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TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 3nMAssay Description:Inhibition of DYRK1A (unknown origin) at 1 uM by kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 3nMAssay Description:Inhibition of DYRK1A (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 5nMAssay Description:Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 5nMAssay Description:Inhibition of DYRK1B (unknown origin) at 1 uM by kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human DYRK1A expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 37nMAssay Description:Inhibition of RSK4 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-2(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 61nMAssay Description:Inhibition of RSK3 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 80nMAssay Description:Inhibition of RSK2 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 82nMAssay Description:Inhibition of RSK1 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 90nMAssay Description:Inhibition of FAK (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMisshapen-like kinase 1(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 115nMAssay Description:Inhibition of MINK1 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 132nMAssay Description:Inhibition of MEK4 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 154nMAssay Description:Inhibition of recombinant human DYRK1A expressed in Escherichia coli using DYRKtide peptide as substrate incubated for 110 mins in presence of ATP by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 182nMAssay Description:Inhibition of RSK2 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 210nMAssay Description:Inhibition of FAK (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 367nMAssay Description:Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells using DYRKtide peptide as substrate incubated for 110 mins in presence of ATP by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 690nMAssay Description:Inhibition of SGK (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant human DYRK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of JNK2 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of JNK1 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 19(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of YSK4 (unknown origin) at 1 uM by kinome scan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 3.01E+3nMAssay Description:Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant human GSK-3beta expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity protein kinase CLK4(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human CLK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetCasein kinase I isoform epsilon(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human DYRK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 10(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JNK3 (unknown origin) in human CAL-27 cells measured after 6 hrs by select screen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK3(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 4(Human)
Perha Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50585046(CHEMBL5086263)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human DYRK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed