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Report error Found 81 Enz. Inhib. hit(s) with Target = 'D(2) dopamine receptor' and Ligand = 'BDBM50001885'
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 3.60nMAssay Description:The ability of Compound 102 to bind dopamine D2 receptors was measured in a cell-based assay. Dopamine D2 receptor cells were seeded in a half a blac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 3.60nMAssay Description:The ability of Compound 102 to bind dopamine D2 receptors was measured in a cell-based assay. Dopamine D2 receptor cells were seeded in a half a blac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 4nMAssay Description:Compound was tested for the inhibition of [3H]spiperone binding to dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 7.10nMAssay Description:Antagonist activity at dopamine D2 receptor (unknown origin) after 60 mins by Ultra lance cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/15/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 10.4nMAssay Description:The ability of Compound 102 to bind the dopamine D2 receptor in a membrane preparation was examined. Medium was removed from dopamine D2 receptor cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 10.4nMAssay Description:The ability of Compound 102 to bind the dopamine D2 receptor in a membrane preparation was examined. Medium was removed from dopamine D2 receptor cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 13.3nMAssay Description:The D2 receptor antagonism activity test (The antagonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Mouse)
Glaxo Wellcome

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 23nMAssay Description:Inhibition of mouse Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 27nMAssay Description:Inhibition of [3H]methylspiperone binding to rat striatal membrane Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 30nMAssay Description:Compound was measured for affinity at dopamine receptor D2 labeled with [3H]spiroperidol radioligand in striatum tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 37nMAssay Description:Binding affinity towards Dopamine receptor D2 was determined in rat striatum using [3H]- spiperone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 37nMAssay Description:In vitro affinity towards D2 receptor using [3H]spiroperidol as radioligand in striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 38nMAssay Description:Affinity for dopamine receptor D2 binding sites by its ability to displace [3H]spiperone from rat striatum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataIC50: 1.00E+5nMAssay Description:The D2 receptor agonism activity test (The agonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293 cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  0.300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  0.440nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  0.440nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  0.440nMAssay Description:Binding affinity towards human D2 dopamine receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  0.600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]-raclopride from human D2LR expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Pig)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  0.830nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  1.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2012
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  1.40nMAssay Description:Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D2L in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  1.58nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  1.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  1.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  1.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  1.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  1.80nMAssay Description:Ability to displace [3H]spiperone from D2 dopamine receptor isolated from the striata of male Wistar ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  2.10nMAssay Description:Affinity for Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to human cloned dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  2.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]methylspiperone from human low affinity Dopamine D2S receptor by competition binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  2.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
In Depth
Date in BDB:
2/23/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity for dopamine receptor D2 determined using [3H]spiperoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  3.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  3.10nMAssay Description:Compound was evaluated for its binding affinity with Dopamine receptor D2 using membranes prepared from rat striatumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity towards human Dopamine receptor D2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  3.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  3.30nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Lb Pharmaceuticals

US Patent
LigandPNGBDBM50001885(3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin...)
Affinity DataKi:  3.60nMAssay Description:Antagonist activity at D2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
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