Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with Target = 'Beta-hexosaminidase subunit alpha' and Ligand = 'BDBM18788'
TargetBeta-hexosaminidase subunit alpha(Human)
Sickkids

Curated by ChEMBL
LigandPNGBDBM18788(CHEMBL22148 | 6-ethyl-5-phenylpyrimidine-2,4-diami...)
Affinity DataIC50: 1.10E+4nMpH: 7.0Assay Description:Inhibition of human placental HexA using MUGS substrate incubated for 1 to 2 hrs at pH 7.0 by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha(Human)
Sickkids

Curated by ChEMBL
LigandPNGBDBM18788(CHEMBL22148 | 6-ethyl-5-phenylpyrimidine-2,4-diami...)
Affinity DataIC50: 2.70E+4nMpH: 4.5Assay Description:Inhibition of HexA alpha G269S mutant in ATSD patient fibroblasts using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha(Human)
Sickkids

Curated by ChEMBL
LigandPNGBDBM18788(CHEMBL22148 | 6-ethyl-5-phenylpyrimidine-2,4-diami...)
Affinity DataIC50: 2.70E+4nMpH: 4.5Assay Description:Inhibition of HexA in normal human fibroblasts using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha(Human)
Sickkids

Curated by ChEMBL
LigandPNGBDBM18788(CHEMBL22148 | 6-ethyl-5-phenylpyrimidine-2,4-diami...)
Affinity DataIC50: 3.00E+4nMpH: 4.5Assay Description:Inhibition of human placental HexA using MUGS substrate incubated for 1 to 2 hrs at pH 4.5 by spectrofluorometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed
TargetBeta-hexosaminidase subunit alpha(Human)
Sickkids

Curated by ChEMBL
LigandPNGBDBM18788(CHEMBL22148 | 6-ethyl-5-phenylpyrimidine-2,4-diami...)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of human placental HexA using pNPGlcNAc substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2016
Entry Details Article
PubMed