBM285032(N-[3-(6-ethyl-2-methyl-1-oxoisoquinolin-4-yl) phen...)
Show SMILES CCc1ccc2c(c1)c(cn(C)c2=O)-c1cccc(NS(C)(=O)=O)c1
Show InChI InChI=1S/C19H20N2O3S/c1-4-13-8-9-16-17(10-13)18(12-21(2)19(16)22)14-6-5-7-15(11-14)20-25(3,23)24/h5-12,20H,4H2,1-3H3
Affinity DataIC50: 500nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid