Found 41 Enz. Inhib. hit(s) with Target = 'Carboxylic ester hydrolase' and Ligand = 'BDBM8960' 
Affinity DataKi: 640nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of BChE in rat serum using butyrylthiocholine iodide substrate incubated for 15 mins by UV spectroscopy based Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.87E+3nMpH: 8.0 T: 2°CAssay Description:Suitable agents like donepezil hydrochloride and tacrine hydrochloride hydrate were used as standards for this study. Buffer solution (50 mM Tris-HCl...More data for this Ligand-Target Pair
Affinity DataIC50: 2.77E+3nMAssay Description:Inhibition of BChE in rat serum after 15 mins by modified Ellman methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Compound was evaluated for the in vitro inhibition of the Butyrylcholinesterase from horse serumMore data for this Ligand-Target Pair
Affinity DataIC50: 3.26E+3nMAssay Description:Inhibition of BuchE in rat serum by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.37E+3nMAssay Description:Inhibition of equine BChE preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of equine BChE incubated with compounf for 5 mins before addition of substrate S-butyrylthiocholine iodide by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.17E+3nMAssay Description:Inhibition of (BChE) Butyrylcholinesterase of horse serumMore data for this Ligand-Target Pair
Affinity DataIC50: 4.42E+3nMAssay Description:Inhibition of rat serum BChE using butyrylthiocholine chloride as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.67E+3nMAssay Description:Inhibition of BChE in rat serum after 15 mins by modified Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.94E+3nMpH: 8.0 T: 2°CAssay Description:Reactions were performed in a mediumcontaining substrate (0.05-0.4 mM) combined with 0.125 mM DTNB in 100 mM 3-(N-morpholino)propanesulfonic acid buf...More data for this Ligand-Target Pair
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of rat cortex homogenate BuChE by spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of rat plasma butyrylcholine esterase in presence of butyrylcholine substrate by chemiluminescent assayChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 5.40E+3nMpH: 8.0 T: 2°CAssay Description:AChE and BChE inhibitory assay was carried out by following Ellman's methodology [Ellman et al., Biochem. Pharmacol., 7:88-95] using AChE (Electric e...More data for this Ligand-Target Pair
Affinity DataIC50: 5.40E+3nMpH: 8.0Assay Description:The synthesized compounds (each separately) were dissolved in a mixture of DMSO (1 ml) and methanol (9 ml) and then diluted in KH2PO4/K2HPO4 buffer (...More data for this Ligand-Target Pair
Affinity DataIC50: 6.41E+3nMAssay Description:Newly synthesized coumarin thioureas were tested against electric eel AChE and horse serum BChE. The cholinesterase inhibitory activity was measured ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.41E+3nMpH: 8.0 T: 2°CAssay Description:A 96-microliter well plate was used for screening purpose. Each pyridopyrazine derivative was first dissolved in dimethyl sulfoxide to prepare the st...More data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+3nMpH: 8.0 T: 2°CAssay Description:This spectrophotometric assay is based on the reaction of
5,5-dithio-bis(2-nitrobenzoic)acid (DTNB) with thiocholine to yield a
colored product. Sh...More data for this Ligand-Target Pair
Affinity DataIC50: 7.14E+3nMAssay Description:Inhibitory concentration was determined in in vitro for Butyrylcholinesterase in rat plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 7.14E+3nMAssay Description:Inhibition of rat serum BChEMore data for this Ligand-Target Pair
Affinity DataIC50: 7.14E+3nMAssay Description:ButyrylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 7.18E+3nMAssay Description:Enzyme solutions were prepared in gelatine solution (1%), at a concentration of 2.5 units/mL. AChE or BChE solution (50 μL) and compound solutio...More data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+3nMpH: 8.0Assay Description:The inhibitory activity of the enzyme acetylcholinesterase (AChE) was evaluated by the Ellman method (Biochem. Pharmacol. 1961, 7, 88) using an elect...More data for this Ligand-Target Pair
Affinity DataIC50: 7.52E+3nMpH: 8.0 T: 2°CAssay Description:Seven different concentrations of the synthesized compounds in the range 10^−3-10^−9 M were measured at 412 nm. All the assays were under...More data for this Ligand-Target Pair
Affinity DataIC50: 7.60E+3nMAssay Description:In vitro inhibitory concentration against butyrylcholinesterase was determined using rat serum homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 8.41E+3nMpH: 8.0Assay Description:Inhibitory activities of AChE and BChE were evaluated by using the Ellman's method [34]. Herein compounds 2(a-h) and 5(a-h) were evaluated as inh...More data for this Ligand-Target Pair
Affinity DataIC50: 1.08E+4nMAssay Description:Inhibition of rat serum BuChE using S-butyrylthiocholine iodide as substrate incubated for 8 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:The stock solutions of the target compounds were prepared in a mixture of DMSO (1 ml) and ethanol (9 ml) and diluted with 0.1 MKH2PO4/K2HPO4 buffer (...More data for this Ligand-Target Pair
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of rat serum BChE using butyrylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.07E+4nMAssay Description:Inhibition of rat serum BuChE using butyrylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.07E+4nMAssay Description:Inhibition of rat serum BChE using acetylthiocholine iodide as substrate measured after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.07E+4nMAssay Description:Inhibition of rat serum BuChE using butyrylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.07E+4nMAssay Description:Inhibition of rat serum BuChE by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.14E+4nMAssay Description:Inhibition of rat serum BuChE using butyrylthiocholine iodide as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.14E+4nMAssay Description:Inhibition of rat serum butyrylcholinesterase using butyrylthiocholine iodide as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.14E+4nMAssay Description:Inhibition of rat serum BuChE measured after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.14E+4nMAssay Description:For AChE or BuChE inhibition assays, a reaction mixture (100 mL) containing acetylthiocholine iodide (1 mmol/L, 30 mL) or butyrylthiocholine iodide (...More data for this Ligand-Target Pair
Affinity DataIC50: 3.73E+4nMAssay Description:Inhibition of BuChE in rat serum using butyrylthiocholine as substrate measured after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.46E+4nMAssay Description:Inhibition of BuChE in rat serum using S-butylthiocholine iodide as substrate by Ellman's methodMore data for this Ligand-Target Pair
