Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with Target = 'Aurora kinase B' and Ligand = 'BDBM50241089'
TargetAurora kinase B(Human)
University of California Davis Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241089BDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataKi:  0.359nMAssay Description:Inhibition of human aurora BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
University of California Davis Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241089BDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataKi:  0.360nMAssay Description:Binding affinity to Aurora B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
University of California Davis Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241089BDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataKi:  0.370nMAssay Description:Inhibition of aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of California Davis Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241089BDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2017
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of California Davis Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241089BDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of Aurora B kinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAurora kinase B(Human)
University of California Davis Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241089BDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 1nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of California Davis Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241089BDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Aurora B in human SW620 cells assessed as inhibition of histone H3 phosphorylation at Ser10 residue incubated for 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
University of California Davis Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241089BDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 15.5nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2012
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University of California Davis Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241089BDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 111nMAssay Description:Inhibition of Aurora B in Melphalan Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
University of California Davis Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241089BDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 693nMAssay Description:Inhibition of Aurora B in human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
University of California Davis Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241089BDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora B in human U-266 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proli...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
University of California Davis Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241089BDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora B in human ANBL-6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
University of California Davis Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241089BDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora B in bortezomib Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
University of California Davis Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241089BDBM50241089(CHEMBL415049 | AZD1152, 33 | 2-(ethyl(3-(4-(5-(2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora B in human bortezomib-resistant ANBL6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous on...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed