Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with Target = 'Adenosine receptor A1' and Ligand = 'BDBM50053929'
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053929BDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKd:  16nMAssay Description:Binding affinity to Nluc-A1R (unknown origin) expressed in HEK293 cells by nanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053929BDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataIC50: 48nMAssay Description:Antagonist activity at wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as inhibition of NECA reduced forskolin stimulated cAMP accu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053929BDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataEC50:  48nMAssay Description:Antagonist activity at human wild type A1R expressed in CHO-K1 cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053929BDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKi:  51nMAssay Description:Displacement of CA200645 from NLuc human A1 receptor expressed in HEK293 cells assessed as inhibition constant by NanoBRET binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053929BDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKi:  51nMAssay Description:Binding affinity to wild type A1R (unknown origin) expressed in CHO-K1 cells assessed as equilibrium binding affinity constant by nanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053929BDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKi:  52.7nMAssay Description:Binding affinity was determined in radioligand binding assay at rat brain adenosine A1 receptor vs [3H]R-PIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053929BDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKi:  53nMAssay Description:Displacement of [3H]CCPA from rat adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053929BDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKi:  53nMAssay Description:Displacement of [3H]DPCPX from Adenosine A1 receptor of rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
National and Kapodistrian University of Athens

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053929BDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKi:  231nMAssay Description:Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053929BDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKi:  305nMAssay Description:Displacement of [3H]-(R)-PIA from Adenosine A1 receptor of rat cerebral cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053929BDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKi:  305nMAssay Description:Inhibition of [3H]DPCPX binding to rat Adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50053929BDBM50053929(N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]q...)
Affinity DataKi:  305nMAssay Description:Displacement of specific [3H](R)-PIA binding at adenosine A1 receptor from rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed