BindingDB PrimarySearch

Found 27 Enz. Inhib. hit(s) with Target = 'Casein kinase II subunit alpha' and Ligand = 'BDBM50335638'

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

Ki: 0.380nMAssay Description:Inhibition of CK2alpha (unknown origin) using RRRADDSDDDDD as substrate in presence of [gamma33P]-ATP by autoradiographyMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 0.5nMAssay Description:Displacement of 5-TAMRA-labeled ARC-1530 from CK2alpha (unknown origin) (1 to 335 residues) after 15 to 60 mins by luminescence assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 1nMAssay Description:Inhibition of recombinant human CK2alpha (1 to 336 residues) expressed in Escherichia coli BL21 (DE3) using RRADDSDDDD as substrate incubated for 10 ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 1nMAssay Description:Inhibition of recombinant human CK2alpha in presence of ATP at Km concentration by radiometric filter-binding assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 1nMAssay Description:Inhibition of human recombinant CK2alphaMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 1nMAssay Description:Inhibition of human recombinant CK2alpha at enzyme-substrate complex by radiometric assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 1nMAssay Description:Inhibition of human recombinant CK2alpha by radiometric assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 2nMpH: 7.2Assay Description:Test compounds in aqueous solution were added at a volume of 10 microliters, to a reaction mixture comprising 10 microliters Assay Dilution Buffer (A...More data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 2nMAssay Description:Test compounds in aqueous solution were added at a volume of 10 microliters, to a reaction mixture comprising 10 microliters Assay Dilution Buffer (A...More data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: <3nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged CK2alpha expressed in Sf21 insect cells using CK2tide as substrate treated for 20 ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 6nMAssay Description:Displacement of fluorescent tracer from full-length human C-terminal NanoLuc-tagged CK2alpha expressed in HEK293T permeabilized cells measured after ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 14nMAssay Description:Inhibition of recombinant human CK2alpha using RRRDDDSDDD substrate and [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 14nMAssay Description:Inhibition of recombinant human CK2alpha using RRRDDDSDDD substrate and [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 15nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 15nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 15nMAssay Description:Inhibition of CK2alpha (unknown origin) (2 to 329 residues) expressed in Escherichia coli BL21 (DE3) using RRRADDSDDDD substrate incubated for 40 min...More data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 19nMAssay Description:Inhibition of GST-tagged human CK2alpha (1 to 391 residues) using CK2tide as substrate incubated for 1 hr by off-chip mobility shift assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 20nMAssay Description:Inhibition of CK2alpha (unknown origin) (1 to 335 residues) using 5-TAMRA-RADDSDDDDD as substrate after 30 mins by fluorescence imaging methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 96nMAssay Description:Displacement of fluorescent tracer from full-length human C-terminal NanoLuc-tagged CK2alpha expressed in HEK293T cells measured after 2 hrs by NanoB...More data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 100nMAssay Description:Inhibition of CK2alpha1 (unknown origin) using casein as substrate in presence of [gamma33P]ATPMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 100nMpH: 7.4Assay Description:The human leukemia Jurkat T-cell line was maintained in RPMI 1640 (Cambrex) supplemented with 10% fetal calf serum and 50 ng/ml Geutamycin. Before tr...More data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 2.00E+3nMAssay Description:Inhibition of CK2alpha (unknown origin) assessed as reduction in nucleolin phosphorylation in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: 2.00E+3nMAssay Description:Inhibition of CK2alpha (unknown origin) assessed as reduction in GST-Six1 phosphorylation in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

PDB Reactome pathway
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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

Kd: 0.562nMAssay Description:Inhibition of ARC-1504 binding to CK2alpha (unknown origin) (1 to 335 residues) measured after 15 mins by fluorescence anisotropic methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

Kd: 0.560nMAssay Description:Inhibition of ARC-1504 binding to CK2alpha (unknown origin) (1 to 335 residues) measured after 15 mins by fluorescence anisotropic methodMore data for this Ligand-Target Pair

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3D Structure (crystal)

Filter my 27 hits

Targets 1▿
- Casein kinase II subunit alpha 27
Publications 14▿
- J Med Chem 62: 1817-1836 (2019) 8
- Eur J Med Chem 208: (2020) 3
- Bioorg Med Chem 25: 2277-2284 (2017) 3
- US Patent US9062043 (2015) 2
- J Med Chem 54: 635-54 (2011) 2
- Bioorg Med Chem Lett 28: 1336-1341 (2018) 1
- Eur J Med Chem 195: (2020) 1
- Eur J Med Chem 181: (2019) 1
- Bioorg Med Chem 24: 1136-41 (2016) 1
- Eur J Med Chem 78: 217-24 (2014) 1
- Eur J Med Chem 216: (2021) 1
- Bioorg Med Chem 26: 3016-3020 (2018) 1
- US Patent US8168651 (2012) 1
- Bioorg Med Chem 26: 5062-5068 (2018) 1
Institutions 12▿
- Universit£ 8
- University Of Tartu 4
- Goethe University Frankfurt 3
- Cylene Pharmaceuticals 3
- Senhwa Biosciences 2
- Kyoto University 1
- Astrazeneca 1
- China Pharmaceutical University 1
- Cha University 1
- University Of Cambridge 1
- University Of Trento 1
- Siedlce University Of Natural Sciences And Humanities 1
Affinity: 0.38 to 2.0E+3 nM▿
- Ki 1
- IC50 24
- Kd 2
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1