Compile Data Set for Download or QSAR
Found 2 Enz. Inhib. hit(s) with Target = 'Corticotropin-releasing factor receptor 1' and Ligand = 'BDBM50351386'
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50351386(CHEMBL1819076)
Show SMILES CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1c(C)cc(OC)cc1C
Show InChI InChI=1S/C24H32N4O/c1-7-17(8-2)25-23-19-10-9-11-20(19)26-24-22(16(5)27-28(23)24)21-14(3)12-18(29-6)13-15(21)4/h12-13,17,25H,7-11H2,1-6H3
Affinity DataIC50: 9nMAssay Description:Displacement of [125I]CRF from human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells after 2 hrs by gamma countingMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Minase Research Institute

Curated by ChEMBL
LigandPNGBDBM50351386(CHEMBL1819076)
Show SMILES CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1c(C)cc(OC)cc1C
Show InChI InChI=1S/C24H32N4O/c1-7-17(8-2)25-23-19-10-9-11-20(19)26-24-22(16(5)27-28(23)24)21-14(3)12-18(29-6)13-15(21)4/h12-13,17,25H,7-11H2,1-6H3
Affinity DataEC50:  80nMAssay Description:Antagonist activity at human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP productio...More data for this Ligand-Target Pair