Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with Target = 'Adenosine receptor A1' and Ligand = 'BDBM50597191'
TargetAdenosine receptor A1(Human)
University of Cambridge

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597191BDBM50597191(CHEMBL5195631)
Affinity DataKi:  11nMAssay Description:Displacement of CA200645 from NLuc human A1 receptor expressed in HEK293 cells assessed as inhibition constant by NanoBRET binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Cambridge

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597191BDBM50597191(CHEMBL5195631)
Affinity DataKi:  21nMAssay Description:Binding affinity to wild type human A1R in presence of CA200645 by saturation NanoBRET binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Cambridge

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597191BDBM50597191(CHEMBL5195631)
Affinity DataKi:  24nMAssay Description:Binding affinity to human A1R H251 6.52A mutant in presence of CA200645 by saturation NanoBRET binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Cambridge

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597191BDBM50597191(CHEMBL5195631)
Affinity DataKi:  27nMAssay Description:Binding affinity to human A1R L250 6.51A mutant in presence of CA200645 by saturation NanoBRET binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Cambridge

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597191BDBM50597191(CHEMBL5195631)
Affinity DataKi:  46nMAssay Description:Binding affinity to human A1R E172 5.30A mutant in presence of CA200645 by saturation NanoBRET binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Cambridge

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597191BDBM50597191(CHEMBL5195631)
Affinity DataKd:  55nMAssay Description:Binding affinity to NLuc human A1 receptor expressed in HEK293 cells assessed as dissociation constant by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetAdenosine receptor A1(Human)
University of Cambridge

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597191BDBM50597191(CHEMBL5195631)
Affinity DataEC50:  71nMAssay Description:Antagonist activity at human wild type A1R expressed in CHO-K1 cells assessed as inhibition of forskolin/ NECA-stimulated cAMP accumulation by measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed