Compile Data Set for Download or QSAR
Report error Found 14 of ki for monomerid = 50143320
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.00840nMAssay Description:Binding affinity for alpha4 beta-2 nAChR using [3H]epibatidine in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2014
Entry Details Article
PubMed
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.0180nM ΔG°:  -61.3kJ/molepH: 7.4 T: 2°CAssay Description:Adult male rat cerebral cortices (Pelfreeze Biological, Rogers, Ark.) were homogenized in 39 volumes of ice-cold 50 mM Tris buffer (pH 7.4 at 4° C.) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2017
Entry Details
Go to US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.0180nMAssay Description:Inhibition of [3H]nicotine binding to alpha4-beta2 nACh receptor from rat membranes from ref 16More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.0260nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex after 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.0260nMAssay Description:Inhibition of [3H]epibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.0260nMAssay Description:Displacement of [3H]epibatidine from alpha-4-beta-2 nAChRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.0450nMAssay Description:Binding affinity to alpha4beta2 nAChR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2016
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.0450nMAssay Description:Non-specific binding in presence of 300 uM nicotine at nicotinic acetylcholine receptor alpha4-beta2 in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.0450nMAssay Description:Inhibition of [3H]nicotine binding to alpha4-beta2 nACh receptor from rat membranes from ref 14More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H]-cytisine from Alpha4-beta2 Nicotinic acetylcholine receptor of rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.0550nMAssay Description:Inhibition of [3H]nicotine binding to alpha4-beta2 nACh receptor from rat membranes from ref 15More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.160nMAssay Description:in vitro binding affinity by inhibiting [3H]cytisine binding in rat brain tissue at Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Rat)
Swiss Federal Institute of Technology Zurich

Curated by ChEMBL
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]epibatidine from Alpha3 Beta4 Nicotinic acetylcholine receptor of rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Leicester

Curated by ChEMBL
LigandPNGBDBM50143320(2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hept...)
Affinity DataKi:  4.90nMAssay Description:Displacement of [125I-alpha]-Bungarotoxin from alpha-7 nAChR in rat hippocampal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed