Compile Data Set for Download or QSAR
Report error Found 11 of ic50 for monomerid = 361577
TargetApoptosis regulator Bcl-2(Human)
BeiGene(Beiing) Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 361577BDBM361577((S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of Bcl-2 (unknown origin) using (Ac-GQVGRQLAIIGDK (FITC) INR-amide) as substrate preincubated for 30 mins followed by substrate addition a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
BeiGene(Beiing) Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 361577BDBM361577((S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 2nMAssay Description:Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respectively, were used as the fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
BeiGene(Beiing) Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 361577BDBM361577((S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 2nMAssay Description:Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respectively, were used as the fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetBcl-2-like protein 11 [72-87](Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 361577BDBM361577((S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 2nMAssay Description:Bcl-2 and Bcl-xL Inhibition: Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2021
Entry Details
US Patent

TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 361577BDBM361577((S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 5.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetBcl-2-like protein 11 [81-106](Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 361577BDBM361577((S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 5.90nMAssay Description:Bcl-2 and Bcl-xL Inhibition: Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2021
Entry Details
US Patent

TargetBcl-2-like protein 1(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 361577BDBM361577((S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 5.90nMAssay Description:Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respectively, were used as the fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
BeiGene(Beiing) Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 361577BDBM361577((S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 57nMAssay Description:Inhibition of Bcl-2 G101V mutant (unknown origin) using (Ac-GQVGRQLAIIGDK (FITC) INR-amide) as substrate preincubated for 30 mins followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 361577BDBM361577((S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 5.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
US Patent

TargetBH3-interacting domain death agonist [79-99](Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 361577BDBM361577((S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 5.00E+3nMAssay Description:Bcl-2 and Bcl-xL Inhibition: Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2021
Entry Details
US Patent

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
University of Michigan

US Patent
LigandChemical structure of BindingDB Monomer ID 361577BDBM361577((S)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitr...)
Affinity DataIC50: 5.00E+3nMAssay Description:Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respectively, were used as the fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
US Patent