Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 2/G1/S-specific cyclin-E1' and Ligand = 'BDBM8037'
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of Tours

Curated by ChEMBL
LigandPNGBDBM8037(4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine...)
Affinity DataIC50: 6.46E+3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of Tours

Curated by ChEMBL
LigandPNGBDBM8037(4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine...)
Affinity DataKi:  6.50E+3nM ΔG°:  -30.1kJ/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
University of Tours

Curated by ChEMBL
LigandPNGBDBM8037(4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine...)
Affinity DataKi:  6.50E+3nMAssay Description:Inhibition of recombinant human His6-tagged CDK2/cyclin E expressed in baculovirus infected sf9 cells using histone H1 susbtrate in presence of [gamm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed