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Report error Found 6 of ic50 for monomerid = 50458159
TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human gamma-secretase by cell based assayMore data for this Ligand-Target Pair
TargetGamma-secretase-activating protein(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50:  6.20nMAssay Description:Inhibitory activity against FAAH in Wistar rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of human gamma-secretaseMore data for this Ligand-Target Pair
TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of gamma secretase isolated from human HeLa cell derived P2 membrane assessed as reduction in amyloid beta (1 to 40 residues) using recomb...More data for this Ligand-Target Pair
TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50:  19nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as reduction in notch signaling by fetal thymus organ culture assayMore data for this Ligand-Target Pair