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Found 2 Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 2' and Ligand = 'BDBM360543'
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM360543(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)sp...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 cell membranes assessed as triolein formation by LC/MS/MS analysis using oleoyl-CoA as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM360543(N-((5-(3-methoxyphenyl)isoquinolin- 8-yl)methyl)sp...)
Affinity DataIC50:  243nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent