Found 432 Enz. Inhib. hit(s) with Target = 'Acetylcholinesterase' and Ligand = 'BDBM8961' 
Affinity DataKi: 6.90nM ΔG°: -46.1kJ/molepH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 7.60nMAssay Description:Inhibition of AChE (unknown origin) using acetylcholine iodate as substrate preincubated for 10 mins followed by substrate addition by Lineweaver-Bur...More data for this Ligand-Target Pair
Affinity DataKi: 7.64nM IC50: 7.53nMpH: 8.0Assay Description:AChI and 5,5'-dithio-bis(2-nitro-benzoic)acid (DTNB) were used as substrate for this enzymatic reaction. To this end, 100 µL of Tris/HCl buffer (...More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Tested for in vitro inhibition of acetylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataKi: 18nM ΔG°: -44.2kJ/molepH: 7.0 T: 2°CAssay Description:Assays were conducted at 25 C in 20 mM sodium phosphate buffer (pH 7.0) and 0.01% bovine serum albumin unless otherwise noted. AChE concentrations we...More data for this Ligand-Target Pair
Affinity DataKi: 20.2nMAssay Description:Inhibition of Electrophorus electricus AChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataKi: 23nMAssay Description:Inhibition of electric eel AChE assessed as dissociation constant for enzyme-inhibitor complex using acetylthiocholine iodide as substrate measured f...More data for this Ligand-Target Pair
Affinity DataKi: 23nMAssay Description:Competitive inhibition of electric eel AChE assessed as enzyme-inhibitor complex using p-nitrophenyl acetate as substrate by Lineweaver-Burk plot ana...More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Inhibitory activity AChE from Electrophorus electricus using ATCh substrate and DTNB by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 5 ...More data for this Ligand-Target Pair
Affinity DataKi: 32nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 36nMAssay Description:Inhibition of human AChE assessed as acetylthiocholine hydrolysisMore data for this Ligand-Target Pair
Affinity DataKi: 36nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
Affinity DataKi: 36nMAssay Description:Inhibition of human recombinant AChEMore data for this Ligand-Target Pair
Affinity DataKi: 40nM ΔG°: -42.2kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Inhibition of fetal Bovine serum AChEMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
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Affinity DataKi: 40nMAssay Description:Inhibition of Torpedo californica AChEMore data for this Ligand-Target Pair
Affinity DataKi: 40nM ΔG°: -42.2kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
Affinity DataKi: 101nMAssay Description:Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor-substrate complex by Lineweaver-Burk plotMore data for this Ligand-Target Pair
Affinity DataKi: 101nMAssay Description:Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor-substrate complex using acetylthiocholine substrate prein...More data for this Ligand-Target Pair
Affinity DataKi: 110nMAssay Description:Binding affinity to AChE (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 137nM ΔG°: -39.2kJ/molepH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by E llman. Inhibition of enzyme activity was measured over a substrate c...More data for this Ligand-Target Pair
Affinity DataKi: 151nM IC50: 250nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
Affinity DataKi: 151nMAssay Description:Inhibitory activity of compound against acetylcholinesterase from human erythrocytesMore data for this Ligand-Target Pair
Affinity DataKi: 151nMAssay Description:Competitive inhibition constant for AcetylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataKi: 225nMAssay Description:Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor complex using acetylthiocholine substrate preincubated fo...More data for this Ligand-Target Pair
Affinity DataKi: 225nMAssay Description:Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor complex by Lineweaver-Burk plotMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
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Curated by ChEMBL
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Curated by ChEMBL
Affinity DataKi: 230nM ΔG°: -38.5kJ/moleT: 2°CAssay Description:AChE and BChE inhibitory activities were measured in vitro by a modified spectrophotometric method. all the inhibition studies were performed using ...More data for this Ligand-Target Pair
Affinity DataKi: 340nMAssay Description:Non-competitive inhibition of Electrophorus electricus AChE using acetylcholine as substrate by Lineweaver-Burk plot methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.16nMAssay Description:Inhibition of AChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.46nMAssay Description:Enzyme activity using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).More data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Inhibition of AChE (unknown origin) using acetylcholine iodate as substrate preincubated for 10 mins followed by substrate addition by Ellman's metho...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Tetronarce californica (Pacific electric ray) (Tor...)
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Curated by ChEMBL
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Curated by ChEMBL
Affinity DataIC50: 8.20nMpH: 7.8 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.30nMAssay Description:Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Affinity DataIC50: 15.6nMAssay Description:Inhibition of electric eel AChE by colorimetric Ellman assayMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:In vitro inhibitory activity against acetylcholinesterase (AChE) in Electrophorus electricusMore data for this Ligand-Target Pair
Affinity DataIC50: 17.4nMAssay Description:Inhibition of electric eel AChE preincubated for 5 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Tested for binding affinity against human NK-1 receptor transfected on CHO cells using [125I]-Tyr] SP as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of electric eel AChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human erythrocyte AChE using ATC iodide as substrate preincubated for 4.5 mins followed by substrate addition measured after 2.5 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and me...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of Electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 m...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition and measured after 5 ...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 m...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of electric eel AChEMore data for this Ligand-Target Pair
