Compile Data Set for Download or QSAR
Report error Found 18 of ic50 for monomerid = 50001285
TargetCysteinyl leukotriene receptor 1(Guinea pig)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 0.800nMAssay Description:In vitro inhibition of [3H]LTD4 binding to guinea pig lung membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2012
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Guinea pig)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 3.90nMAssay Description:Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetCysteinyl leukotriene receptor 1(Guinea pig)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 3.90nMAssay Description:Inhibitory concentration against [3H]Leukotriene D4 binding to guinea-pig lung membranes was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2010
Entry Details Article

TargetMultidrug resistance-associated protein 1(Human)
University Hospital Groningen

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 400nMAssay Description:TP_TRANSPORTER: inhibition of Daunorubicin uptake (Daunorubicin: 0.6 uM) in membrane vesicles from GLC4/ADR cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University Hospital Groningen

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of ABCC1 (unknown origin) overexpressing human KBV cells mediated efflux assessed as cisplatin IC50 using cisplatin as substrate at 25 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetATP-binding cassette sub-family C member 2(Rat)
The University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 2.62E+3nMAssay Description:TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University Hospital Groningen

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of recombinant MRP1 expressed in human HeLa T5 cells assessed as ATP-dependent transport of [3H]para-aminohippurateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2019
Entry Details Article
PubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 3.53E+3nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Deutsches Krebsforschungszentrum

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 4.00E+3nMAssay Description:TP_TRANSPORTER: inhibition of PAH uptake (PAH: 0.1uM) in membrane vesicles from MRP2-expressing HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University Hospital Groningen

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 5.22E+3nMAssay Description:Inhibition of human ABCC1 transfected in HEK293 cells assessed as potentiation of etoposide-induced cytotoxicity by measuring etoposide IC50 at 25000...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details Article
PubMed
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 1.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of 9-(2-phosphonomethoxyethyl)adenine(PMEA) efflux (PMEA: 1 uM) in MRP4-expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetMultidrug resistance-associated protein 1(Human)
University Hospital Groningen

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 1.19E+4nMAssay Description:Reversal of human ABCC1-mediated multidrug resistance in HEK293/MRP1 cells assessed as effect on etoposide-induced cytotoxicity by measuring etoposid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 5(Human)
The Netherlands Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 4.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of 9-(2-phosphonomethoxyethyl)adenine(PMEA) efflux (PMEA: 1 uM) in MRP5-expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Federal University of Parana

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human ABCG2 expressed in human SAOS-2 cells mediated mitoxantrone efflux using mitoxantrone as substrate by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetATP-binding cassette sub-family C member 2(Human)
Deutsches Krebsforschungszentrum

Curated by ChEMBL
LigandPNGBDBM50001285(3-(((3-(2-(7-chloroquinoline-2-yl)ethenyl)phenyl)(...)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed