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Report error Found 9 of ic50 for monomerid = 50197883
TargetTransthyretin(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  410nMAssay Description:Binding affinity to human plasma TTR tetramer assessed as displacement of diclofenac-coupled FITC by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  1.55E+3nMAssay Description:Inhibition of wild type TTR (unknown origin) assessed as inhibition of acid-mediated amyloidogenesis by measuring fibril formation preincubated with ...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  2.60E+3nMAssay Description:Stabilization of TTR V3OM mutant (unknown origin) assessed as acid-mediated protein aggregation inhibition ratio incubated for 1 week by absorbance m...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  3.09E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  3.10E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  3.10E+3nMAssay Description:In vitro evaluation of inhibitory activity against WT-TTR amyloid fibril formation of AT09 and reference compounds. Reference compounds (thyroxine, t...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of urea-induced Transthyretin denaturation in human plasma preincubated for 1 hr followed by urea addition by Western blot analysisMore data for this Ligand-Target Pair
TargetRetinol-binding protein 4(Homo sapiens (Human))
Albany College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50: >3.00E+4nMAssay Description:Displacement of [3H]-all trans retinol from human urine biotinylated RBP4 incubated for 16 hrs measured by Scintillation Proximity AssayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed