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Found 2 Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 12' and Ligand = 'BDBM50367682'
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50367682(CHEMBL4162128)
Affinity DataIC50:  110nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 12(Homo sapiens)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50367682(CHEMBL4162128)
Affinity DataIC50:  259nMAssay Description:Inhibition of CDK12 in human SK-BR-3 cells assessed as reduction in RNA polymerase 2 Ser2 phosphorylation incubated for 4 hrs byMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed