Compile Data Set for Download or QSAR
Report error Found 3 of ic50 for monomerid = 50297888
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50297888(2-(4-(3-(biphenyl-4-yloxy)propoxy)phenylthio)hexan...)
Affinity DataIC50: 900nMAssay Description:Inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated 15 mins by RP-HPLC analysis in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50297888(2-(4-(3-(biphenyl-4-yloxy)propoxy)phenylthio)hexan...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM50297888(2-(4-(3-(biphenyl-4-yloxy)propoxy)phenylthio)hexan...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli BL21 assessed as enzyme product formation using arachidonic acid as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed