Compile Data Set for Download or QSAR
Report error Found 4 of ki for monomerid = 22588
TargetBifunctional purine biosynthesis protein ATIC(Human)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 22588BDBM22588({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2,2,4-trioxo-1H,3...)
Affinity DataKi:  150nM ΔG°:  -38.6kJ/molepH: 7.4 T: 2°CAssay Description:The human ATIC enzyme was used for the inhibition assay using the spectrophotometric method monitoring the appearance of IMP by measuring absorbance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 22588BDBM22588({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2,2,4-trioxo-1H,3...)
Affinity DataKi:  4.80E+3nM ΔG°:  -30.5kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed
TargetPhosphoribosylglycinamide formyltransferase(Escherichia coli (strain K12))
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 22588BDBM22588({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2,2,4-trioxo-1H,3...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.9kJ/molepH: 7.5 T: 2°CAssay Description:Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed
TargetBifunctional purine biosynthesis protein ATIC(Human)
The Scripps Research Institute

LigandChemical structure of BindingDB Monomer ID 22588BDBM22588({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2,2,4-trioxo-1H,3...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.6kJ/molepH: 7.5 T: 2°CAssay Description:Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2008
Entry Details Article
PubMed